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Fungicide behaviour<br />

Bringing new crop protection products to market<br />

is no mean feat. However, there’s a constant<br />

demand to bring the next new innovation to<br />

market, which supports growers and their<br />

continuing efforts to control economically<br />

damaging diseases. Syngenta is committed<br />

to driving innovation and delivering<br />

class-leading crop protection<br />

solutions that respond to<br />

market needs.<br />

Why molecular<br />

movements<br />

matter<br />

Discovering how a fungicide behaves<br />

throws light on its efficacy in the field.<br />

CPM digs into the performance of Solatenol<br />

by following its journey from the moment it<br />

lands on a leaf.<br />

By Lucy de la Pasture<br />

These days it’s not very often a<br />

new active ingredient becomes<br />

available. This season growers<br />

have a new fungicide from<br />

Syngenta, Elatus Era, which<br />

contains the SDHI active,<br />

benzovindiflupyr (branded as<br />

Solatenol) in formulation with<br />

the azole, prothioconazole.<br />

Amongst the R&D processes<br />

at Syngenta that underpin the<br />

screening and development of<br />

active molecules, is a science that<br />

studies their behaviour from the<br />

time of application until they’re<br />

broken down in the plant –– a field<br />

known as biokinetics.<br />

Dave Bartlett, principal technical<br />

specialist at Syngenta’s Jealott’s<br />

Hill facility, leads the fungicide<br />

biokinetics team and explains what<br />

their studies have revealed, using<br />

Elatus Era to illustrate the value of<br />

<strong>this</strong> knowledge. ADAS principal<br />

research scientist, Jonathan Blake,<br />

goes on to explain how <strong>this</strong> then<br />

translates to field experience of the<br />

new fungicide.<br />

What is biokinetics?<br />

Fungicide efficacy is a well<br />

understood term in disease control<br />

but a less familiar concept to many<br />

is biokinetics.<br />

14 crop production magazine arable extra march 2017<br />

Part and parcel to any crop<br />

protection product’s efficacy is<br />

the journey the active molecule<br />

makes from the moment it lands<br />

on the leaf, its progress to the<br />

biochemical target site and then<br />

what happens to it thereafter. It’s<br />

an area of research that Syngenta<br />

has focussed on over the past<br />

thirty years and is known as<br />

biokinetics.<br />

Studying a molecule in <strong>this</strong> way<br />

reveals the range of properties a<br />

product possesses –– <strong>this</strong><br />

includes leaf surface stability,<br />

rainfastness, rate of movement<br />

into the leaf and subsequent<br />

distribution that together help<br />

explain the efficacy of a product.<br />

How’s it evaluated?<br />

Biokinetic studies can quantify<br />

analytically how much fungicide<br />

moves in the plant and where and<br />

when <strong>this</strong> happens. At Syngenta,<br />

biological assays run in parallel<br />

with biokinetics, so the same<br />

leaves are used for quantitative<br />

analysis by the biokinetics team as<br />

are assessed for disease<br />

control by the biologists. It’s a<br />

hand-in-hand process that’s led to<br />

an industry-leading understanding<br />

of how a molecule can deliver<br />

disease control in the field.<br />

One of the methods used to<br />

track the journey of products<br />

through the plant is phosphor<br />

imaging, where radioactive<br />

c14-labelled fungicides are used to<br />

produce a computer image. These<br />

images are then related to the<br />

analytical and biological data<br />

which has also been collected.<br />

A further research team allows<br />

even more fine detail to be added<br />

to what’s happening within the<br />

plant when it comes to disease<br />

control. Microscopy is used to<br />

examine how diseases affect<br />

plants on a cellular level and how<br />

the fungicide is actually working<br />

on the pathogen.<br />

How does it relate to<br />

fungicides?<br />

From following every step of its<br />

journey, the team have discovered<br />

Dave Bartlett explains how the<br />

biokinetic profile of Solatenol relates<br />

to its efficacy.

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