Investigation of fruit peel extracts as sources for ... - ThaiScience

Table 3
IC 50 and ED 50 values of the fractionated peel extracts for KB cell line, Caco-2 cell line and PBMC normal cells.
Fractionated extracts KB Caco-2 PBMC
IC50 (lg/mL) ED50 (lg/mL) IC50 (lg/mL) ED50 (lg/mL) IC50 (lg/mL) ED50 (lg/mL)
HCP 7.7 ± 0.5 ND ND >100 >100 ND
ECP ND 13.4 ± 5.6 ND 48.3 ± 2.7 ND >100
BCP ND 33.5 ± 1.3 ND >100 ND 82.3 ± 11.4
MCP >100 ND ND >100 ND >100
HRP ND >100 >100 ND ND >100
ERP >100 ND >100 ND ND >100
BRP ND 15.7 ± 6.9 >100 ND ND >100
MRP ND 9.8 ± 3.4 >100 ND ND >100
HMP 97.4 ± 17.7 ND 13.0 ± 3.8 ND 13.4 ± 1.8 ND
EMP 24.3 ± 0.3 ND 8.1 ± 0.1 ND 5.9 ± 0.2 ND
BMP 8.2 ± 1.6 ND 33.7 ± 2.8 ND 24.2 ± 1.2 ND
MMP ND >100 98.8 ± 2.8 ND 11.3 ± 0.2 ND
Tamoxifen ND ND 4.0 ± 0.4 ND 4.0 ± 0.7 ND
ND = Not detectable.
4. Conclusion
In this study, we have shown that rambutan peel extracts, particularly
the ERP and MRP fractions possess strong radical scavenging
activity and ferric ion reduction capacity. It was shown that
polyphenolic compounds in extracts are most likely responsible
for the observed antioxidant action. Interestingly, HCP showed a
high cytotoxic effect towards KB cells, but possessed no detectable
cytotoxicity towards PBMCs. In future studies, it is our aim to
establish the chemical structures and biological activities of the
compounds present in ERP responsible for the antioxidant activity
and present in HCP responsible for the antiproliferative activity.
Conflict of Interest
The authors declare that there are no conflicts of interest.
Acknowledgements
The authors are grateful for the financial support of the Royal
Golden Jubilee (RGJ) Grant by the Thailand Research Fund (TRF).
We also thank Professor Dr. Wim E. Hennink of the Faculty of Science,
Utrecht University, the Netherlands, for valuable discussions.
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