next-generation-sequencing-ngs-market-5Bplatforms-illumina-hiseq-miseq-life-technologies-ion-proton2Fpgm-454-roche-bioinformatics-rna-seq-chip-seq-pyrosequencing-sbs-smrt-diagnostics-personalized-medi-24marketrepo

Report Title:
Next Generation Sequencing (NGS) Market
[Platforms (Illumina HiSeq, MiSeq, Life Technologies
Ion Proton/PGM, 454 Roche), Bioinformatics (RNA-
Seq, ChIP-Seq), (Pyrosequencing, SBS, SMRT),
(Diagnostics, Personalized Medicine)] – Global
Forecast to 2017
Published On: December 2016
Pages: 350
Category: Life Sciences
Report Overview:
The next generation sequencing market is rapidly evolving with a large number of
developments taking place to increase accuracy and speed, and reduce costs of sequencing. It
is the fastest-growing and most lucrative segment in the genomics space with an estimated
growth of 16.3%. The global NGS market was valued at $1.3 billion in 2012 and is poised to
reach $2.7 billion by 2017. By supporting genomics research, various government bodies like
NHGRI (National Human Genome Research Institute, U.S.) and Biotechnology and Biological
Sciences Research Council (BBSRC, U.K.) are increasing the adoption of high-throughput
sequencing platforms.
The growth of the overall NGS market is driven by continuous innovations and developments in
the market aimed at higher throughput, increased accuracy, and affordable costs. However,
factors such as high reliability on grants and funding from the government, and decrease in
capital expenditure from academic institutions are hindering the growth of the market. In
addition, the interpretation of big data generated by sequencers and the subsequent storage
and management of the analyzed data is still a challenge. Owing to the complexity of NGS
technologies and data, standardization of the overall NGS workflow presents an unmet need.
The opportunities for the growth of this market include developments in the pre-sequencing,
cloud computing, and NGS bioinformatics solutions.
The NGS platforms market was dominated by Illumina in 2012, which accounted for the largest
market share of 56%. Other companies with commercial platforms include Life Technologies
(U.S.), 454 Roche (U.S.), and Pacific Biosciences (U.S.). The recently introduced Bench-top and
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NGS platforms will drive the market. Based on steps in the NGS workflow, the overall NGS
market has three major segments, namely, pre-sequencing, NGS platforms and services, and
NGS data analysis, storage and management.
The raw sequencing data generated by today’s sequencers does not reflect on any meaningful
information in itself. Also, open source tools for analyzing NGS data require adequate
bioinformatics training. These factors open up huge opportunities for commercial NGS
bioinformatics software, workbenches, and services, whose market is currently fragmented
and has a relatively smaller size. Whole genome sequencing, targeted re-sequencing, de novo
sequencing, RNA-Seq, ChIP-Seq and methyl-Seq are the major applications that use NGS data
analysis tools and services. Key players like CLC bio (Denmark), Biomatters (New Zealand),
Partek (U.S.), Genomatix (Germany), Knome (U.S.), and DNASTAR (U.S.) dominate this market
space.
Next generation sequencing is set to revolutionize applied markets like diagnostics, drug
discovery, biomarker discovery, personalized medicine, and agriculture and animals research.
Research institutes and government bodies contribute the highest to the end-user market of
NGS; however, the adoption rate in hospitals will increase in the near future due to cost
effectiveness, high throughput, and sensitivity.
The NGS market will witness a whole new generation of sequencing platforms based on
nanapore sequencing technology and fully integrated instruments that could perform all the
NGS workflow steps.
Scope of the Report
This research report categorizes and analyzes the global NGS market on the basis of steps in
the NGS workflow and NGS applications. These markets are further divided into segments and
sub-segments, to provide exhaustive value analysis for the years 2010, 2011, 2012, and
forecast to 2017. Each market is comprehensively analyzed at a granular level by geography
(North America, Europe, Asia, and Rest of the World) to provide in-depth information on the
global scenario.
Global NGS market, by steps in workflow
Pre-sequencing Products and Services
DNA fragmentation and size selection
Library preparation
Target enrichment
Quality control
Sequencing Platforms, Consumables/Reagents and Services
Illumina
HiSeq Series
Genome Analyzer IIx
HiScanSQ
MiSeq
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Life Technologies
SOLiD Series
Ion PGM (Personal Genome Machine)
Ion Proton
454 Lifesciences (Roche)
GS Junior
GS FLX+
Pacific Biosciences
PacBio RS II
Others
Sequencing Services
NGS Data Analysis/Bioinformatics
By product
NGS data analysis software and workbenches
NGS data analysis services
NGS storage management and cloud computing solutions
By application
Whole Genome Sequencing
Targeted Resequencing
De novo Sequencing
RNA-Seq
ChIP-Seq
Methyl-Seq
Others
Global NGS market, by Technology
Sequencing by synthesis (SBS)
Ion semiconductor sequencing
Sequencing by ligation (SBL)
Pyrosequencing
Single molecule, real-time (SMRT) Sequencing
Global NGS market, by Application
Diagnostics
Drug Discovery
Biomarker Discovery
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Personalized Medicine
Agriculture and Animal Research
Others
NGS market, by Geography
North America
Europe
Asia
RoW (Africa, LATAM, Middle-East, Pacific countries)
Table of Contents:
Table Of Contents
1 Introduction (Page No. - 24)
1.1 Key Take-Aways
1.2 Report Description
1.3 Markets Covered
1.4 Stakeholders
1.5 Research Methodology
1.5.1 Market Size
1.5.2 Market Share
1.5.3 Key Data Points From Secondary Sources
1.5.4 Key Data Points From Primary Sources
1.5.5 Assumptions
2 Executive Summary (Page No. - 33)
3 Market Overview (Page No. - 38)
3.1 Introduction
3.2 Evolution
3.3 Market Segmentation
3.4 Market Dynamics
3.4.1 Drivers
3.4.1.1 Cost and Speed to Drive the Growth of NGS Technology
3.4.1.2 Substitution of Microarray Technology by NGS to Boost Market Growth
3.4.1.3 Embracement of NGS Technology by New Consumers to Propel the Market
3.4.1.4 Increase in Practice for New Scientific Applications to Boost the Growth
3.4.1.5 Research Laboratories and Academicians Promoting the Use of NGS
3.4.2 Restraints
3.4.2.1 High Reliability on Grants to Restrict Growth
3.4.2.2 Decrease in Capital Expenditure from Academic Institutes to Hinder the Sale of
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Platforms
3.4.2.3 Accuracy & Standardization, a Concern in Diagnostic Testing
3.4.3 Opportunities
3.4.3.1 Personalized Medicine & Biomarker Discovery Open Avenues for Investments in NGS
Technology
3.4.3.2 Pre-sequencing, a High Growth Opportunity
3.4.3.3 Cloud Computing, a Prospective Service
3.4.4 Challenges
3.4.4.1 Interpretation of Complex Data from NGS Platforms
3.4.4.2 Designing of Sequencers as the Breadth of NGS Applications Increase
3.4.5 Market Trend
3.4.5.1 Shift of Focus Towards Third Generation Sequencing
3.4.6 Burning Issues
3.4.6.1 Data Storage, an Impediment for NGS Sequencing
3.4.6.2 Reduction in Cost to Sequence Human Genomes
3.4.7 Winning Imperative
3.4.7.1 Improved Collaborative Ties Between Industry and Academic & Research Institutes
3.5 Porter’s Five Forces Analysis
3.5.1 Threat From New Entrants
3.5.2 Threat From Substitutes
3.5.3 Bargaining Power Of Buyers
3.5.4 Bargaining Power Of Suppliers
3.5.5 Competitive Rivalry Among Exisiting Firms
3.6 Value Chain
3.7 Technological Development Road-Map
3.7.1 Sanger Sequencing
3.7.2 Massively Parallel Sequencing (Next Generation Sequencing)
3.7.3 Single Molecule Real Time (SMRT) Sequencing
3.7.4 Nanopore Sequencing
3.8 Technological Trends
3.8.1 Nanopore Sequencing Technology
3.8.1.1 Oxford Nanopore Technologies
3.8.1.2 Genia Technologies
3.8.1.3 Electronic Biosciences
3.8.2 Sequencing By Hybridization Technology (GNUBIO)
3.8.3 GENIUS (Gene Electronic Nano-Integrated Ultra-Sensitive) Technology (GENAPSYS)
3.8.4 Lightning Terminator Sequencing Technology (LASERGEN)
3.8.5 Optical Nanopore Sequencing Technology (NOBLEGEN)
3.8.6 Nanowire Biosensor Sequencing Technology (QUANTUMDX)
3.9 End-User Analysis
3.9.1 Introduction
3.9.2 Research Centers, Academic & Government Institutes
3.9.2.1 NGS is a Research Driven Market, Hence the Highest Market Share
3.9.3 Hospitals & Clinics
3.9.3.1 Hospitals and Clinics to Grow at the Fastest Rate
3.9.4 Pharmaceutical & Biotechnology Companies
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3.9.4.1 Targeted Therapy and Biomarker Research to Boost the Pharmaceutical &
Biotechnology NGS Market
3.9.5 Others
3.10 Market Share Analysis
3.10.1 Total Ngs Market
3.10.1.1 Global
3.10.1.2 North America
3.10.1.3 Europe
3.10.1.4 Asia
3.10.2 NGS Platform Market
3.10.2.1 Global
3.10.2.2 North America
3.10.2.3 Europe
3.10.2.4 Asia
3.10.3 NGS Bioinformatics/Data Analysis Market
3.10.3.1 Global
4 Global Ngs Market, By Steps In Workflow (Page No. - 78)
4.1 Introduction
4.2 Pre-Sequencing Products & Services Market
4.2.1 Sample Preparation
4.2.1.1 Dna Fragmentation, End Repair, A-Tailing And Size Selection
4.2.1.2 Library Preparation
4.2.1.3 Target Enrichment
4.2.1.4 Quality Control
4.3 Sequencing Platforms Market
4.3.1 Illumina
4.3.1.1 Hiseq Series
4.3.1.2 Genome Analyzer IIx
4.3.1.2.1 No Technological Advancements Will Result Into Downfall Of GA IIx
4.3.1.3 HiScanSQ
4.3.1.4 MiSeq
4.3.1.4.1 MiSeq will grow at the fastest pace amongst all the platforms
4.3.2 Life Technologies
4.3.2.1 SOLiD Series
4.3.2.1.1 Solid Series Shows Minimal Scope For Growth
4.3.2.2 Ion Torrent Platforms
4.3.2.2.1 Ion PGM
4.3.2.2.1.1 Currently Ion PGM exceeds the unit sales as compared to its competitors
4.3.2.2.2 Ion Proton
4.3.2.2.2.1 Ion Proton will be one of the fast growing platforms
4.3.3 454 ROCHE
4.3.3.1 GS Junior and GS FLX+ will Grow at Slow Pace in the Coming Years
4.3.3.2 GS Junior
4.3.3.3 GS FLX+
4.3.4 Pacific Biosciences
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4.3.4.1 PacBio RS II
4.3.5 Others
4.4 Sequencing Services Market
4.5 NGS Data Analysis, Storage And Management (Bioinformatics) Market
4.5.1 Open Source Applications Contribute 75% To The Overall Ngs Bioinformatics Solutions
4.5.2 NGS Data Analysis, By Product
4.5.2.1 NGS Data Analysis Software and Workbenches
4.5.2.2 NGS Data Analysis Services
4.5.3 NGS Data Analysis, By Application
4.5.3.1 Whole Genome Sequencing
4.5.3.2 Targeted Re-sequencing
4.5.3.3 DE NOVO Sequencing
4.5.3.4 RNA-Seq
4.5.3.5 CHIP-Seq
4.5.3.6 Methyl-Seq
4.5.3.7 Others
4.5.4 NGS Storage, Management & Cloud Computing Solutions
5 NGS Technology Market (Page No. - 129)
5.1 Introduction
5.2 Sequencing By Synthesis (SBS)
5.2.1 SBS To Be The Fastest-Growing Technology
5.3 ION Semiconductor Sequencing
5.3.1 ION Semiconductor Sequencing, A Fast-Growing Market
5.4 Sequencing By Ligation (SBL)
5.4.1 SBL Technology To Witness Negative Growth
5.5 Pyrosequencing
5.5.1 Pyrosequencing To Grow At Slow Rate
5.6 Single-Molecule Real-Time Sequencing (SMRT)
5.6.1 SMRT Technology Has Limited Applications
6 Global NGS Application Market (Page No. - 141)
6.1 Introduction
6.2 Diagnostics
6.2.1 Diagnostic Market Will Grow With Addition Of Wider Applications
6.2.2 Cancer Diagnostics To Drive the Market
6.3 Drug Discovery
6.3.1 Focus On Targeted Therapy To Boost The Ngs Market
6.4 Biomarker Discovery
6.4.1 Biomarker Discovery Application To Grow At A High Rate
6.5 Personalized Medicine
6.5.1 Personalized Medicine Offers Huge Potential Market
6.6 Agriculture & Animal Research
6.6.1 Applications In Crop Research & Animal Biotechnology To Boost The NGS Market
6.7 Other Applications
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7 Geographic Analysis (Page No. -156)
7.1 Introduction
7.2 North America
7.2.1 Funding By Government Agencies To Boost THE U.S. MARKET
7.2.2 Canadian Government Strive To Boost NGS Market
7.3 Europe
7.3.1 Germany Holds The Largest Share Of European NGS Market
7.3.2 U.K. To Contribute Substantially To Europe
7.4 Asia
7.4.1 China & Other Nations Focus On Research In NGS
7.4.2 Regular Funding From Indian Government, An Impetus To The Ngs Market
7.5 Rest Of The World (ROW)
8 Competitive Landscape (Page No. - 186)
8.1 Introduction
8.1.1 New Product Launch & Agreements And Partnerships, Highly Adopted Strategies For
Growth
8.2 Mergers & Acquisitions
8.3 Agreements, Partnerships, Collaborations & Joint Ventures
8.4 New Product Launch
8.5 Expansion
9 Company Profiles (Overview, Financials, Products & Services, Strategy, & Developments)*
(Page No. - 236)
9.1 454 Life Sciences Corporation (A Roche Company)
9.2 Agilent Technologies, Inc.
9.3 BGI (Beijing Genomics Institute)
9.4 Biomatters, Ltd.
9.5 CLC Bio
9.6 Dnastar, Inc.
9.7 EMC Corporation
9.8 GATC biotech AG
9.9 Genomatix Software GMBH
9.10 Illumina, Inc.
9.11 Knome, Inc.
9.12 Life Technologies Corporation
9.13 Macrogen, Inc.
9.14 Ocimum Biosolutions, Ltd.
9.15 Oxford Nanorpore Technologies, Ltd.
9.16 Pacific Biosciences
9.17 Partek Incorporated
9.18 Perkinelmer, Inc.
9.19 Qiagen N.V.
9.20 Strand Life Sciences Pvt. Ltd.
*Details on Financials, Product & Services, Strategy, & Developments might not be captured in
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case of unlisted companies.
List of Tables (87 Tables)
Table 1 Global Overall NGS Market, By Product, 2010 – 2017 ($Million)
Table 2 Comparison Between Next Generation Sequencing & Microarray
Table 3 Global NGS Market, By End-User, 2012 – 2017 ($Million)
Table 4 Global Overall NGS Market, By Product, 2010 – 2017 ($Million)
Table 5 Overall NGS Market, By Geography, 2010 – 2017 ($Million)
Table 6 Global Pre-Sequencing Market, By Process,2010 – 2017 ($Million)
Table 7 Pre-Sequencing Market, By Geography, 2010 – 2017 ($Million)
Table 8 Global NGS Product Market, By Company Brand, 2010 – 2017 ($Million)
Table 9 Illumina NGS Platform Market, By Geography, 2010 – 2017 ($Million)
Table 10 Illumina NGS Consumables/Reagents Market, By Geography, 2010 – 2017 ($Million)
Table 11 Illumina NGS Services Market, By Geography, 2010 – 2017 ($Million)
Table 12 Hiseq Series Market, By Geography, 2010 – 2017 ($Million) 94
Table 13 Genome Analyzer Iix Market, By Geography, 2010 – 2017 ($Million)
Table 14 Hiscansq Market, By Geography, 2010 – 2017 ($Million)
Table 15 Miseq Market, By Geography, 2010 – 2017 ($Million)
Table 16 Life Technologies NGS Platform Market, By Geography, 2010 – 2017 ($Million)
Table 17 Life Technologies NGS Consumables/Reagents Market, By Geography, 2010 – 2017
($Million)
Table 18 Life Technologies NGS Services Market, By Geography, 2010 – 2017 ($Million)
Table 19 Solid Series Market, By Geography, 2010 – 2017 ($Million)
Table 20 Ion Pgm Market, By Geography, 2010 – 2017 ($Million)
Table 21 Ion Proton Market, By Geography, 2010 – 2017 ($Million)
Table 22 454 Roche NGS Platform Market, By Geography, 2010 – 2017 ($Million)
Table 23 454 Roche NGS Consumables/Reagents Market, By Geography, 2010 – 2017
($Million)
Table 24 454 Roche NGS Services Market, By Geography, 2010 – 2017 ($Million)
Table 25 GS Junior Market, By Geography, 2010 – 2017 ($Million)
Table 26 GS FLX+ Market, By Geography, 2010 – 2017 ($Million)
Table 27 Pacific Biosciences NGS Platform Market, By Geography, 2010 – 2017 ($Million)
Table 28 Pacific Biosciences NGS Consumables/Reagents Market, By Geography, 2010 – 2017
($Million)
Table 29 Pacific Biosciences NGS Services Market, By Geography, 2010 – 2017 ($Million)
Table 30 Pacbio Rs Ii Market, By Geography, 2010 – 2017 ($Million)
Table 31 NGS Sequencing Services Market, By Geography, 2010 – 2017 ($Million)
Table 32 Global NGS Data Analysis Market, By Product, 2010 – 2017 ($Million)
Table 33 NGS Data Analysis Market, By Geography, 2010 – 2017 ($Million)
Table 34 NGS Data Analysis Software & Workbenches Market, By Geography, 2010 – 2017
($Million)
Table 35 Global NGS Data Analysis Software & Workbenches Market, By Application, 2010 –
2017 ($Million)
Table 36 NGS Data Analysis Services Market, By Geography, 2010 – 2017 ($Million)
Table 37 Global NGS Data Services Market, By Application, 2010 – 2017 ($Million)
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Table 38 Global NGS Data Analysis Market, By Application, 2010 – 2017 ($Million)
Table 39 Global NGS Technology, By Company
Table 40 Global NGS Market, By Technology, 2010 – 2017 ($Million)
Table 41 SBS Technology Market, By Geography, 2010 – 2017 ($Million)
Table 42 Ion Semiconductor Sequencing Technology Market, By Geography, 2010 – 2017
($Million)
Table 43 SBL Technology Market, By Geography, 2010 – 2017 ($Million)
Table 44 Pyrosequencing Technology Market, By Geography, 2010 – 2017 ($Million)
Table 45 SMRT Technology Market, By Geography, 2010 – 2017 ($Million)
Table 46 Global NGS Market, By Application, 2010 – 2017 ($Million)
Table 47 Diagnostics NGS Market, By Geography, 2010 – 2017 ($Million)
Table 48 Drug Discovery NGS Market, By Geography, 2010 – 2017 ($Million)
Table 49 Biomarker Discovery NGS Market, By Geography, 2010 – 2017 ($Million)
Table 50 Personalized Medicine NGS Market, By Geography, 2010 – 2017 ($Million)
Table 51 Agriculture & Animal Research NGS Market, By Geography, 2010 – 2017 ($Million)
Table 52 Other Applications NGS Market, By Geography, 2010 – 2017 ($Million)
Table 53 NGS Presequencing Market, By Geography, 2010 – 2017 ($Million)
Table 54 NGS Market, By Geography, 2010 – 2017 ($Million)
Table 55 NGS Bioinformatics Market, By Geography, 2010 – 2017 ($Million)
Table 56 North America: NGS Market, By Product, 2010 – 2017 ($Million)
Table 57 North America: NGS Product Market, By Company Brand, 2010 – 2017 ($Million)
Table 58 North America: NGS Market, By Technology, 2010 – 2017 ($Million)
Table 59 North America: NGS Market, By Application, 2010 – 2017 ($Million)
Table 60 North America: NGS Bioinformatics Market, By Product, 2010 – 2017 ($Million)
Table 61 Europe: NGS Market, By Product, 2010 – 2017 ($Million)
Table 62 Europe: NGS Product Market, By Company Brand, 2010 – 2017 ($Million)
Table 63 Europe: NGS Market, By Technology, 2010 – 2017 ($Million)
Table 64 Europe: NGS Market, By Application, 2010 – 2017 ($Million)
Table 65 Europe: NGS Bioinformatics Market, By Product, 2010 – 2017 ($Million)
Table 66 Asia: NGS Market, By Product, 2010 – 2017 ($Million)
Table 67 Asia: NGS Product Market, By Company Brand, 2010 – 2017 ($Million)
Table 68 Asia: NGS Market, By Technology, 2010 – 2017 ($Million)
Table 69 Asia: NGS Market, By Application, 2010 – 2017 ($Million)
Table 70 Asia: NGS Bioinformatics Market, By Product, 2010 – 2017 ($Million)
Table 71 Row: NGS Market, By Product, 2010 – 2017 ($Million)
Table 72 Row: NGS Product Market, By Company Brand, 2010 – 2017 ($Million)
Table 73 Row: NGS Market, By Technology, 2010 – 2017 ($Million)
Table 74 Row: NGS Market, By Application, 2010 – 2017 ($Million)
Table 75 Row: NGS Bioinformatics Market, By Product, 2010 – 2017 ($Million)
Table 76 Mergers & Acquisitions, 2011 – 2013)
Table 77 Agreements, Partnerships, Collaborations, Contracts & Joint Ventures, 2011 – 2013
Table 78 New Product Launch, 2011 – 2013
Table 79 Expansion, 2011 – 2013
Table 80 ROCHE: Total Revenue, By Segment 2010 – 2012 ($Million)
Table 81 Agilent Technologies, Inc.: Total Revenue, By Segment, 2010 – 2012 ($Million)
Table 82 EMC Corporation: Total Revenue, By Segment, 2010 – 2012 ($Million)
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Table 83 Illumina, Inc.: Total Revenue, By Segment, 2010 – 2012 ($Million)
Table 84 Life Technologies Corporation: Total Revenue, By Segment, 2010 – 2012 ($Million)
Table 85 Pacific Biosciences Of California: Total Revenue, By Segment, 2010 – 2012 ($Million)
Table 86 Perkinelmer, Inc.: Total Revenue, By Segment, 2010 – 2012 ($Million)
Table 87 Qiagen N.V.: Total Revenue, By Segment, 2010 – 2012 ($Million)
List Of Figures (24 Figures)
Figure 1 Opportunity Matrix: Global NGS Market, By Product, 2012
Figure 2 NGS Market, By Geography, 2010 – 2017
Figure 3 Evolution Of Genetic Analysis
Figure 4 Market Segmentation Of Next Generation Sequencing (NGS)
Figure 5 Market Dynamics Of Next Generation Sequencing (NGS)
Figure 6 Data Storage & Pricing, 1990 – 2012
Figure 7 Value Chain Analysis For Sequencing Platforms
Figure 8 Global NGS Market, End-User Analysis, 2012 & 2017
Figure 9 Global NGS Market Share Analysis, By Key Players, 2012 & 2017
Figure 10 North America: NGS Market Share Analysis, By Key Player, 2012
Figure 11 Europe: NGS Market Share Analysis, By Key Player, 2012
Figure 12 Asia: NGS Market Share Analysis, By Key Player, 2012
Figure 13 Global NGS Platform Market Share Analysis, By Key Player, 2012
Figure 14 North America: NGS Platform Market Share Analysis, By Key Player, 2012
Figure 15 Europe: NGS Platform Market Share Analysis, By Key Players, 2012
Figure 16 Asia: NGS Platform Market Share Analysis, By Key Player, 2012
Figure 17 Global NGS Bioinformatics Market Share Analysis, By Key Player, 2012
Figure 18 Global Overall NGS Market, Product Market Share, 2010 – 2017 (%)
Figure 19 Global NGS Platform Market, By Company Brand, 2012 & 2017 ($Million)
Figure 20 Global NGS Platform Market, Growth Rate Comparison, 2012 – 2017
Figure 21 Opportunity Matrix: Global NGS Technology Market, 2012
Figure 22 Global NGS Application Market, 2012 & 2017
Figure 23 Key Growth Strategies, 2011 – 2013
Figure 24 Key Players Focusing On New Product Launch, 2011 – 2013
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