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Contents
Part I
1 Drug Safety ......................................... 1
I. Zolle
1.1 Quality Control and COST ........................... 3
1.2 Quality Standards ................................. 4
1.3 Quality Assurance ................................. 4
1.4 Quality Control of Kit Products ........................ 4
1.5 European Economic Community Directives and Regulations .... 5
2 Technetium in Medicine ................................. 7
2.1
99m
Technetium Chemistry
U. Mazzi
........................... 7
2.1.1 Technetium Compounds and their Structures ............... 8
2.1.2 Technetium(V) Complexes ........................... 9
2.1.3 Technetium(IV), (III), and (I) Complexes ................... 17
2.1.4
99m
Tc Labeling ................................... 20
2.2 Technetium and Rhenium Tricarbonyl Core
R. Schibli
.............. 27
2.2.1 Bioconjugates Comprising the M(CO)3 Core ................ 32
2.3 Technetium Coupled With Biologically Active Modules ........
H.-J. Pietzsch, J.-U. Kçnstler and H. Spies
40
2.3.1 Introduction ..................................... 40
2.3.2 Factors Affecting In Vivo Performance .................... 41
2.3.3 Chelate Units in the Design of Target-Specific 99m Tc
Pharmaceuticals .................................. 42
2.3.4 Search for Novel Tc Pharmaceuticals ..................... 46
3 Stannous Chloride in the Preparation of 99m Tc Pharmaceuticals ..... 59
H. Spies, H.-J. Pietzsch
3.1 Introduction .................................... 59
3.2 Stannous Chloride: the Preferred Reducing Agent
for Tc Pharmaceuticals ............................. 61