CMiST the first four months 2017

CMiST
the first four months

Who we are.....................................page 2, 3
What we are doing...................page 4, 5
Partnerships.......................................page 6
Online presence.............................page 7
right now

Who we are right now
The Center for Microbiome Sciences & Therapeutics (CMiST) will serve as a hub of collaboration and connectivity
for researchers and clinicians at the University of Washington and its affiliated campuses.
5UW SCHOOLS & COLLEGES
College of Engineering
School of Art + Art History + Design
School of Medicine
School of Nursing
School of Public Health
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UW DEPARTMENTS & DIVISIONS
Behavioral Nursing
Comparative History of Ideas
Comparative Medicine
Epidemiology
Global Health
Human Centered Design & Engineering
Immunology
Medicine, Allergy and Infectious Disease
Medicine, Gastroenterology
Medicine, Metabolism, Endocrinology and Nutrition
Medicine, Pediatrics
Microbiology
Pharmacy
Photomedia
Inspire Discovery | 2
“Do stuff. Be clenched, curious. Not waiting for inspiration’s shove or society’s kiss on your forehead. Pay attention.
It’s all about paying attention. Attention is vitality. It connects you with others. It makes you eager. Stay eager.”
-Susan Sontag, American writer, film-maker, teacher, and political activist

22
UW FACULTY
BIOBEHAVIORAL NURSING
Margaret Heitkemper, PhD, RN, FAAN | Dept. Chair,
Endowed Professor
COMPARATIVE HISTORY OF IDEAS
Thurtle, Philip, PhD | Associate Professor
COMPARATIVE MEDICINE
Maggio-Price, Lillian, VMD, PhD | Dept. Vice Chair, Professor
EPIDEMIOLOGY
Walson, Judd, MD, PhD | Adjunct Associate Professor
GLOBAL HEALTH
Pavlinac, Patricia, PhD | Assistant Professor
Walson, Judd, MD, PhD | Associate Professor
HUMAN CENTERED DESIGN & ENGINEERING
Fox, Tyler, PhD | Lecturer
IMMUNOLOGY
Gale, Michael, Jr. PhD | Professor, Director CIIID
MEDICINE, ALLERGY & INFECTIOUS DISEASE
Walson, Judd, MD, PhD | Associate Professor
MEDICINE, GASTROENTEROLOGY
DePaolo, William, PhD | Associate Professor, Endowed Chair, UW GI, Director, CMiST
Grady, William, MD | Endowed Professor, Medical Dir GI Prevention Program Clinic
Inadomi, John, MD | Professor, Head of Division GI
Ko, Cynthia, MD, MS | Associate Professor
Lee, Scott, MD | Associate Professor
Strate, Lisa, MD, MPD | Associate Professor, Director Clinical Research
Yu, Lei, MD | Associate Professor
Zisman, Timothy, MD, MPH | Associate Professor
Bambha, Kiran, MD, MSc | Assistant Professor
Zia, Jasmine, MD | Assistant Professor
MEDICINE, METABOLISM, ENDOCRINOLOGY AND NUTRITION
Hampe, Christiane, PhD | Associate Professor
MEDICINE, PEDIATRIC
Suskind, David, MD | Professor
Walson, Judd, MD, PhD | Associate Professor
MICROBIOLOGY
Hoffman, Lucas, MD, PhD | Associate Professor, Pediatrics,
Adjunct Associate Professor, Microbiology
PHARMACY
Klatt, Nicole, PhD | Assistant Professor
PHOTOMEDIA
Cummins, Rebecca, PhD | Dept. Chair, Professor
www.cmistuw.org | 3

What we are working on right now
Through careful analysis and holistic approaches, we hope to define new pathways, identify new targets and
gain mechanistic insight into the relationship between our environment, our genes and the microbiome.
IBD-FOCUSED PROJECTS
OTHER PROJECTS
PEDIATRIC IBD NUTRITION
David Suskind, MD
DePaolo Lab: Bayaan Haidar
ENTERIC INFECTION AND DIARRHEA
DePaolo Lab: Denise Chac
SPORADIC AND COLITIS ASSOCIATED CANCERS
Cynthia Ko, MD and Bill Grady, MD
DePaolo Lab: Melissa Kordahi
GUT-BRAIN AXIS, IBD STUDIES
Alaskan Native Medical Center
GENETICS AND NUTRITION
Margaret Heitkemper, PhD, RN, FAAN
DePaolo Lab: Andrew Johnson, PhD
CALPROTECTIN AND MICROBIOME ISOLATION
ILEAL RESECTION AND RECURRENCE
Scott Lee, MD
DePaolo Lab: Bayaan Haidar
It has been known that diet is one of the biggest factors that can influence
the microbiome,” DePaolo says, adding that while it’s “amazing to
see how one thing can change the architecture of the gut,” the nutritional
education of one’s microbiome takes time. “Your diet has to slowly change
your microbiome. If you just take a new microbiome and try to stick it in
with a Western diet biome, the consequences can be quite severe.”
-Will
The Whole U Faculty Friday Spotlight, March 2017
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PUBLICATIONS
Kamdar PhD, et al., Regulation of the gut barrier by microbiome
Kim, PhD et al., Targeted probiotic therapy to treat colorectal cancer
Kim, PhD et al., Microbiota regulates intestinal epithelial response in colorectal cancer
Mitsinikos, MD, et al., Microbiome and nutritional modulation to treat non-alcoholic fatty liver disease (NAFLD)
Lakhole, MD, et al., Phenotypic and genetic difference in Hispanic pediatric IBD patients
Lakhole, MD et al., Innate immunity and pediatric IBD
Kordahi and DePaolo, PhD, book chapter: Microbiome and colorectal cancer
Johnson, PhD and DePaolo, PhD, commentary: Microbiome and allergy
GRANT SUBMISSIONS
HIV and EPEC | R21, NIH, National Institute of Allergy and Infectious Disease (NIAID)
Diet and infection | R01, NIH, National Center for Complementary and Integrative Health (NCCIH)
Ileal resection study | Rainin Foundation
IBD and innate genetics | R01, NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
TLR2 and IBD | Allen Foundation
Center of Excellence for Research on Complementary and Integrative Health | P01, NIH, NCCIH
Fiber and infection | F31 (training grant, Denise Chac, DePaolo Lab)
INVITED TALKS
May 2016 | UW Global WACh Current Topics and Methods in Microbiome Research Workshop
November 2016 | UW CFAR New Faces seminar series
November 2016 | American Society Microbiology, Annual Microbes Meeting
January 2017 | UW Global WACh Breakfast with WACh talk series
April 2017 | Translational Microbiome Conference, Boston, MA
April 2017 | University of Wisconsin, Dept. Pathology, Genetics, IBD and leaky gut
May 2017 | UW GI New Frontiers series
May 2017 | UW School of Art, joint talk with CMiST artist-in-residence
June 2017 | UW The Whole U nutrition series
www.cmistuw.org | 5

UW partnerships right now
UW GNOTOBIOTIC ANIMAL CORE (GNAC)
GNAC has successfully rederived germ-free mice for one of the strains
in DePaolo Lab. CMiST will aggressively promote GNAC’s services
and use them exclusively for all CMiST collaborative projects requiring
germ-free mouse models.
GLOBAL WACH
CMiST and Global WACh (women, adolescent and child health) will
host an annual microbiome workshop with invited speakers and
poster session. The inaugural event will be early spring 2018 (date
TBD).
THE WHOLE U
CMiST has developed a nutrition talk series for the Whole U for both
UW faculty and staff, but also the general community, that will
begin June 2017. Will is going to present on various “hot topics,”
including probiotics, fad diets and food additives, and their impact
on the gut microbiome. This talk series will set the foundation for a
collaborative four-week program for UW faculty and staff during
National Nutrition Monday, March 2018.
The Whole U and Nutrition Services have offered their support
for small talks for IBD patients and their families in the CMiST office
suite.
The Whole U, UW Medicine Nutrition Services (Dir. Chuck Zielinski),
HR (Mindy Kornberg, VP UW HR) and CMiST will work together
to submit an NIH P01 program grant together in 2018.
UW SCHOOL OF ART (UW SOA)
CMiST and several UW School of Art (UW SOA) faculty will work together
to develop an art and science curriculum for the 2018 UW undergraduate
Early Fall Start program. This will be a four-week intensive
at the Friday Harbor Laboratories on San Juan Island. This course will
be lead by faculty from various fields of art and science. The program
will culminate in a final two-day symposium.
CIIID
CMiST and The Center for Innate Immunity and Immune Disease will
continuously promote one another and collaborate on a variety of
projects.
Industry partnerships right now
TACONIC BIOSCIENCES
Taconic Biosciences, an industry leader in rodent models for over 60
years, has approached CMiST for future collaboration as they continue
to develop and refine their microbiome portfolio.
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Online presence right now
WEBSITE ANALYTICS SINCE LAUNCH ON JAN 1, 2017
SOCIAL MEDIA
Unique visitors
538
Visits
Page views
839 2,296
We recognize the importance of a strong social
media presence and will continue to build
our online community using primarily Twitter
and Instagram. Other platforms include / will
include Facebook, Pinterest, Flickr and LinkedIn.
Our goal is to create a meaningful engagement
with our followers, including those from
the UW community. Our budding partnership
with The Whole U began from a simple Tweet.
@cmist_uw
Visits by source
Page popularity
“Social media is not just a spoke on the wheel of marketing. It’s becoming the way entire bicycles are built.”
-Ryan Lilly, author and business incubation professional
www.cmistuw.org | 7

SEPT-OCT 2016
Many meetings
discussing design of
the lab & office suite
DEC 2016
Construction of the
office suite begins
FEB 2017
Move in
APRIL 2017
Experiments
begin!
building a space to inspire discovery
NOV 2016
Construction on
the labs begins
JAN 2017
Move from SoCal
to the PNW
FEB 2017
New equipment
arrives
MARCH 2017
The lab receives training on
all of the new equipment
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Our values
THINK DEEPLY
Too often the road with the least resistance is taken,
but true innovation means looking past the obvious
and not accepting answers at face value. Being able
to think deeply means being open to all possibilities,
thinking outside of the box and understanding that
defining the relationship between our cells and our
microbes has far reaching consequences that impact
global health.
CULTIVATE RELATIONSHIPS
Cures begin with passion, but not one person can do it alone.
Opening up a dialogue between clinicians and scientists
may seem like a no-brainer, but for two occupations working
towards the same goal, sometimes it’s as if they are speaking
different languages.
From our location on the UWMC campus and under the
Department of Medicine, CMiST will provide a resource and
a forum by which clinicians and scientists can share their
work, their experiences and develop scientific relationships
that will not only benefit one another, but also our patients.
EMBRACE CREATIVITY
To create cutting-edge technologies, pioneer scientific
breakthroughs and develop new lines of biotherapeutics
creativity is key. CMiST will provide an environment
where creativity and innovation thrive in order
to inspire its members and educate the community.
FACILITATE DISCOVERY
In order to understand a complicated organ like the intestine
and its microbial inhabitants a multidisciplinary team of investigators
and cutting edge technologies is needed. CMiST
will act as a catalyst to allow the exchange of ideas.
always
www.cmistuw.org | 9

CMiST
Inspire Discovery
www.cmistuw.org | Twitter & Instagram @cmist_uw | #microbiomematters