Boclet Final_500

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Lecture 1 “Colloids on The Right Track” Prof. Magdy Khalil Professor of Anesthesia & Intensive Care Menofia University, Egypt Main messages: Differentiate between HES products’ generation and how the MW & MS reflect on the pharmacodynamics of the products. EMA & FDA warning based on Studies in ICU patients. ICU patients are different from surgical patients. It’s not right to extrapolate data from one to another clinical situation. Many recent studies and publication confirm safety of Voluven in surgical settings in term of blood loss, renal function and mortality. “It’s not right to extrapolate data from one to another clinical situation.” (Prof. Khalil) Conclusion: • Fluid therapy is a drug therapy. • Colloids are not the same. • Colloids as any drug have advantages and side-effects. • Any side-effects should be weighed against benefits. Take home messages: • That 6% HES 130/0.4 when given perioperatively to compensate for an acute blood loss can be given without a clinically relevant risk of: • Increased bleeding • Complications • Renal impairment • Mortality
Lecture 2 “ERAA/ERAS & GDFT” Prof. Abdel Azeem Eldawlatly Professor of Anesthesia College of Medicine, King Saud University Riyadh, Saudi Arabia Main messages: Anesthesia play an important role in ERAS protocols. GDFT is a corner stone to optimize organ perfusion and improving surgical outcome. GDFT is done through hemodynamic monitoring Glycocalyx degradation causes microvascular perfusion failure. HES130/0.4 is associated with better impact on small intestinal mucosa integrity compared to RL. HES 130/0.4 is associated with lower fluid balance compared to crystalloids. HES 130/0.4 does not result in significant differences in microvascular reactivity or endothelial glycocalyx degradation unlike crystalloids. Among ICU patients with hypovolemia, 90-day mortality was lower among patients receiving colloids compared to crystalloids. Novel Adjunct Drugs such as adenosine-lidocaine-Magnesium (ALM), beta-hydroxybutyrate plus melatonin (BHB/M), and poloxamer 188 (P-188) Reverse Endothelial Glycocalyx Damage After Hemorrhagic Shock. Take home messages: • ERAA is the core of ERAS. • Fluids play important role in optimize organ perfusion and improving surgical outcome. • Advanced hemodynamic monitoring is important to be implemented. • More research on the effect of different fluid and drugs on Glycocalyx are needed. “Fluids play an important role in optimize organ perfusion and improving surgical outcome.” (Prof. Eldawlatly) “More research on the effect of different fluid and drugs on Glycocalyx are needed.” (Prof. Eldawlatly)
Page 1 and 2: Fresenius Kabi Middle East Scientif
Page 3 and 4: Introduction Introduction Fresenius
Page 5 and 6: Lecture 1 “Omega-3 FA” Dr. Khal
Page 7 and 8: Lecture 3 “Importance of Taurine
Page 9 and 10: Lecture 1 “New advances in oncolo
Page 11 and 12: Lecture 1 “Clinical rational and
Page 13 and 14: Lecture 3 “Supplemental parentera
Page 15 and 16: Lecture 1 “Role of nutrition supp
Page 17 and 18: Lecture 3 “Case scenario 2” Ms.
Page 19: “Time Always Matters” Saturday,
Page 23 and 24: Lecture 4 “Fluid Management in Ca
Page 25: Lecture 6 “Fluid Management and S

Boclet Final_500

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