RESEARCH AND REVIEW PAPERS (main research areas only ...

RESEARCH AND REVIEW PAPERS (main research areas only) 

Prof. Dr. Hans Leuenberger, 

University of Basel, Pharmaceutical Technology Dienstag, 14. November 2006 

Main research areas 

A - Formulation Research 

• 

• 

• 

• 

• 

Application of Percolation Theory and Fractal Geometry 

Drug Delivery Systems 

Experimental Design; Surface Response Methodology Artificial 

Neural Networks; Expert Systems, Multimedia 

PAT-related topics 

Solubility and Structure of Water 

B - Process Technologies Research 

• 

• 

• 

• 

Agglomeration and Granulation 

Compressibility/Compactibility 

Drying 

New Process Technologies and Nanocomposite systems 

C - Powder Technology in General 

• 

Powder Technology 



Percolation theory - a novel approach to solid dosage form design 

Leuenberger Hans, Rohera B., Haas C. 

Publication, in english 

Int.J.Pharm. 38 (1.3), 1987, 109-115. 

ISSN 0378-5173. 

The relationship between solid fraction and mechanical properties of compacts - The percolation 

theory model approach 

Holman Lovelace, Leuenberger Hans 


Int.J.Pharm. 46 (1.2), 1988, 35-44. 

ISSN 0378-5173. 

Monitoring the granulation process: granulate growth, fractal dimensionality and percolation 

threshold 

con riassunto 

Leuenberger Hans, Usteri Mathias, Imanidis Georgios, Winzap Stefan 


Boll.Chem.Farm 128 1989, 54-61. 

1987 International Symposium on Perspectives in solid dosage form design; Pavia 28.9.1987 - 29.9.1987. 

RESEARCH AND REVIEW PAPERS 

1 A - Formulation Research



Percolation Theory, Fractal Geometry, and Dosage Form Design 

Leuenberger Hans, Holman Lovelace, Usteri Mathias, Winzap Stefan 


Pharm.Acta Helv. 64 (2), 1989, 34-39. 

ISSN 0031-6865. 

Fractal Dimension of Pores and Drug Dissolution from Suspension Matrices 

Bonny Jean Daniel, Usteri Mathias, Leuenberger Hans 


Acta Pharm.Techn. 36 (1), 1990, 36-36. 

ISSN 0340-3157. 

Fractal Dimension of porous solid dosage forms 

Usteri Mathias, Bonny Jean Daniel, Leuenberger Hans 



ISSN 0031-6865. 

Percolation theory and compactibility of binary powder systems 

Blattner Dieter, Kolb Max, Leuenberger Hans 


Pharm.Res. 7 (2), 1990, 113-117. 

ISSN 0724-8741. 

The effect of varying the composition of binary powder mixtures and compacts on their properties: A 

percolation phenomenon 



Powder Technol. 60 (3), 1990, 249-258. 

ISSN 0032-5910. 

Matrix type controlled release systems: I. Effect of percolation on drug dissolution kinetics 

Bonny Jean Daniel, Leuenberger Hans 


Pharm.Acta Helv. 66 (5.6), 1991, 160-164. 

ISSN 0031-6865. 

Application of percolation theory and fractal geometry to tablet compaction 

Leuenberger Hans, Leu-Marseiler Ruth, Bonny Jean Daniel 

Publication 

Drug Dev.Ind.Pharm 18 (6.7), 1992, 723-766. 

ISSN 0363-9045. 

Formation of a Tablet: A Site-Bond Percolation Phenomenon 

Leuenberger Hans, Leu-Marseiler Ruth 


J.Pharm.Sci. 81 (10), 1992, 976-982. 

ISSN 0022-3549. 





Determination of Fractal Dimension of Matrix-Type Solid Dosage Forms and their Relation with Drug 

Dissolution Kinetics 

Dedicated to Prof.Dr. Heinz B. Sucker on the occasion of his 65th anniversary 



Eur.J.Pharm.Biopharm. 39 (1), 1993, 31-37. 

ISSN 0939-6411. 

Matrix type controlled release systems: II. Percolation Effects in Non-Swellable Matrices 



Pharm.Acta Helv. 68 1993, 25-33. 

ISSN 0031-6865. 

The application of percolation theory to the compaction of pharmaceutical powders 

Leu-Marseiler Ruth, Leuenberger Hans 


Int.J.Pharm. 90 (3), 1993, 213-219. 

ISSN 0378-5173. 

Study of the release mechanism of carteolol inert matrix tablets on the basis of percolation theory 

Caraballo Isidoro, Fernandes- M., Holgado M.A., Rabasco Antonio M., Leuenberger Hans 


Int.J.Pharm. 109 (3), 1994, 229-236. 

ISSN 0378-5173. 

Use of Percolation Theory to Interpret Water Uptake, Disintegration Time and Intrinsic Dissolution 

Rate of Tablets Consisting of Binary Mixtures 

Luginbühl René, Leuenberger Hans 



ISSN 0031-6865. 

Percolation effects in matrix-type controlled drug release systems 

Leuenberger Hans, Bonny Jean Daniel, Kolb Max 


Int.J.Pharm. 115 (2), 1995, 217-224. 

ISSN 0378-5173. 

Study of percolation thresholds in ternary tablets 

Caraballo Isidoro, Fernandes- M., Millán Monica, Rabasco Antonio M., Leuenberger Hans 


Int.J.Pharm. 139 (1.2), 1996, 177-186. 

ISSN 0378-5173. 

Zero-order release periods in inert matrices. Influence of the distance to the percolation threshold 

Caraballo Isidoro, Millán Monica, Rabasco Antonio M., Leuenberger Hans 



ISSN 0031-6865. 





Application of Percolation Theory to Characterize the Release Behaviour of Carteolol Matrix Systems 

Caraballo Isidoro, Holgado M.A., Fernandes- M., Millán Monica, Rabasco Antonio M. 


Drug Dev.Ind.Pharm 23 (1), 1997, 1-8. 

ISSN 0363-9045. 

Percolation theory and physics of compression 

Leuenberger Hans, Ineichen Lotti 



ISSN 0939-6411. 

Modified Young's Modulus of Microcrystalline Cellulose Tablets and the Directed Continuum 

Percolation Model 

Kuentz Martin, Leuenberger Hans 


Pharm.Dev.Technol. 3 (1), 1998, 13-19. 

ISSN 1083-7450. 

Orden en sistemas farmacéuticos complejos formados por medios desordenados 

Leuenberger Hans 

Inaugural Lecture, in spanish 

Inaugural Lecture 1998. 

1998 Inauguration at the Royal Academy of Pharmacy of Spain; Madrid 5.3.1998 - 5.3.1998. 

Order in Complex Pharmaceutical Systems of Disordered Media 

English Version of:Orden en sistemas farmacéuticos complejos formados por medios desordenados 


Inaugural Lecture, in english 

Inaugural Lecture 1998. 

1998 Inauguration at the Royal Academy of Pharmacy of Spain; Madrid 5.3.1998 - 5.3.1998. 

Elasticity of polymer tablets considered as a network of contacts 

Kuentz Martin, Leuenberger Hans, Kolb Max 


S.T.P.Pharma Sci. 9 (6), 1999, 531-538. 

ISSN 1157-1489. 

Percolation theory, conductivity and dissolution of hydrophilic suppository bases (PEG systems) 

Siegmund Christian, Leuenberger Hans 


Int.J.Pharm. 189 (2), 1999, 187-196. 

ISSN 0378-5173. 

The application of percolation theory in powder technology 


Publication - Invited review 

Advanced Powder Technol. 10 (4), 1999, 323-352. 

ISSN 0921-8831. 





A novel approach to the characterization of polar liquids Part 1: Pure liquids 

Stengele Andrea, Rey Stephanie, Leuenberger Hans 


Int.J.Pharm. 225 (1.2), 2001, 123-134. 

ISSN 0378-5173. 

A novel approach to the characterization of polar liquids Part 2: Hydrophilic Solutions 



Int.J.Pharm. 241 (2), 2002, 231-240. 

ISSN 0378-5173. 

Compression behaviour of the enzyme β-galactosidase and its mixture with microcrystalline cellulose 

Kuny Tanja, Leuenberger Hans 


Int.J.Pharm. 260 (1), 2003, 137-147. 

ISSN 0378-5173. 

Detection of percolation phenomena in binary polar liquids by broadband dielectric spectroscopy 

Hernandez Perni Maria Engracia, Stengele Andrea, Leuenberger Hans 


Int.J.Pharm. 291 (1.2), 2005, 197-209. 

ISSN 0378-5173. 


Realisation et développement de formes médicamenteuses à libération contrôlée par des films 

méthacryliques (2ème comm.). Etude par analyse orthogonale des facteurs influençant le transport 

travers un film plan 

Realization and development of controlled-release drug forms using methacrylate films. 2. Study using orthogonal analysis of factors 

affecting transport across a planar film 

Gurny Robert, Buri P., Sucker Heinz, Guitard P., Leuenberger Hans 

Publication, in french 


ISSN 0031-6865. 

Réalisation et développement de formes médicamenteuses à libération contrôlée par des films 

méthacryliques (4ème comm.). 

Etude par régression linéare multiple de facteurs technologiques influençant la libération d'un principe actif à partir de micro-granules 

enrobés paf fluidisation 

Gurny Robert, Buri P., Sucker Heinz, Guitard P., Leuenberger Hans 



ISSN 0031-6865. 

Grundlagen der Wirkstofffreisetzung aus Transdermalen Arzneiformen 


Publication, in german 

Journal für PharmatechnologieISSN 0931-9700. 

PharmaTechnologie 9 (2), 1988, 18-24. 

ISSN 0931-9700. 

1986 Nov. CONCEPT-Symposium; Frankfurt a.M. 13.11.1986 - 14.11.1986. 





Fractal Dimension of Pores and Drug Dissolution from Suspension Matrices 

Bonny Jean Daniel, Usteri Mathias, Leuenberger Hans 



ISSN 0340-3157. 

Fractal Dimension of porous solid dosage forms 

Usteri Mathias, Bonny Jean Daniel, Leuenberger Hans 



ISSN 0031-6865. 

Matrix type controlled release systems: I. Effect of percolation on drug dissolution kinetics 



Pharm.Acta Helv. 66 (5.6), 1991, 160-164. 

ISSN 0031-6865. 

Trends in the production and coating of pharmaceutical granules, pellets and tablets 


Preprint, in english 

Preprint 2nd PARTEC 92 1992, 137-157. 

2nd International Congress for Particle Technology; Nürnberg 24.3.1992 - 25.3.1992. 

Design and optimization approaches in the field of granulation, drying and coating 

Jap. Publ. über den Vortrag von H.Leuenberger am 53rd International Congress of Pharmaceutical Science of FIP, 1993 

Oguchi Toshio 

Publication, in japanese 

Pharm.Technol.Jpn 9 (12), 1993, 13-16. 

ISSN 0910-4739. 

Determination of Fractal Dimension of Matrix-Type Solid Dosage Forms and their Relation with Drug 

Dissolution Kinetics 

Dedicated to Prof.Dr. Heinz B. Sucker on the occasion of his 65th anniversary 




ISSN 0939-6411. 





ISSN 0031-6865. 




Int.J.Pharm. 109 (3), 1994, 229-236. 

ISSN 0378-5173. 





Membrane modulated dissolution of oral drug delivery systems 

Savastano Louis, Leuenberger Hans, Merkle Hans Peter 



ISSN 0031-6865. 

Modelling of Drug Release from Polymer Matrices: Effect of Drug Loading 

Kocova Silvia, Leuenberger Hans 


Int.J.Pharm. 121 (2), 1995, 141-148. 

ISSN 0378-5173. 




Int.J.Pharm. 115 (2), 1995, 217-224. 

ISSN 0378-5173. 

Vehicle-dependent in situ modification of drug release rate in membrane-controlled drug delivery 

Imanidis Georgios, Helbing-Strausak S., Imboden Dieter, Leuenberger Hans 


ISSN 1022-0178. 

Proc.22th Int.Symp.Controlled Release Bioact.Mater. 1995, 380-381. 

An Improved Diffusion Cell Design for Determining Drug Transport Parameters across Cultured Cell 

Monolayers 

Imanidis Georgios, Waldner Christoph, Mettler Christoph, Leuenberger Hans 


J.Pharm.Sci. 85 (11), 1996, 1196-1203. 

ISSN 0022-3549. 

Dissolution properties of praziquantel-ß-cyclodextrin systems 




ISSN 1083-7450. 

Zero-order release periods in inert matrices. Influence of the distance to the percolation threshold 

Caraballo Isidoro, Millán Monica, Rabasco Antonio M., Leuenberger Hans 



ISSN 0031-6865. 

Application of Percolation Theory to Characterize the Release Behaviour of Carteolol Matrix Systems 

Caraballo Isidoro, Holgado M.A., Fernandes- M., Millán Monica, Rabasco Antonio M. 


Drug Dev.Ind.Pharm 23 (1), 1997, 1-8. 

ISSN 0363-9045. 





Dissolution Properties of Praziquantel - PVP Systems 




ISSN 0031-6865. 

Vehicle-dependent in situ modification of membrane-controlled drug release 

Imanidis Georgios, Helbing-Strausak S., Imboden Roger, Leuenberger Hans 


J.Control.Release 51 (1), 1998, 23-34. 

ISSN 0168-3659. 

Effect of Surface Covering of Lactose Carrier Particles on Dry Powder Inhalation Properties of 

Salbutamol Sulfate 

Iida Kotaro, Hayakawa Youhei, Okamoto Hirokazu, Danjo Kazumi, Leuenberger Hans 


Chem.Pharm.Bull. 51 (12), 2003, 1455-1457. 

ISSN 0009-2363. 

Evaluation of Flow properties of Dry Powder Inhalation of Salbutamol Sulfate with Lactose Carrier 



Pharm.Technol.Jpn 19 (3), 2003, 39(359)-46(366). 

ISSN 0910-4739. 

Preparation of Dry Powder Inhalation by Surface Treatment of Lactose Carrier Particles 




ISSN 0009-2363. 

Effect of Surface Layering Time of Lactose Carrier Particles on Dry Powder Inhalation Properties of 

Salbutamol Sulfate 




ISSN 0009-2363. 

Influence of Storage Humidity on the in Vitro Inhalation Properties of Salbutamol Sulfate Dry 

Powder with Surface Covered Lactose Carrier 




ISSN 0009-2363. 

Influence of storage humidity on the in vitro inhalation properties of salbutamol sulfate dry powder 

with surface covered lactose carrier. 

Iida Kotaro, Hayakawa Youhei, Todo Hiroaki, Okamoto Hirokazu, Danjo Kazumi, Leuenberger Hans 



ISSN 0910-4739. 





Preparation of dry powder inhalation with lactose carrier particles surface-coated using a wurster 

fluidized bed 

Iida Kotaro, Todo Hiroaki, Okamoto Hirokazu, Danjo Kazumi, Leuenberger Hans 



ISSN 0009-2363. 

Pharmaceutical Technology: Drug Delivery, Formulation and Process Research 



CHIMIA 60 (1.2), 2006, 40-45. 

ISSN 0009-4293. 

From “Functional Excipients” towards “Drug Carrier Systems” 



Chemistry Today 24 (5), 2006, 64-66. 

ISSN 0392-839X. 

Experimental design and optimization of the hydrogenation process of soybean oil 

Chansanroj Krisanin, Praserthdam Piyasan, Betz Gabriele, Leuenberger Hans, Mitrevej Ampol 


J.DrugDeliveryPharmTechn 16 (3), 2006, 229-234. 

ISSN 1773-2247. 

Experimental Design; Surface Response Methodology Artificial Neural Networks; Expert Systems, Multimedia 

A Factorial Design for Compatibility Studies in Preformulation Work 

Leuenberger Hans, Becher W. 



ISSN 0031-6865. 

Versuchsplanung 


Lecture, in german 

Course notes of the 'GSIA Fortbildungskurs' 1976, 1-16. 

1976/77 GSIA Fortbildungskurs; 3.2.1977 - 3.2.1977. 

Optimisation statistique d'une formulation pharmaceutique 

Guitard P., Leuenberger Hans, Sucker Heinz 


Labo-Pharma - Probl. Tech. 280 1978, 827-837. 

ISSN 0458-5747. 

Versuchsplanung und Scale-up 




1980/81 GSIA Fortbildungskurs; - . 




Experimental Design; Surface Response Methodology Artificial Neural Networks; Expert Systems, Multimedia 

APV Optimierungsstrategien 



Course notes of the 'APV-Kurs' 1982, 1-51. 

Application of Artificial Neural Networks (ANN) in the Development of Solid Dosage Forms 

Bourquin Jacques, Schmidli Heinz, van Hoogevest Peter, Leuenberger Hans 



ISSN 1083-7450. 

Basic Concepts of Artificial Neural Networks (ANN) Modeling in the Application to Pharmaceutical 

Development 




ISSN 1083-7450. 

Advantages of Artificial Neural Networks (ANNs) as alternative modeling technique for data sets 

showing non-linear relationships using data from a galenical study on a solid dosage form. 



Eur.J.Pharm.Sci. 7 (1), 1998, 5-16. 

ISSN 0928-0987. 

Comparison of artifical neural networks (ANN) with classical modeling techniques using different 

experimental designs and data from a galenical study on a solid dosage form 



Eur.J.Pharm.Sci. 6 (4), 1998, 287-301. 

ISSN 0928-0987. 

Pitfalls of artificial neural networks (ANN) modeling technique for data sets containing outlier 

measurements using a study on mixture properties of a direct compressed dosage form. 



Eur.J.Pharm.Sci. 7 (1), 1998, 17-28. 

ISSN 0928-0987. 

Differential scanning calorimetry as a tool for prediction of the compatibility and stability of 

multicomponent drug systems 

Trobradovic Haris, Hadžidedić Šeherzada, Leuenberger Hans, Kocova Silvia, Betz Gabriele 


Int.J.Pharm. 2005. 

ISSN 0378-5173. 





Maximal zulässige Partikelgrösse von Hilfsstoffen in Mischungen für feste Arzneiformen 



Pharm.Ind. 37 (5), 1975, 357-360. 

ISSN 0031-711x. 

Eine Versuchsanordnung zur Messung der elektrostatischen Aufladung von Granulaten 

Leuenberger Hans, Zimmermann Y. 


Pharm.Ind. 38 (9), 1976, 832-836. 

ISSN 0031-711x. 

Elektrostatische Aufladung von Granulaten und freifliessenden Pulvern 

Electrostatic charge of granulates and free-flowing powders 




ISSN 0340-3157. 

Mathematische Modellierung und Optimierung Pharmazeutisch-Technologischer Qualitätsmerkmale 

fester Arzneiformen 

Mathematical modeling and optimizing pharmaceutical, technological quality control of drugs 

Leuenberger Hans, Guitard P., Sucker Heinz 


Pharmazie in unserer Zeit 5 (3), 1976, 65-76. 

ISSN 0048-3664. 

Optimisation statistique d'une formulation pharmaceutique 




ISSN 0458-5747. 

Versuchsplanung und Scale-up 





Scale-up of Granulation Processes with Reference to Process Monitoring 




ISSN 0340-3157. 





ISSN 0031-6865. 





Prozess-Monitoring bei der Emulsionsherstellung; Drehmomentmessung als Inprozesskontrolle bei 

der Emulsionsherstellung 

Randegger R., Imanidis Georgios, Juch R.D., Birrenbach Gerd, Leuenberger Hans 


Pharm.Ind. 56 (7), 1994, 648-654. 

ISSN 0031-711x. 




Int.J.Pharm. 109 (3), 1994, 229-236. 

ISSN 0378-5173. 

Use of Percolation Theory to Interpret Water Uptake, Disintegration Time and Intrinsic Dissolution 

Rate of Tablets Consisting of Binary Mixtures 

Luginbühl René, Leuenberger Hans 



ISSN 0031-6865. 

Modelling of Drug Release from Polymer Matrices: Effect of Drug Loading 



Int.J.Pharm. 121 (2), 1995, 141-148. 

ISSN 0378-5173. 




Int.J.Pharm. 115 (2), 1995, 217-224. 

ISSN 0378-5173. 

Advantages of Artificial Neural Networks (ANNs) as alternative modeling technique for data sets 

showing non-linear relationships using data from a galenical study on a solid dosage form. 



Eur.J.Pharm.Sci. 7 (1), 1998, 5-16. 

ISSN 0928-0987. 

Comparison of artifical neural networks (ANN) with classical modeling techniques using different 

experimental designs and data from a galenical study on a solid dosage form 



Eur.J.Pharm.Sci. 6 (4), 1998, 287-301. 

ISSN 0928-0987. 





Development of a quasi-continuous production line for granules – a concept to avoid scale-up 

problems 

Dörr Benno, Leuenberger Hans 


Preprint,1st Europ.Symp.Process Technology in Pharmac.and Nutrit.Sciences 

1998, 247-256. 

ISBN 3-921-590-55-8. 

1st European Symposium; Process Technology in Pharmaceutical and Nutritional Sciences; Nürnberg 10.3.1998 - 12.3.1998. 

combined with 4th International Congress for Particle Technology 





Eur.J.Pharm.Sci. 7 (1), 1998, 17-28. 

ISSN 0928-0987. 

How to Avoid Scale-up Problems in Manufacturing Pharmaceutical Granules: The Glatt Multicell 

Concept 

Word file in english 




ISSN 0910-4739. 

New Trends in the Production of Pharmaceutical Granules: Batch versus Continuous Processing 




ISSN 0939-6411. 

New Trends in the Production of Pharmaceutical Granules: The classical batch concept and the 

problem of scale-up 




ISSN 0939-6411. 

Scale-up in the 4th dimension in the field of granualation and drying 



Preprints 7th Intern.Symp.Aggl. 2001, 375-384. 

2001 Atelier Pharmacie; Paris 14.3.2001 - 15.3.2001. 





7th International Symposium on Agglomeration; Albi CT Cedex 29.5.2001 - 31.5.2001. 





WIP/CIP und geschlossene Anlagensysteme im pharmazeutischen Feststoffbereich 

Schiffmann Axel, Luy Bernhard, Bättig Markus, Leuenberger Hans 


Pharm.Ind. 63 (2), 2001, 203-212. 

ISSN 0031-711x. 

Batch and Continuous Processing in the Production of Pharmaceutical Granules 

Betz Gabriele, Junker Bürgin Pascale, Leuenberger Hans 



ISSN 1083-7450. 

Non-destructive Dissolution Testing Correlation 

Kuny Tanja, Schatz Caspar, Ulmschneider Michel, Marrer Stephan, Leuenberger Hans 


Distech 10 (1), 2003, 22-28. 

ISSN 1521-298X. 

Power consumption profile analysis and tensile strength measurements during moist agglomeration 



Int.J.Pharm. 252 (1.2), 2003, 11-25. 

ISSN 0378-5173. 

Scale-up in the 4th dimension in the field of granulation and drying or how to avoid classical scale-up 



Powder Technol. 130 (1.3), 2003, 225-230. 

ISSN 0032-5910. 


Comparative evaluation of the compression behavior of a new cellulose based direct compression 

excipient and Avicel® PH-102 

Reus Marilu, Lanz Michael, Kumar Vijay, Leuenberger Hans 


jpp 56 (8), 2004, 951-956(6). 

ISSN 0022-3573. 

Power Consumption Measurement and Temperature Recording during Granulation 

Int.J.Pharm 



Int.J.Pharm. 272 (1.2), 2004, 137-149. 

ISSN 0378-5173. 

Search for technological reasons to develop a capsule or a tablet formulation with respect to 

wettability and dissolution 

von Orelli Johannes, Leuenberger Hans 


Int.J.Pharm. 287 (1.2), 2004, 135-145. 

ISSN 0378-5173. 





Semicontinuous granulation - the process of choice for the production of pharmaceutical granules? 

Werani Jürgen, Grünberg Mads, Ober Christian, Leuenberger Hans 


Powder Technol. 140SpecIssue (3), 2004, 163-168. 

ISSN 0032-5910. 

1st International Workshop on granulation; Sheffield 14.1.2003 - 15.1.2003. 

Differential scanning calorimetry as a tool for prediction of the compatibility and stability of 

multicomponent drug systems 

Trobradovic Haris, Hadžidedić Šeherzada, Leuenberger Hans, Kocova Silvia, Betz Gabriele 


Int.J.Pharm. 2005. 

ISSN 0378-5173. 

Pharmaceutical Powder Technology - From Art to Science: The Challenge of FDA's PAT Initiative 

Leuenberger Hans, Lanz Michael 



ISSN 0921-8831. 

Spray-freeze drying in a fluidized bed at normal and low pressure 

Plitzko Matthias, Puchkov Maxim, Leuenberger Hans 


DRYING TECHNOLOGY 24 2006, 711-719. 

ISSN 0737-3937. 

Pharmaceutical Technology: Drug Delivery, Formulation and Process Research 



CHIMIA 60 (1.2), 2006, 40-45. 

ISSN 0009-4293. 

From “Functional Excipients” towards “Drug Carrier Systems” 



Chemistry Today 24 (5), 2006, 64-66. 

ISSN 0392-839X. 


Solubility Properties of Racemic Praziquantel and its Enantiomers 

Kocova Silvia, Giron Danièlle, Leuenberger Hans 



ISSN 1083-7450. 

A novel approach to the characterization of polar liquids Part 1: Pure liquids 



Int.J.Pharm. 225 (1.2), 2001, 123-134. 

ISSN 0378-5173. 





A novel approach to the characterization of polar liquids Part 2: Hydrophilic Solutions 



Int.J.Pharm. 241 (2), 2002, 231-240. 

ISSN 0378-5173. 

The characterization of aprotic polar liquids and percolation phenomena in DMSO/water mixtures 

Hernandez Perni Maria Engracia, Leuenberger Hans 



ISSN 0939-6411. 

Towards a better understanding of the parameter Ei/E in the characterization of polar liquids 

Hernandez Perni Maria Engracia, Stengele Andrea, Leuenberger Hans 


Int.J.Pharm. 291 (1.2), 2005, 189-195. 

ISSN 0378-5173. 





Bestimmung der optimalen Menge Granulierflüssigkeit durch Messung der elektrischen 

Leistungsaufnahme eines Planetenmischers 

Determination of the optimal amount of granular fluidity by measuring the electrical performance of a rotating mixer 

Bier Hans Peter, Leuenberger Hans 


Acta Pharm.Techn. 7suppl 1979, 41-44. 

ISSN 0340-3157. 

Determination of the uncritical quantity of Granulating liquid by power measurements on planetary 

mixers 

Bier Hans Peter, Leuenberger Hans, Sucker Heinz 


Pharm.Ind. 41 (4), 1979, 375-380. 

ISSN 0031-711x. 

II. Theory of the granulating-liquid requirement in the conventional granulation process 

Leuenberger Hans, Bier Hans Peter, Sucker Heinz 


Pharm.Technol.Int 2 (3), 1979, 35-42. 

ISSN 0164-6826. 

I. Theory of the granulating-liquid requirement in the conventional granulation process 



Pharm.Technol. 3 (6), 1979, 61-68. 

ISSN 0147-8087. 

Theorie und Praxis der Bestimmung des Granulierflüssigkeitsbedarfs beim konventionellen 

Granulieren 



Chem.Ing.Tech 52 (7), 1980, 609-609. 

ISSN 0009-286X. 

Agglomerieren, Tablettieren 



Course notes of the 'DECHEMA-Kurs' 1981, 1-24. 

1981 DECHEMA-Kurs; Frankfurt - . 

Determination of the Liquid Requirement for a Conventional Granulation Process 



German Chemical Engineering 4 (1), 1981, 13-18. 

ISSN 0343-5539. 

Granulation, New Techniques 




ISSN 0031-6865. 


17 B - Process Technologies Research



Steuerung und Überwachung konventioneller Granulierprozesse 

Dürrenberger M., Leuenberger Hans 


Chemische Rundschau 35 (6), 1982, 1-2. 

ISSN 0009-2983. 

Untersuchungen über die Herstellung pharmazeutischer Granulate im Schnellmischer mittels 

Leistungsmessung 

Imanidis Georgios, Leuenberger Hans 

Report, in german 

Course notes of the 'VDI-Berichte' 545 1983, 721-742. 

ISSN 0083-5560. 

Monitoring granulation 1 



Manuf Chemist 55 (5), 1984, 67-71. 

ISSN 0262-4230. 

Monitoring granulation 2 



Manuf Chemist 55 (6), 1984, 53-54. 

ISSN 0262-4230. 

Steuerung der Granulatherstellung im Mischer durch Leistungsmessung 

Control of granulated material production in mixers by performance measurement 

Leuenberger Hans, Imanidis Georgios 


Chem.Ind. XXXVI (5), 1984, 281-284. 

ISSN 0009-2959. 

Untersuchungen über die Herstellung pharmazeutischer Granulate im Schnellmischer mittels 

Leistungsmessung 

Imanidis Georgios, Leuenberger Hans 


Chem.Ing.Tech 56 (4), 1984, 322-323. 

ISSN 0009-286X. 

Agglomeration '85, Bericht über das 4. interdisziplinäre Symposium Agglomeration, 

Toronto/Kanada, 2.-5. Juni 1985 


Report, in german 

Swiss Pharma 7 (7.8), 1985, 13-17. 

ISSN 0251-1673. 

4th International Symposium on Agglomeration; Toronto 2.6.1985 - 5.6.1985. 





Leistungsmessung in der Granulierung 





ISSN 0931-9700. 

1986 Feb. CONCEPT-Symposium; Frankfurt a.M. 25.2.1986 - 26.2.1986. 

Monitoring mass transfer processes to control moist agglomeration 

Leuenberger Hans, Imanidis Georgios 


Pharm.Technol. 10 (3), 1986, 56-73. 

ISSN 0147-8087. 

Aufbauagglomeration sphärischer Granulate 

Studer Jürg, Hirschfeld P, Leuenberger Hans 


Course notes of the 'APV-Seminar' 1987. 

1987 APV-Fortbildungskurs; Hannover 9.11.1987 - 11.11.1987. 

Agglomeration of binary mixtures in a high-speed mixer 

Usteri Mathias, Leuenberger Hans 


Int.J.Pharm. 55 (2.3), 1989, 135-141. 

ISSN 0378-5173. 

Agglomerierverhalten pharmazeutischer Grundstoffe im Schnellmischer insbesondere binärer 

Mischungen 

Agglomeration behavior of pharmaceutical raw materials, especially binary mixtures in fast mixers 



Chem.Ing.Tech 61 (3), 1989, 254-255. 

ISSN 0009-286X. 

Granulation and Drying in Vacuum Fluid Bed Systems: basics and first results in the application of a 

new fluid bed technology 

Luy Bernhard, Hirschfeld P, Leuenberger Hans 


Drugs Germany 32 (3), 1989, 3-8. 

ISSN 0012-6683. 

Granulation with Surfactants: Effect of the Chemical Nature of the Surfactant and the Starting 

Material on the Granulating Liquid Requirement 




ISSN 0340-3157. 





Granulieren und Trocknen in der Vakuum-Wirbelschicht 

Grundlagen und Erfahrungen bei der Anwendung eines neuen Wirbelschichtverfahrens 



Pharm.Ind. 51 (1), 1989, 89-94. 

ISSN 0031-711x. 

Monitoring the granulation process: granulate growth, fractal dimensionality and percolation 

threshold 

con riassunto 

Leuenberger Hans, Usteri Mathias, Imanidis Georgios, Winzap Stefan 


Boll.Chem.Farm 128 1989, 54-61. 

1987 International Symposium on Perspectives in solid dosage form design; Pavia 28.9.1987 - 29.9.1987. 

Prozessteuerung bei Granulat- und Pelletherstellung 





ISSN 0931-9700. 

1989 CONCEPT-Symposium; Frankfurt a.M. 7.3.1989 - 8.3.1989. 

New development in the control of moist agglomeration and pelletization process 

Leuenberger Hans, Luy Bernhard, Studer Jürg 


S.T.P.Pharma Sci. 6 (5), 1990, 303-309. 

ISSN 1157-1489. 

Aufbauagglomeration Teil A: Entwicklungstendenzen im Bereich der Feuchtagglomeration in der 

Pharmaindustrie 

Leuenberger Hans, Ries H.B. 


Referate-GVC/VDI 1991, 167-177. 

1991 GVC/VDI Fachausschuss Agglomerations- und Schüttguttechnik; Baden-Baden 25.11.1991 - 26.11.1991. 

Herstellung von pharmazeutischen Granulaten mit einem kombinierten Feuchtgranulations- oder 

Mehrkammer-Wirbelschichttrocknungsverfahren 

Manufacture (Production) of pharmaceutical granulates in a combined wet granulation and multi-compartment (multiple chamber) 

fluidized-bed drying process 

Schade Andreas, Leuenberger Hans 

Publication - Thesis, in german 

Chem.Ing.Tech 64 (11), 1992, 1016-1018. 

ISSN 0009-286X. 

Trends in the production and coating of pharmaceutical granules, pellets and tablets 



Preprint 2nd PARTEC 92 1992, 137-157. 

2nd International Congress for Particle Technology; Nürnberg 24.3.1992 - 25.3.1992. 







Oguchi Toshio 



ISSN 0910-4739. 

Size Enlargement of Pharmaceutical Powders by Wet Agglomeration and Drying Techniques 



Kona 11 1993, 69-78. 

ISSN 0288-4534. 

Wet spherical agglomeration of proteins as a new method to prepare parenteral fast-soluble dosage 

forms 

Bausch Alexander, Leuenberger Hans 


Int.J.Pharm. 101 (1.2), 1994, 63-70. 

ISSN 0378-5173. 

Pharmaceutical technology and quality assurance: the impact of novel concepts in the production of 

granules and tablets 



S.T.P.Pharma Sci. 7 (1), 1997, 19-25. 

ISSN 1157-1489. 

Development of a quasi-continuous production line for granules – a concept to avoid scale-up 

problems 

Dörr Benno, Leuenberger Hans 


Preprint,1st Europ.Symp.Process Technology in Pharmac.and Nutrit.Sciences 

1998, 247-256. 

ISBN 3-921-590-55-8. 

1st European Symposium; Process Technology in Pharmaceutical and Nutritional Sciences; Nürnberg 10.3.1998 - 12.3.1998. 

combined with 4th International Congress for Particle Technology 

Granulation - Novel Concepts 


Publication/Abstract, in chinese 

AchemAsia '98 1998, 168-169. 

4th International Meeting on Chemical Engineering and Biotechnology; Beijing 11.5.1998 - 16.5.1998. 

How to Avoid Scale-up Problems in Manufacturing Pharmaceutical Granules: The Glatt Multicell 

Concept 

Word file in english 




ISSN 0910-4739. 





New Trends in the Production of Pharmaceutical Granules: Batch versus Continuous Processing 




ISSN 0939-6411. 

New Trends in the Production of Pharmaceutical Granules: The classical batch concept and the 

problem of scale-up 




ISSN 0939-6411. 















ISSN 1083-7450. 

Power consumption profile analysis and tensile strength measurements during moist agglomeration 



Int.J.Pharm. 252 (1.2), 2003, 11-25. 

ISSN 0378-5173. 





ISSN 0032-5910. 



Int.J.Pharm 



Int.J.Pharm. 272 (1.2), 2004, 137-149. 

ISSN 0378-5173. 









ISSN 0032-5910. 



Ausgewählte Grundlagen pharmazeutischer Technologie, Vortragsscriptum "Das Pressen von 

pulverförmigen Haufwerken" 





Zur Theorie der Pulverkompression 

Leuenberger Hans, Leuenberger Hans 

Publication - Habilitation, in german 

Habilitationsschrift Universität Basel 1980, 1-195. 

Agglomerieren, Tablettieren 



Course notes of the 'DECHEMA-Kurs' 1981, 1-24. 

1981 DECHEMA-Kurs; Frankfurt - . 

Das Verdichten pulverförmiger Haufwerke 


Preprint, in german 

Preprints. 3rd Intern.Symp.Aggl. 1981, C 2-C 20. 

3rd International Symposium on Agglomeration; Nürnberg 6.5.1981 - 8.5.1981. 

Ein Beitrag zur Theorie der Pulverkompression 

Contribution to the theory of powder compression 

Leuenberger Hans, Hiestand Everett N., Sucker Heinz 


Chem.Ing.Tech 53 (1), 1981, 45-47. 

ISSN 0009-286X. 

The compressibility and compactibility of powder systems 



Int.J.Pharm. 12 (1), 1982, 41-55. 

ISSN 0378-5173. 

Compressibility and compactibility of powder mixtures 

Jetzer Walter, Leuenberger Hans, Sucker Heinz 


Pharm.Technol. 7 (11), 1983, 33-48. 

ISSN 0147-8087. 





The compactibility of powder systems - a novel approach 

Leuenberger Hans, Jetzer Walter 

Editor(s); Verkooijen Adrian H.M. 


EFCE Publication Series, Volume 28, 

Preprint Int.Symp.Eindhoven 1983, 197-206. 

ISBN 90-9000485-8. 

1983 International Symposium Eindhoven; Eindhoven 29.8.1983 - 31.8.1983. 

The compressibility and compactibility of pharmaceutical powders 



Pharm.Technol. 7 (4), 1983, 33-39. 

ISSN 0147-8087. 

Compressibilité et comprimabilité des substances pharmaceutiques 

Compressibility and tableting of pharmaceuticals 




ISSN 0458-5747. 

Rasterelektronenmikroskopische Untersuchungen von Wechselwirkungseffekten beim Verpressen 

binärer Pulvermischungen 

Jetzer Walter, Düggelin M., Guggenheim R., Leuenberger Hans 



ISSN 0340-3157. 




Powder Technol. 37 1984, 209-218. 

ISSN 0032-5910. 

Zur Bestimmung der Deckeltendenz von pharmazeutischen Wirk- und Hilfsstoffen 

Determination of the capping tendency of pharmaceutical active ingredients and excipients 

Jetzer Walter, Leuenberger Hans 



ISSN 0031-6865. 

Compression of binary powder mixtures and solubility parameters of solids 



Int.J.Pharm. 27 (2.3), 1985, 127-138. 

ISSN 0378-5173. 





Pressgleichungen für binäre Pulvermischungen 

Compaction equation for binary powder mixtures 

Leuenberger Hans, Rohera B. 


Pharm.Acta Helv. 60 (9), 1985, 10-. 

ISSN 0031-6865. 

Ueber das Komprimierverhalten von NaC1, KC1 und Hexamethylentetramin 

Compression characteristics of sodium chloride, potassium chloride and hexamethylenetetramine 




ISSN 0032-5910. 

Fundamentals of Powder Compression I. The compactibility and compressibility of pharmaceutical 

powders 

Leuenberger Hans, Rohera B., Bhagwan Dass 


Pharm.Res. 3 (1), 1986, 12-22. 

ISSN 0724-8741. 

Fundamentals of Powder Compression II. The compression of binary powder mixtures 



Pharm.Res. 3 (2), 1986, 65-74. 

ISSN 0724-8741. 

The relationship between solid fraction and mechanical properties of compacts - The percolation 

theory model approach 



Int.J.Pharm. 46 (1.2), 1988, 35-44. 

ISSN 0378-5173. 

Effect of compression speed on the relationship between normalised solid fraction and mechanical 

properties of compacts 



Int.J.Pharm. 57 (1), 1989, R1-R5. 

ISSN 0378-5173. 

Relation between crushing strength and internal specific surface area of lactose compacts 

Leuenberger Hans, Bonny Jean Daniel, Lerk C.F., Vromans Herman 


Int.J.Pharm. 52 (2), 1989, 91-100. 

ISSN 0378-5173. 








Pharm.Res. 7 (2), 1990, 113-117. 

ISSN 0724-8741. 

The significance of slopes of the semilogarithmic relationship between hardness and solid fraction of 

porous compacts 




ISSN 0032-5910. 

Application of percolation theory and fractal geometry to tablet compaction 

Leuenberger Hans, Leu-Marseiler Ruth, Bonny Jean Daniel 

Publication 

Drug Dev.Ind.Pharm 18 (6.7), 1992, 723-766. 

ISSN 0363-9045. 

The application of percolation theory to the compaction of pharmaceutical powders 

Leu-Marseiler Ruth, Leuenberger Hans 


Int.J.Pharm. 90 (3), 1993, 213-219. 

ISSN 0378-5173. 

Percolation theory and physics of compression 

Leuenberger Hans, Ineichen Lotti 



ISSN 0939-6411. 

Modified Young's Modulus of Microcrystalline Cellulose Tablets and the Directed Continuum 

Percolation Model 




ISSN 1083-7450. 





Eur.J.Pharm.Sci. 7 (1), 1998, 17-28. 

ISSN 0928-0987. 

Pressure susceptibility of polymer tablets as a critical property: A modified Heckel equation 



J.Pharm.Sci. 88 (2), 1999, 174-179. 

ISSN 0022-3549. 





A new model for the hardness of a compacted particle system, applied to tablets of pharmaceutical 

polymers 




ISSN 0032-5910. 

A new theoretical approach to tablet strength of a binary mixture consisting of a well and a poorly 

compactable substance 

Leuenberger Hans, Kuentz Martin 

Publication - Thesis, in english 


ISSN 0939-6411. 

Powder - the fourth state of matter? 




ISSN 0910-4739. 




Int.J.Pharm. 260 (1), 2003, 137-147. 

ISSN 0378-5173. 

Drying 

Granulation and Drying in Vacuum Fluid Bed Systems: basics and first results in the application of a 

new fluid bed technology 



Drugs Germany 32 (3), 1989, 3-8. 

ISSN 0012-6683. 

Granulieren und Trocknen in der Vakuum-Wirbelschicht 

Grundlagen und Erfahrungen bei der Anwendung eines neuen Wirbelschichtverfahrens 



Pharm.Ind. 51 (1), 1989, 89-94. 

ISSN 0031-711x. 

Atmospheric spray-freeze drying: a suitable alternative in freeze-drying technology? 

Mumenthaler Marco, Leuenberger Hans 


Int.J.Pharm. 72 (2), 1991, 97-110. 

ISSN 0378-5173. 




Drying 

Gefriertrocknung in der Wirbelschicht 



Course notes of the 'APV-Kurs' 1992. 

1992 APV-Fortbildungskurs; Travemünde 5.10.1992 - 7.10.1992. 

Herstellung von pharmazeutischen Granulaten mit einem kombinierten Feuchtgranulations- oder 

Mehrkammer-Wirbelschichttrocknungsverfahren 

Manufacture (Production) of pharmaceutical granulates in a combined wet granulation and multi-compartment (multiple chamber) 

fluidized-bed drying process 

Schade Andreas, Leuenberger Hans 

Publication - Thesis, in german 

Chem.Ing.Tech 64 (11), 1992, 1016-1018. 

ISSN 0009-286X. 



Oguchi Toshio 



ISSN 0910-4739. 

Size Enlargement of Pharmaceutical Powders by Wet Agglomeration and Drying Techniques 



Kona 11 1993, 69-78. 

ISSN 0288-4534. 

Effects of Formulation and Process Variables on the Aggregation of Freeze-Dried Interleukin-6 (IL-6) 

After Lyophilization and on Storage 

Lückel Barbara, Helk Bernhard, Bodmer David, Leuenberger Hans 



ISSN 1083-7450. 

Formulations of Sugars with Amino Acids or Mannitol - Influence of Concentration Ratio on the 

Properties of the Freeze-Concentrate and the Lyophilizate 

Lückel Barbara, Bodmer David, Helk Bernhard, Leuenberger Hans 



ISSN 1083-7450. 









Drying 









Pharm.Ind. 63 (2), 2001, 203-212. 

ISSN 0031-711x. 

Spray Freeze Drying - The Process of Choice for low water soluble Drugs? 



J.Nanop.Res. 4 (1.2), 2002, 111-119. 

ISSN 1388-0764. 





ISSN 0032-5910. 


Modeling of Atmospheric Freeze Drying in a Spouted Bed 

Menshutina Natalia V., Korneeva Anastasiya E., Leuenberger Hans 


TFCEAU 39 (6), 2005, 594-598. 

ISSN 0040-5795. 

Modeling of spouted bed spray-freeze drying at atmospheric pressure 


Publication, in engl/russian 

TFCEAU 39 (6), 2005, 594-598. 

ISSN 0040-5795. 

Spray-freeze drying in a fluidized bed at normal and low pressure 

Plitzko Matthias, Puchkov Maxim, Leuenberger Hans 


DRYING TECHNOLOGY 24 2006, 711-719. 

ISSN 0737-3937. 


Albumin Nanospheres as Carriers for Passive Drug Targeting: An Optimized Manufacturing Technique 

Müller Bernhard G., Leuenberger Hans, Kissel Thomas 


Pharm.Res. 13 (1), 1996, 32-37. 

ISSN 0724-8741. 





Preparation of Liposomes Encapsulating Water-Soluble Compounds Using Supercritical Carbon 

Dioxide 

Frederiksen Lene, Anton Klaus, van Hoogevest Peter, Keller Hans Rudolf, Leuenberger Hans 


J.Pharm.Sci. 86 (8), 1997, 921-928. 

ISSN 0022-3549. 

Focus on research in nanoscience and nanotechnology in Switzerland 



J.Nanop.Res. 2 (4), 2000, 391-392. 

ISSN 1388-0764. 

Thermal Sterilization of Heat Sensitive Products using High-Temperature Short-Time Sterilization 

Mann Angelika, Kiefer Markus, Leuenberger Hans 


J.Pharm.Sci. 90 (3), 2001, 275-287. 

ISSN 0022-3549. 




Pharm.Ind. 63 (2), 2001, 203-212. 

ISSN 0031-711x. 

Spray Freeze Drying - The Process of Choice for low water soluble Drugs? 



J.Nanop.Res. 4 (1.2), 2002, 111-119. 

ISSN 1388-0764. 





ISSN 1083-7450. 

Non-destructive Dissolution Testing Correlation 

Kuny Tanja, Schatz Caspar, Ulmschneider Michel, Marrer Stephan, Leuenberger Hans 


Distech 10 (1), 2003, 22-28. 

ISSN 1521-298X. 

Effects on the Quality of Granules Obtained in Conventionally Designed Fluid-bed Equipment 

Compared to Granules Obtained in a Washing In Place/Cleaning In Place Designed Unit 

Schiffmann Axel, Dressler Jochen A., Luy Bernhard, Leuenberger Hans 


Pharm.Ind. 66 (8), 2004, 1024-1030. 

ISSN 0031-711x. 






Int.J.Pharm 



Int.J.Pharm. 272 (1.2), 2004, 137-149. 

ISSN 0378-5173. 





ISSN 0032-5910. 


Development of novel pharmaceutical hydrogenated soybean oil for hot melt coating applications 

Chansanroj Krisanin, Praserthdam Piyasan, Betz Gabriele, Leuenberger Hans, Mitrevej Ampol, Sinchaipanid Nuttanan 


S.T.P.Pharma Sci. 2005. 

ISSN 1157-1489. 

Modeling of Atmospheric Freeze Drying in a Spouted Bed 



TFCEAU 39 (6), 2005, 594-598. 

ISSN 0040-5795. 

Modeling of spouted bed spray-freeze drying at atmospheric pressure 


Publication, in engl/russian 

TFCEAU 39 (6), 2005, 594-598. 

ISSN 0040-5795. 





Eine Versuchsanordnung zur Messung der elektrostatischen Aufladung von Granulaten 



Pharm.Ind. 38 (9), 1976, 832-836. 

ISSN 0031-711x. 

Elektrostatische Aufladung von Granulaten und freifliessenden Pulvern 

Electrostatic charge of granulates and free-flowing powders 




ISSN 0340-3157. 

Ausgewählte Grundlagen pharmazeutischer Technologie, Vortragsscriptum "Das Pressen von 

pulverförmigen Haufwerken" 





Zur Theorie der Pulverkompression 

Leuenberger Hans, Leuenberger Hans 

Publication - Habilitation, in german 

Habilitationsschrift Universität Basel 1980, 1-195. 

Das Verdichten pulverförmiger Haufwerke 


Preprint, in german 

Preprints. 3rd Intern.Symp.Aggl. 1981, C 2-C 20. 

3rd International Symposium on Agglomeration; Nürnberg 6.5.1981 - 8.5.1981. 

Ein Beitrag zur Theorie der Pulverkompression 

Contribution to the theory of powder compression 

Leuenberger Hans, Hiestand Everett N., Sucker Heinz 


Chem.Ing.Tech 53 (1), 1981, 45-47. 

ISSN 0009-286X. 

The compressibility and compactibility of powder systems 



Int.J.Pharm. 12 (1), 1982, 41-55. 

ISSN 0378-5173. 

Compressibility and compactibility of powder mixtures 



Pharm.Technol. 7 (11), 1983, 33-48. 

ISSN 0147-8087. 


32 C - Powder Technology in General





Editor(s); Verkooijen Adrian H.M. 


EFCE Publication Series, Volume 28, 

Preprint Int.Symp.Eindhoven 1983, 197-206. 

ISBN 90-9000485-8. 

1983 International Symposium Eindhoven; Eindhoven 29.8.1983 - 31.8.1983. 

The compressibility and compactibility of pharmaceutical powders 



Pharm.Technol. 7 (4), 1983, 33-39. 

ISSN 0147-8087. 

Compressibilité et comprimabilité des substances pharmaceutiques 

Compressibility and tableting of pharmaceuticals 




ISSN 0458-5747. 

Rasterelektronenmikroskopische Untersuchungen von Wechselwirkungseffekten beim Verpressen 

binärer Pulvermischungen 

Jetzer Walter, Düggelin M., Guggenheim R., Leuenberger Hans 



ISSN 0340-3157. 




Powder Technol. 37 1984, 209-218. 

ISSN 0032-5910. 

Zur Bestimmung der Deckeltendenz von pharmazeutischen Wirk- und Hilfsstoffen 

Determination of the capping tendency of pharmaceutical active ingredients and excipients 




ISSN 0031-6865. 

Compression of binary powder mixtures and solubility parameters of solids 



Int.J.Pharm. 27 (2.3), 1985, 127-138. 

ISSN 0378-5173. 





Pressgleichungen für binäre Pulvermischungen 

Compaction equation for binary powder mixtures 



Pharm.Acta Helv. 60 (9), 1985, 10-. 

ISSN 0031-6865. 

Fundamentals of Powder Compression I. The compactibility and compressibility of pharmaceutical 

powders 

Leuenberger Hans, Rohera B., Bhagwan Dass 


Pharm.Res. 3 (1), 1986, 12-22. 

ISSN 0724-8741. 

Fundamentals of Powder Compression II. The compression of binary powder mixtures 



Pharm.Res. 3 (2), 1986, 65-74. 

ISSN 0724-8741. 

Pharmaceutical technology - High tech or empiricism? 



CHIMIA 40 (6), 1986, 206-216. 

ISSN 0009-4293. 

Wie Basel zur Pharmaziestadt wurde - Geschichten um das Schweizerische Pharmaziehistorische 

Museum 

Historical Importance of Basel in the development of Pharmacology - Exhibits from the Schweizerisches-Pharmaziehistorisches- 

Museum 

Prof.Tadeus Reichstein zum 90. Geburtstag gewidmet 

Leon Laurentia, Leuenberger Hans, Linde Horst H.A. 


CHIMIA 41 (7.8), 1987, 231-240. 

ISSN 0009-4293. 




Pharm.Res. 7 (2), 1990, 113-117. 

ISSN 0724-8741. 

The effect of varying the composition of binary powder mixtures and compacts on their properties: A 

percolation phenomenon 




ISSN 0032-5910. 





Research in solid dosage forms - an obsolet topic? 


Publication - Editorial, in english 

Pharm.Dev.Technol. 2 (3), 1997, VII-VIII. 

ISSN 1083-7450. 

Effect of Separation Characteristics between Salbutamol sulfate (SS) Particles and Model Carrier 

Excipients on Dry Powder for Inhalation 

Iida Kotaro, Leuenberger Hans, Fueg Lise-Marie, Müller-Walz Rudi, Danjo Kazumi 


YaZa 119 (10), 1999, 752-762. 

ISSN 0031-6903. 

Fracture in disordered media and tensile strength of microcrystalline cellulose tablets at low relative 

densities 

Kuentz Martin, Leuenberger Hans, Kolb Max 


Int.J.Pharm. 182 (2), 1999, 243-255. 

ISSN 0378-5173. 

The application of percolation theory in powder technology 


Publication - Invited review 


ISSN 0921-8831. 

Effect of mixing of fine carrier particles on dry powder inhalation property of salbutamol sulfate (SS) 

Iida Kotaro, Leuenberger Hans, Fueg Lise-Marie, Müller-Walz Rudi, Okamoto Hirokazu, Danjo Kazumi 


YaZa 120 (1), 2000, 113-119. 

ISSN 0031-6903. 

Focus on research in nanoscience and nanotechnology in Switzerland 



J.Nanop.Res. 2 (4), 2000, 391-392. 

ISSN 1388-0764. 

Evaluation of flow properties of dry powder inhalation of salbutamol sulfate with lactose carrier. 




ISSN 0009-2363. 

Powder - the fourth state of matter? 




ISSN 0910-4739. 








Int.J.Pharm. 260 (1), 2003, 137-147. 

ISSN 0378-5173. 

Pharmaceutical Powder Technology - From Art to Science: The Challenge of FDA's PAT Initiative 

Leuenberger Hans, Lanz Michael 



ISSN 0921-8831. 


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