ADCs，disulfide linker，cysteine conjugation
Three major components define an ADC—the monoclonal antibody, a cytotoxic payload, and a molecular linker that covalently bridges the other two components. A successful ADC should be chemically and physiologically stable in blood stream, exert similar antigen binding pattern compared with the unconjugated antibody, and exhibit desired payload toxicological effects once internalized.
Three major components define an ADC—the monoclonal antibody, a cytotoxic payload, and a molecular linker that covalently bridges the other two components. A successful ADC should be chemically and physiologically stable in blood stream, exert similar antigen binding pattern compared with the unconjugated antibody, and exhibit desired payload toxicological effects once internalized.
- TAGS
- conjugation
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well-established compounds<br />
From<br />
as MC-vc-PAB-MMAE,<br />
such<br />
SMCC/sulfo-SMCC-maytansinoid<br />
to more innovative<br />
derivatives<br />
sets including peptide<br />
complex<br />
duocarmycin derivative,<br />
linker-based<br />
labile linker-based calicheamicin<br />
pH<br />
set…<br />
residues serve essential<br />
Cysteine<br />
in protein structure and<br />
roles<br />
due to their highly<br />
function<br />
thiol side chains that<br />
reactive<br />
inter or intra molecular di-<br />
form<br />
bonds to enable correct<br />
sulfide<br />
ADCs<br />
W W W . C R E A T I V E - B I O L A B S . C O M<br />
c y s t e i n e c o n j u g a t i o n<br />
protein folding.<br />
d i s u l f i d e l i n k e r<br />
linkers are a family of chemically<br />
Disulfide<br />
linkers that non-selevtively release<br />
cleavable<br />
payload drug upon the exposure to an<br />
the<br />
chemical environment, which in this<br />
altered<br />
is the higher reducing potential within<br />
case,<br />
tumor cells compared to that of the<br />
the<br />
criculating plasma.<br />
w w w . c r e a t i v e - b i o l a b s . c o m / a d c
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