et. al. J. Am. Chem. Soc.
et. al. J. Am. Chem. Soc.
et. al. J. Am. Chem. Soc.
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HO<br />
MeO<br />
OH<br />
O<br />
Me<br />
Me<br />
O<br />
Me<br />
Me<br />
Me OH Me<br />
MeO HO<br />
Me<br />
O<br />
O<br />
OH<br />
O<br />
OH<br />
H<br />
Apoptolidin<br />
O O<br />
Me<br />
HO<br />
OMe<br />
O<br />
Me<br />
Me<br />
O<br />
Me<br />
• Formula : C 58 H 96 O 21<br />
• Molecular Weight : 1129.37<br />
• Induced apoptotic cell death in rat glia cells transformed with a oncogene<br />
OH<br />
OMe<br />
(IC 50 = 11 ng/mL) but not in norm<strong>al</strong> cells (IC 50 > 100 mg/mL)<br />
• Isolated from Nocardiopsis sp.<br />
• Stereochemistry was d<strong>et</strong>ermined by<br />
NMR and degradation studies.<br />
• The top 0.1% most selective agents tested in the NCI's 60 human cancer cell<br />
line panel out of the more than 37,000 compounds an<strong>al</strong>yzed to date
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