Honours Project Book - Faculty of Health Sciences - University of ...
Honours Project Book - Faculty of Health Sciences - University of ...
Honours Project Book - Faculty of Health Sciences - University of ...
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Nutritional Immunology<br />
Contact Persons<br />
Imme Penttila<br />
Phone : 8161 7072<br />
irmeli.penttila@adelaide.edu.au<br />
Beverly Muhlhausler<br />
Phone: 8313 0848<br />
beverly.muhlhausler@adelaide.edu.au<br />
Supervisors<br />
A/Pr<strong>of</strong> Imme Penttila<br />
Dr Beverly Mulhausler<br />
Pr<strong>of</strong> Robert Gibson<br />
Location: Women’s and Children’s <strong>Health</strong> Research<br />
Institute<br />
Biomarkers such as cytokines and eicosanoids are potent mediators that can act together and play a critical role in<br />
inflammation and other disease states. In some clinical trials, blood sample analysis is an integral part <strong>of</strong> assessing<br />
physiological and immune function in participants. This blood collection and analysis involves using volumes <strong>of</strong><br />
blood, which are not possible to obtain from new born infants. New born infants however undergo screening<br />
programs based on analysis <strong>of</strong> a single sample <strong>of</strong> capillary blood collected by heel prick between 3 and 14 days <strong>of</strong><br />
age. In this project we will aim to develop and validate a method <strong>of</strong> assessing cytokines and other markers in dried<br />
blood spot samples.<br />
In summary, this project will ideally suit an enthusiastic student who is interested in learning more more about<br />
nutritional intervention and the development <strong>of</strong> immuno-based assays for detecting biomarkers from associated<br />
clinical trials.<br />
PROJECT: (Basic) Measurement <strong>of</strong> immune markers in<br />
dried blood spots by immunoassay.<br />
WCHRI Scholarship available:<br />
Contact: 81617443<br />
Website http://www.wchri.com.au/<br />
<strong>Project</strong> Background<br />
Biomarkers such as cytokines and eicosanoids are<br />
potent mediators that can act together and play a<br />
critical role in inflammation and other disease states.<br />
In some clinical trials, blood sample analysis is an<br />
integral part <strong>of</strong> assessing physiological and immune<br />
function in participants. This blood collection and<br />
analysis involves using volumes <strong>of</strong> blood, which are<br />
not possible to obtain from new born infants. New<br />
born infants however undergo screening programs<br />
based on analysis <strong>of</strong> a single sample <strong>of</strong> capillary<br />
blood collected by heel prick between 3 and 14<br />
days <strong>of</strong> age. In this project we will aim to develop<br />
and validate a method <strong>of</strong> assessing cytokines and<br />
other markers in dried blood spot samples.<br />
In summary, this project will ideally suit an enthusiastic<br />
student who is interested in learning more about<br />
nutritional intervention and the development <strong>of</strong><br />
immuno-based assays for detecting biomarkers from<br />
associated clinical trials.<br />
Reference<br />
Skogstrand et.al. Effects <strong>of</strong> blood sample handling<br />
procedure on measurable inflammatory markers in<br />
plasma, serum, and dried blood spot samples. J<br />
Immunol Methods 336(2008) 78-84<br />
64 |
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