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DESCRIPTION ADDITIONAL INFORMATION REVIEWS (0)<br />

<strong>Temonat</strong> <strong>250</strong> <strong>mg</strong><br />

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(Temozolomide)<br />

Uses<br />

<strong>Temonat</strong> <strong>250</strong> <strong>mg</strong> capsule is used in adults and in children above 3 years of age to treat certain specific types of<br />

brain tumor such as glioblastoma multiforme (malignant grade IV brain tumor) or anaplastic astrocytoma (grade III<br />

brain tumor). It is usually used together with radiotherapy or other medications and is generally given after other<br />

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How it works<br />

<strong>Temonat</strong> <strong>250</strong> <strong>mg</strong> capsule is an antitumor drug and belongs to a class of medications called alkylating agents. It<br />

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Common side effects<br />

Nausea, Pale colored skin, Altered vision, Memory impairment, Confusion, Constipation, Diarrhoea, Dizziness,<br />

Fainting, Fever, Hair loss, Headache, Insomnia, Loss of appetite, Balance disorder (loss of balance), Coordination<br />

impaired, Sore mouth, Sore throat, Vomiting, Weakness<br />

Interaction for <strong>Temonat</strong><br />

Food : It is better to take this medicine empty stomach (1 hour before food or 2 hours after food).<br />

Alcohol : Interaction with alcohol is unknown. Please consult your doctor.<br />

Pregnancy : It is unsafe to use during pregnancy. Human and animal studies have shown adverse effects on the<br />

foetus. The potential benefits may warrant the use in pregnant women despite potential risks. Please consult your<br />

doctor.<br />

Lactation : It is probably unsafe to use during breastfeeding. Please consult your doctor.<br />

Expert advice for <strong>Temonat</strong><br />

• Swallow full tablets on an empty stomach, one hour before your meal.<br />

• Avoid being near people who are sick or have infections. Consult your doctor if you develop symptoms of<br />

opportunistic infections (such as Pneumocystis jirovecii pneumonia) and reactivation of infections (such as<br />

hepatitis B virus) Using temozolomide may increase your risk of developing certain types of bone marrow cancer.<br />

Be aware about your specific risk.<br />

• You may be given medication to prevent nausea or other side effects while you are receiving temozolomide.<br />

• Your blood will be tested frequently during treatment to monitor the side effects of temozolomide on your blood<br />

cells as you may have a small risk of other changes in blood cells, including leukemia.<br />

• Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while<br />

shaving or brushing your teeth.<br />

• Do not drink alcohol while taking temozolomide.<br />

• Do not drive or operate machinery while using temozolomide as it may make you tired or sleepy.<br />

• Both male and female patients should take effective contraceptive precautions during and after 6 months of<br />

treatment. Male patients should seek advice on conservation of sperm prior to treatment as temozolomide treatment<br />

may cause infertility.<br />

Frequently asked questions for <strong>Temonat</strong><br />

Temozolomide<br />

Q. What is temozolomide used for/ what does temozolomide treat/ Is temozolomide chemotherapy/ is<br />

temozolomide cytotoxic/ is temozolomide a radiosensitizer?<br />

Temozolomide is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug. It is used to treat specific types<br />

of brain tumor. It is a radiosensitizer.<br />

Q. Is temozolomide effective/ does temozolomide work?<br />

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Temozolomide is effective and works for patients if taken at re<strong>com</strong>mended dosage and duration as re<strong>com</strong>mended<br />

by the doctor.<br />

Q. How is temozolomide given/administered/ metabolized/ how long does temozolomide stay in the body?<br />

Temozolomide is given as a capsule and is taken by mouth. It should be administered in the fasting state, at least<br />

one hour before meal. It is rapidly metabolized at physiologic pH to the active monomethyl triazenoimidazole<br />

carboxamide (MTIC). The half-life (t1/2) in plasma is approximately 1.8 hours.<br />

Q. How does temozolomide cross the blood-brain barrier?<br />

Temozolomide because of its small size and lipophilic properties is able to cross the blood-brain barrier rapidly and<br />

is present in the cerebrospinal fluid.<br />

Q. Does temozolomide cause hair loss?<br />

Hair loss is a side effect of using temozolomide. Always follow doctor’s advice regarding its use.<br />

Q. Is temozolomide FDA approved?<br />

Temozolomide is a FDA approved drug.<br />

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Disclaimer<br />

We provide only general information about medications which does not cover all directions, possible drug<br />

integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any<br />

specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of<br />

the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any<br />

direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for<br />

consequences of self-treatment.<br />

Equivalent Brand<br />

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