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<strong>Antibody</strong> <strong>Drug</strong> <strong>Conjugates</strong> - A Groundbreaking Solution to Cancer<br />
In pursuit of more targeted therapies and clinically effective drugs, pharmaceutical companies<br />
are increasing their research and development activities in biologics. Although a majority of this<br />
work is focused on monoclonal antibodies (mAbs) and recombinant proteins, progress is being<br />
made in specialized drugs. <strong>Antibody</strong> drug conjugates (ADCs) are a new class of drugs that is<br />
gaining attention from both large and small pharmaceutical companies as they offer promise in<br />
cancer therapeutics. They consist of an mAb - an antibody that is specific to the target associated<br />
antigen, a cytotoxic drug - designed to kill target cancer cells, and a linker - that attaches the<br />
cytotoxic agent to the antibody. Thus, antibody drug conjugates combine the targeting ability of<br />
monoclonal antibody and the target specific cell killing ability of cytotoxic drugs.<br />
The market for antibody drug conjugates is witnessing a fast growth, which is supported by the<br />
advancement in medical technology, the rise in the occurrence of cancer cases worldwide,<br />
growing ageing population, and the growing obese population. Furthermore, the increased<br />
research activities on antibody therapies, advanced drug discoveries and oncology diseases as<br />
well as the growing collaboration between research institutes are propelling the growth of the<br />
industry. Nonetheless, the high cost of the procedures and the lack of fund pose a threat to the<br />
growth of the ADC market. According to a report published by Allied Market Research, the<br />
antibody drug conjugates market is expected to reach $3,198 million by 2023, registering a CAGR<br />
of 12.9% from 2017 to 2023.<br />
Companies within the space are coming up with superior technologies to develop more effective<br />
and efficient antibody drug conjugates. For instance, ADC Therapeutics, a developer of<br />
proprietary PBD-based antibody drug conjugates, recently announced that it would deliver its<br />
presentations regarding strong preclinical data for its two new investigational programs ADCT-<br />
601 targeting AXL and ADCT-701 targeting DLK-1 at the American Association for Cancer Research<br />
(AACR) Annual Meeting. Daiichi Sankyo, a global pharmaceutical company announced that its<br />
HER2-targeting antibody drug conjugate (ADC) received SAKIGAKE Designation for the treatment<br />
of gastric cancer by the Japan Ministry of Health, Labor and Welfare (MHLW). Synaffix, a<br />
Netherlands-based biotech company announced the launch of a new platform of highly potent<br />
cytotoxic ADC payloads that integrates into its existing ADC platform.<br />
ADC Therapeutics to Present Two Novel ADCs<br />
In April 2018, ADC Therapeutics announced its presentation regarding strong preclinical data for<br />
its two new investigational programs ADCT-601 targeting AXL and ADCT-701 targeting DLK-1 at
the American Association for Cancer Research (AACR) Annual Meeting which takes place from<br />
April 14-18, 2018 in Chicago, USA. Dr. Jay Feingold, Chief Medical Officer and Senior Vice<br />
President of Clinical Development at ADCT said, “Our two new investigational programs show<br />
compelling efficacy and safety in preclinical studies. These results provide an important step to<br />
advance ADCT-601 and ADCT-701 into the clinic and enlarge our pipeline of PBD-based ADCs in<br />
multiple ongoing clinical trials for the treatment of both solid and hematological cancers.”<br />
Highlights of the data to be presented are available on the AACR conference website at<br />
www.aacr.org<br />
Daiichi Sankyo's HER2-Targeting <strong>Antibody</strong> <strong>Drug</strong> Conjugate Receives SAKIGAKE Designation for<br />
Gastric Cancer<br />
In March 2018, Daiichi Sankyo announced that DS-8201, an HER2-targeting antibody drug<br />
conjugate (ADC) received SAKIGAKE Designation for the treatment of HER2-positive advanced<br />
gastric or gastroesophageal junction cancer by the Japan Ministry of Health, Labor, and Welfare<br />
(MHLW). The company said that it intends to work closely with the Japan MHLW under the terms<br />
of the SAKIGAKE program to speed up the development of DS-8201 since Japan has one of the<br />
highest cases of gastric cancer worldwide. The SAKIGAKE Designation system fosters R&D in<br />
Japan, propelling early practical application for novel pharmaceutical products, medical devices,<br />
and regenerative medicines. As a designated medicine under the system, DS-8201 has prioritized<br />
consultation, a dedicated review system to support the development and review process, and a<br />
reduced review time.<br />
Synaffix Launches toxSYN, a New Platform of ADC Payloads<br />
Synaffix BV, a biotechnology company announced thgrowinge launch of a new platform of<br />
cytotoxic ADC payloads that integrates into its current ADC platform. With the launch, the<br />
company becomes a provider of technologies needed to quickly translate antibodies into<br />
proprietary ADC products. The new toxSYN platform comprises four highly potent payloads<br />
offering multiple mechanisms of action and a way for commercialization when integrated with<br />
the components of Synaffix’s GlycoConnect and HydraSpace technologies. Validated clinically<br />
with well-known efficacy and safety profiles, the payloads were selected to address the two types<br />
of biologies that exist across ADC targets such as rapidly-dividing cancer cells and quiescent cells.<br />
“We expect this important expansion of our ADC technology to further advance our internal<br />
research and facilitate collaborations with a much broader set of companies,” said Peter van de<br />
Sande, CEO of Synaffix. “By providing these four distinct payloads through our new toxSYN<br />
platform, we can now enable any company with an existing antibody to rapidly establish a highlycompetitive<br />
clinical-stage ADC program for its own development pipeline.”<br />
Read more at: https://www.alliedmarketresearch.com/antibody-drug-caonjugate-market