FM SEPTEMBER 2018 ISSUE - digital edition

ADVERTORIAL
IQWave
Dynamic-ElectroEnhanced
Chemotherapy —D-EECT
THE NEXT GENERATION OF ELECTROCHEMOTHERAPY
IQWave enhances traditional
chemotherapy with tumour-adapted
electric field and more controlled
distribution of it. This improves the
coverage of the electrical currents and
thereby improves the therapeutic effect.
Using the IQWave Probe, the physician
have choice of treating different size
of tumour affected area. This unique
technology makes it possible to treat
tumours that are hard to reach with
traditional electrochemotherapy
treatment - such as oral tumours and
tumours located at the root of the tongue,
among others. Thanks to its integrated
tumour-specific data base, the treating
doctors will be able to exchange data on
treated tumours. IQWave has a laptop
size design for ease of transport and
storage.
Unique treatment benefits
A train of 8 dynamic high voltage pulses
of 5kHz with a duration of 100µsec is
applied on the tumour cell.
The treatment is multi-dimensional,
which means that the pulses will travel
horizontally, vertically and diagonally
during the same treatment cycle, optimally
covering the tumour.
IQWave with only four electrodes
can minimise the risk of untreated
surfaces. Electrodes position can be
arranged to achieve two configurations –
12mm and 8 mm, depending on
size of treatment area.
Outcome of D-EECT
Rearrangement of the membrane
phospholipid bilayer occurs on the applied
area with the formation of hydrophilic
pores allowing the cytotoxic drug enter
into the nucleus and attack DNA.
Reversible effect called vascular lock leads
to capturing cytotoxic drug.
Exposure of tumour cells to the pulses
of electrical fields in itself can cause
apoptosis by electroporation.
In some cases, D-EECT (Dynamic-
ElectroEnhanced Chemotherapy)also
creates immunological effect by activating
the immune-system.
IQWave - Applications
ChemoTech’s IQWave, has treated
several cutaneous and subcutaneous
cancers regardless of tumour histology in
the areas of head and neck, breast, oral and
skin, among others. The focus is primarily
palliative, but the effect of the treatment
can also in some cases be curative.
An interesting article from Dr. Shramana
Banerjee on electrochemotherapy
treatment in breast cancer says
“Electrochemotherapy provides an
alternative treatment for patients that
have irradiated skin and an option
when all other therapies have failed.
One of the most promising aspects of
electrochemotherapy is its unique ability
to selectively kill tumour cells without
harming normal surrounding tissue as is
targeted by the application directly over
the lesions to be treated. Drug resistant
tumour cells in combination with
electrochemotherapy will allow cytotoxic
action potentiated up to 700 folds.
Electrochemotherapy may also be used
in adjunct to other forms of established
treatment such as radiotherapy; although
hypoxia causes radio-resistance,
electrochemotherapy agents have also
radio sensitizing effects that are further
amplified during electrochemotherapy.
This advantage may be utilized in the
development of combined therapeutic
treatment planning.”
Fast and effective treatment
IQWave has a significant advantage
of treating patients on outpatient
basis as the entire treatment including
preparation takes only about
45 minutes, - the patient stay in
hospital is less.
This is a sponsored article. FM editorial holds no responsibility for the information therein.
96 / FUTURE MEDICINE / SEPTEMBER 2018