Anti-cancer screening of herbal drugs using cancer patient cells
Since the 1980s, a total of 174 new anti-cancer compounds have been approved for commercialization, of which 93 (53%) were natural products, or derived directly from plants. One of the most famous anti-cancer drugs, paclitaxel, used for the treatment of breast cancer, was isolated from the bark of Taxus Brevifolia. There is tremendous opportunity to systematically investigate promising plants and extracts for their anti-cancer activity and validate it rigorously in drug discovery campaigns. Even traditional plant-based medicines that have been in use for years need more data to claim anti-cancer activity. We provide a platform to pharma and biotech companies for screening their plant extracts and compounds directly on patient tumor-derived primary cancer cells (PDCs), in 2D and 3D assays, to confirm and compare their activity prior to testing in xenograft and PDX models.
Since the 1980s, a total of 174 new anti-cancer compounds have been approved for commercialization, of which 93 (53%) were natural products, or derived directly from plants. One of the most famous anti-cancer drugs, paclitaxel, used for the treatment of breast cancer, was isolated from the bark of Taxus Brevifolia. There is tremendous opportunity to systematically investigate promising plants and extracts for their anti-cancer activity and validate it rigorously in drug discovery campaigns. Even traditional plant-based medicines that have been in use for years need more data to claim anti-cancer activity. We provide a platform to pharma and biotech companies for screening their plant extracts and compounds directly on patient tumor-derived primary cancer cells (PDCs), in 2D and 3D assays, to confirm and compare their activity prior to testing in xenograft and PDX models.
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About Us
16
11 July 2020
Sapien Biosciences
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