Anti-cancer screening of herbal drugs using cancer patient cells
Since the 1980s, a total of 174 new anti-cancer compounds have been approved for commercialization, of which 93 (53%) were natural products, or derived directly from plants. One of the most famous anti-cancer drugs, paclitaxel, used for the treatment of breast cancer, was isolated from the bark of Taxus Brevifolia. There is tremendous opportunity to systematically investigate promising plants and extracts for their anti-cancer activity and validate it rigorously in drug discovery campaigns. Even traditional plant-based medicines that have been in use for years need more data to claim anti-cancer activity. We provide a platform to pharma and biotech companies for screening their plant extracts and compounds directly on patient tumor-derived primary cancer cells (PDCs), in 2D and 3D assays, to confirm and compare their activity prior to testing in xenograft and PDX models.
Since the 1980s, a total of 174 new anti-cancer compounds have been approved for commercialization, of which 93 (53%) were natural products, or derived directly from plants. One of the most famous anti-cancer drugs, paclitaxel, used for the treatment of breast cancer, was isolated from the bark of Taxus Brevifolia. There is tremendous opportunity to systematically investigate promising plants and extracts for their anti-cancer activity and validate it rigorously in drug discovery campaigns. Even traditional plant-based medicines that have been in use for years need more data to claim anti-cancer activity. We provide a platform to pharma and biotech companies for screening their plant extracts and compounds directly on patient tumor-derived primary cancer cells (PDCs), in 2D and 3D assays, to confirm and compare their activity prior to testing in xenograft and PDX models.
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Screening in MDA-MB 231 TNBC Cell Line, part of NCI-60 Panel
Dose response study of two natural extracts
We also perform screening in cell lines
Here, the MDA-MB 231 cell line,
established from pleural effusion of a
Caucasian female with a metastatic
mammary adenocarcinoma, was used
Standard of Care Drugs for Breast Cancer (SOC)
Observation: Both the extracts showed better anti-cancer activity in TNBC patient-derived cells than in cell line
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11 July 2020
Sapien Biosciences
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