Phospholipids

Phospholipids
• Phospholipids are a type of lipids that are a major component of cell
membranes. They can form lipid bilayers for their amphiphilic
characteristic. The structure of a phospholipid molecule typically
consists of two hydrophobic fatty acid "tails" and a hydrophilic
"head" consisting of a phosphate group. These two components are
joined together by a glycerol molecule. The phosphate group can be
modified with simple organic molecules such as choline. The first
phospholipid discovered in 1847 as such in biological tissues was
lecithin, or phosphatidylcholine, in the egg yolk of chickens by the
French chemist Theodore Nicolas Gobley. Biological membranes in
eukaryotes also contain another kind of lipid, sterol, interspersed
among the phospholipids and together they offer membrane fluidity
and mechanical strength.

• Phospholipids Analysis Service
• Phospholipids Analysis Service
• Phospholipids are a type of lipids that are a major component of cell membranes. They can form lipid bilayers for their amphiphilic characteristic. The structure of a
phospholipid molecule typically consists of two hydrophobic fatty acid "tails" and a hydrophilic "head" consisting of a phosphate group. These two components are joined
together by a glycerol molecule. The phosphate group can be modified with simple organic molecules such as choline. The first phospholipid discovered in 1847 as such in
biological tissues was lecithin, or phosphatidylcholine, in the egg yolk of chickens by the French chemist Theodore Nicolas Gobley. Biological membranes in eukaryotes also
contain another kind of lipid, sterol, interspersed among the phospholipids and together they offer membrane fluidity and mechanical strength.
• Phospholipid synthesis happens in the cytosole adjacent to ER membrane which is studded with proteins that act in synthesis and allocation (flippase and floppase). Ultimatelya
vesicle will bud off from the ER containing phospholipids destined for the cytoplasmic cellular membrane on its exterior leaflet and phospholipids destined for the exoplasmic
cellular membrane on its inner leaflet.
• Phospholipids have been widely applied to prepare ethosomal, liposomal and other nanoformulations of topical, oral and parenteral drugs for differing reasons like improved
bio-availability, increased penetration andreduced toxicity. Liposomes often consist of phosphatidylcholine-enriched phospholipids and may contain mixed phospholipid chains
with surfactantproperties. The ethosomal formulation of ketoconazole using phospholipids is a promising option for transdermal delivery in fungal infections.
• Currently, a reliable and reproducible method using highly sensitive LC-MS/MS platform for the identification and quantification of diverse phospholipid species in different
sample types has been established by the scientists at Creative Proteomics, which can satisfy the needs of academic and industrial study in your lab.