LIBRO DE OBSEQUIO SORPRESA 1 BREAST CANCER

26
Histological Diagnosis of Implant-Associated Pathologies
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Fig. 23 Large aggregates of corrosion products generated from a metallic blade–plate/metallic screws fixation
device (H&E, ×400)
globin due to hemorrhage secondary to mechanical complications (e.g., patellar malfunction
and instability, dislocation(s), periprosthetic fracture). They are easily detectable with
the PBR stain, which is blue in their presence (. Fig. 24a and b). The stain is also useful
to differentiate between fine globular hemosiderin particles and globular aggregates of
nano-size particles of corrosion products or fine ceramic particulate debris that can have
a similar color on H&E stain.
a
b
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Fig. 24 Hemosiderin particles. Macrophagic infiltrate containing hemosiderin particle with iron content.
Deposits range in shape from fine to coarse granules, gold brown in a (H&E, ×400) and blue in b (Prussian blue,
×400)