LIBRO DE OBSEQUIO SORPRESA 1 BREAST CANCER

30
Histological Diagnosis of Implant-Associated Pathologies
. . Fig. 29 Polymethyl methacrylate orthopedic cement. Florid macrophagic infiltrate containing numerous
particles of zirconium dioxide in a case of unicompartmental knee implant failure secondary to third-body wear
(H&E, ×400)
3 Clinical Approach to Synovial-Like Interface Membranes
Wear particles are one of the main causes of prosthesis loosening. SLIM allows us to shed
light on the processes occurring at the level of the interaction between the particle and the
soft tissue on the implant interface. Information received via microscopy and some kinds
of histological analyses can be compared with radiological findings and intraoperative
tissue conditions.
The influence of implant positioning and neck-on-liner impingement on prosthesis
loosening could be clarified by examining the SLIM. There are numerous data concerning
the influence of implant component malposition on the survival rate of implants, but without
an exact explanation of how it works. Controlling the pathogenetic triggers of osteolysis
can be used for the prophylaxis of implant loosening.
The optimum size of the femoral ball head for hip implants is not defined. There are
several pros and cons concerning heads of greater diameter and smaller ones. However,
there is a lack of information in the literature about the association between the head
diameter and bone osteolysis.
Research on SLIM can offer additional information on the pattern of bearing wear and
the comparative performance of various types of materials. Such information can help
manufacturers improve materials that are currently available on the market leading to
better clinical outcomes for partial and total joint arthroplasties.