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Elegant Defense, An: The Extraordinary New Science of the Immune System: A
Tale in Four Lives
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Hardcover: 448 pages Publisher: William Morrow; 1 edition (March 12, 2019) Language: English ISBN-10: 0062698532
ISBN-13: 978-0062698537 Product Dimensions: 6 x 1.4 x 9 inches Shipping Weight: 1.6 pounds (View shipping rates and
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Book Description
“A deeply reported and entertainingly written exploration of the human immune system and how it works.” —USA Today
National Bestseller * The essential book to read to understand your immune system during the coronavirus (COVID-19)
pandemic The Pulitzer Prize–winning New York Times journalist "explicates for the lay reader the intricate biology of our
immune system" (Jerome Groopman, MD, New York Review of Books) New York Times science reporter Matt
Richtel's An Elegant Defense illuminates the human immune system as never before, uniquely entwining intimate patient
stories with science’s centuries-long quest to unlock the mysteries of sickness and health. The immune system is our
body’s essential defense network, a guardian vigilantly fighting viruses and illness, healing wounds, maintaining order and
balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body,
linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost
infinite array of threats. For all its astonishing complexity, however, the immune system can be easily compromised by

fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene.
Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to
epidemic levels of autoimmune disorders. Richtel effortlessly guides readers on a scientific detective tale winding from the
Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are
revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The
foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and
autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these
powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but
always on a razor’s edge that can throw this remarkable system out of balance. Drawing on his groundbreaking reporting
for the New York Times and based on extensive new interviews with dozens of world-renowned scientists (including Dr.
Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases), Matt Richtel has produced a
landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly
brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant
defense.”