Neopl-L1-15

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Dysplasia• in mature tissues, it refers to disordered growth of cells.• loss of cell uniformity & architectural disorganization.• primarily in epithelium; early indicator of neoplastic transformation.• characterized by cellular atypia: pleomorphism. nuclei often hyperchromatic,enlarged (↑ N/C ratio) & largenucleoli. more mitotic figures; inabnormal locations. tissue architecture is oftendisorganized.Adaptive changes in epitheliumPathologic Basis of Veterinary Disease (2006), 4 th ed., Mosby-Elsevier
CRobbins and Cotran Pathologic Basis of Disease (2010), 8 th ed., Elsevier, Inc.SBNormal squamous epithelium. Stratum basale (B), stratumspinosum /lucidum (S), stratum corneum (C).Dysplastic squamous epithelium. There is no differentiation(maturation), so most cells look like basal cells.Dysplastic squamousepithelium. Dysplasticcell show large(karyomegaly)hyperchromatic nuclei(arrows) .
Page 1 and 2: General Pathology VPM 152Disorders
Page 3 and 4: Complementary textbooks:• Kumar,
Page 5 and 6: NORMAL TISSUE GROWTH AND CELL PROLI
Page 7 and 8: Stem Cellsb) Primordial Germ Cells
Page 9 and 10: Adult Stem CellsBStem cell niches i
Page 11 and 12: Aplasia• failure of an organ / ti
Page 13 and 14: Unilateral hypoplasia (right sided)
Page 15 and 16: Causes of Developmental Anomalies
Page 17 and 18: Hyperplasiab) Mechanisms / Biochemi
Page 19 and 20: TGoiter, thyroid gland, goat fetus.
Page 21 and 22: Pathologic Basis of Veterinary Dise
Page 23 and 24: Nodular hyperplasia, liver, dog. Si
Page 25 and 26: Nodular adrenal cortical hyperplasi
Page 27: Metaplasia• one adult cell type i
Page 31 and 32: Joseph Merrick photographed in 1889

Neopl-L1-15

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