Migraine Mystery Solved_

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10/11/2020 Migraine Mystery Solved?means that taking L-tryptophan will result in producingless serotonin than after supplementing with 5-HTP. BothL-Tryptophan and 5-HTP must cross the blood-brainbarrier to make serotonin in the brain. However, unlike L-Tryptophan 5-HTP doesn’t have to compete with otheramino acids to cross the blood-brain barrier. As a result 5-HTP is much more e ective in getting into brain than it isin case of L-tryptophan. For this reason 5-HTP is regardedas signi cantly more e ective form of tryptophan inboosting brain serotonin levels. Human body uses L-tryptophan to produce a number of compounds includingNiacin (Vitamin B3), but 5-HTP is only used to produceserotonin and melatonin (from serotonin). Your body canconvert L-Tryptophan and 5-HTP to serotonin in the liverand also in the brain. When Part of L-tryptophan can beconverted to serotonin in the liver and this serotonin can’tbe used by the brain to improve mood or preventmigraine.While supplementing with L-tryptophan and 5-HTP it isalso very important to make sure that the rst is takenwith vitamin B3 and the second with vitamin B6.Tryptophan is crucial in boosting serotonin levels becauseserotonin is made in the body from tryptophan.Tryptophan is rst converted in the liver into 5HTP (5-Hydroxy L-Tryptophan) by the enzyme tryptophanhydroxylase with the help of vitamin B3 (niacin). Theproblem, however, is that when the liver attempts toconvert tryptophan to 5HTP in the absence of adequatelevels of vitamin B3, it will use tryptophan to synthetize it,and it uses 60mg of tryptophan to produce 1mg of niacin,thus leading to tryptophan and serotonin de ciency! Thatis why if L-tryptophan supplements are taken instead of 5-HTP it should be used with B3. On the other hand, when 5-HTP gets into the liver another enzyme (decarboxylase)converts it to 5HT, but it can do it e ectively only with thehelp of vitamin B6 (pyridoxine). Unfortunately, when bodyis de cient in this vitamin, liver will convert 5HTP to sometoxic metabolites! For this reason 5-HTP, whiche ectiveness in boosting serotonin levels is higher thanhttps://www.healthaid.co.uk/healthaid-blog/MIGRAINE-MYSTERY-SOLVED 6/13
10/11/2020 Migraine Mystery Solved?that of L-tryptophan, should be supplemented withpyridoxine (vitamin B6).VITAMIN B2 (RIBOFLAVIN)Apart from 5-HTP (Tryptophan) also vitamin B2 (ribo avin)supplementation seems to be bene cial in coping withmigraine headaches. In mentioned below studies usuallyabout 300-400mg of a daily dose of ribo avin was used:“A 2016 review on the clinical evidence behind Ribo avinfor Migraine concluded that daily doses of B2 mayimprove mitochondrial function, thereby preventingattacks and reducing the need for treatment.”“A 2004 study found that patients who took Ribo avinexperienced signi cantly fewer headaches and used fewermigraine pain killers or could completely avoidmedications.”“A 2016 review on the clinical evidence behind Ribo avinfor Migraine concluded that daily doses of B2 mayimprove mitochondrial function, thereby preventingattacks and reducing the need for treatment.”“A 2015 trial of 55 migraine patients on vitamin B2 showeddecreased migraine ‘attack frequency’ and ‘headachedays’.”“1998 study of 80 patients with migraine found that thosein the Ribo avin group experienced 50% fewer migrainesand reduced severity of pain than those in the placebogroup (15% reduction).”“Since in case of migraine headaches Vitamin B2 may beable to achieve similar results to prescription alternativeswith much fewer problems, ribo avin can be consideredas safe and more natural alternative to meds.”In addition, Vitamin B2 is also needed to make serotonin,which de ciency is regarded as the key trigger of migrainehttps://www.healthaid.co.uk/healthaid-blog/MIGRAINE-MYSTERY-SOLVED 7/13
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