Fat killer--Cetilistat VS Orlistat

Wuhan wingroup Pharmaceutical Co.,Ltd.,

http://www.whwingroup.com/

Fat killer--Cetilistat VS Orlistat

1. What’s Cetilistat?

Cetilistat (CAS no.282526-98-1) also known as ATL-962, ATL 962 or Citilistat

is a drug indicated for the treatment of obesity. It is used along a low calorie,

low-fat diet, and proper exercise to aid in weight loss.

The cetilistat anti-obesity drug is sold under different brand names including

Cetislim, Kilfat, Oblean, and Checkwt.

Cetilistat is a benzoxazine, gastrointestinal lipase inhibitor that primarily works

by preventing the digestion and absorption of dietary fats.

2. How Cetilistat treats obesity?

Obesity is one of the most prevalent public health problems in the world today.

It is a complex, chronic as well as a multifactor disorder characterized by the

accumulation of excess fat/adipose tissue.

Obesity is associated with health disorders such as type 2 diabetes,

hypertension, hyperlipidemia, high cholesterol, certain cancers, and some

cardiovascular disease such as stroke and coronary heart disorder.

Obesity in many countries has reached epidemic proportions and hence a

worldwide health concern.

Research shows that a sustained weight loss of 5 to 10 % of your initial body

weight can significantly reduce obesity-related metabolic disorders.

Cetilistat is considered an anti-obesity agent. Anti-obesity agents usually

increase energy expenditure thus weight loss through both neural and

metabolic regulation.

Cetilistat is a gastrointestinal pancreatic lipase inhibitor that is an effective

anti-obesity agent in human studies.

1

Sale11@whwingroup.com



Cetilistat works by blocking the digestion and absorption of fat within the food

you consume. When the fat is not digested it is excreted in feces during bowel

movements. It accomplishes this by inhibiting the enzyme lipases responsible

for breaking down triglycerides (a fat/lipid in the body) in the intestines.

The cetilistat effects are therefore exhibited in the gastrointestinal tract. It

hence means that cetilistat is distinct from other anti-obesity agents that

influence your brain to reduce appetite because it works periphery.

When the digestion and absorption of dietary fats are inhibited, deposition of

fats is limited thus low energy expenditure that results in weight loss.

Although, Cetilistat will help you lose weight it is upon you to maintain a low-fat

nutritious diet accompanied by exercise for successful obesity management.

3. Cetilistat VS Orlistat

Both cetilistat and orlistat are prescription drugs used for the treatment of

obesity. They exhibit a similar mode of action through which they achieve

weight loss.

Cetilistat and orlistat are gastrointestinal lipases inhibitor that prevents or

reduces the digestion and absorption of dietary fats. The lipases are

responsible for the breakdown of triglycerides in the intestines. The unchanged

fats are instead excreted through bowel movements in human feces. This

activity ensures that the fats are not absorbed in the body leading to weight

loss.

Significant weight reduction has been reported in both cetilistat and orlistat.

The success of cetilistat vs orlistat depends on your lifestyle as they require

you to stick to a low-calorie nutritious diet coupled with regular exercise.

Cetilistat as well as orlistat exhibit enhanced glycemic control as evidenced by

a significant reduction in plasma glycosylated hemoglobin. They also reduce

the risk of obesity-related disorders such as heart diseases, high blood

pressure, high cholesterol levels, and type 2 diabetes.

The most common side effects associated with cetilistat and orlistat are

gastrointestinal effects usually due to the unchanged fats. However, when you

compare cetilistat vs orlistat in terms of side effects, more side effects are

2




associated with orlistat than in cetilistat. In addition, the severity of the effects

is more pronounced with orlistat than with cetilistat.

When comparing the tolerability of cetilistat vs orlistat, cetilistat has been

reported to be well tolerated than orlistat.

A 12 weeks’ study involving obese patients with type 2 diabetes was

conducted to assess weight loss, reduction in glycosylated hemoglobin, and

tolerability of cetilistat compared to orlistat. The treatment was combined with a

low to moderate fat diet and diabetes mellitus managed using metformin.

The study found that both cetilistat and orlistat significantly reduced weight as

well as improved glycemic control. The drugs also reduced the risk of

cardiovascular disorders by reducing waist circumference which is an indicator

of heart disease.

In this study, the side effects observed were gastrointestinal effects which

were more with orlistat, and also the severity of orlistat-related effects was

found to be higher than that of cetilistat. The differences in the effects of

cetilistat vs orlistat may be attributed to their structural and chemical

differences.

Withdrawals from the study were due to side effects and were more with

orlistat than with cetilistat. Furthermore, cetilistat was more tolerated than

orlistat.

4. Who can use Cetilistat?

You may consider taking Cetilistat (282526-98-1) if you need to lose weight.

However, like with any other drug, take the necessary precautions while taking

this medication.

Cetilistat is recommended for persons with a body mass index (BMI) that is

higher than 27. It is also advisable to take cetilistat if your BMI is higher than 27

and you suffer from conditions associated with obesity such as diabetes and

hypertension. BMI is an indicator of body fat calculated by dividing your weight

in kilograms by the square of height in meters.

3




If you chose to take cetilistat, be sure to take the recommended cetilistat

dosage with your meals. The prescribed cetilistat dosage is best taken with

meals, during or up to one hour after your meals.

The cetilistat drug occurs in capsules or tablet form for oral administration with

a glass of water. You may also find cetilistat powder. The right cetilistat

dosage and duration of treatment will be determined by your healthcare

provider based on the condition and initial response to the medication.

Cetilistat weight loss benefits are however not indicated for children, hence

you should not give this to children. This is especially with children in puberty

as cetilistat might influence their growth more so with height.

Cetilistat is considered unsafe for pregnant mothers or women trying to

conceive. It can pose a health risk to the unborn child.

Breastfeeding mothers are also advised to avoid cetilistat as it could pass

through to the child.

Your doctor may advise you to take or otherwise avoid cetilistat due to other

prevailing health conditions such as hypersensitivity, cholestasis (liver

disease), and chronic malabsorption syndrome.

5. Cetilistat side effects

Cetilistat powder is considered safe but if you exceed the recommended

cetilistat dosage or fail to follow instructions you experience some cetilistat

side effects. These side effects may occur at the beginning but are mild and

should go away with continued use of the drug. If they do not go away, you

should contact your doctor.

The most common cetilistat side effects are;

Gas with discharge

Nasal congestion

Diarrhea

Headaches

Urgent and frequent bowel movements that might be hard to control

Oily spotting

Oily or fatty stools

4




Some rare but more serious cetilistat side effects might also occur. You should

consult your doctor immediately when you notice the following adverse effects;

Jaundice (yellowing of eyes or the entire body)

Dark urine

Loss of appetite

Unusual fatigue

Severe stomach pain

Difficulty swallowing or breathing.

6. Cetilistat benefits

Cetilistat weight loss benefit in obesity management is the main use it is known

for. There are however other cetilistat benefits that make it distinct and stand

out among other weight loss drugs.

Below are some cetilistat benefits;

Help you maintain a healthy lifestyle through weight loss

Cetilistat is one of the great weight-loss drugs as well as an anti-obesity agent.

In your normal life gaining excessive weight leads to an increase in size and

body fat often referred to as being overweight or obese. The two conditions are

associated with health issues such as type 2 diabetes mellitus, heart disease

like stroke, high blood pressure, and certain cancers like colon and breast

cancers.

The distinction between overweight and obese individuals is the body mass

index (BMI). A person is considered to be overweight when the BMI is greater

than or equal to 25 while a person with obesity has a BMI greater than or equal

to 30.

Taking cetilistat will help your body to reduce the accumulation of fats thus

maintaining a healthy BMI and consequently a healthy lifestyle. This is so

because it lowers the chances of the life-threatening conditions associated

with obesity.

Helps in weight loss and reduction of glycosylated hemoglobin

in obese diabetic patients

5




Diabetes and specifically type 2 diabetes also called diabetes mellitus is a

common disorder in obese patients. Type 2 diabetes occurs when the body

cells resist the proper effect of insulin, which is to direct the blood glucose into

the cells. This leads to glucose accumulation in the blood. obesity is known to

greatly increase the occurrence of type 2 diabetes.

Glycosylated hemoglobin (hemoglobin to which glucose binds) is a measure of

long-term diabetes mellitus control. The level of glycosylated hemoglobin

(HbA1c) shows the average blood glucose over the past three months. The

normal glycosylated hemoglobin level is 7 % but most people with diabetes

can only achieve 9 %.

In a 12-week, randomized, clinical study with a placebo control, obese patients

with type 2 diabetes were given cetilistat (40, 80, or 120mg three times daily).

They were also to stick to a hypocaloric diet. Cetilistat was found to

significantly reduce weight as well as reduce glycosylated hemoglobin (HbA1c).

It was also noted that cetilistat was well tolerated.

Cetilistat is well tolerated

Apart from its effectiveness in reducing weight and managing obesity, there is

more to it. Cetilistat is well tolerated in the body with mild to moderate side

effects which are manageable and may disappear with continued cetilistat use.

Although most of us go for effectiveness in medication, it also good to look for

a drug that is tolerable in your body.

In phase 2 clinical study was conducted for 12 weeks using both cetilistat and

the commonly available orlistat. The two weight-loss drugs were found to be

effective in reducing weight, reducing the glycosylated hemoglobin as well as

reducing the waist circumference. Also, cetilisat was found to well-tolerated

than orlistat, with fewer and less severe side effects associated with cetilistat.

Helps you achieve your goals within a short time

Weight loss is a short-term goal that can be achieved through a change of diet

and accompanied by regular exercise. However, maintaining a healthy weight

is a long-term goal.

Your doctor may recommend a prescription weight loss drug when a healthy

lifestyle (diet and exercise) does not achieve the intended weight loss.

Cetilistat is one of the medications that can be used along with a low-fat diet

6




and regular exercise. Unlike other anti-obesity drugs that take a long time to

achieve significant weight loss, cetilistat takes about 12 weeks to provide the

desired weight.

May help lower your cholesterol level

Cholesterol refers to a waxy substance. It is required by your body to build

cells however, too much may cause issues in the body.

Cholesterol is made by the liver while some come from the foods you consume

such as meat, poultry, and full-fat dairy products. There are 2 types of

cholesterol. Low-density lipoprotein (LDL) cholesterol or the “bad” cholesterol

and high-density lipoprotein or the “good” cholesterol. The LDL contributes to

fatty build-up in arteries hence increase the risk of heart diseases such as

stroke and heart attack.

Being obese increases your risk of high cholesterol levels. Obesity increases

the amount of LDL cholesterol by altering your body’s response to the fats you

consume. The inflammation caused by obesity also decreases your body’s

response to changes in dietary fat intake. In addition, insulin resistance is also

common in patients with obesity. This also affects the normal process of fats in

your body.

Cetilistat can reduce total cholesterol as well as LDL cholesterol.

In a study involving rats, cetilistat administered orally was found to ameliorate

obesity and total cholesterol.

Reduces the risk of cardiovascular disease

Cardiovascular disease is a collective word referring to disorders that affect the

heart or blood vessels. Cardiovascular disease includes coronary artery

diseases such as heart attack and angina, stroke, heart failure, and rheumatic

heart disease among others.

The cause of cardiovascular disease varies depending on the specific disorder.

For instance, coronary artery disease, stroke, and periphery artery disease

may be caused by high blood pressure, type 2 diabetes, smoking, lack of

exercise, obesity, and poor diet. Obesity is estimated to account for

approximately 5 % of cardiovascular disease.

7




Cetilistat, therefore, reduces the risk of cardiovascular disease by treating

obesity and encouraging a healthy diet that plays role in preventing the

occurrence of heart disorders.

In a 12 week randomized, double-blind study involving obese patients with

diabetes mellitus, cetilistat was administered at 40, 80, or 120 mg three times

daily. The participants were also advised to maintain a low-fat diet during the

study period.

This study reported a significant weight reduction as well as improved glycemic

control. In addition, there was a significant reduction in waist circumference

which one of the risk factors in cardiovascular disease.

May lower your blood pressure

High blood pressure also referred to as hypertension is a condition in which the

force of blood against the arteries’ walls stays elevated over some time.

Hypertension is dangerous as it forces the heart to work too hard leading to the

hardening of the arteries.

Hypertension is associated with some life-threatening diseases such as stroke,

kidney, and liver diseases among others.

Being overweight or obese raises your chances of developing high blood

pressure. Your blood pressure increases with an increase in weight.

It, therefore, means that losing weight is one of the ways to lower your blood

pressure. This is where cetilistat comes in because it leads to significant

weight loss over a short time.

7. Where can I buy Cetilistat?

If you consider using cetilistat buy online at the comfort of your home. Cetilistat

powder is available online in cetilistat suppliers or cetilistat manufacturers

stores. Wuhan Wingroup is one of the cetilistat manufacturers who sell quality

products with very good customer service.

When buying cetilistat powder or otherwise cetilistat capsules from Wingroup

or other cetilistat suppliers carefully check the labels for proper use of the drug.

Consider the recommended cetilistat dosage as directed by the cetilistat

manufacturer but also follow recommendations by your health care provider.

8




Reading cetilistat reviews from personal experiences may assist you to get a

better understanding of its efficacy as well as safety. Most customers of

cetilistat buy online and may leave cetilistat reviews based on their personal

experiences.

Cetilistat price is also a consideration when you want to buy it. Wingroup is one

of the cetilistat suppliers who may be offering a competitive cetilistat price.

However, cetilistat prices should not blind you to choose a poor quality

product.

Buying from the comfort of your home may be tempting to make hasty

purchases, however, you still need to make proper arrangements to know the

availability of the drugs you require beforehand.

References

1. Bryson, A., de la Motte, S., & Dunk, C. (2009). Reduction of dietary fat absorption

by the novel gastrointestinal lipase inhibitor cetilistat in healthy volunteers. British

journal of clinical pharmacology, 67(3), 309–315.

https://doi.org/10.1111/j.1365-2125.2008.03311.x.

2. Hainer V. (2014). Overview of new antiobesity drugs. Expert opinion on

pharmacotherapy, 15(14), 1975–1978.

https://doi.org/10.1517/14656566.2014.946904.

3. Kopelman, P., Groot, G., Rissanen, A., Rossner, S., Toubro, S., Palmer, R., Hallam,

R., Bryson, A., & Hickling, R. I. (2010). Weight loss, HbA1c reduction, and

tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese

diabetics: comparison with orlistat (Xenical). Obesity (Silver Spring, Md.), 18(1),

108–115. https://doi.org/10.1038/oby.2009.155.

4. Kopelman, P; Bryson, A; Hickling, R; Rissanen, A; Rossner, S; Toubro, S; Valensi,

P (2007). "Cetilistat (ATL-962), a novel lipase inhibitor: A 12-week randomized,

placebo-controlled study of weight reduction in obese patients". International

Journal of Obesity. 31 (3): 494–9. doi: 10.1038/sj.ijo.0803446. PMID 16953261.

5. Padwal, R (2008). "Cetilistat, a new lipase inhibitor for the treatment of obesity".

Current Opinion in Investigational Drugs. 9 (4): 414– PMID 18393108.

6. Yamada Y, Kato T, Ogino H, Ashina S, Kato K (2008). "Cetilistat (ATL-962), a novel

pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid

profiles in rats". Hormone and Metabolic Research. 40 (8): 539–

doi:10.1055/s-2008-1076699. PMID 18500680. S2CID 29076657.

9


Fat killer--Cetilistat VS Orlistat

Create successful ePaper yourself

Delete template?

Save as template?