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The Great American Drug Deal: A New
Prescription for Innovative and Affordable
Medicines
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Developing life-changing drugs is risky and expensive, but
that’s not what makes them unaffordable. Drug pricing is a
staple of every news cycle and political debate. And while
we’ve struggled for decades to agree on solutions that serve
all patients without jeopardizing the invention of new
medicines, many Americans suffer because they can’t afford
the drugs they need. Do we really have to choose between
affordability and innovation? In The Great American Drug
Deal, scientist and industry expert Peter Kolchinsky answers
this question with a decisive 'no'. The pharmaceutical
industry’s commitment to creating new lifesaving drugs
destined to become inexpensive generics can be balanced by
the healthcare system’s commitment to making those drugs
affordable for all patients - a biotech social contract. Through
deep research and compelling stories of breakthroughs and
breakdowns, Kolchinsky presents solutions for striking a
balance that are bold yet realistic and tackle today’s most
pressing questions, including: Why doesn’t insurance make
drugs affordable? How can we prevent price-jacking of older
drugs? Why are drugs more expensive in America
than elsewhere? How can we guarantee that all medicines
eventually go generic so they are only temporarily expensive?
What systemic failures led to the opioid crisis, and how can we
prevent the next one? The Great American Drug Deal offers
clear-eyed scrutiny of all players in the industry and examines

vital ideas for closing loopholes, encouraging investment,
dealing with bad actors, and educating consumers. It’s time we
resolve to support patients and fuel discoveries that ease
suffering now and for generations to come. em em
Developing life-changing drugs is risky and expensive, but
that’s not what makes them unaffordable. Drug pricing is a
staple of every news cycle and political debate. And while
we’ve struggled for decades to agree on solutions that serve
all patients without jeopardizing the invention of new
medicines, many Americans suffer because they can’t afford
the drugs they need. Do we really have to choose between
affordability and innovation? In The Great American Drug
Deal, scientist and industry expert Peter Kolchinsky answers
this question with a decisive 'no'. The pharmaceutical
industry’s commitment to creating new lifesaving drugs
destined to become inexpensive generics can be balanced by
the healthcare system’s commitment to making those drugs
affordable for all patients - a biotech social contract. Through
deep research and compelling stories of breakthroughs and
breakdowns, Kolchinsky presents solutions for striking a
balance that are bold yet realistic and tackle today’s most
pressing questions, including: Why doesn’t insurance make
drugs affordable? How can we prevent price-jacking of older
drugs? Why are drugs more expensive in America
than elsewhere? How can we guarantee that all medicines
eventually go generic so they are only temporarily expensive?
What systemic failures led to the opioid crisis, and how can we
prevent the next one? The Great American Drug Deal offers
clear-eyed scrutiny of all players in the industry and examines
vital ideas for closing loopholes, encouraging investment,
dealing with bad actors, and educating consumers. It’s time we
resolve to support patients and fuel discoveries that ease
suffering now and for generations to come. em em