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3. Physico-chemical Methods

Coacervation phase separation:

• Coacervation means the separation of a liquid or phase when solution of two hydrophilic colloids are

mixed under suitable conditions.

• In this method, the three immiscible phases of core material, solvent and coating material are formed

followed by deposition of coating material on the core.

• The coating material is dissolved in a suitable solvent and the core material is uniformly dispersed in the

solution of the coating material.

• Then the coating material is phased out of its solution which starts getting deposited on the particles of

the core material.

Coat formation during coacervation-phase separation process consists of three steps carried out under

continues agitation

i. Formation of 3 immiscible phases (core material, coating material phase, liquid phase).

ii. Deposition of polymer on core material.

iii. Rigorization of coating material.

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