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Immunologic Defects in Laboratory Animals 2
Product details
Publisher : Springer; 1st edition (October 31, 1981)
Language : English
Hardcover : 402 pages
ISBN-10 : 030640673X
ISBN-13 : 978-0306406737
Item Weight : 1.93 pounds
Best Sellers Rank: #2,782,769 in Books (See Top 100 in Books)
#36 in Veterinary Immunology
#380 in Immunology (Books)
#941 in General (Books)
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Tiselius demonstrated that the immunologically active components of
immune sera migrated electrophoretically in the gamma globulin region. His
findings illuminated the classic observations of Jenner regarding
development of resistance to infection, and those of von Pirquet, Pasteur, and
Arthus regarding the transfer and specificity of resistance. Conceptual
integration of these observations provided the impetus for the present modern
era of immunology. Subsequent to Tiselius's work, multiple, rapid advances
have occurred in the study of congenital and acquired immune deficiency
states in mice, chickens, and humans. These studies have readily
demonstrated that the immunologic ability of an organ ism to protect itself
from environmental influences is a prerequisite for survival. Indeed, this
necessity for protection from microenvironmental influences has promoted
the evolu tionary development of immunologic diversification, namely, host
dependence upon a sophisticated, multifaceted network of cells and effector
mechanisms responsible for the clearance and neutralization of toxins and
potentially harmful pathogens. The obligate dependence of animals upon the
functional integrity of their immunologic systems is illus trated by the ready
invasion of ubiquitous organisms when the host is in a state of immune
defense derangement. Nevertheless, derangements in immune function can
range from par tial to complete and can be compatible with survival. The
consequences of such derange ments run the gamut from subclinical disease
to inevitable mortality.
Immunologic Defects in Laboratory Animals 2 by M. Eric Gershwin|Bruce Merchant

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