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EULAR 2002

Congress Preview

axSpA

Steering Committee Introduction

Dear CSF Member,

Welcome to this year’s selection of EULAR abstracts on axSpA and my ‘Top Picks’. Within these pages you’ll find 22 abstracts

that we at the CSF think you’ll find interesting.

On Day 1 we have the AxSpA Drug Treatment: New and Old Drugs session, which is packed full of interesting oral presentations

and definitely not one to be missed. Amongst our selections are presentations on upadacitinib (OP0016), ixekizumab (OP0017),

bimekizumab (OP0019) and secukinumab (OP0023), as well as NSAIDs (OP0018 and OP0021) and the impact of sex differences

on TNFi effectiveness (OP0020).

The AxSpA: About Treatments and Outcomes poster session on Day 4 is another must-see. There you’ll find posters on tofacitinib

(POS0296 and POS0305), secukinumab (POS0297, POS0299 and POS0300), ixekizumab (POS0301) and upadacitinib (POS0306).

This year, we’re producing separate highlights brochures for axSpA, PsA and RA, so make sure to go to the Cytokine Signalling

Forum and download our other highlights brochures. If you’re looking for the latest on lupus, head over to

https://www.lupus-forum.com/ where you’ll find their EULAR selections

As always, thank you for your continued support. We hope you have a fantastic time at EULAR 2022 – especially if this is your first

in-person congress for a while!

Kind regards

Professor Atul Deodhar

Key Presentations

Chairman’s Picks

Wednesday, 01 June 2022

All day POSTER VIEW 6

POS0930

POS0931

POS0937

POS0938

POS0939

POS0949

14:15–

15:30

Safety and efficacy of ixekizumab treatment in patients with axial spondyloarthritis: 3-year clinical trial results from

the COAST programme

Atul Deodhar

Efficacy and improvement in patient-reported outcomes at weeks 16 and 52 in ixekizumab treated biological naïve

patients with radiographic axial spondyloarthritis achieving clinically important pain at night reduction at week 16:

results from COAST-V trial

Sofia Ramiro

MEASURE 2: Secukinumab provides rapid and sustained relief from key clinical symptoms of active ankylosing

spondylitis in TNFi-naïve patients through 5 years

Karel Pavelka

Maintenance of response to bimekizumab over 3 years of treatment in patients with active ankylosing spondylitis:

post hoc analyses from the BE AGILE study and its open-label extension

Victoria Navarro-Compán

Bimekizumab in patients with active non-radiographic axial spondyloarthritis: 24-week efficacy & safety from

BE MOBILE 1, a phase 3, multicentre, randomised, placebo‐controlled study

Xenofon Baraliakos

No change in serum levels of bone turnover markers corrected for age and gender during the first year of secukinumab

treatment in patients with ankylosing spondylitis

Mark Siderius

EULAR RECOMMENDATIONS SESSION

Update of the ASAS/EULAR recommendations on the management of axial spondyloarthritis

Sofia Ramiro

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Chairman’s Picks

16:30–

18:00

OP0016

OP0017

OP0018

OP0019

OP0020

OP0021

OP0023

16:30–

18:00

OP0034

AxSpA DRUG TREATMENT: NEW AND OLD DRUGS

Efficacy and safety of upadacitinib in patients with active non-radiographic axial spondyloarthritis:

a double-blind, randomized, placebo-controlled phase 3 trial

Filip van den Bosch

Recapture rates with ixekizumab after withdrawal of therapy in patients with axial spondyloarthritis:

results at week 104 from a randomized placebo-controlled withdrawal study

Robert B.M. Landewé

Comparison of the effect of treatment with NSAIDs added to anti-TNF therapy versus anti-TNF therapy alone on

progression of StrUctural damage in the spine over two years in patients with ankyLosing spondylitis (CONSUL) –

an open-label, randomized controlled, multicenter trial

Fabian Proft

Bimekizumab in patients with active ankylosing spondylitis: 24-week efficacy & safety from BE MOBILE 2,

a phase 3, multicentre, randomised, placebo-controlled study

Désirée van der Heijde

Sex differences in effectiveness of first-line tumor necrosis factor inhibitors in axial spondyloarthritis; results from

fifteen countries in the EuroSpA Research Collaboration Network

Pasoon Hellamand

Treatment with non-steroidal anti-inflammatory drugs is associated with retardation of radiographic spinal progression

in patients with axial spondyloarthritis: 10-year results from the GErman SPondyloarthritis Inception Cohort

Murat Torgutalp

A randomized, double-blind trial comparing secukinumab 300 mg and 150 mg at Week 52 in patients with

ankylosing spondylitis who did not achieve inactive disease during an initial 16 weeks of open-label treatment with

secukinumab 150 mg

Marina Magrey

FROM RISK ASSESMENT TO SOCIETAL OUTCOMES

Ixekizumab improves signs, symptoms, and quality of life in patients with axial SpA irrespective of disease duration:

results from the COAST-V, COAST-W and COAST-X trials

Victoria Navarro-Compán

Saturday, 02 June 2022

10:15–

11:45

POS0296

POS0297

POS0299

POS0300

POS0301

POS0305

POS0306

POSTER TOUR AUDITORIUM 6

AxSpA: ABOUT TREATMENTS AND OUTCOMES

Integrated safety analysis of tofacitinib in ankylosing spondylitis clinical trials

Atul Deodhar

Effectiveness and safety of secukinumab in axial spondyloarthritis: a 24-month prospective, multicenter real-life study

Giacomo Cozzi

Effect of secukinumab on radiographic progression and inflammation in sacroiliac joints and spine in patients with

non-radiographic axial spondyloarthritis: 2-year imaging outcomes from a phase III randomised trial

Juergen Braun

Factors associated with secukinumab (SEC) retention in axial Spondyloarthritis (axSpA): results of the French

retrospective study FORSYA

Maxime Dougados

Structural outcomes in the sacroiliac joint after ixekizumab treatment for 16 weeks in patients with active

non‐radiographic axial spondyloarthritis stratified by gender, HLA-B27, and baseline MRI inflammation

Walter P Maksymowych

Time to improvement of fatigue in patients with ankylosing spondylitis in a study of tofacitinib

Laure Gossec

Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis refractory to biologic therapy:

a double-blind, randomized, placebo-controlled phase 3 trial

Désirée van der Heijde

SPONSORSHIP AND UNRESTRICTED EDUCATIONAL GRANTS FROM

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