Read ebook [PDF] Antibodies and their role in therapeutics: Monoclonal Antibodies | Immunology

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Antibodies and their role in therapeutics: Monoclonal
Antibodies | Immunology | Biotechnology
Sinopsis :
Beginning with the structure, types, functions, and gene
organization of antibodies, the book aims to shine a detailed
light on the monoclonal antibodies (often referred to as mAbs)
that have revolutionized the fields of therapeutics and
diagnostics.The book describes the different ways of
generating chimeric, humanized, and fully human monoclonal
antibodies, emphasizing phage display, hybridoma, and rDNA
technology. In addition, the book focuses on the various
recombinant antibody formats in detail:Drug conjugates:
Antibody-drug conjugates (ADCs), Immunotoxins
(Recombinant, Humanized and Fully Human) and Antibodyantibiotic
conjugate (AAC)Bispecific antibodies: scFv based

(BiTE, DARTs and TandAbs) and Full-length IgG
basedAbzymes and Antibody-directed enzyme prodrug
therapy (ADEPT)Fc-fusion proteinsSingle-domain antibodies
(VHH and IgNAR sdAb)The book discusses the various
therapeutic applications of monoclonal antibodies, along with
the immunogenicity issues. The book also covers the modes of
administration and side effects of monoclonal antibodies, along
with the challenges and issues faced while developing a
monoclonal antibody into a therapeutic agent. Modifications
introduced by the researchers to decrease the immunogenicity
issues and increase the efficacy of therapeutic mAbs are also
described.The book is an invaluable resource for researchers
and students in biology and medicine, biotechnology,
immunology, genetics, molecular biology, and anyone
interested in antibody engineering.