ERIC J. TOPOL, M.D. - Scripps Translational Science Institute

Bibliography | Eric J. Topol, M.D. | June 2011
ERIC J. TOPOL, M.D.
BIBLIOGRAPHY
Original Publications in Scientific Journals
1. Moss AJ, Glaser W, Topol EJ: Atrial tachypacing in the treatment of a patient with primary orthostatic
hypotension. New England Journal of Medicine 302:1456-1457, 1980. [PMID 7374710]
2. Topol EJ, Brodows RD: Effect of indomethacin on acute insulin release in man. Diabetes 29:379-383,
1980. [PMID 6769727]
3. Topol EJ, Goldschlager N, Ports T, DiCarlo L, Schiller N, Botvinick E, Chatterjee K: Hemodynamic
benefit of atrial pacing in right ventricular myocardial infarction. Annals of Internal Medicine 96:594-597,
1982. [PMID 7073152]
4. Topol EJ, Lerman BB: Hypomagnesemic torsade de pointes. American Journal
of Cardiology 52:1367-
1368, 1983. [PMID 6650429]
5. Lerman BB, Topol EJ, Platia EV, Baughman KL: Orthostatic atrial tachy-cardia: Autonomic influence on
atrial pacemakers. American Journal of Cardiology 54:1406-1408, 1984. [PMID 6711447]
6. Topol EJ, Fortuin NJ: Cardiac tumors and carcinoid heart disease. American -Journal of Medicine
77:950-952, 1984. [PMID 6496552]
7. Topol EJ, Weiss JL, Guzman PA, Dorsey Lima S, Blanck TJJ, Humphrey LJ, Baumgartner WA, Flaherty
JT, Reitz BA: Immediate improvement of dysfunc-tional myocardial segments after coronary revascularization:
detection by intraoperative transesophageal echocardi-ography. Journal of American College of
Cardiology 4:1123-1134, 1984. [PMID 6334108]
8. Collen D, Topol EJ, Tiefenbrunn AJ, Gold HK, Weisfeldt ML, Sobel BE, Leinbach RC, Brinker JA,
Ludbrook PA, Yasuda T, Bulkley BH, Robinson AK, Hutter AM, Bell WR, Spadaro JJ, Khaw BA,
Grossbard EB: Coronary thrombo-lysis with -recombinant human tissue type plasminogen activator: a
prospective, randomized, placebo-controlled trial. Circulation 70: 1012-1017, 1984. [PMID 6388898]
9. Topol EJ, Traill TA, Fortuin NJ: Hypertensive hypertrophic cardio-myopathy of the elderly. New England
Journal of Medicine 312:277-283, 1985. [PMID 2857050]
10. Topol EJ, Ciuffo AA, Pearson TA, Dillman JJ, Builder S, Grossbard E, Weisfeldt ML, Bulkley BH:
Thrombolysis with recombinant tissue plasminogen activator in atheroscle-rotic, thrombotic occlusion.
Journal of American College of Cardiology 5:85-91, 1985. [PMID 4038373]
11. Topol EJ, Biern R, Reitz B: Cardiac papillary fibroelastoma and stroke: Echo-cardio-graphic diagnosis
and guide to excision. American Journal of Medicine 80:129-132, 1986. [PMID 3942145]
12. Topol EJ, Humphrey LS, Borkon MA, Baumgartner WA, Reitz BA, Weiss JL: Value of intraoperative left
ventricular microbubbles detected by transesophageal two dimensional echocardiography in predicting
neurologic outcome after cardiac operations. American Journal of Cardiology 56:773-775, 1985. [PMID
4061300]
13. Topol EJ, Weiss JL, Brinker JA, Bulkley BH, Brin KP, Gottlieb SO, Gerstenblith G, Guerci AD, Flaherty
JF, Chandra N, Ouyang P, Gottlieb SH, Becker LB, Weisfeldt ML, Shapiro EP: Regional wall motion
improvement after coronary thrombolysis with recombinant tissue plasminogen activator: importance of
coronary angioplasty. Journal of American College of Cardiology 6:426-433, 1985. [PMID 3160757]
14. Topol EJ, Eha J, Brin KP, Shapiro EP, Weiss JL, Riegel MB, Gottlieb SO, 
Brinker JB: Applicability of
percutaneous trans-luminal coronary angioplasty to patients with recombinant tissue plasminogen activator
mediated thrombo-lysis. Catheterization and Cardiovascular Diagnosis 11:337-348, 1985. [PMID
2931176]
15. Topol EJ, Myler RK, Stertzer SH: Selection of dilatation hardware for PTCA –1985. Catheterization
and Cardiovascular Diagnosis 11:629-637, 1985. [PMID 2936462]
Page 1

16. Topol EJ, Lerman BB, Baughman KL, Platia EV, Griffith LSC: De novo refrac-tory ventricular
tachyarrhythmias after coronary revascu-larization. American Journal of Cardiology 57:57-59, 1986.
[PMID 3484603]
17. Topol EJ, Bell WR, Weisfeldt ML: Coronary thrombolysis with recombinant tissue-type plasminogen
activator: A hematologic and pharmacologic study. -Annals of Internal Medicine 103:837-843, 1985.
[PMID 3933395]
18. Topol EJ, Fung AY, Kline E, Kaplan L, Landis D, Strozeski M, Burney RE, Pitt B, O’Neill WW: Safety of
helicopter transport and out of--hospital intra-venous fibrinolytic therapy in patients with evolving
myocardial infarc-tion. Catheterization and Cardio-vascular Diagnosis 13:151-155, 1986. [PMID
3089627]
19. Topol EJ, Herskowitz A, Hutchins G: Massive hemorrhagic myo-cardial infarction after coronary
thrombolysis. American Journal of Medicine 81:339-343, 1986. [PMID 3090880]
20. Fung AY, Lai P, Topol EJ, Bates ER, Bourdillon PDV, Walton JA Jr, Mancini GBJ, Kryski T, Pitt B, O’Neill
WW: Value of percutaneous transluminal coronary angio-plasty after unsuccessful intravenous
streptokinase therapy in acute myocardial infarction. American Journal of- -Cardiology 58:686-691, 1986.
[PMID 2945418]
21. Wind BE, Snider RA, Buda AJ, O’Neill WW, Topol EJ, Dilworth LR: Pulsed doppler assessment of left
ventricular diastolic filling in coronary artery disease -before and immediately after coronary angioplasty.
American Journal of Cardiology 59:1041-1046, 1987. [PMID 2953227]
22. Myler RK, Topol EJ, Shaw RE, Stertzer SH, Clark DA, Fishman-Rosen J, Murphy MC: Multiple vessel
coronary angioplasty: classifica-tion, results and patterns of restenosis in 494 consecutive patients.
Catheterization and Cardiovascular Diagnosis 13:1-15, 1987. [PMID 2949849]
23. Topol EJ, Morris D, Smalling R, Schumacher R, Taylor CR, Nishikawa A, Liberman HA, Collen D, Tufte
ME, Grossbard E, O’Neill WW: A multicenter, randomized, placebo controlled trial of a new form of
intravenous recombi-nant tissue type plasmino-gen activator (Activase) in acute myocardial
24.
infarction. Journal of American College of Cardiology 9:1205-1213, 1987. [PMID 2953770]
Kircher BE, Topol EJ, O’Neill WW, Pitt B: Prediction of coronary artery recanalization after intra-venous
thrombolytic therapy. American Journal of Cardiology 59:513-515, 1987. [PMID 3825886]
25. Topol EJ, O’Neill WW, Langburd AB, Walton JA, Bourdillon PVD, Bates ER, Grines CL, Schork MA, Kline
E, Pitt B: A randomized, placebo-controlled trial of intra-venous recombinant tissue type plasminogen
activator and emergency coronary angioplasty in patients with acute myocardial infarction. Circulation
75:420-428, 1987. [PMID 2948735]
26. Walsh DG, Kaplan LR, Burney RE, Topol EJ, O’Neill WW: Use of tissue plas-minogen activator in the
emergency department for acute myocardial infarction. Annals of Emergency Medicine 16:243-247, 1987.
[PMID 2949679]
27. Topol EJ, Ellis S, Fishman-Rosen J, Leimgruber P, Myler RK, Stertzer SH, 
O’Neill WW, Douglas JS,
Roubin G, King SE: Multi-center study of percu-taneous trans-luminal angioplasty for right coronary
artery ostial stenosis. Journal of American College of Cardiology 9:1214-1218, 1987. [PMID 2953771]
28. O’Neill WW, Topol EJ, Fung AY, Bourdillon PDV, Nicklas JM, Walton JA, Bates ER, Pitt B: Coronary
angioplasty as therapy for acute myocardial infarc-tion: University of Michigan experience. Circulation
76(Suppl II):II-79-87, 1987. [PMID 2955959]
29. Pitt B, Topol EJ, O’Neill WW: Role of percutaneous transluminal coronary angioplasty in acute
myocardial infarction. American Journal of Cardiology 60:185-187, 1987. [PMID 2955691]
30. Bates ER, Topol EJ, Kline EM, Langburd AB, Fung AY, Walton JA Jr, Bourdillon PDV, Vogel RA, Pitt B,
O’Neill WW: Early reperfusion therapy improves left -ventricular function after acute inferior myocardial
infarction associated with right coronary artery disease. American Heart Journal 114:261-267, 1987.
[PMID 2955688]
31. Sanz ML, Mancini J, LeFree MT, Mickelson JK, Starling MR, Vogel RA, Topol EJ: Variability of
quantitative digital subtraction coronary angiography before and -after percutaneous transluminal
Bibliography | Eric J. Topol, M.D. | June 2011
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coronary angioplasty. American Journal of Cardiology 60:55-60, 1987. [PMID 2955693]
32. Topol EJ: Acute intervention for myocardial infarction. Chest 92:929-932, 1987. [PMID 2959455]
33. Topol EJ, Califf RM, Kereiakes DJ, George BS: Thrombolysis and Angio-plasty in Myo-cardial Infarction
(TAMI) trial. Journal of the American College of Cardiology 10:65B-74B, 1987. [PMID 2959716]
34. Topol EJ: Clinical use of streptokinase and urokinase therapy for acute myocardial infarction. Heart and
Lung 16:760-774, 1987. [PMID 3316129]
35. Papadopoulos SM, Chandler WF, Salamat MS, Topol EJ, Sackellares JC: Recom-binant human tissuetype
plasminogen activator therapy in acute thrombotic stroke. Journal of Neurosurgery 67:394-398,
1987. [PMID 3112328]
36. Topol EJ, Califf RM, George BS, Kereiakes DJ, Abbottsmith CW, Candela RJ, 
Lee KL, Pitt B, Stack RS,
O’Neill WW and the Thrombo-lysis and Angioplasty in Myocardial Infarction (TAMI) Study Group: A
random-ized trial of immediate -versus delayed elective angio-plasty after intravenous tissue
plasminogen activator in acute myo-cardial infarction. New England Journal of Medicine 317:581-588,
1987. [PMID 2956516]
37. Topol EJ, Juni JE, O’Neill WW, Nicklas JM, Shea MJ, Burek K, Pitt B: Exercise testing three days after
onset of acute myocardial infarc-tion. American Journal of Cardiology 60:958-962, 1987. [PMID
2960230]
38. Topol EJ, Bates ER, Walton JA Jr, Baumann G, Wolfe S, Maino J, Bayer L, Gorman L, Kline EM, O’Neill
WW: Community hospital administration of intra-venous tissue plasminogen acti-vator in acute
myocardial infarction: improved -timing, thrombo-lytic efficacy and ventricular function. Journal of the
American College of Cardiology 10:1173-1177, 1987. [PMID 3119685]
39. Topol EJ: Advances in thrombolytic therapy for acute myocardial infarction. Journal of Clinical
Pharmacology 27:735-745, 1987. [PMID 3123526]
40. Guerci AD, Gerstenblith G, Brinker JA, Chandra NC, Gottlieb SO, Bahr RD, 
Weiss JL, Shapiro EP,
Flaherty JT, Bush DE, Chew PH, Gottlieb SH, Halperin HR, Ouyang P, Walford GD, Bell WR, Fatterpaker
AK, Llewellyn M, Topol EJ, Healy B, Siu C, Becker LC, Weisfeldt ML: A randomized trial of intravenous
tissue plasminogen activator for acute myocardial infarction with subsequent randomi-zation to elective
coronary angioplasty. New England Journal of Medicine 317:1613-1617, 1987. [PMID 2960897]
41. Topol EJ, George BS, Kereiakes DJ, Candela RJ, Abbottsmith CW, Stump DC, Boswick J, O’Neill WW,
Stack RS, Califf RM, and the TAMI Study Group: Comparison of two dose regimens of intra-venous
tissue plasminogen activator for acute myocardial infarction. American Journal of Cardiology 61:723-728,
1988. [PMID 2965504]
42. Grines CL, Topol EJ, Bates ER, Juni JE, O’Neill WW: Infarct vessel status after intravenous tissue
plasminogen activator and acute coronary angio-plasty: Prediction of clinical outcome. American Heart
Journal 115:1-7, 1988. [PMID 2962478]
43. O’Neill WW, Topol EJ, Pitt B: Reperfusion therapy of acute myocardial infarction. Progress in
Cardiovascular Diseases 30:235-266, 1988. [PMID 3275989]
44. Humphrey LS, Topol EJ, Rosenfeld GI, Borkon AM, Baumgartner WA, Gardner TJ, Maruschak G, Weiss
JL: Immediate enhancement of left ventricular relaxation by coronary artery bypass grafting:
intraoperative assessment. Circulation 77:886-896, 1988. [PMID 3258195]
45. Topol EJ, Burek K, O’Neill WW, Kewman DG, Kander NH, Shea MJ, Schork A, Kirscht J, Juni JE, Pitt B:
A randomized controlled trial of hospital discharge three days after myocardial infarction in the era of
reperfusion. New England Journal of Medicine 318:1083-1088, 1988. [PMID 3281014]
46. Kereiakes DJ, Topol EJ, George BS, Abbottsmith CW, Stack RS, Candela RJ, O’Neill WW, Martin LH,
Califf RM, and the TAMI Study Group: Emergency coronary artery bypass surgery preserves global and
regional left ventricular function after intravenous tissue plasminogen activator therapy for acute
myocardial infarction. Journal of the American College of Cardiology 11:899-907, 1988. [PMID 2965716]
47. Califf RM, Topol EJ, George BS, Boswick J, Lee KL, Stump D, Dillon J, Abbottsmith C, Candela R,
Kereiakes D, O’Neill W, Stack RS, and the TAMI Study Group: Characteris-tics and outcome of patients
Bibliography | Eric J. Topol, M.D. | June 2011
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in whom reperfusion with intravenous tissue-type plasminogen activator fails: results of the Thrombolysis
and Angioplasty in Myocardial Infarction (TAMI) I trial. Circulation 77:1090-1099, 1988. [PMID 2966016]
48. Topol EJ, Califf RM, George BS, Kereiakes DJ, Rothbaum D, Candela RJ, Abbottsmith CW, Pinkerton
CA, Stump DC, Collen D, Lee KL, Pitt B, Kline EM, Boswick J, O’Neill WW, Stack RS, and the TAMI
Study Group: Coronary arterial thrombolysis with combined infusion of recombinant tissue-type
plasminogen -activator and urokinase in patients with acute myocardial infarction. Circulation 77:1100-
1107, 1988. [PMID 2966017]
49. Califf RM, O’Neill W, Stack RS, Aronson L, Mark DB, Mantell S, George BS, Candela RJ, Kereiakes DJ,
Abbottsmith C, Topol EJ and the TAMI Study Group: Failure of simple clinical measurements to predict
perfusion status after intravenous thrombo-lysis. Annals of Internal Medicine 108:658-662, 1988. [PMID
3128953]
50. Topol EJ, Nicklas JM, Kander N, Walton JA, Ellis SG, Gorman L, Pitt B: Coronary revasculariza-tion after
intravenous tissue plasmino-gen activator for unstable angina pectoris: results of a randomized, doubleblind,
placebo-controlled trial. American Journal of Cardiology 62:368-371, 1988. [PMID 2970776]
51. Stump DC, Topol EJ, Chen AB, Hopkins A, Collen D: Monitoring of hemostasis parameters during
coronary thrombolysis with recombi-nant tissue-type plasminogen activator. Thrombosis and
Haemostasis 59:133-137, 1988. [PMID 2455358]
52. Topol EJ: The long-term investment of coronary angioplasty for acute myocardial infarction. Journal of
the American College of Cardiology 11:1150-1152, 1988. [PMID 2966835]
53. Grines CL, O’Neill WW, Anselmo EG, Juni JE, Topol EJ: Compari-son of left -ventricular function and
contractile reserve after successful recanalization by thrombolysis versus rescue percutaneous
transluminal coronary angioplasty for acute myocardial infarction. American Journal of Cardiology
62:352-357, 1988. [PMID 2970774]
54. Topol EJ: An overview of the Thrombolysis and Angioplasty in acute Myo-cardial Infarction (TAMI) trials.
Archives des Maladies du Coeur et des Vaisseaux 81(Suppl I):45-49, 1988. [PMID 2973302]
55. Carlson SE, Aldrich MS, Greenberg HS, Topol EJ: Intracerebral hemorrhage complicat-ing intravenous
tissue plasminogen activator treatment. Archives of -Neurology 45:1070-1073, 1988. [PMID 3140769]
56. Ellis SG, Topol EJ, Gallison L, Grines CL, Langburd AB, Bates ER, Walton JA Jr, O’Neill WW: Predictors
of success for coronary angioplasty performed for acute myocardial infarction. Journal of the American
College of Cardiology 12:1407-1415, 1988. [PMID 2973481]
57. Califf RM, Topol EJ, Stump D, George BS, Boswick JM, Abbottsmith C, Candela R, Kereiakes D, O’Neill
W, Stack RS and the TAMI Study Group: Hemorrhagic complica-tions associated with the use of
intravenous tissue plasminogen activator in treatment of acute myocardial infarction. American Journal of
Medicine 85:353-359, 1988. [PMID 3137818]
58. Werns SW, Topol EJ: Review of hardware for PTCA. Journal of Interventional Cardiology 1:209-219,
1988.
59. Topol EJ, Califf RM, George BS, Kereiakes DJ, Lee KL, for the TAMI Study Group: Insights derived from
the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) trials. Journal of the American College
of Cardiology 12(Suppl A):24A-31A, 1988. [PMID 2973486]
60. Steinberg EP, Topol EJ, Sakin JW, Kahane SN, Appel LJ, Powe, Anderson GF, Erickson JE, Guerci AD:
Cost and procedure implica-tions of thrombo-lytic treatment for acute myocardial infarction. Journal of
the American College of Cardiology 12(Suppl A):58A-68A, 1988. [PMID 3057037]
61. Langburd AB, Topol EJ, Sereika SM, Bates ER, Walton JA Jr, Schork MA, Pitt B, O’Neill WW:
Determinants of left ventricular functional recovery after thrombolytic therapy and/or immediate coronary
angioplasty in acute myocardial infarction. Journal of Interven-tional Cardiology 2:167-174, 1988.
62. Bates ER, O’Neill WW, Topol EJ: Percutaneous atherectomy catheters. Cardiology Clinics 6:373-382,
1988. [PMID 3073007]
63. Topol EJ: Coronary angioplasty for acute myocardial infarction. Annals of Internal Medicine 109:970-
980, 1988. [PMID 2973762]
Bibliography | Eric J. Topol, M.D. | June 2011
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64. Bates ER, Califf RM, Stack RS, Aronson L, George BS, Candela RJ, Kereiakes DJ, Abbottsmith CW,
Anderson L, Pitt B, O’Neill WW, Topol EJ, and the Thrombolysis and Angioplasty in Myocardial Infarction
Study Group: Thrombolysis and Angioplasty in Myocardial Infarction (TAMI-1) Trial: Influence of infarct
location on arterial patency, left ventricular func-tion, and mortality after intravenous tissue plasminogen
activator. Journal of the American College of Cardiology 13:12-18, 1989. [PMID 2521226]
65. Topol EJ: Emerging strategies for failed percutaneous transluminal coronary angioplasty. American
Journal of Cardiology 63:249-250, 1989. [PMID 2521274]
66. Topol EJ, George BS, Kereiakes DJ, Stump DC, Candela RJ, Abbottsmith CW, Aronson L, Pickel A,
Boswick JM, Lee KL, Ellis SG, Califf RM and the TAMI Study Group: A randomized controlled trial of
intra-venous tissue plasminogen -activator and early intravenous heparin in acute myo-cardial infarction.
Circulation 79:281-286, 1989. [PMID 2492454]
67. Ellis SG, Gallison L, Grines CL, Langburd AB, Bates ER, Walton JA Jr., O’Neill WW, Topol EJ: Incidence
and predictors of early recurrent ischemia after successful -percutaneous transluminal coronary
angioplasty for acute myocardial infarction. American Journal of Cardiology 63:263-268, 1989. [PMID
2521536]
68. Nicklas JM, Topol EJ, Kander N, O’Neill WW, Walton JA, Ellis S, Gorman L, 
Pitt B: Randomized,
double-blind, placebo-controlled trial of tissue plasminogen activator in unstable angina. Journal of the
American College of Cardiology 13:434-441, 1989. [PMID 2492325]
69. Holland K, O’Neill WW, Bates ER, Pitt B, Topol EJ: Emergency percutaneous transluminal coronary
angio-plasty during acute myocardial infarction for patients more than 70 years of age. American Journal
of Cardiology 63:399-403, 1989. [PMID 2521765]
70. Loscalzo J, Wharton TP, Kirshenbaum JM, Levine HJ, Flaherty JT, Topol EJ, Ramaswamy K, Kosowsky
BD, Salem DN, Ganz P, Brinker JA, Gurewich V, Muller JE, and the Pro-urokinase for Myocardial
Infarction Study Group: Clot-selective coronary thrombolysis with pro-urokinase. Circula-tion 79:776-
782, 1989. [PMID 2494004]
71. Ellis SG, O’Neill WW, Bates ER, Walton JA, Nabel EG, Topol EJ: Coronary angioplasty as primary
therapy for acute myocardial infarction 6 to 48 hours after symptom onset: Report of an initial
experience. Journal of the American College of Cardiology 13:1122-1126, 1989. [PMID 2522467]
72. Bates ER, Topol EJ: Thrombolytic therapy for acute myocardial infarction. Chest 95:257S-264S, 1989.
[PMID 2523296]
73. Ellis SG, Shaw R, Gershony G, Thomas R, Roubin GS, Douglas JS, Topol EJ, Stertzer SH, Myler RK,
King SB: Risk factors, time course, and treatment effect for restenosis after successful percutaneous
transluminal coronary angioplasty of chronic total occlusion. American Journal of Cardiology 63:897-901,
1989. [PMID 2522727]
74. Ellis SG, Topol EJ: Intracoronary stents: will they fulfill their promise as an -adjunct to angioplasty?
Journal of the American College of Cardiology 13:1425-1430, 1989. [PMID 2522960]
75. Ellis SG, O’Neill WW, Bates EB, Walton JA, Nabel EG, Werns SW, Topol EJ: Implica-tions for patient
triage from survival and left ventricular functional recovery analyses in 500 patients treated with coronary
angioplasty for acute myocardial infarction. Journal of the American College of Cardiology 13:1251-1259,
1989. [PMID 2522954]
76. Topol EJ, Califf RM: Tissue plasminogen activator: Why the backlash? Journal of the American College
of Cardiology 13:1477-1480, 1989. [PMID 2498415]
77. Muller D, Ellis SG, Topol EJ: Atherectomy of the left main coronary artery with percutaneous
cardiopulmonary bypass support. American Journal of Cardiology 64:114-116, 1989. [PMID 2787097]
78. Bates ER, Topol EJ: Early hospital discharge in the myocardial reperfusion era. Clinical Cardiology
12:65-70, 1989. [PMID 2691143]
79. Kereiakes DJ, Topol EJ, Califf RM, George BS, Abbottsmith CW, Stack RS, -Candela RJ, Anderson LC
and the TAMI Study Group: Favorable early and long term prognosis following coronary bypass surgery
therapy for myocardial infarction: results of a multicenter trial. American Heart Journal 118:199-207,
Bibliography | Eric J. Topol, M.D. | June 2011
Page 5

1989. [PMID 2526573]
80. Kander NH, O’Neill W, Topol EJ, Gallison L, Mileski R, Ellis SG: Long term -follow-up of patients treated
with coronary angioplasty for acute myocardial infarction. American Heart Journal 118:228-233, 1989.
[PMID 2526574]
81. Grines CL, Topol EJ, Califf RM, Stack RS, George BS, Kereiakes D, Boswick JM, O’Neill WW and the
TAMI Study Group: Prognostic implications and predictors of enhanced regional wall motion of the
noninfarct zone after thrombolysis and angioplasty therapy of acute myocardial infarction. Circulation
80:245-253, 1989. [PMID 2526697]
82. Stump DC, Califf RM, Topol EJ, Sigmon K, Thornton D, Masek R, Anderson L, Collen D, and the TAMI
Study Group: Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen activator.
Correlation with characteristics of and clinical outcomes in patients with acute myocardial infarction.
Circulation 80:1222-1230, 1989. [PMID 2509104]
83. Topol EJ: Recombinant tissue plasminogen activator: implications in therapy. Seminars in Hematology
and Oncology 26(Suppl 3):25-31, 1989. [PMID 2508227]
84. Topol EJ, Ellis SG, Califf RM, George BS, Stump DC, Bates ER, Nabel EG, 
Walton JA, Candela RJ,
Kline EM, Pitt B, and the Thrombolysis and Angio-plasty in Myocardial Infarction (TAMI) Study Group:
Combined tissue-type plasmin-ogen activator and prostacyclin therapy for acute myocardial infarc-tion.
Journal of the American College of Cardiology 14:877-884, 1989. [PMID 2528903]
85. Ellis SG, Topol EJ, George BS, Kereiakes DJ, Debowey D, Sigmon KN, Pickel A, Lee KL, Califf RM:
Recurrent ischemia without warning. Analysis of risk factors for in-hospital ischemic events following
successful thrombolysis with intravenous tissue plasminogen activator. Circulation 80:1159-1165, 1989.
[PMID 2509102]
86. Holmes DR, Topol EJ: Reperfusion momentum: lessons from the randomized -trials of immediate
coronary angioplasty for acute myocardial infarction. Journal of the American College of Cardiology
14:1572-1578, 1989. [PMID 2809019]
87. Gacioch GM, Topol EJ: Sudden paradoxical clinical deterioration during angioplasty of the occluded
right coronary artery in acute myocardial infarction. Journal of the American College of Cardiology
14:1202-1209, 1989. [PMID 2808974]
88. Califf RM, Topol EJ, Gersh B: From myocardial salvage to patient salvage in acute myocardial
infarction: The role of reperfusion therapy. Journal of the American College of Cardiology 14:1382-1388,
1989. [PMID 2681322]
89. Chapekis AT, Burek K, Topol EJ: The cost:benefit ratio of acute intervention for myocardial infarction:
results of a prospective, matched pair analysis. American Heart Journal 118:878-882, 1989. [PMID
2510487]
90. Ellis SG, Shaw RE, King SB, Myler RK, Topol EJ: Restenosis after excellent angiographic angioplasty
result for chronic total coronary artery occlusion –-Implications for newer percutaneous revascularization
devices. American Journal of Cardiology 64:667-668, 1989. [PMID 2528903]
91. Muller DWM, Topol EJ: Acute myocardial infarction: early and late percutaneous transluminal coronary
angioplasty. Current Opinion in Cardiology 4:524-530, 1989.
92. Topol EJ: Acute myocardial infarction: treatment with thrombolytic therapy. -Clinical Cardiology 7:827-
836, 1989. [PMID 2688884]
93. Sane DC, Califf RM, Topol EJ, Stump DC, Mark DB, Greenberg CS: Bleeding during thrombolytic
therapy for acute myocardial infarction: mechanisms and -management. Annals of Internal Medicine
111:1010-1022, 1989. [PMID 2688504]
94. Burek K, Kirscht J, Topol EJ: Exercise capacity in patients 3 days after acute, -uncomplicated
myocardial infarction. Heart and Lung 18:575-580, 1989. [PMID 2684916]
95. Muller DW, Topol EJ, Califf RM, Sigmon K, George BS, Kereiakes DJ, Candela RJ, Ellis SG, and the
Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group: Relationship between
antecedent angina pectoris and short-term prognosis after thrombolytic therapy for acute myocardial
Bibliography | Eric J. Topol, M.D. | June 2011
Page 6

infarction. American Heart Journal 119:224-231, 1990. [PMID 2405608]
96. Popma JJ, Topol EJ: Factors influencing restenosis after coronary angioplasty. American Journal of
Medicine 88:16N-24N, 1990. [PMID 2195881]
97. Kander NH, Holland KJ, Pitt B, Topol EJ: A randomized pilot trial of brief versus prolonged heparin after
successful reperfusion in acute myocardial infarction. American Journal of Cardiology 65:139-142, 1990.
[PMID 2404389]
98. Vogel R, Shawl F, Tommaso CL, O’Neill W, Overlie P, O’Toole J, Vandormael M, Topol EJ, Tabari KK,
Vogel J, Smith S, Friedmann R, White C, George B, Tierstein P: Initial report of the national registry of
elective cardiopulmonary bypass supported coronary angioplasty. Journal of the American College of
Cardiology 15:23-29, 1990. [PMID 2404047]
99. Topol EJ, Wilson VE: The pivotal role of early and sustained infarct vessel patency in patients with acute
myocardial infarction. Heart and Lung 19:584-593, 1990. [PMID 2228647]
100. Muller DWM, Topol EJ: Unresolved issues: late reperfusion, lytic failure, and reocclusion. Coronary
Artery Disease 1:39-49, 1990. [PMID 10148970]
101. Califf RM, Topol EJ, George BS, Kereiakes DJ, Aronson LG, Martin L, Candela R, Abbottsmith CW,
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102. Kavanaugh KM, Topol EJ: Acute intervention during myocardial infarction in -patients with prior coronary
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104. Muller DWM, Topol EJ: Protected coronary angioplasty: minimizing the hazards of high risk coronary
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106. Ellis SG, Muller DW, Topol EJ: Possible survival benefit from con-comitant beta –but not calcium –
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107. Williams DO, Topol EJ, Califf RM, Roberts R, Mancini J, Joelson JM, Ellis SG: Intravenous recombinant
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108. George BS, Candela RJ, Topol EJ, Stack RS, Kereiakes DJ, Abbottsmith CW, Masek R, Pickel A, Dillon
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109. O’Connor CM, Califf RM, Massey EW, Mark DB, Kereiakes DJ, Candela RJ, Abbottsmith C, George B,
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110. Ohman EM, Califf RM, Topol EJ, Candela RJ, Abbottsmith CW, Ellis SG, 
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115. Muller DWM, Ellis SG, Debowey DL, Topol EJ: Quantitative angiographic -comparison of the immediate
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116. Ellis SG, Vandormael MG, Cowley MJ, DiSciascio G, Deligonul U, Topol EJ, 
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118. Califf RM, Harrelson-Woodlief L, Topol EJ: Left ventricular ejection fraction 
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Phillips HR, Topol EJ, and the TAMI study group: Usefulness of a pericardial friction rub after
thrombolytic therapy during acute myocardial infarction in predicting amount of myocardial damage.
American -Journal of Cardiology 66:1418-1421, 1990. [PMID 2123603]
120. Bates ER, Clemmensen PM, Califf RM, Gorman LE, Aronson LG, George BS, Kereiakes DJ, Topol EJ
and the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group: Precordial ST
segment depression predicts a worse prognosis in inferior infarction despite reperfusion therapy. Journal
of the American College of Cardiology 16:1538-1544, 1990. [PMID 2123903]
121. Muller DWM, Topol EJ: Selection of patients with acute myocardial infarction 
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122. Sane DC, Stump DC, Topol EJ, Sigmon KN, Clair WK, Kereiakes DJ, George BS, Stoddard MF, Bates
ER, Stack RS, Califf RM, and the Thrombolysis and Angio-plasty in Myocardial Infarction Study Group:
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124. Schatz RA, Baim DS, Leon M, Ellis SG, Goldberg S, Hirshfeld JW, Cleman MW, Cabin HS, Walker C,
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Tio F, Almagor Y, Ponder R, Penn IM, Leonard B, Levine SL, Fish RD, Palmaz JC: Clinical experience
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125. Clemmenson P, Bates ER, Califf RM, Hlatky M, Aronson L, George BS, Lee KL, Kereiakes DJ, Gacioch
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126. Topol EJ: Promises and pitfalls of new devices for coronary artery disease. -Circulation 83:689-694,
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127. Nabel EG, Topol EJ, Galeana A, Ellis SG, Bates ER, Werns SW, Walton JA, 
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128. Kereiakes DJ, Topol EJ, George BS, Stack RS, Abbottsmith CW, Ellis S, Candela RJ, Harrelson L,
Martin LH, Califf RM, and the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group:
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130. Ellis SG, Debowey D, Kline E, Bates ER, Topol EJ: Treatment of recurrent ischemia after thrombolysis
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135. Topol EJ, Califf RM: Intravenous heparin, thrombolytics and medical marketing. Journal of
Interventional Cardiology 4:1-4, 1991.
136. Stewart RE, Kander N, Juni JE, Ellis SG, O’Neill WW, Schork MA, Topol EJ, Schwaiger M: Submaximal
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137. Muller DWM, Topol EJ, Ellis SG, Sigmon KN, Lee K, Califf RM, and the Thromboly-sis and Angioplasty in
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prognosis following reperfusion therapy for acute myocardial infarction. American Heart -Journal
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138. Sutton JM, Topol EJ: Significance of a negative exercise thallium test in the -presence of a critical
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139. Mark DB, Sigmon K, Topol EJ, Kereiakes DJ, Pryor DB, Candela RJ, Califf RM: Identification of acute
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Results from the Thrombolysis and Angioplasty in Acute Myocardial Infarction registry. Circulation
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140. Muller DWM, Ellis SG, Topol EJ: Colchicine and antineoplastic therapy for the prevention of restenosis
after percutaneous coronary interventions. Journal of the American College of Cardiology 17:126B-131B,
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141. Califf RM, Topol EJ, Stack RS, Ellis SG, George BS, Kereiakes DJ, Samaha JK, Worley SJ, Anderson
JL, Harrelson-Woodlief L, Wall TC, Phillips HR, Abbottsmith CW, Candela RJ, Wilson B, Sasahara AA,
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use of antagonists to
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of the American College of Cardi-ology 17:89B-95B, 1991. [PMID 2016487]
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144. Schatz RA, Goldberg S, Leon M, Baim D, Hirshfeld J, Cleman M, Ellis S, Topol EJ: Clinical experience
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146. Califf RM, George BS, Ohman EM, Quigley PJ, Topol EJ, Kereiakes DJ, Harrelson L, Candela RJ,
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acute myocardial infarction. American Heart Journal 121:895-901, 1991. [PMID 1900381]
147. Topol EJ, Agnelli G: Strategies for administration of tissue plasminogen activator. Molecular Biology and
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148. Morris JA, Muller DWM, Topol EJ: Combination thrombolytic therapy: a comparison of simultaneous and
sequential regimens of tissue plasminogen activator and urokinase. American Heart Journal 122:375-
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149. Sane DC, Stump DC, Topol EJ, Sigmon K, Kereiakes DJ, George BS, Mantell SJ, Macy E, Collen D,
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151. Kereiakes DJ, Califf RM, George BS, Ellis S, Samaha J, Stack RS, Martin LC, Young SY, Topol EJ, and
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153. Dellborg M, Topol EJ, Swedberg K: Dynamic QRS complex and ST segment vectorcardiographic
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159. Dick RJ, Popma JJ, Muller DW, Burek K, Topol EJ: In-hospital costs associated with new percutaneous
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160. Bates ER, Topol EJ: Limitations of thrombolytic therapy for acute myocardial infarction complicated by
congestive heart failure and cardiogenic shock. Journal of American College of Cardiology 18:1077-
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161. Tenaglia AN, Califf RM, Candela RJ, Kereiakes DJ, Berrios E, Stack RS, 
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162. Kirshenbaum JM, Bahr RD, Flaherty JT, Gurewich V, Levine HJ, Loscalzo J, Schumacher R, Topol EJ,
Wahr D, Braunwald E and the Pro-urokinase for -Myocardial Infarction Study Group: Clot-selective
coronary thrombolysis with low-dose synergistic combinations of single-chain urokinase-type
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163. Muller DM, Ellis SG, Topol EJ: Experimental models of coronary artery restenosis. Journal of American
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164. Wall TC, Califf RM, George BS, Ellis SG, Samaha J, Kereiakes DJ, Worley SJ, Sigmon K, Topol EJ for
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165. Ellis SG, Myler RK, King SB, Douglas JS, Topol EJ, Shaw RE, Stertzer SH, 
Roubin GS: Causes and
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advanced support techniques in high-risk settings. American Journal of Cardiology 68:1447-1451, 1991.
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166. Gacioch GM, Ellis SG, Lee L, Bates ER, Kirsh M, Walton JA, Topol EJ: Cardiogenic shock complicating
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167. Popma JJ, Califf RM, Ellis SG, George BS, Kereiakes DJ, Samaha JK, Worley SJ, Anderson JL, Stump
D, Woodlief L, Sigmon K, Wall TC, Topol EJ: Mechanism of benefit of combination thrombolytic therapy
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169. Holmes DR, Garratt KN, Topol EJ: Coronary angioplasty versus excisional atherectomy trial: CAVEAT.
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170. Popma JJ, De Cesare NB, Ellis SG, Holmes DR, Pinkerton CA, Whitlow P, 
King SB III, Chazzal ZMB,
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171. Topol EJ, Califf RM, Vandormael M, Grines CL, George BS, Sanz ML, Wall T, O’Brien M, Schwaiger M,
Aguirre FV, Young S, Popma JJ, Lee KL, Ellis SG and the Thrombolysis and Angioplasty in Myocardial
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175. Popma JJ, Topol EJ, Hinohara T, Pinkerton CA, Baim DS, King SB, Holmes DR Jr, Whitlow PL,
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perspective of clinical trialists. Clinical Cardiology 15:143-144, 1992. [PMID 1551260]
177. Ellis SG, Van de Werf F, Ribeiro-daSilva E, Topol EJ: Present status of rescue coronary angioplasty:
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178. Ver Lee PN, Muller DWM, Popma JJ, Ellis SG, Topol EJ: A comparison of clinical and quantitative
angiographic outcomes of coronary stenting in elective and emergency settings: a single center
experience. Coronary Artery Disease 2:945-951, 1991.
179. Ellis SG, Myler RK, King SB, Douglas JS, Topol EJ, Shaw RE, Stertzer SH, 
Roubin GS, Murphy, MC:
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180. Chapman GD, Ohman EM, Topol EJ, Candela RJ, Kereiakes DJ, Samaha J, Berrios E, Pieper K, Young
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181. Ellis SG, Savage M, Fischman D, Leon M, Goldberg S, Hirshfeld JW, Baim DS, Cleman MW, Teirstein
PS, Walker C, Bailey S, Topol EJ, Schatz RA: Restenosis after placement of Palmaz-Schatz stents in
native coronary arteries: initial results of a multicenter experience. Circulation 86:1836-1844, 1992.
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182. De Cesare NB, Popma JJ, Holmes DR Jr, Dick RJ, Whitlow PL, King SB, 
Pinkerton CA, Kereiakes DJ,
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184. Topol EJ: The status of research in invasive cardiology. Journal of Invasive -Cardiology 4:10-17, 1992.
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185. Granger CB, Califf RM, Topol EJ: Thrombolytic therapy for acute myocardial infarction. Drugs 44:293-
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186. Topol EJ, Califf RM: Answers to complex questions cannot be derived from “simple” trials. British Heart
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187. Wall TC, Califf RM, Ellis SG, Sigmon K, Kereiakes D, George BS, Samaha J, 
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after thrombolytic therapy. Journal of the American College of Cardiology 21:597-603, 1993.
188. Popma JJ, De Cesare NB, Pinkerton CA, Kereiakes DJ, Whitlow P, King SB, 
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190. Rosenschein U, Yakubov SJ, Guberinich D, Bach DS, Sonda PL, Abrams GD, Topol EJ: Shock wave
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193. Grambow DW, Topol EJ: Effect of maximal medical therapy on refractoriness 
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195. Topol EJ, Califf RM: Thrombolytic therapy for elderly patients. New England Journal of Medicine
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197. Sutton JM, Topol EJ: Left ventricular function assessment and acute myocardial infarction: The role of
left ventricular imaging in establishing diagnosis, prognosis and therapeutic benefit. Current Opinion in
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198. Ellis SG, Tcheng JE, Navetta FI, Muller DW, Weisman HF, Smith C, Anderson KM, Califf RM, Topol EJ.
Safety and antiplatelet effect of murine monoclonal antibody 7E3 Fab directed against platelet
glycoprotein IIb/IIIa in patients undergoing elective coronary angioplasty. Coronary Artery Disease 2:167-
175, 1993.
199. The GUSTO Angiographic Investigators. The effects of tissue plasminogen activator, streptokinase, or
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202. Muller DWM, Topol EJ, Abrams GD, Gallagher KP, Ellis SG: Intramural methotrexate therapy for the
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coronary syndromes. American Journal of Cardiology 73:508-510, 1994.
204. Lincoff AM, Topol EJ, Chapekis AT, George BS, Candela RJ, Muller DWM, Zimmerman CA, Ellis SG:
Intracoronary stenting compared with conventional therapy for abrupt vessel closure complicating
coronary angioplasty: a matched case-control study. Journal of the American College of Cardiology
21:866-875, 1993. [PMID 8450155]
205. Topol EJ: The restenosis “antitheory”. Mayo Clinic Proceedings 68:88-90, 1993. [PMID 8417263]
206. Kalff V, Hicks RJ, Hutchins G, Topol EJ, Schwaiger M: Use of carbon-11 acetate and dynamic positron
emission tomography to assess regional myocardial oxygen consumption in patients with acute
myocardial infarction receiving thrombolysis or coronary angioplasty. American Journal of Cardiology
71:529-535, 1993. [PMID 8438738]
207. Topol EJ, Ellis SG, Cosgrove DM, Bates ER, Muller DWM, Schork N, Schork MA, Loop FD: Analysis of
coronary angioplasty practice in the United States -using a private insurance database. Circulation
87:1489-1497, 1993. [PMID 8141866]
208. Casale PN, Whitlow PL, Franco I, Grigera F, Pashkow FJ, Topol EJ: Comparison of major complication
rates with new atherectomy devices for percutaneous coronary intervention in women versus men.
American Journal of Cardiology 71:1221-1223, 1993. [PMID 8480650]
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Page 13

209. Kleiman NS, Ohman ME, Califf RM, George B, Kereiakes D, Aquirre F, Weisman H, Schaible T, Topol
EJ: Profound inhibition of platelet aggregation with monoclonal antibody 7E3 Fab after thrombolytic
therapy: Results of the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) 8 Pilot Study.
Journal of the American College of Cardiology 22:381-389, 1993. [PMID 8335808]
210. Harrison JK, Califf RM, Harrelson-Woodlief L, Kereiakes D, George BS, Stack RS, Ellis SG, Lee KL,
O’Neill W, Topol EJ, and the TAMI Study Group: Systolic left ventricular function after reperfusion
therapy for acute myocardial infarction: An analysis of determinants of improvement. Circulation
87:1531-1541, 1993. [PMID 8491008]
211. Topol EJ: Rotablator to the rescue. American Journal of Cardiology 71:858-859, 1993. [PMID 8456767]
212. Topol EJ: Cardiac intervention in the elderly: State-of-the-art 1993. Cardiology in the Elderly I:51-53,
1993.
213. Topol EJ, Bonan R, Kakkar VV, de Bono D, Rothman M, Willerson J, Dewart D, Ganz P, Strony J, Cohen
M, Raymond R, Fox I, Maraganore J, Adelman B: Use of an antithrombin, Hirulog, in place of heparin
during coronary angioplasty. Circulation 87:1622-1629, 1993. [PMID 8491018]
214. Lee KS, Topol EJ, Stewart WJ: Atypical presentation of papillary fibroelastoma mimicking multiple
vegetations in a woman with suspected subacute bacterial endo--carditis. American Heart Journal
125:1443-1445, 1993. [PMID 8480605]
215. de Feyter PJ, van Suylen RJ, de Jaegere PPT, Topol EJ, Serruys PW: Interventional techniques for the
treatment of lesions in saphenous venous bypass grafts. Journal of the American College of Cardiology
21:1539-1549, 1993. [PMID 8496517]
216. Lincoff AM, Topol EJ: Trickle down thrombolysis. Journal of the American -College of Cardiology
21:1396-1398, 1993. [PMID 8473647]
217. Krucoff MW, Croll MA, Pope JE, Granger CB, O’Connor Cm, Sigmon KN, Wagner BL, Ryan JA, Lee KL,
Kereiakes DJ, Samaha JK, Worley SJ, Ellis SG, Wall TC, Topol EJ, Califf RM, for the TAMI 7 Study
Group: Continuous 12-Lead ST segment recovery analysis: A noninvasive method for real time detection
of failed myocardial reperfusion. Circulation 88:437-446, 1993. [PMID 8339407]
218. Rosenschein U, Ellis SG, Yakubov SJ, Haudenschild CC, Dick RJ, Topol EJ: Histopathologic correlates
of coronary lesion angiographic morphology: Lessons from a directional atherectomy experience.
Coronary Artery Disease 3:953-961, 1992.
219. Lincoff AM, Topol EJ: The illusion of reperfusion. Does anyone achieve optimal myocardial reperfusion?
Circulation 87:1792-1805 and 88:1361-1374, 1993. [PMID 8353902]
220. Flaherty JT, Pitt B, Gruber JW, Heuser RR, Rothbaum DA, George BS, Burwell LR, Kereiakes DJ,
Deitchman D, Gustafson N, Brinker JA, Becker LC, Mancini GBJ, Topol EJ, Werns SW: Recombinant
human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients
undergoing coronary angioplasty for acute myocardial infarction. Circulation 89:1982-1991, 1994. [PMID
8181121]
221. Nath FC, Muller DWM, Rosenschein U, Ellis SG, Topol EJ: Heparin monitoring during coronary
intervention: Activated clotting time versus activated partial thromboplastin time. Canadian Journal of
Cardiology 9:797-801, 1993. [PMID 8281479]
222. MacIssac A, Thomas J, Topol EJ: Toward the quiescent coronary artery plaque. 
Journal of the
American College of Cardiology 22:1228-1241, 1993. [PMID 8104965]
223. Ellis SG, Tcheng JT, Navetta FI, Muller DWM, Weisman HG, Smith C, Anderson K, Califf RM, Topol EJ:
Safety and antiplatelet effect of fab murine monoclonal antibody 7E3 fab directed against platelet
glycoprotein IIb/IIIa in patients undergoing elective coronary angioplasty – an initial experience.
Coronary Artery -Disease 4:167-175, 1992. [PMID 8269208]
224. Sane DC, Califf RM, Sigmon KN, Topol EJ, Stump DC: Effect of heparin admin-istration on
fibrinogenolysis during thrombolytic therapy with tissue plasminogen activator for acute myocardial
infarction. Fibrinolysis 7:103-107, 1993.
225. Nath FC, Muller DWM, Ellis SG, Rosenschein U, Chapekis A, Quain L, Zimmerman C, Topol EJ:
Bibliography | Eric J. Topol, M.D. | June 2011
Page 14

Thrombosis of a flexible coil coronary stent: frequency, predictors and clinical outcome. Journal of the
American College of Cardiology 21:622-627, 1993. [PMID 8436743]
226. Topol EJ, Plow EF: Clinical trials of platelet receptor inhibitors. Thrombosis and Haemostasis 70:94-98,
1993. [PMID 8236122]
227. Douglas JS, Pepine CJ, Block PC, Brinker JA, Johnson WL, Klinke WP, Levin DC, Mullins CE, Nissen
SE, Topol EJ, Ullyot DJ, Vetrovec GW, Vogel JHK: Recom-mendations for development and
maintenance of competence in coronary interventional procedures. Journal of the American College of
Cardiology 22:629-631, 1993. [PMID 8335841]
228. Ohman EM, Christenson RH, Califf RM, George BS, Samaha JK, Kereiakes DJ, Worley SJ, Wall TC,
Berrios E, Sigmon KN, Lee K, Topol EJ, and the TAMI 7 Study Group: Noninvasive detection of
reperfusion after thrombolysis based on serum creatine kinase MB changes and clinical variables.
American Heart Journal 126:819-826, 1993. [PMID 8213437]
229. Lincoff AM, Califf RM, Ellis SG, Sigmon KN, Lee KL, Topol EJ for the Thrombolysis and Angioplasty in
Myocardial Infarction (TAMI) Study Group: Thrombolytic therapy for women with myocardial infarction: Is
there a gender gap? Journal of the American College of Cardiology 22:1780-1787, 1993. [PMID
8245328]
230. Topol EJ, Leya F, Pinkerton CA, Whitlow PL, Hofling B, Simonton CA, Masden RR, Serruys PW, Leon
MB, Williams DO, King SB, Mark DB, Isner JM, Holmes DR, Ellis SG, Lee KL, Keeler G, Berdan LG,
Hinohara T, Califf RM, on behalf of the CAVEAT Study Group: A comparison of coronary angioplasty with
directional atherectomy in patients with coronary artery disease. New England Journal of Medicine
329:221-227, 1993. [PMID 8316266]
231. Bernardi MM, Califf RM, Kleiman N, Ellis SG, Topol EJ: Lack of usefulness of prolonged bleeding times
in predicting hemorrhagic events in patients receiving the 7E3 glycoprotein IIb/IIIa platelet antibody.
American Journal of Cardiology 72:1121-1125, 1993. [PMID 8237799]
232. DeFranco AC, Topol EJ: Invasive strategies for acute myocardial infarction in the elderly. Cardiology in
the Elderly 2:274-289, 1994.
233. Brown DL, Topol EJ: Stroke complicating percutaneous coronary revascularization. American Journal of
Cardiology 72:1207-1209, 1993. [PMID 8237818]
234 Cosgrove DM, Topol EJ: Perspectives on percutaneous coronary revascularization. Seminars in
Thoracic and Cardiovascular Surgery 6:65-66, April, 1994.
235. Thomas JD, Topol EJ: Wanted: Dead or alive. Assessment of myocardial viability post thrombolysis.
Circulation 88:797-799, 1993. [PMID 8339439]
236. The GUSTO Investigators: An international randomized trial com-paring four thrombolytic strategies for
acute myocardial infarction. New England Journal of Medicine 329:673-682, 1993. [PMID 8204123]
237. George BS, Voorhees WD, Roubin GS, Fearnot NE, Pinkerton CA, Raizner AE, King SB, Holmes DR,
Topol EJ, Kereiakes DJ, Hartzler GO: Multicenter investigation of coronary stenting to treat acute or
threatened closure after percutaneous transluminal coronary angioplasty: Clinical and angiographic
outcomes. Journal of the American College of Cardiology 22:135-143, 1993. [PMID 8509533]
238. Topol EJ, Califf RM: Scorecard cardiovascular medicine. Annals of Internal -Medicine 120:65-70, 1994.
[PMID 8250458]
239. Baim DS, Hinohara T, Holmes D, Topol EJ, Pinkerton C, King SB, Whitlow P, Kereiakes D, Farley B,
Simpson JB for the U.S. Directional Coronary Atherectomy Investigator Group: Results of directional
coronary atherectomy during multicenter pre-approval testing. American Journal of Cardiology 72:6E-
11E, 1993. [PMID 8213572]
240. Lefkovits J, Topol EJ: Future direction in thrombolysis for myocardial infarction: what are the
unanswered questions? Coronary Artery Disease 5:306-316, 1994. [PMID 8044342]
241. Ohman EM, Topol EJ, Califf RM, Bates ER, Ellis SG, Kereiakes D, Geroge B, Samaha JK, Kline E,
Sigmon KN, Stack RS and the Thrombolysis Angioplasty in Myocardial Infarction Study Group: An
analysis of the cause of early mortality after administration of thrombolytic therapy. -Coronary Artery
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Page 15

Disease 4:957-964,1993. [PMID 8173712]
242. Topol EJ, Califf RM, Lee KL on behalf of the GUSTO Investigators: The irony of biased editors who write
editorials. British Journal of Clinical Practice 47:283-284, 1993. [PMID 8015584]
243. Sgarbossa EB, Topol EJ: Semantic ambiguity, the “non-”nosology and myocardial infarction. Journal of
Clinical Epidemiology 47:441-446,1994. [PMID 7730869]
244. Villa AE, Guzman LA, Chen W, Golomb G, Levy RJ, Topol EJ: Local delivery of dexamethasone for
prevention of neointimal proliferation in a rat model of balloon arterial injury. Journal of Clinical
Investigation 93:1243-1249, 1994. [PMID 8132764]
245. Cowley MJ, Vandermael M, Topol EJ, Whitlow PL, Dean LS, Bulle TM, Ellis SG for the Multivessel
Angioplasty Prognosis Study (MAPS) Group: Is traditionally defined complete revascularization needed
for patients with multivessel disease treated by elective coronary angioplasty. Journal of the American
College of Cardiology 22:1289-1297, 1993. [PMID 8227782]
246. Paranandi N, Topol EJ: Contemporary clinical trials of restenosis. Journal of Invasive Cardiology 6:109-
123, 1994. [PMID 10147167]
247. Nicolini FA, Lee P, Rios G, Kottke-Marchant K, Topol EJ: Combination of platelet fibrinogen receptor
antagonist and direct antithrombin inhibitor at low doses markedly improves thrombolysis. Circulation
89:1802-1809, 1994. [PMID 8149546]
248. Nissen SE, Pepine CJ, Bashore TM, Block PC, Bonchek LI, Brinker JA, Carabello B, Douglas JS, Elion
JL, Hirshfeld JW, Holmes DR, Johnson WL, Klinke WP, Levin DC, Mancini GBJ, Mullins CE, Thomas JD,
Topol EJ, Vogel JHK, Wondrow NA: Cardiac angiography without cine film: Erecting a "Tower of Babel"
in the cardiac catheterization laboratory (Position Statement). Journal of the American College of
Cardiology 24:834-837, 1994. [PMID 8077561]
249. Holmes DR, Topol EJ: Dilate or debulk? Cleveland Clinic Journal of Medicine 61:124-126, 1994. [PMID
8194176]
250. Topol EJ: Breaking the thrombolytic gridlock: Insights from the GUSTO trial. Cleveland Clinic Journal of
Medicine 60:445-447, 1993. [PMID 8287504]
251. Topol EJ, Califf RM, Weisman HF, Ellis SG, Tcheng JE, Worley S, Ivanhoe R, George BS, Fintel D,
Weston M, Sigmon K, Anderson KM, Lee KL, Willerson JT on behalf of the EPIC Investigators:
Randomized trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of
clinical restenosis: results at six months. The Lancet 343:881-886, 1994. [PMID 7908357]
252. Topol EJ, Fuster V, Califf RM, Harrington RA, Kleiman NS, Kereiakes DJ, Cohen M, Chapekis A, Gold
HK, Bear P, Rao AK, Debowey D, Schwartz D, Henis M, Chesebro J. Recombinant hirudin for unstable
angina pectoris: A multicenter, -randomized angiographic trial. Circulation 89:1557-1566, 1994. [PMID
8149521]
253. Brown DL, MacIsaac AI, Topol EJ: Pulmonary hemorrhage following intracoronary stent placement.
Journal of the American College of Cardiology 24:91-94, 1994. [PMID 8006287]
254. Topol EJ: Validation of the early open infarct vessel hypothesis. American Journal of Cardiology 72:40G-
45G, 1993. [PMID 8279360]
255. Wall TC, Califf RM, Blankenship J, Talley D, Tannenbaum M, Schwaiger M, Gacioch G, Cohen M, Sanz
M, Leimberger J, Topol EJ and the Thrombolysis and Angioplasty in Myocardial Infarction Research
Group: Intravenous fluosol in the treatment of acute myocardial infarction: results of the Thrombolysis
and Angioplasty in Myocardial Infarction 9 trial. Circulation 90:114-120, -1994. [PMID 8025985]
256. Holmes DR, Topol EJ, Adelman AG, Cohen EA, Califf RM: Randomized trials of directional coronary
atherectomy implications for clinical practice and future investigation. Journal of the American College of
Cardiology 24:431-439, 1994. [PMID 8034880]
257. Lee KL, Califf RM, Van de Werf F, Simes J, Topol EJ on behalf of the GUSTO -Investigators: Holding
GUSTO up to the light. Annals of Internal Medicine 120:876-881, -1994. [PMID 8154647]
258. Ellis SG, Popma JJ, Buchbinder M, Franco I, Leon MB, Kent KM, Pichard D, Satler LF, Topol EJ,
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Page 16

Whitlow PL: Relation of clinical presentation, stenosis morphology and operator technique to the
procedural results of rotational atherectomy. Circulation 89:882-892, 1994. [PMID 8313578]
259. Sullivan E, Kearney M, Isner J, Topol EJ, Losordo DW: Pathology of unstable angina: Analysis of
biopsies obtained by directional coronary atherectomy. Journal of Thrombosis and Thrombolysis 1:63-71,
1994. [PMID 10603514]
260. Sutton JM, Ellis SG, Roubin GS, Pinkerton CA, King SB, Raizner AE, Holmes DR, Kereiakes DJ, Topol
EJ for the Gianturco-Roubin Intracoronary Stent Investigator Group: Major clinical events after coronary
stenting. The multicenter registry of acute and elective Gianturco-Roubin stent placement. Circulation
89:1126-1137, 1994. [PMID 8124799]
261. Harrington RA, Sane DC, Califf RM, Sigmon K, Abbottsmith CW, Candela RJ, Lee KL, Topol EJ, for the
TAMI Study Group: Clinical importance of thrombocytopenia occurring in the hospital phase after
administration of thrombolytic therapy for acute myocardial infarction. Journal of the American College of
Cardiology 23:891-898, 1994. [PMID 810694]
262. Faxon DP, Spiro TE, Minor S, Cote G, Douglas J, Gottlieb R, Califf R, Dorosti K, Topol E, Gordon J and
the ERA Investigators: Low molecular weight heparin in the prevention of restenosis after angioplasty:
The results of the Enoxaparin -Restenosis (ERA) trial. Circulation 90:908-914, 1994. [PMID 8044962]
263. Lefkovits J, Topol EJ: Direct thrombin inhibitors in cardiovascular medicine. Circulation 90:1522-1536,
1994. [PMID 8087958]
264. Hicks RJ, Melon P, Kalff V, Wolfe E, Dick RJ, Popma JJ, Topol EJ, Schwaiger M: Metabolic imaging by
positron emission tomography early after myocardial infarction as a predictor of recovery of myocardial
function following reperfusion. Journal of Nuclear Cardiology 1:124-137, 1994. [PMID 9420679]
265. Domanski MJ, Topol EJ: Cardiogenic shock: progress and residual questions. American Journal of
Cardiology 74:724-726, 1994. [PMID 7942534]
266. Jang Y, Lincoff AM, Plow EF, Topol EJ: Cell adhesion molecules in coronary artery disease. Journal of
the American College of Cardiology 24:1591-1601, 1994. [PMID 7963103]
267. Tcheng JE, Ellis SG, George BS, Kereiakes DJ, Kleiman NS, Talley JD, Wang AL, Weisman HF, Califf
RM, Topol EJ: Pharmacodynamics of chimeric glycoprotein IIb/IIIa integrin antibody fab 7E3 in high risk
coronary angioplasty. Circulation 90:1757-1764, 1994. [PMID 7923659]
268. Savage MP, Fischman DL, Schatz RA, Tierstein P, Leon MB, Baim D, Ellis SG, Topol EJ, Hirshfeld JW,
Cleman MW, Buchbinder M, Bailey S, Heuser R, Walker CG, Curry RC, Gebhardt S, Rake R, Goldberg S
for the Palmaz-Schatz Stent Study Group: Long-term angiographic and clinical outcome after
implantation of a -balloon expandable stent in the native coronary circulation. Journal of the American
College of Cardiology 24:1207-1212, 1994. [PMID 7930240]
269. Ellis SG, da Silva ER, Heyndricks G, Talley JD, Cernigliaro C, Steg G, Spaulding C, Nobuyoshi M, Erbel
R, Vassanelli C, Topol EJ for the RESCUE Investigators: Randomized comparison of rescue angioplasty
with conservative management of patients with early failure of thrombolysis for acute anterior myocardial
infarction. Circulation 90:2280-2284, 1994. [PMID 7955184]
270. Lincoff AM, Topol EJ, Ellis SG: Local drug delivery for the prevention of restenosis: Fact, fancy and the
future. Circulation 90:2070-2084, 1994. [PMID 7923695]
271. Grines CL, Topol EJ, O’Neill WW, George BS, Kereiakes D, Phillips HR, Leimberger JD, Woodlief LH,
Califf RM: Effect of cigarette smoking on outcome after thrombolytic therapy for myocardial infarction.
Circulation 91:298-303, 1995. [PMID 7805231]
272. Kleiman NS, White, Ohman EM, Ross AM, Woodlief L, Califf RM, Holmes DR, Bates E, Pfisterer M,
Vahanian A, Topol EJ: Mortality within 24 hours of thrombolysis for myocardial infarction: the importance
of early reperfusion. Circulation 90:2658-2665, 1994. [PMID 7994805]
273. MacIsaac AI, Ellis SG, Muller DW, Topol EJ, Whitlow PL: Comparison of three coronary stents: clinical
and angiographic outcome after elective placement in 134 consecutive patients. Catheterization and
Cardiovascular Diagnosis 33:199-204, 1994. [PMID 7874711]
274. Braunwald E, Jones RH, Mark DB, Brown J, Brown L, Cheitlin MD, Concannon CA, Cowan MC, Edwards
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Page 17

C, Fuster V, Goldman L, Green LA, Grines CL, Lytle BW, McCauley KM, Mushlin AI, Rose GC, Smith EE,
Swain JA, Topol EJ, Willerson JT: Diagnosing and managing unstable angina. Circulation 90:613-622,
1994. [PMID 8026048]
275. Mark DB, Naylor CD, Hlatky MA, Califf RM, Topol EJ, Granger CB, Knight JD, Nelson CL, Lee KL,
Clapp-Channing N, Sutherland W, Pilote L, Armstrong P: Use of medical resources and quality of life after
acute myocardial infarction in Canada and the United States. New England Journal of Medicine
331:1130-1135, 1994. [PMID 7935638]
276. Becker RC, Charlesworth A, Wilcox R, Hampton J, Skene A, Gore JM, Topol EJ: Cardiac rupture
associated with thrombolytic therapy: impact of time to treatment in the LATE Study. Journal of the
American College of Cardiology 25:1063-1068, 1995. [PMID 7897117]
277. Omoigui N, Topol EJ: Observational versus randomized medical device testing before and after market
approval - The atherectomy versus angioplasty controversy. Controlled Clinical Trials 16:143-149, 1995.
[PMID 7796597]
278. Steinberg JS, Hochman JS, Morgan CD, Dorian P, Theroux P, Topol EJ, Armstrong PW and the LATE
Ancillary Study Investigators: The effects of thrombolytic therapy administered 6-24 hours after
myocardial infarction on the signal-averaged ECG: Results of a multicenter randomized trial. Circulation
90:746-752, 1994. [PMID 8044943]
279. Ellis SG, Lincoff AM, George BS, Kereiakes DJ, Ohman EM, Krucoff MW, Califf RM, Topol EJ, and the
Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group. Randomized evaluation of
coronary angioplasty for early TIMI 2 flow after thrombolytic therapy for the treatment of acute myocardial
infarction: a new look at an old study. Coronary Artery Disease 5:611-615, 1994. [PMID 7952423]
280. Mills P, Rothman MT, Topol EJ. Surgical cover for angioplasty. British Heart Journal 72:506-508, 1994.
281. Lee KL, Woodlief L, Topol EJ, Weaver WD, Betriu A, Col J, Simoons M, Aylward P, Van de Werf F, Califf
RM: Predictors of 30-day mortality in the era of reperfusion for acute myocardial infarction: results from
an international trial of 41,021 patients. Circulation 91:1659-1668, 1995. [PMID 7882472]
282. Boehrer JD, Kereiakes DJ, Navetta FI, Califf RM, Topol EJ for the EPIC Investigators: Effects of
profound platelet inhibition with c7E3 before coronary angioplasty on complications of coronary bypass
surgery. American Journal of Cardiology 74:1166-1170, 1994. [PMID 7977081]
283. Abdelmeguid AE, Whitlow PL, Sapp SK, Ellis SG, Topol EJ. Long-term outcome of transient,
uncomplicated in-laboratory coronary artery closure. Circulation 91:2733-2741, 1995. [PMID 7758178]
284. The GUSTO IIa Investigators. Randomized trial of intravenous heparin versus recombinant hirudin for
acute coronary syndromes. Circulation 90:1631-37, 1994. [PMID 7923645]
285. Holmes DR, Topol EJ, Califf RM, Leya F, Berberg PB, Talley JD, Kellett MA, Shani J, Gottlieb RS,
Whitlow PL, Adelman AG, Pinkerton CA, Lee KL, Pieper K, Keeler GP, Ellis SG for the CAVEAT-II
Investigators: A multicenter, randomized trial of coronary angioplasty versus directional atherectomy for
patients with saphenous vein bypass graft lesions. Circulation 91:1966-1974, 1995. [PMID 7895354]
286. Simes RJ, Topol EJ, Holmes DR, White HD, Rutsch WR, Vahanian A, Simoons ML, Morris D, Betriu A,
Califf RM, Ross AM for the GUSTO-I Investigators. The link between the angiographic substudy and
mortality outcomes in a large randomized trial of myocardial reperfusion: the importance of early and
complete infarct artery reperfusion. Circulation 91:1923-1928, 1995. [PMID 7895348]
287. Reiner JS, Lundergan CF, van den Brand M, Boland J, Thompson MA, Machecourt J, Py A, Pilcher GS,
Fink CA, Burton JR, Simoons ML, Califf RM, Topol EJ, Ross AM, for the GUSTO Angiographic
Investigators. Early angiography cannot predict post-thrombotic coronary reocclusion: Observations from
the GUSTO Angiographic Study. Journal of the American College of Cardiology 24:1439-1444, 1994.
[PMID 7930273]
288. Topol EJ. Validation of the early open infarct vessel hypothesis. American Journal of Cardiology 72:40G-
45G, 1993. [PMID 8279360]
289. Gersh BJ, Topol EJ. Angioplasty or thrombolysis in acute myocardial infarction: dilate or dissolve?
Cleveland Clinic Journal of Medicine 62:15-19, 1995. [PMID 7859398]
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Page 18

290. Ellis SG, Cowley MJ, Whitlow PL, Vandormael M, Lincoff AM, DiSciascio G, Dean LS, Topol EJ for the
Multivessel Angioplasty Prognosis Study (MAPS) Group: Prospective case-control comparison of
percutaneous transluminal coronary revascularization in patients with multivessel disease treated in
1986-87 versus 1991: Improved in-hospital and 12 month results. Journal of the American College of
Cardiology 25:1137-1142, 1995. [PMID 7897127]
291. Elliott JM, Berdan LG, Holmes DR, Isner JM, King SB, Keeler GP, Kearney M, Califf RM, Topol EJ for the
CAVEAT Study Investigators. One-year follow-up in the Coronary Angioplasty versus Excisional
Atherectomy Trial (CAVEAT-I). Circulation 91:2158-2166, 1995. [PMID 7697844]
292. Villa AE, Guzman LA, Poptic E, Labhasetwar V, D’Souza S, Plow EF, Levy RJ, DiCorleto P, Topol EJ:
The effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and
response to vessel wall injury. Circulation Research 76:505-513, 1995. [PMID 7895327]
293. Van de Werf F, Topol EJ, Lee KL, Woodlief LH, Granger CB, Armstrong PW, Barbash GI, Hampton JR,
Guerci A, Simes J, Ross A, Califf RM for the GUSTO Investigators: Variations in patient management and
outcome for acute myocardial infarction in the United States and other countries. Journal of the American
Medical Association 273:1586-1591, 1995. [PMID 7745771]
294. Karnash S, Granger C, White H, Wooflief LH, Topol EJ, Califf RM for the GUSTO Investigators: Treating
menstruating women with thrombolytic therapy: Insights from the GUSTO trial. Journal of the American
College of Cardiology 26:1651-56, 1995. [PMID 7594099]
295. Silver MJ, Sutton JM, Hook S, Lee P, Malycky JL, Ellis SG, Topol EJ, Nicolini FA. Adjunctive selectin
blockade successfully reduces infarct size beyond thrombolytics in the electrolytic canine coronary artery
model. Circulation 92:492-499,1995. [PMID 7543381]
296. Lefkovits J, Plow EF, Topol EJ. Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine. New
England Journal of Medicine 332:1553-1559, 1995. [PMID 7739710]
297. Aguirre FV, Topol EJ, Ferguson JJ, Anderson K, Blankenship JC, Heuser RR, Sigmon K, Taylor M,
Gottlieb R, Hanovich G, Rosenberg M, Donohue TJ, Weisman HF, Califf RM, for the EPIC Investigators:
Bleeding complications with the chimeric antibody to platelet glycoprotein IIb/IIIa integrin in patients
undergoing percutaneous coronary intervention. Circulation 91:2882-2890, 1995. [PMID 7796496]
297A. Belli G, Topol EJ. Part I: Reperfusion and antithrombotic strategies for acute MI. Contemporary
Internal Medicine 7:31-38, 43-45, 1995. [PMID 10150611]
298. Boehrer JD, Ellis SG, Pieper K, Holmes DR, Keeler GP, Debowey D, Chapekis AT, Leya F, Mooney MR,
Gottlieb RS, Serruys PW, Califf RM, Topol EJ for the CAVEAT-I Investigators. Directional atherectomy
versus balloon angioplasty for coronary ostial and non-ostial left anterior descending artery lesions:
results from a randomized, multicenter trial. Journal of the American College of Cardiology 25:1380-
1386, 1995. [PMID 7722137]
299. Topol EJ, Califf RM, Sigmon KA, Lee KL. Thrombolytic therapy for women with acute myocardial
infarction: Is there a gender gap? Cardiovascular Health and Disease in Women 1:22-27, 1995.
300. Lefkovits J, Holmes DR, Califf RM, Safian RD, Pieper K, Keeler G, Topol EJ for the CAVEAT-II
Investigators. Predictors and sequelae of distal embolization during saphenous vein graft intervention
from the CAVEAT-II trial. Circulation 92:734-740, 1995. [PMID 7641351]
301. Lincoff AM, Topol EJ, Sigmon KN, Lee KL, Ohman EM, Rosenschein U, Califf RM, Ellis SG. Significance
of a coronary artery with thrombolysis in myocardial infarction grade 2 flow “patency” (outcome in the
Thrombolysis and Angioplasty in Myocardial Infarction Trials). American Journal of Cardiology 75:871-
876, 1995. [PMID 7732992]
302. Horrigan MG, Topol EJ. Direct angioplasty in acute myocardial infarction state of the art and current
controversies. Cardiology Clinics 13:321-338, 1995. [PMID 7585770]
303. Topol EJ. Novel antithrombotic approaches to coronary artery disease. American Journal of Cardiology
75:27B-33B, 1995. [PMID 7863968]
304. Moliterno DJ, Califf RM, Aguirre FV, Anderson K, Sigmon KN, Weisman HF, Topol EJ for the EPIC Study
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Page 19

percutaneous transluminal coronary angioplasty or directional atherectomy (The EPIC Trial). American
Journal of Cardiology 75:559-562, 1995. [PMID 7887377]
305. Gottsauner-Wolf M, Moliterno DJ, Lincoff AM, Topol EJ. Restenosis - An open file. Clinical Cardiology
19:347-356, 1996. [PMID 8723592]
306. Ellis SG, Miller DP, Brown KJ, Omoigui N, Howell GL, Grierson J, Kutner M, Topol EJ: The in-hospital
cost of percutaneous coronary revascularization: critical determinants and implications. Circulation
92:741-747, 1995. [PMID 7641352]
307. DeLuca SA, Korcuska LA, Oberstar BH, Rosenthal ML, Welsh PA, Topol EJ: Are we promoting true
informed consent in cardiovascular clinical trials? Journal of Cardiovascular Nursing 9:54-61, 1995.
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308. Mark DB, Hlatky MA, Califf RM, Naylor CD, Lee KL, Armstrong PW, Barbash G, White H, Simoons ML,
Nelson CL, Clapp-Channing N, Knight JD, Harrell FE, Simes J, Topol EJ: Cost effectiveness of
thrombolytic therapy with tissue plasminogen activator as compared with streptokinase for acute
myocardial infarction. New England Journal of Medicine 332:1418-1424, 1995. [PMID 7723799]
309. Topol EJ, Block PC, Holmes DR, Klinke WP, Brinker JA. Readiness for the scorecard era in
cardiovascular medicine. American Journal of Cardiology 75:1170-1173, 1995. [PMID 7762507]
310. Williams DO, Baim DS, Bates E, Bonan R, Bost JE, Cowley M, Faxon DP, Feit F, Jones R, Kellett MA,
Kelsey SF, Sopko G, Stadius M, Topol EJ, and BARI Investigators: Coronary anatomic and procedural
characteristics of patients randomized to coronary angioplasty in the Bypass Angioplasty
Revascularization Investigation (BARI). American Journal of Cardiology 75:27C-33C, 1995. [PMID
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311. Tcheng JE, Harrington RA, Kottke-Marchant K, Kleiman NS, Ellis SG, Kereiakes DJ, Mick MJ, Navetta FI,
Smith JE, Worley SJ, Miller JA, Joseph DM, Sigmon KN, Kitt MM, du Mee CP, Califf RM, Topol EJ for the
IMPACT Investigators. Multicenter, randomized, double-blind placebo-controlled trial of the platelet
integrin glycoprotein IIb/IIIa blocker integrelin in elective coronary intervention. Circulation 91:2151-2157,
1995. [PMID 7697843]
312. Holmes DR, Bates ER, Kleiman NS, Sadowski Z, Horgan JH, Morris DC, Califf RM, Berger PB, Topol
EJ: Contemporary reperfusion therapy for cardiogenic shock: The GUSTO I Trial experience. Journal of
the American College of Cardiology 26:668-674, 1995. [PMID 7642857]
313. Omoigui NA, Califf RM, Pieper K, Keeler G, O'Hanesian MA, Berdan LG, Mark DB, Topol EJ for the
CAVEAT Investigators: Peripheral vascular complications in the Coronary Atherectomy Versus Excisional
Atherectomy Trial (CAVEAT). Journal of the American College of Cardiology 26:922-930, 1995. [PMID
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314. Abdelmeguid AE, Whitlow PL, Simpfendorfer C, Sapp SK, Franco I, Ellis SG, Topol EJ. Percutaneous
revascularization of ostial saphenous vein graft stenoses. Journal of the American College of Cardiology
26:955-960, 1995. [PMID 7560623]
315. Topol EJ, Nissen S. Our preoccupation with coronary luminology: the dissociation between clinical and
angiographic findings in ischemic heart disease. Circulation 92:2333-2342, 1995. [PMID 7554219]
316. Christenson RH, Ohman EM, Topol EJ, O'Hanesian M, Sigmon KN, Duh S-H, Kereiakes D, Worley SJ,
George BS, Pizzo CK, Wall TC, Califf RM for the TAMI Study Group. Creatine kinase MM and MB
isoforms in patients receiving thrombolytic therapy and acute angiography. Clinical Chemistry 41:844-
852, 1995. [PMID 7768002]
317. Topol EJ. Prevention of cardiovascular ischemic complications with new platelet glycoprotein IIb/IIIa
inhibitors. American Heart Journal 130:666-672, 1995. [PMID 7668215]
318. Lefkovits J, Topol EJ. Platelet glycoprotein IIb/IIIa receptor inhibitors in ischemic heart disease. Current
Opinion in Cardiology 10:420-6, 1995. [PMID 7549085]
319. Barbash GI, Reiner J, White HD, Wilcox RG, Armstrong PW, Sadowski Z, Morris D, Aylward P, Woodlief
LH, Topol EJ, Califf RM, Ross AM for the GUSTO-I Investigators. Evaluation of the paradoxical
beneficial effects of smoking in patients receiving thrombolytic therapy for acute myocardial infarction:
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Page 20

Mechanism of the “smoker's paradox” from the GUSTO-I trial, with angiographic insights. Journal of the
American College of Cardiology 26:1222-1229, 1995. [PMID 7594035]
320. Moliterno DJ, Harrington RA, Califf RM, Rapold HJ, Topol EJ for the PARADIGM Investigators.
Randomized, placebo-controlled study of Lamifiban with thrombolytic therapy for the treatment of acute
myocardial infarction: rationale and design for the platelet aggregation receptor antagonist dose
investigation and reperfusion gain in myocardial infarction (PARADIGM) study. Journal of Thrombosis
and Thrombolysis 2:165-169, 1995. [PMID 10608020]
321. Jang Y, Guzman LA, Lincoff AM, Gottsauner-Wolf M, Forudi F, Hart CE, Ellis SG, Topol EJ: The
influence of blockade at specific levels of the coagulation cascade on restenosis in rabbit atherosclerotic
femoral artery injury model. Circulation 92:3041-3050, 1995. [PMID 7586275]
322. Gore J, Granger C, Sloan MA, White H, Barbash G, Simoons M, Aylward P, Topol EJ, Califf RM for the
GUSTO Investigators: Stroke occurrence, morbidity and mortality after thrombolytic therapy for acute
myocardial infarction: Results from the GUSTO trial. Circulation 92:2811-2818, 1995. [PMID 7586246]
323. Harrington RA, Lincoff AM, Califf RM, Holmes DR, Berdan LG, O'Hanesian MA, Keeler GP, Garrett K,
Ohman EM, Mark DM, Jacobs AK, Topol EJ for the CAVEAT Investigators: Characteristics and
consequences of myocardial infarction after percutaneous coronary intervention: insights from the
Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT). Journal of the American College of
Cardiology 25:1693-1699, 1995. [PMID 7759725]
324. Robinson K, Mayer EL, Miller DP, Green R, van Lente F, Gupta A, Kottke-Marchant K, Savon SR, Selhub
J, Nissen SE, Kutner M, Topol EJ, Jacobsen DW. Hyperhomocysteinemia and low pyridoxal phosphate:
Common and independent reversible risk factors for coronary artery disease. Circulation 92:2825-2830,
1995. [PMID 7586248]
325. Pilote L, Califf RM, Sapp S, Miller DP, Mark DB, Weaver WD, Gore JM, Armstrong PW, Ohman EM,
Topol EJ. Regional variability in the United States for the management of acute myocardial infarction:
Insights from the GUSTO trial. New England Journal of Medicine 333:565-572, 1995. [PMID 7623907]
326. Topol EJ. The stentor and the sea change. American Journal of Cardiology 76:307-308, 1995. [PMID
7618630]
327. Ellis SG, Omoigui N, Bittl JA, Lincoff AM, Wolfe MW, Howell G, Topol EJ: Analysis of operator-specific
outcomes in interventional cardiology from a multicenter database of 4860 quality-controlled procedures.
Circulation 93:431-439, 1996. [PMID 8565159]
328. Guzman LA, Forudi F, Villa A, Rothlein R, Topol EJ. Role of leukocytes in neointimal formation following
balloon angioplasty in the rabbit atherosclerotic model. Coronary Artery Disease 6:693-701, 1995.
[PMID 8747874]
329. Sgarbossa E, Pinski SL, Barbagelata A, Underwood DA, Gates KB, Topol EJ, Califf RM, Wagner GS.
Electrocardiographic diagnosis of acute myocardial infarction in the presence of left bundle branch block.
New England Journal of Medicine 334:481-487, 1996. [PMID 8559200]
330. Topol EJ. Caveats about elective coronary stenting. New England Journal of Medicine 331:539-541,
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331. Van de Werf F, Califf RM, Armstrong PW, Bates ER, Ross AM, Keiman NS, Topol EJ, on behalf of the
GUSTO-I Steering Committee. Progress culminating from ten years of clinical trials on thrombosis for
acute myocardial infarction. European Heart Journal 16:1024-1026, 1995. [PMID 8665962]
332. White H, Barbash GI, Califf RM, Simes RJ, Granger C, Weaver WD, Kleiman NS, Aylward PE, Gore JM,
Vahanian A, Lee KL, Ross AM, Topol EJ for the GUSTO Investigators: Age and outcome with
contemporary thrombolytic therapy: Results from the GUSTO trial. Circulation 94:1826-1833, 1996.
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333. Granger CB, Hirsh J, Califf RM, Woodlief L, Bovill E, White HD, Topol EJ for the GUSTO Investigators.
Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial
infarction: results from the GUSTO trial. Circulation 93:870-878, 1996. [PMID 8598077]
334. Omoigui NA, Miller DP, Brown KJ, Annan K, Cosgrove D, Lytle BW, Loop F, Topol EJ. Outmigration for
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cardiac surgery in an era of public dissemination of clinical outcomes. Circulation 93:27-33, 1996. [PMID
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335. Weaver WD, White HD, Wilcox RG, Aylward PE, Morris D, Guerci A, Ohman EM, Barbash GI, Betriu A,
Sadowski Z, Topol EJ, Califf RM for the GUSTO-I Investigators. Comparisons of characteristics and
outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy.
Journal of the American Medical Association 275:777-782, 1996. [PMID 8598594]
336. Mak KH, Eisenberg MJ, Eccleston DS, Cornhill JF, Topol EJ. Reusing coronary angioplasty equipment:
technical and clinical issues. American Heart Journal 131:624-630, 1996. [PMID 8604655]
337. Rao AK, Sun L, Chesebro JH, Fuster V, Harrington RA, Schwartz D, Gallo P, Matos D, Topol EJ for
Hirudin in Unstable Angina Trial. Distinct effects of recombinant desulfatohirudin (Revasc) and heparin
on plasma levels of Fibrinopeptide A and prothrombin fragment F1.2 in unstable angina: a multicenter
trial. Circulation 94:2389-2395, 1996. [PMID 8921778]
338. Pilote L, Miller DP, Califf RM, Sunil R, Weaver WD, Topol EJ. Determinants of the use of coronary
angiography and revascularization after thrombolysis for acute myocardial infarction in the United States.
New England Journal of Medicine 335:1198-1205, 1996. [PMID 8815943]
339. Mak KH, Eisenberg MJ, Eccleston DS, Brown KJ, Ellis SG, Topol EJ. Cost-efficacy modeling of catheter
reuse for percutaneous transluminal coronary angioplasty. Journal of the American College of Cardiology
28:106-111, 1996. [PMID 8752801]
340. Johnson TL, Topol EJ. Early, complete infarct vessel patency: arriving at a gold standard for future
clinical investigation in myocardial reperfusion. Journal of Thrombosis & Thrombolysis 4:259-266, 1997.
[PMID 10639267]
341. Eccleston D, Topol EJ. Inhibitors of platelet glycoprotein IIb/IIIa as augmenters of thrombosis.
Coronary Artery Disease 6:947-955, 1995. [PMID 8723017]
342. Harrington RA, Kleiman NS, Kottke-Marchant K, Lincoff AM, Tcheng JE, Sigmon KN, Joseph D, Rios G,
Greenberg C, Kitt MM, Topol EJ, Califf RM. Immediate and reversible platelet inhibition following
administration of a peptide glycoprotein IIb/IIIa inhibitor during percutaneous coronary intervention.
American Journal of Cardiology 76:1222-1227, 1995. [PMID 7503000]
343. Muller DWM, Gordon D, Topol EJ, Levy RJ, Golomb G. Sustained release local hirulog therapy
decreases early thrombosis but not neointimal thickening after arterial stenting. American Heart Journal
131:211-8, 1996. [PMID 8579010]
344. Abdelmeguid AE, Ellis SG, Sapp SK, Whitlow PL, Topol EJ. Defining the appropriate threshold of
creatine kinase elevation after percutaneous coronary interventions. American Heart Journal 131:1097-
1105, 1996. [PMID 8644587]
345. Topol EJ. Potential for a new coronary thrombolytic plateau. Journal of Thrombosis and Thrombolysis
3:127-134, 1996. [PMID 10602553]
346. Lefkovits J, Topol, EJ. Platelet glycoprotein IIb/IIIa receptor antagonists in coronary artery disease.
European Heart Journal 17:9-18, 1996. [PMID 8665658]
347. Barsness GW, Ohman EM, Califf RM, Kereiakes DJ, George BS, Topol EJ. The Thrombolysis and
Angioplasty in Myocardial Infarction (TAMI) Trials: A decade of reperfusion strategies. Journal of
Interventional Cardiology 9:89-115, 1996.
348. Holmes DR, Simpson JB, Berdan LG, Gottlieb RS, Leya F, Keeler GP, Califf RM, Topol EJ, for the
CAVEAT I Investigators. Abrupt closure: The CAVEAT I Experience. Journal of the American College of
Cardiology 26:1494-1500, 1995. [PMID 7594076]
349. Newby LK, Califf RM, Guerci A, Weaver WD, Col J, Horgan JH, Mark DB, Stebbins A, van de Werf F,
Gore J, Topol EJ. Early discharge in the thrombolytic era: an analysis of criteria for uncomplicated
infarction from the GUSTO trial. Journal of the American College of Cardiology 27:625-32, 1996. [PMID
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350. Holmes DR, Isner J, O'Brien M, Califf RM, Topol EJ. Effect of subintimal resection on initial outcome and
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atherectomy: a report from the CAVEAT I and II investigators. Journal of American College of Cardiology
28:645-51, 1996. [PMID 8772751]
351. Barbagelata A, Granger CB, Topol EJ, Worley SJ, Kereiakes DJ, George BS, Ohman EM, Leimberger
JD, Mark DB, Califf RM, for the TAMI Study group. Frequency, significance, and cost of recurrent
ischemia after thrombolytic therapy for acute myocardial infarction. American Journal of Cardiology
76:1007-1013, 1995. [PMID 7484852]
352. Ohman EM, Armstrong PW, Christenson RH, Granger CB, Katus HA, Hamm CW, O'Hanesian MA,
Wagner GS, Kleiman NS, Harrell FE, Califf RM, Topol EJ for the GUSTO-IIa Investigators. Cardiac
Troponin T levels for risk stratification in acute myocardial ischemia. New England Journal of Medicine
335:1333-1341, 1996. [PMID 8857016]
353. Lefkovits J, Ivanhoe RJ, Califf RM, Bergelson BA, Anderson KM, Stoner GL, Weisman HF, Topol EJ for
the EPIC Investigators. Effects of platelet glycoprotein IIb/IIIa receptor blockade by a chimeric
monoclonal antibody improves acute and 6 month outcomes following PTCA for acute myocardial
infarction. Insights from the EPIC Trial. American Journal of Cardiology 77:1045-1051, 1996. [PMID
8644655]
354. Mark DB, Talley JD, Topol EJ, Bowman L, Lam LC, Anderson KM, Jollis JG, Cleman MW, Lee KL,
Aversano T, Untereker WJ, Davidson-Ray L, Califf RM for the EPIC Investigators. Economic assessment
of platelet glycoprotein IIb/IIIa inhibition for prevention of ischemic complications of high risk coronary
angioplasty. Circulation 94:629-35, 1996. [PMID 8772681]
355. Guzman LA, Labhasetwar V, Song C, Jang Y., Lincoff AM., Levy R., Topol EJ. Local intraluminal infusion
of biodegradable polymeric nanoparticles: a novel approach for drug delivery after balloon angioplasty.
Circulation 94:1441-1448, 1996. [PMID 8823004]
356. Redlitz A., Nicolini FA, Malycky JL, Topol EJ, Plow EF. Inducible carboxypeptidase activity: a role in clot
lysis in vivo. Circulation 93:1328-1330, 1996. [PMID 8641019]
357. Eisenberg MJ, Topol EJ. Pre-hospital administration of aspirin in patients with unstable angina and
acute myocardial infarction. Archives of Internal Medicine 156:1506-1510, 1996. [PMID 8687258]
358. Lefkovits J, Califf RM, Anderson KM, Stoner GL, Blankenship JC, Talley JD, Worley SJ, Weisman HF,
Topol EJ for the EPIC Investigators. The increased risk of non Q-wave myocardial infarction following
directional atherectomy is platelet-dependent. Journal of the American College of Cardiology 28:849-
855, 1996. [PMID 8837559]
359. Horrigan MCG, MacIsaac AI, Nicolini FA, Vince DG, Lee P. Ellis SG, Topol EJ. Reduction in myocardial
infarct size by basic fibroblast growth factor following temporary coronary occlusion in a canine model.
Circulation 94:1927-1933, 1996. [PMID 8873670]
360. Califf RM, Lincoff AM, Tcheng JE, Topol EJ. An overview of the results of the EPIC trial. European Heart
Journal 16 (Suppl L):43-49, 1995. [PMID 8869018]
361. LeBreton H, Topol EJ, Plow EF. Evidence for a pivotal role of platelets in vascular reocclusion and
restenosis. Cardiovascular Research 31:235-36, 1996. [PMID 8730399]
362. Newby LK, Rutsch WR, Califf RM, Simoons M, Aylward P, Armstrong PW, Woodlief LH, Lee KL, Topol
EJ, Van de Werf F. Time from symptom onset to treatment in the outcome of patients treated with
thrombolytic therapy. Journal of the American College of Cardiology 27:1646-1655, 1996. [PMID
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363. Van der Giessen WJ, Lincoff AM, Schwartz RS, van Beusekom HMM, Serruys PW, Holmes DR, Ellis SG,
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porcine coronary arteries. Circulation 94:1690-1697, 1996. [PMID 8840862]
364. Lefkovits J, Topol EJ. The clinical role of platelet glycoprotein IIb/IIIa receptor inhibitors in ischemic
heart disease. Cleveland Clinic Journal of Medicine 63:181-189, 1996. [PMID 8665658]
365. Rashid J, Eisenberg MJ, Topol EJ. Cocaine-induced aortic dissection. American Heart Journal
132:1301-4, 1996. [PMID 8969594]
366. Aguirre F, Topol EJ, Anderson K, Kleiman NS, Weisman HF, Califf RM. Clinical benefit within patient
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Page 23

subgroups receiving c7E3 Fab (Abciximab) during percutaneous coronary revascularization: subgroup
analysis from the EPIC Trial. Journal of Invasive Cardiology 8(Suppl B): 21B-32B, 1996.
367. Moliterno DJ, Topol EJ. Another step toward resolving the contrast controversy. Journal of the American
College of Cardiology 27:1387-89, 1996. [PMID 8626948]
368. Schulman SP, Goldschmidt-Clermont PJ, Topol EJ, Califf RM, Navetta FI, Willerson JT, Chandra NC,
Guerci AD, Ferguson JJ, Harrington RA, Lincoff AM, Yakubov SJ, Bahr R, Wolfe CL, Yock PG, Anderson
HV, Nygaard TW, Mason SJ, Effron MB, Brashears L, Gottdiener P, du Mee C, Kitt MM, Gerstenblith G.
The effects of Integrelin, a platelet glycoprotein IIb/IIIa receptor antagonist, in unstable angina: a
randomized multicenter placebo-controlled trial. Circulation 94:2083-2089, 1996. [PMID 8901655]
369. Nicolini FA, Lee P, Malycky JL, Lefkovits J, Kottke-Marchant K, Plow EF, Topol EJ. Selective Inhibition of
factor Xa during thrombolytic therapy markedly improves coronary artery patency in a canine model of
coronary thrombosis. Blood Coagulation and Fibrinolysis 7:39-48, 1996. [PMID 8845461]
370. Califf RM, White HD, Van de Werf F, Sadowski Z, Armstrong PW, Vahanian A, Simoons ML, Simes J, Lee
KL, and Topol EJ, for the GUSTO-I Investigators. One-year results from the global utilization of
streptokinase and t-PA for occluded coronary arteries (GUSTO-I) Trial. Circulation 94:1233-1238, 1996.
[PMID 8822974]
371. Rosenschein U, Topol EJ. Uncoupling clinical outcomes and coronary angiography: a review and
perspective of recent trials in coronary artery disease. American Heart Journal 132:910-920, 1996.
[PMID 883190]
372. Moliterno DJ, Elliott JM, Topol EJ. Randomized trials of myocardial revascularization. Current Problems
in Cardiology XX:121-192, 1995. [PMID 7600846]
373. Mak KH, Moliterno DJ, Granger CB, Miller DP, White HD, Wilcox RG, Califf RM, Topol EJ, and the
GUSTO-I Investigators. The influence of diabetes mellitus on clinical outcome in the thrombolytic era of
acute myocardial infarction. Journal of the American College of Cardiology 30:171-79, 1997. [PMID
9207639]
374. Vogel RA, and Topol EJ. Practice guidelines and physician scorecards: grading the graders. Cleveland
Clinic Journal of Medicine 63:124-128, 1996. [PMID 8819697]
375. Peterson ED, Hathaway WR, Zabel KM, Pieper KS, Granger CG, Wagner GS, Topol EJ, Bates ER,
Simoons ML, Califf RM. The prognostic significance of precordial ST depression in inferior myocardial
infarction in the thrombolytic era: results in 16,521 patients. Journal of the American College of
Cardiology 28:305-312, 1996. [PMID 8800102]
376. Holmes DR, Jr., Califf RM, Topol EJ. Lessons we have learned from the GUSTO trial. Global Utilization
of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries. Journal of the American
College of Cardiology 25(Suppl 7):10S-17S, 1995. [PMID 7775708]
377. Abdelmeguid AE, Topol EJ. The myth of the myocardial "infarctlet" during percutaneous coronary
revascularization procedures. Circulation 94:3369-3375, 1996. [PMID 8989153]
378. Brener SJ, Leya FS, Apperson-Hansen C, Cowley MJ, Califf RM, Topol EJ. A comparison of debulking
versus dilatation of bifurcation coronary lesions: lessons from the CAVEAT-I trial. American Journal of
Cardiology 78:1039-1041, 1996. [PMID 8916485]
379. Almony GT, Lefkovits J, Topol EJ. Antiplatelet and anticoagulant use after myocardial infarction. Clinical
Cardiology 19:357-365, 1996. [PMID 8723593]
380. Topol EJ. Early myocardial reperfusion: an assessment of current strategies in acute myocardial
infarction. European Heart Journal 17(E) 42-48, 1996. [PMID 11824003]
381. Lefkovits J, Malycky JL, Rao JS, Hart CE, Plow EF, Topol EJ, Nicolini FA. Selective inhibition of Factor
Xa is more efficient than Factor VIIa-tissue factor complex blockade at facilitating coronary thrombolysis
in the canine model. Journal of American College of Cardiology 28:1858-65, 1996. [PMID 8962577]
382. Pepine CJ, Holmes DR, Brinker JA, Block PC, Mark DB, Mullins CE, Nissen SE, Topol EJ, Williams DO,
Goldberg S, Serruys PW, and the Cardiac Catheterization Committee. Expert Consensus Document:
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Page 24

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383. Metz BK, and Topol EJ. Heparin as an adjuvant to thrombolytic therapy in acute myocardial infarction.
Biomedicine and Pharmacotherapy 50:243-253, 1996. [PMID 8952863]
384. Langer A, Goodman SG, Topol EJ, Charlesworth A, Skene AM, Wilcox RG, Armstrong PW, for the LATE
Study Investigators. Late Assessment of Thrombolytic Efficacy (LATE) study: Prognosis in patients with
non-Q wave myocardial infarction. Journal of the American College of Cardiology 27:1327-32, 1996.
[PMID 8626939]
385. Ohman EM, Kleiman NS, Gacioch G, Worley SJ, Navetta FI, Talley D, Anderson HV, Ellis SG, Cohen M,
Sprigg D, Miller M, Kereiakes D, Yakubov S, Kitt MM, Sigmon KN, Califf RM, Krucoff MW, Topol EJ, for
the IMPACT-AMI Investigators. Combined accelerated tissue-plasminogen activator and platelet
glycoprotein IIb/IIIa integrin receptor blockade with integrelin in acute myocardial infarction: results of a
randomized, placebo-controlled, dose-ranging trial. Circulation 95:846-854, 1997. [PMID 9054741]
386. Abdelmeguid AE, Topol EJ, Whitlow PL, Sapp SK, Ellis SG. Significance of mild transient release of
creatine kinase-MB fraction after percutaneous coronary interventions. Circulation 94:1528-1536, 1996.
[PMID 8840840]
387. Brener SJ, Ellis SG, Apperson-Hansen C, Leon MB, Topol EJ. Comparison of stenting and balloon
angioplasty for narrowings in aorto-coronary saphenous vein conduits in place for more than 5 years.
American Journal of Cardiology 79:13-18, 1997. [PMID 9024728]
388. Mak KH, Eisenberg MJ, Plante S, Strauss BH, Arheart KL, Topol EJ. Absence of increased in-hospital
complications with reused balloon catheters. American Journal of Cardiology 78:717-719, 1996. [PMID
8831419]
389. Labinaz M, Sketch Jr. MH, Stebbins AL, DeFranco AC, Holmes DR, Kleiman NAS, Betriu A, Rutsch WR,
Vahanian A, Topol EJ, Califf RM, for the GUSTO-I Investigators. Thrombolytic therapy for patients with
prior percutaneous transluminal coronary angioplasty and evolving myocardial infarction. American
Journal of Cardiology 78:1338-1344, 1996. [PMID 8970403]
390. Barbagelata NA, Granger CB, Oqueli E, Suarez LD, Borruel M, Pieper KS, Topol EJ, Califf RM. TIMI
Grade 3 flow and reocclusion after intravenous thrombolytic therapy: a pooled analysis. American Heart
Journal 133:273-82, 1997. [PMID 9060794]
391. GUSTO IIb Investigators. A comparison of recombinant hirudin versus heparin for the treatment of acute
coronary syndromes. New England Journal of Medicine 335:775-82, 1996. [PMID 8778585]
392. Lincoff AM, Tcheng JE, Califf RM, Bass T, Popma JJ, Teirstein PS, Kleiman NS, Hattel L, Anderson HV,
Ferguson JJ, Cabot CF, Weisman HF, Anderson KM, Berdan LG, Musco MH, Topol EJ for the PROLOG
Investigators: Standard versus low dose weight-adjusted heparin in patients treated with the platelet GP
IIb/IIIa receptor antibody fragment c7E3 (Abciximab) Fab during percutaneous coronary
revascularization. American Journal of Cardiology 79:286-291, 1997. [PMID 9036746]
393. Simpfendorfer C, Kottke-Marchant K, Lowrie M, Miller DP, Cove CS, DeFranco AC, Ellis SG, Moliterno
DJ, Raymond RE, Sutton JM, Topol EJ. First chronic platelet glycoprotein IIb/IIIa integrin blockade: a
randomized placebo-controlled pilot study of xemilofiban in unstable angina with percutaneous coronary
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394. Berger PB, Holmes DR, Stebbins AL, Bates ER, Califf RM, Topol EJ. for the GUSTO-I Investigators.
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395. Holmes DR, Califf RM, Van de Werf F, Berger PB, Bates ER, Simoons ML, White HD, and Topol EJ, for
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397. Challapalli R, Lefkovits J, Topol EJ. Clinical trials of recombinant hirudin in acute coronary syndromes.
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402. Berkowitz SD, Granger CB, Pieper KS, Lee KL, Gore JM, Simoons M, Armstrong PW, Topol EJ, Califf
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404. Lincoff AM, Furst JG, Tuch RJ, Ellis SG, and Topol EJ. Sustained local delivery of dexamethasone by a
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405. Mak KH, Challapalli R, Eisenberg MJ, Anderson KM, Califf RM, Topol EJ for the EPIC Investigators.
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406. Aylward PE, Wilcox RG, Horgan JH, White HD, Granger CB, Califf RM, Topol EJ, for the GUSTO-I
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407. Pietila K, Hermens WT, Harmoinen A, Baardman T, Pasternack A, Topol EJ, Simoons ML. Comparison
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409. Woodfield SL, Lundergan CF, Reiner JS, Thompson MA, Rohrbech SC, Deychak Y, Smith JO, Burton JR,
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410. O'Brien JE, Peterson ED, Keeler GP, Berdan LG, Ohman EM, Faxon DP, Jacobs AK, Topol EJ, Califf
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412. Woodfield SL, Lundergan CF, Reiner JS, Greenhouse S, Thompson MA, Rohrbech SC, Deychak Y,
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419. Granger CB, Becker R, Tracy RP, Califf RM, Topol EJ, Pieper KS, Ross AM, Roth S, Lambrew C, Bovill
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421. Lincoff AM, Califf RM, Anderson KM, Weisman HF, Aguirre FV, Kleiman NS, Harrington RA, Topol EJ, for
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422. The GUSTO II Angioplasty Substudy Investigators. A clinical trial comparing primary coronary
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424. Gottsauner-Wolf M, Jang Y, Lincoff AM, Cohen JL, Labhasetwar V, Poptic EJ, Forudi F, Guzman LA,
DiCorleto PE, Levy RJ, Topol EJ, Ellis SG. Influence of local delivery of the protein tyrosine kinase
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425. Gottsauner-Wolf M, Jang Y, Penn MS, Kaplan A, Ellis SG, Chisolm GM, Topol EJ, Lincoff AM.
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428. Forrester JS, Topol EJ, Abele JE, Holmes DR Jr, Skorton DJ. Task Force 5. Assessment, approval, and
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429. Crenshaw BS, Ward SR, Granger CB, Stebbins AL, Topol EJ, Califf RM, for the GUSTO-I trial
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431. Levine GN, Jacobs AK, Keeler GP, Berdan LG, Leya F, Topol EJ, Califf RM, for the CAVEAT-I
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432. Califf RM, Woodlief L, Lee KL, Harrell FE, White H, Guerci A, Barbash G, Simes RJ, Weaver WD,
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433. Zabel KM, Granger CB, Becker RC, Bovill EG, Hirsh J, Aylward PE, Topol EJ, Califf RM for the GUSTO-I
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434. Califf RM, Abdelmeguid A, Kuntz R, Popma JJ, Tardiff BE, Crenshaw B, Bauman RP, Davidson CJ,
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435. Anderson, RD, Ohman EM, Holmes DR, Col J, Stebbins A, Bates ER, Stomel RJ, Granger CB, Topol EJ,
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436. Brieger DB, Topol EJ. Local drug delivery systems and prevention of restenosis. Cardiovascular
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437. Ellis SG, Brener S, DeLuca S, Tuzcu EM, Raymond R, Whitlow PL, and 
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438. Brieger DB, Topol EJ. Hirudin in acute coronary syndromes: when cents override good sense. Journal
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439. Topol EJ, Califf RM, Van de Werf F, Simoons M, Hampton J, Lee KL, White H, Simes J, Armstrong PW
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440. O'Connor CM, Hathaway WR, Bates ER, Leimberger J, Sigmon KN, Kereiakes DJ, George BS, Samaha
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441. Omoigui NA, Silver MJ, Rybicki LA, Rosenthal M, Berdan LG, Pieper K, Califf RM, and Topol EJ for the
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443. Mahaffey KW, Granger CB, Toth C, White HD, Stebbins AL, Barbash GI, Vahanian A, Topol EJ, Califf
RM, for the GUSTO-I Investigators. Diabetic retinopathy should not be a contraindication to thrombolytic
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444. Khan MM, Ellis SG, Aguirre FV, Weisman HF, Wilderman N, Califf RM, Topol EJ, Kleiman NS. Does
intracoronary thrombus influence the outcome of high risk percutaneous transluminal angioplasty?
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Cardiology 31:31-36, 1998. [PMID 9426014]
445. Brieger DB, Mak K-H, White HD, Kleiman NS, Miller DP, Vahanian A, Ross AM, Califf RM, Topol EJ, for
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446. Kleiman NS, Lincoff AM, Kereiakes DJ, Miller DP, Aguirre FV, Anderson K, Weisman HF, Califf RM, Topol
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447. Moliterno DJ, Topol EJ. Conjunctive use of platelet glycoprotein IIb/IIIa antagonists and thrombolytic
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448. The IMPACT II Investigators. Randomised placebo-controlled trial of effect of eptifibatide on
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449. Pfisterer M, Cox JL, Granger CB, Brener S, Naylor CD, Califf RM, Armstrong PW, Van de Werf F,
Stebbins AL, Lee KL, Topol EJ, for the GUSTO Investigators. Atenolol use and clinical outcomes after
thrombolysis for acute myocardial infarction: The GUSTO-I Experience. Journal of the American College
of Cardiology 32:634-40, 1998. [PMID 9741504]
450. The BARI Investigators. The Bypass Angioplasty Revascularization Investigation (BARI): Influence of
diabetes on 5 year mortality and morbidity in a randomized trial comparing CABG and PTCA in patients
with multivessel disease. Circulation 96:1761-1769, 1997. [PMID 9323059]
451. Holmes DR, Topol EJ. Cardiogenic shock: Does it matter where and how a patient is treated?
European Heart Journal 18:1839-1840, 1997. [PMID 9447304]
452. Narins CR, Holmes DR, Topol EJ. A call for provisional stenting: The balloon is back! Circulation
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453. Topol EJ. Towards a new frontier in myocardial reperfusion therapy. Circulation 97:211-218, 1998.
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454. Gebel JM, Sila CA, Sloan MA, Granger CB, Mahaffey KW, Weisenberger J, Green CL, White HD, Gore
JM, Weaver WD, Califf RM, Topol EJ, for the GUSTO-I Investigators. Thrombolysis-related intracranial
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455. Mak K-H, Tan ATH, Chan C, Koh T-H, Topol EJ. The clinical impact of glycoprotein IIb/IIIa receptor
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456. Mahaffey KW, Granger CB, Sloan MA, Thompson TD, Gore JM, Weaver WD, White HD, Simoons ML,
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457. Ghaffari S, Kereiakes DJ, Lincoff AM, Kelly TA, Timmis GC, Kleiman NS, Ferguson JJ, Miller DP, Califf
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458. Christenson RH, Duh S-H, Newby LK, Ohman EM, Califf RM, Granger CB, Pecl S, Pieper KS, Armstrong
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Chemistry 97:494-501, 1998. [PMID 9510853]
459. Brieger DB, Mak K-H, Kottke-Marchant K, Topol EJ. Heparin induced thrombocytopenia. Journal of the
American College of Cardiology 31:1449-1459, 1998. [PMID 9626819]
460. Benzaquen BS, Eisenberg MJ, Challapalli R, Nguyen T, Brown KJ, Topol EJ. Correlates in in-hospital
cost among patients undergoing abdominal aortic aneurysm repair. American Heart Journal 136:696-
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461. Guetta V, Topol EJ. Pacifying the infarct vessel. Circulation 96:713-15, 1997. [PMID 9264471]
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463. Steinhubl S, Topol EJ. Stenting for acute myocardial infarction. Lancet 350:532-33, 1997. [PMID
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464. Kereiakes DJ, Lincoff AM, Miller DP, Tcheng JE, Weisman HF, Anderson KM, Cabot K, Califf RM, Topol
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Favorable effects on stent utilization, clinical outcomes and bleeding complications. Circulation 97:857-
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465. Motwani JG, Topol EJ. Aortocoronary saphenous vein graft disease: pathogenesis, predisposition and
prevention. Circulation 97:916-931, 1998. [PMID 9521341]
466. Sgarbossa EB, Pinski SL, Topol EJ, Califf RM, Barbagelata A, Goodman SG, Gates KB, Granger CB,
Miller D, Underwood DA, Wagner GS, for the GUSTO-I Investigators. Acute myocardial infarction and
bundle branch block at hospital admission: Clinical characteristics and outcomes in the thrombolytic era.
Journal of the American College of Cardiology 31:105-110, 1998. [PMID 9426026]
467. Serebruany VL, Gurbel PA, Shustov AR, Dalesandro M, Gumbs CI, Grabletz LB, Bahr RD, Ohman EM,
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468. Gibler WB, Wilcox RG, Bode C, Castaigne AD, Delooz H, Elich D, Fox KAA, Kereiakes DJ, Rupprecht H,
Topol EJ. Prospective use of glycoprotein IIb/IIIa receptor blockers in the emergency department
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469. Blankenship JC, Hellkamp AS, Aguirre FV, Demko SL, Topol EJ Califf RM, for the EPIC Investigators.
Vascular access site complications after percutaneous coronary intervention with abciximab in the
evaluation of c7E3 for the prevention of ischemic complications (EPIC) trial. American Journal of
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470. Thel MC, Califf RM, Tcheng JE, Sigmon K, Topol EJ, and Ellis SG for the EPIC Investigators. Clinical
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471. Savonitto S, Ardissino D, Granger CB, Morando G, Prando M, Mafrici A, Thompson T, Vahanian A,
Ohman EM, Califf RM, Van de Werf F, Topol EJ. Prognostic value of the admission electrocardiogram in
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472. Kereiakes DJ, Kleiman NS, Ferguson JJ, Masud AZ, Fitzgerald G, Broderick TM, Abbottsmith CW,
Anderson LC, Anders RJ, Dreiling RJ, Hantsbarger GL, Bryzinski B, Topol EJ, for the ORBIT
Investigators. Pharmacodynamic efficacy, clinical safety and outcomes following prolonged platelet
glycoprotein IIb/IIIa receptor blockade with oral xemilofiban: results of a multicenter placebo controlled
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473. Narins CR, Topol EJ. Attention shifts to the white clot. Lancet 350 (Suppl 3):2, 1997. [PMID 9465178]
474. Gurbel PA, Serebruany VL, Shustov AR, Bahr RD, Carpo C, Ohman EM, and Topol EJ for the GUSTO III
Investigators. Effects of reteplase and alteplase on platelet aggregation and major receptor expression
during the first 24 hours of acute myocardial infarction treatment. The GUSTO III platelet study. Journal
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475. The PARAGON Investigators. An international, randomized, controlled trial of lamifiban, a platelet
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476. The PURSUIT (Platelet glycoprotein IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin
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477. Goodman SG, Langer A, Wildermann N, Barbagelata A, Sgarbossa EB, Wagner GS, Granger CB, Califf
RM, Topol EJ, Ross AM, Armstrong PW, for the GUSTO-I Angiographic Investigators. Non-Q vs. Qwave
myocardial infarction after thrombolytic therapy: angiographic and prognostic insights from the
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478. Metz BK, White HD, Granger CB, Simes RJ, Armstrong PW, Hirsh J, Fuster V, MacAulay CM, Califf RM,
Topol EJ, for the GUSTO IIb Investigators. A randomized comparison of direct thrombin inhibition versus
heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: results from the GUSTO IIb
trial. Journal of the American College of Cardiology 31:1493-1498, 1998. [PMID 9626825]
479. Mahaffey KW, Granger CB, Sloan MA, Green CL, Gore JM, Weaver WD, White HD, Simoons ML,
Barbash GI, Topol EJ, Califf RM and the GUSTO-I Investigators. Neurosurgical evacuation of
intracranial hemorrhage following thrombolytic for acute myocardial infarction is associated with improved
outcome: results from the GUSTO-I trial. American Heart Journal 138:493-9, 1999. [PMID 10467200]
480. Alexander KP, Peterson ED, Granger CB, Casas AC, Van de Werf F, Armstrong PW, Guerci A, Topol EJ,
Califf RM, for the GUSTO IIb Investigators. Potential impact of evidence-based medicine in acute
coronary syndromes: insights from GUSTO IIb. Journal of the American College of Cardiology 32:2023-
2030, 1998. [PMID 9857888]
481. Tardiff BE, Califf RM, Tcheng JE, Lincoff AM, Sigmon KN, Harrington RA, Mahaffey KW, Ohman EM,
Blankenship J, Kitt MM, Topol EJ for the IMPACT-II Investigators. Clinical outcomes after detection of
elevated cardiac enzymes in patients undergoing percutaneous intervention. Journal of the American
College of Cardiology 33:88-96, 1999. [PMID 9935014]
482. Harrington RA, Califf RM, Holmes DR, Pieper KS, Lincoff AM, Berdan LG, Thompson TD, and Topol EJ,
for the CAVEAT-I Investigators. Is unstable angina the same? Insights from the Coronary Angioplasty
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483. Hochrein J, Sun F, Pieper KS, Lee KL, Gates KB, Armstrong PW, Topol EJ, Califf RM, Granger CB,
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484. Newby LK, Christenson RH, Ohman EM, Armstrong PW, Peck SL, Lee KL, Hamm CW, Katus HA,
Cianciolo C, Granger CB, Topol EJ, Califf RM, for the GUSTO-IIa Investigators. The value of serial
troponin T measurements for early and late risk stratification in patients with acute coronary syndromes.
Circulation 98:1853-1859, 1998. [PMID 9799204]
485. Topol EJ. Patient stratification and its predictive value for cardiac events. European Heart Journal
19(Suppl K): K5-K7, 1998. [PMID 9790282]
486. Sloan MA, Sila CA, Mahaffey KW, Granger CB, Green CL, Longstreth WT, Koudstaal P, White HD, Gore
JM, Simoons ML, Weaver WD, Topol EJ. Mortality prediction for patients with intracranial hemorrhage
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487. Kleiman NS, Granger CB, White HD, Armstrong P, Ardissino D, Van de Werf F, Zoldeyhi P, Thompson TD,
Califf RM, and Topol EJ for the GUSTO-IIb Investigators. Death and reinfarction within the first 24 hours
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490. Berkowitz SD, Sane DC, Sigmon KN, Shavender JH, Harrington RA, Tcheng JE, Topol EJ, Califf RM, for
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494. Topol EJ and Serruys PW. Frontiers in interventional cardiology. Circulation 98:1802-1820, 1998.
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495. Eisenberg MJ, Taylor JM, Cove CJ, Brown KJ, Ellis SG, Topol EJ. Comparison of percutaneous
coronary revascularization costs among HMO and non-HMO cardiologists practicing in the same
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496. Brener SJ, Barr LA, Burchenal JEB, Katz S, George BS, Jones AA, Cohen ED, Gainey PC, White HJ,
Cheek HB, Moses JW, Moliterno DJ, Effron MB, Topol EJ, on behalf of the RAPPORT Investigators. A
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497. Alexander JH, Granger CB, Sadowski Z, Aylward PE, White HD, Thompson TD, Califf RM, Topol EJ, for
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498. Gurbel PA, Serebruany VL, Shustov AR, Dalesandro M, Gumbs CI, Grablutz LB, Bahr RD, Ohman EM,
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499. Armstrong PW, Fu Y, Chang W-C, Topol EJ, Granger CB, Lee KL, Califf RM for the GUSTO II
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500. Mandak JS, Blankenship JC, Gardner LH, Berkowitz SD, Aguirre FV, Sigmon KN, Timmis GC, Gilchrist
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501. Bhatt DL, Lincoff AM, Kereiakes DJ, Tcheng JE, Godfrey N, Califf RM, Topol EJ. Reduction in the need
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503. Kong DF, Califf RM, Miller DP, Moliterno DJ, Harrington RA, Tcheng JE, Lincoff AM, Hasselblad V, Topol
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504. Steinhubl SR, Lauer MS, Mukherjee DP, Moliterno DJ, Lincoff AM, Ellis SG, Topol EJ. The duration of
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505. Tung CY, Granger CB, Sloan MA, Topol EJ, Knight JD, Weaver WD, Mahaffey KW, White H, Clapp-
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506. Gebel JM, Sila CA, Sloan MA, Mahaffey KW, Granger CB, Weisenberger JP, Green CL, Topol EJ.
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507. Rabbani R, Topol EJ. Strategies to achieve coronary arterial plaque stabilization. Cardiovascular
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508. Hasdai D, Holmes DR, Topol EJ, Berger PB, Criger DA, Hochman JS, Bates ER, Vahanian A, Armstrong
PW, Wilcox R, Ohman EM, Califf RM. Frequency and clinical outcome of cardiogenic shock during acute
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509. Betriu A, Califf RM, Stebbins AL, Guerci A, Topol EJ. Recurrent ischemia after thrombolysis: importance
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510. Berger PB, Tuttle RH, Holmes DR, Topol EJ, Aylward PE, Horgan JH, and Califf RM for the GUSTO I
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511. Simoons ML, van den Brand M, Lincoff M, Harrington R, van der Wieken R, Vanhanian A, Rutsch W,
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512. Topol EJ. Current and emerging antithrombotic therapies for acute coronary syndromes. The Journal of
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513. Topol EJ. The future of antithrombotic and anti-platelet therapy for ischemic heart disease. American
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514. Puma JA, Sketch MH, Thompson TD, Pieper KS, Simes RJ, Morris DC, Topol EJ, Califf RM. Support for
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516. Schwartz RS, Topol EJ, Holmes Jr. DR. Editorial: Artery size, neointima, and remodeling: time for some
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517. Ellis SG, Miller D, Keyes T, Brown K, Ellert R, Howell G, Lincoff AM, Topol EJ. Comparing physicianspecific
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and clinical restenosis following percutaneous coronary revascularization: Insights from the EPIC Trial.
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519. Topol EJ. The drafter and the draftee. Lancet 352:897-98, 1998. [PMID 9743001]
520. Topol EJ. What role for catheter laboratories in unstable angina? Lancet 352:500-501, 1998. [PMID
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521. Marso SP and Topol EJ. The paradoxical benefit of sulfonylurea agents in diabetics undergoing
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522. Gibler WB, Wilcox RG, Bode C, Castaigne AD, Delooz H, Elich D, Fox KAA, Kereiakes DJ, Rupprecht H,
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523. Mak K-H, Kottke-Marchant K, Brooks LM, Topol EJ. In vitro efficacy of platelet glycoprotein IIb/IIIa
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Thrombosis and Haemostasis 80:989-93, 1998. [PMID 9869172]
524. Anderson RD, Ohman EM, Holmes DR Jr, Harrington RA, Wildermann NM, Phillips HR, Topol EJ, Califf
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interventions. Journal of the American College of Cardiology 32:936-941, 1998. [PMID 9768714]
525. The PARADIGM Investigators. Combining thrombolysis with the platelet glycoprotein IIb/IIIa inhibitor
lamifiban: Results of the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion
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526. Newby KH, Thompson T, Stebbins A, Topol EJ, Califf RM, Natale A, for the GUSTO Investigators.
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Circulation 98:2567-73, 1998. [PMID 9843464]
527. Patel VB, Topol EJ. The pathogenesis and spectrum of acute coronary syndromes: From plaque
formation to thrombosis. The Cleveland Clinic Journal of Medicine 66:561-571, 1999. [PMID 10535182]
528. Lincoff AM, Tcheng JE, Califf RM, Kereiakes DJ, Kelly TA, Timmis GC, Kleiman NS, Booth JE, Balog C,
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529. Mahaffey KW, Harrington RA, Simoons ML, Granger CB, Graffagnino C, Alberts MJ, Laskowitz DT, Miller
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Investigators. Stroke in patients with acute coronary syndromes: incidence and outcomes in the platelet
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530. Gilchrist IC, Gardner LH, Muhlestein JB, Arnold AM, Lincoff AM, Califf RM, Tcheng JE, Topol EJ. The
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531. Steinhubl SR, Topol EJ. Clopidogrel with aspirin is the optimal antiplatelet regimen for intracoronary
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532. Topol EJ. Coronary-artery stents--gauging, gorging, and gouging. New England Journal of Medicine
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533. Thel MC, Califf RM, Tardiff BE, Gardner LH, Sigmon KN, Lincoff AM, Topol EJ, Kitt M, Blankenship JC,
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534. Steinhubl SR, Tan WA, Foody JM, Topol EJ, for the EPISTENT Investigators. The incidence and clinical
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535. Alexander JH, Harrington RA, Tuttle RH, Berdan LG, Lincoff AM, Deckers JW, Simoons ML, Guerci A,
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537. Kong DF, Topol EJ, Bittl JA, White HD, Theroux P, Hasselblad V, Califf RM. Clinical outcomes of
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538. Mark DB, Harrington RA, Lincoff AM, Califf RM, Nelson CL, Tsiatis AA, Buell H, Mahaffey KW, Davidson-
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542. Topol EJ, Mark DB, Lincoff AM, Cohen E, Burton J, Kleiman N, Talley D, Sapp S, Booth J, Cabot CF,
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543. Marso SP, Ellis SG, Tuzcu EM, Whitlow PL, Franco I, Raymond RE, Topol EJ. The importance of
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Journal of the American College of Cardiology 33:1269-77, 1999. [PMID 10193727]
544. Holmes DR, White HD, Pieper KS, Ellis SG, Califf RM, Topol EJ. Effect of age on outcome with primary
angioplasty versus thrombolysis. Journal of the American College of Cardiology 33:412-19, 1999.
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545. Miller JM, Smalling R, Ohman EM, Bode C, Betriu A, Kleiman NS, Schildcrout JS, Bastos E, Topol EJ,
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thrombolysis (Reteplase or Alteplase) during acute myocardial infarction: Results from the GUSTO III
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546. Califf RM, Stump D, Topol EJ, Mark DB. The impact of cost-effectiveness study of GUSTO-I on decision
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547. Gassler J and Topol EJ. Reperfusion revisited. Clinical Cardiology 22:IV20-29, 1999. [PMID 10492850]
548. Lincoff AM, Califf RM, Moliterno DJ, Tcheng JE, Ellis SG, Ducas J, Kramer JH, Talley JD, Caramori PO,
Kleiman NS, Cohen EA, Burton JR, Kelly TA, Booth JE, Sapp SK, Ivanc TB, Cabot CF, Topol EJ, for the
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549. Hasdai D, Lerman A, Rihal CS, Garratt KN, Betriu A, White HD, Topol EJ, Granger CB, Ellis SG, Califf
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the American College of Cardiology 36:75-83, 2000. [PMID 10898416]
551. Califf RM, Pieper KS, Lee KL, Van de Werf F, Simes RJ, Armstrong PW, and Topol EJ, for the GUSTO-I
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552. Bruce CJ, Kuntz RE, Popma JJ, Pieper KS, Topol EJ, Holmes Jr. DR. Application of a continuous
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American College of Cardiology 35:619-623, 2000. [PMID 10716463]
553. Hochman JS, Tamis JE, Thompson TD, Weaver WD, Van de Werf F, Aylward P, Topol EJ, Califf RM, for
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555. Asher CR, Topol EJ, Moliterno DJ. Coronary artery disease in Black Americans. Journal of the
American College of Cardiology 138:1073-81, 1999. [PMID 10577437]
556. Boersma E, Pieper KS, Steyerberg EW, Wilcox RG, Chang W-C, Lee KL, Akkerhuis KM, Harrington RA,
Deckers JW, Armstrong PW, Lincoff AM, Califf RM, Topol EJ, Simoons ML, for the PURSUIT
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557. Cohen MG, Granger CB, Ohman EM, Stebbins AL, Grinfeld LR, Cagide AM, Elizari MV, Betriu A, Kong
DF, Topol EJ, Califf RM. Outcome of Hispanic patients treated with thrombolytic therapy for acute
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558. Ohman EM, Armstrong PW, White HD, Granger CB, Wilcox RG, Weaver WD, Gibler WB, Stebbins AL,
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559. Brener SJ, Topol EJ. Logic and logistics: conundrum in reperfusion therapy. Heart 82:402-403, 1999.
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560. Boersman E, Akkerhuis KM, Theroux P, Califf RM, Topol EJ, Simoons ML. Platelet glycoprotein IIb/IIIa
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561. Akkerhuis KM, Deckers JW, Boersma E, Harrington RA, Stepinska J, Mahaffey KW, Wilcox RG, Lincoff
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563. Marso SP, Lincoff AM, Ellis SG, Bhatt DL, Tanguay J-F, Kleiman NS, Hammoud T, Booth JE, Sapp SK,
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564. Hasdai D, Holmes DR Jr, Califf RM, Thompson TD, Hochman JS, Pfisterer M, Topol EJ, for the GUSTO-I
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565. Holmes DR, Berger PB, Hochman JS, Granger CB, Thompson TD, Califf RM, Vahanian A, Bates ER,
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566. Newby LK, Eisenstein EL, Califf RM, Thompson TD, Hasselblad V, Nelson CL, Peterson ED, Armstrong
PW, Van de Werf F, White HD, Topol EJ, Mark DB. Early discharge after acute myocardial infarction:
clinical determinants and cost effectiveness. The New England Journal of Medicine 342:749-755, 2000.
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567. Ellis SG, Guetta V, Miller D, Whitlow PL, Topol EJ. Relation between lesion characteristics and the risk
with percutaneous intervention in the stent and glycoprotein IIb/IIIa era: An analysis of results from
10,907 lesions and proposal for new classification scheme. Circulation 100:1971-1976, 1999. [PMID
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568. Topol EJ, Yadav J. Recognition of the importance of embolization in atherosclerotic vascular disease.
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569. Mak K-H, Topol EJ. Emerging concepts in the management of acute myocardial infarction in patients
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570. Lauer MS, Blackstone EH, Young JB, Topol EJ. Cause of death in clinical research. Journal of the
American College of Cardiology 34:618-620, 1999. [PMID 10483939]
571. Hasdai D, Holmes Jr DR, Criger DA, Topol EJ, Califf RM, Harrington RA for the Platelet Glycoprotein
IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) Trial Investigators.
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572. Hasdai D, Califf RM, Thompson TD, Hochman JS, Ohman EM, Pfisterer M, Bates ER, Vahanian A,
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573. Brener SJ, Barr LA, Burchenal JEB, Wolski KE, Effron MB, Topol EJ, for the RAPPORT Investigators.
Effect of abciximab on the pattern of reperfusion in patients with acute myocardial infarction treated with
primary angioplasty. American Journal of Cardiology 84:728-730, 1999. [PMID 10498145]
574. Christenson RH, Vollmer RT, Ohman EM, Peck S, Thompson T, Duh S-H, Ellis SG, Newby LK, Topol EJ,
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575. The SPEED Group (Strategies for the Patency Enhancement in the Emergency Department).
Randomized trial of abciximab with and without low-dose reteplase for acute myocardial infarction.
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576. Wong C-K, White HD, Wilcox RG, Criger DA, Califf RM, Topol EJ, Ohman EM, for the GUSTO-III
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GUSTO-III experience. American Heart Journal 140:878-885, 2000. [PMID 11099991]
577. Bhatt DL, Lincoff AM, Califf RM, Simoons ML, Tcheng JE, Brener SJ, Wolski KE, Topol EJ. The benefit
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578. Topol EJ. New platelet glycoprotein IIb/IIIa inhibitor trials in percutaneous coronary intervention. The
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646. Bittl JA, Chaitman BR, Feit F, Kimball W, Topol EJ. Bivalirudin versus heparin during coronary
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671. Park S-H, Marso SP, Zhou Z, Forudi F, Topol EJ, Lincoff AM. Neointimal hyperplasia following arterial
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672. Hudson MP, Granger CB, Topol EJ, Pieper KS, Armstrong PW, Barbash GI, Guerci AD, Vahanian A,
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673. Zhang R, Brennan M-L, Fu X, Aviles RJ, Pearce G, Penn MS, Topol EJ, Sprecher DL, Hazen SL.
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674. Bhatt DL, Topol EJ. PCI or CABG for multivessel disease? No clear winner in an unfair fight. Current
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675. Roffi M, Chew DP, Mukherjee D, Bhatt DL, White JA, Robbins MA, Moliterno DJ, Heeschen C, Hamm
CW, Califf RM, Harrington RA, White HD, Kleinman NS, Theroux P, Topol EJ. Platelet glycoprotein
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676. Bhatt DL, Kapadia SR, Bajzer CT, Chew DP, Ziada KM, Mukherjee D, Roffi M, Topol EJ, Yadav JS. Dual
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677. Ellis SG, Brener SJ, Lincoff AM, Moliterno DJ, Whitlow PL, Schneider JP, Topol EJ. Beta-blockers before
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Circulation 104:2685-2688, 2001. [PMID 11723019]
678. Topol EJ, McCarthy J, Gabriel S, Moliterno DJ, Rogers WJ, Newby LK, Freedom M, Metivier J, Cannata
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679. Chew DP, Bhatt DL, Topol EJ. Oral glycoprotein IIb/IIIa inhibitors: Why don't they work? American
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680. Boersma E, Harrington RA, Moliterno DJ, White H, Theroux P, Van de Werf F, de Torbal A, Pieper K,
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681. Zhou Z, Lauer MA, Wang K, Forudi F, Zhou X-R, Song X-Y, Kapadia SR, Nakada MT, Topol EJ, Lincoff
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682. Gibler WB, Armstrong PW, Ohman EM, Weaver WD, Stebbins AL, Gore JM, Newby LK, Califf RM, Topol
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683. Roe MT, Granger CB, Puma JA, Hellkamp AS, Hochman JS, Ohman EM, White HD, Van de Werf F,
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684. Brener SJ, Topol EJ. Epicardial versus microcirculatory dissociation. European Heart Journal 23:274-
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685. Labinaz M, Kilaru R, Pieper K, Marso SP, Kitt MM, Simoons ML, Califf RM, Topol EJ, Armstrong PW,
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and prior coronary artery bypass grafting: Results from the PURSUIT Trial. Circulation 105:322-327,
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686. Roffi M, Chew DP, Mukherjee D, Bhatt DL, White JA, Moliterno DJ, Heeschen C, Hamm CW, Robbins
MA, Kleiman NS, Theroux P, White HD, Topol EJ. Platelet glycoprotein IIb/IIIa inhibition in acute
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687. Casserly I, Topol EJ. Glycoprotein IIb/IIIa antagonists--From bench to practice. Cellular and Molecular
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688. Mukherjee D, Topol EJ. Pharmacogenomics in cardiovascular disease. Progress in Cardiovascular
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689. Brener SJ, Zeymer U, Adgey AJ, Vrobel TR, Ellis SG, Neuhaus K-L, Juran N, Ivanc TB, Ohman EM,
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690. Lewis D, Wang Q, Topol EJ. Ischaemic heart disease. Encyclopedia of Life Sciences Website:
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691. Gibler WB, Topol EJ, Holroyd B, Armstrong PW. Cardiology and emergency medicine: United we stand,
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692. Mahaffey KW, Harrington RA, Akkerhius M, Kleiman NS, Berdan LG, Crenshaw BS, Tardiff BE, Granger
CB, DeJong I, Bhapkar M, Widimsky P, Corbalon R, Lee KL, Deckers JW, Simoons ML, Topol EJ, Califf
RM, for the PURSUIT Investigators. Clinical events committee adjudication of myocardial infarction
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693. Chan AW, Chew DP, Bhatt DL, Moliterno DJ, Topol EJ, Ellis SG. Long-term mortality benefit with the
combination of stents and abciximab for cardiogenic shock complicating acute myocardial infarction: A 7
year prospective analysis. American Journal of Cardiology 89:132-136, 2002. [PMID 11792330]
694. Quinn MJ, Topol EJ. Common variations in platelet glycoproteins: pharmacogenomic implications.
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695. Mukherjee D, Nissen SE, Topol EJ. COX-2 inhibitors and cardiovascular risk: we defend our data and
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696. Anderson RD, White HD, Ohman EM, Wagner GS, Krucoff MW, Armstrong PW, Weaver WD, Gibler WB,
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144:81-8, 2002. [PMID 12094192]
697. Lauer MA, Karweit JA, Cascade EF, Lin ND, Topol EJ. Practice patterns and outcomes of percutaneous
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698. Chan AW, Bhatt DL, Chew DP, Quinn MJ, Moliterno DJ, Topol EJ, Ellis SG. Early and sustained survival
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105:691-96, 2002. [PMID 11839623]
699. Moliterno DJ, Topol EJ. TARGET (do Tirofiban And Reopro Give Similar Efficacy outcomes Trial) hit or
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700. Moliterno DJ, Yakubov SJ, DiBattiste PM, Herrmann HC, Stone GW, Macaya C, Neumann F-J, Ardissino
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701. Ellis SG, Lincoff AM, Whitlow PL, Raymond RE, Franco I, Schneider JP, Topol EJ. Evidence that
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702. HERO-2 Trial Investigators. Thrombin-specific anticoagulation with bivalirudin versus heparin in patients
receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 Trial. The Lancet 358:1855-63,
2001. [PMID 11741625]
703. Penn MS, Francis GS, Ellis SG, Young JB, McCarthy P, Topol EJ. Autologous cell transplantation for the
treatment of damaged myocardium. Progress in Cardiovascular Disease 45:21-32, 2002. [PMID
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704. Mahaffey KW, Roe MT, Dyke CK, Newby LK, Kleiman NS, Connolly P, Berdan LG, Sparapani R, Lee KL,
Armstrong PW, Topol EJ, Califf RM, Harrington RA, for the PARAGON-B Investigators. Misreporting of
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705. Mahaffey KW, Harrington RA, Akkerhius M, Kleiman NS, Berdan LG, Crenshaw BS, Tardiff BE, Granger
CB, DeJong I, Bhapkar M, Widimsky P, Corbalon R, Lee KL, Deckers JW, Simoons ML, Topol EJ, Califf
RM, for the PURSUIT Investigators. Systemic adjudication of myocardial infarction endpoints in an
international clinical trial. Current Controlled Trials in Cardiovascular Medicine 2:180-86, 2001.
706. Roffi M, Cattaneo F, Topol EJ. Thyrotoxicosis and the cardiovascular system. The Cleveland Clinic
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707. Cantor WJ, Newby LK, Christenson RH, Tuttle RH, Hasselblad V, Armstrong PW, Moliterno DJ, Califf RM,
Topol EJ, Ohman EM, for the SYMPHONY and 2nd SYMPHONY Cardiac Markers Substudy
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Journal of the American College of Cardiology 39:1738-44, 2002. [PMID 12039485]
708. Topol EJ, Lincoff AM, Kereiakes DJ, Kleiman NS, Cohen EA, Ferguson JJ, Tcheng JE, Califf RM, for the
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709. Lincoff AM, Kleiman NS, Kottke-Marchant K, Maierson ES, Maresh K, Wolski KE, Topol EJ. Bivalirudin
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710. Savonitto S, Granger CB, Ardissino D, Gardner L, Cavallini C, Galvani M, Ottani F, White HD, Armstrong
PW, Ohman EM, Pieper KS, Califf RM, Topol EJ, on behalf of the GUSTO-IIb Investigators. The
prognostic value of creatine kinase elevations extends across the whole spectrum of acute coronary
syndromes. Journal of the American College of Cardiology 39:22-29, 2002. [PMID 11755282]
711. Estess JM, Topol EJ. Fibrinolytic therapy for elderly patients with myocardial infarction. Heart 87:308-
311, 2002. [PMID 11906993]
712. The PARAGON-B Investigators. Randomized, placebo-controlled trial of titrated intravenous lamifiban for
acute coronary syndromes. Circulation 105:316-321, 2002. [PMID 11804986]
713. Jeremias A, Bhatt DL, Chew DP, Ziada KM, Albirini A, Brener SJ, Lincoff AM, Topol EJ, Ellis SG. Safety
of abciximab during percutaneous coronary intervention in patients with chronic renal insufficiency.
American Journal of Cardiology 89:1209-1211, 2002. [PMID 12008179]
714. Stone GW, Moliterno DJ, Bertrand M, Neumann F-J, Herrmann HC, Powers ER, Grines CL, Moses JW,
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different response to two glycoprotein IIb/IIIa inhibitors in patients undergoing coronary stenting: The
TARGET Trial. Circulation 105:2347-54, 2002. [PMID 12021219]
715. Gurm HS, Brennan DM, Booth J, Tcheng JE, Lincoff AM, Topol EJ. The obesity paradox, the impact of
body mass index on outcome after percutaneous coronary intervention. American Journal of Cardiology
90:42-45, 2002. [PMID 12088778]
716. Ellis SG, Schneider JP, Topol EJ. Comparison of long-term survival following non-Q-wave creatine
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MS, Topol EJ, Lincoff AM. Recombinant soluble P-selectin glycoprotein ligand-Ig (rPSGL-Ig) attenuates
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718. Al-Khatib SM, Granger CB, Huang Y, Lee KL, Califf RM, Simoons ML, White HD, Armstrong PW, Van de
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patients with acute coronary syndromes with no ST-segment elevation: Incidence, predictors, and
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719. Quinn MJ, Plow EF, Topol EJ. Platelet glycoprotein IIb/IIIa inhibitors: Recognition of a two-edged sword?
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720. Bhatt DL, Topol EJ. The need to test the arterial inflammation hypothesis. Circulation 106:136-40, 2002.
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721. Mazur W, Kaluza GL, Sapp S, Balog C, Topol EJ, Mark DB, Ellis SG, Kereiakes D, Lincoff AM, Kleiman
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722. Mukherjee D, Mahaffey KW, Moliterno DJ, Harrington RA, Yadav JS, Pieper KS, Gallup D, Dyke C, Roe
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American Heart Journal 144:995-1002, 2002. [PMID 12486423]
723. Ronner E, Boersma E, Laarman G-J, Somsen GA, Harrington RA, Deckers JW, Topol EJ, Califf RM,
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outcome, but increases need for 6 month repeat revascularization. An analysis of the PURSUIT-trial.
Journal of the American College of Cardiology 39:1924-29, 2002. [PMID 12084589]
724. Califf RM, Pieper KS, Lee KL, Van de Werf F, Simes RJ, Armstrong PW, Topol EJ. Prediction of 1-year
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A randomized multicenter trial comparing a new, low-pressure versus a conventional coronary stent:
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726. Wong C-K, White HD, Wilcox RG, Criger DA, Califf RM, Topol EJ, Ohman EM, for the GUSTO III
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infarction: The GUSTO-III Experience. Heart Journal 88:357-62, 2002. [PMID 12231591]
727. Roffi M, Moliterno DJ, Meier B, Powers ER, Grines CL, DiBattiste PM, Herrmann HC, Bertrand M, Harris
KA, Demopoulos LA, Topol EJ, for the TARGET Investigators. The impact of different platelet
glycoprotein IIb/IIIa receptor inhibitors among diabetic patients undergoing percutaneous coronary
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728. Yoon J, Wu C-J, Homme J, Tuch RJ, Wolff RG, Topol EJ, Lincoff AM. Local delivery of nitric oxide from
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729. Blankenship JC, Balog C, Sapp SK, Godfrey N, Califf RM, Lincoff AM, Tcheng JE, Topol EJ. Reduction
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730. Chan AW, Quinn MJ, Bhatt DL, Chew DP, Moliterno DJ, Topol EJ, Ellis SG. Mortality benefit of betablockade
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731. Al-Khatib SM, Stebbins AL, Califf RM, Lee KL, Granger CB, White HD, Armstrong PW, Topol EJ, Ohman
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732. Brener SJ, Ellis SG, Schneider J, Topol EJ. Frequency and long-term impact of myonecrosis after
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733. Dauterman K, Topol EJ. Optimal treatment and current situation in reperfusion after thrombolysis for
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734. Tamberella MR, Bhatt DL, Chew DP, Kereiakes DJ, Topol EJ, Steinhubl SR, on behalf of the GOLD
Investigators. Relation of platelet inactivation with intravenous glycoprotein IIb/IIIa antagonists to major
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736. Mehta RH, Criger DA, Granger CB, Califf RM, Topol EJ, Bates ER. Patient outcomes after fibrinolytic
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737. Jeremias A, Albirini A, Ziada KM, Chew DP, Brener SJ, Topol EJ, Ellis SG. Prognostic significance of
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738. Aviles RJ, Askari AT, Jia G, Ohman EM, Mahaffey KW, Newby LK, Berger PB, Califf RM, Lindahl B,
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739. Roffi M, Mukherjee D, Chew DP, Bhatt DL, Cho L, Robbins MA, Ziada KM, Brennan DM, Ellis SG, Topol
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740. Kottke-Marchant K, Bahit MC, Granger CB, Zoldhelyi P, Ardissino D, Zaramo C, Griffin JH, Pothoff RF,
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12, 2002. [PMID 12127922]
741. Robbins M, Topol EJ. Inflammation as the principal pathway to acute coronary syndromes. The
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742. Mukherjee D, Gurm H, Tang WHW, Roffi M, Wolski K, Moliterno DJ, Guetta V, Ardissino D, Bode C, Steg
G, Lincoff AM, Topol EJ. Outcome of acute myocardial infarction in patients with prior coronary artery
bypass surgery treated with combination reduced fibrinolytic therapy and abciximab. American Journal of
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743. Islam MA, Blankenship JC, Balog CA, Iliadis EA, Lincoff AM, Tcheng JE, Califf RM, Topol EJ, for the
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coronary intervention with stents in the EPISTENT Trial. American Journal of Cardiology 90:916-21,
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744. Zhou Z, Penn MS, Forudi F, Zhou X, Tarakji K, Topol EJ, Lincoff AM, Wang K. Administration of a
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745. Cho L, Bhatt DL, Marso SP, Brennan D, Holmes DR Jr., Califf RM, Topol EJ. An invasive strategy is
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747. Belch JJ, Topol EJ, Agnelli G, Bertrand M, Califf RM, Clement DL, Creager MA, Easton JD, Gavin III JR,
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748. Topol EJ. Economics and quality of care for patients with acute coronary syndromes: The impending
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749. Kereiakes DJ, Lincoff AM, Anderson KM, Achenbach R, Patel K, Barnathan E, Califf RM, Topol EJ, on
behalf of the EPIC, EPILOG, and EPISTENT Investigators. Abciximab survival advantage following
percutaneous coronary intervention is predicted by clinical risk profile. American Journal of Cardiology
90:628-630, 2002. [PMID 12231090]
750. Bhatt DL, Marso SP, Hirsch AT, Ringleb PA, Hacke W, Topol EJ. Amplified benefit of clopidogrel versus
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751. Cura FA, Kapadia SR, L'Allier PL, Ziada KM, Mukherjee D, Wolski KE, Yadav JS, Brener SJ, Whitlow PL,
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752. Ottervanger JP, Armstrong PW, Barnathan ES, Boersma E, Cooper JS, Ohman EM, James S, Topol EJ,
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inhibitor abciximab in unstable angina: 1-year survival in the GUSTO IV ACS Trial. Circulation 107:437-
442, 2003.
753. Mukherjee D, Topol EJ. COX-2: Where are we in 2003? Arthritis Research & Therapy, 5:8-11, 2003.
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754. Agah R, Topol EJ. Genetic testing for coronary heart disease: the approaching frontier. Expert Review
of Molecular Diagnostics 2:448-60, 2002. [PMID 12271816]
755. Casserly IP, Topol EJ. The primacy of clinical effectiveness for cost-effectiveness analysis. Heart
89:249-50, 2003. [PMID 12591818]
756. Steinhubl SR, Berger PB, Mann JT, Fry ETA, DeLargo A, Wilmer C, Topol EJ, for the CREDO
Investigators. Early and sustained dual oral antiplatelet therapy for percutaneous coronary intervention:
results of the Clopidogrel for the Reduction of Events During Observation (CREDO) Trial. Journal of the
American Medical Association 288:2411-20, 2002. [PMID 12435254]
757. Topol EJ. Aspirin with bypass surgery---from taboo to new standard of care. New England Journal of
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758. Brener SJ, Lytle BW, Schneider JP, Ellis SG, Topol EJ. Association between CK-MB elevation after
percutaneous or surgical revascularization and three-year mortality. Journal of the American College of
Cardiology 40:1961-67, 2002. [PMID 12475456]
759. Lincoff AM, Califf RM, van de Werf F, Willerson JT, White HD, Armstrong PW, Guetta V, Gibler WB,
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Booth JE, Wolski K, Waller M, Topol EJ, for the GUSTO V Investigators. Mortality at 1 year with
combination platelet glycoprotein IIb/IIIa inhibition and reduced-dose fibrinolytic therapy versus
conventional fibrinolytic therapy for acute myocardial infarction: the GUSTO V Randomized Trial. Journal
of the American Medical Association 288:2130-2135, 2002. [PMID 12413372]
760. Kaul P, Newby LK, Fu Y, Hasselblad V, Mahaffey KW, Christenson RH, Harrington RA, Ohman EM, Topol
EJ, Califf RM, Van de Werf F, Armstrong PW, for the PARAGON-B Investigators. Troponin T and
quantitative ST-segment depression offer complimentary prognostic information in the risk stratification of
acute coronary syndrome patients. Journal of the American College of Cardiology 41:371-80, 2003.
[PMID 12575962]
761. Gum PA, Kottke-Marchant K, Welsh PA, White J, Topol EJ. A prospective, blinded determination of the
natural history of aspirin resistance among stable patients with cardiovascular disease. Journal of the
American College of Cardiology 41:961-65, 2003. [PMID 12651041]
762. Cho L, Bhatt DL, Brennan D, Wilcox RG, Topol EJ. Relation of insurance status to performance of
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coronary angiography in patients with unstable angina pectoris or acute myocardial infarction. American
Journal of Cardiology 91:721-23, 2003. [PMID 12633807]
763. Newby LK, Harrington RA, Bhapkar MV, Hochman JS, Granger CB, Davis CG, Topol EJ, Simes RJ,
Califf RM, Van de Werf F, Moliterno DJ, for the PARAGON A Investigators. An automated strategy for
bedside aPTT determination and unfractionated heparin infusion adjustment in acute coronary
syndromes: Implications for clinical trials and clinical practice. Journal of Thrombosis and Thrombolysis
14:33-42, 2002. [PMID 12652148]
764. Lee MS, Wali AU, Menon V, Berkowitz SD, Thompson TD, Califf RM, Topol EJ, Granger CB, Hochman
JS. The determinants of activated partial thromboplastin time, relation of activated partial thromboplastin
time to clinical outcomes, and optimal dosing regimens for heparin treated patients with acute coronary
syndromes: a review of GUSTO-IIb. Journal of Thrombosis and Thrombolysis 14:91-101, 2002. [PMID
12714828]
765. Brener SJ, Ellis SG, Schneider J, Apperson-Hansen C, Topol EJ. Abciximab-facilitated percutaneous
coronary intervention and long-term survival - a prospective single-center registry. European Heart
Journal 24:630-38, 2003. [PMID 12657221]
766. Yen MH, Topol EJ. Atheromatous showers, periprocedural myocardial infarction, and fatality. American
Heart Journal 145:933-35, 2003. [PMID 12796744]
767. Topol EJ, Kereiakes DJ. Regionalization of care for ischemic heart disease: A call for specialized
centers. Circulation 107:1463-66, 2003. [PMID 12654599]
768. James S, Armstrong P, Barnathan E, Califf R, Lindahl B, Siegbahn A, Simoons M, Topol EJ, Wenge P,
Wallentin L, and the GUSTO-IV ACS Investigators. Troponin and C-reactive protein have different
relations to subsequent mortality and myocardial infarction after unstable coronary syndrome--a GUSTO-
IV Substudy. Journal of the American College of Cardiology 41:916-24, 2003. [PMID 12651034]
769. O'Shea JC, Wilcox RG. Skene AM, Stebbins AL, Granger CB, Armstrong PW, Bode C, Ardisssino D,
Emanuelsson H, Aylward PE, White HD, Sadowski Z, Topol EJ, Califf RM, Ohman EM. Comparison of
outcomes of patients with myocardial infarction when living alone versus those not living alone. American
Journal of Cardiology 90:1374-77, 2002. [PMID 12480048]
770. Wang K, Zhou X, Zhou Z, Tarakji K, Carneiro M, Penn MS, Murray D, Klein A, Humphries RG, Turner J,
Thomas JD, Topol EJ, Lincoff AM. Blockade of platelet P2Y12 receptor by AR-C69931MX sustains
coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis
model. Arteriosclerosis, Thrombosis and Vascular Biology 23:357-362, 2003. [PMID 12588784]
771. Bhatt DL, Topol EJ. Scientific and therapeutic advances in antiplatelet therapy. Nature Reviews Drug
Discovery, 2:15-28, 2003. [PMID 12509756]
772. Askari AT, Brennan M-L, Zhou X, Drinko J, Morehead A, Thomas JD, Topol EJ, Hazen SL, Penn MS.
Myeloperoxidase and plasminogen activator inhibitor-1 play a central role in ventricular remodeling after
myocardial infarction. Journal of Experimental Medicine 197:615-624, 2003. [PMID 12615902]
773. Mukherjee D, Topol EJ. Pharmaceutical advertising versus research spending: Are profits more
important than patients? American Heart Journal 146:563-64, 2003. [PMID 14564305]
774. Hasdai D, Topol EJ, Kilaru R, Battler A, Harrington RA, Vahanian A, Ohman EM, Granger CB, Van de
Werf F, Simoons ML, O'Connor CM, Holmes Jr DR. Frequency, patient characteristics and outcomes of
mild to moderate heart failure complicating ST-segment elevation acute myocardial infarction: Lessons
from 4 International Fibrinolytic Therapy Trials. American Heart Journal 145:73-79, 2003. [PMID
12514657]
775. Stenina OI, Krukovets I, Forudi F, Wang K, Penn M, Topol EJ, Plow EF. The increased expression of
thrombospondin-1 in the vessel wall of a diabetic Zucker rat. Circulation 107:3209-3215, 2003. [PMID
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776. You S-A, Archacki SR, Angheloiu G, Kinter M, Moravec CS, Topol EJ, Wang Q. Proteomic approach to
coronary atherosclerosis indicates ferritin light chain as a significant marker: Evidence to support the iron
hypothesis in atherosclerotic disease. Physiological Genomics 13:25-30, 2003. [PMID 12644631]
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Page 50

777. Zhou Z, Wang K, Penn MS, Marso SP, Lauer MA, Forudi F, Zhou X, Qu W, Lu Y, Stern DM, Schmidt AM,
Lincoff AM, Topol EJ. Receptor for AGE (RAGE) mediates neointimal formation in response to arterial
injury in diabetic rats. Circulation 107:2238-43, 2003. [PMID 12719284]
778. McCarthy JJ, Lehner T, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ, for the GeneQuest Investigators.
Association of genetic variants in the HDL receptor, SR-B1, with abnormal lipids in women with coronary
artery disease. Journal of Medical Genetics 40:453-458, 2003 [PMID 12807968]
779. Chan AW, Bhatt DL, Chew DP, Reginelli J, Schneider JP, Topol EJ, Ellis SG. Relation of inflammation
and benefit of statins following percutaneous coronary interventions. Circulation 107:1750-56, 2003.
[PMID 12665489]
780. Rao S, Li X, Guo Z, Moser KL, Topol EJ, Wang Q. An analysis-of-variance (ANOVA) approach for sibpair
linkage analysis of complex ordinal human diseases. Chinese Journal of Biomedical Engineering
11:104-112, 2002.
781. Breeman A, Mercado N, Lenzen M, van den Brand MMJ, Harrington RA, Califf RM, Topol EJ, Simoons
ML, Boersma E, for the PURSUIT Investigators. Characteristics, treatment and outcome of patients with
non-ST-elevation acute coronary syndromes and multivessel coronary artery disease: Observations from
PURSUIT. Cardiology 98:195-201, 2002. [PMID 12566649]
782. Lincoff AM, Bittl JA, Kleiman NS, Sarembock IJ, Jackman JD, Mehta S, Kereiakes DJ, Harrington RA,
Maierson EF, Chew DP, Topol EJ, for the REPLACE-1 Investigators. Bivalirudin and provisional
glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during
percutaneous coronary intervention: the randomized evaluation of PCI linking angiomax to reduced
clinical events (REPLACE) - 2 Trial. Journal of the American Medical Association 289:853-63, 2003.
[PMID 12588269]
783. Topol EJ. A guide to therapeutic decision-making in patients with non-ST-segment elevation acute
coronary syndromes. Journal of the American College of Cardiology 41:123S-129S, 2003. [PMID
12644350]
784. Gurm HS, Bhatt DL, Gupta R, Ellis SG, Topol EJ, Lauer MS. Impact of preprocedural white blood cell
count on long-term mortality after percutaneous coronary intervention: insights from the EPIC, EPILOG,
and EPISTENT trials. Heart 89:1200-4, 2003. [PMID 12975419]
785. Wang K, Kessler PD, Zhou Z, Penn MS, Forudi F, Zhou X, Tarakji K, Kibbe M, Kovesdi I, Brough DE,
Topol EJ, Lincoff AM. Local adenoviral-mediated inducible nitric oxide synthase (iNOS) gene transfer
inhibits neointimal formation in the porcine coronary stented model. Molecular Therapy 7:597-603, 2003.
[PMID 12718902]
786. Newby LK, Bhapkar MV, White HD, Topol EJ, Dougherty FC, Harrington RA, Smith MC, Asarch LF, Califf
RM, for the SYMPHONY and 2nd SYMPHONY Investigators. Predictors of 90 day outcome in patients
stabilized after acute coronary syndromes. European Heart Journal 24:172-182, 2003.
787. Ross MJ, Herrmann HC, Moliterno DJ, Blankenship JC, DiBattiste PM, Ellis SG, Frey MJ, Gazzal Z,
Martin JL, White J, Topol EJ. Angiographic variables predict increased risk for adverse ischemic events
following coronary stenting with glycoprotein IIb/IIIa inhibition: results from the TARGET Trial. Journal of
the American College of Cardiology 42:981-88, 2003. [PMID 13678916]
788. Cho L, Chew DP, Moliterno DJ, Roffi M, Ellis SG, Franco I, Bajzer C, Bhatt DL, Dorosti K, Simpfendorfer
C, Tuzcu M, Yadav JS, Brener S, Raymond R, Whitlow P, Topol EJ, Lincoff AM. Safe and efficacious use
of bivalirudin for percutaneous coronary intervention with adjunctive platelet glycoprotein IIb/IIIa receptor
inhibition. American Journal of Cardiology 91:742-43, 2003. [PMID 12633814]
789. Casserly IP, Topol EJ, Jia G, Lange RA, Hamm C, Meier B, DiBattiste PM, Lakkis N, Chew DP, Stone
GW, Cohen DJ, Moliterno DJ. Effect of abciximab and tirofiban on activated clotting time during
percutaneous intervention and its relation to clinical outcomes. American Journal of Cardiology 92:125-
29, 2003. [PMID 12860211]
790. James SK, Lindahl B, Siegbahn A, Stridsberg M, Venge P, Armstrong P, Barnathan ES, Califf RM, Topol
EJ, Simoons ML., Wallentin L. N-terminal pro brain natriuretic peptide and other risk-markers for the
separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary
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artery disease--a GUSTO IV Substudy. Circulation 108:275-281, 2003. [PMID 12847065]
791. Migrino RQ, Topol EJ. A matter of life and death? The Heart Protection Study and protection of clinical
trial participants. Controlled Clinical Trials 24:501-5, 2003. [PMID 14500049]
792. Topol EJ. Current status and future prospects for acute myocardial infarction. Circulation 108:III 6-13,
2003. [PMID 14605014]
793. Lauer MS, Topol EJ. Clinical trials: Multiple endpoints, and multiple lessons. Journal of the American
Medical Association 289:2575-77, 2003. [PMID 12759328]
794. Stenina OI, Desai S, Kight K, Janigro D, Topol EJ, Plow EF. Thrombospondin-4 and its variants:
Expression and differential effects on endothelial cells. Circulation 108:1514-19, 2003. [PMID
12952849]
795. Khadour FH, Fu Y, Chang WC, Ma X, Mark D, Granger CB, Topol EJ, Califf RM, Armstrong PW. Impact
of on-site cardiac interventional facilities on management and outcome of patients with acute coronary
syndromes. Canadian Journal of Cardiology 19:257-63, 2003. [PMID 12677281]
796. Quinn MJ, Byzova TV, Qin J, Topol EJ, Plow EF. Integrin alpha IIb beta-3 and its antagonism.
Arteriosclerosis, Thrombosis and Vascular Biology 23:945-952, 2003. [PMID 12637342]
797. Aronow HD, Novaro GM, Lauer MS, Brennan DM, Lincoff AM, Topol EJ, Kereiakes DJ, Nissen SE. Inhospital
initiation of lipid-lowering therapy following coronary intervention is the strongest predictor of
long-term utilization: A propensity analysis. Archives of Internal Medicine 163:2576-82, 2003. [PMID
14638557]
798. Brennan M-L, Penn MS, Van Lente F, Nambi V, Shishehbor MO, Aviles RJ, Goormastic M, Pepoy ML,
McErlean ES, Topol EJ, Nissen SE, Hazen SL. Prognostic value of myeloperoxidase in patients with
chest pain. New England Journal of Medicine 349:1595-604, 2003. [PMID 14573731]
799. Gurm HS, Bhatt DL, Gupta R, Ellis SG, Topol EJ, Lauer MS. Preprocedural white blood cell count and
death after percutaneous coronary intervention. American Heart Journal 146:692-98, 2003. [PMID
14564325]
800. Chan AW, Moliterno DJ, Berger PB, Stone GW, DiBattiste PM, Yakubov SL, Wolski K, Bhatt DL, Topol
EJ, for the TARGET Investigators. Triple antiplatelet therapy during percutaneous coronary intervention
is associated with improved outcomes including 1-year survival. Results from the do Tirofiban and
ReoPro Give similar Efficacy outcome Trial (TARGET). Journal of the American College of Cardiology
42:1188-95, 2003. [PMID 14522478]
801. Newby LK, Hasselblad V, Armstrong PW, Van de Werf F, Mark DB, White HD, Topol EJ, Califf RM.
Time-based risk assessment after myocardial infarction. Implications for timing of discharge and
applications to medical decision making. European Heart Journal 24:182-89, 2003. [PMID 12573275]
802. Saw J, Steinhubl SR, Berger PB, Kereiakes DJ, Serebruany VL, Brennan D, Topol EJ, for the CREDO
Investigators. Lack of adverse clopidogrel--atorvastatin clinical interaction from secondary analysis of a
randomized, placebo-controlled clopidogrel trial. Circulation 108:921-924, 2003. [PMID 12925453]
803. Savonitto S, Armstrong PW, Ardissino D, Lincoff AM, Jia G, Booth J, Sila CA, Terrosu P, White HD, Califf
RM, Topol EJ, for the GUSTO V Investigators. Risk of intracranial hemorrhage with combined fibrinolytic
and glycoprotein IIb/IIIa inhibitor therapy in acute myocardial infarction: dichotomous response as a
function of age in the GUSTO V trial. European Heart Journal 24:1807-1814, 2003. [PMID 14563339]
804. Yen MH, Bhatt DL, Chew DP, Harrington RA, Newby LK, Ardissino D, Van de Werf F, White JA, Moliterno
DJ, Topol EJ, for the PARAGON A Investigators. Association between admission white blood cell count
and 1 year mortality in patients with acute coronary syndromes. American Journal of Medicine 115:318-
21, 2003. [PMID 12967697]
805. Tolleson TR, Newby LK, Harrington RA, Bhapkar MV, Berger P, Moliterno DJ, White HD, Ohman EM,
Verheugt FWA, Van de Werf F, Topol EJ, Califf RM, for the SYMPHONY and 2nd SYMPHONY
Investigators. Frequency of stent thrombosis after acute coronary syndromes. American Journal of
Cardiology 92:330-333, 2003. [PMID 12888148]
806. Topol EJ, Easton D, Harrington RA, Amarenco P, Califf RM, Graffagnino C, Davis S, Diener H-C,
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Page 52

Ferguson J, Fitzgerald D, Granett J, Shuaib A, Koudstaal PJ, Theroux P, Van de Werf F, Sigmon K,
Willerson JT, on behalf of the BRAVO Investigators. Randomized, double-blind, placebo-controlled,
international trial of oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease. Circulation
108:399-406, 2003. [PMID 12874182]
807. Chiu JH, Topol EJ, Whitlow PL, Hsu AP, Tuzcu EM, Franco I, Moliterno DJ. Peripheral vascular disease
and 1-year mortality following percutaneous coronary revascularization. American Journal of Cardiology
92:582-83, 2003. [PMID 12943879]
808. Exaire JE, Dauerman HL, Topol EJ, Blankenship JC, Wolski K, Raymond RE, Cohen EA, Moliterno DJ,
for the TARGET Investigators. Triple antiplatelet therapy does not increase femoral access bleeding with
vascular closure devices. American Heart Journal 147:31-34, 2004. [PMID 14691415]
809. Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention
of cardiovascular disease: A meta-analysis of randomized trials. The Lancet 361:2017-23, 2003. [PMID
12814711]
810. Askari AT, Unzek S, Popovic ZB, Goldman CK, Forudi F, Kiedrowski M, Rovner A, Ellis SG, Thomas JT,
DiCorleto PE, Topol EJ, Penn MS. Effect of stromal cell-derived factor-1 mediates stem cell homing and
tissue regeneration in ischemic cardiomyopathy. The Lancet 362:697-703, 2003. [PMID 12957092]
811. Shishehbor MH, Bhatt DL, Topol EJ. Using C-reactive protein to assess cardiovascular disease risk.
Cleveland Clinic Journal of Medicine 70:634-640, 2003. [PMID 12882386]
812. Topol EJ, Neumann F-J, Montalescott G. A preferred reperfusion strategy for acute myocardial
infarction. Journal of the American College of Cardiology 42:1886-89, 2003. [PMID 14662246]
813. Bhatt DL, Chew DP, Lincoff AM, Simoons ML, Harrington RA, Ommen SR, Jia G, Topol EJ.
Revascularization attenuates the increased mortality associated with an elevated white blood cell count
in acute coronary syndromes. American Journal of Cardiology 92:136-40, 2003. [PMID 12860213]
814. Ellis K, Tcheng JE, Sapp S, Topol EJ, Lincoff AM. Mortality benefit of beta blockade in patients with
acute coronary syndromes undergoing coronary intervention. Pooled results from the EPIC, EPILOG,
EPISTENT, CAPTURE and RAPPORT trials. Journal of Interventional Cardiology 16:299-305, 2003.
[PMID 14562669]
815. Khot UN, Khot MB, Bajzer CT, Sapp SK, Ohman EM, Brener SJ, Ellis SG, Lincoff AM, Topol EJ.
Prevalence of conventional risk factors in patients with coronary heart disease. Journal of the American
Medical Association 290:898-904, 2003. [PMID 12928466]
816. Brener SJ, Lytle BW, Casserly I, Schneider JP, Topol EJ, Lauer MS. A propensity analysis of long-term
survival after surgical or percutaneous revascularization in high-risk patients with multivessel coronary
artery disease. Circulation 109:2290-95, 2004. [PMID 15117846]
817. Archacki SR, Angheloiu G, Tan FL, DiPaola N, Shen G-Q, Moravec C, Ellis S, Topol EJ, Wang Q.
Identification of new genes associated with coronary artery disease by expression profiling.
Physiological Genomics 15:65-74, 2003 [PMID 12902549]
818. L'Allier PL, Aronow HD, Cura FA, Bhatt DL, Albirini A, Schneider JP, Topol EJ, Ellis SG. Clopidogrel is
associated with better in-hospital and 30-day outcomes than ticlopidine after coronary stenting.
Canadian Journal of Cardiology 19:1041-46, 2003. [PMID 12915931]
819. Quinn MJ, Aronow HD, Califf RM, Bhatt DL, Sapp Shelly, Kleiman NS, Harrington RA, Kong DF, Kandzari
DE, Topol EJ. Aspirin dose and six-month outcome after an acute coronary syndrome. Journal of the
American College of Cardiology 43:972-78, 2004. [PMID 15028352]
820. Mukherjee D, Hsu A, Moliterno DJ, Lincoff AM, Goormastic M, Topol EJ. Percutaneous coronary
intervention in young adults: Risk factors for premature atherosclerosis and determinants of adverse
outcomes after revascularization. American Journal of Cardiology 92:1465-67, 2003. [PMID 14675589]
821. McCarthy JJ, Meyer J, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ, for the GeneQuest Investigators.
Evidence for substantial effect modification by gender in a large-scale genetic association study of the
metabolic syndrome. Human Genetics 114:87-98, 2003 [PMID 14557872]
822. Brener SJ, Bhatt DL, Moliterno DJ, Schneider JP, Ellis SG, Topol EJ. Revisiting optimal anticoagulation
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with unfractionated heparin during coronary stent implantation. American Journal of Cardiology 92:1468-
71, 2003. [PMID 14675590]
823. Khot UN, Jia G, Moliterno DJ, Lincoff AM, Khot MB, Harrington RA, Topol EJ. Prognostic importance of
physical examination for heart failure in non-ST-elevation acute coronary syndromes: The enduring value
of Killip classification. Journal of the American Medical Association 290:2174-2181, 2003. [PMID
14570953]
824. Kong DF, Hasselblad V, Harrington RA, White HD, Tcheng JE, Kandzari DE, Topol EJ, Califf RM. Metaanalysis
of survival with platelet glycoprotein IIb/IIIa antagonists for percutaneous coronary interventions.
American Journal of Cardiology 92:651-55, 2003. [PMID 12972100]
825. Gurm H, Lincoff AM, Lee D, Tang WHW, Jia G, Booth JE, Califf RM, Ohman EM, Van de Werf F,
Armstrong PW, Guetta V, Wilcox R, Topol EJ. Outcome of acute ST-segment elevation myocardial
infarction in diabetics treated with fibrinolytic or combination reduced fibrinolytic therapy and platelet
glycoprotein IIb/IIIa inhibition: Lessons from the GUSTO V trial. Journal of the American College of
Cardiology 43:542-48, 2004. [PMID 14975461]
826. Topol EJ, Lauer MS. The rudimentary phase of personalized medicine: Risk scores. Lancet 362:1776-
77, 2003. [PMID 14654312]
827. Roffi M, Topol EJ. Percutaneous coronary intervention in diabetic patients with non-ST-segment
elevation acute coronary syndromes. European Heart Journal 25:190-98, 2004. [PMID 14972418]
828. Brener SJ, Topol EJ. Adjunctive therapy for percutaneous revascularization in acute myocardial
infarction. Current Pharmaceutical Design 10:399-405, 2004. [PMID 14965201]
829. Bittl JA, Chew DP, Topol EJ, Kong DF, Califf RM: Meta-analysis of randomized trials of percutaneous
transluminal coronary angioplasty versus atherectomy, atherotomy or laser angioplasty. Journal of the
American College of Cardiology 43:936-942, 2004. [PMID 15028347]
830. Chiu JH, Bhatt DL, Ziada KM, Whitlow PL, Lincoff AM, Chew DP, Ellis SG, Topol EJ. Impact of female
sex on outcomes following percutaneous coronary intervention: A decade of progress. American Heart
Journal 148:998-1002, 2004. [PMID 15632884]
831. Lee DS, Bhatt DL, Moliterno DJ, Peacock WF, Ellis SG, Topol EJ. The combination of enoxaparin,
glycoprotein IIb/IIIa inhibitors and an early invasive approach in patients with acute coronary syndromes.
Journal of Invasive Cardiology 16:46-51, 2004. [PMID 14760188]
832. Kandzari DE, Granger CB, Simoons M, White HD, Simes J, Mahaffey KW, Gore J, Weaver WD,
Longstreth WT, Stebbins A, Lee KL, Califf RM, Topol EJ, for the GUSTO-I Investigators. Risk factors for
intracranial hemorrhage and nonhemorrhagic stroke after fibrinolytic therapy: A case-control study from
the GUSTO-I trial. Journal of the American College of Cardiology 93:458-61, 2004. [PMID 14969623]
833. Wang Q, Rao S, Shen G-Q, Li L, Moliterno D, Newby LK, Rogers WJ, Cannata R, Zirzow E, Elston RC,
Topol EJ. Premature myocardial infarction novel susceptibility locus on chromosome 1p34-36 identified
by genome-wide linkage analysis. American Journal of Human Genetics, 74:262-271, 2004 [PMID
14732905]
834. Wang L, Fan C, Topol SE, Topol EJ, Wang Q. Mutation of MEF2A in an inherited disorder with features
of coronary artery disease. Science 302:1578-81, 2003. [PMID 14645853]
835. Kramer JM, Newby LK, Chang W-C, Simes J, Van de Werf F, Granger CB, Lee KL, White HD, Bhapkar
MV, Piegas LS, Topol EJ, Califf RM, Armstrong PW, for the SYMPHONY and 2nd SYMPHONY
Investigators. International variation in the use of evidence-based medicines for acute coronary
syndromes: Insights from the SYMPHONY studies. European Heart Journal 24:2133-41, 2003. [PMID
14643274]
836. Askari, A.T., Unzek, S., Goldman, C.K., Kiedrowski, M., Forudi, F., Ellis, S.G., Thomas, J.D., Topol, E.J.,
DiCorleto, P.E., Penn, M.S. Cellular, but not direct adenoviral delivery of VEGF results in improved LV
function and neovascularization in dilated ischemic cardiomyopathy. Journal of the American College of
Cardiology 43:1908-1914, 2004. [PMID 15145120]
837. Wong CK, White HD, Wilcox RG, Criger DA, Califf RM, Topol EJ, Ohman EM. Significance of atrial
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Page 54

fibrillation during acute myocardial infarction, and its current management insights from the GUSTO-3
Trial. Cardiac Electrophysiology Review 7:201-207, 2003. [PMID 14739713]
838. Roe MT, Mahaffey KW, Kilaru R, Alexander JH, Harrington RA, Tardiff BE, Granger CB, Ohman EM,
Moliterno DJ, Lincoff AM, Armstrong PW, Akkerhuis M, Simoons ML, Van de Werf F, Califf RM, Topol EJ.
Creatine kinase-MB elevation after percutaneous coronary intervention predicts adverse outcomes in
patients with acute coronary syndromes. European Heart Journal 4:313-21, 2004. [PMID 14984920]
839. McCarthy JJ, Parker A, Moliterno DJ, Salem R, Wang Q, Plow EF, Rao S, She G-Q, Rogers WJ, Newby
LK, Cannata R, Glatt K, Topol EJ, for the GENEQUEST Investigators. Large-scale association analysis
for identification of genes underlying premature coronary heart disease: Cumulative perspective from
analysis of 111 candidate genes. Journal of Medical Genetics 41:334-41, 2004. [PMID 15121769]
840. Kaul P, Fu Y, Newby LK, Califf RM, Topol EJ, Aylward P, Granger CB, Van de Werf F, Mark DB,
Armstrong PW, for the VIGOUR Group. International differences in the evolution of early discharge after
acute myocardial infarction. Lancet 363:511-17, 2004. [PMID 14975612]
841. Rao S, Li L, Li X, Moser KL, Guo Z, Shen G, Zhang T, Cannata R, Zirzow E, Topol EJ, Wang Q. Genetic
linkage analysis of longitudinal hypertension phenotypes using three summary measures. BMC Genetics
4:S24, 2003. [PMID 14975092]
842. Guo Z, Rao S, Moser KL, Zhang T, Gong B, Shen G, Li L, Cannata R, Zirzow E, Topol EJ, Wang Q.
Multivariate sib-pair linkage analysis of longitudinal phenotypes by three stepwise analysis approaches.
BMC Genetics 4:S68, 2003. [PMID 14975136]
843. Agah R, Ellis S, Chase S, Henderson M, Mlady L, Li J, Tubbs R, Marchant K, Warshawsky I, Rouse C,
Hughes K, Welch P, Topol EJ. Creation of a genetic databank for cardiovascular association studies:
Genebank at the Cleveland Clinic Heart Center (GATC). American Heart Journal 150:500-506, 2005.
[PMID 16169331]
844. Li X, Rao S, Zhang T, Guo Z, Moser KL, Topol EJ. An ensemble method for gene discovery based on
DNA microarray data. Science in China 47:396-405, 2004. [PMID 15623151]
845. Wessel J, Topol EJ, Ji M, Meyer J, McCarthy JJ. Replication of the association between the
thrombospondin-4 A387P polymorphism and myocardial infarction: Importance of effect modification by
waist to hip ratio. American Heart Journal 147:905-909, 2004. [PMID 15131549]
846. Narizhneva NV, Byers-Ward VJ, Quinn MJ, Zidar FJ, Plow EF, Topol EJ, Byzova TV. Molecular and
functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated
with the risk of premature, familial myocardial infarction. Journal of Biological Chemistry 279:21651-57,
2004 [PMID 15007078]
847. Casserly IP, Topol EJ. Convergence of atherosclerosis and Alzheimer's disease: inflammation,
cholesterol, and unfolded proteins. Lancet 363:1139-1146, 2004. [PMID 15064035]
848. Maroo A, Topol EJ. The early history and development of thrombolysis in acute myocardial infarction.
Journal of Thrombosis and Haemostasis 2:1867-70, 2004. [PMID 15550011]
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852. Labinaz M, Mathias J, Pieper K, Granger CB, Lincoff AM, Moliterno DJ, Van de Werf F, Simes J, White
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Andresdottir M, Frigge ML, Samani NJ, Topol EJ, Kong A, Gudnason V, Hakonarson H, Gulcher JR,
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856. Stenina OI, Byzova TV, Adams JC, McCarthy JJ, Topol EJ, Plow EF. Coronary artery disease and the
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857. McGuire DK, Newby LK, Bhapkar MV, Moliterno DJ, Hochman JS, Klein WW, Weaver WD, Pfisterer M,
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861. Quinn MJ, Bhatt DL, Zidar F, Vivekananthan D, Chew DP, Ellis SG, Plow E, Topol EJ. Effect of
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865. Ellis SG, Armstrong P, Betriu A, Brodie B, Herrmann H, Montalescot G, Neumann F-J, Smith JJ, Topol
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868. Asher CR, Moliterno DJ, Bhapkar MV, McGuire DK, Rao SV, Holmes DR, Newby LK, Bates ER, Topol
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870. Lincoff AM, Kleiman NS, Kereiakes DJ, Feit F, Bittl JA, Jackman JD, Sarembock IJ, Cohen DJ, Spriggs D,
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875. Narizhneva NV, Podrez EA, Byers-Ward VJ, Topol EJ, Byzova TV. Thrombospondin-1 upregulates cell
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876. McCarthy JJ, Meyer J, Moliterno DJ, Newby K, Rogers WJ, Topol EJ, for the GeneQuest Investigators.
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877. Rao SV, Jollis JG, Harrington RA, Granger CB, Newby LK, Armstrong PW, Lindblad L, Pieper K, Topol
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879. Topol EJ, Falk GW. A coxib a day won't keep the doctor away. The Lancet 364:639-640, 2004 [PMID
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880. Penn MS, Zhang M, Deglurkar I, Topol EJ. Role of stem cell homing in myocardial regeneration.
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883. Jefferson BK, Foster JH, McCarthy JJ, Ginsburg G, Parker A, Kottke-Marchant K, Topol EJ. Aspirin
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884. Topol EJ. Failing the public health--rofecoxib, Merck, and the FDA. New England Journal of Medicine
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885. Gurm HS, Topol EJ. The electrocardiogram in acute coronary syndromes--new tricks from an old dog.
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886. Gurm HS, Rajagopal V, Fathi R, Vivekanathan D, Yadav JS, Bhatt DL, Ellis G, Lincoff AM, Topol EJ.
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887. Nissen SE, Tuzcu EM, Libby P, Thompson PD, Ghali M, Garza D, Berman L, Shi H, Buebendorf E, Topol
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patients with coronary disease and normal blood pressure. The CAMELOT Study: A randomized
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888. Chan AW, Yadav JS, Bhatt DL, Bajzer CT, Roffi M, Cho L, Agah R, Topol EJ, Comparison of the safety
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889. Nallamothu BK, Bates ER, Hochman JS, Granger CB, Guetta V, Wilcox RG, White HD, Armstrong PW,
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890. Jefferson BK, Topol EJ. Molecular mechanisms of myocardial infarction. Current Problems in
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891. Karha J, Topol EJ. The sad story of vioxx and what we should learn from it. Cleveland Clinic Journal of
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892. Guo Z, Zhang T, Li X, Xu J, Wang Q, Yu H, Zhu J, Wang H, Topol EJ, Wang Q, Rao S. Towards precise
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893. Serebruany VL, Steinhubl SR, Berger PB, Malinin AI, Oshrine BR, Baggish JS, Bhatt DL, Topol EJ. The
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894. Topol EJ. Arthritis medicines and cardiovascular events--"House of Coxibs". Journal of the American
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895. Topol EJ. Cholesterol, racial variation, and targeted cardiovascular medicine. Nature Medicine, 11:122-
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896. Wang K, Tarakji K, Zhou Z, Zhang M, Forudi F, Zhou X, Koki AT, Smith ME, Keller BT, Topol EJ, Lincoff
AM, Penn MS. Celecoxib, a selective cyclooxygenase-2 inhibitor, decreases monocyte chemoattractant
protein-1 expression and neointimal hyperplasia in the rabbit atherosclerotic balloon injury model.
Journal of Cardiovascular Pharmacology 45:61-67, 2005 [PMID 15613981]
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Circulation 112:906-15; discussion 923, 2005 [PMID 160877811]
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dual oral antiplatelet therapy with clopidogrel following percutaneous coronary intervention: Results from
CREDO. Journal of the American College of Cardiology 46:761-69, 2005
899. Chew DP, Lincoff AM, Gurm H, Wolski K, Cohen DJ, Henry T, Berger P, Feit F, Topol EJ, for the
REPLACE-2 Trial. Bivalirudin versus heparin and glycoprotein IIb/IIIa inhibition among patients with renal
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American Journal of Cardiology 95:581-585, 2005 [PMID 15721095]
900. Rebeiz AG, Johanson P, Green CL, Crater SW, Roe MT, Langer A, Giugliano RP, Lincoff AM, Newby LK,
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Einarsson A, Gudmundsdottir H, Gudmundsson K, Thjodleifsson B, Adalsteinsdottir AE, Gudmundsson K,
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J, Kong A, Gurney M, Thorgeirsson G, Stefansson K. Effect of a 5-lipoxygenase activating protein
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904. Wang TH, Bhatt DL, Topol EJ. Aspirin and clopidogrel resistance: An emerging clinical entity. European
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905. Salpeter SR, Gregor P, Ormiston TM, Whitlock R, Raina R, Thebane L, Topol EJ. Meta-Analysis:
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906. Meine TJ, Al-Khatib SM, Alexander JH, Granger CB, White HD, Kilaru R, Williams K, Ohman EM, Topol
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907. Vasilyev N, Williams T, Brennan M-L, Unzek S, Zhou X, Heinecke JW, Spitz DR, Topol EJ, Hazen SL,
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908. Topol EJ, Blumenthal D. Physicians and the investment industry. Journal of the American Medical
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909. Savonitto S, Cohen MG, Politi A, Hudson MP, Granger CB, Kong DF, Huang Y, Pieper KS, Mauri F,
Wagner GS, Califf RM, Topol EJ. The extent of ST-segment depression on the admission
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European Heart Journal 26:2106-2113, 2005 [PMID 15987706]
910. Berger PB, Best PJ, Topol EJ, White J, DiBattiste PM, Chan AW, Kristensen SD, Herrmann HC,
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coronary intervention in patients with diabetes mellitus: An analysis from the Randomized Evaluation in
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918. Pluskota E, Stenina OI, Krukovets I, Szpak D, Topol EJ, Plow EF. The mechanisms and impact of TSP-4
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920. Chen MS, Bhatt DL, Chew DP, Moliterno DJ, Ellis SG, Topol EJ. Outcomes in African Americans and
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921. Bhatt DL, Fox KA, Hacke W, Berger PB, Black HR, Boden WE, Cacoub P, Cohen E, Creager MA, Easton
JD, Flather M, Haffner SM, Hamm CW, Hankey GJ, Johnson SC, Mak K-H, Mas J-L, Montalescot G,
Pearson TA, Steg PG, Steinhubl SR, Weber M, Booth J, Topol EJ, on behalf of the CHARISMA
Investigators. A global view of atherothrombosis: Baseline characteristics in the Clopidogrel for High
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922. Galla JM, Mahaffey KW, Sapp SK, Alexander JH, Roe MT, Ohman EM, Granger CB, Armstrong PW,
Harrington RA, White HD, Simoons ML, Newby LK, Califf RM, Topol EJ. Elevated creatine-kinase-MB
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934. Bushnell CD, Griffin J, Newby LK, Goldstein LB, Mahaffey KW, Graffagnino CA, Harrington RA, White
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surface area in humans in two independent populations. Proceedings of the National Academy of
Sciences 106(36):15483-15488, 2009. [PMID 19717458]
1025. Berger JS, Elliott L, Gallup D, Roe M, Granger CB, Armstrong PW, Simes RJ, White HD, Van de Werf F,
Topol EJ, Hochman JS, Newby LK, Harrington RA, Califf RM, Becker RC, Douglas PS. Sex
Differences in Mortality Following Acute Coronary Syndromes. Journal of the American Medical
Association 302:874-882, 2009. [PMID 19706861]
1026. Berger JS, Bhatt DL, Cannon CP, Chen Z, Jiang L, Jones JB, Mehta SR, Sabatine MS, Steinhubl SR,
Topol EJ, Berger PB. The Relative Efficacy and Safety of Clopidogrel in Women and Men: A Sex-
Specific Collaborative Meta-Analysis. Journal of the American College of Cardiology 54(21):1935-1945,
2009. [PMID 19909874]
1027. Valgimigli M, Biondi-Zoccai G, Tebaldi M, van 't Hof AW, Campo G, Hamm C, Ten Berg J, Bolognese L,
Saia F, Danzi GB, Briguori C, Okmen E, King SB, Moliterno DJ, Topol EJ. Tirofiban as adjunctive
therapy for acute coronary syndromes and percutaneous coronary intervention: a meta-analysis of
randomized trials. European Heart Journal 2009 Sep 14 (Epub ahead of print) [PMID: 19755402]
1028. Topol, EJ. How Genomic Medicine Will Affect the Future of Healthcare. Futurescan 2010: American
College of Healthcare Executives (In press, Jan 2010)
1029. Berger JS, Bhatt DL, Steinhubl SR, Shao M, Steg PG, Montalescot G, Hacke W, Fox KA, Lincoff AM,
Topol EJ, Berger PB, for the CHARISMA Investigators. Smoking, Clopidogrel, and Mortality in Patients
with Established Cardiovascular Disease. Circulation 120(23):2337-2344, 2009. [PMID 19933933]
1030. Schork NJ, Topol EJ. Genotype-Based Risk and Pharmacogenetic sampling in clinical trials. Journal of
Biopharmaceutical Statistics 20(2):315-333, 2010. [PMID 20309761]
1031. Tewhey R, Nakano M, Wang X, Pabón-Peña C, Novak B, Giuffre A, Lin E, Happe S, Roberts DN,
LeProust EM, Topol EJ, Harismendy O, Frazer KA. Enrichment of sequencing targets from the human
genome by solution hybridization. Genome Biology 10(10):R116, 2009. [PMID 19835619]
1032. Ellis SG, Tendera M, de Belder MA, can Boven AJ, Widimsky P, Anderson HR, Betriu A, Savonitto S,
Adamus J, Peruga JZ, Hamankiewicz M, Pluta W, Oldroyd K, Ecollan P, Janssens L, Armstrong P,
Brodie BR, Hermann HC, Montalescot G, Neumann FJ, Effron MB, Barnathan ES, Topol EJ; FINESSE
Investigators. 1-year survival in a randomized trial of facilitated reperfusion: results from the FINESSE
(Facilitated Intervention with Enhanced Reperfusion Speed to Stop Events) trial. Journal of the
American College of Cardiology, Cardiovascular Interventions 2(10):909-916, 2009. [PMID 19850248]
1033. Hermann HC, Lu J, Brodie BR, Armstrong PW, Montalescot G, Betriu A, Neuman FJ, Effron MB,
Barnathan ES, Topol EJ, Ellis SG; FINESSE Investigators. Benefit of facilitated percutaneous coronary
intervention in high-risk ST-segment elevation myocardial infarction patients presenting to
nonpercutaneous coronary intervention hospitals. Journal of the American College of Cardiology,
Cardiovascular Interventions 2(10):917-924, 2009. [PMID 19850249]
1034. Tewhey R, Warner JB, Nakano M, Libby B, Medkova M, David PH, Kotsopoulos SK, Samuels ML,
Hutchison JB, Larson JW, Topol EJ, Weiner MP, Harismendy O, Olson J, Link DR, Frazer KA.
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Page 67

Microdroplet-based PCR enrichment for large-scale targeted sequencing. Nature Biotechnology
27(11):1025-1031, 2009. [PMID 19881494]
1035. Dosh K, Berger PB, Marso S, van Lente F, Brennan DM, Charnigo R, Topol EJ, Steinhubl S.
Relationship between baseline inflammatory markers, antiplatelet therapy, and adverse cardiac events
after percutaneous coronary intervention: an analysis from the clopidogrel for the reduction of events
during observation trial. Circ. Cardiovasc. Interv. 2(6):503-512, 2009. [PMID 20031767]
1036. Yang R, Li L, Seidelmann SB, Shen GQ, Sharma S, Rao S, Abdullah KG, Mackinlay KG, Elston RC,
Chen Q, Topol EJ, Wang QK. A genome-wide linkage scan identifies multiple QTLs for HDL cholesterol
levels in families with premature CAD and MI. Journal of Lipid Research 51(6):1446-1451, 2010. [PMID
20075193]
1037. Montalescot G, Ellis SG, de Belder MA, Janssens L, Katz O, Pluta W, Ecollan P, Tendera M, van Boven
AJ, Widimsky P, Andersen HR, Betriu A, Armstrong P, Brodie BR, Hermann HC, Neumann FJ, Effron
MB, Lu J, Barnathan ES, Topol EJ, FINESSE Investigators. Enoxaparin in primary and facilitated
percutaneous coronary intervention A formal prospective nonrandomized substudy of the FINESSE trial
(Facilitated INtervention with Enhanced Reperfusion Speed to Stop Events). Journal of the American
College of Cardiology, Cardiovascular Interventions 3(2):203-212, 2010. [PMID 20170878]
1038. Schork NJ, Topol EJ. Genotype-based risk and pharmacogenetic sampling in clinical trials. Journal of
Biopharmaceutical Statistics 20(2):315-33, 2010. [PMID 20309761]
1039. Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PW, Mueller
M, Lubitz SA, Fox E, Darbar D, Smith NL, Smith JD, Schnabel RB, Soliman EZ, Rice KM, Van Wagoner
DR, Beckmann B-M, van Noord C, Wang K, Ehret GB, Rotter JI, Hazen S, Steinbeck G, Smith AV,
Launer LJ, Harris TB, Makino S, Nelis M, Milan DJ, Perz S, Esko T, Köttgen A, Moebus S, Newton-
Cheh C, Li M, Möhlenkamp S, Wang TJ, Kao WHL, Vasan RS, Nöthen M, MacRae CA, Stricker BHCh,
Hofman A, Uitterlinden AG, Levy D, Boerwinkle E, Metspalu A, Topol EJ, Chakravarti A, Gudnason V,
Psaty BM, Roden DM, Meitinger T, Wichmann H-E, Witteman JCM, Barnard J, Arking DE, Benjamin EJ,
Heckbert SR, Kääb S. Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation. Nature
Genetics 42(3):240-244, 2010. [PMID 20173747]
1040. Bansal V, Harismendy O, Tewhey R, Murray SS, Schork NJ, Topol EJ, Frazer KA. Accurate detection
and genotyping of SNPs utilizing population sequencing data. Genome Research 20(4):537-545, 2010.
[PMID 20150320]
1041. Damani S, Topol EJ. The Case for Routine Genotyping in Dual Antiplatelet Therapy. Journal of the
American College of Cardiology 56(2):109-111, 2010. [PMID 20471193]
1042. Topol, EJ. Transforming Medicine via Digital Innovation. Science Translational Medicine 2(16):16cm4,
2010. [PMID 20371472]
1043. Topol EJ. “Health Policy: The consumer movement in health care” Pharos Alpha Omega Alpha Honor
Med Soc. 73(2):34-5, Spring 2010. [PMID 20455379]
1044. Berger PB, Bhatt DL, Fuster V, Steg PG, Fox KA, Shao M, Brennan DM, Hacke W, Montalescot G,
Steinhubl SR, Topol EJ; CHARISMA Investigators. Bleeding complications with dual antiplatelet
therapy among patients with stable vascular disease or risk factors for vascular disease: results from
the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and
Avoidance (CHARISMA) trial. Circulation 121(23):2575-2583, 2010. [PMID 20516378]
1045. Hankey GJ, Hacke W, Easton JD, Johnston SC, Mas JL, Brennan DM, Bhatt DL, Fox KA, Topol EJ;
CHARISMA Trial Investigators. Effect of clopidogrel on the rate and functional severity of stroke among
high vascular risk patients: a prespecified substudy of the Clopidogrel for High Atherothrombotic Risk
and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial. Stroke 41(8):1679-1683,
2010. [PMID 20595658]
1046. Topol EJ. Pharmacy benefit managers, pharmacies, and pharmacogenomic testing: prescription for
progress? Science Translational Medicine 2(44):44cm22, 2010. [PMID 20702854]
1047. Topol EJ, Bousser MG, Fox KA, Creager MA, Despres JP, Easton JD, Hamm CW, Montalescot G,
Steg PG, Pearson TA, Cohen E, Gaudin C, Job B, Murphy JH, Bhatt DL; for The CRESCENDO
Investigators. Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised,
Bibliography | Eric J. Topol, M.D. | June 2011
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multicentre, placebo-controlled trial. The Lancet 376(9740):517-523, 2010. [PMID 20709233]
1048. Bloss CS, Ornowski L, Silver E, Cargill M, Vanier V, Schork NJ, Topol EJ. Consumer perceptions of
direct-to-consumer personalized genomic risk assessments. Genetics in Medicine 12(9):556-566, 2010.
[PMID 20717041]
1049. Damani SB, Topol EJ. Emerging clinical applications in cardiovascular pharmacogenomics. Wiley
Interdisciplinary Reviews-Systems Biology Medicine 2010 Aug 20, ePub ahead of print. [PMID
20730785]
1050. Smith EN, Chen W, Kahonen M, Kettunen J, Lehtimaki T, Peltonen L, Raitakari OT, Salem RM, Schork
NJ, Shaw M, Srinivasan SR, Topol EJ, Viikari JS, Berenson GS, Murray SS. PLoS Genetics 6(9):pii:
e1001094, 2010. [PMID 20838585]
1051. Topol EJ, Damani SB. The KIF6 Collapse. Journal of the American College of Cardiology 56(19):1564-
1566, 2010. [PMID 20888161]
1052. Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, Tingley WG, Sager PT, Sehnert AJ,
Yau M, Kraus WE, Newby LK, Schwartz RS, Voros S, Ellis SG, Tahirkheli N, Waksman R, McPherson
J, Lansky A, Winn ME, Schork NJ, Topol EJ; PREDICT (Personalized Risk Evaluation and Diagnosis in
the Coronary Tree) Investigators. Multicenter validation of the diagnostic accuracy of a blood-based
gene expression test for assesing coronary artery disease in nondiabetic patients. Annals of Internal
Medicine 153(7):425-434, 2010. [PMID 20921541]
1053. Tackett AH, Bailey AL, Foody JM, Miller JM, Apperson-Hansen C, Ohman EM, Hochman JS, Karnash
SL, Califf RM, Topol EJ, Moliterno DJ. Hormone replacement therapy among postmenopausal women
presenting with acute myocardial infarction: Insights from the GUSTO-III trial. American Heart Journal
160(4):678-684, 2010. [PMID 20934562]
1054. Barker CM, Murray SS, Teirstein PS, Kandzari DE, Topol EJ, Price MJ. Pilot study of the antiplatelet
effect of increased clopidogrel maintenance dosing and its relationship to CYP2C19 genotype in
patients with high on-treatment reactivity. Journal of the American College of Cardiology,
Cardiovascular Interventions 33(10):1001-1007, 2010. [PMID 20965456]
1055. Bhatia G, Bansal V, Harismendy O, Schork NJ, Topol EJ, Frazer K, Bafna V. A covering method for
detecting genetic associations between rare variants and common phenotypes. PLoS Comput Biol.
6(10):e1000954, 2010. [PMID 20976246]
1056. Harismendy O, Bansal V, Bhatia G, Nakano M, Scott M, Wang X, Dib C, Turlotte E, Sipe JC, Murray
SS, Deleuze JF, Bafna V, Topol EJ, Frazer KA. Population sequencing of two endocannabinoid
metabolic genes identifies rare and common regulatory variants associated with extreme obesity and
metabolite level. Genome Biology 11(11):R118, 2010. [PMID 21118518]
1057. Hankey GJ, Johnston SC, Easton JD, Hacke W, Mas JL, Brennan D, Mak KH, Bhatt DL, Fox KA, Topol
EJ; CHARISMA trial investigators. Effect of clopidogrel plus ASA vs. ASA early after TIA and ischaemic
stroke: a substudy of the CHARISMA trial. Int J Stroke 6(1):3-9, 2011. [PMID 21205234]
1058. Mehta RH, O'Shea JC, Stebbins AL, Granger CB, Armstrong PW, White HD, Topol EJ, Califf RM,
Ohman EM. Association of Mortality With Years of Education in Patients With ST-Segment Elevation
Myocardial Infarction Treated With Fibrinolysis. Journal of the American College of Cardiology
57(2):138-146, 2011. [PMID 21211684]
1059. Topol EJ, Schork NJ. Catapulting clopidogrel pharmacogenomics forward. Nature Medicine 17(1):40-
41, 2011. [PMID 21217678]
1060. Bansal V, Tewhey R, Topol EJ, Schork NJ. The next phase in human genetics. Nature Biotechnology
29(1):38-39, 2011. [PMID 21221098]
1061. Bloss CS, Schork NJ, Topol EJ. Effect of Direct-to-Consumer Genomewide Profiling to Assess
Disease Risk. New England Journal of Medicine 364(6):524-534, 2011. [PMID 21226570]
1062. Harismendy O, Notani D, Song X, Rahim NG, Tanasa B, Heintzman N, Ren B, Fu X-D, Topol EJ,
Rosenfeld MG, Frazer KA. 9p21 DNAvariants associated with coronary artery disease impair interferonc
signalling response. Nature 470(7333):264-268, 2011. [PMID 21307941]
1063. Tewhey R, Bansal V, Torkamani A, Topol EJ, Schork NJ. The importance of phase information for
Bibliography | Eric J. Topol, M.D. | June 2011
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human genomics. Nature Reviews Genetics 12(3):215-223, 2011. [PMID 21301473]
1064. Topol EJ, Schork NJ, Smith JM. Digital Medicine and the Scripps Translational Science Institute.
Clinical and Translational Science 4(1):8-9, 2011. [PMID 21348949]
1065. Weber M, Bhatt DL, Brennan DM, Hankey GJ, Steinhubl SR, Johnston SC, Montalescot G, Mak KH,
Easton DJ, Topol EJ, Hamm CW; for the CHARISMA Investigators. High-sensitivity C-reactive protein
and clopidogrel treatment in patients at high risk of cardiovascular events: a substudy from the
CHARISMA trial. Heart 97(8):626-631, 2011. [PMID 21393433]
1066. Price MJ, Berger PB, Teirstein PS, Tanguay JF, Angiolillo DJ, Spriggs D, Puri S, Robbins M, Garratt
KN, Bertrand OF, Stillablower ME, Aragon JR, Kandzari DE, Stinis CT, Lee MS, Manoukian SV,
Cannon CP, Schork NJ, Topol EJ; GRAVITAS Investigators. Standard- vs high-dose clopidogrel based
on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial.
Journal of the American Medical Association 305(11):1097-1105, 2011. [PMID 21406646]
1067. Elashoff MR, Wingrove JA, Beineke P, Daniels SE, Tingley WG, Rosenberg S, Voros S, Kraus WE,
Ginsburg GS, Schwartz RS, Ellis SG, Tahirkheli N, Waksman R, McPherson J, Lansky AJ, Topol EJ.
Development of a blood-based gene expression algorithm for assessment of obstructive coronary
artery disease in non-diabetic patients. BMC Med Genomics 4(1):26, 2011. [PMID 21443790]
1068. Chen J, Shi C, Mahoney EM, Dunn ES, Rinfret S, Caro JJ, O'Brien J, El-Hadi W, Bhatt DL, Topol EJ,
Cohen DJ. Economic Evaluation of Clopidogrel Plus Aspirin for Secondary Prevention of
Cardiovascular Events in Canada for Patients With Established Cardiovascular Disease: Results From
the CHARISMA Trial. Can J Cardiol 27(2):222-231, 2011. [PMID 21459271]
1069. Damani SB, Topol EJ. Emerging genomic applications in coronary artery disease. Journal of the
American College of Cardiology, Cardiovascular Interventions 4(5):473-482, 2011. [PMID 21596318]
Profiles
1. Emma Wilkinson. From Mechanics to Genetics in Cardiology. European Heart Journal 30.2291-93, 2009.
2. Daniel S. Levine. Lost in Translation. The Journal of Life Sciences, Fall 2009.
3. Elaine Musgrave, Ph.D. Exciting Interventions in Individualized Medicine – An Interview with Eric J. Topol,
MD of the Scripps Translational Science Institute. Clinical and Translational Science, 2(6):392-393, 2009.
[PMID 20443929]
4. Price Waterhouse Coopers’ Health Research Institute, Healthcare unwired: New business models
delivering care anywhere, September 2010.
Consumer/Public Editorials/Op-Eds
1. Topol EJ. “Good riddance to a bad drug.” New York Times, A27, October 2, 2004.
2. Topol EJ. “How not to do a clinical trial.” Forbes Magazine, October 4, 2004.
3. Topol EJ. “COX-2 Inhibitors: Safety Trials Needed.” Wall Street Journal, July 30, 2002.
4. Topol EJ. “Shotgun medicine.” Los Angeles Times, A21, March 28, 2007.
5. Topol EJ. “What You Can Learn From a Gene Scan.” Wall Street Journal, A10, December 22, 2007.
6. Topol EJ. “The Case for Putting Genomic Medicine to Work” San Diego Union Tribune, August 16, 2010.
7. Topol EJ. “Drugstore Geneticist” Project Syndicate, Sweden August 2010.
Consumer Books
1. Topol EJ, Digitizing Man, Basic Books/Perseus, New York, 2011.
Bibliography | Eric J. Topol, M.D. | June 2011
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Collaborative Group "Silent" Authored Papers
1. Participants in the National Heart, Lung, and Blood Institute Conference on the Evaluation of Emerging
Coronary Revascularization Technologies: Evaluation of emerging technologies for coronary
revascularization. Circulation 85:357-361, 1992.
2. Protocol for the bypass angioplasty revascularization investigation: The BARI –Protocol. Circulation
84:V1-V27, 1991.
3. Tommaso CL, Vogel JHK, Vogel RA for the National Registry of Elective Supported Angioplasty: Coronary
angioplasty in high-risk patients with left main coronary stenosis. Catheterization and Cardiovascular
Diagnosis 25:169-173, 1992.
4. The LATE Steering Committee: Late assessment of thrombolytic efficacy with alteplase 6-24 hours after
onset of acute myocardial infarction. The Lancet 342:759-766, 1993.
5. Fibrinolytic Therapy Trialists’ (FTT) Collaborative Group: Indications for fibrinolytic therapy in suspected
acute myocardial infarction: collaborative overview of mortality and major morbidity results from all
randomized trials of more than 1,000 patients. The Lancet 343:311-322, 1994.
6. The GUSTO Angiographic Investigators: The comparative effects of tissue plas-minogen activator,
streptokinase, or both on coronary artery patency, ventricular function, and survival after acute
myocardial infarction. New England Journal of Medicine 329:1615-1622, 1993.
7. The GUSTO Investigators: An international randomized trial comparing four thrombolytic strategies for
acute myocardial infarction. New England Journal of Medicine 329:673-682, 1993.
8. National Heart Attack Alert Program Coordinating Committee 60 Minutes to Treatment Working Group:
Rapid identification and treatment of acute myocardial infarction in the emergency department. Annals of
Emergency Medicine 23(2): 311-329, 1994.
9. Cardiac Catheterization Committee. Bethesda Conference 17: Adult Cardiology Training Task Force III:
Training in Cardiac Catheterization. Journal of the -American College of Cardiology 22(2): 629-31, 1993.
10. The EPIC Investigators: Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa
receptor in high-risk coronary angioplasty. New England Journal of Medicine 330:956-961, 1994.
11. Michels KB, Yusuf S: Does PTCA in acute myocardial infarction affect mortality and reinfarction rates?
Circulation 91:476-485, 1995.
12. The GUSTO IIa Investigators. Randomized trial of intravenous heparin versus recombinant hirudin for
acute coronary syndromes. Circulation 90:1631-1637, 1994.
13. The BARI Investigators. The Bypass Angioplasty Revascularization Investigation (BARI): Comparison of
coronary bypass surgery with angioplasty in patients with multivessel disease. The New England Journal
of Medicine 335:217-225, 1996.
14. The Global Utilization of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators. A
comparison of recombinant hirudin versus heparin for the treatment of acute coronary syndromes. New
England Journal of Medicine 335:775-782, 1996.
15. The IMPACT II Investigators. Randomized placebo-controlled trial of effect of eptifibatide on
complications of percutaneous coronary intervention. The Lancet 349:1422-1428, 1997.
16. The GUSTO II Angioplasty Substudy Investigators. A clinical trial comparing primary coronary
angioplasty with tissue plasminogen activator for acute myocardial infarction. New England Journal of
Medicine 336:1621-28, 1997.
17. CAPRIE Investigators. A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of
ischemic events (CAPRIE). The Lancet 348:1329-1339, 1996.
18. EPILOG Investigators. Effect of the platelet glycoprotein IIb/IIIa receptor inhibitor abciximab with lower
heparin dosages on ischemic complications of percutaneous coronary revascularization. New England
Journal of Medicine 336:1689-96, 1997.
19. The Writing Group for the Bypass Angioplasty Revascularization Investigation (BARI) Investigators. Five-
Bibliography | Eric J. Topol, M.D. | June 2011
Page 71

year clinical and functional outcome comparing bypass surgery and angioplasty in patients with
multivessel coronary disease. Journal of the American Medical Association 277:715-721, 1997.
20 The GUSTO-III Investigators. An international, multicenter, randomized comparison of reteplase with
alteplase for acute myocardial infarction. New England Journal of Medicine 337:1118-23, 1997.
21. The BARI Investigators. The Bypass Angioplasty Revascularization Investigation (BARI): Influence of
diabetes on 5-year mortality and morbidity in a randomized trial comparing CABG and PTCA in patients
with multivessel disease. Circulation 96:1761-1769, 1997.
22. The PARAGON Investigators. An international, randomized, controlled trial of lamifiban, a platelet
glycoprotein IIb/IIIa inhibitor, heparin, or both in unstable angina. Circulation 97:2386-2395, 1998.
23. The PURSUIT (Platelet glycoprotein IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin
Therapy) Trial Investigators. Inhibition of the platelet glycoprotein IIb/IIIa with eptifibatide in patients with
acute coronary syndromes without persistent ST-segment elevation. New England Journal of Medicine
339:436-443, 1998.
24. EPISTENT Investigators. Randomized placebo-controlled and balloon-angioplasty-controlled trial to
assess safety of coronary stenting with use of platelet glycoprotein IIb/IIIa blockade. The Lancet 352:87-
92, 1998.
25. The PARADIGM Investigators. Combining thrombolysis with the platelet glycoprotein IIb/IIIa inhibitor
lamifiban: Results of the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion
Gain in Myocardial Infarction (PARADIGM) Trial. Journal of the American College of Cardiology 32:2003-
10, 1998.
26. BARI Investigators. Seven year outcome in the Bypass Angioplasty Revascularization Investigation
(BARI) by treatment and diabetic status. Journal of the American College of Cardiology 35:1122-29,
2000.
27. ASSENT-2 (Assessment of the Safety and Efficacy of a New Thrombolytic) Investigators. Single-bolus
tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 doubleblind
randomized trial. The Lancet 354:716-722, 1999.
28. The SYMPHONY Investigators. A randomized comparison of sibrafiban, an oral platelet glycoprotein
IIb/IIIa receptor antagonist, with aspirin for acute coronary syndromes. The Lancet 355:337-345, 2000.
29. The SPEED Group (Strategies for the Patency Enhancement in the Emergency Department).
Randomized trial of abciximab with and without low-dose reteplase for acute myocardial infarction.
Circulation 101:2788-2794, 2000.
30. The 2nd SYMPHONY Investigators. Aspirin, sibrafiban, or both to prevent ischemic events after acute
coronary syndromes: A randomized, double-blind, multicenter trial. Circulation 103:1727-1733, 2001.
31. The PARAGON-B Investigators. Randomized, placebo-controlled trial of titrated intravenous lamifiban for
acute coronary syndromes. Circulation 105:316-321, 2002.
32. The GUSTO IV-ACS Investigators. Glycoprotein IIb/IIIa receptor blocker abciximab does not improve
outcome in patients with acute coronary syndromes without early coronary revascularization. The Lancet
357: 1915-24, 2001.
33. The GUSTO V Investigators. Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy
or combination low dose fibrinolytic therapy and platelet glycoprotein IIb/IIIa inhibition: The GUSTO 5
Trial. The Lancet 357:1905-1914, 2001.
34. HERO-2 Trial Investigators. Thrombin-specific anticoagulation with bivalirudin versus heparin in patients
receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 Trial. The Lancet 358:1855-63,
2001.
35. The Direct Thrombin Inhibitor Trialists' Group. Direct thrombin inhibitors in acute coronary syndromes:
principal results of a meta-analysis based on individual patients' data. The Lancet 359:294-302, 2002.
36. PCAT Collaborators. Primary coronary angioplasty compared with intravenous thrombolytic therapy for
acute myocardial infarction: Six-month follow-up and analysis of individual patient data from randomized
Bibliography | Eric J. Topol, M.D. | June 2011
Page 72

trials. American Heart Journal 145:47-57, 2003.
37. Green RC, Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, Brown T, Eckert SL, Butson M,
Sadovnick AD, Quaid KA, Chen C, Cook-Deegan R, Farrer LA; REVEAL Study Group. Disclosure of
APOE genotype for risk of Alzheimer's disease. New England Journal of Medicine. 16;361(3):245-54,
2009. [PMID 19605829]
Books
1. Topol EJ ed., Acute Coronary Intervention, Alan R. Liss, Inc., New York, New York, 1988.
2. Topol EJ ed., Textbook of Interventional Cardiology, W.B. Saunders, Philadelphia, PA, 1990.
3. Topol EJ ed., Textbook of Interventional Cardiology, 2nd Edition, W.B. Saunders, Philadelphia, PA, 1994.
4. Topol EJ, Serruys PW eds., Current Review of Interventional Cardiology, Current Medicine, Philadelphia,
PA, 1994.
5. Fuster V, Ross R, Topol EJ eds., Atherosclerosis and Coronary Artery Disease, Lippincott-Raven Press,
Philadelphia, PA, 1996.
6. Popma JJ, Leon M, Topol EJ ed., Atlas of Interventional Cardiology, W.B. Saunders, Philadelphia, PA,
1994.
7. Khan MG, Bartlett JG, Chopra S, Topol EJ eds., Medical Diagnosis and Therapy, Lea & Febiger,
Malvern, PA, 1994.
8. Topol EJ, Serruys PW ed., Current Review of Interventional Cardiology, 2nd Edition, Current Medicine,
Philadelphia, PA, 1995.
9. Khan MG, Topol EJ, Saksena S, Goodwin JF eds. Heart Disease Diagnosis and Therapy, Williams &
Wilkins, Baltimore, MD, 1996.
10. LaFont A, Topol EJ eds. Arterial Remodeling: A Critical Factor in Restenosis, Kluwer, Norwell, MA, 1997.
11. Verstraete M, Fuster V, Topol EJ ed. Cardiovascular Thrombosis - Thrombocardiology, 2nd Edition,
Lippincott-Raven, Philadelphia, PA, 1998.
12. Topol EJ ed., Textbook of Cardiovascular Medicine, Lippincott-Raven, Philadelphia, PA, 1998.
13. Topol EJ ed., Acute Coronary Syndromes, Marcel Dekker, New York, NY, 1998.
14. Topol EJ ed., Comprehensive Cardiovascular Medicine, Lippincott-Raven, Philadelphia, PA, 1998.
15. Topol EJ ed., Textbook of Interventional Cardiology, 3rd Edition, W.B. Saunders, Philadelphia, PA, 1999.
16. Lincoff AM, Topol EJ eds., Platelet IIb/IIIa Inhibitors in Cardiology, Humana Press Inc., Totowa, NJ, 1999.
17. Marso SP, Griffin BP, Topol EJ. Manual of Cardiovascular Medicine, Lippincott Williams & Wilkins,
Philadelphia, PA, 2000.
18. Topol EJ ed., The Cleveland Clinic Heart Book, Hyperion, New York, NY, 2000.
19. Topol EJ ed., Acute Coronary Syndromes, 2nd Edition, Marcel Dekker, New York, NY, 2001.
20. Lanzer P, Topol EJ eds., PanVascular Medicine, Springer Verlag, Heidelberg, Germany, 2002.
21. Topol EJ ed., Textbook of Cardiovascular Medicine, 2nd Edition, Lippincott-Williams & Wilkins,
Philadelphia, PA, 2002.
22. Topol EJ ed., Textbook of Interventional Cardiology, 4th Edition, Harcourt/Elsevier, Philadelphia, PA,
2003.
23. Roffi M, Meier B, Topol EJ eds., The Essentials of Cardiology, Handheldmed (HHM), 2003.
24. Cho L, Griffin BP, Topol EJ. The Cardiology Intensive Board Review Question Book. Lippincott Williams
& Wilkins, Philadelphia, PA, 2003.
25. Topol EJ ed., Atlas of Atherothrombosis, Science Press Ltd, London, England, 2004.
26. Aviles RJ, Messerli AW, Askari A, Penn MS, Topol EJ eds., Introductory Guide to Cardiac
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Catheterization, Lippincott-Williams & Wilkins, Philadelphia, PA, 2004.
27. Griffin BP, Topol EJ, Hook M, McRae AT, III, Messerli A. Manual of Cardiovascular Medicine, 2nd Edition,
Lippincott Williams & Wilkins, Philadelphia, PA, 2004.
28. Fuster V, Nabel E, Topol EJ eds., Atherothrombosis and Coronary Artery Disease, 2nd Edition,
Lippincott-Williams & Wilkins, Philadelphia, PA, 2005.
29. Topol EJ ed., Acute Coronary Syndromes, 3rd Edition, Marcel Dekker, New York, NY, 2005.
30. Topol EJ ed., Textbook of Cardiovascular Medicine, 3rd Edition, Lippincott-Williams & Wilkins,
Philadelphia, PA, 2007.
31. Topol EJ ed., Textbook of Interventional Cardiology, 5th Edition, Harcourt/Elsevier, Philadelphia, PA,
2008.
32. Topol EJ, Teirstein PS eds., Textbook of Interventional Cardiology, 6th Edition, Harcourt/Elsevier,
Philadelphia, PA, 2010.
Book Chapters
1. Topol EJ, Fortuin NJ: Cardiac tumors and carcinoid heart disease. In: Fortuin NJ ed. Current Therapy in
Cardiovascular Disease, B.C. Decker, Inc., Toronto, 354-358, 1984.
2. Topol EJ, Califf RM: The role of tissue plasminogen activator in acute myocardial infarction. In: Califf RM,
Wagner GS eds. Acute Coronary Care 1987, Martinus Nijhoff Publishing, Hingham, MA, 73-87, 1986.
3. Topol EJ: Cardiac tumors and carcinoid heart disease. In: Fortuin NJ ed. Current Therapy in
Cardiovascular Disease - 2, B.C. Decker, Inc., Toronto, 311-314, 1986.
4. Topol EJ, O'Neill WW: Myocardial infarction: thrombolysis and angioplasty. In: Sobel B, Collen D,
Grossbard EB eds. Tissue Plasminogen Activators in Thrombolytic Therapy, Marcel Dekker, Inc., New
York, 87-114, 1987.
5. Pitt B, O'Neill WW, Topol EJ: Percutaneous transluminal coronary angioplasty after acute myocardial
infarction. In: Roberts R ed. Current Perspective in Coronary Care, Excerpta Medica, Princeton, NJ, 17-
20, 1987.
6. Collen D, Topol EJ: Tissue Plasminogen Activator. In: Topol EJ ed. Acute Coronary Intervention, Alan R.
Liss, Inc., New York, New York, 35-48, 1987.
7. Topol EJ: Thrombolysis and angioplasty in myocardial infarction (TAMI). In: Topol EJ ed. Acute
Coronary Intervention, Alan R. Liss, Inc., New York, New York, 153-174, 1987.
8. Topol EJ: Direct or sequential PTCA. In: Topol EJ ed. Acute Coronary Intervention, Alan R. Liss, Inc.,
New York, New York, 79-94, 1987.
9. Topol EJ: Lessons from the TAMI Study. In: Califf RM, Mark D, Wagner GS eds. Acute Coronary Care in
the Thrombolytic Era, Yearbook Publishers, New York, 316-330, 1988.
10. Topol EJ: Mechanical reperfusion in acute myocardial infarction. In: Gotsman MS ed. Reperfusion in
Acute Myocardial Infarction, 659-669, 1988.
11. Califf RM, Mark DM, Topol EJ: Current and future randomized trials of acute coronary intervention. In:
Califf RM, Mark D, Wagner GS eds. Acute Coronary Care in the Thrombolytic Era, Yearbook Publishers,
New York, 347-363, 1988.
12. Topol EJ: Mechanical interventions: acute coronary balloon angioplasty. 
In: Anderson J ed. Critical Care
Cardiology, Progress in Critical Care Medicine, Vol 3, Karger, Basel, Switzerland, 63-89, 1988.
13. Topol EJ: Early hospital discharge in the era of myocardial reperfusion. In: Califf RM, Mark D, Wagner
GS eds. Acute Coronary Care in the Thrombolytic Era, Yearbook Publishers, New York, 657-669, 1988.
14. Topol EJ: Thrombolytic intervention. In: Topol EJ ed. Textbook of Interventional Cardiology, W.B.
Saunders, Philadelphia, PA, 76-120, 1989.
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15. Meyer J, Erbel R, Pop T, Topol EJ: Angioplasty and surgical revascularization after thrombolysis. In:
Julian D, Kubler W, Norris RM, Swan HJC, Collen D, Verstraete M eds. Thrombolysis in Cardiovascular
Disease, Marcel Dekker, Inc., New York, New York, 179-201, 1989.
16. Topol EJ: Mechanical interventions for Acute Myocardial Infarction. In: Topol EJ ed. Textbook of
Interventional Cardiology, W.B. Saunders, Philadelphia, PA, 269-299, 1989.
17. Muller D, Topol EJ: Reperfusion in acute myocardial infarction. In: Parmley WW, Chatterjee K eds.
Cardiology, J.P. Lippincott, Philadelphia, PA, Chapter 11, 1-19, 1990.
18. Sutton J, Topol EJ: Thrombolysis and angioplasty for acute ischemic syndromes. In: Serruys PW ed.
Coronary Angioplasty: A Controlled Model for Ischemia, Martinus Nijhoff, Norwell, MA, 351-370, 1989.
19. Topol EJ: How Should Intravenous Thrombolytic Agents for Acute Myocardial Infarction Be Selected? In:
Cheitlin MD ed. Dilemmas in Clinical Cardiology, 
FA Davis, New York, 57-76, 1990.
20. Muller D, Topol EJ: Should thrombolytic therapy be used in suspected cases of myocardial infarction by
appropriately trained paramedics? In: Gitnick G ed. -Debates in Medicine, Yearbook Publishers, New
York, 56-77, 1990.
21. Topol EJ: Interventions in acute myocardial infarction. In: Meier B ed. Interventional Cardiology, Hans
Huber Publishers, Bern, Switzerland, 185-210, 1990.
22. Topol EJ: Selection of thrombolytic agents for clinical use. In: Haber E and Braunwald E eds.
Thrombolysis: Basic Contributions and Clinical Progress, C.V. Mosby Yearbook, St. Louis, Missouri, 301-
314, 1991.
23. Popma JJ, Topol EJ: The role of coronary angioplasty in acute myocardial infarction. In: Anderson JL ed.
Modern Management of Acute Myocardial Infarction in the Community Hospital, Marcel Dekker, Inc., New
York, New York, 303-330, 1991.
24. Popma JJ, Ellis SG, Topol EJ: Angiographic results following directional coronary atherectomy. In:
Holmes D ed. Atherectomy, Blackwell Scientific Publications, Cambridge, Massachusetts, 81-105, 1992.
25. Muller DWM, Topol EJ: Trial design in restenosis: problems and solutions. 
In: Schwartz RS ed.
Restenosis, Blackwell Scientific Publications, Cambridge, Massachusetts, 138-168, 1993.
26. Grines CL, O’Neill WW, Topol EJ: The emerging role of combination thrombolytic therapy in acute
myocardial infarction. In: Bates E ed. Adjunctive Therapy for Acute Myocardial Infarction, Marcel Dekker,
Inc., New York, New York,
271-282, 1992.
27. Topol EJ: Foreword. In: Serruys PW, Strauss B, King S eds. Restenosis in the Coronary Arteries
Following Intervention with New Mechanical Devices, Kluwer Academic Publishers, Norwell,
Massachusetts, 131:V-VII, 1992.
28. Bates ER, Topol EJ: Thrombolytic mortality trials. In Bates E ed. Adjunctive Therapy for Acute Myocardial
Infarction, Marcel Dekker, Inc., New York, New York, 63-89, 1992.
29. Muller DW, Topol EJ: Reperfusion in acute myocardial infarction. In: Chatterjee K, Cheitlin MD, Karliner
J, Parmley WW, Rapaport E, Scheinman M eds. Cardiology. An Illustrated Text/Reference. Lippincott,
Philadelphia, PA, 69(2):163-178, 1991.
30. Muller DW, Topol EJ: New Devices for Coronary Revascularization. In: Topol EJ ed. Textbook of
Interventional Cardiology – Update 1. W B Saunders, Philadelphia, PA, 1-14, 1991.
31. Muller DW, Topol EJ: Reperfusion therapy for acute myocardial infarction. 
In: Topol EJ ed. Textbook of
Interventional Cardiology – Update 4. W B Saunders, Philadelphia, 59-74, 1992.
32. Lincoff AM, Topol EJ: Abrupt Vessel Closure. In: Topol EJ ed. Textbook of -Interventional Cardiology –
Update 5. W B. Saunders, Philadelphia, PA, 75-92, 1992.
33. Sutton JM, Topol EJ: Coronary angioplasty strategies for the treatment of acute myocardial infarction. In:
Faxon D ed. Practical Angioplasty, Raven Press, New York, New York, 135-152, 1993.
34. Abdelmequid A, Topol EJ: Thrombolytic Therapy In Acute Myocardial Infarction. In: Agnelli G ed. Year
Book on Thrombolytic Therapy, Excerpta Medica, Amsterdam, The Netherlands, 57-99, 1993.
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35. Topol EJ, Califf RM, Sigmon KM, Lee KL: Thrombolytic Therapy for Women With Acute Myocardial
Infarction: Is There a Gender Gap? In: Wenger, Speroff & Packard ed. Cardiovascular Health and
Diseases in Women, LeJacq Communications Inc., Greenwich, Connecticut, 109-112, 1993.
36. Brown DL, Topol EJ: The Late Assessment of Thrombolytic Efficacy (LATE) Trial: Impact and
Implications. In: Becker RC ed. The Modern Era of Coronary Thrombolysis, Kluwer Academic Publishers,
Norwell, Massachusetts, 121-134, 1993.
37. Muller D, Topol EJ: Overview of Coronary Atherectomy. In: Topol EJ ed. Textbook of Interventional
Cardiology, 2nd Edition, W.B. Saunders, Philadelphia, PA, 678-684, 1994.
38. Topol EJ: Quality of Care in Interventional Cardiology. In: Topol EJ ed. Textbook of Interventional
Cardiology, 2nd Edition, W.B. Saunders, Philadelphia, PA, 1354-1366, 1994.
39. Topol EJ: Thrombolytic Intervention. In: Topol EJ ed. Textbook of Interventional Cardiology, 2nd Edition,
W.B. Saunders, Philadelphia, PA, 68-111, 1994.
40. Sutton JM, Topol EJ: Principles of Thrombolytic Therapy: Impact on Mortality and Left Ventricular
Function in Acute Myocardial Infarction. In: Woosley R ed. Cardiovascular Pharmacology and
Therapeutics, Churchill Livingstone, Inc., New York, New York, 481-498, 1994.
41. Stone G, Grines CL, Topol EJ: Percutaneous Transluminal Coronary Angioplasty. In: Topol EJ ed.
Current Review of Interventional Cardiology, W.B. Saunders Co., Philadelphia, Pennsylvania, 7.1-7.24,
1994.
42. Lincoff AM, Topol EJ: Abrupt Vessel Closure. In: Topol EJ ed. Textbook of Interventional Cardiology, 2nd
Edition, W.B. Saunders, Philadelphia, PA, 207-230, 1994.
43. Khan MG, Topol EJ: Acute Myocardial Infarction. In : Khan MG ed. Medical Diagnosis and Therapy, Lea
& Febiger, Malvern, Pennsylvania, 65-88, 1994.
44. Levy RJ, Golomb G, Trachy J, Labhasetwar V, Muller D, Topol EJ: Strategies for treating arterial
restenosis using polymeric controlled release implants. In: Gebelein CG ed. Biotechnology and Bioactive
Polymers, Lionfire, Inc., Edgewater, Florida, 259-268, 1994.
45. Topol EJ: Mechanical Interventions for Acute Myocardial Infarction. In: Topol EJ ed. Textbook of
Interventional Cardiology, 2nd Edition, W.B. Saunders, Philadelphia, PA, 292-317, 1994.
46. DeFranco A, Topol EJ: Angiography and Angioplasty. In: Julian D, Braunwald E eds. Management of
Acute Myocardial Infarction, W.B. Saunders, Philadelphia, PA, 107-146, 1994.
47. Topol EJ: Thrombolytic Therapy in Acute Myocardial Infarction. In: Agnelli G ed. Yearbook on
Thrombolytic Therapy, Excerpta Medica, Amsterdam, The Netherlands, 57-104, 1994.
48. Califf RM, Topol EJ: The paradigm of acute reperfusion and the GUSTO trial. In: Califf RM, Mark D,
Wagner GS eds. Acute Coronary Care in the Thrombolytic Era, Mosby-Year Book, Inc. St. Louis, MO, 69-
83, 1995.
49. DeFranco A, Sutton JM, Topol EJ: Role of Coronary Angiography after Acute Myocardial Infarction. In:
Califf, Mark D & Wagner GS ed. Acute Coronary Care in the Thrombolytic Era, 2nd Edition, Mosby-Year
Book, St. Louis, MO, 391-406, 1995.
50. Pietrolungo JF, Topol EJ: Thrombolytic Therapy in Acute Myocardial Infarction. In: Comerota AJ ed.
Thrombolytic Therapy, 2nd Edition, Lippincott-Raven, Philadelphia, PA, 349-398, 1995.
51. Topol EJ: Intravascular Ultrasound; Cost/Benefits in the Treatment with Percutaneous Transluminal
Coronary Angioplasty; Revascularization using New Devices; Clinical Aspects of Restenosis after
Coronary Angioplasty; Some Considerations regarding Thrombolytic Therapy; Invasive Approach for the
Treatment of Acute Myocardial Infarction. In: Pajaron A, Jose S, de Prada JA ed. Ischemic Heart Disease,
NCR, S.A., Barcelona, Spain 43-195, 1995.
52. Stone G, Grines CL, Topol EJ: Update on Percutaneous Transluminal Coronary Angioplasty. In: Topol
EJ, Serruys PW, eds. Current Review of Interventional Cardiology, 2nd Edition, Current Medicine,
Philadelphia, Pennsylvania, 1-57, 1995.
53. Lefkovits J, Topol EJ: Direct Thrombin Inhibitors in Acute Coronary Syndromes and Coronary
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Angioplasty. In: Topol EJ, Serruys PW, eds. Current Review of Interventional Cardiology, 2nd Edition,
Current Medicine, Philadelphia, Pennsylvania, 71-88, 1995.
54. Boehrer JD, Topol EJ: Platelet IIb/IIIa Blockade for Prevention of Abrupt Closure and Restenosis. In:
Topol EJ, Serruys PW, eds. Current Review of Interventional Cardiology, 2nd Edition, Current Medicine,
Philadelphia, Pennsylvania, 89-101, 1995.
55. Moliterno DJ, Topol EJ. Restenosis following coronary intervention. In: Topol EJ, ed. Textbook of
Interventional Cardiology -Update 17. W.B. Saunders, Philadelphia, Pennsylvania. 1995.
56. Lincoff AM, Topol EJ: Thrombolytic Therapy. In: Fuster V, Ross R, Topol EJ eds. Atherosclerosis and
Coronary Artery Disease, Lippincott-Raven Press, New York, New York, 955-977, 1996.
57. Topol EJ. Introduction: Atherectomy. In: Sigwart U, Bertrand M, Serruys PW, eds. Handbook of
Cardiovascular Interventions, Churchill Livingstone, New York, New York, 721-722, 1996.
58. Moliterno D, Topol EJ: Clinical Evaluation of Restenosis. In: Fuster V, Ross R, Topol EJ eds.
Atherosclerosis and Coronary Artery Disease, Lippincott-Raven Press, New York, New York, 1505-1526,
1996.
59. Elliott J, Topol EJ: Lessons from CAVEAT I and II Trials. In: Bertrand M, Serruys P, Sigwart U eds. The
Handbook of Cardiovascular Interventions, Churchill Livingstone, -London, England 729-738, 1996.
60. DeFranco A, Topol EJ: Elective Coronary Intervention. In: Bertrand M, Serruys P, Sigwart U eds. The
Handbook of Cardiovascular Interventions, Churchill Livingstone, London, England 413-430, 1996.
61. Moliterno D, Topol EJ: Thrombolytic Therapy in Acute Myocardial Infarction. In: Messerli FH ed.
Cardiovascular Drug Therapy, 2nd Edition. W.B. Saunders Co., Philadelphia, Pennsylvania, 1430-1442,
1996.
62. Horrigan M, Topol EJ: Angioplasty strategies in acute myocardial infarction. In: Smith TW ed.
Cardiovascular Therapeutics, W.B. Saunders, Philadelphia, PA, 600-620, 1996.
63. Pietrolungo J, Topol EJ: Thrombolytics and New Antiplatelet Agents. In: Ellis SG, Holmes DA eds.
Strategic Approaches in Coronary Intervention, Williams & Wilkins, Baltimore, Maryland, 668-697, 1996.
64. Horrigan M, Topol EJ: Coronary Stents: Definition of Unsatisfactory Results not Treated by Stenting. In:
Sigwart U ed. Endoluminal Stenting, W.B. Saunders Ltd., London, England, 252-262, 1996.
65. Boehrer J, Topol EJ: Aorto-ostial Stenosis. In: Ellis SG, Holmes DA eds. Strategic -Approaches in
Coronary Intervention, Williams & Wilkins, Baltimore, Maryland, 309-320, 1996.
66. Khan MG, Topol EJ: Acute Myocardial Infarction. In: Khan MG ed. Heart Disease Diagnosis and
Therapy, Williams and Wilkins, Baltimore, MD, 1-59, 1996.
67. Moliterno DJ, Topol EJ: Percutaneous versus surgical coronary revascularization: A summary of the
RITA, CABRI, GABI, EAST, and BARI Trials. In: Topol EJ ed. Textbook of Interventional Cardiology –
Update 23. W B Saunders, Philadelphia, PA. 335-344, 1996
68. Mak K-H, Topol EJ: Platelet glycoprotein IIb/IIIa inhibitors for acute coronary syndromes and
percutaneous coronary intervention. In: Topol EJ ed. Textbook of Interventional Cardiology – Update 24.
W B Saunders, Philadelphia, PA. 345-362, 1996
69. DeFranco A, Topol EJ: Functional Testing in Patients with Previous Coronary Interventions. In: Marwick
TH ed. Cardiac Stress Testing and Imaging, Churchill Livingston, New York, NY, 323-354, 1996.
69A. Erickson BR, Topol EJ. Local Drug Delivery for Prevention of Restenosis. In Verstraete M ed. Vessels,
Excerpta Medica, Amsterdam, the Netherlands, 2(2): 22-32, 1996.
70. Topol EJ: Foreword. In Marwick TH ed. Cardiac Stress Testing and Imaging, Churchill Livingston, New
York, NY, XI-XII, 1996.
71. Topol EJ: Discussions throughout. In: Safian RD and Freed M ed. Tough Calls in Interventional
Cardiology, Physician's Press, Birmingham, MI, 1996.
72. Rogers WJ, Topol EJ. The role of angiography. In: Fuster V, Ross R, Topol EJ, eds. Atherosclerosis and
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73. Mousa SA, Topol EJ: Recent Advances in the Development of Platelet GPIIb/IIIa Receptor Antagonists.
In Holmes D ed. Current Review of Interventional Cardiology, Current Medicine, Philadelphia, PA, 113-
130, 1997.
74. Erickson BR, Topol EJ: Direct Thrombin Inhibitors in Arterial Thrombosis. In Hirsh J. and Weitz J ed. New
Therapeutic Agents in Thrombosis and Thrombolysis, Marcel Dekker, New York, NY. 169-189, 1997.
75. Eccleston D, Topol EJ: Clinical Trials of Restenosis. In: Feuerstein, GZ, ed. Coronary Restenosis from
Genestics to Therapeutics, Marcel Dekker Publishers, Inc., New York, NY, 333-381, 1997.
76. Topol EJ, Mark D: Chronic Coronary Artery Disease. In: Talley JD, ed. Cost Effective Diagnosis and
Treatment of Coronary Artery Disease, Williams & Wilkins Medical Publishers, Inc., Baltimore, Maryland,
168-177, 1997.
77. Lincoff AM, Topol EJ: Interventional Catheterization Techniques (Balloon Angioplasty, Valvuloplasty, and
Related Procedures). In: Braunwald E ed. Heart Disease, 5th Edition, W.B. Saunders, Philadelphia, PA,
1366-1391, 1997.
78. Topol EJ: Foreword. In: Thompson P, ed. Coronary Care Manual, Churchill Livingston, London, England,
XII-XIV, 1997.
79. Topol EJ: Foreword. In Becker RC ed. Textbook of Coronary Thrombosis and Thrombolysis, Kluwer
Academic Publishers, Norwell, Massachusetts, XV, 1997.
80. Topol EJ: Clinical Cardiology: The History. In: Topol EJ, ed. Comprehensive Cardiovascular Medicine,
Lippincott-Raven, Philadelphia, PA, 315-321, 1998.
81. Brener S, Topol EJ: Thrombolysis for AMI: Third Generation (r-PA, n-PA, TNK, STAR, bat-PA). In Topol
EJ ed. Acute Coronary Syndromes, Marcel Dekker, New York, NY, 167-192, 1998.
82. Lefkovits J, Topol EJ: Advances in Anti-Platelet Therapy for Acute Cardiovascular Disease. In Topol EJ
ed. Acute Coronary Syndromes, Marcel Dekker, New York, NY, 327-360, 1998.
83. Migrino R, Topol EJ: Review of the GUSTO Trials (I, II and III). In Topol EJ ed. Acute Coronary
Syndromes, Marcel Dekker, New York, NY, 461-500, 1998.
84. Steinhhubl S, Topol EJ: Stenting for Acute Coronary Syndromes. In Topol EJ ed. Acute Coronary
Syndromes, Marcel Dekker, New York, NY, 529-554, 1998.
85. Kapadia SR, Topol EJ: Cardiac Trauma. In: Topol EJ ed. Comprehensive Cardiovascular Medicine,
Lippincott-Raven, Philadelphia, PA,1097-1110, 1998.
86. Topol EJ: Thrombolytic Therapy in Acute Myocardial Infarction. In: Agnelli G ed. Yearbook on
Thrombolytic Therapy, Excerpta Medica, Amsterdam, The Netherlands, 83-120, 1998.
87. Moliterno D, Topol EJ: Restenosis: Epidemiology and Treatment. In Topol EJ ed. Comprehensive
Cardiovascular Medicine, Lippincott-Raven, Philadelphia, PA, 2397-2432, 1998.
88. Topol EJ, Califf RM: Quality Assessment and Outcome-Effectiveness. In Topol EJ ed. Comprehensive
Cardiovascular Medicine, Lippincott-Raven, Philadelphia, PA, 1259-1274, 1998.
89. Topol EJ, Van de Werf F: Acute Myocardial Infarction: Early Management. In Topol EJ ed.
Comprehensive Cardiovascular Medicine, Lippincott-Raven, Philadelphia, PA, 425-466, 1998.
90. Moliterno D, Topol EJ: Restenosis: Epidemiology and Treatment. In Topol EJ ed. Textbook of
Cardiovascular Medicine, Lippincott-Raven, Philadelphia, PA, 2065-2100, 1998.
91. Topol EJ, Van de Werf F: Acute Myocardial Infarction: Early Management. In: Topol EJ, ed. Textbook of
Cardiovascular Medicine, Lippincott-Raven, Philadelphia, PA, 395-435, 1998.
92. Topol EJ, Califf RM: Quality of Care in Cardiovascular Medicine. In: Topol EJ, ed. Textbook of
Cardiovascular Medicine, Lippincott-Raven, Philadelphia, PA, 1119-1133, 1998.
93. Mayer E, Robinson K, Topol EJ. Homocysteine and Coronary Artery Disease. In: Freeman GL ed.
Developments in Cardiology, W.B. Saunders, Philadelphia, PA, 1998.
94. Topol EJ: Clinical Cardiology: The History. In: Topol EJ, ed. Textbook of Cardiovascular Medicine,
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95. Lefkovits J, Topol EJ. Platelet Glycoprotein IIb/IIIa. In: Topol EJ ed. Textbook of Cardiovascular Medicine
Update Series, Lippincott Williams & Wilkins, Philadelphia, PA, Volume 1, No. 6, 1998.
96. Van de Werf, F, Topol EJ. Acute phase treatment of myocardial infarction: selecting patients for
thrombolysis. In: Verstraete M, Fuster V, Topol EJ ed. Cardiovascular Thrombosis - Thrombocardiology,
2nd Edition, Lippincott-Raven, Philadelphia, PA, 471-484, 1998.
97. Narins CR, Topol EJ. Angiogenesis and transmyocardial revascularization. In: Topol EJ ed. Textbook of
Cardiovascular Medicine Update Series, Lippincott Williams & Wilkins, Philadelphia, PA, Volume 1, No. 3,
1998.
98. Lincoff AM, Topol EJ: Abrupt Vessel Closure. In: Topol EJ ed. Textbook of Interventional Cardiology, 3rd
Edition, W.B. Saunders, Philadelphia, PA, 163-187, 1999.
99. Topol EJ: Catheter-Based Reperfusion for Acute Myocardial Infarction. In: Topol EJ ed. Textbook of
Interventional Cardiology, 3rd Edition, W.B. Saunders, Philadelphia, PA, 265-279, 1999.
100. Narins CR, Topol EJ: Percutaneous Myocardial Revascularization and Angiogenesis. In: Topol EJ ed.
Textbook of Interventional Cardiology, 3rd Edition, W.B. Saunders, Philadelphia, PA, 664-683, 1999.
101. Topol EJ: Quality of Care in Interventional Cardiology. In: Topol EJ ed. Textbook of Interventional
Cardiology, 3rd Edition, W.B. Saunders, Philadelphia, PA, 910-920, 1999.
102. Thamilarasan M, Topol EJ. Thrombolysis: GUSTO-I. In: Nash IS and Fuster V ed. Efficacy of Myocardial
Infarction Therapy in 1998, Marcel Dekker, Inc., New York, NY. 31-52, 1999.
103. Brener S, Topol EJ. Primary Angioplasty. In: Cannon CP ed. The Management of Acute Coronary
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104. Lefkovits J, Topol EJ: Role of Platelet-Inhibitor Agents in Coronary Artery Disease. In: Topol EJ ed.
Textbook of Interventional Cardiology, 3rd Edition, W.B. Saunders, Philadelphia, PA, 3-24, 1999.
105. Narins CR, Topol EJ: Approach to Restenotic Lesions. In: Topol EJ ed. Textbook of Interventional
Cardiology, 3rd Edition, W.B. Saunders, Philadelphia, PA, 417-432, 1999.
106. Topol EJ: Thrombolytic Intervention. In: Topol EJ ed. Textbook of Interventional Cardiology, 3rd Edition,
W.B. Saunders, Philadelphia, PA, 78-109, 1999.
107. Topol EJ. Platelet glycoprotein IIb/IIIa inhibition in the management of acute coronary syndromes. In: E.
Braunwald ed. Harrison's Online Textbook, McGraw Hill, February 10, 1999.
108. Barsness GW, Ohman EM, Califf RM, Kereiakes DJ, George BS, Topol EJ.. The Thrombolysis and
Angioplasty in Myocardial Infarction (TAMI) trials: A decade of reperfusion strategies. In: Timmis GC, ed.
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109. Lincoff AM, Topol EJ. Overview of the glycoprotein IIb/IIIa inhibitor in interventional trials. In: Lincoff AM,
Topol EJ, eds. Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease. Totowa, NJ, Humana
Press, 169-197, 1999.
110. Roffi M, Topol EJ. Anticoagulant therapy in unstable angina In: Topol EJ ed. Textbook of Cardiovascular
Medicine Update Series, Lippincott Williams & Wilkins, Philadelphia, PA, Vol 3(2):1-11, 2000.
111. Steinhubl SR, Topol EJ. The role of oral platelet GP IIb/IIIa antagonists in the setting of percutaneous
coronary intervention. In: Ellis SG and Holmes D eds. Strategic Approaches in Coronary Intervention, 2nd
edition, Lippincott, Williams & Wilkins, Philadelphia, PA, 564-574, 2000.
112. Lewis D, Topol EJ, Wang Q.; Ischemic Heart Disease. Nature Encyclopedia of Life Sciences 10:508-515,
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114. Narins CR and Topol EJ. Angiographic versus clinical restenosis. In: Holmes DR and Serruys PW.
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116. Chiu AC, Topol EJ. Comparative evaluation of t-PA versus streptokinase: the GUSTO-I Trial. In:
Bachmann F ed. Fibrinolytics and Antifibrinolytics, Springer-Verlag, Heidelberg, Germany, 261-286, 2001.
117. L'Allier P, Topol EJ, Ellis SG. Catheter-based interventions for treatment of acute coronary syndromes.
In: DeBono D and Sobel B eds. Challenges in Acute Coronary Syndromes, Blackwell Science, Malden,
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118. Bhatt D, Topol EJ. Embolization in acute coronary syndromes. In: Topol EJ ed. Acute Coronary
Syndromes, 2nd edition, Marcel Dekker, New York, NY, 79-110, 2001.
119. Robbins M, Topol EJ. Inflammation as the principal pathway to acute coronary syndromes. In: Topol EJ
ed. Acute Coronary Syndromes, 2nd edition, Marcel Dekker, New York, NY, 1-31, 2001.
120. Brener S, Topol EJ. Third generation thrombolytic agents. In: Topol EJ ed. Acute Coronary Syndromes,
2nd edition, Marcel Dekker, New York, NY, 243-270, 2001.
121. Steinhubl S, Topol EJ. Primary angioplasty and stenting in acute MI. In: Topol EJ ed. Acute Coronary
Syndromes, 2nd edition, Marcel Dekker, New York, NY, 373-390, 2001.
122. Topol EJ: Thrombolytic Therapy in Acute Myocardial Infarction. In: Agnelli G ed. Yearbook 2000 on
Thrombolytic Therapy, Excerpta Medica, Amsterdam, The Netherlands, 2001.
123. Lefkovits J, Topol EJ. Intravenous antiplatelet therapy for acute coronary syndromes. In: Topol EJ ed.
Acute Coronary Syndromes, 2nd edition, Marcel Dekker, New York, NY, 419-452, 2001.
124. Patel V, Topol EJ. Lessons from the GUSTO 1-4 trials. In: Topol EJ ed. Acute Coronary Syndromes, 2nd
edition, Marcel Dekker, New York, NY, 725-764, 2001.
125. Topol EJ. Foreword. In: Thompson PD, ed. Exercise and Sports Cardiology, McGraw-Hill, Medical Pub.
Division, New York, NY, 2001.
126. Bhatt DL, Topol EJ. Acute coronary syndromes. In: Topol EJ ed. Textbook of Cardiovascular Medicine
Update Series, Lippincott Williams & Wilkins, Philadelphia, PA, Vol 4(2): 1-14, 2001.
127. Topol EJ. Foreword. In: Rimmerman CM, Jain AK eds. Interactive Electrocardiography, CD-ROM and
workbook, Lippincott Williams & Wilkins, Philadelphia, PA, 2001.
128. Topol EJ. Preface. In: Boland J and Muller D eds. Cardiology and Cardiac Catheterization: the essential
guide, Harwood Academic Publishers, Singapore, 2001.
129. Agah R, Plow E, Topol EJ. GPIIb/IIIa antagonists. In: Michelson A ed. Platelets, Academic Press, New
York, NY, 769-785, 2002.
130. Tolleson TR, Topol EJ, Harrington RA. Adjunctive therapies in percutaneous coronary interventions
(PCI). In: Serruys PW, Colombo A, Leon MB, Kutryk M eds. Coronary Lesions: A Pragmatic Approach,
Martin Dunitz, London, England, 291-318, 2002.
131. Aronow HD, Topol EJ. Antiplatelet therapy in cardiology. In: Gresele P, Page CP, Vermylen J, and Fuster
V eds. Platelets in Thrombotic and non-Thrombotic Disorders, Cambridge University Press, Cambridge,
UK, 2002.
132. Topol EJ. History of cardiovascular medicine. In: Topol EJ ed. Textbook of Cardiovascular Medicine, 2nd
edition, Lippincott Williams & Wilkins, Philadelphia, PA, 265-272, 2002.
133. Topol EJ, Van de Werf F. Acute myocardial infarction: Early diagnosis and management. In: Topol EJ ed.
Textbook of Cardiovascular Medicine, 2nd edition, Lippincott Williams & Wilkins, Philadelphia, PA, 385-
419, 2002.
134. Kapadia SR, Topol EJ. Cardiac trauma. In: Topol EJ ed. Textbook of Cardiovascular Medicine, 2nd
edition, Lippincott Williams & Wilkins, Philadelphia, PA, 901-915, 2002.
135. Topol EJ, Califf RM. Medical Errors and Quality of Care in Cardiovascular Medicine. In: Topol EJ, ed.
Textbook of Cardiovascular Medicine, 2nd edition, Lippincott Williams & Wilkins, Philadelphia, PA, 1005-
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136. Bhatt DL, Topol EJ. Post-myocardial Infarction Management. In: Topol EJ ed. Textbook of
Cardiovascular Medicine, 2nd edition, Lippincott Williams & Wilkins, Philadelphia, PA, 463-482, 2002.
137. Moliterno DJ, Topol EJ. Restenosis: epidemiology and treatment. In: Topol EJ ed. Textbook of
Cardiovascular Medicine, 2nd edition, Lippincott Williams & Wilkins, Philadelphia, PA, 1715-1750, 2002.
138. Califf RM, Topol EJ. Considerations in the design and conduct of clinical studies and the interpretation of
quantitative evidence. In: Topol EJ, ed. Textbook of Cardiovascular Medicine, 2nd edition, Lippincott
Williams & Wilkins, Philadelphia, PA, CD-ROM only, 2002.
139. Lincoff AM, Topol EJ. Overview of the glycoprotein IIb/IIIa interventional trials. In: Lincoff AM, ed. Platelet
glycoprotein IIb/IIIa inhibitors in cardiovascular disease. 2nd Edition, Humana Press, Totowa, NJ, 167-
199, 2003.
140. Chan AW, Topol EJ. Enhanced understanding of statins: Mechanisms and indications. In: Topol EJ ed.
Textbook of Cardiovascular Medicine Update Series, Lippincott Williams & Wilkins, Philadelphia, PA, Vol
5(5):1-16, 2002.
141. Lefkovits J, Topol EJ. Role of platelet-inhibitor agents in coronary artery disease. In: Topol EJ ed.
Textbook of Interventional Cardiology, 4th Edition, Harcourt/Elsevier, Philadelphia, PA, 3-32, 2003.
142. Topol EJ. Thrombolytic intervention. In: Topol EJ ed. Textbook of Interventional Cardiology, 4th Edition,
Harcourt/Elsevier, Philadelphia, PA, 91-118, 2003.
143. Bhatt DL, Topol EJ. Periprocedural myocardial infarction and emboli protection. In: Topol EJ ed.
Textbook of Interventional Cardiology, 4th Edition, Harcourt/Elsevier, Philadelphia, PA, 251-266, 2003.
144. Brener S, Topol EJ. Catheter-based reperfusion for acute myocardial infarction. In: Topol EJ ed.
Textbook of Interventional Cardiology, 4th Edition, Harcourt/Elsevier, Philadelphia, PA, 285-301, 2003.
145. Narins CR, Topol EJ. In-stent restenosis. In: Topol EJ ed. Textbook of Interventional Cardiology, 4th
Edition, Harcourt/Elsevier, Philadelphia, PA, 455-473, 2003.
146. Chew DP, Topol EJ. Stents: indications and limitations. In: Topol EJ ed. Textbook of Interventional
Cardiology, 4th Edition, Harcourt/Elsevier, Philadelphia, PA, 631-647, 2003.
147. Topol EJ. Quality of care in interventional cardiology. In: Topol EJ ed. Textbook of Interventional
Cardiology, 4th Edition, Harcourt/Elsevier, Philadelphia, PA, 1021-1031, 2003.
148. Aronow HD, Topol EJ. Detection of vulnerable plaque. In: Topol EJ ed. Textbook of Interventional
Cardiology, 4th Edition, Harcourt/Elsevier, Philadelphia, PA, 1063-1087, 2003.
149. Brener SJ and Topol EJ. Primary Angioplasty. In: Cannon C ed. Management of Coronary Syndromes,
2nd Edition, The Humana Press, Inc., Totowa, NJ, 281-313, 2003.
150. Aronow HD and Topol EJ. Identifying the vulnerable plaque and the vulnerable patient. In: Theroux P ed.
Acute Coronary Syndromes: A companion to Braunwald's Heart Disease. Harcourt Health Sciences, WB
Saunders, Philadelphia, PA, 661-676, 2003.
151. Sachar R, Topol EJ. Future perspectives in the management of ACS. In: Bhatt DL, Flather M, eds.
Handbook of Acute Coronary Syndromes, Remedica Publishing, London, UK, 275-302, 2004.
152. Topol EJ. Foreword. In: Savage RM and Aronson S eds. Comprehensive Textbook of Intraoperative
Transesophageal Echocardiography, Lippincott Williams & Wilkins, Philadelphia, PA, 2005.
153. Agah R, Topol EJ. Genetic basis of acute coronary syndromes. In: Topol EJ ed. Acute Coronary
Syndromes, 3rd Edition. Marcel Dekker, New York, NY, 33-57, 2005.
154. Bhatt D, Topol EJ. Embolization as a pathological mechanism. In: Topol EJ ed. Acute Coronary
Syndromes, 3rd Edition. Marcel Dekker, New York, NY, 77-101, 2005.
155. Gurm H, Topol EJ. Intravenous glycoprotein IIb/IIIa receptor inhibitor agents for acute coronary
syndromes. In: Topol EJ ed. Acute Coronary Syndromes, 3rd Edition. Marcel Dekker, New York, NY,
369-395, 2005.
156. Mak K-H, Topol EJ. Diabetes in ACS. In: Topol EJ ed. Acute Coronary Syndromes, 3rd Edition. Marcel
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157. Yen M, Topol EJ. The microcirculation in MI. In: Topol EJ ed. Acute Coronary Syndromes, 3rd Edition.
Marcel Dekker, New York, NY, 615-633, 2005.
158. McWilliams MJ, Topol EJ. Percutaneous coronary intervention in the elderly. In: Gerstenblith G ed.
Cardiovascular Disease in the Elderly. Humana Press, Totowa, NJ, 159-177, 2005.
159. Gurm H, Topol EJ. Definitions of acute coronary syndromes In: Fuster V, Nabel E, Topol EJ eds.
Atherothrombosis and Coronary Artery Disease, 2nd Edition, Lippincott-Williams & Wilkins, Philadelphia,
PA, 791-803, 2005.
160. Sachar R, Topol EJ. Local gene and cell delivery devices. In: Duckers E, Nabel E, Serruys P eds.
Essentials of Restenosis for the Interventional Cardiologist. Humana Press, Totowa, NJ, Chapter 27, 421-
444, 2007.
161. Saw J, Topol EJ. Antiplatelet therapy. In: Cho L, Schneck M eds. Cerebrovascular Disease - A Cardiac
Perspective, Blackwell/Futura, Blackwood, NJ, in press, 2006.
162. Vivekananthan DP, Bhatt D, Topol EJ. Glycoprotein IIb/IIIa in percutaneous coronary intervention. In:
Ellis S ed. Strategic Approaches in Coronary Intervention, 3rd edition, Lippincott-Williams & Wilkins,
Philadelphia, PA, in press, 2006.
163. Fathi RB, Bhatt D, Topol EJ. Clopidogrel and other platelet ADP inhibitors. In: Kristensen SD, DeCaterina
R, Moliterno DJ eds. Therapeutic Strategies in Thrombosis, Clinical Publishing Co., Oxford, England, in
press, 2006.
164. Jefferson BK, Topol EJ. Genetics in cardiovascular medicine. In: Griffin B, Rimmerman C, Topol EJ eds.
Cleveland Clinic Board Review, Lippincott, Williams & Wilkins, Philadelphia, PA, in press, 2006.
165. Topol EJ. Foreword. In: Schoenhagen P. ed. Atlas and Manual of Cardiovascular Multidetector
Computed Tomography. Taylor & Francis, New York, in press, 2006.
166. Agah R, Plow E, Topol EJ. GPIIb/IIIa antagonists. In: Michelson A ed. Platelets, 2nd Edition, Academic
Press, Burlington, MA, 1145-1163, 2007.
167. Topol EJ. History of cardiovascular medicine. In: Topol EJ ed. Textbook of Cardiovascular Medicine, 3rd
edition, Lippincott Williams & Wilkins, Philadelphia, PA, 186-192, 2007.
168. Topol EJ, Van de Werf F. Acute myocardial infarction: Early diagnosis and management. In: Topol EJ ed.
Textbook of Cardiovascular Medicine, 3rd edition, Lippincott Williams & Wilkins, Philadelphia, PA, 280-
302, 2007.
169. Kapadia SR, Topol EJ. Cardiac trauma. In: Topol EJ ed. Textbook of Cardiovascular Medicine, 3rd
edition, Lippincott Williams & Wilkins, Philadelphia, PA, 698-709, 2007.
170. Califf RM, Topol EJ. Considerations in the design, conduct, and interpretation of quantitative clinical
evidence. In: Topol EJ ed. Textbook of Cardiovascular Medicine, 3rd edition, Lippincott Williams &
Wilkins, Philadelphia, PA, DVD chapter, 2007.
171. Jefferson B, Kotte-Marchant K, Topol EJ. Platelet genomics. In: Bhatt D ed. Platelets in Cardiovascular
Disease, Imperial College Press, London, UK, in press, 2007.
172. Hubbard CA, Topol EJ. Genomics of myocardial infarction. In: Willard HF and Ginsburg GS eds.
Handbook of Genomic Medicine, Elsevier, New York, NY, in press, 2007.
173. Anwaruddin S, Topol EJ. Inflammation status. In. Topol EJ ed. Textbook of Interventional Cardiology, 5th
edition, Harcourt/Elsevier, Philadelphia, PA, in press, 2007.
174. Chacko M, Topol EJ. Thrombolytic intervention. In. Topol EJ ed. Textbook of Interventional Cardiology,
5th edition, Harcourt/Elsevier, Philadelphia, PA, in press, 2007.
175. Schork NJ, Malo N. Topol EJ Study Design and Statistical Methods in Pharmacogenomics Research:
From Candidate Genes to Genome Wide Screens. Pharmacogenetics and Personalized Medicine, in
press 2007.
176. Damani SB, Topol EJ. The Genomics of Cardiovascular Disease. Genomic and Personalized Medicine,
2nd ed, Chapter 50, Academic Press Elsevier Inc, Philadelphia, PA, in press, 2011.
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Letters to the Editor
1. Traill TA, Topol EJ, Fortin NJ: Hypertensive hypertrophic cardiomyopathy. New England Journal of
Medicine 312:1456, 1985.
2. Topol EJ, Califf RM, George BS, Kereiakes DJ, Candela RJ, Abbottsmith CW, Pitt B, Stack RS:
Thrombolysis and angioplasty in acute myocardial infarction. New England Journal of Medicine 318:578,
1988.
3. Topol EJ: Shortening the hospital stay for myocardial infarction. New England Journal of Medicine
319:1021, 1988.
4. Topol EJ, Gacioch GM: Discordance in results of right coronary intervention. Circulation, 84:955, 1991.
5. Califf RM, Woodlief, LH, Topol EJ: Point of view: Use of left ventricular function as prognostic factor.
Circulation, 83:1452-1453, 1991.
6. Ohman EM, Stack RS, Topol EJ, Califf RM: Consequences of reocclusion after successful reperfusion
therapy in acute myocardial infarction. Circulation, 83:1454, 1991.
7. Sane DC, Stump DC, Topol EJ, Sigmon KN, Clair WK, Kereiakes DJ, George BS, Stoddard MF, Bates
ER, Stack RS, Califf RM: Profile of racial differences in thrombolytic effects of streptokinase. Circulation
84:2206, 1991.
8. Topol EJ: Thrombolytic therapy in acute MI: Safe during menses? Journal of Critical Illness 7:14, 1992
9. Califf RM, Popma J, Topol EJ: Small trials and new therapies. Circulation 85:1636-1637, 1992.
10. Topol EJ, Califf RM: Thrombolytic therapy for elderly patients. New England Journal of Medicine 327:45-
47, 1992.
11. Topol EJ, Ellis SG: Coronary angioplasty practice in the United States. Circulation 89:508, 1994.
12. Topol EJ, Ellis SG, Califf RM. Coronary atherectomy versus angioplasty. New England Journal of
Medicine 329:1892,1993.
13. Topol EJ, Califf RM, Van de Werf F. Thrombolytic therapy for acute myocardial infarction: GUSTO
criticized. New England Journal of Medicine 330:505-506, 1994.
14. Omoigui N, Topol EJ. On-site facilities and utilization of coronary angiography after myocardial infarction.
New England Journal of Medicine 330:289, 1994.
15. Lee KL, Califf RM, Topol EJ. The last word on GUSTO, for now. Annals of Internal Medicine 120:970,
1994.
16. Topol EJ, Califf RM, Lee KL. Update on GUSTO data. New England Journal of Medicine 331:277-278,
1994.
17. Lee KL, Topol EJ, Califf RM. More on the GUSTO trial. Annals of Internal Medicine 121:819-820, 1994.
18. Topol EJ. Coronary-stent placement compared with balloon angioplasty. New England Journal of
Medicine 332:538, 1995.
19. Abdelmeguid A., Topol EJ. Creatine kinase elevation with percutaneous coronary revascularization.
Circulation, 93:397-398, 1996.
20. Pilote L, Topol EJ. Regional variation across the United States for the management of acute myocardial
infarction. The New England Journal of Medicine 334(3):194-195, 1996.
21. Topol EJ, Nissen S. Our preoccupation with coronary luminology: the dissociation between clinical and
angiographic findings in ischemic heart disease. Circulation 94:1142, 1996.
22. Silver MJ, Topol EJ, Young JB. Amiodarone in congestive heart failure. The New England Journal of
Medicine, 333:1639-41, 1995.
23. Migrino RQ, Moliterno DJ, Topol EJ. Preinfarction angina. The New England Journal of Medicine 335:59-
61, 1996.
Bibliography | Eric J. Topol, M.D. | June 2011
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24. Mak K-H, Topol EJ. Cost efficacy modeling of catheter reuse. Journal of the American College of
Cardiology, 28:1640-1641, 1996.
25. Langer A, Topol EJ, Wilcox RG, Armstrong PW. Non-Q wave infarction after thrombolytic therapy.
Journal of the American College of Cardiology, 28:1638-1639, 1996.
26. Abdelmeguid A, Topol EJ. Creatine kinase elevation with percutaneous coronary revascularization.
Circulation 95:1665-66, 1997.
27. van der Giessen WJ, van Beusekom HMM, Serruys PW, Lincoff AM, Ellis SG, Topol EJ, Schwartz RS,
Holmes DR. Inflammatory response to coronary artery stenting. Circulation 96:2091-2093, 1997.
28. Pilote L, Califf RM, Topol EJ. Use of coronary angiography and revascularization after acute MI. New
England Journal of Medicine 336:1024-1025, 1997.
29. Ohman EM, Califf, RM, Topol EJ. Cardiac troponins in acute coronary syndromes. New England Journal
of Medicine 336:1257-1259, 1997.
30. Topol EJ, Califf RM, Van de Werf F. Heparin versus hirudin for acute coronary syndromes. New England
Journal of Medicine 336:730-731, 1997.
31. Gent M. for the CAPRIE Steering Committee. A randomized, blinded, trial of clopidogrel versus aspirin in
patients at risk of ischemic events (CAPRIE), Lancet 349:806, 1997.
32. Ohman, EM, Califf, RM, Topol EJ. Trials in myocardial infarction. (IMPACT-AMI) Circulation 96:3814-
3815, 1997.
33. Simes RJ, Kleiman NS, Califf RM, Topol EJ. Early mortality differences in GUSTO I: no evidence against
the early hazard phenomenon. Circulation 96:3780-3781, 1997.
34. Ellis SG, Topol EJ, Betriu A, Califf RM. GUSTO IIb: Direct PTCA response. New England Journal of
Medicine 337:1168-1170, 1997.
35. Lincoff AM, Topol EJ, Califf RM. Platelet glycoprotein IIb/IIIa receptor blockade after coronary
angioplasty. New England Journal of Medicine 337:1243-1245, 1997.
36. Topol EJ, Califf RM, Wilcox R. Thrombolytic therapy for myocardial infarction. New England Journal of
Medicine 338:545-547, 1998.
37. Narins CR, Topol EJ, Holmes Jr., DR. A call for provisional stenting. Circulation 98:2645, 1998.
38. Roe MT, Bowen TE, Topol EJ. Management of non-Q-wave myocardial infarction. New England Journal
of Medicine 339(19):1396-1397, 1998.
39. Topol EJ, Lincoff AM, Sapp S. Coronary stenting and use of abciximab. The Lancet 352:1311-1312,
1998.
40. Harrington RA, Simoons ML, Topol EJ. Eptifibatide in acute coronary syndromes. New England Journal
of Medicine 340:60-61, 1999.
41. Topol EJ. Coronary artery stenting. New England Journal of Medicine 340:1367-68, 1999.
42. Steinhubl SR, Tan WA, Foody JM, Topol EJ. Incidence of TTP in stented patients treated with ticlopidine.
Journal of the American Medical Association 282:1718-1719, 1999.
43. Brener SB, Topol EJ, Jones AA, Cohn ED, Gainey PC, White HJ, Effron MB, Barr LA, Burchenal JEB,
Katz S, George BS, Cheek HB, Moses JW, Moliterno DJ. RAPPORT Trial. Circulation 99(25):3323-24,
1999.
44. Berger PB, Ellis SG, Holmes Jr. DR, Granger CB, Criger DA, Betriu A,
Topol EJ, Califf RM. Relationship
between delay in performing direct coronary angioplasty and early clinical outcome in patients with acute
myocardial infarction. Circulation Website Vol. 102:e29-e30, 2000.
45. Newby KH, Thompson T, Stebbins A, Califf RM, Topol EJ, Natale A. Sustained ventricular arrhythmias in
patients receiving thrombolytic therapy. Circulation WebSite Vol. 101:e237-e238, 2000.
46. Bhatt DL, Topol EJ. GP IIb/IIIa inhibitors and fibrinolysis in myocardial infarction. Journal of the American
Medical Association 284:3124-25, 2000.
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47. Newby LK. Bhapkar MV, Lee KL, Califf RM, Topol EJ on behalf of the SYMPHONY Investigators.
Randomization in the SYMPHONY trial. The Lancet, 356:1521-22, 2000.
48. Topol EJ. Conflict of Interest. The New England Journal of Medicine 344:1017, 2001.
49. Steinhubl SR, Kottke-Marchant K, Moliterno DJ, Rosenthal M, Topol EJ, Lincoff AM, Coller BS.
Attainment and maintenance of platelet inhibition through standard dosing of abciximab in patients
undergoing percutaneous coronary intervention--Response. Circulation 102:e186, 2000.
50. Chew DP, Bhatt DL, Lincoff AM, Moliterno DJ, Brener SJ, Wolski KE, Topol EJ. Optimal activated clotting
time during percutaneous coronary intervention. Circulation 104:e83-e84, 2001.
51. Bhatt DL, Chew DP, Topol EJ, Hirsch AT, Ringleb PA, Hacke W. Superiority of clopidogrel vs aspirin in
patients with prior cardiac surgery. Circulation 104:e76, 2001.
52. Chew DP, Bhatt DL, Sapp S., Topol EJ. Increased mortality with long-term platelet glycoprotein IIb/IIIa
antagonists. Circulation 104:109e, 2001.
53. Topol EJ. Comments on GUSTO V. The Lancet 358:1462, 2001.
54. Mukherjee D, Nissen S, Topol EJ. Counterpoint on COX-2 inhibitor article. We defend our data and
suggest caution. Cleveland Clinic Journal of Medicine 68:963-964, 2001.
55. Mukherjee D, Nissen S, Topol EJ. Cardiovascular events and COX-2 inhibitors. Journal of the American
Medical Association 286:2811-2812, 2001.
56. Chew DP, Bhatt DL, Lincoff AM, Moliterno DJ, Brener SJ, Wolski KE and Topol EJ. Defining the Optimal
Activated Clotting Times During Percutaneous Coronary Intervention: Aggregate Results From Six
Randomized Controlled Trials. Circulation 104:124e., 2001.
57. Jeremias A, Casserly I, Estess M, Smedira N, Topol EJ. Acute myocardial infarction due to coronary
artery compression by an aortic root pseudoaneurysm after aortic valve replacement. American Journal
of Medicine 110:417-418, 2001. [PMID 11294182]
58. Lincoff AM, Topol EJ, Kereiakes DJ, Mascelli MA, Deckelbaum LI, Barnathan ES, Patel KK, Frederick B,
Nakada MT. Abciximab suppresses the rise in levels of circulating inflammatory markers after
percutaneous coronary revascularization. Circulation 105:E74, 2002.
59. Mukherjee D, Nissen SE, Topol EJ. Lack of cardioprotective effect of naproxen. Archives of Internal
Medicine 162:2637, 2002. [PMID 12456255]
60. Bhatt DL, Topol EJ. The arterial inflammation hypothesis. Archives of Internal Medicine 162:2249-51,
2002. [PMID 12390076]
61. Aviles RJ, Topol EJ, Lauer MS. Troponin T levels in patients with ACS, with and without renal dysfunction.
New England Journal of Medicine 347:1723, 2002.
62. Moliterno DJ, Bertrand M, Neuman F-J, Topol EJ. TARGET 6 month follow-up. The Lancet 360:2086,
2002. [PMID 12504452]
63. Gibler WB, Armstrong PW, Holroyd B, Topol EJ. Response to articles 114 and 142. Annals of Emergency
Medicine 40:659-660, 2003.
64. Steinhubl SR, Berger PB, Mann JT, Fry ETA, DeLago A, Wilmer C, Topol EJ, for the CREDO
Investigators. Clopidogrel pretreatment in the CREDO trial. Journal of the American Medical Association
289:1926-27, 2003.
65. Topol EJ, Kottke-Marchant K, Gum P. Aspirin resistance and its clinical relevance. Journal of the
American College of Cardiology 42:1336-37, 2003. [PMID 14522509]
66. Lincoff AM, Topol EJ, for the REPLACE-2 Investigators. Glycoprotein IIb/IIIa inhibition in percutaneous
coronary interventions. Journal of the American Medical Association 290:1451, 2003.
67. Topol EJ. Anticoagulation in pregnant patients with heart valves. Summary of the APPCR
(Anticoagulation in Prosthetic Valves and Pregnancy Consensus Report) Panel. Archives of Internal
Medicine 163:2251-52, 2003. [PMID 14557227]
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68. Saw J, Topol EJ. Lack of adverse clopidogrel-atorvastatin clinical interaction. American Journal of
Cardiology 93:669-70, 2004. [PMID 14996608]
69. Vivekananthan D, Penn MS, Topol EJ. Antioxidant vitamins for prevention of cardiovascular disease. The
Lancet 362:920-21, 2003.
70. James SJ, Lindahl B, Siegbahn A, Stridsberg M, Venge P, Armstrong P, Barnathan ES, Califf RM, Topol
EJ, Simoons ML, Wallentin L. Heart-kidney interactions in ischemic syndromes. Circulation 109(5): e31-
32, 2004.
71. Khot UN, Khot MB, Topol EJ. Conventional risk factors in patients with CHD. Journal of the American
Medical Association 291:300-301, 2004.
72. Topol EJ. Natural history of aspirin resistance. Journal of the American College of Cardiology Vol
43(7):1332-33, 2004.
73. Wang Q, Rao S, Topol EJ. Genomewide linkage analysis. American Journal of Human Genetics 75:152-
4, 2004.
74. Casserly I, Topol EJ. Atherosclerosis and Alzheimer's disease. The Lancet 363:2091-92, 2004.
75. Steinhubl SR, Topol EJ. Risk reduction with long-term clopidogrel following percutaneous coronary
intervention. European Heart Journal 25:2169-70, 2004. [PMID 15571836]
76. Topol EJ. Rofecoxib, Merck, and the FDA. New England Journal of Medicine 351:2877-78, 2004.
77. Topol EJ. Arthritis medications and cardiovascular events. Journal of the American Medical Association
293:1976-77, 2005.
78. Wang Q, Rao S, Topol EJ. Miscues on the "lack of MEF2A mutations" in coronary artery disease.
Journal of Clinical Investigation 115:1399-1401, 2005. [PMID 15931371]
79. Topol EJ. Eric Topol responds. Fortune December 27, page 24, 2004.
80. Saw J, Brennan D, Topol EJ, Steinhubl SR, berger PB, Kerieakes DJ, Serebruany VL. CREDO trial.
Circulation 109:e230, 2004.
81. Topol EJ, Blumenthal D. Physicians and investments. Journal of the American Medical Association
294:1897-98, 2005.
82. Topol EJ. Nesiritide--not verified. New England Journal of Medicine 353:1525-27, 2005.
83. Sinnaeve PR, Simes J, Yusuf S, Garg J, Mehta S, Eikelboom J, Bittl JA, Serruys P, Topol EJ, Granger
CB. Direct thrombin inhibitors in acute coronary syndromes. European Heart Journal 22:2354-55, 2005.
84. Mukherjee D, Topol EJ, Moliterno DJ. Are tirofiban and abciximab identical in efficacy? European Heart
Journal 27:120, 2006. [PMID 16107485]
85. De Luca G, Suryapranata H, Stone GW, Antoniucci D, Tcheng JE, Neumann F-J, Bonizzoni E, Topol EJ,
Chiariello M. Relationship between patient's risl profile and benefits in mortality from adjunctive abciximab
to mechanical revascularization for ST-segment elevation myocardial infarction: A meta-regression
analysis of randomized trials. Journal of the American College of Cardiology Vol 47(3):685-86, 2006.
86. Topol EJ for the CHARISMA Investigators. Clopidogrel for the Prevention of Atherothrombotic Events.
New England Journal of Medicine 355:420-21, 2006.
87. Patay BA, Topol EJ. Is there a genetic basis for acute coronary syndrome? Nature Clinical Practice
Cardiovascular Medicine Epub Sept 18 2007 [PMID 17876345]
88. McCarthy JJ, Topol EJ, Validity of reported genetic risk factoirs for acute coronary syndrome. J American
Medical Association 298(15):1758, 2007 [PMID 17940228]
89. Suhar CJ, Hitchcock TM, Russo RJ, Topol EJ. Is computed tomographic angiography prognostic in
patients with cardiac systems? Journal of the American College Cardiology 51:1510, 2008. [PMID:
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Book Reviews
1. Topol EJ. Acute Myocardial Infarction. Gersh B, Rahimtoola S eds. Elsevier, New York, Mayo Clinic
Proceedings, 66:764, 1991.
2. Topol EJ. The Spirit of Enquiry. Glaser Sholem ed., Alan Sutton Publishing Limited, UK, The Lancet
347:381, 1996.
3. Topol EJ. Medical Blunders. Youngson R and Schott I eds., Robinson Publishers, London, England, The
Lancet 349:1403, 1997.
4. Topol EJ. The dawn of risk factors. A Change of Heart: How the People of Framingham Massachusetts,
Helped Unravel the Mysteries of Cardiovascular Disease. Levy D, Brink S eds. Knopf Publishers, USA,
Nature Medicine 11:1043, 2005.
Bibliography | Eric J. Topol, M.D. | June 2011
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