Supplement bij veertiende jaargang, april 2006 - NVMM

from clinical sources. A total of 83 patients (72 with
AIDS and 11 HIV negative) were studied with mycological
evidence of cryptococcosis (1997 through 2002). In both
groups, the frequency of clinical signs and symptoms were
similar except for neurological signs, which prevailed in
AIDS patients. Curiously, the HIV- negative patients did
not had an obvious predisposing illness and they had a
normal CD4/CD8 ratio. Cryptococcus neoformans infection
was found to be the initial AIDS - defining illness in
45.8% of the AIDS patients. Thirty three percent (7 of 21)
of the HIV + infected patients died in the first 2 weeks of
diagnosis. A fatal outcome, related to treatment failure
was associated (p