Flukazole C plus Selenium brochure - Virbac Animal Health Australia

War on fluke.
Ambush fluke before it attacks.
®
The only proven killer of 2 week old
early immature fluke in cattle.

Unmatched 1 potency against early immature fluke
combined with broad-spectrum parasite control.
Flukazole C plus Selenium is the only 2 product proven
by research to effectively control 2-week old fluke.
Trials 2 demonstrate no other product provides the
high level of control against early immature fluke.
Only Flukazole C plus Selenium carries an APVMA label
claim specifically for the control of 2-week old fluke 1 .

Superior Fluke Control.
Studies 2 have proven that Flukazole C plus Selenium stands alone
as the only product that can effectively control the damaging
2-week old early immature fluke.
The dual actives, oxfendazole and triclabendazole in Flukazole C
plus Selenium, work together to create a synergy that delivers
more potent killing of early immature fluke, especially the 2-week
old fluke.
What is synergy?
Synergy is where 1+1>2
That is, the sum of the parts combined is greater than the
individual components.
Oxfendazole = 0% efficacy against 2-week old immature fluke
Triclabendazole =

Flukazole C plus Selenium has proven efficacy over
pour-on fluke (triclabendazole + abamectin) drenches.
Two separate and independently run comparative
efficacy trials 2 have been recently undertaken.
In both studies Flukazole C plus Selenium
achieved ≥99% efficacy against 2 and 4 week
old stages of fluke.
The pour-on showed less than 8% efficacy on
2-week old stages in one study.
The pour-on group failed to demonstrate
effective control at 4 weeks in both studies.
Significant numbers of liver fluke survived
the pour-on treatment in both studies.
% Reduction in total fluke count 2 weeks
100
80
60
40
20
0
FLUKAZOLE C
plus Selenium
DPI Study Efficacy on 2-week old stages
NSW DPI study 2006
POUR-ON
triclabendazole + abamectin
% Reduction in total fluke count 4 weeks
100
80
60
40
20
0
FLUKAZOLE C
plus Selenium
VHR Study Efficacy on 4- week old stages
VHR study 2004
POUR-ON
triclabendazole + abamectin

Flukazole C plus Selenium has proven 2 efficacy over
other oral drenches.
Multiple comparative efficacy studies 2 have been
undertaken trialing Flukazole C plus Selenium
against reference oral fluke products.
Flukazole C plus Selenium has always
demonstrated efficacy of 99% or greater against
all stages of fluke.
Only Flukazole C plus Selenium offers
synergistic dual active control of liver fluke
resulting in significantly better control of
the early immature stages of liver fluke.
Competitor oral drenches do not achieve
the same level of control of the early immature
stages of liver fluke.
Comparative efficacy on 2 week old stages
% REDUCTION
100
90
80
70
60
50
40
30
FLUKAZOLE C
plus Selenium
NSW DPI trial 2006
FASIMEC® C
Comparative efficacy on 4 week old stages
% REDUCTION
100
90
80
70
60
50
40
30
FLUKAZOLE C
plus Selenium
FASIMEC® C

Why is it important to control immature fluke as early
as 2 weeks?
Early immature fluke burrow through the gut and are chemically attracted
to the liver. They penetrate the liver capsule and migrate through the liver.
These migrating fluke cause:
Haemorrhage and blood loss Liver scarring
Protein loss Anaemia
Reduced appetite Loss of liver function
Loss of productivity Possible death
Abattoir surveys on cattle sourced from irrigation areas have shown
liver condemnation rates of 80% 4 .
Condemned livers attract penalties and are a
substantial cost to producers and processors.
Healthy / normal liver
Using Flukazole C plus Selenium will minimise liver scarring caused by early immature flukes 2 .
The scarring from immature fluke
is evident on this liver.

Treating for 1 & 2 week old liver
fluke pays.
This weight gain study 6 by independant parasitologist Dr Joe Boray shows the advantage in
removing early immature fluke. The group that had early immature fluke removed with a
treatment at 1-2 weeks after infection had the greatest weight gain.
The average body weight of this group was 13kg heavier than the group that only had mature
fluke removed.
13Kg = an additional $26 in liveweight value
A 200 kg calf can be treated for approximately $2.60 5 . If the calf then gains an additional
13kg liveweight as a result of the effective treatment, the farmer will receive an extra
$26 in liveweight value @ $2/kg.
AGE OF LIVER FLUKE AT TIME OF TREATMENT
Weight gain in calves
following flukicide treatment against
various ages of fluke 6
1-2 WEEK STAGES
4-6 WEEK STAGES
8-12 WEEK STAGES
WEIGHT GAIN (KGS) OVER 20 WEEKS

Potent round worm control.
Flukazole C plus Selenium contains oxfendazole.
Oxfendazole is the newest and most potent active
in the benzimidazole group (BZ).
The BZ group of drenches are highly effective in
cattle. Unlike sheep, where there is a high level of
resistance to BZ’s, this is not the case with cattle.
Oxfendazole remains a safe and highly effective
drench active ingredient for cattle.
Flukazole C plus Selenium will control all
susceptible major gastro-intestinal mature
and immature round worm parasites in cattle.
Ostertagia (including inhibited stages)
Ostertagia ostertagi
Cooperia spp.
Haemonchus placei
Trichostrongylus axei
Trichostrongylus spp.
Oesophagostomum radiatum
Nematodirus spp.
Flukazole C plus Selenium also controls
lungworm and tapeworm.
Dictyocaulus viviparus
Moniezia spp.

Easy application.
Flukazole C plus Selenium offers a ready to use
product for both worms and fluke. There is no need
for mixing and no requirement to buy separate
fluke and worm drenches. Flukazole C plus
Selenium has been tested 2 for drenchability at an
independent mechanics laboratory.
Flukazole C plus Selenium was easier to deliver
than two oral competitor products.
The same NJ Phillips drenching equipment was
used on all tests.
Data shown is at room temperature.
Virbac recommend the use of the NJ Phillips 65mL
drencher with Hi-Flow floating hook - available in
the Flukazole C plus Selenium 15 litre gun pack.
kg FORCE
Maximum Force required to expel drench through equipment
25
20
15
10
FLUKAZOLE C
plus Selenium
FASIMEC C
FASINEX® 240 WATER

Lower meat withholdings and ESI than pour-on
triclabendazole products.
Pour-on triclabendazole based products can have very long export
slaughter intervals (ESI). The risk with using a product with a long withhold
is that the convenience of being able to sell cattle to export markets at
short notice is removed. Long meat withholdings can prevent farmers from
off-loading surplus stock in times of drought.
WHP 3 ESI 3
Flukazole C plus Selenium 21 56
Coopers Sovereign® 28 70
Genesis® Ultra Pour-on 49 140
Fasimec® Pour-on 49 140
No fluke product that is effective against all immature stages of fluke has a
shorter ESI than Flukazole C plus Selenium.

Flukazole C plus Selenium can be used in dairy cows
Shortest pre-calving usage interval of any triclabendazole based
fluke and worm control combination product on the market 7 .
Can be used up to 21 days prior to calving. Safe to use at dry off to
ensure no milk residues on re-entry to the lactating herd.
(At least 25% shorter pre-calving usage interval than other
combination products. 7 )
Flukazole C plus Selenium gives you an
extra 7 days grace for the cow to come back
into the milking herd.

With added selenium
Most of the high rainfall productive areas of Australia are selenium deficient.
In the higher rainfall areas where liver fluke are
present, nearly all areas are selenium deficient.
Flukazole C now contains selenium.
Selenium is a vital trace element, and plays an important
role in reproduction and the immune system.
Selenium supplementation has been linked to reduction
of mastitis. 8
Selenium deficient areas
Fluke areas

Flukazole C plus Selenium does not have activity against external
parasites such as lice. Whilst other oral products may claim the
control of sucking lice, they do not control biting lice.
In order to effectively control all important species of lice in
cattle, Virbac recommends using STAMPEDE® Pour-On for Cattle
and Sheep. Stampede has a unique mode of action. It is an insect
growth regulator (IGR) that acts on the immature stages of the
lice, preventing their development.
Stampede is an easy to apply pour-on treatment and is safe to
use in conjunction with Flukazole C plus Selenium.
Lice control in your cattle when using
Flukazole C plus Selenium
Stampede 9
Nil Milk withhold
10 day meat WHP
10 day ESI

Product information
Active constituents
120 g/L Triclabendazole
45.3 g/L Oxfendazole
1 g/L Selenium (As Sodium Selenate)
Cattle dose rate
1 mL per 10 kg bodyweight orally. The
dose of 1mL /10kg delivers 12 mg/kg of
triclabendazole, 4.5 mg/kg of oxfendazole
and 0.1 mg/kg selenium.
Withhold period
Meat 21 days
ESI 56 days
Milk Not less than 21 days before
calving, where cows are milked
for human consumption.
Parasites controlled
Liver Fluke (Fasciola hepatica)
Early immature, immature & mature
Roundworms
Lungworm
Tapeworm
Safety
Flukazole C plus Selenium is safe to
use in all classes of animals.
Flukazole C plus Selenium
Available in 15 litre, 15 litre gun pack,
5 litre and 1 litre pack sizes. Also
available in the FLUKEKILL pack with
15 litres of Flukazole C plus Selenium +
3 litres Virbamec Plus and a NJ Phillips
Powermaster, gas operated drencher.
Bodyweight Dose No. treated
kg 1L 5L 15L
Up to 100 10 mL 100 500 1500
101 – 150 15 mL 66 333 1000
151 – 200 20 mL 50 250 750
201 – 250 25 mL 40 200 600
251 – 300 30 mL 33 166 500
301 – 400 40 mL 25 125 375
401 – 500 50 mL 20 100 300
501 – 600 60 mL 17 83 250
601 – 650 65 mL 15 76 230
Over 650 kg 5mL/ 50kg bodyweight

For more information on liver fluke control
The FlukeKill TM program is a parasite control
program developed with the assistance
of Dr Joe Boray, parasitologist and world
authority on liver fluke.
Please send me a copy of the FlukeKill program
Name
Address
Post Code State
Phone
No. head of cattle
I would like to receive further information on:
Other fluke control products from Virbac.
Flukazole C plus Selenium trial results.
I am interested in having my cattle blood or milk tested for liver fluke*. Please contact me.
I am also interested in:
Further information on STAMPEDE Pour-On for lice.
Trace mineral supplementation in cattle.
Implant growth promotants (IGP) in cattle.
* Conditions apply

Delivery Address:
Locked Bag 1000
PEAKHURST DC NSW 2210
Virbac (Australia) Pty Ltd
Reply Paid 66605
PEAKHURST DC NSW 2210
No stamp required
if posted in Australia

References
1 Based on literature review and label claims of APVMA registered products as at November 2006.
2 Data on file.
3 WHP & ESI data taken from APVMA website and was correct at November 2006.
4 GL Watt. (1977) An abattoir survey of the prevalence of F. hepatica affected livers in cattle in
Victoria. M.Sc. Thesis. University of Melbourne.
5 Based on the approximate retail cost of Flukazole C plus Selenium Nov 2006.
6 JC Boray. (1982) Chemotherapy of fasciolosis. New South Wales Veterinary Proceedings 18:42-4.
7 APVMA registered products, Nov 2006.
8 Wichtel, JJ. A review of selenium deficiency in grazing ruminants. Part 1: New roles for selenium in
ruminant metabolism. New Zealand Veterinary Journal. 46,47-52.(1988).
9 Stampede Pour-On for Cattle and Sheep, Meat WHP Cattle = 10 days, Meat WHP Sheep = 7 days
ESI Cattle = 10 days, ESI Sheep = 7 days. Do not use on Dairy sheep.
® Flukazole C plus Selenium is a registered trademark of Virbac Australia Pty Ltd.
® Stampede is a registered trademark of Intervet.
® Genesis, Fasimec, Fasinex and Sovereign are all trademarks of their respective companies.

Virbac area managers
Name Area Mobile Email
Ben Fletcher Albany 0427877966 ben_fletcher@virbac.com.au
Craig Young Coonabarabran 0427988011 craig_young@virbac.com.au
Geoff Chambers Toowoomba 0428983718 geoff_chambers@virbac.com.au
Graham Morris Perth 0428460755 graham_morris@virbac.com.au
Joe Bown Southern Regional Manager 0427877212 joe_bown@virbac.com.au
John Patterson Armidale 0417202832 john_patterson@virbac.com.au
Mark Diprose Hamilton 0428544010 mark_diprose@virbac.com.au
Robert Fulford Launceston 0408131223 robert_fulford@virbac.com.au
Steve Heffernan Central Queensland 0427220740 steve_heffernan@virbac.com.au
Tom Thurley Bendigo 0407413152 tom_thurley@virbac.com.au
Ross Paton South Australia 0408824414 ross_paton@virbac.com.au
Peter Branson Crookwell 0409815416 peter_branson@virbac.com.au
Catriona MacCallum Dubbo 0429460798 catriona_maccullum@virbac.com.au
Roger Robilliard Yarrawonga 0428691158 roger_robilliard@virbac.com.au
Rohan Beale Gippsland 0409772163 rohan_beale@virbac.com.au
Available from
Customer support line 1800 009 847
Virbac (Australia) Pty Limited
15 Pritchard Place
Peakhurst • NSW • 2210
www.virbac.com.au