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P 02<br />

Economic evaluation of decreasing persistant hypertension with renal<br />

denervation device cutting costs of hypertension commorbidities in<br />

upcoming Croatian practice<br />

Vanesa Benković 1 , Ranko Stevanović 1 , Ana Ivičević 1 , Marko Matulović 2 ,<br />

Bojan Jelaković 3<br />

1 Croatian Society for Pharmacoeconomics and<br />

Health Economics Zagreb, Croatia<br />

2 Medtronic Zagreb, Croatia<br />

3 Department for nephrology and arterial<br />

hypertension, Clinical Hospital Centre Zagreb,<br />

Croatia<br />

Goal: to assess cost saving of decrease in persistant<br />

hypertension using renal denervation, a<br />

novel a catheter-based procedure<br />

Materials and Methods: using RCT data on decreasing<br />

commorbidities of hypertension and<br />

Framingham risk score a model is set to establish<br />

and structure cost in cardiovascular, cerebrovascular<br />

and renal commorbidities. Cost savings in<br />

commorbidities is assessed in Croatian setting<br />

using current prices and DRG tariffs. Epideimology<br />

data is taken from existing research such as<br />

registries and Croatian Health Survey.<br />

Results and Conclusion: Hypertension is a<br />

major risk factor for stroke, ischemic heart disease,<br />

heart failure, end stage renal disease and<br />

peripheral arterial disease. Renal denervation<br />

with the Symplicity Catheter System is a new<br />

catheter-based procedure for treatment-resistant<br />

48 Proofreading and translations are in the explicit responsibility of the authors.<br />

hypertension. Treatment-resistant hypertensive<br />

patients currently have no additional treatment<br />

options; they represent a significant unmet clinical<br />

need. Using one time renal denervation may<br />

significantly decrease systolic blood presure<br />

(SBP) - up to 32 mmHG SBP in six months, with<br />

sustainable effect. Decreasing the SBP is associated<br />

with decrease in incidence of ischaemic<br />

heart disease, renal failure, cerebrovascular insult<br />

and correlated mortality. As they all negatively<br />

impact quality of life they also increase the<br />

economic burden of the disease. The novel renal<br />

denervation procedure brings excellent options<br />

for unmet need in persistant hypertension and<br />

decreases cost in hospitalizations, drugs and rehabilitation<br />

from the budget holder and the hospital<br />

perspective.

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