Alexander Loewer - CV - MDC

Research
May 2011 – present
Curriculum vitae
Alexander Loewer
Berlin Institute of Medical Systems Biology
Max-­‐Delbrueck-­‐Center
Robert-­‐Roessle-­‐Strasse 10
13092 Berlin
e-­‐mail: alexander.loewer@mdc-­‐berlin.de
Group Leader, Berlin Institute of Systems Biology, Max-­‐Delbrueck-­‐Center, Berlin, Germany
“Signaling dynamics in single cells”
October 2005 – April 2011
Research Fellow, Department of Systems Biology, Harvard Medical School, Boston MA, USA
“p53 dynamics and the control of cell fate”
June 2001 – August 2005
Doctoral thesis in the group of Prof. Dr. Renato Paro at the Center for Molecular Biology
(ZMBH), University of Heidelberg, Germany
“Regulated intramembrane proteolysis of the Amyloid Precursor Protein (APP) family in
Drosophila melanogaster”
September 2000 – May 2001
Diploma thesis in the group of Prof. Dr. Renato Paro at the ZMBH, University of Heidelberg,
Germany
“Establishment of an in-vivo reporter system to study the processing of APP and Notch”
Education
June 2001 – August 2005
Dissertation in Molecular Cell Biology at the ZMBH, University of Heidelberg, Germany
October 1996 – May 2001
Undergraduate studies in Biology (Molecular Biology, Cell Biology, Biochemistry) at the
University of Heidelberg, Germany; Grade: 1.0
February 1986 – June 1995
Abitur (university entrance qualification) at the Lessing-­‐Gymnasium, Frankfurt, Germany;
Grade: 1.1
Honors
2005
2001
Doctor rer. nat. “Summa cum laude”, University of Heidelberg
Diploma “with distinction”, University of Heidelberg

Fellowships
October 2009 – April 2011
Charles A. King Trust Postdoctoral Research Fellowship
April 2009 – October 2009
Research Fellowship by the “Deutsche Forschungsgemeinschaft”
2002-2004
Travel fellowships by the GlaxoSmithKline Foundation, the Alzheimer Foundation and the
“Gesellschaft zur Förderung der Molekularbiologie”
June 1999 – May 2001
Fellowship by the “Studienstiftung des Deutschen Volkes”
Presentations
German Symposium on Systems Biology, Heidelberg, May 2009, “Basal p53 dynamics in
individual cells” (selected presentation)
q-­‐bio conference on cellular information processing, Santa Fee, August 2008 “p53 dynamics in
non-­‐stressed conditions” (spotlight presentation)
Invited Presentations
Systems Biology of Human Disease Conference, Boston, June 2010
Boston Area Systems and Synthetic Biology Meeting, Boston, January 2010
Current Topics in Systems Biology Series, D-­‐BSSE, ETH Zurich, Basel, April 2009
CSHL Meeting on Computational Cell Biology, Cold Spring Harbor, March 2009
New England Society of Microscopy, Gordon College, Wenham, December 2007
Teaching and other experience
2005-2010
Supervised Harvard Medical School Graduate students
2007-2009
Supervised Research Assistants to perform computer-­‐aided image analysis
2001-2005
Assistant teaching in the annual lab course „Molecular methods in developmental genetics“ at
the ZMBH, University of Heidelberg, Germany
2002-2004
Instructed and co-­‐supervised a technician, supervised three undergraduate students
1999
Assistant teaching in the lab course „Introduction to Molecular Biology“(3 weeks) at the ZMBH,
University of Heidelberg, Germany
Alexander Loewer CV 2

Research Article:
Publications
Toettcher, JE., Mock, C., Batchelor, E., Loewer, A., Lahav, G., (2010), “A synthetic-­‐natural hybrid
oscillator in human cells”, PNAS 107(39): 17047-­‐52
Loewer, A., Batchelor, E., Gaglia, G., Lahav, G. (2010) “Basal dynamics of p53 reveals
transcriptionally attenuated pulses in cycling cells”, Cell 142(1): 89-­‐100
Stempfle, D.*, Kanwar, R.*, Loewer, A.*, Fortini, M.E., Merdes, G., (2010), “In vivo Reconstitution of γ-­‐
Secretase in Drosophila Results in Substrate Specificity”, MCB 30(13): 3165-­‐75
Peshkin, L., Goni, J., Loewer, A., Kolluri, RS., Lahav, G., Wall, D. (2009) “Morphology from Texture in
Cytometry”, IJTS 16 (S10): 41-­‐55
Toettcher, JE.*, Loewer, A.*, Ostheimer, GJ., Yaffe, MB., Tidor, B., Lahav, G. (2009) „Distinct
mechanisms act in concert to mediate cell cycle arrest” PNAS 106(3): 788-­‐90
Batchelor, E., Mock, C., Bahn, I., Loewer, A. and Lahav, G. (2008) “Recurrent Initiation: A Mechanism
for Triggering p53 Pulses in Response to DNA Damage” Mol. Cell 30(3): 277-­‐89
Rusu P, Jansen A, Soba P, Kirsch J, Loewer A., Merdes G, Kuan YH, Jung A, Beyreuther K, Kjaerulff O,
Kins S. (2007) “Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on
the NPTY motif and is paralleled by defects in synaptic plasticity.” Eur J Neurosci. 25(4):1079-­‐86.
Soba, P., Eggert, S., Zentgraf, H., Kreger, S., Loewer, A., Merdes, G., Paro, R., Masters, C.L., Müller, U.,
Kins, S., and Beyreuther, K. (2006) “Cell interactions are promoted by trans-­‐dimerization of APP
family members, arranged as homo-­‐ or heterocomplexes in synaptic membranes.” EMBO J. 25(3):
653
Merdes, G., Soba, P., Loewer, A., Bilic, M. V., Beyreuther, K., and Paro, R. (2004) “Interference of
human and Drosophila APP and APP-­‐like proteins with PNS development in Drosophila.” EMBO J.
23(20): 4082-­‐95
Loewer, A., Soba, P., Beyreuther, K., Paro, R., and Merdes, G. (2004) “Cell-­‐type-­‐specific processing of
the amyloid precursor protein by Presenilin during Drosophila development” EMBO Rep. 5(4): 405-­‐
411.
* equal contribution
Review Article:
Batchelor, E., Loewer, A., Lahav, G. (2009) “The ups and downs of p53: Understanding protein
dynamics in single cells”, Nat Rev Cancer 9: 371-­‐377
Loewer, A., and Lahav, G. (2006) “Cellular conference call: external feedback affects cell-­‐fate
decisions.” Cell 124(6): 1128-­‐1130
Alexander Loewer CV 3