Pheochromocytoma - University of Colorado Denver

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Which Test? • Institutional bias • Catecholamines can be metabolized within chromaffin cells and released as metanephrines (or normetanephrines) independently <strong>of</strong> catecholamines which can occur at low rates
• Fractionated metanephrines – Urine (conjugated) – or plasma (free) – or both (lab expertise) – No consensus Which Test? • Not rely on binary testing – Continuous result – Trade <strong>of</strong>f sensitivity and specificity Pacak et al Nat Clin Pract Endocrinol Metab 2007
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Chris Raeburn Proteomic Hypothesis:
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Pheochromocytoma - University of Colorado Denver

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