Inside this issue: Through the Looking Glass - University of Michigan ...

Through the Looking Glass 

In 2006, the CDB department moved into its new home 

in the Biomedical Science Research Building (BSRB). 

Nestled in the block bounded by Huron Street, Zina 

Pitcher Place, Ann Street and Glen Avenue, the curvy 

glass building serves as the University of Michigan Medical 

School’s new front door. The BSRB is also known 

around campus as the building with the “Pringle” - 

named for the potato chip-shaped auditorium located in 

front of the building. 

Around 1,000 people work in the six story, 435,000square-foot 

building’s laboratories and offices. The facility 

provides cutting edge tools for researchers in cellular 

and molecular biology, neuroscience, immunology, and 

other areas. To encourage collaboration, space is organized along 

research areas rather than by academic departments. 

The building was recently awarded the prestigious 2007 Institute 

Honor Award For Architecture by the American Institute of Architects. 

A member of the jury called the building “a flagship for the 

campus.” 

We are thrilled to be working in such a wonderful building, and 

welcome you to stop by and visit us in our new home. 

In the meantime, enjoy the photos! 

Inside this issue: 

Through the Looking Glass ...........1 

Message from the Chair .................2 

Seminar Schedule ..........................2 

Profile: Billy Tsai ............................3 

Profile: Diane Fingar ..................4 

Profile: Sue O’Shea ......................5,6 

Faculty Awards ..............................7 

CDB Photo Gallery ........................7 

CDB Faculty ................................8,9 

Student News ...............................10 

Mailing Card ................................11

2 

As you can see by the pictures 

on the cover, we have moved 

and now live in a beautiful, lightfilled, 

open facility. The BSRB 

was designed to foster collaborative 

interactions, and the building 

design has more than fulfilled 

that purpose. We collaborate 

with other investigators located 

nearby and share equipment, facilities 

and (most importantly) 

ideas throughout the building: 

we feel fortunate to have been 

chosen to be among the first BSRB 

tenants. The entire Department has now moved, including 

the Center for Organogenesis, the Human Embryonic Stem 

Cell Core Laboratory, and the Microscopy and Image Analysis 

Laboratory. 

We have recruited ten extremely talented new faculty to the 

Department over the past four years, and are currently in the 

process of recruiting new senior faculty. Our graduate student 

program has increased proportionally during this time, 

and we are very proud of the accomplishments of our faculty 

(new and not so new), postdocs and students, some of which 

are highlighted in this newsletter. In addition to new personnel, 

we have expanded programs and services throughout 

the Department. 

The Center for Organogenesis continues to provide an intellectual 

focal point within the Department, and recently 

established a Bio-Artography program which generates interesting 

scientific images in a printed and framed art format. 

The proceeds from bioartography are used entirely for support 

of our graduate programs. This CFO program began 

with a booth at the Ann Arbor Art Fair and has grown to include 

a website http://bioartography.com/ so that interested 

people can view and purchase the art. We will feature more 

Organogenesis progress and vision in future newsletters. 

The Microscopy and Image Analysis Laboratory (MIAL) is a 

state-of-the-art centralized facility housing microscopes and 

other equipment that is used on a shared basis by investigators 

throughout the University. It is a fee-for-service-based 

facility open to all researchers (approximately 325 investigators 

are included among the MIAL’s 1,000 users). This facility 

offers help and instruction in the use of three confocal 

microscopes, three wide field fluorescent microscopes, TEM 

and SEM as well as a host of image analysis software. The 

MIAL recently purchased a Deltavision RT Image Restoration 

System for live cell imaging, keeping this core facility at 

the technological cutting edge. We will feature more of the 

MIAL’s services and equipment in future newsletters. 

Message from the Chair 

Cell & Developmental Biology • Spring 2007 

The Department has set aggressive and yet hopefully realistic 

goals for expansion of our base of academic excellence: 

we continue to seek additional funding for expansion of the 

Human Embryonic Stem Cell Core facilities as well as to establish 

the Center for Organogenesis as the first of its kind 

NIH-funded Center. Efforts will also continue to add cutting 

edge microscopy tools to the MIAL, and expand virtual microscopy 

teaching techniques for Medical Histology. 

I hope you enjoy this newsletter – the first of many to come. 

We look forward to hearing from you and want to know 

about your current position and achievements. And please, 

do feel free to come and visit us in our new home! 

James Douglas Engel, Ph.D. 

Chair 

Cell and Developmental Biology 

G. Carl Huber Professor of Developmental Biology 

CDB Seminars: 

5/16/07 Bob Lamb 

Professor, Northwestern University 

Co-host with Microbiology 

12pm-1pm, Seminar A,B & C BSRB 

9/12/07 John F. Fallon 

Professor, University of Wisconsin-Madison 

12pm-1pm, Seminar A,B & C BSRB 

10/10/07 Ken Zaret 

Professor - Fox Chase Cancer Center 

11/14/07 David Russell 

Professor, UT Southwestern 

12/12/07 Cliff Tabin 

Professor, Harvard Medical School


Billy was named a University of Michigan Biological Sciences 

Scholar and joined the CDB faculty as an Assistant Professor 

in September 2003. Since then he has become a Burroughs 

Wellcome Fund Fellow and received funding for his research 

program from NIH. 

Education: 

B.S., UCLA, 1989-1993 

(magna cum laude and Phi Beta Kappa) 

M.S., UCLA, 1993-1994 

Ph.D., Harvard University, 1994-1999 

Post-doctoral Training, Harvard Medical School, 1999-2003 

(Damon Runyon Fellow) 

Research focus: 

Molecular mechanism of membrane penetration by toxins 

and viruses 

To cause disease, bacterial toxins and viruses must transport 

across the complex membranous systems of the host 

cell. How the toxins and viruses penetrate the cellular membranes 

is poorly understood. The focus of my laboratory is to 

investigate the molecular mechanism by which the cholera 

toxin (CT) and the murine polyomavirus (Py) are transported 

across the endoplasmic reticulum (ER) membrane to reach 

the cytosol (see figure on right), a critical step in their infection 

pathway. 

Interactions between pathogens and their respective host 

cells expound on basic cellular events. Thus, CT and Py’s engagement 

of cellular machineries to cross the ER membrane 

will elucidate fundamental membrane transport processes. 

Moreover, identifying the cellular targets co-opted by these 

pathogens during infection may lead to the development of 

drugs that allow selective interference. The long term objective 

of my laboratory is to utilize the lessons gleaned from the 

cellular entry mechanism of these pathogens and apply them 

to a broader spectrum of human diseases. 

Profile: Billy Tsai, Assistant Professor 

Graduate Students: 

• Michele Forster studies the role of ER and cytosolic factors 

that facilitate retro-translocation of cholera toxin. 

• Emily Rainey studies the role of ERp29 on the penetration 

of polyomavirus across the ER membrane. 

• Kaleena Bernardi studies the role of the ER membrane 

protein Derlins on the retro-translocation of cholera toxin. 

• Mengding Qian studies the pathway used by polyomavirus 

to traffic from the plasma membrane to the ER. 

Undergraduate Student: 

• Jimmy Mahn studies the role of transmembrane PDI-like 

proteins in retro-translocation. 

3

4 

Diane joined the CDB faculty as an Assistant Professor in 

September 2004. Since then she has been awarded research 

grants from both the American Diabetes Association and the 

American Cancer Society for her work on a cellular signaling 

pathway that contributes to diabetes and cancer when 

disregulated, and her work has recently been funded by the 

NIH. 

Education: 

A.B., Princeton University, 1989 

Ph.D., Harvard Medical School, 1995 

Post-Doctoral Training, Massachusetts General Hospital 

(1995-1998) and Harvard Medical School (1998-2004) 


Regulation and function of signal transduction by mTOR 

mTOR, the mammalian target of rapamycin, is an evolutionarily 

conserved serine/threonine protein kinase that regulates 

fundamental cellular functions including cell growth/size and 

cell proliferation. mTOR associates with partner proteins to 

form different signaling complexes with distinct cellular functions 

(i.e. mTOR complex 1 = mTOR/raptor/mLST8). While 

mTOR signaling is tightly regulated by cellular signals, the 

molecular mechanisms by which these signals directly control 

mTOR signaling are poorly understood. The focus of the 

Fingar Lab is to understand the molecular mechanisms by 

which mTOR complexes are regulated by diverse physiological 

stimuli. As many proteins in mTOR signaling pathways 

are controlled by phosphorylation, we hypothesized that 

phosphorylation of mTOR itself and/or interacting partners 

regulate mTOR signaling and biological function. Indeed, 

we have identified several novel sites of cellular phosphorylation 

on mTOR and its interacting partners by tandem mass 

spectrometry. We are currently studying the regulation and 

function of these phosphorylation sites using both cell biological 

and biochemical approaches in order to decipher the 

molecular mechanisms of mTOR regulation. 


Profile: Diane Fingar, Assistant Professor 

We are also working toward developing a mouse model in 

which mTOR can be conditionally inactivated in a tissue-specific 

manner in order to elucidate the physiological function 

of mTOR signaling in vivo. As disregulated mTOR signaling 

has been implicated in diverse human diseases, the overall 

goal of this work is to better understand how disregulated 

signaling by mTOR complexes contributes to diabetes, cancer, 

heart disease, and obesity. Ultimately, this research may 

allow for the development of novel anti-disease therapeutics. 

Research Assistant Professor: 

• Ghada Soliman studies the role of mTOR in hyperlipidemia 

and thus cardiovascular disease; she is also working 

toward the generation of a mouse model for the study of 

mTOR function in vivo. 


• Katie Williams studies the regulation and function of a 

cluster of phosphorylation sites on raptor, an mTOR interacting 

partner. 

• Jenny Keller studies the regulation and function of a novel 

phosphorylation site on mTOR. 

• Bilgen Ekim and Brian Magnuson are 1 st year PIBS students 

who are fulfilling their IBS laboratory rotations. 

Research Technician 

• Hugo Acosta-Jaquez focuses on the regulation of phosphorylation 

of mTOR and its interacting partners.

Cell & Developmental Biology • Spring 2007 5 

Education: 

B.S., University of Nebraska, 1976 

Ph.D., Cambridge University, U.K., 1980 


Earliest events involved in the formation of the nervous system 

E6.5 embryo exposed to shRNA 

targeting noggin, chordin 

and follistatin. 

Research in our lab focuses on 

the earliest events involved in 

the formation of the nervous 

system. Because ES cells are 

a powerful model system 

to tease out the successive 

waves of gene expression and 

inhibition that shape the early 

embryo, we use embryonic 

stem cells (ESC) both mouse 

and human, and mouse embryos 

as model systems to 

investigate this early phase 

of development. Much of this 

work involves targeted misexpression 

of these molecules 

using transgenesis and RNAi 

on whole embryos. We are particularly interested the intermediates 

between induction of neural ectoderm from epiblast 

and neural differentiation. Lisa DeBoer is examining the role 

of BMP4 and the geminin gene in post-implantation development 

using shRNA and traditional transgenic approaches, 

and we have also used shRNA to knock-down multiple genes, 

including noggin chordin and follistatin. 

Using ESC we are examining the roles of noggin (Theresa 

Gratsch, Maria Morell), Wnt (Nicky Slawney) and FGF signaling 

(Maria Morell and Matt Velkey), the role of the bHLH 

neural determination genes, neurogenins (Matt Velkey) and 

geminin (Yao-Chang Tsan, Nicky Slawny) in neuronal differentiation. 

These studies have immediate relevance for understanding 

birth defects, lineage segregation in development 

and also provide a source of cells for transplantation and tissue 

engineering. 

Profile: K. Sue O’Shea, Professor 

We are collaborating with Phil Andrews, Gil Omenn and Anastasia 

Yocum to carry out proteomic screening of the noggin 

induced hESC neuronal cells, and have identified a number 

of novel targets. 

Another research project involves 

the molecular dissection 

of the neural stem cell 

niche. Dr. Maria Morell has 

developed a transgenic mouse 

that inducibly expresses noggin 

protein in neural stem 

cells. Induction of this transgene 

induces widespread 

neuronal differentiation of 

NSC. The long term goal of 

this work is to determine the role of noggin in the development 

and response of the nervous system to injury. 


• Nicky Slawny, Lisa DeBoer-Emmett, Yao-chang Tsan 

Undergraduate Students: 

• Eric Kilijancyzk, Amrita George, Derrick Yang, 

Christine Belzyt, Nadine Belitz, Sarah Chaudhry 

Post-Docs 

• Maria H. Morell, Ph.D., J. Matt Velkey, Ph.D., 

Anastasia Yocum, Ph.D. 

Technical Staff 

• Theresa Gratsch, Ph.D, Nancy Leff, Crystal Pacut, 

Marianna Borman

6 


Differences between mouse and human ESC lines 

Much research in the Human Embryonic Stem Cell Core 

laboratory considers differences (and similarities) between 

mouse and human ESC lines. The Core laboratory maintains 

nine of the presidential hESC lines, provides training 

in hESC culture and differentiation, as well as hESC research 

seminar series. 

The Core also provides MEFs, tissue culture reagents, probes, 

antibodies and QC for the membership. Dr. Gratsch has recently 

developed hESC lines in which the pluripotency gene 

Oct4 accurately drives expression of EGFP, so that we can 

monitor in real time the effects of growth factors, extracellular 

matrix, etc., on pluripotency and differentiation. 

Additional indicator transgenic 

lines include one in 

which the Sox3 promoter 

drives EGFP expression, 

so that neural progenitors 

can be sorted. Because 

hESC growth is maintained 

by unknown factors 

secreted by MEFs, 

using microarray 

analysis we identified 

factors produced by 

“bad/old” MEFs that 

might promote hESC 

differentiation. Of 

the 40 genes significantly 

upregulated in 

bad MEFs, Wnt family 

members were identified 7 times; Sfrp1 four times (9.6 

fold). 

Crystal Pacut is developing 

a line of MEFs from hemizygous 

mouse embryos 

that carry the Tcf-Lef-LacZ 

transgene to study Wnt 

signaling in this system. 

Nancy Leff is testing 

bioartificial substrates for 

their ability to support 

undifferentiated growth of 

hESC and managing the 

Core lab. 

Geminin overexpression in hESC expands a 

Sox3+ progenitor population. 


Profile: K. Sue O’Shea, Director, Human Embryonic Stem Cell Core


Honors and Awards: 

Faculty 

F Assistant Professor Cathy Krull’s promotion to 

Associate Professor with tenure has been approved and 

will be effective September 1, 2007. 

F Assistant Professor Billy Tsai successfully competed 

for one of the most prestigious national honors among 

all those conferred upon young faculty in the life sciences: 

the 2006 Burroughs Wellcome Fund Investigators 

in Pathogenesis of Infectious Disease Award. 

F Assistant Professor Ben Novitch was the recipient of a 

March of Dimes Basil O’Connor Award. 

F Assistant Professor Diane Fingar won the American 

Cancer Society Research Scholar Award. 

F Professor Sue O’Shea has been chosen by the NIH to 

be Vice-Chair of the Oversight Organization Committee 

for the National Stem Cell Bank at WiCell. 

F Professor Deborah Gumucio has been named Director 

for the Center of Organogenesis. 

F Professor Kate Barald was the 2006 Sarah Goddard 

Power Award winner and the 2006 Inaugural 

Rackham Graduate Mentoring Award winner for her 

efforts with graduate student mentoring. 

F Professor Mike Welsh has been Editor-in-Chief for the 

Journal of Cell Biology and Toxicology over the past 

four years. 

F Professor Doug Engel is an editor of the journal, 

Molecular and Cellular Biology. 

F Assistant Research Professor Rainer Benndorf was 

invited to speak at both the Flanders Interuniversity 

Institute for Biotechnology, University of Antwerp, Belgium, 

and the Institut de Myologie, Groupe Hospitalier 

Pitie-Salpetriere, Paris, France. His talk was entitled 

“HSP22 and the other small heat shock proteins: 

What goes wrong in (neuron)-muscular disorders?” 

F Associate Professor Sun-Kee Kim was awarded the 

Kaiser Permanente Award for Excellence in Teaching 

in the Preclinical Sciences, the Elizabeth Crosby 

Award for Excellence in Basic Science Teaching, and 

the 2006 Thomas G. Varbedian Award for excellence 

in teaching, service and dedication to medical 

students. 

Research Fellows 

F Stephanie Kadison ( Krull lab) competed 

successfully for the very prestigeous Hartwell 

Foundation Postdoctoral Fellowship 

F Yu-Chi Shen’s (Barald lab) paper in the Journal of Cell 

Science was nominated for a “best paper” award. 

CDB PHOTO GALLERY 

Spring, 2006 - Kellogg Biological Station

8 

Cell & Developmental Biology Faculty List 

Kate F. Barald, Ph.D. 

Professor 

Cell & Developmental Biology 

Associate Director of the Program 

in Biomedical Sciences 

109 Zina Pitcher Place, 3053 BSRB 

Phone: (734) 647-3376 

Email: kfbarald@umich.edu 

Developmental neurobiology, molecular 

neurobiology studies of developing neuronal 

cell and synapses; gene expression in 

the neural crest. 

Scott Barolo, Ph.D. 

Assistant Professor 



Phone (734) 764-7295 

Email: sbarolo@umich.edu 

Mechanisms of transcriptional regulation 

by cell signaling pathways during development. 

Rainer Benndorf, Ph.D. 

Research Assistant Professor 



Phone: (734) 615-5670 

Email: rbenndo@umich.edu 

Interaction of hsp27 with other proteins in 

different organs. 

James Douglas Engel, Ph.D. 

Professor and Chair 



Phone: (734) 615-7509 

Email: engel@umich.edu 

Developmental genetics: use molecular 

genetics to understand the mechanisms 

underlying developmental determination 

during mammalian embryogenesis. 

Diane C. Fingar, Ph.D. 




Phone: (734) 763-7541 

Email: dfingar@umich.edu 

MTOR control of cell growth and size 


Deborah L. Gumucio, Ph.D. 



Director, Center for Organogenesis 


Phone: (734) 647-0172 

Email: dgumucio@umich.edu 

Developmental control of globin gene 

transcription, molecular mechanisms of 

intestinal organogenesis; regulation of acute 

inflammation in familial Mediter. fever. 

Michael Hortsch, Ph.D. 

Associate Professor 



Phone: (734) 647-2720 

Email: hortsch@umich.edu 

Neurogenesis and cell-matrix interactions 

during Drosophila development, cell adhesion 

molecules. 

Catherine Krull, Ph.D. 




Phone: (734) 763-6571 

Email: krullc@umich.edu 

Early patterning decisions in specifying the 

vertebrate limb. 

Kim-Chew Lim, Ph.D. 




Phone: (734) 615-7242 

Email: kclim@umich.edu 

Molecular regulation of the epithelial morphogenesis 

in the developing kidney and 

mammary gland. 

Jiandie Lin, Ph.D. 




Life Science Institute, 5437 

Phone: (734) 615-3512 

Email: jdlin@umich.edu 

Focuses on understanding the transcriptional 

networks that control cellular and 

systemic energy metabolism, and their role 

in the pathogenesis of diseases such as obesity, 

type 2 diabetes and neurodegeneration.


Cell & Developmental Biology Faculty List 

Kentaro Nabeshima, Ph.D. 




Phone: (734) 615-2620 

Email: knabe@umich.edu 

Investigation of mechanisms for the meiotic 

chromosome dynamics using functional 

genomics tools and high-resolution three-dimensional 

microscopy. 

Ben Novitch, Ph.D. 




Phone: (734) 615-1514 

Email: bnovitch@umich.edu 

Patterning of neuronal specificity in the 

vertebrate spinal cord. 

K. Sue O’Shea, Ph.D. 



Director, Human Embryonic Stem Cell Core 


Phone: (734) 763-2550 

Email: oshea@umich.edu 

Very early development of the mammalian 

nervous system. 

Billy Tsai, Ph.D. 




Phone: (734) 763 2547 

Email: btsai@umich.edu 

Interaction between host cell and pathogens. 

Matt Velkey, Ph.D. 

Lecturer III 



Phone: (734) 615-7118 

Email: jvelkey@med.umich.edu 

Medical, dental, and graduate education: 

histology and virtual microscopy. Also 

involved in studies of neurogenesis and cell 

type specification during development and 

regeneration. 

Kristen Verhey, Ph.D. 




Phone: (734) 615-7787 

Email: kjverhey@umich.edu 

Research in the areas of kinesins, a family 

of molecules that are involved in translocation 

of other molecules and organelles along 

microtubules. 

Lois S. Weisman, Ph.D. 



Research Professor 

Life Sciences Institute, 6437 

Phone: ( 734) 647-2539 

Email: lweisman@umich.edu 

Uses the yeast Saccharomyces cerevisiae to 

discover how cell structures are delivered 

to the right place at the right time, which 

informs understanding of embryonic development 

and many diseases including cancer 

and diabetes. 

Michael J. Welsh, Ph.D. 



Research Scientist of Reproductive 

Sciences Program 


Phone: (734) 763-2538 

Email: welsh@umich.edu 

Cell biology of small heat shock proteins. 

Yukiko Yamashita, Ph.D. 





Phone: (734) 615-7692 

Email: yukikomy@umich.edu 

Cellular mechanisms that control stem cell 

behavior, using the Drosophila male germ 

line as a model system.

10 

Richard A. Altschuler, Ph.D. 

Professor and Senior Research Scientist 

Kresge Hearing Research Institute 

Department of Otolaryngology 

6046 KHRI 

Phone: (734) 763-0060 

Email: shuler@umich.edu 

Philip J. Gage, Ph.D. 


Ophthalmology and Visual Sciences 

350 Kellogg Eye Center 

Phone: (734) 647-4215 

Email: philgage@umich.edu 

Jun-Lin Guan, Ph.D. 


Division of Molecular Medicine 

and Genetics 

Department of Internal Medicine 


Phone: (734) 615-4936 

Email: jlguan@umich.edu 

Zhe Han, Ph.D. 



and Genetics 



Phone: (734) 615-5210 

Email: zhan@umich.edu 

Adam (Allan) Beaudoin, Ph.D. 

Susan Brown, Ph.D. 

Alphonse Burdi, Ph.D. 

Bruce Carlson, M.D., Ph.D. 

Graduate Student News: 

Cell & Developmental Biology Joint Faculty 

Peter F. Hitchcock, Ph.D. 


Ophthalmology and Visual Sciences 

418 Kellogg Eye Center 

Phone: (734) 763-8170 

Email: peterh@umich.edu 

Patrick J. Hu, M.D., Ph.D. 





Phone: (734) 615-9656 

Email: pathu@lsi.umich.edu 

Margaret I. Lomax, Ph.D. 

Senior Research Scientist 

Kresge Hearing Research Institute 

Department of Otolaryngology 

9301E MSRB III 

Phone: (734) 647-1893 

Email: mlomax@umich.edu 

Amanda Evans-Zacharias (Gage lab) was selected by the ARVO 

Program Committee to receive the ARVO Foundation for 

Eye Research / Ramon Dacheux, II Memorial Travel Grant. 

Will Zacharias (Gumucio lab) and Alisha Yallowitz (Wellik 

lab) secured prestigious pre-doctoral fellowship positions in 

the Center for Organogenesis Training Grant. 

Nancy Joseph (Morrison lab) defended her thesis entitled “The 

Physiological Function and Regulation of Neural Stem Cells 

in Development and Disease.” She has returned to the 

MSTP program, and was also nominated for an outstanding 

dissertation award. 

Nate Reed’s (Verhey lab) manuscript was featured in in a Current 

Biology Dispatch by J. Chloe Bulinski (17:R18). 


Cell & Developmental Biology Emeritus Faculty 

Walter Castelli, D.D.S. 

A. Kent Christensen, Ph.D. 

Stephen Cinst, Ph.D. 

Peter Coyle, Ph.D. 

Sean J. Morrison, Ph.D. 

Associate Professor 


and Genetics 


Investigator, Howard Hughes 

Medical Institute 

Director, University of Michigan Center 

for Stem Cell Biology 

Henry Sewall Professor in Medicine 


Phone: (734) 647-6261 

Email: seanjm@umich.edu 

Deneen M. Wellik, Ph.D. 


and Genetics 



Phone: (734) 936-8902 

Email: dwellik@umich.edu 

Yuan Zhu, Ph.D. 



and Genetics 



Phone: (734) 647-3033 

Email: yuanzhu@umich.edu 

Pentti Jokelainen, M.D., Ph.D. 

John Lillie, Ph.D. 

Sarah Newman, Ph.D. 

Dawen Cai (Verhey lab) defended his thesis entitled “Biophysical 

Studies of Kinesin-1 (conventional kinesin) in Live Cells.” 

He will be performing his postdoctoral studies in the Verhey 

lab. He also won the award for Best Poster, “Tracking 

of Single Kinesin-1 Motor Molecules in Live Cells” at the 

Biophysical Society Discussions Meeting, Asilomar, CA. 

He was also named Associate Fellow for 2006-2007 by the 

Michigan Society of Fellows, University of Michigan. 

Matt Velkey (O’Shea lab) defended his thesis entitled “Lineage 

Differentiation of Embryonic Stem Cells” and is currently 

the CDB Histology Course Director for medical students, directs 

the Histology course for graduate students and junior 

faculty and will be course director for Dental Histology in 

the Fall. He is continuing his research in the O’Shea lab.



109 Zina Pitcher Place 

3059 BSRB 

Ann Arbor, MI 48109-2200 

med.umich.edu/cdb 

cdbinfo@umich.edu 

Regents of the University: David A. Brandon, Laurence 

B. Deitch, Olivia P. Maynard, Rebecca McGowan, 

Andrea Fischer Newman, Andrew C. Richner, S. Martin 

Taylor, Katherine E. White, Mary Sue Coleman, 

ex officio. 

University of Michigan Non-Discrimination Policy Notice 

The University of Michigan, as an equal opportunity/affirmative action 

employer, complies with all applicable federal and state laws regarding 

nondiscrimination and affirmative action, including Title IX of the 

Education Amendments of 1972 and Section 504 of the Rehabilitation 

Act of 1973. The University of Michigan is committed to a policy of 

nondiscrimination and equal opportunity for all persons regardless of race, 

sex*, color, religion, creed, national origin or ancestry, age, marital status, 

sexual orientation, disability, or Vietnam-era veteran status in employment, 

educational programs and activities, and admissions. Inquiries or complaints 

may be addressed to the Senior Director for Institutional Equity 

and Title IX/Section 504 Coordinator, Office for Institutional Equity, 2072 

Administrative Services Building, Ann Arbor, Michigan 48109-1432, 

734-763-0235, TTY 734-647-1388. For other University of Michigan 

information call 734-764-1817. 

Got something to add? 

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Please take a moment to complete the attached card and return it to us, or email your 

responses to cdbinfo@umich.edu. We look forward to hearing from you and sending 

you future updates about the Department, faculty, alumni and classmates. 

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