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DIETRICH BÜSSELBERG, PH.D.
PUBLICATIONS
UPDATED MARCH 2012
PEER REVIEWED ARTICLES
1. Büsselberg D, Evans ML, Rahmann H, Carpenter DO. Effects of exogenous
gangliosides and cholesterol application of Aplysia neurons. Memb Biochem, 1989, 8:19-
26.
2. Büsselberg D, Carpenter DO, Sugita M, Araki S, Satake M, Rahmann H. Effects of
exogenous lipid on excitability of Aplysia neurons. Biomedical Research, 1990, 11 (2):77-
86.
3. Büsselberg D, Evans ML, Rahmann H, Carpenter DO. Lead inhibits the voltage
activated calcium current of Aplysia neurons. Toxicology letters, 1990, 51:51-57.
4. Büsselberg D, Evans ML, Rahmann H, Carpenter DO. Zn 2+ blocks the voltage activated
calcium current of Aplysia neurons and changes its kinetics. Neuroscience letters, 1990,
117-122.
5. Büsselberg D, Evans M L, Rahmann H, Carpenter DO. Effects of inorganic and
triethyllead and inorganic mercury on the voltage activated calcium channel of Aplysia
neurons. Neurotoxicology, 1991, 12:733-744.
6. Büsselberg D, Evans M L, Rahmann H, Carpenter DO. Lead and Zinc block a voltage
activated calcium channel of Aplysia neurons. J Neurophysiology, 1991, 65(4): 786-795.
7. Schönrock B, Büsselberg D, Haas H L. Properties of tuberomammillary hista-mine
neurones and their response to galanin. Agents and Actions, 1991, 33, ½:135-137.
8. Evans M L, Büsselberg D, Carpenter D O. Lead blocks the calcium current of cultured
dorsal root ganglion cells. Neuroscience letters, 1991, 129:103-106.
9. Büsselberg D, Michael D, Evans M L, Carpenter DO, Haas HL. Zinc (Zn 2+ ) blocks
voltage gated calcium channels in cultured rat dorsal root ganglion cells. Brain Res.,
1992, 593:77-81.
10. Büsselberg D, Evans M L, Haas H L, Carpenter DO. Blockade of mammalian and
invertebrate calcium channels by lead Neurotoxicology, 1993, 14:249-258.
11. Hori N, Büsselberg D, Matthews R, Parson P, Carpenter DO. Lead blocks LTP by an
action not at NMDA receptors. J Experimental Neurology, 1993, 119:192-197.
12. Uteshev V, Büsselberg D, Haas H L. Pb 2+ modulates the NMDA-receptor-channel
complex. Naunyn Schmiedebergs Archiv of Pharmacology, 1993, 347:209-213.
13. Büsselberg D, Platt B, Haas H L, Carpenter DO. Voltage-gated calcium channel
currents of rat dorsal root ganglion (DRG) cells are blocked by Al 3+ . Brain Res. 1993,
622:163-168.
14. Büsselberg D, Platt B, Michael D, Carpenter DO, Haas HL. Mammalian voltage
activated calcium channel currents are blocked by Pb 2+ , Zn 2+ and Al 2+ . J Neurophysiology
1994, 71: 1491-1497.
15. Pekel M, Platt B, Büsselberg D. Effects of mercury (Hg 2+ ) on voltage activated calcium
channel currents in Aplysia and cultured rat neurons. Brain Res. 1993, 632: 121-126.
16. Platt B, Haas H, Büsselberg D. Extracellular pH modulates aluminum-blockade of
mammalian voltage-activated calcium channel currents. NeuroReport 1993, 4: 1251-
1254.
DIETRICH BÜSSELBERG, PH.D.
PUBLICATIONS - 1

17. Platt B, Büsselberg D. Combined actions of Pb 2+ , Zn 2+ and Al 2+ on voltage activated
calcium channel currents. Cell Molec. NeurobioL 1994, 14: 831-840. IF:
18. Platt B, Büsselberg D. Actions of aluminum on voltage activated calcium channel
currents. Cell Molec. Neurobiol 1994, 14: 819-829.
19. Büsselberg D, Michael D, Platt B. Pb 2+ reduces voltage- and NMDA-activated calcium
channel currents. Cell Molec. Neurobiol 1994, 14: 711-722.
20. Büsselberg D, Pekel M, Michael D, Platt B. Mercury (Hg 2+ ) and zinc (Zn 2+ ): Two
divalent cations with different actions at voltage activated calcium channel currents. Cell
Molec. NeurobioL 1994, 14: 675-687.
21. Platt B, Haas H, Büsselberg D. Aluminum reduces glutamate-activated currents of rat
hippocampal neurons. NeuroReport, 1994, 5: 2329-2332.
22. Platt, B, Carpenter, DO, Büsselberg, D, Reymann, KG. and G. Riedel Aluminum impairs
hippocampal long-term potentiation in rats in vitro and in vivo Exp Neurol 1995, 134: 1-
14. IF: 4.156
23. Leonhardt R, Pekel M, Platt B, Haas HL, Büsselberg D. Voltage-activated calcium
channel currents of rat DRG neurons are reduced by mercuric chloride (HgCl2) and
methylmercury (CH3HgCl). Neurotoxicology 1996, 17/1: 85-91.
24. Leonhardt R, Haas HL, Büsselberg D. Voltage gated calcium, potassium and sodium
channel currents of rat DRG neurons are reduced by methylmercury. Naunyn
Schmiedebergs Archievs of Pharmacology 1996, 354/4: 532-538.
25. Büsselberg D. Calcium channels as target sites of heavy metals. Toxicology letters 1995,
82/83: 255-262.
26. Büsselberg D. Actions of lead on neuronal membrane currents and synaptic plasticity.
Metal Ions in Biology and Medicine 1996, 4: 241-243.
27. Leonhardt R, Pekel M, Platt B, Haas HL, Büsselberg D. Mercury compounds reduce
voltage activated ion channel currents. Metal Ions in Biology and Medicine 1996, 4: 204-
206.
28. Domann R, Wunder L, Büsselberg D. Lead reduces calcium entry after depo-larisation
without passing the cell membrane in cultured DRG neurons: FURA-2 meas-urements.
Cell Molec. Neurobiol 1997, 17/3: 305-314.
29. Kirschstein T, Büsselberg D, Treede RD. Coexpression of heat-evoked inward currents
in acutely dissociated rat dorsal root ganglion neurons. Neurosci. Lett. 1997, 231: 1-4.
30. Gawrisch E, Leonhardt R, Büsselberg D. Voltage-activated calcium channel currents of
rat dorsal root ganglion cells are reduced by trimethyl lead Toxicology letters 1997, 92:
117-122.
31. Diewald L, Heimrich B, Büsselberg D, Watanabe T, Haas HL. Histaminergic system in
co-cultures of hippocampus and posterior hypothalamus: a morphological and
electrophysiological study in the rat. Europ J Neuroscience 1997, 9: 2406-2413.
32. Schirrmacher K, Wiemann M, Bingmann D, Büsselberg D. Effects of lead, mercury and
methly mercury on gap junctions and [Ca 2+ ]i in bone cells. Calcified Tissue Int 1998,
63:134-139.
33. Büsselberg D, Schirrmacher K, Domann R, Wiemann M. Lead interferes with calcium
entry through Membrane pores. Fresenius´ J Analyt. Chem 1998, 361: 372-376.
34. Wiemann M, Büsselberg D, Schirrmacher K, Bingmann D. A calcium release activated
calcium influx in primary cultures of rat osteoblast-like cells. Calcified Tissue Int. 1998,
63: 154-159.
DIETRICH BÜSSELBERG, PH.D.
PUBLICATIONS - 2

35. Schirrmacher K, Büsselberg D, Langosch JM, Bingmann D. Effects of (±)-kavain on
voltage-activated inward currents of dorsal root ganglion cells from neonatal rats. Europ
Neuropsycopharmacol 1999, 9: 171-176.
36. Kirschstein T, Greffrath W, Büsselberg D, Treede R-D. Inhibition of rapid heat
responses in nociceptive primary sensory neurones of the rat by vanilloid receptor
antagonists. J Neurophysiol 1999, 82: 2853-2860.
37. Wiemann M, Schirrmacher K, Büsselberg D. Interference of lead with the cal-cium
release activated calcium flux of osteoblast-like cells. Calcified Tissue Int. 1999, 65:479-
485.
38. Richter DW, Mironov SI, Büsselberg D, Lalley PM, Bischoff AM, Wilken B. Respiratory
rhythm generation: plasticity of a neuronal network Neuroscientist 2000, 6(3):181-198.
39. Schwarz S, Greffrath W, Büsselberg D, Treede R-D. Inactivation and tachy-phylaxis of
heat-evoked inward currents in nociceptive primary sensory neurones in rats. J Physiol
(Lond) 2000, 528 (3): 539-549.
40. Büsselberg D, Bischoff AM, Paton, JFR, Richter DW. Reorganisation of the respiratory
network after loss of glycinergic inhibition. Pflügers Archiv, Eup J Physiol 2001,441: 444-
449.
41. Büsselberg D, Bischoff, AM, Becker, K, Becker, C.-M, Richter DW. Respiratory rhythm
in mutant oscillator mice (Glra 1spd-ot / Glra 1spd-ot). Neurosci. Lett. 2001,316/2: 99-
102.
42. Dutschmann M, Bischoff AM, Richter DW, Büsselberg D. Histaminergic Modulation
of the respiratory network via H1, H2 and H3 receptors analysed in an in situ mouse.
Pflügers Archiv, Eup J Physiol 2003, 445: 570-576.
43. Mohanakumar KP, Samanta Ray S, Büsselberg D. The parkinsonian neuro-toxin 1methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine
on membrane currents and intrasynaptosomal
calcium. Neuroscience Research Communications 2002, 30/1: 35-42.
44. Büsselberg D, Bischoff AM, Richter D W. Failure of glycine inhibition changes bursting
behaviour of respiratory neurones. Neuroscience 2003, 122/3: 831-841.
45. Splettstoesser F, Bonnet U, Wiemann M, Bingmann, D, Büsselberg D. Modulation of
voltage gated channel currents by Harman and Harmaline Brit. J Phar-macoL 2005, 144:
52-58.
46. Florea A-M, Dopp E, Büsselberg D. Elevated calcium transients by trimehtyltin
chloride in HeLa cells: types and levels of elevation. Cell Calcium 2005, 37: 251-258.
47. Florea A-M, Büsselberg D. Toxic effects of metals: modulation of intracellular calcium
homeostasis. Materialwissenschaft und Werkstofftechnik 2005, 36: 757-760.
48. Hagenacker T, Splettstoesser F, Greffrath W, Treede, R-D, Büsselberg D. Capsaicin
blocks voltage-gated calcium channel currents of small DRG neurones. Brain Research
2005, 1062: 74-85.
49. Florea A-M, Splettstoesser, F, Dopp, E, Rettenmeier AW, Büsselberg D.Modulation of
calcium homeostasis by trimehtyltin chloride in human tumor cells: Neuroblastoma
SY5Y and cervix adenocarcinoma Hela S3. Toxicology. 2005, 216: 1-8.
50. Florea A-M, Büsselberg D. Metals and metal compounds: occurrence, use, benefits and
toxic cellular effects. Biometals 2006, 19: 419-427.
51. Tomaszewski A, Büsselberg D. Cisplatin modulates voltage gated channels in dorsal
root ganglion neurones. Neurotoxicology 2007, 28: 49-58.
DIETRICH BÜSSELBERG, PH.D.
PUBLICATIONS - 3

52. Florea A-M, Splettstoesser F, Büsselberg D. Mechanisms of arsenic trioxide (As2O3)
induced calcium signals and cellular death in two human SY-5Y Neuroblastoma and 293
embryonic kidney (HEK) cells. TAAP 2007, 220: 292-301.
53. Splettstoesser F, Florea A-M, Büsselberg D. IP3-receptor-antagonist 2-APB attenuates
cisplatin induced Ca 2+- influx in HeLa-S3 cells and prevents activation of calpain. Brit. J
Pharmacology 2007, 151: 1176-1186.
54. Hagenacker T, Büsselberg D. Modulation of intracellular calcium [Ca 2+ ]i influences
capsaicin induced currents of TRPV-1 and voltage activated channel currents in
nociceptive neurones. J Pheripheral Nervous System 2007, 12:277-284.
55. Hagenacker T, Ledwig D, Büsselberg D. Intracellular calcium ([Ca 2+ ]i) influences pain
sensation in peripheral nociceptive systems. Cell Calcium 2008, 43: 215-227.
56. Czeschik JC, Hagenacker T, Schäfers M, Büsselberg D. TNF- differentially modulates
ion channels of nociceptive neurons. Neuroscience Letters 2008, 434: 293-298.
57. Florea A-M, Büsselberg D. Arsenic trioxide in environmentally and clinically relevant
concentrations alters calcium homeostasis and induces cell type specific apoptosis in
tumour and non tumor cells. Toxicology letters 2008, 179: 34-42.
58. Tomaszewski A, Büsselberg D. SnCl2 reduces voltage gated calcium channel currents of
dorsal root ganglion neurones of rats. Neurotoxicology 2008, 29: 958-963.
59. Florea A-M, Büsselberg, D. Metal compounds elevate intracellular calcium by different
mechanism inducing cell death in “in vitro” systems. Mat.-wiss. und Werkstofftechnik
2009, 40: 13-16.
60. Günes DA, Florea A-M Splettstoesser F, Büsselberg D. Co-application of arsenic
trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has
differential effects on the intracellular calcium concentration ([Ca 2+ ]i) and cytotoxicity.
Neurotoxicology 2009, 30(2): 194-202.
61. Florea A-M, Büsselberg D. Anti-Cancer drugs interfere with calcium signaling.
Neurotoxicology 2009, 30(5): 803-810.
62. Greffrath W, Schwarz St T, Büsselberg D, Treede R-D. Heat-evoked action potential
discharges in nociceptive primary sensory neurons of rats. J Neurophysiology, 2009,
102(1):424-436.
63. Hagenacker T, Czschik JC, Schäfers M, Büsselberg D. Sensitization of voltage activated
calcium channel currents for capsaicin in nociceptive neurons by tumor necrosis factor
alpha. Brain Research Bulletin, 2010, 81(1): 157-163.
64. Hagenacker T, Hillebrand I, Wissmann A, Büsselberg D, Schäfers M. Anti-allodynic
effect of the flavonoid myricetin in a rat model of neuropathic pain: Involvement of p38
and protein kinase C mediated modulation of Ca²+ channels. Eur J Pain. 2010;
14(10):992-8. Epub 2010 May 14.
65. Hagenacker T, Hillebrand I, Büsselberg D, Schäfers M. Myricetin reduces voltage
activated potassium channel currents in DRG neurons by a p38 dependent mechanism.
Brain Res Bull. 2010; 83(5):292-6.
66. Hagenacker T, Ledwig D, Büsselberg D. Additive inhibitory effects of calcitonin and
capsaicin on voltage activated calcium channel currents in nociceptive neurones of rat.
Brain Res Bull. 2011 Feb 16. [Epub ahead of print]
67. Florea A-M, Büsselberg D. Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of
Activity, Drug Resistance and Induced Side Effects. Review: Cancers 2011, 3(1), 1351-
1371; doi:10.3390/cancers3011351
68. Florea A-M, Büsselberg D. Metals and Breast Cancer: Risk Factors or Healing Agents?
Review: Journal of Toxicology. 2011:159619.
DIETRICH BÜSSELBERG, PH.D.
PUBLICATIONS - 4

69. Sadiq S, Ghazala Z, Chowdhury A, Büsselberg D. Metal toxicity at the synapse:
presynaptic, postsynaptic and long-term effects. Journal of Toxicology. 2012:132671.
70. Florea A-M, Büsselberg D, Carpenter DO. Metals and Disease. Journal of Toxicology
(editorial), (in print)
BOOKS/BOOK CHAPTERS
1. Haas H L, Büsselberg D. Recording Chambers - Slices. In: Practical electrophysiological
methods. A guide for in vitro studies in vertebrate neurobiology;
Kettenmann, H. and Grantyn R. (Eds.), Wiley-Liss, New York, 1992, p. 16-19.
2. Büsselberg D. Bleiwirkungen auf neuronale Membranströme und synaptische
Plastizität. Habilitationsschrift; Verlag Dr. Köster, Berlin; ISBN 3-89574-064-0;
1995.
3. Haas H L, Büsselberg D. Neurotoxikologie in vitro mit Hilfe der
Elektrophysiologie. In: Ersatz- und Ergänzungsmethoden zu Tierversuchen;
Schöffl, H., Spielmann, H. und Tritthart, H.A., Springer, Wien, New York, 1996,
65-69.
4. Büsselberg D. Blei reduziert Gedächtnisleistungen: historische und aktuelle
Aspekte; Stand der Forschung. In: Kulturring, Jahresberichte, 1996, 73:18-20.
5. Büsselberg D. Actions of Metals on Membrane Channels, Calcium Homeostasis
and Synaptic Plastivity. In: Organometal and Metalloid Specism in the
Environment: Analysis, Distribution, Processes and Toxicological Evaluation; A.
V. Hirner & H. Emons (Eds.), Springer, Wien, New York, 2004, 259-281.
6. Hagenacker T, Splettstoesser F, Büsselberg D. Pain modulation by voltage gated
calcium channels. In: Neuro-Visionen 2; K.-A. Hossmann (Ed.), Verlag Ferdinand
Schöningh, Paderborn, München, Wien, Zürich, 2005, 145-146.
7. Juntermanns B, Göpelt K, Splettstoesser F, Büsselberg D. The respiratory
rhythm changes under blockade of gap junctions. In: Neuro-Visionen 2; K.-A.
Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien,
Zürich, 2005, 51-53.
8. Florea A-M, Splettstoesser F, Dopp E, Rettenmeier A W, Büsselberg D. The
environmentally relevant trimethyltin (TMT) influences calcium homeostasis in
ex-citable and non-excitable cell systems. In: Neuro-Visionen 2; K.-A. Hossmann
(Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2005,
23-25.
9. Mock E P, Göpelt K, Büsselberg D. Calcium channel modulators influence
breathing. In: Neuro-Visionen 3; K.-A. Hossmann (Ed.), Verlag Ferdinand
Schöningh, Paderborn, München, Wien, Zürich, 2006, 32-33.
10. Florea A-M, Splettstoesser F, Tomaszewski A, Büsselberg D. Anti cancer drugs
(As2O3 and cis-platin) interfere with calcium signals in in tumour cells. In: Neuro-
Visionen 3; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn,
München, Wien, Zürich, 2006, 34-36.
11. Neuendorf A, Hagenacker T, Büsselberg D. Differential modulation of voltage
gated channels by capsaicin. In: Neuro-Visionen 3; K.-A. Hossmann (Ed.), Verlag
Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2006, 99-100.
DIETRICH BÜSSELBERG, PH.D.
PUBLICATIONS - 5

12. Günes DA, Florea A-M, Splettstoesser F, Kunz I, Büsselberg D. Anti-cancer
drugs elevate intracellular calcium by different mechanisms. In: Neuro-Visionen
4; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München,
Wien, Zürich, 2007, 35-36.
13. Hagenacker T, Ledwig D, Neuendorf A, Czeschik C, Schäfers M, Büsselberg D.
New pharmaceutic interventions in the therapy of chronic pain. In: Neuro-
Visionen 4; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn,
München, Wien, Zürich, 2007, 133-135.
14. Mock E P, Juntermanns B, Göpelt K, Büsselberg D. Various „drugs“ influence
the respiratory rhythm. In: Neuro-Visionen 4; K.-A. Hossmann (Ed.), Verlag
Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2007, 39-40.
15. Florea A-M, Büsselberg D. Calcium ([Ca 2+ ]i ) Signaling as a Key-Target for
Cancer Treatment. In: Calcium Signaling ISBN: 978-1-61324-313-8 Editor:
Masayoshi Yamaguchi, ©2011 Nova Science Publishers, Inc. (in press)
DIETRICH BÜSSELBERG, PH.D.
PUBLICATIONS - 6