Pathology and Laboratory Medicine Annual Report 2005-2006
Pathology and Laboratory Medicine Annual Report 2005-2006
Pathology and Laboratory Medicine Annual Report 2005-2006
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Table of Contents<br />
INTRODUCTION & OVERVIEW <strong>2005</strong>-<strong>2006</strong> 4<br />
HONOURS/AWARDS/APPOINTMENTS 6<br />
Appointments 6<br />
Awards 7<br />
CLINICAL SERVICES 8<br />
Patient Services 8<br />
Clinical Biochemistry 8<br />
Hematopathology & Blood Transfusion 9<br />
Rapid Response <strong>Laboratory</strong> 9<br />
<strong>Pathology</strong> 10<br />
<strong>Laboratory</strong> Genetics 11<br />
Andrology 12<br />
LABORATORY INFORMATICS 13<br />
<strong>Laboratory</strong> Information System 13<br />
Exp<strong>and</strong>ed Interfaces 13<br />
Citrix Support 13<br />
Web Site/Communications 13<br />
Paradigm Document Control System 14<br />
Digital Imaging 14<br />
RENOVATIONS & RELOCATIONS 15<br />
QUALITY PROGRAMS 16<br />
Accreditations, Regulatory Certifications/Registrations 16<br />
External Quality Assessment Programs 17<br />
Continuous Quality Improvement Activities: Indicators 18<br />
Quality Management Team Activities: <strong>2005</strong>-<strong>2006</strong> 18<br />
EDUCATION 19<br />
Educational Activities July <strong>2005</strong> – June <strong>2006</strong> 19<br />
Education Committee 19<br />
Medical Education 19<br />
Research Student Programs 24<br />
Technical Education 25<br />
SPONSORED RESEARCH AND INNOVATION 27<br />
PRESENTATIONS & ABSTRACTS July 1, <strong>2005</strong> – June 30, <strong>2006</strong> 32<br />
SCIENTIFIC PAPERS July 1, <strong>2005</strong> – June 30, <strong>2006</strong> 50<br />
BOOKS & BOOK CHAPTERS 69<br />
APPENDIX A - Medical <strong>and</strong> Scientific Staff as at June 30, <strong>2006</strong> 71<br />
APPENDIX B - Technical & Support Staff as at June 30, <strong>2005</strong> 73<br />
APPENDIX C - Technical & Support Staff Changes 75<br />
APPENDIX D - Residents 76<br />
APPENDIX E - Fellows 77<br />
APPENDIX F - Graduate Students <strong>2005</strong>-<strong>2006</strong> 78<br />
APPENDIX G - Post Doctoral Students 81<br />
APPENDIX H - Summer Students May – August <strong>2005</strong> 82<br />
APPENDIX I - <strong>Report</strong>able Tests 83<br />
APPENDIX J - External Service Linkages 85<br />
APPENDIX K - April <strong>2006</strong> Departmental Rounds 86
INTRODUCTION & OVERVIEW <strong>2005</strong>-<strong>2006</strong><br />
Over the past year, there have been two major changes<br />
related to <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>, the<br />
establishment of <strong>Laboratory</strong> <strong>Medicine</strong> <strong>and</strong> Infection Control<br />
as a Mount Sinai Hospital Centre of Excellence, <strong>and</strong> the<br />
establishment of MOUNT SINAI SERVICES, the commercial<br />
vehicle for <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> <strong>and</strong> Medical<br />
Microbiology.<br />
Mount Sinai Hospital is in the midst of substantial<br />
expansion <strong>and</strong> transformational change. The Toronto<br />
Centre for Phenogenomics <strong>and</strong> the Samuel Lunenfeld<br />
Research Institute expansion at 11 Orde Street are under<br />
construction <strong>and</strong> will soon be operational. Mount Sinai<br />
has also received permission <strong>and</strong> funding from the Ontario<br />
government towards building a patient care obstetrics<br />
facility, an ambulatory surgery centre <strong>and</strong> refurbishing<br />
its facilities. As well, the hospital has established a new<br />
strategic plan. This new strategic plan includes five clinical<br />
centres of excellence: Women’s <strong>and</strong> Infant’s Health,<br />
Chronic diseases (medicine), Surgical specialties <strong>and</strong><br />
Oncology, the Samuel Lunenfeld Research Institute, <strong>and</strong><br />
most notably, <strong>Laboratory</strong> <strong>Medicine</strong> <strong>and</strong> Infection Control.<br />
The establishment of <strong>Laboratory</strong> <strong>Medicine</strong> <strong>and</strong> Infection<br />
Control as a Centre of Excellence acknowledges the<br />
strengths <strong>and</strong> stature of both <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong><br />
<strong>Medicine</strong> <strong>and</strong> Medical Microbiology not only at Mount Sinai<br />
Hospital but in the external community. That <strong>Laboratory</strong><br />
<strong>Medicine</strong> <strong>and</strong> Infection Control is considered a Centre<br />
of Excellence is a major opportunity for the laboratories<br />
at Mount Sinai Hospital, as this is a virtually unique<br />
organizational structure in Canadian health care.<br />
For many years, <strong>Pathology</strong> & <strong>Laboratory</strong> <strong>Medicine</strong> has<br />
served clients beyond Mount Sinai. These clients include<br />
other hospitals but also pharma <strong>and</strong> medical device<br />
corporations in the private sector. This commercial activity<br />
has brought many benefits including connectivity to the<br />
community <strong>and</strong> access to advanced technology from<br />
around the world to Mount Sinai Hospital. In recognition<br />
of these benefits, a new company, MOUNT SINAI SERVICES,<br />
has been established to exp<strong>and</strong> future commercial<br />
opportunities related to diagnostics.
This year, a substantial boost to laboratory services<br />
infrastructure at Mount Sinai Hospital was the award<br />
of $1,248,000 of federal/provincial Designated Medical<br />
Equipment funding to laboratory services. For <strong>Pathology</strong><br />
<strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> this has facilitated several<br />
important initiatives including an automated blood bank<br />
system, renewal of our coagulation system, <strong>and</strong> flow<br />
cytometer, <strong>and</strong> the establishment of more automated<br />
histologic processing technology.<br />
Over the past year, our collaborative activity with the<br />
Hospital for Sick Children has increased greatly. These<br />
collaborations include perinatal pathology, <strong>and</strong> genetics.<br />
A notable clinical development has been the establishment<br />
of the Fred Litwin Clinical Genetics Centre which will<br />
amplify Mount Sinai’s strength in clinical genetics. This is<br />
accompanied by further outreach of our laboratory genetics<br />
services including a collaborative program with Lakeridge<br />
Health Centre.<br />
We welcome Dr. Patrick Shannon to our staff. Dr.<br />
Shannon is a neuropathologist with a special interest in<br />
developmental perinatology. Dr. Shannon will join Dr.<br />
Sarah Keating <strong>and</strong> Dr. S<strong>and</strong>ra Viero in building the regional<br />
program in Fetal <strong>and</strong> Perinatal <strong>Pathology</strong>.<br />
All of us were deeply saddened by the death of our<br />
beloved colleague, Dr. Yvan Bédard. Yvan was widely<br />
regarded as one of Canada’s most outst<strong>and</strong>ing diagnostic<br />
cytopathologists <strong>and</strong> pathology educators. In his career<br />
at Mount Sinai Hospital spanning 34 years, Dr. Bédard<br />
educated over 60 residents <strong>and</strong> fellows in cytopathology.<br />
The advancement of <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong><br />
at Mount Sinai Hospital is highly dependent on expertise<br />
of both our medical/scientific <strong>and</strong> support staff <strong>and</strong> their<br />
capacity to work together towards the common goals<br />
of enhancing health care, education <strong>and</strong> research. We<br />
acknowledge their continuing contributions with gratitude<br />
<strong>and</strong> pride. Once again, we thank the administration of<br />
Mount Sinai Hospital led by Joseph Mapa for continuing<br />
support <strong>and</strong> encouragement of all our endeavours.
HONOURS/AWARDS/APPOINTMENTS<br />
Appointments<br />
Dr. Yvan Bédard, Head of Cytopathology <strong>and</strong> Electron Microscopy, <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>, has been<br />
selected as the <strong>2006</strong> recipient of the <strong>Laboratory</strong> <strong>Medicine</strong> <strong>and</strong> Pathobiology, University of Toronto, Distinguished<br />
Service Award. This award honours Dr. Bédard’s 34 years of leadership in teaching <strong>and</strong> innovative service related<br />
to Cytopathology <strong>and</strong> Electron Microscopy, as well as his local <strong>and</strong> national contributions in the advancement of<br />
resident education.<br />
Dr. Terry Colgan has been appointed Section Editor for Cytopathology, Archives of <strong>Pathology</strong> & <strong>Laboratory</strong><br />
<strong>Medicine</strong>.<br />
Dr. Terry Colgan has been appointed Co-Chair, Toronto Regional Co-coordinating<br />
Committee, (for <strong>Laboratory</strong> Reform), Ministry of Health <strong>and</strong> Long Term Care,<br />
Province of Ontario. As well, Dr. Colgan has been appointed Academic Representative<br />
to the <strong>Laboratory</strong> <strong>Medicine</strong> Funding Implementation Committee (LMFIC) of the Ministry<br />
of Health <strong>and</strong> Long Term Care, Ontario, <strong>and</strong> the Ontario Medical Association.<br />
Dr. Terry Colgan has been appointed External reviewer, Division of Anatomical<br />
<strong>Pathology</strong>, Ottawa University.<br />
Dr. Eleftherios Diam<strong>and</strong>is has extended his clinical biochemistry administration responsibilities with his appointment<br />
as Biochemist-in-Chief at the University Health Network.<br />
Dr. Eleftherios was appointed as Associate Member, Samuel Lunenfeld Research Institute.<br />
Dr. Eleftherios Diam<strong>and</strong>is has been appointed to the Editorial Board of Clinical Proteomics.<br />
Dr. Marc Grynpas has been appointed as a scientific officer to the Canadian Institute of Health Research, Clinical<br />
Investigation Grant Panel.<br />
Dr. Marc Grynpas has been appointed a member of the Editorial Board, Calcified Tissue International.<br />
Mr. Gaman Modi has been appointed as a member of the Board of Directors to the Ontario Safety Association for<br />
Community & Healthcare for a 3 year term from <strong>2005</strong> to 2008. As well, Mr. Modi has been appointed as Vice<br />
Chair to the Advisory Board of the Ontario <strong>Laboratory</strong> Accreditation Program, QMP-LS, <strong>2005</strong>-<strong>2006</strong> <strong>and</strong> has been<br />
re-appointed to the Scientific Advisory Panel for the Canadian Journal of Medical <strong>Laboratory</strong> Science, <strong>2005</strong>-<strong>2006</strong>.
Awards<br />
Dr. Anita Bane received the Irish-North American Association of Pathologists’ award, for her platform presentation<br />
”BRCA2 associated breast cancers exhibit a luminal phenotype despite their high histologic grade” at the United<br />
States <strong>and</strong> Canadian Academy of <strong>Pathology</strong> Meeting, Atlanta, <strong>2006</strong>.<br />
Dr. Eleftherios Diam<strong>and</strong>is was awarded the Frey-Werle commemorative gold medal from the Frey-Werle Foundation,<br />
Australia, <strong>2006</strong>.<br />
Dr. Valérie Dubé, Clinical Fellow, supervised by Dr. Terry Colgan received the Best Platform Presentation Award at the<br />
<strong>Annual</strong> U of T Department of Obstetrics <strong>and</strong> Gynecology Research Day in May <strong>2006</strong>, for an oral presentation of her<br />
paper: “The Toronto Endometrial Proteomic Initiative: towards discovery of new endometrial cancer biomarkers”.<br />
Dr. Mock received a scholastic teaching award from the Alpha Omega fraternity, Toronto, <strong>2006</strong>.<br />
Dr. Anne Marie Mulligan, Clinical Fellow, supervised by Dr. Frances O’Malley has been selected as a faculty member<br />
for the Toronto Breast Day Continuing Education Program.<br />
Dr. Kenneth Pritzker was the recipient of the Karen McGibbon Award of Excellence together with Mount Sinai<br />
Hospital Network of Knowledge Team affiliated with the Peter Silverman Centre for International Health, <strong>2005</strong>.<br />
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CLINICAL SERVICES<br />
Patient Services<br />
Patient Services is one of Mount Sinai’s front doors with over 90,000 patients seen each year by our dedicated staff.<br />
Over the year, space was secured <strong>and</strong> plans were advanced for enlarging our ambulatory care laboratory at 700<br />
University Avenue.<br />
Clinical Biochemistry<br />
Maternal Serum Screening Program:<br />
The Program continued to grow in size <strong>and</strong> complexity with the addition of a new biomarker inhibin A, conversion<br />
of the triple screen to the quadruple version, generation of first trimester Trisomy 18 <strong>and</strong> 13 risk, <strong>and</strong><br />
introduction of the first <strong>and</strong> second trimester integrated screen option.<br />
The ability of the screens to predict better Downs’ Syndrome <strong>and</strong> other Trisomies was demonstrated after<br />
linking screen risks to the karyotype outcome in the Cytogenetics database.<br />
In Vitro Fertilization<br />
Hormone testing was consolidated on the new Roche Modular automated analyzer, thereby simplifying specimen<br />
h<strong>and</strong>ling <strong>and</strong> facilitating rapid delivery of test results to the clinical service monitoring progress of the<br />
developing follicle.<br />
Reference Ranges<br />
With medical leadership from Dr. Irv Bromberg, the Division of Clinical Biochemistry is continuing its efforts to<br />
establish meaningful reference ranges for all analytes. Significant progress on this project has been made <strong>and</strong><br />
approximately 100 normal volunteers are now participating. We are currently in the stage of analyzing the<br />
distributions for deriving reference ranges. We are also participating in a similar effort, initiated by the College<br />
of American Pathologists.
Hematopathology & Blood Transfusion<br />
A new high speed flow cytometry cell sorter “BD FACSAria” was acquired. This will facilitate the research on<br />
hemopoietic stem cells under the guidance of Dr. Wang.<br />
Mr. Shahcheraghi successfully completed his MSc on the pathophysiology of anti-K haemolytic disease of the<br />
newborn under the supervision of Dr. Denomme.<br />
Dr. J. Pendergrast successfully completed the Royal College fellowship in Transfusion <strong>Medicine</strong>.<br />
Dr. Hamid Jahanmahar is continuing his sabbatical working on computerized image analysis of malignant<br />
lymphocytes. Dr. Jahanmahar is from Tehran University of <strong>Medicine</strong> Sciences, <strong>and</strong> assistant professor <strong>and</strong> director of<br />
Hematology <strong>Laboratory</strong> in the Department of Clinical <strong>Laboratory</strong> Sciences.<br />
Rapid Response <strong>Laboratory</strong><br />
This past year saw one of the biggest changes to date.<br />
Newly acquired space was completely renovated to suit the needs of the biochemistry section. New supply cabinets<br />
were built to specifically store the daily supplies required in the RRL. Items are clearly labeled <strong>and</strong> displayed resulting<br />
in improved inventory control <strong>and</strong> management.<br />
The entire middle section of the lab was renovated to accommodate the new Roche Modular platform which<br />
went into operation in September. This system revolutionized how chemistry samples are now processed in that it<br />
integrates all three phases – pre-analytics, analytics <strong>and</strong> post – analytics. The introduction of this system ensures<br />
improved turnaround time for results reporting, less blood drawn on patients, backup <strong>and</strong> expansion capabilities.<br />
The Roche Modular Analytical <strong>and</strong> Pre-Analytical Systems are now fully integrated into the clinical service <strong>and</strong> they<br />
perform well. Additional analytical capabilities are realized by implementing automated ELISA platforms for specialty<br />
testing <strong>and</strong> maternal serum screening programs.<br />
The RRL was fortunate to also acquire additional equipment through the DME funding process. New coagulation<br />
equipment is now operational <strong>and</strong> promises to be more cost effective <strong>and</strong> improve turn around times for results<br />
reporting.<br />
The transfusion medicine laboratory is seeing automation for the first time with the purchase of the Galileo Automated<br />
System, .scheduled to be implemented in November.<br />
A new protein <strong>and</strong> urine electrophoresis analyzer introduced in May <strong>2006</strong> is more cost effective, more user friendly<br />
<strong>and</strong> has cut down dramatically the time for results reporting.<br />
The Auto Delphia replaces other platforms used for Prenatal Screening Testing <strong>and</strong> the NexGen has the ability to<br />
automate some of our more labour intensive testing.<br />
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<strong>Pathology</strong><br />
A major thrust of activity in anatomical pathology was progress towards incorporation of synoptic reporting into<br />
surgical pathology reports. As well, there were trends toward increased utilization of immunohistochemical<br />
biomarkers related to exp<strong>and</strong>ed indicators for HER2 testing for breast cancer, as well as increased dem<strong>and</strong>s for<br />
immunohistochemistry related to consultation cases.<br />
Dr. Patrick Shannon, a neuropathologist with special expertise in perinatal pathology was welcomed to our<br />
staff. As well as his other duties, Dr. Shannon will have responsibility for the adult autopsy service, as well as<br />
administrative direction of ultrastructural pathology.<br />
Cytopathology<br />
Planning is underway to exp<strong>and</strong> the capacity of the liquid-based cytopathology technology with more automated<br />
equipment.<br />
Dr. Shabin Nanji, a cytopathologist with special interest in education <strong>and</strong> telepathology, has been recruited to<br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>. Dr. Nanji joined Mount Sinai Hospital in October <strong>2006</strong>.<br />
Ultrastructural <strong>Pathology</strong><br />
Dr. Bédard initiated the Electron Microscopy Service at Mount Sinai Hospital in 1972. Over the past 34 years<br />
under Dr. Bédard, this service has grown to be the most respected diagnostic electron microscopic service in<br />
Canada. Many leading pathologists in Canada, who are experts in Electron Microscopy, trained as residents<br />
with Dr. Bédard.<br />
Dr. Patrick Shannon has assumed a role of Principal Consultant for this service, succeeding Dr. Yvan Bédard.<br />
The Electron Microscopy Service continues to enjoy high utilization, particularly for examination of tumours,<br />
kidney biopsies, connective tissues <strong>and</strong> crystal analysis.<br />
Canadian Reference Centre for Cancer <strong>Pathology</strong> (CRCCP)<br />
Under the direction of Dr. Theo van der Kwast, the CRCCP continues its role as a tumour reference centre<br />
principally for pathologists in more remote communities in Canada. With Dr. Doug Tkachuk, Objective <strong>Pathology</strong><br />
Services, discussion has started on a proposal to digitize the CRCCP cases to make these cases more<br />
widely available throughout Canada.
<strong>Laboratory</strong> Genetics<br />
An active collaboration in Genetics has been established with the Lakeridge Health Centre. In Cytogenetics,<br />
this has resulted in rearrangement of workload between Lakeridge Health Centre <strong>and</strong> Mount Sinai Hospital to<br />
enhance services at both sites. Dr. Elena Kolomietz has been cross-appointed to Lakeridge Health Centre to be the<br />
<strong>Laboratory</strong> Director of Cytogenetics.<br />
Planning is underway to upgrade the software workstations for Cytogenetics. As well, Dr. Elena Kolomietz has<br />
started exploration on the deployment of gene-based microarrays in Cytogenetics. This technology, comparative<br />
genomic hybridization (CGH), has promise to identify genetic diseases not detectable by conventional Cytogenetics.<br />
Gene probes using fluorescence in situ (FISH techniques) are used to identify genes in both Antenatal Cytogenetics<br />
<strong>and</strong> in tumour tissues. Mount Sinai Hospital has received a grant from Roche Diagnostics to advance this<br />
technology, with the goal of making the technique more robust <strong>and</strong> less time consuming.<br />
In Molecular Genetics, an ABI-3130XL automated DNA sequencer was deployed together with DNA sequence <strong>and</strong><br />
fragment analysis software from Applied Biosystems, complemented by the Mutation Surveyor <strong>and</strong> Gene Marker<br />
software packages from SoftGenetics. This equipment has accelerated the diagnosis of genetic abnormalities,<br />
particularly in the Predictive Genetics of Cancer Program.<br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> is collaborating with the Hospital for Sick Children <strong>and</strong> with Solutions by<br />
Sequence, a company associated with Dr. Brenda Gallie, to provide retinoblastoma gene testing throughout<br />
Ontario.<br />
The implementation of <strong>Laboratory</strong> Information System Module “SoftGene” for Molecular Genetics is underway<br />
with a “go live” schedule for late 2007.<br />
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Andrology<br />
Plans are underway for exp<strong>and</strong>ing the ambulatory lab, as well as the Andrology Diagnostic <strong>Laboratory</strong>. Dr. Sergey<br />
Moskovtsev has been recruited as a staff scientist for the Andrology <strong>Laboratory</strong>. New tests for specimen function<br />
are being implemented. As well, a flow cytometer has been installed to provide tests to detect DNA fragmentation.<br />
Rachel <strong>and</strong> David Rubinoff Bone <strong>and</strong> Tissue Bank<br />
Over the past year, the Rubinoff Bone <strong>and</strong> Tissue Bank strengthened its capacity to provide more tissues under<br />
stringent accreditation st<strong>and</strong>ards. The Rubinoff Bank is working with the Trillium Gift of Life to provide bone tissue<br />
for applications throughout Ontario <strong>and</strong> beyond. These services are provided to other hospitals on a cost recovery<br />
basis.<br />
The Jeffrey Rubinoff Stem Cell Bank<br />
This is a new bank designed to retain autologous haematopoietic tissues for future placement in the original donor.<br />
Work on development of the bank is under the direction of Dr. Chen Wang. A key issue is decisions related to the<br />
disease indications for cell storage banking <strong>and</strong> the appropriate point in the disease progression to harvest the cells.<br />
To address these questions, Dr. Wang is investigating a class of lymphoproliferatiove disease, which by the available<br />
biomarkers can remain quiescent for at least a decade.
LABORATORY INFORMATICS<br />
<strong>Laboratory</strong> Information System<br />
In 1992 <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> (PLM) made the strategic decision to find a single vendor solution for<br />
its laboratory information systems for each laboratory section. Soft Computer Consultants (SCC) was chosen as a<br />
vendor <strong>and</strong> in 1994 the first module (a Blood Bank system) was installed. Between 1996 <strong>and</strong> 2000 other modules<br />
were installed for chemistry, hematology, microbiology <strong>and</strong> pathology. Between 2003 <strong>and</strong> 2004 the LIS underwent<br />
a major upgrade (going live November 29, 2004) involving all areas of the laboratory. With this upgrade a beta<br />
version of SoftGene was introduced to the LIS.<br />
LIS updates have continued through <strong>2005</strong> / <strong>2006</strong>, including a sequential upgrade of all the laboratory systems,<br />
going LIVE June 15, <strong>2006</strong>. SoftGene has been promoted from the beta product initially introduced, to a much<br />
more robust information system for h<strong>and</strong>ling cytogenetics information.<br />
The backend of the LIS was strengthened in <strong>2005</strong>/<strong>2006</strong>, with an upgrade of the LIS servers (completed April 13,<br />
<strong>2006</strong>) <strong>and</strong> the move of the LIS servers to the Markham data centre (March 13, <strong>2006</strong>). The move the Markham data<br />
centre ensures that the LIS information is stored <strong>and</strong> archived in a safe <strong>and</strong> reliable manner.<br />
Exp<strong>and</strong>ed Interfaces<br />
The main clinical laboratory underwent a major renovation in <strong>2005</strong>/<strong>2006</strong>. With this renovation a number of new<br />
analytical machines were introduced to the laboratory. The interface to the Roche analytics <strong>and</strong> per-analytics was<br />
implemented in September, <strong>2005</strong> <strong>and</strong> the interface to the Biorad Variant II was implemented in May <strong>2006</strong>.<br />
Citrix Support<br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> has worked to allow all the professional staff remote access to network drives<br />
<strong>and</strong> the <strong>Laboratory</strong> Information System via a Citrix solution. Following corrections found in the pilot project, the<br />
Citrix solution has allowed the access to crucial files <strong>and</strong> information from remote locations around the world.<br />
The introduction of the Citrix solution has also allowed several pathologists <strong>and</strong> support staff to work off-site.<br />
Web Site/Communications<br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> has worked in connection with Mount Sinai Public relations to create a distinct<br />
web site. Part of this project was the joint supervision of a communications student (Keefe Lee) for web site<br />
development. In addition, PLM is working with the Mount Sinai library to assist in the development of web site<br />
content <strong>and</strong> other departmental communications.<br />
The initial web site went live in the spring of <strong>2005</strong>. Further enhancements have been made to the site <strong>and</strong> the<br />
content has been enriched since the initial site was launched.<br />
Mr. Keefe Lee has continued to develop departmental communications media <strong>and</strong> is working on developing<br />
products for PLM research services.<br />
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Paradigm Document Control System<br />
Controlling the hundreds of documents within PLM is a monumental task. To assist with management of the<br />
laboratory documentation, the Paradigm Document Control System was introduced June 1st, <strong>2006</strong>. As part of<br />
this system all members of PLM have access to necessary documents through a web interface. Using this system<br />
it should be possible to ensure that all members of the staff are using the current <strong>and</strong> most up to date version<br />
of St<strong>and</strong>ard Operating Protocols. This program should also help assist with the continual document review <strong>and</strong><br />
updating that occurs within <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>.<br />
Digital Imaging<br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> has continued to move from traditional photography to digital imaging<br />
solutions. All gross images are taken with digital cameras <strong>and</strong> the vast majority of photomicrographs are taken<br />
digitally (all pathologists have digital cameras <strong>and</strong> a shared digital camera is available for residents).<br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> is also continuing to evaluate <strong>and</strong> consider a number of solutions to h<strong>and</strong>le the<br />
growing number of digital images. Finding the solution to h<strong>and</strong>le all of PLM’s digital needs is not a trivial matter.<br />
Investigation into possible solutions is ongoing.<br />
Digital X-Rays<br />
A system to capture digital X-Rays was introduced in <strong>2006</strong>, moving PLM to essentially complete digital imaging.<br />
As a complete digital imaging management solution for the department has not yet been implemented,<br />
an interim solution using a picture archiving <strong>and</strong> communications system (PACS) has been introduced for the<br />
digital X-Rays.<br />
Digital Slide Scanning<br />
A complete slide scanner was introduced to PLM in <strong>2006</strong>. This system incorporates technologies from a<br />
variety of companies, including software from Visiopharm that has advanced capabilities in image analysis <strong>and</strong><br />
morphometry.<br />
The digital slide scanner has also been introduced to assist with the interpretation of the tissue slide microarrays<br />
that are being produced within the department. Using the slide scanner <strong>and</strong> microarray software it<br />
should be possible to capture individual images of all the cores within the microarray. These images will then<br />
be incorporated with the data from the cores, allowing both local <strong>and</strong> distant interpretation <strong>and</strong> analysis of<br />
our microarray data.
RENOVATIONS & RELOCATIONS<br />
The exp<strong>and</strong>ed Rapid Response <strong>Laboratory</strong> was opened on December 19, <strong>2005</strong> by Mr. George Smitherman, Minister<br />
of Health of Ontario in conjunction with his announcement of the Designated Medical Equipment funding for<br />
laboratory services. The highlight of the Rapid Response <strong>Laboratory</strong> expansion is the Roche chemistry system. This<br />
fully automated system includes extensive pre-analytical automation as well as automated chemistry <strong>and</strong> immunochemistry<br />
analyzers all linked by an automated specimen conveyor system. The pre-analytical component consists<br />
of centrifuges <strong>and</strong> specimen aloquoting system. This facility is amongst the most advanced in the world. Early<br />
experience indicates that this instrumentation is fulfilling its promise of decreasing labour <strong>and</strong> decreasing turnaround<br />
time. With the relocation of the Sysmex hematology system to be immediately adjacent to the chemistry<br />
system, the Rapid Response <strong>Laboratory</strong> is even more capable of providing fast, efficient service at all times. In the<br />
next phases of this project, space will be made available for new specialized chemistry analyzers, new coagulation<br />
instruments, an automated blood bank system <strong>and</strong> new refrigerated storage.<br />
This project was accompanied by the completion of the HVAC renovation of this portion of the laboratories, <strong>and</strong><br />
the installation of a sprinkler system. These features have greatly enhanced the capacity <strong>and</strong> flexibility of the Rapid<br />
Response <strong>Laboratory</strong>.<br />
In June <strong>2006</strong> Dr. Eleftherios Diam<strong>and</strong>is relocated his research laboratories to the Koffler Centre at 60 Murray Street.<br />
These laboratories will be adjacent to the clinical facilities for the Koffler Centre for Men’s Health as well as the<br />
research genetics facilities associated with Drs. Bharati Bapat, Steve Gallinger <strong>and</strong> Hilmi Özçelik all of whom are<br />
members of <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>.<br />
Over the current year Mount Sinai Hospital embarked on a plan for capital renewal which includes both short term<br />
<strong>and</strong> long term capital planning.<br />
In the short term, <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> is planning facilities for its Andrology Ambulatory <strong>Laboratory</strong>,<br />
renovation/expansion of the 3rd floor ambulatory lab at the Ontario Power Generation building to accommodate<br />
the expansion of the Women’s Program. As well, facilities for flow cytometry, a specialized facility to enable protein<br />
extractions, a facility to house an advanced, high resolution, specialized x-ray machine, space for morphometry<br />
including tissue microarray, <strong>and</strong> expansion of laboratory genetics space are planned.<br />
In the longer term a comprehensive plan for renovation/expansion of Histology <strong>and</strong> Autopsy facilities is planned as<br />
well as more definitive <strong>and</strong> purpose built space for laboratory genetics.<br />
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QUALITY PROGRAMS<br />
Accreditations, Regulatory Certifications/Registrations<br />
The pursuit of high quality in all our activities for the benefit of our patients, students <strong>and</strong> clients is a continuous<br />
endeavour within <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>. The year was marked with significant enhancement in<br />
developing a core set of laboratory patient safety goals for pre- <strong>and</strong> post-analytic laboratory processes such<br />
as patient/sample identification, verification & communication of life threatening or life altering information,<br />
identification/communication/correction of errors <strong>and</strong> more importantly coordination of the laboratory patient<br />
safety role within the hospital.<br />
The accreditations <strong>and</strong> quality programs listed below reflect <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>’s deep<br />
commitment to quality:<br />
• <strong>Laboratory</strong> Accreditation Program (LAP), College Of American Pathologists, On-site inspection June 3, <strong>2005</strong>.<br />
Fully accredited until June 27, 2007.<br />
• Ontario <strong>Laboratory</strong> Accreditation Program (OLA) based on ISO 15189, Quality Management Program<br />
– <strong>Laboratory</strong> Services (QMP-LS), Ontario Medical Association (OMA). Successfully completed January 28, 2004.<br />
Certification valid until May 28, 2009.<br />
• <strong>Laboratory</strong> License # 4194, Ministry of Health <strong>and</strong> Long-Term Care, Ontario. Issue date April 02, <strong>2006</strong>.<br />
• Acute Care St<strong>and</strong>ard-8 (<strong>Laboratory</strong>), Canadian Councils For Health Services Accreditation (CCHSA), Hospital<br />
Acute care St<strong>and</strong>ards, January 16 -18, <strong>2006</strong>.<br />
• American Association Of Tissue Banks (AATB), Re-accredited June 9, 2004 Musculoskeletal Tissue Program<br />
with Level `A’. Expires June 15, 2007.<br />
• Food <strong>and</strong> Drug Administration, Department of Health <strong>and</strong> Human Services, U.S. Good <strong>Laboratory</strong> Practice<br />
(cGLP) st<strong>and</strong>ards for clinical <strong>and</strong> pre-clinical research laboratory services based on U.S. Federal Register, 21 CFR<br />
Part 58.<br />
• Certificate Of accreditation in Medical <strong>Laboratory</strong> Technology Training. The Michener Institute for Applied<br />
Health Sciences <strong>and</strong> Partner Sites, 2003.<br />
• Canadian College of Medical Genetics Accreditation - approval to 2008. CCMG Committee. Recognized<br />
training site for cytogenetics technologists <strong>and</strong> cytogeneticists.
External Quality Assessment Programs<br />
• Surveys & Anatomic <strong>Pathology</strong> education programs, College Of American Pathologists. 325 Waukegan Road,<br />
Northfield, IL 60093-2750. Inter-laboratory Proficiency Testing Surveys, Q-probes & Education Case Studies:<br />
Biochemistry, Hematopathology, Transfusion <strong>Medicine</strong>, Immunopathology, Flow Cytometry, Anatomic <strong>Pathology</strong><br />
-Performance Improvement Program, Cytopathology- cervicovaginal & Non-Gynae, Cytogenetics, Point-Of-Care<br />
Testing, Cytogenetics, Molecular <strong>Pathology</strong>, Andrology, Maternal Serum Screening, Instrumentation, Linearity<br />
surveys etc. Audio conferences, <strong>Laboratory</strong> Inspection Checklists<br />
• Quality Management Program – <strong>Laboratory</strong> Services (QMP-LS), OMA, Toronto<br />
M<strong>and</strong>atory External Quality Assessment Program (EQA). For complete Testing Program, visit QMP-LS website.<br />
http://www.qmpls.org<br />
• The European Molecular Genetics Quality Network (EMQN), National Genetics Reference <strong>Laboratory</strong>, c/o<br />
Regional Molecular Genetics <strong>Laboratory</strong>, St Mary’s Hospital, Hathersage Road, Manchester M13 0JH, UK.<br />
EQA registrations: Hereditary non-polyposis colon cancer, Y-Chromosome microdeletion<br />
• Fetal <strong>Medicine</strong> Foundation: The Fetal <strong>Medicine</strong> Centre, 137 Harley Street, London WIG 6BG, U.K.<br />
• Vitamin D External Quality Assessment Scheme (DEXAS), London, UK<br />
• American Society for Clinical <strong>Pathology</strong> (ASCP). Continuing Education Programs Teleconferences, <strong>2005</strong> -<strong>2006</strong>.<br />
ASCP, 2100 West Harrison Street, Chicago IL 60612.<br />
• Clinical <strong>and</strong> <strong>Laboratory</strong> St<strong>and</strong>ards Institute (formerly NCCLS)<br />
Training & Competence Assessment; GP21-A2, 2004<br />
H<strong>and</strong>ling & processing of blood specimens, H18-A3, November 2004.<br />
Clinical <strong>Laboratory</strong> Safety; GP17-A2, 2004; M29-A2; GP5-A2<br />
Dangerous Good Regulations (TDGR, IATA), TDG Clear language -2004<br />
Application of Quality Management System Model for <strong>Laboratory</strong> Services, GP26-A3, HS1-A2<br />
Molecular Methods (SC25-L), Molecular Diagnostic methods for genetic diseases–MM1A.<br />
Fluorescence In Situ Hybridization (FISH) methods for Medical Genetics proposed guideline MM7-A, 2004<br />
<strong>Laboratory</strong> Documents, GP2-A5, <strong>2006</strong>.<br />
• Continuous Quality Improvement: Essential Management Approaches, GP22-A2<br />
• Basic Safety Requirements for Human Cells, Tissues <strong>and</strong> Organs for Transplantation’ Guidance Document – July<br />
<strong>2005</strong>. Health Products <strong>and</strong> Food Branch, Health Canada.<br />
• Human Cells, Tissues, <strong>and</strong> Cellular <strong>and</strong> Tissue-based products – FDA 21 CFR Part 1271<br />
Current Good Tissue Practices (GTP) Final Rule, 2004.<br />
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• Schulich School Of Business, York University, Toronto, Ontario, Canada.<br />
Management Leadership (Executive Development) sessions for laboratory management, January,<strong>2006</strong>:<br />
`Essential Skills To Achieve A Conflict Free Work Environment’<br />
May, <strong>2005</strong>: `Strategic Mindset In-Company Workshop’<br />
April 2004: `Improving Personal & Team Leadership Dynamics’<br />
• Clinical <strong>Laboratory</strong> Management Association (CLMA): Teleconferences `Management Leadership’ series. CLMA<br />
Executive Office, 989 Old Eagle School Road, Suite 815, Wayne PA 19087.<br />
Continuous Quality Improvement Activities: Indicators<br />
In our continuing efforts to improve laboratory processes, numerous of quality indicators were monitored <strong>and</strong><br />
posted on our internal network.<br />
Quality Management Team Activities: <strong>2005</strong>-<strong>2006</strong><br />
• CAP <strong>Laboratory</strong> Accreditation inspection successfully completed on June 3rd, <strong>2005</strong> with 98.7%<br />
compliance to the industry requirements<br />
• Implementation of document management software `PARADIGM II’ (In-progress)<br />
• QMS Team completed full documentation (policy-process-procedure <strong>and</strong> mechanism to document) on two<br />
Quality System Essentials (QSEs)<br />
a. Service & Satisfaction<br />
<strong>Laboratory</strong> service satisfaction survey was carried out with overall rating of<br />
`Very Good’ laboratory services.<br />
b. Occurrence Management: a complete review <strong>and</strong> revision of incident documentation process was<br />
carried out in keeping with the hospital process <strong>and</strong> revised patient safety goals.<br />
• Self-assessment of Rubinoff Bone & Tissue Bank against new Health Canada guidelines released July-<strong>2005</strong>.<br />
• St<strong>and</strong>ard 8, the Canadian Council on Health Services Accreditation (CCHSA)<br />
Successfully completed for the hospital <strong>2006</strong> accreditation visit.<br />
• <strong>Laboratory</strong> safety committee reviewed <strong>and</strong> completed HIROC (Health Insurance Reciprocal Of Canada) survey<br />
(Modules: Orientation, POC,Privacy), MSH’s insurer.
EDUCATION<br />
Educational Activities July <strong>2005</strong> – June <strong>2006</strong><br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> continues to be actively involved with education at several levels, from continuing<br />
education for medical professionals to providing experiences for high school students. All medical, scientific<br />
<strong>and</strong> support staff are strongly encouraged to participate in education activities.<br />
Education Committee<br />
The education committee consists of Drs. Aaron Pollett, Christina MacMillan <strong>and</strong> Terry Colgan. The committee<br />
meets as required throughout the year to discuss various components of undergraduate, resident, fellow <strong>and</strong> postgraduate<br />
medical education at PLM. Dr. Christina MacMillan continued to organize educational rotations for core<br />
pathology <strong>and</strong> visiting residents <strong>and</strong> medical students. Dr. Aaron Pollett continued to organize clinical fellowships<br />
for core <strong>and</strong> visiting post-residency fellows at PLM.<br />
All three members form the core of the fellowship selection committee.<br />
Medical Education<br />
Undergraduate Medical Education<br />
Our staff continues to participate in the year II Pathobiology of Disease Course, supplying six tutors for small<br />
group instruction, as well as participating in lectures <strong>and</strong> conducting laboratory sessions. The tutors for the<br />
<strong>2005</strong> Pathobiology of Disease course were Drs. Aaron Pollett, Anita Bane, Anna Marie Mulligan, Robert Riddell,<br />
Niki MacNeill <strong>and</strong> Anne-Marie O’Shea.<br />
Dr. Azar Azad teaches in the nutrition course of the Undergraduate medical curriculum.<br />
Dr. Barry Hoffman is the course coordinator for the Pathobiology <strong>and</strong> Clinical Biochemistry course for Pharmacy<br />
(PAT331H / PHM330Y).<br />
Elective Students<br />
Medical students are encouraged to take part in all educational activities within PLM <strong>and</strong> are welcome to<br />
spend elective time in the various pathology disciplines. Our medical student electives included Nathalia Torres,<br />
Susan James <strong>and</strong> Ilse van den Bosch (Netherl<strong>and</strong>s).<br />
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Postgraduate Medical Education<br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> continues to offer a series of rounds, conferences <strong>and</strong> seminars throughout<br />
the year (a sample schedule is given in Appendix I). Resident participation in rounds <strong>and</strong> education events,<br />
including provincial, national <strong>and</strong> international meetings is strongly encouraged.<br />
All staff have been involved with the education of residents, both from pathology programs <strong>and</strong> elective residents<br />
from a variety of other disciplines. Notable examples include Dr. Terry Colgan’s <strong>and</strong> Dr. Sarah Keating’s<br />
teaching of residents within Obstetrics <strong>and</strong> Gynecology <strong>and</strong> <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>’s support in<br />
the training of Radiology residents.<br />
Dr. Bernard Fern<strong>and</strong>es <strong>and</strong> Dr. Barry Hoffman continue to act as the residency program directors for Haematological<br />
<strong>Pathology</strong> <strong>and</strong> Clinical Biochemistry, respectively.<br />
In the past year, <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> has welcomed the following residents:<br />
Anatomic, General <strong>Pathology</strong> <strong>and</strong> Clinical Biochemistry:<br />
Dr. Brendan Dickson (Anatomic <strong>Pathology</strong>, Sarcoma, Cytopathology)<br />
Dr. Elizabeth Timonera (Anatomic <strong>Pathology</strong>)<br />
Dr. Vidhya Nair (Anatomic <strong>Pathology</strong>)<br />
Dr. Kristopher Cunningham (Anatomic <strong>Pathology</strong>)<br />
Dr. Khaldoon Aljerian (Anatomic <strong>Pathology</strong>, Sarcoma)<br />
Dr. Mohammad Jaragh (Cytopathology, Head <strong>and</strong> Neck <strong>Pathology</strong>)<br />
Dr. Ahmed Arwini (Cytopathology)<br />
Dr. Mubarak Al-Shraim (Sarcoma)<br />
Dr. Lily-Naz Hazrati (Sarcoma)<br />
Dr. Daniel Winer (Sarcoma)<br />
Dr. Bojana Djordjevic (Gyne <strong>Pathology</strong>, Sarcoma)<br />
Dr. Meagan Kennedy (Breast <strong>Pathology</strong>)<br />
Dr. Ilan Weinreb (Sarcoma / Bone pathology)<br />
Dr. Ken Craddock (Anatomic <strong>Pathology</strong>)<br />
Dr. Charis Kepron (Anatomic <strong>Pathology</strong>)<br />
Dr. Jamil Asaria (Sarcoma – research)<br />
Dr. Dina El Demellawy (Anatomic <strong>Pathology</strong>, Cytopathology)<br />
Dr. Quoc Hung Huynh (General <strong>Pathology</strong>)<br />
Dr. Catherine Chung (Breast pathology)<br />
Dr. Kalawathy Sivarajah (Clinical Biochemistry)<br />
Dr. Lalitha Gunapalan (Clinical Biochemistry, Hematopathology)<br />
<strong>Pathology</strong> Residents from Other Locations<br />
Dr. Domenic Akpan, Nigeria (Surgical <strong>Pathology</strong>)<br />
Dr. Hameed Aljawad, McMaster (Sarcoma)
Residents from other programs:<br />
General Surgery<br />
Dr. Sundeep Rai<br />
Dr. Daphna Barsuk<br />
Dr. Karen Devon<br />
Dr. Pavi Kundhal<br />
Dr. Sal Privitera<br />
Medical Genetics<br />
Dr. Hanna Faghfoury<br />
Obstetrics <strong>and</strong> Gynecology<br />
Dr. Colleen McDermott<br />
Dr. Ari Baratz<br />
Dr. Nihal Al-Riyami<br />
Dr. Sabrina Lee<br />
Dr. Eve Fried<br />
Dr. Neelam Sierra<br />
Dr. Susan Kim<br />
Dr. Kerry Wilson Myckan<br />
Dr. Rachel Spitzer<br />
Radiology<br />
Dr. Ida Chan<br />
Clinical Fellows<br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> has continued to be successful in attracting international fellows. In the<br />
past year, our department has welcomed the following <strong>Laboratory</strong> Physicians:<br />
Dr. Anita Bane (Irel<strong>and</strong>), Breast <strong>Pathology</strong> (PhD c<strong>and</strong>idate)<br />
Dr. Anna Marie Mulligan (Irel<strong>and</strong>), Breast <strong>Pathology</strong><br />
Dr. Anne-Marie O’Shea (Irel<strong>and</strong>), Gastrointestinal <strong>Pathology</strong><br />
Dr. Da-Elene van der Merwe (South Africa) - Clinical Biochemistry<br />
Dr. Facundo Las Heras (Chile), Bone <strong>Pathology</strong>; PhD c<strong>and</strong>idate – Institute of Medical Sciences<br />
Dr. Michael Curtis, Cytopathology<br />
Dr. Valerie Dube, Gyne <strong>Pathology</strong><br />
Dr. Niki MacNeill, Gyne <strong>Pathology</strong><br />
Dr. Richard Kirsch (South Africa), Gastrointestinal <strong>Pathology</strong><br />
Dr. David Good, Hematopathology<br />
Dr. Abdel Alwraikat, Hematopathology<br />
Dr. Nusrat Hussein<br />
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Fellows in Clinical Biochemistry<br />
Dr. Isolde Seiden-Long<br />
Dr. Hui Li<br />
Dr. Sergei Likhodii<br />
The Alan Pollard Award for Scientific Achievements by a Post-Doctoral Diploma Program<br />
Trainee<br />
To honour Dr. Alan Pollard’s distinguished contribution as head of Clinical Biochemistry at Mount Sinai<br />
Hospital for over 28 years, the Alan Pollard Award was established. This award recognizes the Clinical<br />
Biochemistry trainee who has submitted for presentation the most distinguished paper. The award<br />
consists of travel expenses to a major meeting to present the research findings. The awardee for <strong>2005</strong> is<br />
Dr. Paul Yip.<br />
Fellows from other programs:<br />
Dr. Rebecca Gladdy (Surgical Oncology)<br />
PLM teamed with the University Health Network <strong>and</strong> the Hospital for Sick Children to create a tri-hospital<br />
Gastrointestinal pathology fellowship program. The supervisors at PLM are Drs. Robert Riddell <strong>and</strong><br />
Aaron Pollett. This program continued into <strong>2005</strong> – <strong>2006</strong> with Dr. Richard Kirsch receiving the fellowship<br />
position.<br />
Dr. Sarah Keating continued her dedicated Perinatal <strong>Pathology</strong> rotation for clinical fellows in Maternal-<br />
Fetal <strong>Medicine</strong> through the past year. Dr. Karen Bishop spent extended time in perinatal pathology.<br />
Cytogenetic Fellows<br />
PLM welcomed a cytogenetics fellow, Dr. Anne George.
Continuing Medical Education<br />
Dr. Terence Colgan continued as Co-Director of the University of Toronto <strong>Annual</strong> <strong>Pathology</strong> Update Course<br />
though November <strong>2005</strong>. This pathology update course is one of the largest pathology CME events hosted by<br />
the University of Toronto.<br />
Dr. Iona Leong continued to coordinate the Head <strong>and</strong> Neck Group <strong>Pathology</strong> Rounds she initiated in 2002.<br />
These rounds are a monthly educational event for regional anatomic <strong>and</strong> oral pathologists focused around<br />
interesting head <strong>and</strong> neck pathology. These rounds are hosted by <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>.<br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> staff continues in a variety of specialty clinical rounds on a regular basis,<br />
including several rounds that are driven by members of our department. These rounds include:<br />
Breast Tumour Board: Dr. Frances O’Malley<br />
General Surgery/Gastrointestinal Rounds: Dr. Robert Riddell<br />
Inflammatory Bowel Disease Rounds: Dr. Robert Riddell<br />
Sarcoma Tumour Boards: Dr. Rita K<strong>and</strong>el<br />
Dr. Dave Howarth<br />
Dr. Kenneth Pritzker<br />
Head <strong>and</strong> Neck Rounds: Dr. Christina MacMillan<br />
Neonatal Rounds: Dr. Sarah Keating<br />
Dr. Patrick Shannon<br />
Gynaecologic <strong>Pathology</strong>: Dr. Terence Colgan<br />
Gastrointestinal Tumour Board: Dr. Aaron Pollett<br />
Urology Tumour Board: Dr. Theo van der Kwast<br />
Andrology Rounds: Dr. Brendan Mullen<br />
Harold G. Pritzker Memorial Lecture <strong>2006</strong><br />
Harold Goldsmith Pritzker was the Pathologist-in-Chief at Mount Sinai Hospital from 1938 to 1963. Upon his<br />
death, his colleagues in all disciplines established an <strong>Annual</strong> Memorial Lectureship Fund, which was transferred<br />
to the Academy of <strong>Medicine</strong>. A committee was created, which included representatives of the founding<br />
bodies, namely the Academy of <strong>Medicine</strong>, Mount Sinai Hospital <strong>and</strong> the University of Toronto. With the<br />
demise of the Academy of <strong>Medicine</strong> in 1992, the <strong>Annual</strong> Memorial Lecture continued with the generous support<br />
of the hospital administration <strong>and</strong> the Department of <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> of Mount Sinai<br />
Hospital. The initial lecture was delivered in 1965. Throughout the years, this lecture has become one of<br />
the most distinguished lecture series attracting some of the most celebrated names in <strong>Pathology</strong> <strong>and</strong> related<br />
fields.<br />
The guest lecturer for the 41st <strong>Annual</strong> Pritzker Memorial Lecture was Professor Olli Kallioniemi from Finl<strong>and</strong>,<br />
who presented “Translational Cancer Systems Biology” April 24th, <strong>2006</strong>.<br />
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Research Student Programs<br />
Undergraduate Research<br />
<strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong> continued to provide summer research experience for undergraduate<br />
students. A total of 19 summer students were at PLM over the summer of <strong>2006</strong> under the supervision of 15<br />
different staff members. The list of summer students with their supervisors <strong>and</strong> titles/projects is presented in<br />
Appendix H.<br />
Faculty of Applied Science <strong>and</strong> Engineering Undergraduate Project Students, Nanotechnology<br />
In <strong>2005</strong>-<strong>2006</strong>, Dr. Kenneth Pritzker supervised two students:<br />
Ms. Grace So, Materials Science <strong>and</strong> Engineering:<br />
Thesis title “Characterization of Hydrophobic Fullerene Derivatives <strong>and</strong> Liposome Formulations for Potential<br />
Applications in Photodynamic Therapy”<br />
Mr. Lawrence Lee, Engineering Science:<br />
Thesis title “Characterization <strong>and</strong> Gold-Doping of Hexadecaanilinated Carbon Nanotubes”.<br />
Faculty of Arts <strong>and</strong> Sciences, <strong>Laboratory</strong> <strong>Medicine</strong> <strong>and</strong> Pathobiology,<br />
Undergraduate Project Students<br />
In <strong>2005</strong>-<strong>2006</strong>, Dr. Kenneth Pritzker supervised Mr. Jovil Kanampuza in his studies on effects of alkaline phosphatase<br />
of calcium pyrophosphate dihydrate crystal dissolution.<br />
Dr. Rita K<strong>and</strong>el supervised Mr. Edward Hadzocos, project title: p53 <strong>and</strong> benign breast disease”; <strong>and</strong> Mr. Igal<br />
Raizman, project title: “Mechanical stimulation <strong>and</strong> its effect on the different zones of cartilage.<br />
Graduate Students<br />
Forty-six graduate students are under the supervision of 8 PLM staff. A list of graduate students with their<br />
project titles <strong>and</strong> supervisors is presented in Appendix D.<br />
We are proud to have several award winners among our graduate students, including:<br />
Facundo Las Heras (Kenneth Pritzker), ACE Trainee studentship award<br />
Miralem Mrkonjic (Bharati Bapat), MSc LMP Award (Graduate student research day)<br />
In addition to direct supervision of graduate studies, the staff also coordinate numerous graduate courses offered<br />
by the University of Toronto, including:<br />
LMP1016 <strong>Pathology</strong> of Connective Tissue (Dr. K.P.H. Pritzker)<br />
LMP 1407 Introductory Biostatistics <strong>and</strong> Clinical Investigation (Dr. R. Veith)<br />
LMP 1506 Techniques in Functional Genomics <strong>and</strong> Proteomics (Dr. E. Diam<strong>and</strong>is)
Postgraduate Students<br />
Twenty-one postdoctoral students are currently pursuing research studies in <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>.<br />
A list of postdoctoral students with their project titles <strong>and</strong> supervisors is listed in Appendix G.<br />
Technical Education<br />
Medical <strong>Laboratory</strong> Science Program<br />
This program includes training in microbiology, blood transfusion services, haematopathology, biochemistry<br />
<strong>and</strong> histotechnology. A total of eight students from three different programs undergo portions of clinical<br />
training at PLM.<br />
St. Lawrence College<br />
Emily Dabous, Connie Pearson, Gefei Wang<br />
The Michener Institute<br />
Bjorn Greppmayr, Wei Liu, Lisa Manning <strong>and</strong> Catherine P<strong>and</strong>y<br />
Mohawk College<br />
Mohammed Ghannam (short program for foreign graduates)<br />
Discussions are underway with the Medical <strong>Laboratory</strong> Science Program of the Ontario Institute of Technology<br />
to provide clinical experience for their students.<br />
Mount Sinai Hospital is also engaged in teaching cytopathology students from the Michener Institute related<br />
to changes in curriculum. No students were present at MSH over the past year.<br />
Genetics Technology<br />
Three students in the Genetic Technology Programme underwent their clinical rotations at Mount Sinai Hospital.<br />
The students were:<br />
Ana Baptistia<br />
Kayu Chin<br />
Nadine Sharpe<br />
Mark Ballantyne<br />
Am<strong>and</strong>a Fowler.<br />
Starting in 2004, John Tzountzouris has been appointed the clinical coordinator for the Molecular Genetics<br />
Rotations <strong>and</strong> he continued in this role through <strong>2005</strong>.<br />
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Continuing Education: Technical <strong>and</strong> Support Staff<br />
Technical <strong>and</strong> support staff are strongly encouraged to attend courses, seminars, lectures <strong>and</strong> conferences <strong>and</strong><br />
congresses. In <strong>2005</strong> / <strong>2006</strong> 60 staff members were sponsored for over 90 courses <strong>and</strong> seminars.<br />
Continuing education via teleconference is offered to all staff (the list of teleconferences offered in <strong>2005</strong> /<br />
<strong>2006</strong> is given in Appendix J).<br />
Monthly In-Service Education sessions for the histotechnology <strong>and</strong> cytotechnology staff continue to be well<br />
attended. These sessions are coordinated by Jan Church <strong>and</strong> have included presentations delivered by the<br />
departmental technical <strong>and</strong> professional staff.<br />
Monthly Genetics Educations Sessions, presented by scientific experts in the field are provided for all PLM<br />
technical genetics staff. These rounds were initiated by John Tzountzouris in 2003 <strong>and</strong> continued through the<br />
<strong>2005</strong> / <strong>2006</strong> academic year.<br />
Schulich School of Business Education Opportunities<br />
These Schulich courses are organized under the leadership of Mr. Vince D’Mello <strong>and</strong> are designed to<br />
enhance the management skills of our staff. One course was offered to members of the PLM in <strong>2005</strong><br />
– <strong>2006</strong>:<br />
“Working Towards a Conflict Free Work Environment”, January 12th <strong>and</strong> 13th, <strong>2006</strong>, attended by 23<br />
staff members.<br />
Volunteer Student Program<br />
Several high school students spent up to five months at <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>, predominately<br />
in the Cytopathology <strong>and</strong> Surgical <strong>Pathology</strong> sections. This very successful co-operative programme exposes<br />
these students to observe, at an early stage, the important role played by laboratory medicine in the diagnosis<br />
<strong>and</strong> management of patients. After completion of the programme, the students usually receive a high school<br />
credit or an Ontario Academic Credit (OAC).<br />
With the Volunteer’s Office, volunteers are encouraged to observe <strong>and</strong> assist in the laboratories. Occasionally,<br />
these volunteers are high school students but, more frequently, are university undergraduates seeking additional<br />
exposure to a medical environment.
SPONSORED RESEARCH AND INNOVATION<br />
Research <strong>and</strong> Innovation continues principally in cancer diagnostics, articular skeletal diseases <strong>and</strong> bioengineering,<br />
fetal <strong>and</strong> perinatal diseases <strong>and</strong> genetics. Much of this work is collaborative, internally with clinical colleagues<br />
<strong>and</strong> with investigators at the Samuel Lunenfeld Research Institute <strong>and</strong> externally with colleagues in similar<br />
fields worldwide. The activities, although in a few select areas, do range from fundamental research through<br />
translational research, introduction of innovation <strong>and</strong> reduction to practice. This is reflected in the broad range of<br />
public <strong>and</strong> corporate sponsors of the Research <strong>and</strong> Innovation activity within <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>.<br />
Investigator Granting Agency Title Amount<br />
Dr. I. Andrulis<br />
Dr. R. Bell (PI)<br />
et al<br />
Dr. I. Andrulis<br />
Co-PI with<br />
Dr. J. Wunder<br />
Dr. I. Andrulis<br />
Co-PI with<br />
Drs. S. Bull &<br />
Dr. F. O’Malley<br />
Dr. I. Andrulis<br />
Dr. A.M. Chiarelli (PI)<br />
P. Ritvo, N. Klar,<br />
J, Knight, F. O’Malley<br />
Dr. I. Andrulis<br />
Dr. J.M. Rommens (PI)<br />
N.F. Boyd, A.D.<br />
Paterson,<br />
M.J. Yaffe, I. Andrulis<br />
Dr. Chenevix-trench (PI)<br />
Dr. I. Andrulis<br />
Dr. B. Bapat (PI)<br />
Dr. L. Briollais<br />
Canadian Institutes of Health<br />
Research<br />
Interdisciplinary health research team in<br />
musculoskeletal neoplasia<br />
Ontario Cancer Research Network Identification of novel prognostic markers <strong>and</strong><br />
Canadian Breast Cancer<br />
Foundation<br />
Canadian Breast Cancer Research<br />
Alliance<br />
Canadian Breast Cancer Research<br />
Alliance<br />
therapeutic targets in osteosarcoma<br />
Use of CGH arrays to identify genes involved in<br />
breast cancer<br />
Screening behaviors <strong>and</strong> outcomes among relatives<br />
of women with breast cancer<br />
Association of lipid gene haplotypes with breast<br />
density <strong>and</strong> cancer<br />
$252,430<br />
$133,561<br />
$92,326<br />
$196,966<br />
$312,413<br />
National Institutes of Health The role of the ATM gene in familial breast cancer $23,000<br />
Canadian Institutes of Health<br />
Research<br />
Role of Rac1 GTPase in regulation of Wnt pathway<br />
in colon cancer<br />
$106,014<br />
Dr. B. Bapat (PI) Ontario Cancer Genetic Network Predisposition to Colon Cancer Program $12,715<br />
Dr. B. Bapat (PI)<br />
Dr. N. Fleshner<br />
Dr. J. McLaughlin (PI)<br />
Dr. B. Bapat et al<br />
Dr. T. Colgan<br />
Dr. M. Siu (PI)<br />
Dr. A. Romaschin<br />
Canadian Prostate Cancer<br />
Research Initiative-Idea Grant<br />
Canadian Institutes of Health<br />
Research<br />
National Cancer Institute of<br />
Canada<br />
MYH mutations <strong>and</strong> prostate cancer risk $50,000<br />
A program of interdisciplinary <strong>and</strong> population based<br />
studies of the determinants <strong>and</strong> impact of colorectal<br />
cancer. A genetic epidemiological approach.<br />
Biomarker discovery, identification <strong>and</strong> verification<br />
using tissue proteomics in an endometrial cancer<br />
model<br />
$115,572<br />
$149,210<br />
|<br />
27
Investigator Granting Agency Title Amount<br />
Dr. T. Colgan<br />
Dr. M. Siu (PI)<br />
Dr. A. Romaschin<br />
Dr. G. Denomme (PI)<br />
Drs. J. Callum,<br />
J. Pendergrast<br />
Dr. G. Denomme<br />
Dr. W. Lau (PI)<br />
Dr. G. Denomme<br />
Dr. N. Shehata (PI)<br />
Drs. J. Freedman,<br />
Dr. G. Denomme<br />
Dr.J. Freedman (PI)<br />
Drs. N.S. Shehata<br />
Dr. G. Denomme<br />
Dr. J. Hannon (PI)<br />
Drs. G. Clarke,<br />
J. Ashdown, G. Barr<br />
Dr. G. Denomme (PI)<br />
Dr. W. Sheffield<br />
Canadian Institutes of Health<br />
(CIHR) Proof of Principle<br />
Canadian Blood Services Kenneth<br />
J. Fyke Award-2004 Competition<br />
Small Project Fund Canadian<br />
Blood Services<br />
Small Project Fund Canadian<br />
Blood Services<br />
Small Project Fund Canadian<br />
Blood Services<br />
Small Project Fund Canadian<br />
Blood Services<br />
Intramural Grant Canadian Blood<br />
Services<br />
Dr. E. Diam<strong>and</strong>is (PI) NSERC/University of Toronto(with<br />
Dr. E. Diam<strong>and</strong>is<br />
Dr. R. K. Nam (PI)<br />
Dr. E. Diam<strong>and</strong>is<br />
Dr. I. Scarisbrick (PI)<br />
Oncotherapeutics)<br />
National Cancer Institute of<br />
Canada<br />
Diagnosis of endometrial cancer $149,570<br />
Blood group DNA genotyping: Meeting the dem<strong>and</strong><br />
for antigen- specific blood<br />
$50,000<br />
Analysis of ABO discrepancies $6,400<br />
HPA genotyping platelet apheresis donors $14,190<br />
HPA alloantibodies in platelet apheresis donors $14,940<br />
RHD alleles in prenatal patients $12,917<br />
Soluble recombinant Dombrock <strong>and</strong> Lutheran<br />
blood group antigens: Towards improved care for<br />
alloimmunized transfusion recipients<br />
$66,000<br />
Kallikreins as disease biomarkers $150,000<br />
Prospective evaluation of prostate biopsies for<br />
prostate cancer detection<br />
National Multiple Sclerosis Society Range of action of the kallikrein gene family in MS<br />
Dr. E. Diam<strong>and</strong>is NSERC/University (with IBEX<br />
Technologies Inc)<br />
Dr. E. Diam<strong>and</strong>is National Cancer Institutes of<br />
Dr. Julinor Bacani (PI)<br />
Dr. S. Gallinger<br />
Dr. S. Gallinger<br />
Dr. G. Petersen (PI)<br />
Canada<br />
Terry Fox Foundation Post MD<br />
Fellowship<br />
National Institutes of Health<br />
(USA)<br />
pathogenesis<br />
Biological functions of human kallikrein 14 - A novel<br />
serine protease<br />
Diagnostic utility of the normal epithelial specific 1<br />
gene (NES1) in ovarian cancer<br />
Frequency of E-cadherin (cdh1) <strong>and</strong> mismatch repair<br />
(MMR) germline mutations in young gastric cancers<br />
in Southern Ontario<br />
($210,000)<br />
$133,000<br />
$189,150<br />
$120,000<br />
$58,500<br />
$48,038<br />
Pancreatic cancer linkage consortium $120,000<br />
Dr. S. Gallinger (PI) Ontario Cancer Research Network Improving care <strong>and</strong> research in pancreas cancer in<br />
Dr. S. Gallinger<br />
Dr. B. Zanke (Co-PI)<br />
Dr. T. Hudson (Co-PI)<br />
Dr. S. Gallinger (PI)<br />
et al<br />
Ontario - A population-based study<br />
Genome Canada The ARCTIC (Assessment of risk for colorectal<br />
National Cancer Institute of<br />
Canada<br />
Dr. M. Grynpas (PI) National Science & Engineering<br />
Research Council of Canada<br />
tumors in Canada) Genome Project<br />
$123,333<br />
$50,000<br />
The MYH gene <strong>and</strong> colorectal cancer risk $141,000<br />
Mechanisms of degradation of calcium<br />
polyphosphates<br />
$30,800
Investigator Granting Agency Title Amount<br />
Dr. W.I. Stanford (PI)<br />
Dr. M. Grynpas<br />
Dr. J. Aubin<br />
Dr. A. Jurisicova (PI)<br />
Dr. M. Grynpas<br />
Dr. M. Grynpas (PI)<br />
Dr. S. Quaggin et al<br />
Dr. M. Grynpas<br />
Dr. A.M.W. Cheung (PI)<br />
Dr. M. Grynpas<br />
Dr. J.E. Aubin (PI)<br />
Dr. W.G. Cole et al<br />
Dr. M. Grynpas (PI)<br />
Dr. R. Vieth<br />
Dr. R. K<strong>and</strong>el<br />
Dr. R. K<strong>and</strong>el (PI)<br />
Dr. M. Grynpas et al<br />
Dr. R. K<strong>and</strong>el<br />
Dr. R. Bell (PI)<br />
Dr. I. Andrulis et al<br />
Dr. R. K<strong>and</strong>el<br />
Dr. T. Rohan (PI)<br />
et al<br />
Dr. R. K<strong>and</strong>el (PI)<br />
Dr. K. Siminovitch<br />
Dr. R. K<strong>and</strong>el (PI)<br />
Drs. M. Grynpas, M.<br />
Hurtig,<br />
R.M. Pilliar, J.P.<br />
Santerre,<br />
S.D. Waldman<br />
Dr. R. K<strong>and</strong>el (PI)<br />
Drs. M. Grynpas,<br />
R. K<strong>and</strong>el, G. Pilliar<br />
G. Vunjak-Novkovic<br />
Dr. R. K<strong>and</strong>el<br />
Dr. R. Pilliar (PI)<br />
Drs M. Grynpas,<br />
R. K<strong>and</strong>el, P. Zalzal,<br />
J. Medley, M. Hurtig<br />
Dr. F. O’Malley<br />
Dr. I. Andrulis (PI)<br />
Dr. Norman Boyd<br />
et al<br />
Canadian Institutes of Health<br />
Research<br />
Canadian Institutes of Health<br />
Research<br />
Canadian Institutes of Health<br />
Research<br />
Canadian Institutes of Health<br />
Research<br />
Canadian Institutes of Health<br />
Research<br />
Canadian Institutes of Health<br />
Research<br />
Canadian Institutes of Health<br />
Research<br />
Canadian Institutes of Research in<br />
Musculo- skeletal Health Research<br />
The role of stem cell antigen-1 (Sca-1) in bone<br />
development <strong>and</strong> homeostasis<br />
Importance of harikiri in regulation of oocyte <strong>and</strong><br />
embryo survival<br />
Maintenance <strong>and</strong> support for the Advanced<br />
Bioimaging Centre<br />
The clinical utility of the mechanical response.<br />
Tissue analyzer device for determining bone fragility<br />
Identification of genes responsible for human bone<br />
disease through mouse mutagenesis<br />
Can Vitamin D delay or arrest the progression of<br />
osteoarthritis<br />
$123,987<br />
$90,326<br />
$100,000<br />
$78,500<br />
$232,542<br />
$63,136<br />
Development of biological implants for joint repair $237,008<br />
Independent health research team in<br />
musculoskeletal neoplasia<br />
National Institutes of Health p53 in BBD <strong>and</strong> breast cancer risk: A multicenter<br />
cohort<br />
The Arthritis Society Factors regulating formation of bioengineering<br />
National Science & Engineering<br />
Research Council/ Canadian<br />
Institutes of Health Research<br />
articular cartilage<br />
$50,000<br />
$139,447<br />
$64,514<br />
Bioengineering a modular intervertebral disc $136,627<br />
National Institutes of Health Bioengineering annulus fibrosus using silk scaffold $135,000<br />
Canadian Arthritis Network Development of tissue-engineered joint surface<br />
replacements<br />
National Institutes of Health Ontario Family Registry for studies of breast cancer<br />
risk<br />
$23,500<br />
$182,786<br />
|<br />
29
Investigator Granting Agency Title Amount<br />
Dr. F. O’Malley<br />
Dr. I. Andrulis (PI)<br />
Dr. S. Bull<br />
Dr. F. O’Malley<br />
Dr. A. Chiarelli (PI)<br />
et al<br />
Dr. F. O’Malley<br />
Dr. I. Andrulis (PI)<br />
et al<br />
National Cancer Institute of<br />
Canada - Terry Fox Program<br />
Project<br />
Canadian Breast Cancer<br />
Foundation<br />
Canadian Breast Cancer<br />
Foundation<br />
Dr. F. O’Malley (PI) Canadian Breast Cancer<br />
Dr. F. O’Malley<br />
Dr. P. Goodwin (PI)<br />
Dr. I. Andrulis, et al<br />
Dr. H. Ozcelik<br />
Drs. Katherine Vallis/<br />
Anne Kosch (PI)<br />
Foundation<br />
Dr. H. Ozcelik (PI) Prostate Cancer Research<br />
Identification <strong>and</strong> clinical importance of novel<br />
genes/pathways involved in ANN breast cancer<br />
Evaluation of the effectiveness of nurse examiners in<br />
an organized screening program<br />
Use of CGH arrays to identify genes involved in<br />
hereditary breast cancer<br />
BRCA2 associated breast cancer: Histopathologic<br />
phenotype & molecular profile<br />
$191,334<br />
$47,416<br />
$99,951<br />
$99,238<br />
National Institutes of Health Prognosis in BRCA1 associated breast cancer $45,177<br />
Canadian Institutes of Health Genetic polymorphisms <strong>and</strong> radiation sensitivity in<br />
Foundation of Canada<br />
Dr. H. Ozcelik (PI) Canadian Breast Cancer<br />
Foundation<br />
Dr. K. Pritzker (PI) Ontario Cancer Genetics<br />
Dr. K. Pritzker<br />
Dr. J. Wrana (PI)<br />
et al<br />
Dr. K. Pritzker<br />
Dr. J.L. Henri (PI)<br />
Dr. K. Pritzker<br />
Dr. F. Las Heras<br />
Network-Research<br />
Canadian Institutes of Health<br />
Research<br />
Canadian Institutes of<br />
Health Research Institute of<br />
Musculoskeletal Health & Arthritis<br />
ACE Trainee Committee<br />
University Health Network/<br />
Toronto Western Hospital<br />
breast cancer patients<br />
DNA repair SNP profiles <strong>and</strong> response to prostate<br />
cancer radiotherapy<br />
Cross-talk between DNA repair SNPs <strong>and</strong> additive<br />
breast cancer risk<br />
$40,210<br />
$60,000<br />
$96,939<br />
Genetic DNA Registry $344,693<br />
Maintenance of core robotics facility $90,497<br />
Molecular mechanisms of pain <strong>and</strong> fatigue in<br />
osteoarthritis: interplay between nerve <strong>and</strong> joint<br />
$300,000<br />
Studenship Award $7,500<br />
Dr. R. Riddell Merck Frosst Effect of 156 weeks of treatment with MK-0966<br />
Dr. T. van der Kwast (PI) European R<strong>and</strong>omized Study of<br />
Dr. T. van der Kwast (PI)<br />
Dr. E.C. Zwarthoff<br />
Dr. R. Vieth<br />
Dr. A.M. Cheung (PI)<br />
et al<br />
Screening for Prostate Cancer<br />
Zorg Onderzoek Nederl<strong>and</strong><br />
Medische Wetenschappen<br />
Canadian Institutes of Health<br />
Research<br />
on the recurrence of neoplastic polyps of the<br />
large bowel in patients with a history of colorectal<br />
adenomas<br />
$101,922<br />
Prostate cancer screening related research $50,000<br />
Cost-effectiveness fo the follow-up of patients with<br />
superficial bladder cancer<br />
Evaluation of the use of vitamin K in<br />
postmenopausal women with osteopenia-ECKO trial<br />
$240,000<br />
$152,563
Investigator Granting Agency Title Amount<br />
Dr. R. Vieth<br />
Dr. J. Knight (PI)<br />
Dr. R. Vieth<br />
Dr. David Cole (PI)<br />
Dr. R. Vieth (PI)<br />
Dr. D. Rousseau<br />
Dr. C. Wang<br />
Dr. W. Stanford (PI)<br />
Canadian Breast Cancer<br />
Research Initiative<br />
A study of normal light exposure <strong>and</strong> melatonin in<br />
healthy women<br />
Dairy Farmers of Canada Genetics influences on the variability of responses to<br />
vitamin D supplementation<br />
Dairy Farmers of Canada Bioavailability of Vitamin D from fortified cheese, ice<br />
Canadian Institutes of Health<br />
Research<br />
cream <strong>and</strong> yogourt<br />
Phenotype-driven generation <strong>and</strong> analysis of mouse<br />
models of hematological diseases<br />
Dr. C. Wang (PI) Jeffery Rubinoff Foundation Flowcytometry cells sorter facility <strong>and</strong> hematopoietic<br />
Dr. C. Wang<br />
Dr. Warren Chan (PI)<br />
Dr. E. Winsor (PI)<br />
Dr. D. Chitayat<br />
Dr. K. Pritzker<br />
Canadian Institutes of Health<br />
Research<br />
Canadian Foundation for<br />
Innovation<br />
stem cell banking<br />
$325,665<br />
$55,000<br />
$38,000<br />
$41,200<br />
$250,000<br />
Quantum dot-based biomolecular imaging $300,000<br />
Canadian Molecular Genetic Platform $60,000<br />
16 investigators TOTAL - <strong>2005</strong>-<strong>2006</strong> $7,826,723<br />
TOTAL GRANTS <strong>2005</strong>-<strong>2006</strong> $31,770,404<br />
|<br />
31
PRESENTATIONS & ABSTRACTS<br />
July 1, <strong>2005</strong> – June 30, <strong>2006</strong><br />
Dr. Irene Andrulis<br />
Trudeau, M.E., Pritchard, K.I., Chapman, J-A, Hanna, W.M., Kahn ,H.J., Murray, D., Sawka, C.A., Mobbs, B.G.,<br />
Andrulis, I.L., McCready, D.R., <strong>and</strong> Lickley, H.L. (<strong>2005</strong>) Prognostic Factors Affecting the Natural History of Node-<br />
Negative Breast Cancer. Breast Cancer Research Treatment 89: 35-45.<br />
Bane, A.L., Tjan, S., Parkes, R., Andrulis, I.L., <strong>and</strong> O’Malley. F.P. (<strong>2005</strong>) Invasive Lobular Carcinoma: to grade or not<br />
to grade. Mod Path 18: 621-628.<br />
Wunder, J.S., Gokgoz, N., Parkes, R., Bull, S.B., Esk<strong>and</strong>arian, S., Davis, A.M., Beauchamp, C.P., Conrad, E.U.,<br />
Grimer, R.J., Healey, J.H., Malkin, D., Mangham, D.C., Rock, M.J., Bel, R.S., <strong>and</strong> Andrulis, I.L. (<strong>2005</strong>) TP53<br />
Mutations <strong>and</strong> Outcome in Osteosarcoma: A Prospective, Multicenter Study. J Clin. Oncol. 23:1483-1490.<br />
Eppert, K., K<strong>and</strong>el, R., Aneliunas, V., Wunder, J.S., <strong>and</strong> Andrulis, I.L. (<strong>2005</strong>) Von Willebr<strong>and</strong> Factor Expression in<br />
Osteosarcoma Metastasis. Mod Path 18: 388-397.<br />
Milne, R.L., Knight, J.A., John, E.M., Dite, G.S., Balbuena, R., Ziogas, A., Andrulis, I.L., West, D.W., Southey M.C.,<br />
Giles, G.G., McCredie, M.R.E., Hopper, H.L., Whittemore, A.S., for the Breast Cancer Family Registry. (<strong>2005</strong>) Oral<br />
contraceptive use <strong>and</strong> risk of early-onset breast cancer in carriers <strong>and</strong> non-carriers of BRCA1 <strong>and</strong> BRCA2 mutations.<br />
Cancer Epidemiol Biomarkers Prev 14:350-356.<br />
Eppert, K., Wunder, J.S., Aneliunas, V., Tsui, L-C., Scherer, S.W., <strong>and</strong> Andrulis, I.L. (<strong>2005</strong>) Altered expression <strong>and</strong><br />
deletion of RMO1 in osteosarcoma. Int J Cancer 114: 738-746.<br />
To, M.D., Faseruk, S.A., Gokgoz, N., Pinnaduwage, D. Done, S.J., <strong>and</strong> Andrulis, I.L. (<strong>2005</strong>) LAF-4 is Aberrantly<br />
Expressed in Human Breast Cancer. Int J Cancer 115: 568-574.<br />
Mastracci, T.L., Tjan, S., O’Malley, F.P., <strong>and</strong> Andrulis, I.L. (<strong>2005</strong>) E-cadherin alterations in atypical lobular hyperplasia<br />
<strong>and</strong> lobular carcinoma in situ Mod Path 18:741-51.<br />
Sauer, M. <strong>and</strong> Andrulis, I.L. (<strong>2005</strong>) Identification <strong>and</strong> characterization of missense alterations in the BRCA1associated<br />
RING domain (BARD1) gene in breast <strong>and</strong> ovarian cancers. J of Med Genet. 42: 633-638.<br />
He, W., Bull, S.B., Gokgoz, N., Andrulis, I.L, <strong>and</strong> Wunder, J. (<strong>2006</strong>) Application of reliability coefficients in cDNA<br />
microarray data analysis. Statist. Med. 25:1051-1066.<br />
Knight, J.A., John, E.M., Milne, R.L., Dite, G.S., Balbuena, R., Shi, E.J.Q., Giles, G.G., Ziogas, A., Andrulis, I.L.,<br />
Whittemore, A.S., Hopper, J.L. for the Breast Cancer Family Registry. (<strong>2006</strong>) An inverse association between ovarian<br />
cysts <strong>and</strong> breast cancer. Int J Cancer 118: 197-202.
Tiet, T.D., Hopyan, S., Nadesan, P., Gokgoz, N., Poon, R., Andrulis, I.L., Alman, B.A., <strong>and</strong> Wunder, J.S. (<strong>2006</strong>)<br />
Constitutive hedgehog signalling in chondrosarcoma upregulates tumor cell proliferation. Amer. J. Pathol. 168:321-<br />
330.<br />
Spurdle, A.B., Antoniou, A.C., Kelemen, L., Holl<strong>and</strong> H., Peock, S., Cook, M.R., Smith, P.L. Greene, M.H., Simard, J.,<br />
Plourde, M., Southey, M., Godwin, A., Beck, J., Miron, A., Daly, M., Santella, R., Hopper, J., John, E.M., Andrulis,<br />
I.L., Durocher, F., Struewing, J.P., ABCFS, AJBCS, BCFR, INHERIT, kConFaB, EMBRACE Study Collaborators, Easton,<br />
D.F., <strong>and</strong> Chenevix-Trench, G. (<strong>2006</strong>) The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1<br />
<strong>and</strong> BRCA2 mutation carriers. Cancer Epidemiol, Biomarkers <strong>and</strong> Prev.15:76-79.<br />
Bernstein, J.L., Teraoka, S.N., John, E.M., Andrulis, I.L., Knight, J., Lapinski, R., Olson, E.R., Wolitzer, A.L., Seminara.<br />
D., Whittemore, A.S., <strong>and</strong> Concannon, P. (<strong>2006</strong>) The CHEK2*1100delC germline mutation <strong>and</strong> risk of breast cancer.<br />
Cancer Epidemiol, Biomarkers <strong>and</strong> Prev. 15:348-352.<br />
To, M.D., Gokgoz, N., Doyle, T.G., Donoviel, D., Knight, J.A., St. George Hyslop, P., Bernstein, A. <strong>and</strong> Andrulis, I.L.<br />
(<strong>2006</strong>) Functional Characterization of Novel Presenilin-2 Variants Identified in Human Breast Cancers. Oncogene<br />
25:3557-3564.<br />
Smith, P., McGuffog, L., Easton, D.F., Mann, G.J., Pupo, G.M., Newman, B., Chenevix-Trench, G., kConFab<br />
Szabo, C., Southey, M., Renard, H., Odefrey, F., Lynch, H., Stoppa-Lyonnet, D., Couch, F., Hopper, J.L., Buys, S.,<br />
Andrulis, I.L., Senie, R., Breast Cancer Family Registry, BRCAX Collaborators group, Goldgar, D.E., Oldenburg, R.,<br />
Kroeze-Jansema, K., Kraan, J., Meijers-Heijboer, H., Klijn, J.G.M., van Asperen, C., van Leeuwen, I., Vasen, H.F.A.,<br />
Cornelisse, C.J., Devilee, P., Baskcomb, L., Seal, S., Barfoot, R., Mangion, J., Hall, A., Edkins, S., Rapley, E., Wooster,<br />
R., Chang-Claude, J., Eccles, D., Evans, D.G., Futreal, P.A., Nathanson, K.L., Weber, B.L., Breast Cancer Susceptibility<br />
Collaboration (UK), Rahman, N., Stratton, M.R. (<strong>2006</strong>) A genome wide linkage search for breast cancer susceptibility<br />
genes. Genes, Chromosomes <strong>and</strong> Cancer 45: 646-655.<br />
Pritchard K.I., Shepherd L.E., O’Malley F.P., Andrulis I.L., Tu D., <strong>and</strong> Levine M.N. for the National Cancer Institute<br />
of Canada Clinical Trials Group. (<strong>2006</strong>) Neu/ErbB2 <strong>and</strong> responsiveness of breast cancer to adjuvant chemotherapy.<br />
New Engl<strong>and</strong> Journal of <strong>Medicine</strong> 354:2103-2111.<br />
Barsyte-Lovejoy, D., Lau, S.K., Boutros, P.C., Khosravi, F., Jurisica, I., Andrulis, I.L., Tsao, M.S., <strong>and</strong> Penn, L.Z. (<strong>2006</strong>)<br />
The c-Myc oncogene directly induces H19 non-coding RNA by allele specific binding to potentiate tumorigenesis.<br />
Cancer Research 66:5330-5337.<br />
Onay, V.U., Briollais, L., Knight, J.A., Shi, E., Wang, Y., Wells, S., Li, H., Rajendram, I., Andrulis, I.L., <strong>and</strong> Ozcelik, H.<br />
(<strong>2006</strong>) SNP-SNP Interactions in Breast Cancer Susceptibility. BMC Cancer. 6:114.<br />
Yan, T., Wunder, J.S., Gokgoz, N., Seto, K., Bell, R.S. <strong>and</strong> Andrulis, I.L. (<strong>2006</strong>) hCDC4 variation in osteosarcoma.<br />
Cancer Genetics <strong>and</strong> Cytogenetics 169:138-142.<br />
McGuire, V., John, E.M., Felberg, A., Haile, R.W., Boyd, N.F., Thomas, D.C., Jenkins, M.A., Milne, R.L., Daly, M.B.,<br />
Ward, J., Terry, M.B., Andrulis, I.L., Knight, J.A., Godwin, A.K., Giles, G.G., kConFab Investigators, Southey, M.,<br />
West, D.W., Hopper, J.L., Whittemore, A.S. (<strong>2006</strong>) No increased risk of breast cancer associated with alcohol<br />
consumption among carriers of BRCA1 <strong>and</strong> BRCA2 mutations under age 50 years. Cancer Epidemiol, Biomarkers<br />
<strong>and</strong> Prev 15:1565-1567.<br />
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Mastracci, T.L., Shadeo, A., Colby, S.M., Tuck, A.B., O’Malley, F.P., Bull, S.B., Lam, W.L., <strong>and</strong> Andrulis, I.L. (<strong>2006</strong>)<br />
Genomic alterations in lobular neoplasia: CGH-microarray signature for neoplastic proliferation in the breast.<br />
Genes, Chromosomes <strong>and</strong> Cancer 45:1007-1017.<br />
Haile, R.W., Thomas, D.C., McGuire, V., Felberg, A., John, E.M., Milne, R.L., Hopper, J.L., Jenkins, M.A., Levine, A.J.,<br />
Daly, M.M., Buys, S.S., Senie, R.T., Andrulis, I.L., Knight, J.A., Godwin, A.K., Southey, M., McCredie, M.R.E., Giles,<br />
G.G., Andrews, L., Tucker, K., Miron, A., Apicella, C., Tesoriero, A., Bane, A., Pike, M.C., kConFab Investigators,<br />
Ontario Cancer Genetics Network Investigators, <strong>and</strong> Whittemore, A.S. (<strong>2006</strong>) BRCA1 <strong>and</strong> BRCA2 mutation carriers,<br />
oral contraceptive use <strong>and</strong> breast cancer before age 50. Cancer Epidemiol, Biomarkers <strong>and</strong> Prev.15:1863-1870.<br />
Bernstein, J.L., Seminara. D., John, E.M., Chenevix-Trench, G., Hopper, J., Lapinski, R.H., Andrulis, I.L., Knight, J.,<br />
Whittemore, A.S., West, D.W., Teraoka, S., Wallis, A. <strong>and</strong> Concannon, P. (<strong>2006</strong>) T7271G <strong>and</strong> IVS10-6T ATM gene<br />
mutations in a population-based family registry of breast cancer. Human Mutation. 27:1122-1128.<br />
Dr. Bharati Bapat<br />
Buongiorno, P., Pethe, V., Esufali, S., Bapat, B. Rac1 GTPase associates with beta-catenin/TCF transcription factor<br />
complex to modulate Wnt target gene activation. Keystone Symposium Meeting, “Wnt <strong>and</strong> beta-catenin signalling<br />
in development <strong>and</strong> disease” Snowbird, Utah, April <strong>2006</strong>.<br />
Perera, S., Bapat, B. The role of mismatch repair gene variants in HNPCC susceptibility. 97th <strong>Annual</strong> Meeting of the<br />
American Association for Cancer Research, Washington DC, April <strong>2006</strong>.<br />
Mrkonjic, M., Raptis, R., Pethe, V., Knight, J.A., Monga, N., Daftary, D., Younghusb<strong>and</strong>, B., Parfrey, P., Gallinger, S.<br />
Green, R., McLaughlin, J., Bapat, B. Association of MLH1 <strong>and</strong> MSH2 promoter polymorphisms <strong>and</strong> colorectal cancer<br />
risk. 97th <strong>Annual</strong> Meeting of the American Association for Cancer Research, Washington DC, April <strong>2006</strong>.<br />
Perera, S., Bapat, B. Functional analysis of inherited genetic variants associated with hereditary colorectal cancer<br />
predisposition. 55th <strong>Annual</strong> Meeting of the American Society of Human Genetics, Salt Lake City, Utah, October<br />
<strong>2005</strong>.<br />
Mrkonjic, M., Raptis, R., Knight, J.A., Pethe, V., Monga, N., Daftary, D., Younghusb<strong>and</strong>, B., Parfrey, P., Gallinger, S.<br />
Green, R., McLaughlin, J., Bapat, B. Association of MLH1 <strong>and</strong> MSH2 promoter polymorphisms <strong>and</strong> colorectal cancer<br />
risk: A population-based case-control study of Canadian CRC cases. 55th <strong>Annual</strong> Meeting of the American Society<br />
of Human Genetics, Salt Lake City, Utah, October <strong>2005</strong>.<br />
Charames, G, Bapat, B. COX-2 mediated inhibition of apoptosis in colon cancer. 96th <strong>Annual</strong> Meeting of the<br />
American Association for Cancer Research, Anaheim, CA, April <strong>2005</strong>.<br />
Dr. Terry Colgan<br />
Siu KWM, DeSouza LV, Dube V, Ghanny S, Guo J, Grigull J, Romaschin AD, Colgan TJ. Novel aspect: Validation<br />
of our previously discovered <strong>and</strong> identified endometrial cancer biomarkers by iTRAQ methodology on 40 samples<br />
<strong>and</strong> antigen/antibody recognition in tissue microarray format on 148 samples. International Mass Spectrometry<br />
Conference in Prague, <strong>2006</strong>.
Invited speaker: A Canadian tale of tissue proteomics. Presented at the Ontario Association of Pathologists 67th<br />
Meeting, Deerhurst, Ontario, May <strong>2005</strong>.<br />
Invited speaker: Liquid based cytology. Cervical Screening Day of McMaster University, Royal Botanical Gardens,<br />
Burlington, Ontario, May <strong>2005</strong>.<br />
Invited speaker: Implications of Implementing Revised Guidelines: Impact on Laboratories, the Ontario Cervical<br />
Screening Program (Cancer Care Ontario) on Implementing Revised Cervical Screening Guidelines, Royal York Hotel,<br />
Toronto, September <strong>2005</strong>.<br />
Opening address: Looking into the Crystal Ball, the Screening Lab in 2010. National Meeting of Provincial Cervical<br />
Screening Programmes, sponsored by Cancer Care Ontario, Queen’s Park, Toronto, September <strong>2005</strong>.<br />
Workshop participant: NCIC CTG Proteomics Retreat. National Cancer Institute of Canada, Toronto, Ontario, April<br />
<strong>2006</strong>.<br />
Invited speaker with Fern<strong>and</strong>es B.: Implementation, Workload Analysis <strong>and</strong> Next Steps in <strong>Laboratory</strong> <strong>Medicine</strong>.<br />
Ontario Association of Pathologists 68th Meeting, Collingwood, Ontario, June <strong>2006</strong>.<br />
Invited debater: Be it finally resolved that LBC has a role in cervical cancer screening. Society of Canadian<br />
Colposcopists, 20th <strong>Annual</strong> Meeting, Vancouver, June <strong>2006</strong>.<br />
Dr. Greg Denomme<br />
Branch DR, Shabani F, Denomme GA. Increased TGF� <strong>and</strong> PGE2 Production Characterizes Cytokine Production<br />
Following Rh Immune Globulin Prophylaxis. Transfusion <strong>Medicine</strong> 15:347-348, <strong>2005</strong>.<br />
Pendergrast J, Denomme GA. Requests for phenotyped red blood cells received by Canadian Blood Services,<br />
Toronto Regional Office. Transfusion <strong>Medicine</strong> 15:355-356, <strong>2005</strong>.<br />
Blackall DP, Oza KK, Arndt PA, Garratty G, Denomme GA. Hemolytic disease of the newborn due to anti-Ge3:<br />
combined antibody-dependent hemolysis <strong>and</strong> erythroid precursor inhibition. Transfusion 45(3S):6A, <strong>2005</strong>.<br />
Judd J, Dake LR, Denomme GA. Confounding serological <strong>and</strong> molecular data in the investigation of Rh typing<br />
discrepancies. Transfusion 45(3S):130A, <strong>2005</strong><br />
Su B, Chan HHW, Branch DR, Denomme GA. IVIG down-regulates LPS-induced TNF� production via inhibition of I�B�<br />
activation: a possible mechanism of action in the treatment of bacterial infections. American Society of Hematology,<br />
<strong>Annual</strong> Meeting, New Orleans, LA. Blood 106 (Part 1):628a, <strong>2005</strong>.<br />
Chan HHW, Su B, Li W, Kelton JG, Denomme GA. Intravenous immunoglobulin does not increase RNA expression of<br />
Fc�RIIb in purified monocytes. American Society of Hematology, <strong>Annual</strong> Meeting, New Orleans, LA. Blood 106 (Part<br />
2):52b, <strong>2005</strong>.<br />
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35
Hemolytic disease of the newborn due to anti-Ge3: combined antibody-dependent hemolysis <strong>and</strong> erythroid<br />
precursor inhibition. American Association of Blood Banks <strong>Annual</strong> Meeting, Seattle, WA, October 17, <strong>2005</strong><br />
(Abstract published - Transfusion 45 (3S):6A, <strong>2005</strong>.<br />
Inhibition of erythroid progenitor cell growth by antibodies against determinants on glycophorin C. American<br />
Association of Blood Banks <strong>Annual</strong> Meeting, Seattle, WA, October 18, <strong>2005</strong> (Abstract published - Transfusion 45<br />
(3S):28A, <strong>2005</strong>)<br />
Distribution of microdeletions in DAZ (Deleted in Azoospermia) family genes located on Y-chromosome AZF region<br />
(Azoospermic Factor) in patients with infertility. American Society for Reproductive <strong>Medicine</strong> <strong>and</strong> the Canadian<br />
Fertility <strong>and</strong> Andrology Society, Montreal, PQ, October <strong>2005</strong><br />
The mechanism of Rh-immune globulin prophylaxis involves significant increases in the immunosuppressive<br />
cytokines TGF� <strong>and</strong> PGE2. American Society for Hematology, <strong>Annual</strong> Meeting, Atlanta GA, (Abstract published<br />
- Blood 106 (Part 1):154, <strong>2005</strong>), December <strong>2005</strong>.<br />
Invited Speaker: Practical Applications of Molecular Testing for Blood Groups - When <strong>and</strong> Why. SSCC Education<br />
Session, American Association of Blood Banks, <strong>Annual</strong> Meeting, Seattle, WA, October <strong>2005</strong>.<br />
Invited Speaker: RHD DNA Diagnostics ¬– Where are we now? Transfusion Safety <strong>and</strong> New Technologies,<br />
Shenzhen Blood Center, Shenzhen, P.R.China, November <strong>2005</strong>.<br />
Invited Speaker: Intrauterine Transfusion. Lunch ‘n’ Learn, McMaster University Medical Centre, September <strong>2005</strong>.<br />
Invited Speaker: The Effect of Anti-Kell on Erythropoiesis, Vascular Biology Research Group, McMaster University,<br />
Hamilton, ON, November <strong>2005</strong>.<br />
Dr. Eleftherios Diam<strong>and</strong>is<br />
Oikonomopoulou K, Hansen K, Saifeddine M, Diam<strong>and</strong>is EP, Hollenberg MD. Cell signaling via proteinase-activated<br />
receptors (PARS): A new role for kallikreins. 4th Gen Meet Intl Proteolysis Soc <strong>2005</strong>;79, #PI 6.<br />
Komatsu N, Suga Y, Saijoh K, Liu AC, Khan S, Mizuno Y, Ikeda S, Jayakumar A, Clayman GL, Shirasaki F, Takehara<br />
K, Diam<strong>and</strong>is EP. Elevated Human Tissue Kallikrein Levels in the Stratum Corneum <strong>and</strong> Serum of Peeling Skin<br />
Syndrome-Type B Patients Suggests an Over-Desquamation of Corneocytes. 67th Society for Invest Dermatol <strong>2006</strong>;<br />
#348.<br />
Paliouras M, Diam<strong>and</strong>is EP. Coordinated hormone regulation of multiple kallikreins in breast cancer cell lines. Proc<br />
AACR <strong>2006</strong>; #91.<br />
White NMA, Yousef GM, Diam<strong>and</strong>is EP, Doré JJ. The human kallikrein gene 6 (KLK6) in combination with CA125 is<br />
a more sensitive marker for ovarian cancer than CA125 alone. Proc AACR <strong>2006</strong>; #94<br />
Shan SJC, Katsaros K, Paliouras M, Rigault I, Puopolo M, Diam<strong>and</strong>is EP. Up-regulation of human tissue kallikrein 6 in<br />
ovarian carcinoma. Proc AACR <strong>2006</strong>; #102.
Paliouras M, Diam<strong>and</strong>is EP. Investigating the role of intracellular signaling pathways in regulating kallikrein<br />
expression. Proc AACR <strong>2006</strong>; #1655.<br />
Oikonomopoulou K, Hansen KK, Saifeddine M, Tea I, Andrade-Gordon P, Cottrell GS, Bunnett NW, Diam<strong>and</strong>is EP,<br />
Hollenberg MD. Kallikrein 14 signaling through proteinase-activated receptors. Proc AACR <strong>2006</strong>; #1686.<br />
Memari M, Diam<strong>and</strong>is EP, Van der Kwast T. Immunohistochemical localization <strong>and</strong> expression profiling of human<br />
kallikrein 12 in human prostate cancer tissues. Proc AACR <strong>2006</strong>; #1980.<br />
Shaw JL, Grass L, Soosaipillai A, Sotiropoulou G, Diam<strong>and</strong>is EP. Development of an immunoassay for human<br />
kallikrein 15, a potential prostate <strong>and</strong> ovarian cancer biomarker. Proc AACR <strong>2006</strong>; #1985.<br />
Memari N, Grass L, Karakucuk EI, Shaw JL, Diam<strong>and</strong>is EP. Protein expression, antibody generation, <strong>and</strong> development<br />
of a highly sensitive immunoassay for the detection of human tissue kallikrein 9. Proc AACR <strong>2006</strong>; #2889.<br />
Sardana G, Marshall J, Diam<strong>and</strong>is EP. Identification <strong>and</strong> characterization of novel c<strong>and</strong>idate prostate cancer<br />
biomarkers through proteomic analysis of the secretome of three prostate cancer cell lines. Proc AACR <strong>2006</strong>;<br />
#3572.<br />
Petraki C, Papanastasiou PA, Karavana VN, Diam<strong>and</strong>is EP. Immunohistochemical expression of human tissue<br />
kallikreins in neoplasms of various organs. Proc AACR <strong>2006</strong>; #4358.<br />
Emami N, Michael IP, Diam<strong>and</strong>is EP. Proteolytic cascades of human tissue kallikreins. Proc AACR <strong>2006</strong>; #4368.<br />
Oikonomopoulou K, Shannon P, Petraki CD, Diam<strong>and</strong>is EP. Immunohistochemical localization of kallikrein 6 in brain<br />
tumors. Proc AACR <strong>2006</strong>; #4488.<br />
Shan SJC, Scorilas A, Soosaipillai A, Katsaros D, Rigault I, Puopolo M, Diam<strong>and</strong>is EP. Human tissue kallikrein 7 overexpression<br />
in ovarian carcinoma: a novel marker of unfavorable prognosis. Proc AACR <strong>2006</strong>; #4503.<br />
Simon I, Diam<strong>and</strong>is EP, Katsaros D, Kim NW, Wolfert RL. B7-H4 (DD-O110) protein is over-expressed in early-stage<br />
ovarian cancer tumor tissue. Proc AACR <strong>2006</strong>; #4505.<br />
Kundig C, Cloutier SM, Aellen S, Felber LM, Chagas JR, Gygi CM, Jichlinski P, Leisinger H-J, Diam<strong>and</strong>is EP, Deperthes<br />
D. Human kallikrein 2 (hK2) inhibitors suppress tumor growth of prostate cancer xenografts in nude mice. J Urol<br />
(suppl) <strong>2006</strong>;175:263, #815.<br />
Heshmat SM, Jarvi K, Mullen B, Diam<strong>and</strong>is EP, Lo KC. Seminal plasma lipocalin type PGDS: A potential marker for<br />
the diagnosis of obstructive azoospermia. J Urol (Suppl) <strong>2006</strong>;175:523, #1623.<br />
Oikonomopoulou K, Hansen K, Saifeddine M, Diam<strong>and</strong>is EP, Hollenberg MD. Kallikrein signaling in cancer via<br />
proteinase-activated receptors. NIH Proteomics Int Group <strong>2006</strong>;#85.<br />
Dr. Bernard Fern<strong>and</strong>es<br />
Workload <strong>Report</strong>ing in <strong>Laboratory</strong> <strong>Medicine</strong>. Ontario Association of <strong>Pathology</strong>, Collingwood, ON, June 1-3, <strong>2006</strong>.<br />
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37
Dr. Steven Gallinger<br />
The Fifth Princess Margaret Hospital Conference: New Developments in Cancer Management. Keynote Presentation<br />
“Genetic predisposition to gastrointestinal cancer: Progress <strong>and</strong> frustration”. Toronto, September <strong>2005</strong>.<br />
IMS Lecture Series-Critical Care: Bench to Bedside. “Cancer genetics” Toronto General Hospital March <strong>2006</strong>.<br />
Cotterchio M, Boucher B, Manno M, Gallinger S. Dietary phytoestrogen intake is associated with reduced colorectal<br />
cancer risk. SER-CSEB Meeting, Toronto, Ontario. June 27-30, <strong>2005</strong> Am J Epidemiol <strong>2005</strong>: 161.<br />
Fazio L, Cotterchio M, Manno J, McLaughlin J, Gallinger S. Association between colonic screening subject<br />
characteristics <strong>and</strong> stage of colorectal cancer. SER-CSEB Meeting, Toronto Ontario. June 27-30, <strong>2005</strong> Am J<br />
Epidemiol <strong>2005</strong>: 161.<br />
Tucker A, Cotterchio M, Gallinger S, Kreiger N, McLaughlin J, Koo M. Access to educational colorectal cancer<br />
website <strong>and</strong> subject participation in the Ontario Familial Colorectal Cancer Registry (OFCCR). SER-CSEB Meeting,<br />
Toronto Ontario. June 27-30, <strong>2005</strong> Am J Epidemiol <strong>2005</strong>: 161.<br />
Ramji F, Cotterchio M, Manno M, Rabeneck L, Gallinger S. Association between subject factors <strong>and</strong> colorectal<br />
cancer screening participation in Ontario Canada. SER-CSEB Meeting, Toronto Ontario. June 27-30, <strong>2005</strong> Am J<br />
Epidemiol <strong>2005</strong>: 161.<br />
Dr. Marc Grynpas<br />
3rd International Conference on Children’s Bone Health, Sorrento, Italy. “The use of bone quality parameters in<br />
bone biopsies of children with primary osteoporosis”, May <strong>2005</strong>.<br />
Universite Catholique de Louvain, “group de Recherché et d’etude en chirurgie Orthopedique” Bruxelles,<br />
“Le degree de mineralization de la matrice osseuse”, October <strong>2005</strong>.<br />
Universite Catholique de Louvain, “group de Recherché et d’etude en chirurgie Orthopedique” Bruxelles, “ Le<br />
mineral osseux”, October <strong>2005</strong>.<br />
Hunt T, Bhola P, Moreno L, Jurisicova A, Grynpas MD. Differences in bone fragility among 5 inbred mice strains.<br />
<strong>Pathology</strong> Poster Session, University of Toronto, June <strong>2005</strong>.<br />
Moreno L, Cheung A <strong>and</strong> Grynpas MD. The role of creep in the sex differences of long bone resistance to fatigue<br />
failure. XXth Congress of the International Society of Biomechanics <strong>and</strong> 29th <strong>Annual</strong> Meeting of the American<br />
Society of Biomechanics, Clevel<strong>and</strong>, Ohio, USA, July <strong>2005</strong>.<br />
Wang SX, Laverty S, Grynpas MD. Quantifying joint changes in an OA model using 3D <strong>and</strong> 2D imaging techniques.<br />
International Symposium on Quality of Bone <strong>and</strong> Scaffold Biomaterials Evaluated by microCT, pQCT <strong>and</strong> MRI, Hong<br />
Kong, October <strong>2005</strong>.<br />
Holmes C, Khan TS, Owen C, Grynpas MD, Stanford WL. Characterization of the age-dependent osteoporotic<br />
phenotype in Sca-1/Ly6A null mice. Challenges in Regenerative <strong>Medicine</strong> (ChaRM), Toronto, October <strong>2005</strong>.
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. The Effects of Vanadium Treatment on Diabetic Osteoporotic<br />
Bone Model. SLRI Retreat, YMCA, Geneva Park Conference Centre, Toronto, October <strong>2005</strong>.<br />
Holmes C, Khan TS, Owen C, Grynpas MD, Stanford WL. Characterization of age-dependent osteoporotic<br />
phenotype of Stem Cell Antigen-1 Null Mice. Canadian Arthritis Network <strong>2005</strong> <strong>Annual</strong> Scientific Conference,<br />
Gatineau, Quebec, October <strong>2005</strong>.<br />
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. The Effects of Vanadium Treatment on Diabetic <strong>and</strong> Osteoporotic<br />
Bone Model. IBBME Seminar, University of Toronto, December <strong>2005</strong>.<br />
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. (<strong>2006</strong>) The Effects of Vanadium Treatment on Diabetic <strong>and</strong><br />
Osteoporotic Bone Model. MSE seminar, University of Toronto, March <strong>2006</strong>.<br />
Wise L, Sukhu B, Benito A, Nunez G, Perez G, Tilly J, Jurisicova A, Grynpas MD. Comparison of Bone Quality in<br />
Mice Deficient in Pro-Apoptotic Members of the BCL-2 Gene Family. 23rd European Calcified Tissue Society (ECTS)<br />
Meeting, Prague, Czech Republic, May <strong>2006</strong>.<br />
Khan TS, Holmes CM, Grynpas MD <strong>and</strong> Stanford WL. Characterization of age-dependent osteoporosis in Sca-1/<br />
Ly6A null mice. 23rd European Calcified Tissue Society (ECTS) Meeting, Prague, Czech Republic, May <strong>2006</strong>.<br />
Khan TS, Holmes CM, Grynpas MD <strong>and</strong> Stanford WL. Characterization of the Age-related osteoporotic phenotype<br />
in Sca-1 null mice. 23rd European Calcified Tissue Society (ECTS) Meeting, Prague, Czech Republic, May <strong>2006</strong>.<br />
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. Effects of Vanadium Treatment on Bone Qualities on a<br />
Combined Osteoporotic Diabetic Rat Model. Banting <strong>and</strong> Best Scientific Day, Sunnybrook Health Science Centre,<br />
May <strong>2006</strong>.<br />
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. Effects of Vanadium Treatment on Bone Qualities on a<br />
Combined Osteoporotic Diabetic Rat Model. University of Toronto, Bone <strong>and</strong> Mineral Group-Research Day, May<br />
<strong>2006</strong>.<br />
Neufeld S, Rowe E, Milton KR, Carran J, Wainman S, Anastassiades T, Grynpas MD. The Effects of N-butyryl<br />
Glucosamine on Bone Quality in an Ovariectomized Rat Model. University of Toronto, Bone <strong>and</strong> Mineral Group-<br />
Research Day, May <strong>2006</strong>.<br />
Hunt T, Vieth R, K<strong>and</strong>el R, Grynpas MD. Can Vitamin D affect the Progession of Osteoarthritis in a Guinea Pig<br />
Model? University of Toronto, Bone <strong>and</strong> Mineral Group-Research Day, May <strong>2006</strong>.<br />
Neufeld S, Rowe E, Milton KR, Carran J, Wainman S, Anastassiades T, Grynpas MD. The Effects of N-butyryl<br />
Glucosamine on Bone Quality in an Ovariectomized Rat Model Canadian Connective Tissue Conference (CCTC),<br />
University of Ottawa, May <strong>2006</strong>.<br />
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. Effects of Vanadium Treatment on Bone Qualities on a<br />
Combined Osteoporotic Diabetic Rat Model. Canadian Connective Tissue Conference (CCTC), Ottawa, May <strong>2006</strong>.<br />
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39
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. The Effects of Vanadium Treatment on Bone Qualities on a<br />
Combined Osteoporotic <strong>and</strong> Diabetic Female Rat Model. International Osteoporosis Foundation. (IOF) World<br />
Congress on Osteoporosis, Toronto, June <strong>2006</strong>.<br />
Khan TS, Holmes CM, Grynpas MD <strong>and</strong> Stanford WL. Characterization of the age-dependent osteoporotic<br />
phenotype in the Sca-1/Ly6A null mice. International Osteoporosis Foundation. (IOF) World Congress on<br />
Osteoporosis, Toronto, June <strong>2006</strong>.<br />
Khan TS, Holmes CM, Grynpas MD <strong>and</strong> Stanford WL. Characterization of the Age-related osteoporotic phenotype<br />
in Sca-1-/- mice. International Osteoporosis Foundation. (IOF) World Congress on Osteoporosis, Toronto, June<br />
<strong>2006</strong>.<br />
Wise L, Sukhu B, Benito A, Nunez G, Perez G, Tilly J, Jurisicova A, Grynpas MD.<br />
(<strong>2006</strong>) Comparison of Bone Quality in Mice Deficient in Pro-Apoptotic Members of the BCL-2 Gene Family.<br />
International Osteoporosis Foundation. (IOF) World Congress on Osteoporosis, Toronto, June <strong>2006</strong>.<br />
Chiu A, Battell M, Yuen V, McNeill J, Grynpas MD. The Effects of Vanadium Treatment on Bone Qualities on a<br />
Combined Osteoporotic <strong>and</strong> Diabetic Female Rat Model. IBBME Scientific Day, University of Toronto, June <strong>2006</strong>.<br />
Holmes C, Khan TS, Grynpas MD, Stanford WL. Characterization of age-dependent osteoporosis in Sca-1/Ly6A null<br />
mice. International Society of Stem Cell Research (ISSCR), Toronto, June <strong>2006</strong>.<br />
Dr. Barry Hoffman<br />
Likhodii, S.S., Moller, C. <strong>and</strong> Hoffman, B. A software tool to facilitate method comparison <strong>and</strong> bias estimation.<br />
50th <strong>Annual</strong> Conference of the Canadian Society of Clinical Chemists. Victoria, British Columbia, June <strong>2006</strong>.<br />
Li, H., Seiden-Long, I., Bromberg, IL., Hoffman, BR. Three GFR estimation formulae yield similar but frequently<br />
inaccurate predictions of the creatinine clearance. 50th <strong>Annual</strong> Conference of the Canadian Society of Clinical<br />
Chemists. Victoria, British Columbia, June <strong>2006</strong>.<br />
Dr. Rita K<strong>and</strong>el<br />
Towards Bioengineering a Scaffold-Free Nucleus Pulposus. ECM VI/SRN I Spinal Motion Segment: From Basic<br />
Science to Clinical Application. Davos Switzerl<strong>and</strong>. July <strong>2005</strong>.<br />
Tissue Engineering an Intervertebral Disc Using Silk Scaffold. First <strong>Annual</strong> TERC Review. Medford, MA. August<br />
<strong>2005</strong>.<br />
Soft Tissue Challenges. <strong>Pathology</strong> Update Day, University of Toronto. Toronto, ON. November <strong>2005</strong>.<br />
In Vitro Model of Nucleus Pulposus Degeneration. Abbot Webex Presentation. Abbot Park, IL. November <strong>2005</strong>.<br />
Current Uses of Stem Cell Therapies in Regenerative <strong>Medicine</strong>. <strong>2006</strong> Toronto Regenerative <strong>Medicine</strong> Day. Toronto,<br />
ON. April <strong>2006</strong>.
Tissue Engineering of joint replacement; a new approach. Bone <strong>and</strong> Mineral Group Research Day, University of<br />
Toronto. Toronto, ON. May <strong>2006</strong>.<br />
Resurfacing focal cartilage defects with biphasic implants in a sheep model. Bioengineering for the Restoration of<br />
Joint Function Workshop, Canadian Arthritis Network, Vancouver, British Columbia. June <strong>2006</strong>.<br />
Consensus Meeting for Cartilage Repair Grading System. Leuven, Belgium. June <strong>2006</strong>.<br />
K<strong>and</strong>el R, Li SQ, Werier J, Kauzman A, Ferguson P, Bell R, Wunder J. Abnormalities in Cell Cycle Proteins in Giant<br />
Cell Tumors. 11th <strong>Annual</strong> CTOS Meeting. Boca Raton, FL, USA. November <strong>2005</strong>.<br />
De Croos JNA, Jang B, Grynpas MD, Pilliar RM, K<strong>and</strong>el RA. Early Upregulation of EGR-1 <strong>and</strong> MT1-MMP after Cyclic<br />
Mechanical Compression of In Vitro Grown Chondrocytes. 52st <strong>Annual</strong> Meeting of the Orthopaedic Research<br />
Society. Chicago, IL. March <strong>2006</strong>.<br />
Chang G, K<strong>and</strong>el RA, Jin HJ, Vunjak-Novakovic, G, Kaplan D. Annulus Fibrosus Cells Form Tissues when Grown in<br />
Porous Silk Scaffold in a Bioreactor. 52st <strong>Annual</strong> Meeting of the Orthopaedic Research Society. Chicago, IL. March<br />
<strong>2006</strong>.<br />
St-Pierre JP, Cruz LC, Grynpas MD, Pilliar RM, K<strong>and</strong>el RA. Substrates Affect the Formation of the Calcified Zone in<br />
Articular Cartilage Formed In Vitro. 52st <strong>Annual</strong> Meeting of the Orthopaedic Research Society. Chicago, IL. March<br />
<strong>2006</strong>.<br />
Gan L, Tse C, Pilliar RM, K<strong>and</strong>el RA. Low-Power Laser Stimulation Improves Cartilaginous Tissue Formation In Vitro.<br />
52st <strong>Annual</strong> Meeting of the Orthopaedic Research Society. Chicago, IL. March <strong>2006</strong>.<br />
Séguin CA, Pilliar RM, K<strong>and</strong>el RA. TNF� Stimulated Activation of MMP-2 in Nucleus Pulposus Cells Occurs through<br />
EGR-1 Mediated Transcription of MT1-MMP. 52st <strong>Annual</strong> Meeting of the Orthopaedic Research Society. Chicago,<br />
IL. March <strong>2006</strong>.<br />
White L, Marshall S, K<strong>and</strong>el RA, Hurtig M. T2 MRI Mapping for Differentiation of Hyaline Cartilage versus Repair<br />
Tissue after Cartilage Repair Procedures. 52st <strong>Annual</strong> Meeting of the Orthopaedic Research Society. Chicago, IL.<br />
March <strong>2006</strong>.<br />
Hurtig M, K<strong>and</strong>el RA, Grynpas M, Pilliar R, Lee J, Waldman S, Zalzal P. Survival <strong>and</strong> Adaptation of Biphasic<br />
Cartilage-Calcium Polyphosphate Implants in a Sheep Model. 52st <strong>Annual</strong> Meeting of the Orthopaedic Research<br />
Society. Chicago, IL. March <strong>2006</strong>.<br />
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Dr. Sarah Keating<br />
Keating, S., Edmondson, N., Bocking, A., Rizek, R., Watson, C., Machin, G. The prevalence of chronic deciduitis in<br />
cases of preterm labour. Society for Pediatric <strong>Pathology</strong> Atlanta, Georgia, February <strong>2006</strong>.<br />
Keating, S., Kingdom, J., Toal, M., Chan, C., Windrim, R., Machin, G. Correlation of placental pathology with<br />
uterine artery Doppler findings in high risk pregnancies. Society for Pediatric <strong>Pathology</strong> Atlanta, Georgia, February<br />
<strong>2006</strong>.<br />
Shannon, P., Halliday, W., Viero, S., Keating, S. Spinal cord lesions in intrauterine asphyxia. Society for Pediatric<br />
<strong>Pathology</strong> Atlanta, Georgia, February <strong>2006</strong>.<br />
Viero, S., Whittle, W.L., Shin, V., Keating, S., Kingdom, J. <strong>Pathology</strong> of echogenic cystic lesions of the placenta:<br />
a study utilizing postdelivery sonographically guided needle localization. Society for Pediatric <strong>Pathology</strong> Atlanta,<br />
Georgia, February <strong>2006</strong>.<br />
Dr. Elena Kolomietz<br />
<strong>2006</strong> PLM Genetic rounds, MSH: Array CGH: Exp<strong>and</strong>ing resolution of cytogenetic analysis.<br />
<strong>2005</strong> PLM Genetic rounds, MSH: Recent advances in X-chromosome inactivation.<br />
<strong>2005</strong> Gr<strong>and</strong> rounds presentation, Lakeridge Health Corporation, Oshawa: Recent advances in Xchromosome<br />
inactivation. Prenatal diagnosis of de novo X; autosome translocation.<br />
Prenatal diagnosis of acute promyelocytic leukemia in a fetus at 28 weeks’ gestation. ASHG meeting, Salt Lake City,<br />
<strong>2005</strong>.<br />
Subtelomeric familial translocation t(8;12)(p23.1;p13.1) leading to deletion 8pter-p23.1 <strong>and</strong> duplication 12pterp13.1:<br />
molecular cytogenetic analysis <strong>and</strong> clinical phenotype in two siblings. ASHG meeting, Salt Lake City, <strong>2005</strong>.<br />
Dr. Iona Leong<br />
Crescent Oral Surgery sponsored seminar ‘Common Lesions of the Oral Mucosa November <strong>2005</strong>.<br />
Halton-Peel Dental Association invited speaker, lecture ‘Common Oral Mucosal Lesions’ May <strong>2006</strong>.
Dr. Christina MacMillan<br />
Expression of Caspase-3, Survivin, <strong>and</strong> Bcl-2 in Adenoid Cystic Carcinoma using Tissue Microarray Technology.<br />
Makino A., MacMillan C., Perez-Ordonez B. Modern <strong>Pathology</strong>. Poster Session Head <strong>and</strong> Neck, Poster Board #94,<br />
Feb 28/05, United States <strong>and</strong> Canadian Academy of <strong>Pathology</strong> <strong>Annual</strong> Meeting, San Antonio <strong>2005</strong>.<br />
A. Zhou, PP Reis, MA Sukhai, J Freeman, C MacMillan, S Kamel-Reid BRAF <strong>and</strong> ret/ptc alterations in Hurthle cell<br />
tumors of the thyroid. Poster at Summer<br />
Student Research Day, Department of Pathobiology <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>, University of Toronto, August <strong>2005</strong>.<br />
Dr. David Mock<br />
University of Western Ontario, Faculty of <strong>Medicine</strong> & Dentistry, “ Economics of<br />
Canadian Schools of Dentistry”, London, Ontario, <strong>2005</strong><br />
Canadian Dental Association, “Ensuring a Sustainable Future for Academic Dentistry in<br />
Canada”, Ottawa Ontario, <strong>2005</strong><br />
P.G. Anderson Study Club, “The TMD Delemma”, Toronto, Ontario, <strong>2006</strong>.<br />
Ontario Medical Association, Section on Physical <strong>Medicine</strong> & Rehabilitation, “Post-<br />
Traumatic Temporom<strong>and</strong>ibular Disorders”, Toronto, Ontario, <strong>2006</strong>.<br />
Dr. Frances O’Malley<br />
“ A new role for histopathology in breast cancer: BRCA risk stratification.” <strong>Pathology</strong> Update CME symposium,<br />
Department of <strong>Laboratory</strong> <strong>Medicine</strong> <strong>and</strong> Pathobiology, University of Toronto, Toronto, November <strong>2005</strong>.<br />
“HER2/neu as a predictor of response to anthracycline based chemotherapy: data from<br />
the MA5 NCIC clinical trial. University of Toronto Breast Cancer Symposium, Toronto, November <strong>2005</strong>.<br />
Co-Chair, Eastern Canada Consultants Workshop on HER2 testing, Toronto, November <strong>2005</strong>.<br />
Co-Moderator, proffered papers, breast pathology section, United States <strong>and</strong> Canadian Academy of Pathologists<br />
meeting Atlanta, February <strong>2006</strong>.<br />
Royal College of Surgeons <strong>and</strong> Physicians of Canada sponsored speaker: OAP slide seminar in breast pathology,<br />
June <strong>2006</strong>.<br />
Co-Chair, Eastern Canada Consultants Follow-up Workshop on HER2 testing, Toronto, June <strong>2006</strong>.<br />
Chapman JW, Jasani B, Ibrahim M, Miller K, Murray D, Hewlett B, Daidone MG, Allred C, Hammond E, Li D, Sweep<br />
F, O’Malley FP, Kelly J, Goss P. St<strong>and</strong>ardization of estrogen <strong>and</strong> progesterone receptor assay values. Breast Cancer<br />
Research <strong>and</strong> Treatment <strong>2005</strong>; 94(S1):S242. Abstract #5101.<br />
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AL Bane, S Tjan, N Weerasooriya, IL Andrulis, FP O’Malley. BRCA2 associated breast cancers exhibit a luminal<br />
phenotype despite their high histologic grade. United states <strong>and</strong> Canadian Academy of Pathologists meeting,<br />
Atlanta, February 13, <strong>2006</strong>. Mod Pathol; 83, 21A, <strong>2006</strong>.<br />
A.M. Chiarelli, V. Majpruz, R. Shumak, F.P. O’Malley, V. Mai. The contribution of clinical breast examination on<br />
prognostic measures of effectiveness in a breast screening program. Presented at CBCRA, Reasons for Hope, 4th<br />
Scientific Conference, Montreal, May 6-8, <strong>2006</strong> <strong>and</strong> International Breast Cancer Screening Network (ISBN) Biennial<br />
Meeting, Ottawa, May <strong>2006</strong>.<br />
A.M. Chiarelli, N. Malek, G. Glendon, P.G. Ritvo, J.A. Knight, V. Kirsh, F.P. O’Malley, I.L. Andrulis. Screening<br />
behaviours <strong>and</strong> outcomes among relatives of women with breast cancer. Presented at CBCRA, Reasons for Hope,<br />
4th Scientific Conference, Montreal, May, <strong>2006</strong>.<br />
F.P. O’Malley, T. Thomson, J. Julian, C. Have, R. Cosby, K. Gelmon, I. Andrulis, T. Whelan for Project 4, Stream of<br />
Excellence Program: Molecular Changes in Breast Cancer Accuracy of HER2/neu Testing in a Population Based<br />
Study of Patients Treated with Trastuzumab. Presented at CBCRA, Reasons for Hope, 4th Scientific Conference,<br />
Montreal, May <strong>2006</strong>.<br />
V.A. Kirsh, A.M. Chiarelli, F.P. O’Malley, R.S. Shumak, N.F. Boyd. Tumour characteristics associated with detection of<br />
breast cancer. Presented at CBCRA, Reasons for Hope, 4th Scientific Conference, Montreal, May, <strong>2006</strong>.<br />
S. Chia, D.G. Huntsman, F.P. O’Malley, D. Tu, L.E. Shepherd, M.N. Levine, V.H. Bramwell, I.L. Andrulis, K.I. Pritchard.<br />
Prognostic <strong>and</strong> Predictive Significance of HER-2 in a R<strong>and</strong>omized Trial Comparing CEF to CMF in Pre-menopausal<br />
Node Positive Breast Cancer (NCIC CTG MA.5 Trial). Presented at CBCRA, Reasons for Hope, 4th Scientific<br />
Conference, Montreal, May <strong>2006</strong>.<br />
Dr. Hilmi Özçelik<br />
Invited Speaker. Queens University, Cancer Center” SNPs, protein function <strong>and</strong> breast cancer predisposition”,<br />
Kingston, Ontario, May <strong>2005</strong>.<br />
Invited Speaker. International Medical Care & Diagnostic Conference & Exhibition. “Genetic variation, protein<br />
function <strong>and</strong> predisposition to breast cancer”, Dubai, United Arab Emirates, September <strong>2005</strong>.<br />
Invited working group member <strong>and</strong> presenter: Familial Breast Cancer Registry, Gene Discovery <strong>and</strong> Polymorphism<br />
Working Groups, San Francisco CA, November <strong>2005</strong>.<br />
Invited working group member <strong>and</strong> presenter: Familial Breast Cancer Registry, Gene<br />
Discovery <strong>and</strong> Polymorphism Working Groups, New York NY, April <strong>2006</strong>.
Dr. Aaron Pollett<br />
A Pollett, J McLaughlin, E. Hollowaty, K Leonard. <strong>Pathology</strong> <strong>Report</strong>ing to the Ontario Cancer Registry 1996 – 2003:<br />
Evaluating the impact of Rapid Case Ascertainment. Poster presentation, CrCIHRt <strong>Annual</strong> General Meeting,<br />
Toronto, <strong>2005</strong>.<br />
A. Gupta, R. Haddad, J. Bacani, C. O’Brien, A. Pollett, S. Gallinger <strong>and</strong> C. Swallow. Inadequate lymph node retrieval<br />
(LNR) for gastric cancer across the Province of Ontario <strong>and</strong> at a tertiary care cancer center. Platform presentation,<br />
Canadian Society of Surgical Oncology, Montreal, <strong>2005</strong>.<br />
Invited lecture: Colorectal carcinoma – indications for microsatellite instability (MSI) testing, <strong>Pathology</strong> Update <strong>2005</strong>,<br />
Toronto, November <strong>2005</strong>.<br />
Dr. Kenneth Pritzker<br />
Hauck TS, Padmawar PA, Canteenwala T, Pritzker KPH, Chiang LY: Characterization of chemically grafted carbon<br />
nanotubes by EELS spectroscopy. Photonics North, Toronto, Canada, September <strong>2005</strong>.<br />
So G, Karotki A, Verma S, Hauck TS, Wilson B, Pritzker KPH, Chiang L: Singlet oxygen production by amphiphilic<br />
C60 derivatives <strong>and</strong> its correlation to cell cytotoxicity in vitro. Photonics North, Toronto, Canada, September <strong>2005</strong>.<br />
Pritzker KPH: OARSI Osteoarthritis Cartilage <strong>Pathology</strong> Grading System: Development <strong>and</strong> Implementation.<br />
International Skeletal Society, Singapore, September <strong>2005</strong>.<br />
Chiang L, Pritzker KPH, Wilson B: Two-photon absorption approach toward biophotonicapplication of<br />
amphiphilic fullerene-fluorene adducts. Symposium “Fullerenes <strong>and</strong> Carbon Nanotube Based Materials in <strong>Medicine</strong><br />
<strong>and</strong> Biology” of the 209th Meeting of The Electrochemical Society, Adams Mark Denver Hotel, Denver, Colorado,<br />
May <strong>2006</strong>.<br />
Pritzker KPH: Why animal models of osteoarthritis? CAN, International Conference on Preclinical Models of<br />
Osteoarthritis, Montreal, May <strong>2006</strong>.<br />
Pritzker KPH: Nonhuman primate models of osteoarthritis. CAN, International Conference on Preclinical Models of<br />
Osteoarthritis, Montreal, May <strong>2006</strong>.<br />
Las Heras F, Inman RD, Tsui F, Pritzker KPH: Chondrocyte morphology supports ank mice as an animal model<br />
for osteoarthritis (poster presentation). CAN, International Conference on Preclinical Models of Osteoarthritis,<br />
Montreal, May <strong>2006</strong>.<br />
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Dr. Robert Riddell<br />
CAP Meeting, Victoria, BC. Diagnostic problems in Inflammatory Bowel Disease,<br />
June <strong>2005</strong>.<br />
IAP <strong>2005</strong> Congress Meeting, Beijing China. Dysplasia in the GI Tract, August <strong>2005</strong>.<br />
The Banff <strong>Pathology</strong> Course. Pits in the diagnosis of IBD, Barrett’s esophagus dysplasia, Gastritis, Gastric Neoplasia<br />
<strong>and</strong> Endoscopic Mucosal Resection, September, <strong>2005</strong>.<br />
World Congress of Gastroenterology <strong>2005</strong>. Toward <strong>and</strong> integrated clinical, molecular <strong>and</strong> serological<br />
classification of inflammatory bowel disease: <strong>Report</strong> of a Working Party of the <strong>2005</strong> Montreal World Congress of<br />
Gastroenterology, September <strong>2005</strong>.<br />
Path Update <strong>2005</strong>. University of Toronto Conference Centre. Gastrointestinal Stromal Tumors (GISTs): A histology<br />
or molecular diagnosis? November <strong>2005</strong>.<br />
Digestive Diseases for Physicians <strong>and</strong> Surgeons. Update on Inflammatory Bowel Disease, “An Update on dysplasia<br />
in IBD, November <strong>2005</strong>.<br />
Repubblic Italiana. In nome della Legge, noi, Prof. Dott. Pasquale Mistretta, Rettore dell’Universitá di Cagliari. Prof.<br />
Robert Henry Riddell, Laurea honoris causa in Medicina a Chirurgia.Il presente diploma di laurea viene rilasciato a<br />
tutti gli effetti di legge. Dato in Calgiari, addi 1/12/1005, December, <strong>2005</strong>.<br />
The USCAP 95th <strong>Annual</strong> meeting. The Role of the Histopatholgist in Detection of Adult Hereditary Carcinoma,<br />
Colgan TJ, O’Malley FP, Riddell RH, Atlanta, Georgia, February <strong>2006</strong><br />
IOIBD (International Organization for the Study of inflammatory Bowel Disease). <strong>Pathology</strong> of indeterminant<br />
colitis, Bakubung, South Africa, March <strong>2006</strong>.<br />
American Society for Clinical <strong>Pathology</strong>, Surgical <strong>Pathology</strong> of the GI Tract, <strong>Pathology</strong> of Inflammatory Bowel<br />
Disease, Unknown <strong>and</strong> problem cases, South Carolina, April <strong>2006</strong>.<br />
Digestive Disease Week. Poster Session: Targeted Esophageal Biopsies: What you see is what you get.<br />
(WYSIWY`G) – Or Not? Post-Grad Course: Dysplasia in Barrett’s Esophagus. Can we do better? Los Angeles,<br />
California, May <strong>2006</strong>.<br />
RS, S<strong>and</strong>ler RS, Bolognese J, Quan H, Oxenius B, Joseph R, Horgan K, Riddell R, Morton D, Lana A, Baron J. A<br />
R<strong>and</strong>omized Trial of Rofecoxib to prevent colorectal adenomas: the approve trial. Gastroenterology, April <strong>2005</strong> Vol.<br />
128, No. 4, Suppl 2,<br />
Pg. A-34 No:200.<br />
Johnson P, MacNeill N, Baladjay L, Cohen Z, Riddell R, Steinhart H, McLeod R. Early Post-Operative Pouch histology<br />
predicts future chronic pouchitis after ileal Pouch-anal anastomosis for ulcerative colitis. Gastroenterology,<br />
April <strong>2005</strong>, Vol. 128, No.4., Suppl 2. Pg. A-114, No: 734.
Lanas A, Bresalier R, S<strong>and</strong>ler R, Bolognese J, Quan H, Oxenius B, Horgan K, Riddell R, Morton D, Baron J. Upper<br />
gastrointestinal events associated with rofecoxib in a colorectal adenoma. Chemoprevention trial. Gastroenterology<br />
<strong>2005</strong> Jul;129(1):371.<br />
Padol IT, Sagar M, Riddell RH, Hunt RH. Long term Helicobacter pylori infection of<br />
outbred North American Mongolian gerbils in conjunction with high salt diet does not<br />
result in gastric cancer – revisiting the model. Helicobacter, Vol.10, Issue 5, Pg 505, Abstract #07.02.<br />
Riddell RH, Mann V, Moayyedi P, Veldhuyzen S, Jankowski J, Bardette M, Louw J, Noad G, White RJ, Armstrong D.<br />
Targeted Esophageal Biopsies: What you see is what you get (WYSIWYG). Gastroenterology <strong>2006</strong>, Vol 130. Suppl<br />
2. A-161. Abstract<br />
Chen Shawn C, Mouchli A, Chadalawada V, Riddell R, Goldblum J, O’Brien M,<br />
Cummings O.W., Ulbright T. M., Rex D.K. Histopathology of small polyps removed in the videoendoscopic era.<br />
Gastrointestinal Endoscopy <strong>2006</strong> , Vol 63:5. Abstract T1344.<br />
Dr. Patrick Shannon<br />
A Case of Proptosis. JH Oestreicher, MD; NK Pang, MD; D Howarth, MD; P Shannon, MD. Canadian Ophthalmic<br />
<strong>Pathology</strong> Society, <strong>2006</strong>.<br />
Imaging of white matter abnormalities in cortical malformations using diffusion tensor imaging E Widjaja, S Blaser P<br />
Shannon, C Raybaud Radiological Society of North America, <strong>2006</strong>.<br />
Immunohistochemical localization of kallikrein 6 in brain tumors K Oikonomopoulou,<br />
P Shannon, E Diam<strong>and</strong>is AACR <strong>Annual</strong> Washington, DC, <strong>2006</strong>.<br />
Spectrum of CNS <strong>Pathology</strong> with Fetal Ventriculomegaly Evaluated by MRI Mann, E. H.Blaser, S.Pantazi, S. Shannon,<br />
P. Chitayat, D. Toi, A. Ryan, G. •Raybaud, C., <strong>2006</strong>.<br />
Spinal Cord Lesions In Intrauterine Asphyxia P Shannon, W Halliday, S Viero, S Keating. Society for Pediatric<br />
<strong>Pathology</strong>, Atlanta, <strong>2006</strong>.<br />
Histologic variation in cortical ependymomas. M Boulton M Bernstein P Shannon Canadian Association of<br />
Neuropathologists, St John’s, Newfoundl<strong>and</strong>, <strong>2006</strong>.<br />
Dr. Theo van der Kwast<br />
<strong>Pathology</strong> Update <strong>2005</strong>, Toronto. “Avoiding the false positive <strong>and</strong> negative prostate needle biopsy”, <strong>2005</strong>.<br />
European Society of <strong>Pathology</strong>, Short Course: Prognostic Factors in Uropathology: Prognostic factors <strong>and</strong> reporting<br />
of prostate carcinoma in radical prostatectomy specimens, invited lecture.<br />
Jahrestagung Basel, November <strong>2005</strong>. “Lessons from the european psa screening study erspc for the pathologist”.<br />
Workshop: Over diagnosis of cancer, Florence, November <strong>2005</strong>. “<strong>Pathology</strong> of prostate cancer: evidence for more<br />
<strong>and</strong> less aggressive lesions”.<br />
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47
Dr. S<strong>and</strong>ra Viero<br />
Kingdom J, Chaddha V, Alkazaleh F, Keating S, Viero S, Windrim R. From morphology to clinics: imaging placental<br />
insufficiency. Plenary lecture. European Placenta Group Meeting, Glasgow, Scotl<strong>and</strong>, (abstracted in Placenta 26(8-<br />
9)A6:L19), September <strong>2005</strong>.<br />
Whittle WL, Viero S, Kingdom J. Needle-wire targeted correlation of placental ultrasound findings with pathological<br />
lesions <strong>and</strong> obstetrical outcome. New investigators oral presentation. European Placenta Group Meeting, Glasgow,<br />
Scotl<strong>and</strong>, (abstracted in Placenta 26(8-9)A10:O11, <strong>2005</strong>), September <strong>2005</strong>.<br />
Hawkins C <strong>and</strong> Viero S. Lissencephaly with cerebellar hypoplasia: A new subtype? Podium presentation, Canadian<br />
Association of Neuropathology Meeting St. John’s, Newfoundl<strong>and</strong>, (abstracted in Can J Neurol Sci; 32: 555, <strong>2005</strong>),<br />
September <strong>2005</strong>.<br />
Viero S, Whittle WL, Shin V, Keating S, Kingdom J. <strong>Pathology</strong> of echogenic cystic lesions of the placenta: A<br />
study utilizing postdelivery sonographically guided needle localization. Poster presentation, Society for Pediatric<br />
<strong>Pathology</strong>, Atlanta, Georgia, February <strong>2006</strong>.<br />
Shannon P, Halliday W, Viero S, Keating S. Spinal cord lesions in intrauterine asphyxia.<br />
Podium presentation, Society for Pediatric <strong>Pathology</strong>, Atlanta, Georgia, February <strong>2006</strong>.<br />
Dr. Reinhold Vieth<br />
13th Vitamin D Workshop, Victoria, British Columbia, Canada. Invited Speaker, plus coauthor on two abstracts<br />
promoted to oral sessions. April 7 to 12, <strong>2006</strong>.<br />
13th Vitamin D Workshop, Victoria, British Columbia, Canada. Member of organizing committee. April 7 <strong>2006</strong>.<br />
House of Commons, London Engl<strong>and</strong>, Meeting on Sunlight, Vitamin D <strong>and</strong> Health; organized by Health Research<br />
Forum, <strong>and</strong> sponsored by Ian Gibson MP, in the Atlee Room, Portcullis House, November <strong>2005</strong>.<br />
International Workshop on UV Exposure Guidance, Munich, Germany, Joint meeting with WHO <strong>and</strong> Euroskin,: Sunprotection<br />
guidelines, implications with vitamin D. October <strong>2005</strong>.<br />
Direct-MS. Invited speaker: The biology of vitamin D, <strong>and</strong> its implications for the health of Canadians. Calgary<br />
Alberta. Two presentations. October <strong>2005</strong>. Council for Responsible Nutrition. <strong>Annual</strong> meeting, Palm Springs<br />
CA, USA. Invited speaker, “Calcium, Vitamin D <strong>and</strong> Health”. September <strong>2005</strong>.<br />
Italian Endocrine Society. The endocrinology <strong>and</strong> nutrition of vitamin D. Invited speaker, Lecture for continuing<br />
education. Rome, Italy, July <strong>2005</strong>.<br />
British Columbia Dietitians <strong>and</strong> Health Professionals, June 26, <strong>2006</strong>. Vancouver BC<br />
Canadian Cancer Society: North American Conference on UV, Vitamin D <strong>and</strong> Health. Metropolitan Hotel, Toronto,<br />
March <strong>2006</strong>,<br />
Direct-MS, Calgary. Presentation to health professionals in Calgary, Alberta. October <strong>2005</strong>. Prospects For Vitamin<br />
D Nutrition For Disease Prevention And Treatment.
Direct-MS, Calgary. Health information presentation to the general public. An advertised lecture, in Calgary,<br />
Alberta. October <strong>2005</strong>. Health Prospects For Vitamin D Nutrition. Recorded <strong>and</strong> available as a Webcast<br />
http://www.direct-ms.org/presentations.html<br />
Quebec Society of Medical Biochemists. Mont Saint Hiliard, Quebec, October <strong>2005</strong>.<br />
Gr<strong>and</strong> Rounds, St Joseph’s Hospital Toronto, “Vitamin D, Victorian vitamine or orphan drug”April <strong>2006</strong>.<br />
Gr<strong>and</strong> Rounds, North York General Hospital, “Vitamin D, Victorian vitamine or orphan drug”April <strong>2006</strong>.<br />
Scarborough Osteoporosis Support Group. Vitamin D <strong>and</strong> osteoporosis. Invited Lecture to the public, Scarborough<br />
Village Recreation Center, April <strong>2006</strong>.<br />
Dr. Elizabeth Winsor<br />
Kolomietz EK, Winsor EJT, Ryan G, Seaward G, Keating S, Wang C, Chitayat D. Prenatal diagnosis of acute<br />
promyelocytic leukemia in a fetus at 28 weeks’ gestation. Poster, Amer Soc Hum Genetics, October <strong>2005</strong>.<br />
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49
SCIENTIFIC PAPERS July 1, <strong>2005</strong> – June 30, <strong>2006</strong><br />
Dr. Irene Andrulis<br />
Sauer, M. <strong>and</strong> Andrulis, I.L. Identification <strong>and</strong> characterization of missense alterations in the BRCA1-associated<br />
RING domain (BARD1) gene in breast <strong>and</strong> ovarian cancers. J of Med Genet. 42: 633-638, <strong>2005</strong>.<br />
He, W., Bull, S.B., Gokgoz, N., Andrulis, I.L, <strong>and</strong> Wunder, J. Application of reliability coefficients in cDNA microarray<br />
data analysis. Statist. Med. 25:1051-1066, <strong>2006</strong>.<br />
Knight, J.A., John, E.M., Milne, R.L., Dite, G.S., Balbuena, R., Shi, E.J.Q., Giles, G.G., Ziogas, A., Andrulis, I.L.,<br />
Whittemore, A.S., Hopper, J.L. for the Breast Cancer Family Registry. An inverse association between ovarian cysts<br />
<strong>and</strong> breast cancer. Int J Cancer 118: 197-202, <strong>2006</strong>.<br />
Tiet, T.D., Hopyan, S., Nadesan, P., Gokgoz, N., Poon, R., Andrulis, I.L., Alman, B.A., <strong>and</strong> Wunder, J.S. Constitutive<br />
hedgehog signalling in chondrosarcoma upregulates tumor cell proliferation. Amer. J. Pathol. 168:321-330, <strong>2006</strong>.<br />
Spurdle, A.B., Antoniou, A.C., Kelemen, L., Holl<strong>and</strong> H., Peock, S., Cook, M.R., Smith, P.L. Greene,M.H., Simard, J.,<br />
Plourde, M., Southey, M., Godwin, A., Beck, J., Miron, A., Daly, M., Santella, R., Hopper, J., John, E.M., Andrulis,<br />
I.L., Durocher, F., Struewing, J.P., ABCFS, AJBCS, BCFR, INHERIT, kConFaB, EMBRACE Study Collaborators, Easton,<br />
D.F., <strong>and</strong> Chenevix-Trench, G. The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 <strong>and</strong><br />
BRCA2 mutation carriers. Cancer Epidemiol, Biomarkers <strong>and</strong> Prev.15:76-79, <strong>2006</strong>.<br />
Bernstein, J.L., Teraoka, S.N., John, E.M., Andrulis, I.L., Knight, J., Lapinski, R., Olson, E.R., Wolitzer, A.L., Seminara.<br />
D., Whittemore, A.S., <strong>and</strong> Concannon, P. The CHEK2*1100delC germline mutation <strong>and</strong> risk of breast cancer.<br />
Cancer Epidemiol, Biomarkers <strong>and</strong> Prev. 15:348-352, <strong>2006</strong>.<br />
To, M.D., Gokgoz, N., Doyle, T.G., Donoviel, D., Knight, J.A., St. George Hyslop, P., Bernstein, A. <strong>and</strong> Andrulis, I.L.<br />
Functional Characterization of Novel Presenilin-2 Variants Identified in Human Breast Cancers. Oncogene 25:3557-<br />
3564, <strong>2006</strong>.<br />
Smith, P., McGuffog, L., Easton, D.F., Mann, G.J., Pupo, G.M., Newman, B., Chenevix-Trench, G., kConFab<br />
Szabo, C., Southey, M., Renard, H., Odefrey, F., Lynch, H., Stoppa-Lyonnet, D., Couch, F., Hopper, J.L., Buys, S.,<br />
Andrulis, I.L., Senie, R., Breast Cancer Family Registry, BRCAX Collaborators group, Goldgar, D.E., Oldenburg, R.,<br />
Kroeze-Jansema, K., Kraan, J., Meijers-Heijboer, H., Klijn, J.G.M., van Asperen, C., van Leeuwen, I., Vasen, H.F.A.,<br />
Cornelisse, C.J., Devilee, P., Baskcomb, L., Seal, S., Barfoot, R., Mangion, J., Hall, A., Edkins, S., Rapley, E., Wooster,<br />
R., Chang-Claude, J., Eccles, D., Evans, D.G., Futreal, P.A., Nathanson, K.L., Weber, B.L., Breast Cancer<br />
Susceptibility Collaboration (UK), Rahman, N., Stratton, M.R. A genome wide linkage search for breast cancer<br />
susceptibility genes. Genes, Chromosomes <strong>and</strong> Cancer 45: 646-655, <strong>2006</strong>.<br />
Pritchard K.I., Shepherd L.E., O’Malley F.P., Andrulis I.L., Tu D., <strong>and</strong> Levine M.N. for the National Cancer Institute<br />
of Canada Clinical Trials Group. Neu/ErbB2 <strong>and</strong> responsiveness of breast cancer to adjuvant chemotherapy. New<br />
Engl<strong>and</strong> Journal of <strong>Medicine</strong> 354:2103-2111, <strong>2006</strong>.
Barsyte-Lovejoy, D., Lau, S.K., Boutros, P.C., Khosravi, F., Jurisica, I., Andrulis, I.L., Tsao, M.S., <strong>and</strong> Penn, L.Z. The<br />
c-Myc oncogene directly induces H19 non-coding RNA by allele specific binding to potentiate tumorigenesis. Cancer<br />
Research 66:5330-5337, <strong>2006</strong>.<br />
Onay, V.U., Briollais, L., Knight, J.A., Shi, E., Wang, Y., Wells, S., Li, H., Rajendram, I., Andrulis, I.L., <strong>and</strong> Ozcelik, H.<br />
SNP-SNP Interactions in Breast Cancer Susceptibility. BMC Cancer. 6:114, <strong>2006</strong>.<br />
Dr. Azar Azad<br />
Cohn TA, Remington G, Zipursky RB, Azad A, Connolly P, Wolever TMS; Insulin Resistance <strong>and</strong> Adiponectin levels in<br />
drug-free patients with Schizophrenia: A preliminary <strong>Report</strong>. Can J Psychiatry, Vol 51, No 6, May <strong>2006</strong>.<br />
Knight JA, Thompson S, Raboud JM, Hoffman BR, Azad A. Light <strong>and</strong> exercise <strong>and</strong> melatonin production in women.<br />
Oral presentation, Society for Epidemiologic Research <strong>and</strong> Canadian Society for Epidemiology <strong>and</strong> Biostatistics,<br />
Toronto , Canada, American Journal of Epidemiology 161 (11 Suppl):S146, <strong>2005</strong>, June <strong>2005</strong>.<br />
Dr. Bharati Bapat<br />
Charames, G. <strong>and</strong> Bapat B. Cyclooxygenase-2 knockdown by RNA interference in colon cancer. Int J Oncol 28(2):<br />
543-549, <strong>2006</strong>.<br />
Woods MO, Hyde AL, Curtis FK, Stuckless S, Green J, Pollett A, Robb JD, Green R, Croitoru M, Careen A, Chaulk<br />
JAW, Jegathesan J, McLaughlin J, Gallinger S, Younghusb<strong>and</strong> B, Bapat B, Parfrey PS. High frequency of hereditary<br />
colorectal cancer in Newfoundl<strong>and</strong> likely involved novel susceptibility genes. Clin Cancer Res 11(19): 6853-6861,<br />
<strong>2005</strong>.<br />
Lindor NM, Rabe K, Petersen G, Haile R, Casey G, Baron J, Gallinger S, Bapat B, Aronson M, Hopper J, Jass J,<br />
LeMarch<strong>and</strong> L, Grove J, Potter J, Newcomb P, Terdiman JP, Conrad P, Moslein G, Goldberg R, Ziogas A, Anton-Culver<br />
H, de Andrade M, Siegmund K, Thibodeau SN, Boardman LA, Seminara D. Lower cancer risks in Amsterdam-I<br />
criteria families without mismatch repair deficiency. Journal of American Medical Association (JAMA) 293: 1986-<br />
1994, <strong>2005</strong><br />
Durno, C.A., Aronson, M., Bapat, B., Cohen, Z., Gallinger. S. Family history <strong>and</strong> molecular features of children,<br />
adolescents <strong>and</strong> young adults with colorectal carcinoma. Gut 54: 1146-1150, <strong>2005</strong>.<br />
Casey,G., Lindor, NM., Papadopoulos, N., Thibodeau, SN., Moskow, J., Steelman, S., Buzin, CH., Sommer SS.,<br />
Collins, CE., Butz, M. Aronson, M., Gallinger, S., Barker MA., Young, JP., Jass, JR., Hopper JL., Diep, A., Bapat, B.,<br />
Salem, M., Seminara, D. Haile, R. Colon Cancer Family Registry. Conversion analysis for mutation detection in MLH1<br />
<strong>and</strong> MSH2 patients with colorectal cancer. JAMA 293: 799-809, <strong>2005</strong>.<br />
Chetty, R., Salahshor, S. Bapat, B., Berk, T., Croitoru, M., Gallinger S. Intraductal papillary mucinous neoplasm of<br />
pancreas in a patient with attenuated familial adenomatous polyposis. J Clin Path 58: 97-101, <strong>2005</strong>.<br />
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Dr. Terry Colgan<br />
Snyder TM, Renshaw AA, Styer PE, Mody DR, Colgan TJ. Altered recognition of reparative changes in ThinPrep®<br />
specimens in the College of American Pathologists Gynecologic Cytology Program. Arch Pathol Lab Med., 129:861-65,<br />
<strong>2005</strong>.<br />
Renshaw A, Mody DR, Wang E, Wilbur D, Colgan TJ. Measuring the significance of participant evaluation of<br />
acceptability of cases in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal<br />
Cytology. Arch Pathol Lab Med 129:1093-1096, <strong>2005</strong>.<br />
Guo J, Colgan TJ, DeSouza L, Rodrigues MJ, Romaschin AD, Siu KWM. Direct analysis of laser capture microdissected<br />
endometrial carcinoma <strong>and</strong> epithelium by MALDI mass spectrometry. Rapid Communications in Mass Spectrometry 19:<br />
2762-2766, <strong>2005</strong>.<br />
Colgan TJ: Disclosure of diagnostic errors: the death knell of retrospective pathology reviews? J. Lower Genital Tract<br />
Disease 9: 216 – 8, <strong>2005</strong>.<br />
Renshaw A, Mody D, Wilbur D, Davey D, Colgan TJ. Letter-to-the Editor (Reply). Arch Pathol Lab Med. 130: 144 – 145,<br />
<strong>2006</strong>.<br />
Finch A, Shaw P, Rosen B, Murphy J, Narod SA, Colgan TJ. Clinical <strong>and</strong> pathologic findings of prophylactic salpingooophorectomies<br />
in 159 BRCA1 <strong>and</strong> BRCA2 carriers. Gynecol Oncol. 100: 58 – 64, <strong>2006</strong>.<br />
Milic A, Asch MR, Hawrylyshyn PA, Allen LM, Colgan TJ, Kachura JR, Hayeems EB. Laparoscopic ultrasound guided<br />
radiofrequency ablation of uterine fibroids. Cardiovascular <strong>and</strong> Interventional Rad J. <strong>2006</strong>.<br />
Renshaw A, Mody D, Wang E, Haja J, Colgan TJ. Hyperchromatic Crowded Groups in Cervical Cytology: Differing<br />
Appearances <strong>and</strong> Interpretations in Conventional <strong>and</strong> ThinPrep Preparations – A study from the College of American<br />
Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology. Arch Pathol Lab Med. <strong>2006</strong> Mar;130:332-<br />
6.<br />
Renshaw A, Mody D, Styer P, Schwartz M, Ducatman B, Colgan TJ. Pap Tests with Mixed High <strong>and</strong> Low Grade<br />
Squamous Intraepithelial Lesion Features: Distinct Performance in the College of American Pathologists Interlaboratory<br />
Comparison Programme in Cervicovaginal Cytopathology. Arch Pathol Lab Med. <strong>2006</strong> Apr. 130: 456-9.<br />
Dr. Greg Denomme<br />
Denomme GA, Reid ME. Inaugural meeting of the consortium for blood group genes (CBGG): a summary report.<br />
Immunohematology 21:129-131, <strong>2005</strong>.<br />
Denomme GA, Wagner FF, Fern<strong>and</strong>es BJ, Li W, Flegel WA. Partial D, weak D types, <strong>and</strong> novel RHD alleles among<br />
33,864 multi-ethnic prospective transfusion recipients: implications for anti-D alloimmunization <strong>and</strong> prevention.<br />
Transfusion 45:1554-1560, <strong>2005</strong>.
Dr. Eleftherios Diam<strong>and</strong>is<br />
Michael IP, Sotiropoulou G, Pampalakis G, Magklara A, Ghosh M, Wasney G, Diam<strong>and</strong>is EP. Biochemical <strong>and</strong><br />
enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer<br />
progression. J Biol Chem <strong>2005</strong>;280:14628-14635.<br />
Komatsu N, Saijoh K, Toyama T, Ohka R, Otsuki N, Hussack G, Takehara H, Diam<strong>and</strong>is EP. Multiple tissue kallikrein<br />
mRNA <strong>and</strong> protein expression in normal skin <strong>and</strong> skin diseases. Br J Dermatol <strong>2005</strong>;153:274-281.<br />
Stephan C, Jung K, Soosaipillai A, Yousef GM, Cammann H, Meyer H, Xu C, Diam<strong>and</strong>is EP. Clinical utility of human<br />
gl<strong>and</strong>ular kallikrein 2 within a neural network for prostate cancer detection. BJU Int <strong>2005</strong>;96:521-527.<br />
Yousef GM, White NMA, Michael IP, Cho JC, Robb JD, Kurlender L, Khan S, Diam<strong>and</strong>is EP. Identification of new<br />
splice variants <strong>and</strong> differential expression of the human kallikrein 10 gene, a c<strong>and</strong>idate cancer biomarker. Tumour<br />
Biol <strong>2005</strong>;26:227-235.<br />
Obiezu CV, Shan SJ, Soosaipilla A, Luo LY, Grass L, Sotiropoulou G, Petraki CD, Papanastasiou PA, Levesque MA,<br />
Diam<strong>and</strong>is EP. Human kallikrein 4: quantitative study in tissues <strong>and</strong> evidence for its secretion into biological fluids.<br />
Clin Chem <strong>2005</strong>;51:1432-1442. Rosen DG, Wang L, Atkinson JN, Yu Y, Lu KH, Diam<strong>and</strong>is EP, Hellstrom I, Mok<br />
SC, Liu J, Bast RC Jr. Potential markers that complement expression of CA125 in epithelial ovarian cancer. Gynecol<br />
Oncol <strong>2005</strong>;99:267-277.<br />
Sidiropoulos M, Pampalakis G, Sotiropoulou G, Katsaros, D, Diam<strong>and</strong>is EP. Downregulation of human kallikrein 10<br />
(KLK10/NES1) by CpG isl<strong>and</strong> hypermethylation in breast, ovarian <strong>and</strong> prostate cancers. Tumour Biol <strong>2005</strong>;26:324-<br />
336.<br />
Yousef GM, Ejeckam GC, Best LM, Diam<strong>and</strong>is EP. Collecting duct carcinoma associated with oncocytoma: Int Braz J<br />
Urol <strong>2005</strong>;31:465-467.<br />
Komatsu N, Saijoh K, Sidiropoulos M, Tsai B, Levesque MA, Elliott MB, Takehara K, Diam<strong>and</strong>is EP. Quantification<br />
of human tissue kallikreins in the stratum corneum: dependence on age <strong>and</strong> gender. J Invest Dermatol<br />
<strong>2005</strong>;125:1182-1189.<br />
Petraki CD, Gregorakis AK, Vaslamatzis MM, Papanastasiou PA, Yousef GM, Levesque MA, Diam<strong>and</strong>is EP. Prognostic<br />
implications of the immunohistochemical expression of human kallikreins 5, 6, 10 <strong>and</strong> 11 in renal cell carcinoma.<br />
Tumour Biol <strong>2006</strong>;27:1-7.<br />
Brown DA, Stephan C, Ward RL, Law M, Hunter M, Bauskin AR, Amin J, Jung K, Diam<strong>and</strong>is EP, Hampton GM,<br />
Russell PJ, Giles GG, Breit SN. Measurement of serum levels of macrophage inhibitory cytokine 1 combined with<br />
prostate-specific antigen improves prostate cancer diagnosis. Clin Cancer Res <strong>2006</strong>;12:89-96.<br />
Simon I, Zhou S, Corral L, Diam<strong>and</strong>is EP, Sarno MJ, Wolfert RL, Kim NW. B7-H4 is a novel membrane-bound protein<br />
<strong>and</strong> a c<strong>and</strong>idate serum <strong>and</strong> tissue biomarker for ovarian cancer. Cancer Res <strong>2006</strong>;66:1570-1575.<br />
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Fritzsche F, Gansukh T, Borgono C, Burkhardt M, Pahl S, Mayordomo E, Winzer KJ, Weichert W, Denkert C, Jung<br />
K, Stephan C, Dietel M, Diam<strong>and</strong>is EP, Dahl E, Kristiansen G. Expression of human kallikrein 14 (KLK14) in breast<br />
cancer is associated with higher tumour grades <strong>and</strong> positive nodal status. Br J Cancer <strong>2006</strong>;94:540-547.<br />
Darling MR, Jackson-Boeters L, Daley TD, Diam<strong>and</strong>is EP. Human Kallikrein 6 expression in salivary gl<strong>and</strong> tumors. J<br />
Histochem Cytochem <strong>2006</strong>;54:337-342.<br />
Luo L-Y, Shan SJC, Elliott MB, Soosaipillai A, Diam<strong>and</strong>is EP. Purification <strong>and</strong> characterization of human kallikrein 11,<br />
a c<strong>and</strong>idate prostate <strong>and</strong> ovarian cancer biomarker, from seminal plasma. Clin Cancer Res <strong>2006</strong>;12:742-750.<br />
Slagter MH, Gooren LJ, de Ronde W, Soosaipillai A, Giltay EJ, Paliouras M, Diam<strong>and</strong>is EP. Serum <strong>and</strong> urine tissue<br />
kallikrein concentrations in male-to-female transsexuals treated with anti<strong>and</strong>rogens <strong>and</strong> estrogens. Clin Chem<br />
<strong>2006</strong>;52:1356-1365.<br />
Parr RL, Dakubo GD, Gr<strong>and</strong>all KA, Maki J, Reguly B, Aguirre A, Wittock R, Robinson K, Alex<strong>and</strong>er JS, Birch-Machin<br />
MA, Abdel-Malak M, Froberg MK, Diam<strong>and</strong>is EP, Thayer RE. Somatic mitochondrial DNA mutations in prostate<br />
cancer <strong>and</strong> normal appearing adjacent gl<strong>and</strong>s in comparison to age-matched prostate samples without malignant<br />
histology. J Mol Diagn <strong>2006</strong>;8:312-319.<br />
Prezas P, Arlt MJ, Viktorov P, Soosaipillai A, Holzscheiter L, Schmitt M, Talieri M, Diam<strong>and</strong>is EP, Kruger A, Magkolen<br />
V. Overexpression of human tissue kallikrein genes KLK4, 5, 6 <strong>and</strong> 7 increases the malignant phenotype of ovarian<br />
cancer cells. Biol Chem <strong>2006</strong>;387:807-811.<br />
Stephan C, Meyer HA, Cammann H, Nakamura T, Diam<strong>and</strong>is EP, Jung K. Improved prostate cancer detection with a<br />
human kallikrein 11 <strong>and</strong> percentage free PSA-based artificial neural network. Biol Chem <strong>2006</strong>;387:801-805.<br />
Pampalakis G, Diam<strong>and</strong>is EP, Sotiropoulou G. The epigenetic basis for the aberrant expression of kallikreins in<br />
human cancers. Biol Chem <strong>2006</strong>;387:795-799.<br />
Obiezu CV, Michael IP, Levesque MA, Diam<strong>and</strong>is EP. Human kallikrein 4: enzymatic activity, inhibition <strong>and</strong><br />
degradation of extracellular matrix proteins. Biol Chem <strong>2006</strong>;387:749-759.<br />
Memari N, Grass L, Nakamura T, Karakucuk I, Diam<strong>and</strong>is EP. Human kallikrein 9: Production of recombinant<br />
proteins <strong>and</strong> specific antibodies. Biol Chem <strong>2006</strong>;387:733-740.<br />
Kishi T, Cloutier SM, Kundig C, Deperthes D, Diam<strong>and</strong>is EP. Activation <strong>and</strong> enzymatic characterization of<br />
recombinant human kallikrein 8. Biol Chem <strong>2006</strong>;387:723-731.<br />
Felber LM, Kundig C, Borgono CA, Chagas JR, Tasinato A, Jichlinski P, Gygi CM, Leisinger H-J, Diam<strong>and</strong>is EP,<br />
Deperthes D, Cloutier SM. Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14. FEBS J<br />
<strong>2006</strong>;273:2505-2514.<br />
Santin AD, Diam<strong>and</strong>is EP, Bellone S, Marizzoni M, B<strong>and</strong>iera E, Palmieri M, Papasakelariou C, Katsaros D, Burnett<br />
A, Pecorelli S. Overexpression of kallikrein 10 (hK10) in uterine serous papillary carcinoma. Am J Obstet Gynecol<br />
<strong>2006</strong>;194:1296-1302.
Diam<strong>and</strong>is EP. Serum proteomic profiling by matrix-assisted laser desorption-ionization time-of-flight mass<br />
spectrometry for cancer diagnostics: next steps. Cancer Res <strong>2006</strong>;66:5540-5541.<br />
Stephan C, Jung K, Nakamura T, Yousef GM, Diam<strong>and</strong>is EP. Serum human gl<strong>and</strong>ular kallikrein 2 (hK2) for<br />
distinguishing stage <strong>and</strong> grade of prostate cancer. Int J Urol <strong>2006</strong>; 13:238-243.<br />
Oikonomopoulou K, Scorilas A, Michael IP, Grass L, Soosaipillai A, Rosen B, Murphy J, Diam<strong>and</strong>is EP. Kallikreins as<br />
markers of disseminated tumour cells in ovarian cancer – a pilot study. Tumour Biol <strong>2006</strong>;27:104-114.<br />
Borgo�o CA, Kishi T, Scorilas A, Harbeck N, Dorn J, Schmalfeldt B, Schmitt M, Diam<strong>and</strong>is EP. Human kallikrein 8<br />
protein is a favorable prognostic marker in ovarian cancer. Clin Cancer Res <strong>2006</strong>;12:1487-1493.<br />
Michael IP, Pampalakis G, Mikolajczyk SD, Malm J, Sotiropoulou G, Diam<strong>and</strong>is EP. Human tissue kallikrein 5 is a<br />
member of a proteolytic cascade pathway involved in seminal clot liquefaction <strong>and</strong> potentially in prostate cancer<br />
progression. J Biol Chem <strong>2006</strong>;281:12743-12750.<br />
Stephan C, Xu C, Brown DA, Breit SN, Michael A, Nakamura T, Diam<strong>and</strong>is EP, Meyer H, Cammann H, Jung K. Three<br />
new serum markers for prostate cancer detection within a percent free PSA-based artificial neural network. Prostate<br />
<strong>2006</strong>;66:651-659.<br />
Dr. Bernard Fern<strong>and</strong>es<br />
von Dadelszen P, Sermer M, Millier J, Allen LC, Fern<strong>and</strong>es BJ, Johnson JA, Shime J, Winsor EJ, Ryan G. A r<strong>and</strong>omized<br />
controlled trial of biopsy forceps <strong>and</strong> cannula aspiration for transcervical chorionic villus sampling. BJOG <strong>2005</strong><br />
may:112(5):559-566.<br />
Denomme GA, Wagner FF, Fern<strong>and</strong>es BJ, Li W, Flegel WA. Partial D, weak D types, <strong>and</strong> novel RHD alleles<br />
among 33,864 multiethnic patients: implications for anti-D alloimmunization <strong>and</strong> prevention. Transfusion <strong>2005</strong><br />
Oct:45(10):1554-1560.<br />
Dr. Steven Gallinger<br />
Chetty R, Salahshor S, Bapat B, Berk T, Croitoru M, Gallinger S. Intraductal papillary mucinous neoplasm of<br />
pancreas in a patient with attenuated familial adenomatous polyposis. J Clin Path <strong>2005</strong>: 58 pp 97-101.<br />
Dixon E, Vollmer CM, Sahajpal A, Cattral M, Grant D, Doig C, Hemming A, Taylor B, Langer B, Greig P, Gallinger S.<br />
A 12 year cohort study at a North American Center: adoption of an aggressive surgical approach leads to improved<br />
survival in patients with gallbladder cancer. Annals of Surgical Oncology <strong>2005</strong>: 241(3) pp 385-394<br />
Casey G, Lindor NM, Papadopoulos N, Thibodeau SN, Moskow J, Steelman S, Buzin CH, Sommer SS, Collins CE,<br />
Butz M, Aronson M, Gallinger S, Barker MA, Young JP, Jass JR, Hopper JL, Diep A, Bapat B, Salem M, Seminara D,<br />
Haile R, Colon Cancer Family Registry. Conversion analysis for mutation detection in MLH1 <strong>and</strong> MSH2 patients with<br />
colorectal cancer. JAMA <strong>2005</strong>: 293(7): pp 799-809.<br />
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55
Jaskolka JD, Asch MR, Kachura JR, Ho CS, Ossip M, Wong F, Sherman M, Grant DR, Greig PD, Gallinger S. Needle<br />
tract seeding after radiofrequency ablation of hepatic tumors. J Vasc Interv Radiol <strong>2005</strong>: 16(4): pp 485-491.<br />
Dixon E, Jr CM, Sahajpal A, Cattral MS, Grant DR, Taylor BR, Langer B, Gallinger S, Greig PD. Transduodenal<br />
resection of peri-ampullary lesions. World J Surg <strong>2005</strong>: 29: pp 649-652.<br />
Durno CA, Aronson M, Bapat B, Cohen Z, Gallinger S. Family history <strong>and</strong> molecular features of children,<br />
adolescents <strong>and</strong> young adults with colorectal carcinoma. Gut <strong>2005</strong>:54: pp 1146-1150.<br />
Lindor NM, Rabe K, Petersen G, Haile R, Casey G, Baron J, Gallinger S, Bapat B, Aronson M, Hopper J, Jass J,<br />
LeMarch<strong>and</strong> L, Grove J, Potter J, Newcomb P, Terdimann J, Conrad P, Moslein G, Ziogas A, Anton-Culver H,<br />
Goldberg R, Thibodeau SN, Boardman L, Seminara D. Lower cancer risks in Amsterdam-I criteria families without<br />
mismatch repair deficiency. JAMA <strong>2005</strong>: 293(16): pp 1979-1985.<br />
Gryfe R, Gallinger S. Germline PMS2 mutations: one hit or two? Gastroenterology <strong>2005</strong>: 128(5): pp 1506-1509.<br />
Kim R, Sakamoto S, Haider M, Molinari M, Gallinger S, McGilvray I, Greig P, Grant D, Cattral MS. Role of magnetic<br />
resonance imaging in assessing biliary anatomy in right lobe living donors. Transpl <strong>2005</strong>: 79(10): pp 1417-1421.<br />
Ramji F, Cotterchio M, Manno M, Rabeneck L, Gallinger S. Association between subject factors <strong>and</strong> colorectal<br />
cancer screening participation in Ontario Canada. Cancer Detection <strong>and</strong> Prevention <strong>2005</strong>: 29: pp 221-226.<br />
Batlle E, Bacani J, Begthel H, Jonkeer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T,<br />
Gallinger S, Pals S, Clevers H. EphB activity suppresses colorectal cancer progression. Nature <strong>2005</strong>: 435(7045): pp<br />
1126-1130.<br />
Salahshor S, Goncalves J, Chetty R, Gallinger S, Woodgett JR. Differential gene expression profile reveals<br />
deregulation of pregnancy specific beta-1 glycoprotein 9 early during colorectal carcinogenesis. BMC Cancer <strong>2005</strong>:<br />
5(1) pp 66.<br />
Suriano G, Yew S, Ferreira P, Senz J, Kaurah P, Ford JM, Longacre TA, Norton JA, Chun N, Young S, Oliveira MJ,<br />
MacGillivray B, Rao A, Sears D, Jackson CE, Boyd F, Yee C, Deters C, Pai GS, Hammond LS, McGivern BJ, Medgyesy<br />
D, Sartz D, Arun B, Oelschlager BK, Upton MP, Neufeld-Kaiser W, Silva OE, Donenberg TR, Kooby DA, Sharma S,<br />
Jonsson B-A, Gronberg H, Gallinger S, Seruca R, Lynch H, Huntsman DG. Characterization of a recurrent germ line<br />
mutation of the E-cadherin gene: implications for genetic testing <strong>and</strong> clinical management. Human Cancer Biology<br />
<strong>2005</strong>: 11(15) pp 5401-5409.<br />
Cotterchio M, Manno M, Klar N, McLaughlin J, Gallinger S. Colorectal screening is associated with reduced<br />
colorectal cancer risk: a case-control study within the population-based Ontario Familial Colorectal Cancer Registry.<br />
Cancer Causes <strong>and</strong> Control <strong>2005</strong>: 16(7): pp 865-875.<br />
Woods MO, Hyde AL, Curtis FK, Stuckless S, Green J, Pollett A, Robb JD, Green R, Croitoru M, Careen A, Chaulk<br />
JAW, Jegathesan J, McLaughlin J, Gallinger S, Younghusb<strong>and</strong> B, Bapat B, Parfrey PS. High frequency of hereditary<br />
colorectal cancer in Newfoundl<strong>and</strong> likely involved novel susceptibility genes. Clin Cancer Res <strong>2005</strong>: 11(19): pp<br />
6853-6861.
Bacani J, Zwingerman R, Di Nicola N, Spencer S, Wegrynowski T, Mitchell K, Hay K, Redston M, Holowaty E,<br />
Huntsman D, Pollett A, Riddell R, Gallinger S. Tumor microsatellite instability in early onset gastric cancer. J Mol<br />
Diagn <strong>2005</strong>: 7(4): pp 465-477.<br />
Fazio L., Cotterchio M, Manno M, Mclaughlin J, Gallinger S. Association between colonic screening, subject<br />
characteristics, <strong>and</strong> stage of colorectal cancer. Am J Gastroenterol <strong>2005</strong>: 100(11): pp 2531-2539.<br />
Hitchins M, Williams R, Cheon K, Halani N, Ap-Lin V, Packham D, Ku S, Buckle A, Hawkins N, Burn J, Gallinger<br />
S, Goldblatt J, Kirk J, Tomlinson I, Scott R, Spigelman A, Suter C, Martin D, Suthers G, Ward, R. MLH1 germline<br />
epimutations as a factor in hereditary non-polyposis colorectal cancer. Gastroenterology <strong>2005</strong>: 129(5): pp 1392-<br />
1399.<br />
Mackay HJ, Billingsley K, Gallinger S, Berry S, Smith A, Yeung R, Pond GR, Croitoru M, Swanson PE, Krishnamurthi<br />
S, Siu LL. A multicenter phase II study of “Adjuvant” irinotecan following resection of colorectal hepatic metastases.<br />
Am J Clin Oncol <strong>2005</strong>:28(6) pp 547-554.<br />
Johnson PM, Gallinger S, Mcleod RS. Surveillance colonoscopy in individuals at risk for hereditary nonpolyposis<br />
colorectal cancer: an evidence-based review. Dis Colon Rectum <strong>2006</strong>: 49(1): pp 80-93.<br />
Kim RD, Kundal PS, McGilvray ID, Cattral MS, Taylor B, Langer B, Grant DR, Zogopoulos G, Shah SA, Greig PD,<br />
Gallinger S. Predictors of failure following pancreaticoduodenectomy for ampullary carcinoma. J Am Coll Surg<br />
<strong>2006</strong>: 202(1) pp 112-119.<br />
Shah SA, Greig PD, Gallinger S, Cattral MS, Dixon E, Kim RD, Taylor BR, Grant DR, Vollmer CM. Factors associated<br />
with early recurrence after resection for hepatocellular carcinoma <strong>and</strong> outcomes. J Am Coll Surg <strong>2006</strong>: 202(2) pp<br />
275-283.<br />
Wei AC, Greig PD, Grant D, Taylor B, Langer B, Gallinger S. Survival after hepatic resection for colorectal<br />
metastases: a 10-year experience. Ann Surg Oncol <strong>2006</strong>: 13(5) pp 668-676.<br />
Jenkins M, Croitoru ME, Monga N, Cleary S, Cotterchio M, Hopper J, Gallinger S. Risk of colorectal cancer in<br />
monoallelic <strong>and</strong> biallelic carriers of MYH mutations: a population-based case-family study. Cancer Epidemiol<br />
Biomarkers Prev <strong>2006</strong>: 15(2) pp 312-314.<br />
Shah SA, Haddad R, Al-Sukhni W, Kim RD, Greig PD, Grant DR, Taylor BR, Langer B, Gallinger S, Wei AC. Surgical<br />
resection of hepatic <strong>and</strong> pulmonary metastases from colorectal carcinoma. J Am Coll Surg <strong>2006</strong>: 202(3) pp 468-<br />
475.<br />
Petersen GM, de Andrade M, Goggins M, Hruban RH, Bondy M, Korczak JF, Gallinger S, Lynch HT, Syngal S, Rabe<br />
KG, Seminara D, Klein AP. Pancreatic cancer genetic epidemiology consortium. Cancer Epidemiol Biomarkers Prev<br />
<strong>2006</strong>: 15(4) pp 704-710.<br />
Durno CA, Gallinger S. Genetic Predisposition to Colorectal Cancer: New Pieces in the Pediatric Puzzle. J Pediatr<br />
Gastroenterol Nutr. <strong>2006</strong>: 43(1) pp 5-15.<br />
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Bacani JT, Soares M, Zwingerman R, Di Nicola N, Senz J, Riddell R, Huntsman D, Gallinger S. CDH1/E-cadherin<br />
germline mutations in early onset gastric cancer. J Med Genet. June <strong>2006</strong> Epub.<br />
Fishman PN, Pond GR, Moore MJ, Oza A, Burkes RL, Siu LL, Feld R, Gallinger S, Greig P, Knox JJ. Natural history<br />
<strong>and</strong> chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113<br />
cases. Am J Clin Oncol. <strong>2006</strong>: 29(3) pp 225-31.<br />
Dr. Marc Grynpas<br />
Vieira, APGF; Hancock, R; Dumitriu, Schwartz, M; Limeback, H <strong>and</strong> Grynpas MD<br />
How does Fluoride affect dentin microhardness <strong>and</strong> mineralization? J Dent Res<br />
Oct 84(10): 951-7, <strong>2005</strong>.<br />
Veira, APGF, Mousny, M, Maia, R, Hancock, R, Everett, ET, Grynpas, MD. Assessment of teeth as biomarkers for<br />
skeletal Fluoride exposure. Osteoporosis Int. Dec;16(12): 1576-82, <strong>2005</strong>.<br />
Banse X, Devogelaer JP, Holmyard D, Grynpas MD. Vertebral cancellous bone turn- over: microcallus <strong>and</strong> bridges in<br />
backscatter electron microscopy. Micron, 36(7-8): 710-4, <strong>2005</strong>.<br />
Vieira, APGF; Hancock, R; Dumitriu, M; Limeback, H <strong>and</strong> Grynpas, MD. Fluoride’s effect on human dentin<br />
ultrasound velocity (elastic modulus) <strong>and</strong> tubule size. Euro J Oral Science. Feb; 114(1): 83-8, <strong>2005</strong>.<br />
Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JEI, Gong<br />
XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GIL,<br />
Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai B, Bruneau BG, Grynpas MD, Henderson<br />
JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. A Gja1<br />
missense mutation in a mouse model of Oculodentodigital Dysplasia (ODDD). Development. Oct; 132(19): 4375-<br />
86, <strong>2005</strong>.<br />
Wise LM, Waldman SD, Kasra M, Cheung R, Binnington, K<strong>and</strong>el RA, White LM, Grynpas MD. Effect of zoledronate<br />
on bone quality in the treatment of aseptic loosening of hip arthroplasty in the dog. Calcif Tissue Int. 77(6): 367-<br />
75, December <strong>2005</strong>.<br />
Facchini DM, Yuen VG, Battell ML, McNeill JH, Grynpas MD. The Effects of<br />
Vanadium Treatment on Bone in Diabetic <strong>and</strong> Non-Diabetic Rats. Bone, Vol 38,<br />
Issue 3, March, 368-377, <strong>2006</strong>.<br />
Waldman SD, Couto DC, Grynpas MD, Pilliar RM, K<strong>and</strong>el RA . A single application of cyclic loading can accelerate<br />
matrix deposition <strong>and</strong> enhance the properties of tissue-engineered cartilage. Osteoarthritis <strong>and</strong> Cartilage, Vol.14,<br />
323-330, <strong>2006</strong>.<br />
K<strong>and</strong>el RA, Grynpas MD, Pilliar RM, Lee J, Wang J, Waldman SD, Zalzal P, Hurtig MB Repair of osteochondral<br />
defects with biphasic cartilage-calcium Polyphosphate constructs in a sheep model. Biomaterials, Aug; 27(22):<br />
4120-31, <strong>2006</strong>.
Dr. Barry Hoffman<br />
Knight JA, Thompson S, Raboud JM, Hoffman BR. Light <strong>and</strong> exercise <strong>and</strong> melatonin production in women.<br />
American Journal of Epidemiology 162:1-9, <strong>2005</strong>.<br />
Dr. David Howarth<br />
Sivak-Callcott JA, Lim WK, Seah LL, Oestreicher J, Rossman D, Nijhawan N, Rootman J, White V, Williams HJ,<br />
Chang WW, DiBartolomeo A, Howarth D. Xanthogranulomatous disease in the lacrimal gl<strong>and</strong>. Br J Ophthalmol.<br />
89(10):1375-7, <strong>2005</strong>.<br />
Dr. Rita K<strong>and</strong>el<br />
Séguin CA, Pilliar RM, Roughley PJ, K<strong>and</strong>el RA. Tumor necrosis factor-alpha modulates matrix production <strong>and</strong><br />
catabolism in nucleus pulposus tissue. Spine. 30(17):1940-8, <strong>2005</strong>.<br />
Chhaya S, White LM, K<strong>and</strong>el R, Wunder JS, Ferguson P, Agur A. Transarticular invasion of bone tumours across the<br />
sacroiliac joint. Skeletal Radiology Sep 24:1-7, <strong>2005</strong>.<br />
Blacksin MF, White LM, Hameed M, K<strong>and</strong>el R, Patterson FR, Benevenia J. Granular cell tumor of the extremity:<br />
magnetic resonance imaging characteristics with pathologic correlation. Skeletal Radiology 34(10):625-31, <strong>2005</strong>.<br />
Wise LM, Waldman SD, Kasra M, Cheung R, Binnington A, K<strong>and</strong>el RA, White LM, Grynpas MD. Effect of<br />
Zoledronate on Bone Quality in the Treatment of Aseptic Loosening of Hip Arthroplasty in the Dog. Calcif Tissue<br />
Int. 77(6):367-75, <strong>2005</strong>.<br />
Hamilton DJ, Séguin CA, Wang J, Pilliar RM, K<strong>and</strong>el RA. Formation of a Nucleus Pulposus-Cartilage Endplate<br />
Construct in Vitro. Biomaterials. 27(3):397-405, <strong>2006</strong>.<br />
K<strong>and</strong>el R, Li SQ, Bell R, Wunder J, Ferguson P, Kauzman A, Diehl JA, Werier J. Cyclin D1 <strong>and</strong> p21 is Elevated in the<br />
Giant Cells of Giant Cell Tumors. Journal of Orthopaedic Research 24(3):428-37, <strong>2006</strong>.<br />
Waldman SD, Couto DC, Grynpas MD, Pilliar RM, K<strong>and</strong>el RA. A single application of cyclic loading can accelerate<br />
matrix deposition <strong>and</strong> enhance the properties of tissue-engineered cartilage. Osteoarthritis <strong>and</strong> Cartilage 14(4):323-<br />
30, <strong>2006</strong>.<br />
K<strong>and</strong>el RA, Grynpas M, Pilliar R, Lee J, Waldman S, Zalzal P, Hurtig M. Repair of Osteochondral Defects with<br />
Biphasic Cartilage-Calcium Polyphosphate Constructs In a Sheep Model. Biomaterials 27(22):4120-31, <strong>2006</strong>.<br />
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Dr. Sarah Keating<br />
Finkelstein, Y, Chitayat, D., Schechter, T., Keating, S., Toi, A., Koren, G. Warfarin Embryopathy Following<br />
Low Dose Maternal Exposure. Accepted by Obstetrics <strong>and</strong> Gynecology, Canada 27(7): 702-706, July<br />
<strong>2005</strong>.<br />
Ellis, C., Pymar, H., Keating, S., Kingdom, J. Non-compaction of the fetal ventricular myocardium presenting with<br />
reversed end-diastolic flow velocity in the umbilical arteries. JOGC, 27(7):695-698, <strong>2005</strong>.<br />
Slevin, J., Blaser, S., Chitayat, D., Berger, H., Halliday, W., Keating, S., Ryan, G., Toi, A., Pantazi, S., Raybaud,<br />
C. “Intraventricular fused fornices”, a marker for complex midline anomalies. Ultrasound in Obstetrics <strong>and</strong><br />
Gynecology, 26(4): 311, <strong>2005</strong>.<br />
McAuliffe, F.M., Fong, K.W., Toi, A., Chitayat, D., Keating, S., Johnson, J.A. Ultrasound detection of fetal anomalies<br />
in conjunction with first-trimester nuchal translucency screening: a feasibility study. American Journal of Obstetrics<br />
<strong>and</strong> Gynecology,<br />
193(3 Pt 2):1260-1265, <strong>2005</strong>.<br />
Redline, R.W., Heller, D., Keating, S., Kingdom, J. Placental diagnostic criteria <strong>and</strong> clinical correlation – A workshop<br />
report. Placenta, 26(Suppl. A):S114-S117, <strong>2005</strong>.<br />
Dr. Elena Kolomietz<br />
Kolomietz E, Chitayat D, Teshima I. Array-based mapping of the breakpoint regions of familial partial trisomy<br />
11q14.1q22.1 associated with mood disorders for identification of c<strong>and</strong>idate depression-related genes. Am J Med<br />
Genet B Neuropsychiatr Genet. 141(3):214-9., <strong>2006</strong>.<br />
Dr. Iona Leong<br />
Donovan JCH, Hayes RC, Burgess K, Leong IT, Rosen CF. Refractory erosive oral lichen planus associated with<br />
Hepatitis C: Response to topical tacrolimus ointment. J Cutan Med Surg. 9(2):43-6, <strong>2005</strong>.<br />
Dardick I, Bradley G, Lee L, Leong I. Salivary Gl<strong>and</strong> Oral <strong>and</strong> Surgical <strong>Pathology</strong> CD-ROM, <strong>2006</strong>.<br />
Dr. Christina MacMillan<br />
Audet N, Beasley NJ, MacMillan C, Jackson DJ, Gullane PJ, Kamel-Reid S. Lymphatic Vessel Density, nodal<br />
metastases, <strong>and</strong> prognosis in patients with head <strong>and</strong> neck cancer. Arch Otolaryngol Head Neck Surg.,131(12) 1065-<br />
70, <strong>2005</strong>.<br />
Mäkitie AA, Reis PP, Arora S, MacMillan C, Warner GC, Sukhai M, Dardick I, Perez-Ordonez B, Wells R, Brown D,<br />
Gilbert R, Freeman J, Gullane P, Irish J, Kamel-Reid S<br />
Molecular characterization of salivary gl<strong>and</strong> malignancy using the Smgb-Tag transgenic mouse model. Lab Invest.<br />
(Epub ahead of print); Aug;85 (8):947-61, <strong>2005</strong>.
Dr. Brendan Mullen<br />
Aoki VW, Moskovtsev SI, Willis J, Liu L, Mullen JBM, Carrell DT. DNA integrity is compromised in protamine-deficient<br />
human sperm. J Androl, 26:741-8, <strong>2005</strong>.<br />
Moskovtsev SI, Willis J, Mullen JBM. Age-related decline in sperm DNA integrity in patients evaluated for male<br />
infertility. Fertil Steril, 85:496-9, <strong>2006</strong>.<br />
Dr. Frances O’Malley<br />
AL Bane, S Tjan, RK Parkes, I Andrulis, FP O’Malley. Invasive lobular carcinoma: to grade or not to grade. Modern<br />
<strong>Pathology</strong>. 18:621-628, <strong>2005</strong>.<br />
AM. Chiarelli, V Mai, EE. Halapy, RS. Shumak, FP O’Malley, NS. Klar. Effect of screening result on waiting times to<br />
assessment <strong>and</strong> breast cancer diagnosis: Results from the Ontario Breast Screening Program. Canadian Journal of<br />
Public Health 96:259-263, <strong>2005</strong>.<br />
AL Bane, S Tjan, RK Parkes, I Andrulis, FP O’Malley. Invasive lobular carcinoma: to grade or not to grade. Modern<br />
<strong>Pathology</strong>. 18:621-628, <strong>2005</strong>.<br />
TL Mastracci, S Tjan, AL Bane, FP O’Malley, IL Andrulis. E-cadherin alterations in atypical lobular hyperplasia <strong>and</strong><br />
lobular carcinoma in situ of the breast. Modern <strong>Pathology</strong>. 18:741-751, <strong>2005</strong>.<br />
M. Trudeau, S.E. Sinclair, M. Clemons, Breast Cancer Disease Site Group including FP O’Malley. Neoadjuvant<br />
taxanes in the treatment of non-metastatic breast cancer: a systematic review. Cancer Treat Rev. 31:283-302, <strong>2005</strong>.<br />
A. Chiarelli, E Halapy, V Nadalin, R Shumak, FP O’Malley, V Mai. Performance measures from 10 years of breast<br />
screening in the Ontario Breast Screening Program, 1990/91-2000. Eur J Cancer Prev. 15:34-42, <strong>2006</strong>.<br />
FP O’Malley, SK. Mohsin, Sunil Badve, S Bose, MD, LC Collins, M Ennis, CG Kleer, SE Pinder, <strong>and</strong> SJ Schnitt MD<br />
Interobserver Reproducibility in the Diagnosis of flat epithelial atypia of the breast. Modern <strong>Pathology</strong>. 19:172-179,<br />
<strong>2006</strong>.<br />
T A Longacre, M Ennis, L Quenneville, A Bane M.D, I Bleiweiss, B Carter, E Catelano, MR Hendrickson, H Hibshoosh,<br />
L Layfield, L Memeo, H Wu, FP O’Malley. Interobserver agreement <strong>and</strong> reproducibility in diagnosis <strong>and</strong> classification<br />
of invasive carcinoma of the breast: results of the National Cancer Institute (NCI) Familial Registry Breast Cancer<br />
<strong>Pathology</strong> Working Group. Modern <strong>Pathology</strong>. 19:195-207, <strong>2006</strong><br />
KI Pritchard, LE Shepherd, FP O’Malley, I Andrulis, DTu, MN Levine. HER2 <strong>and</strong> Responsiveness of Breast Cancer to<br />
Adjuvant Chemotherapy. New Eng J Med 354: 2103-2111; <strong>2006</strong> (Accompanying editorial: MJ Piccart-Gebhart.<br />
Anthracyclines <strong>and</strong> the tailoring of treatment for early breast cancer. New Eng J Med 354: 2177-2179; <strong>2006</strong>)<br />
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Dr. Hilmi Özçelik<br />
Savas S, Ozcelik H. Phosphorylation states of cell cycle <strong>and</strong> DNA repair proteins can be altered by the nsSNPs. BMC<br />
Cancer 5(1): 107, <strong>2005</strong>.<br />
Cho S, Savas S, Ozcelik H. Genetic variation <strong>and</strong> the mitogen-activiated protein kinase (MAPK) signaling pathway.<br />
OMICS 10(1): 66-81, <strong>2006</strong>.<br />
Savas S, Tuzmen S, Ozcelik H. Human SNPs resulting in premature stop codons <strong>and</strong> protein truncation. Hum<br />
Genomics 2(5): 274-286, <strong>2006</strong>.<br />
Savas S, Schmidt S, Jarjanazi H, Ozcelik H. Functional nsSNPs from carcinogenesis related genes expressed in breast<br />
tissue: Potential breast cancer risk alleles <strong>and</strong> their distribution across human populations. Hum Genomics 2(5): 287-<br />
296, <strong>2006</strong>.<br />
Onay VU, Briollais L, Knight JA, Shi E, Wang Y, Wells S, Li H, Rajendram I, Andrulis IL, Ozcelik. H. SNP-SNP<br />
interactions in breast cancer susceptibility. BMC Cancer 6(1): 114, <strong>2006</strong>.<br />
Prigoda NL, Savas S, Abdalla SA, Piovesan B, Rushblow D, V<strong>and</strong>ez<strong>and</strong>e KE, Zhang EK, Ozcelik H. Gallie BL, Letarte<br />
M. Hereditary haemorrhagic telangiectasia: mutation detection, test sensitivity <strong>and</strong> novel mutations. J Med Genet.<br />
Epub May <strong>2006</strong>.<br />
Pennell CE, Jacobsson B, Williams SM, Buus RM, Muglia LJ, Dolan SM, Morken NH, Ozcelik H, Lye SJ, Prebic<br />
Genetics Working Group, Relton C. Genetic epidemiological studies of preterm birth: Guidelines for research. Am J<br />
Obstet Gynecol epub May <strong>2006</strong>.<br />
Dr. Aaron Pollett<br />
Woods M, Hyde A, Curtis F, Stuckless S, Green J, Pollett A, Robb D, Green R, Croitoru M, Careen A, Chaulk<br />
J, Jegathesan J, McLaughlin J, Gallinger S, Younghusb<strong>and</strong> B, Bapat B, Parfrey P. High Frequency of Hereditary<br />
Colorectal Cancer in Newfoundl<strong>and</strong> Likely Involves Novel Susceptibility Genes. Clinical Cancer Research<br />
11(19):6853 – 6861, <strong>2005</strong>.<br />
Bacani J, Zwingerman R, DiNicola N, Spencer S, Wegrynowski t, Mitchell K, Hay K, Redston M, Holowaty E,<br />
Huntsman D, Pollett A, Riddell R, Gallinger S. Tumour microsatellite instability in early onset gastric cancer. Journal<br />
of Molecular Diagnostics 7(4):465 – 477, <strong>2005</strong>.<br />
Ko MA. Rosario CO. Hudson JW. Kulkarni S. Pollett A. Dennis JW. Swallow CJ. Plk4 haploinsufficiency causes mitotic<br />
infidelity <strong>and</strong> carcinogenesis. Nature Genetics. 37(8):883-8, <strong>2005</strong>.<br />
Dr. Kenneth Pritzker<br />
Yu C, Canteenwala T, Chiang LY, Wilson B, Pritzker KPH: Photodynamic effect of hydrophilic C60-derived<br />
nanostructures for catalytic antitumoral antibacterial application. Synthetic Metals 153: 37-40, <strong>2005</strong>.
Verma S, Padmawar PA, Hauck T, Canteenwala T, Chiang LY, Pritzker KPH: Synthesis of water-soluble highly twophoton<br />
responsive [60]fullerene-diphenylaminofluorene chromophore dyads. J Macromol Sci Pure Appl Chem 42:<br />
1497-1505, <strong>2005</strong>.<br />
Pritzker KPH, Azad A: Bringing biomarkers to clinical practice. Clinical Lab International 25: 24-26, November<br />
<strong>2005</strong>.<br />
Pritzker KPH, Gay S, Jimenez SA, Ostergaard K, Pelletier J-P, Revell PA, Salter D: Osteoarthritis cartilage<br />
histopathology: grading <strong>and</strong> staging. Osteoarthritis <strong>and</strong> Cartilage 14: 13-29, January <strong>2006</strong>.<br />
Dr. Richard Renlund<br />
Kotsopoulos J, Medline A, Renlund R, Sohn K-J, Martin R, Hwang S, Lu S, Archer M <strong>and</strong> KimY-I: Effects of dietary<br />
folate on the development <strong>and</strong> progression of mammary tumours in rats. Carcinogenesis 26: 1603-1612, <strong>2005</strong>.<br />
Dr. Robert Riddell<br />
Silverberg MS, Satsangi J, Ahmad T, Arnott I, Bernstein CN, Brant MD, Caprilli R,<br />
Colombel JF, Gasche C, Geboes K, Jewell DP, Karban A, Loftus EV, Peña AS,<br />
Riddell R H, Sachar DB, Schreier S, Steinhart AH, Targan SR, Vermeire S, Warren BF. Toward an integrated clinical,<br />
molecular <strong>and</strong> serological classification of inflammatory Bowel disease: <strong>Report</strong> of a Working Party of the <strong>2005</strong><br />
Montreal World Congress of<br />
Gastroenterology. Can J Gastroenterol. 19 Suppl A:5-36, <strong>2005</strong>.<br />
Al-Haddad S, Riddell RH. The role of eosinophils in inflammatory bowel disease Gut. 54(12):1674-5, <strong>2005</strong>.<br />
Bacani J, Zwingerman R, Di Nicola N, Spencer S, Wegrynowski T, Mitchell K, Hay K, Redston M, Holowaty E,<br />
Huntsman D, Pollett A, Riddell R, Gallinger S. Tumor Microsatellite Instability in Early Onset Gastric Cancer, J Mol<br />
Diagn. 7(4):465-77, <strong>2005</strong>.<br />
Cunningham KS, Riddell RH. Serrated mucosal lesions of the colorectum.<br />
Curr Opin Gastroenterol. 22(1): 48-53, <strong>2006</strong>.<br />
Bresalier R S, S<strong>and</strong>ler R S, Quan H, Bolognese JA, Oxenius B, Horgan K, Lines C, Riddell RH, Morton D, Lanas<br />
A, Konstam MA, Baron JA, for the Adenomatous polyps Prevention on Vioxx (APPROVe) Trial Investigators.<br />
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial, N Engl J. Med.<br />
355(2):221, <strong>2006</strong>.<br />
Blackstein M, Blay Jean-Yves, Riddell, HR, et al Gastrointestinal stromal tumours (GIST): Consensus statement of<br />
diagnosis <strong>and</strong> treatment. Canadian Journal of Gastroenterology. 20(3) 157-163, <strong>2006</strong>.<br />
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Dr. Patrick Shannon<br />
Shannon P, Bilbao JM, Marotta T, Terbrugge K Inadvertent foreign body embolization in diagnostic <strong>and</strong> therapeutic<br />
cerebral angiography. AJNR Am J Neuroradiol. (2):278-82, <strong>2006</strong>.<br />
Shannon P, Sabha N, Lau N, Kamnasaran D, Gutmann DH, Guha A. Pathological <strong>and</strong> molecular progression of<br />
astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model. Am J Pathol. 167(3):859-67, <strong>2005</strong>.<br />
Laxton AW, Shannon P, Nag S, Farb RI, Bernstein M. Rapid expansion of a previously asymptomatic<br />
subependymoma. Case report. J Neurosurg. 103(6):1084-7, <strong>2005</strong>.<br />
Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H,<br />
McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP.Tyrosine phosphatase MEG2<br />
modulates murine development <strong>and</strong> platelet <strong>and</strong> lymphocyte activation through secretory vesicle function. J Exp<br />
Med. 202(11):1587-97, <strong>2005</strong>.<br />
Zadeh G, Reti R, Koushan K, Baoping Q, Shannon P, Guha A. Regulation of the pathological vasculature of<br />
malignant astrocytomas by angiopoietin-1. Neoplasia. (12):1081-90, <strong>2005</strong>.<br />
Walji S, Rubenstein J, Shannon P, Carette S. Disseminated pyomyositis Disseminated pyomyositis mimicking<br />
idiopathic inflammatory myopathy. J Rheumatol. 32(1):184-7, <strong>2005</strong>.<br />
Dr. Howard Tenenbaum<br />
Rittenberg, B., Partridge, E., Baker, G., Clokie, C., Zohar, R., Dennis, J.W., Tenenbaum, H.C. Regulation of BMPinduced<br />
ectopic bone formation by Ahsg Journal of Orthopaedic Research, May,23(3)653-662, <strong>2005</strong>.<br />
Chun, Y.H., Foster, B.L., Lukasavage, P.A., Berry, J.E., Zhao, M., Tenenbaum, H.C., Somerman, M.J. Bisphosphonate<br />
modulated cementoblast behavior in vitro J. Periodontology , 76(11), 890-990, Nov, <strong>2005</strong>.<br />
Shoval, I., Kushner, J. Sukhu, B., Wood, R., Kiss, T. Lawrence, Tenenbaum, H. . The relationship between<br />
mouthrinse matrix metalloproteinases (MMP-1, 8, 13) <strong>and</strong> albumin levels with the degree of oral mucositis in<br />
allogeneic stem cell transplant patients. Bone Marrow Transplantation (1-6) pg. 654-662, <strong>2005</strong>.<br />
Voronov, I., Heersche, J.N.M., Casper, R.F., Tenenbaum, H.C., Manolson, M.F. Inhibition of osteoclast differentiation<br />
by polycyclic aryl hydrocarbons is dependent on cell density <strong>and</strong> RANKL concentration. Biochemical Pharmacology.<br />
Biochem Pharmacol. May <strong>2005</strong>.<br />
Lekic, P.C., Nayak, B.N., Al-Sanea, R., Tenenbaum, H.C., Ganss, B., McCulloch, C. Cell transplantation in wounded<br />
mixed connective tissues. Anat Rec A Discov Mol Cell Evol Biol. Dec, 287(2): 1256-63, <strong>2005</strong>.<br />
Zohar, R., Tenenbaum, H.C. How predictable are periodontal regenerative procedures? Journal of the Canadian<br />
Dental Association, Oct. 71(9)675-80, <strong>2005</strong>.<br />
Bhide, V., Goldberg, M., Tenenbaum, H.C. Characterization of patients presenting for treatment to a University<br />
Refractory Periodontal Diseases Unit: 3 case reports. J. Periodontol, Feb. 77(2)316-322, <strong>2006</strong>.
Barrett, E.J., Kenny, D.J., Tenenbaum, H.C., Sigal, M.J., Johnston, D.H. Replantation of permanent incisors in children<br />
using Emdogain. Dental Traumatology 21: 269-275,<br />
<strong>2005</strong>.<br />
Shoval, R. <strong>and</strong> Tenenbaum, H.C. Treatment of a m<strong>and</strong>ibular furcation with enamel matrix. Ontario Dentist 83(3):26-<br />
29, <strong>2006</strong>.<br />
Tenenbaum, H.C. <strong>and</strong> Goldberg, M. What should I discuss with my patients who have diabetes <strong>and</strong> periodontal disease<br />
<strong>and</strong> how should this affect management their periodontal problems? JCDA 72:38-39, <strong>2006</strong>.<br />
Dr. Theo van der Kwast<br />
Van der Aa MN, van Leenders GJ, Steyerberg EW, van Rhijn BW, Jobsis AC, Zwarthoff EC, Van der Kwast TH. A new<br />
system for substaging pT1 papillary bladder cancer: a prognostic evaluation. Hum Pathol. 36(9):981-6, <strong>2005</strong>.<br />
Van Duin M, van Marion R, Vissers K, Watson JE, van Weerden WM, Schroder FH, Hop WC, Van der Kwast TH, Collins<br />
C, van Dekken H. High-resolution array comparative genomic hybridization of chromosome arm 8q: evaluation of<br />
genetic progression markers for prostate cancer. Genes Chromosomes Cancer. 44(4):438-49, <strong>2005</strong>.<br />
Schroder FH, Raaijmakers R, Postma R, Van der Kwast TH, Roobol MJ. 4-year prostate specific antigen progression <strong>and</strong><br />
diagnosis of prostate cancer in the European R<strong>and</strong>omized Study of Screening for Prostate Cancer, section Rotterdam.J<br />
Urol. 174(2):489-94, <strong>2005</strong>.<br />
Ma X, Ziel-van der Made AC, Autar B, van der Korput HA, Vermeij M, van Duijn P, Cleutjens KB, de Krijger R,<br />
Krimpenfort P, Berns A, Van der Kwast TH, Trapman J. Targeted biallelic inactivation of Pten in the mouse prostate leads<br />
to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res.<br />
65(13):5730-9, <strong>2005</strong>.<br />
van der Cruijsen-Koeter IW, Vis AN, Roobol MJ, Wildhagen MF, de Koning HJ, Van der Kwast TH, Schroder FH.<br />
Comparison of screen detected <strong>and</strong> clinically diagnosed prostate cancer in the European r<strong>and</strong>omized study of screening<br />
for prostate cancer, section Rotterdam. J Urol 174(1):121-125, <strong>2005</strong>.<br />
Postma R, van Marion R, van Duin M, Vissers KJ, Schroder FH, Tanke HJ, Szuhai K, Van der Kwast TH, van Dekken H.<br />
Array-based genomic analysis of screen-detected Gleason score 6 <strong>and</strong> 7 prostatic adenocarcinomas. Anticancer Res.<br />
(2A): 1193-200, <strong>2006</strong>.<br />
Van der Kwast TH, Roobol MJ. Can PSA density be used to detect prostate cancer? Nat Clin Pract Urol. (3): 130-1,<br />
<strong>2006</strong>.<br />
Roemeling S, Roobol MJ, de Vries SH, Gosselaar C, Van der Kwast TH, Schroder FH. Prevalence, treatment modalities<br />
<strong>and</strong> prognosis of familial prostate cancer in a screened population.J Urol. 175 (4): 1332-6, <strong>2006</strong>.<br />
Schroder FH, Roobol MJ, Van der Kwast TH, Kranse R, Bangma CH. Does PSA velocity predict prostate cancer in prescreened<br />
populations? Eur Urol. <strong>2006</strong> March: 49 (3): 460-5: discussion 465. Epub <strong>2006</strong>.<br />
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Postma R, van Leenders GJ, Roobol MJ, Schroder FH, Van der Kwast TH. Tumor Features in the Control <strong>and</strong><br />
Screening Arm of A R<strong>and</strong>omized Trial of Prostate Cancer.Eur Urol. (Epub ahead of print), <strong>2005</strong>.<br />
Van der Kwast TH. Substaging pathologically organ confined (pT2) prostate cancer: an exercise in futility? Eur Urol.<br />
49 (2): 209-11. Epub, <strong>2006</strong>.<br />
Verhagen PC, van Duijn PW, Hermans KG, Jooijenga LH, van Gurp RJ, Stoop H, Van der Kwast TH, Trapman J. The<br />
PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion. J Pathol. 208<br />
(5): 699-707, <strong>2006</strong>.<br />
Gosselaar C, Roobol MJ, Roemeling S, de Vries SH, Cruijsen-Koeter I, Van der Kwast TH, Schroder FH. Screening<br />
for prostate cancer without digital rectal examination <strong>and</strong> transrectal ultrasound: results after four years in the<br />
European R<strong>and</strong>omized Study of Screening for Prostate Cancer (ERSPC), Rotterdam. Prostate. 66 (6): 625-31, <strong>2006</strong>.<br />
Van der Kwast TH, Ciatto S, Martikainen PM, Hoedemacker R, Laurila M, Pihl CG, Hugosson J, Neetens I, Nelen V,<br />
Di Lollo S, Roobol MJ, Maatanen L, Santonja C, Moss S, Schroder FH. Detection rates of high-grade prostate cancer<br />
during subsequent screening visits. Results of the European R<strong>and</strong>omized Screening Study for Prostate Cancer. Int J<br />
Cancer: 118 (10): 2538-42, <strong>2006</strong>.
Dr. S<strong>and</strong>ra Viero<br />
Price VE, Fletcher JA, Zielenska M, Cole W, Viero S, Manson DE, Stuart M, Pappo AS: Imatinib mesylate: an<br />
attractive alternative in young children with large, surgically challenging dermatofibrosarcoma protuberans. Pediatr<br />
Blood Cancer, 44:1-5, <strong>2005</strong>.<br />
Jaeger MRO, Viero S, Zuker RM: Cutaneous ganglioneuroma within a giant congenital nevus. Can J Plast Surg,<br />
13(1):39-42, <strong>2005</strong>.<br />
Somers GS, Viero S, Teshima I, Nathan P, Zielenska M. Association of the t(12;22)(q13;q12) EWS/ATF1<br />
rearrangement with primary sarcoma of bone. American Journal of Surgical <strong>Pathology</strong>, 29:1673-1679, <strong>2005</strong>.<br />
Edwards V, Cutz E, Viero S, Moore AM, Nogee L. Ultrastructure of lamellar bodies in congenital surfactant<br />
deficiency. Ultrastructural <strong>Pathology</strong>, 29(6):503-509, <strong>2005</strong>.<br />
Bader R, Hornberger LK, Nijmeh LJ, Al-Kazaleh F, Ryan G, Toi A, Viero S, Butany J, Chitayat D. Fetal pericardial<br />
teratoma: presentation of two cases <strong>and</strong> review of literature. Am J Perinatol, 23(1):53-8, <strong>2006</strong>.<br />
Alkazaleh F, Chaddha V, Viero S, Malik A, Anastasiadis C, Sroka H, Chitayat D, Toi A, Windrim R, Kingdom J:<br />
Second trimester prediction of severe placental implications in women with combined elevations in alpha-<br />
fetoprotein <strong>and</strong> human chorionic gonadotrophin. American Journal of Obstetrics <strong>and</strong> Gynecology, 194:821-7,<br />
<strong>2006</strong>.<br />
Yeung J, Somers G, Viero S, Pope E: Multifocal lymphangioendotheliomatosis with thrombocytopenia. Journal of<br />
the American Academy of Dermatology, 54:S214-217, <strong>2006</strong>.<br />
Milic A, Blaser S, Robinson A, Viero S, Halliday W, Winsor E, Toi A, Thomas M, Chitayat D: Prenatal detection of<br />
microtia by MRI in a fetus with trisomy 22. Pediatr Radiol, <strong>2006</strong> Epub.<br />
Baker JM, Viero S, Kim PC, Grant RM. Stage III Cystic Partially Differentiated Nephroblastoma recurring after<br />
nephrectomy <strong>and</strong> chemotherapy. Pediatric Blood <strong>and</strong> Cancer, <strong>2006</strong> Epub.<br />
Dr. Reinhold Vieth<br />
Chow E, Hoskin PJ, Wu J, Roos D, van der Linden Y, Hartsell W, Vieth R, Wilson C, Pater J.A phase III international<br />
r<strong>and</strong>omised trial comparing single with multiple fractions for re-irradiation of painful bone metastases: National<br />
Cancer Institute Of Canada Clinical Trials Group (NCIC CTG) SC 20.Clin Oncol (R Coll Radiol). Mar;18(2):125-8,<br />
<strong>2006</strong>.<br />
Vieth R, Kimball S, Vitamin D in congestive heart failure, Am J Clin Nutr. <strong>2006</strong> Apr;83(4):731-2.R Vieth. Critique<br />
of the Considerations for Establishing Tolerable Upper Intake Levels for Vitamin D. J Nutr. 136(4):1117-22, <strong>2006</strong>.<br />
El-Hajj FG, Nabulsi M, Tamim H et al. Effect of vitamin D replacement on musculoskeletal parameters in school<br />
children: a r<strong>and</strong>omized controlled trial. J Clin Endocrinol Metab 91:405-12, <strong>2006</strong>.<br />
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67
Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status.<br />
Osteoporos Int 16:713-6, <strong>2005</strong>.<br />
Vieth R, Cole DE. Teriparatide, osteoporosis, calcium, <strong>and</strong> vitamin D. N Engl J Med 353:634-5, <strong>2005</strong>.<br />
Vieth R. The role of vitamin D in the prevention of osteoporosis. Ann Med 37:278-85, <strong>2005</strong>.<br />
Vieth R, El-Hajj FG. There is no lower threshold level for parathyroid hormone as 25-hydroxyvitamin D<br />
concentrations increase. J Endocrinol Invest 28:183-6, <strong>2005</strong>.<br />
Vieth R, El-Hajj Fuleihan G. There is no lower threshold level for parathyroid hormone as 25-hydroxyvitamin D<br />
concentrations increase. J Endocrinol Invest 28:183-6, <strong>2005</strong>.<br />
Woo TC, Choo R, Jamieson M, Ch<strong>and</strong>er S, Vieth R. Pilot Study: Potential Role of Vitamin D (Cholecalciferol) in<br />
Patients With PSA Relapse After Definitive Therapy. Nutr.Cancer 51:32-6, <strong>2005</strong>.<br />
Dr. Chen Wang<br />
Zheng J, Ghazani A, Song Q, Mardyani S, Chan W, Wang C. Cellular imaging <strong>and</strong> surface marker labeling of<br />
hematopoietic cells using quantum dot bioconjugates , Lab. Hematology, 12:94-98, <strong>2006</strong>.<br />
Dr. Elizabeth Winsor<br />
Winsor EJT, Windrim R, Ryan G, Seaward G, Chitayat D, Akoury H Success rate for culture of fetal postmortem<br />
tissue is dependent on the method of pregnancy termination. Fetal Diag Ther 20(4):306-308, <strong>2005</strong>.<br />
Kolomietz E, Godbole K, Winsor EJT, Stockley T, Seaward G, Chitayat D Functional disomy of Xp: prenatal findings<br />
<strong>and</strong> postnatal outcome. Amer J Med Genetics 134A: 393-398, <strong>2005</strong>.<br />
Bruyere H, Speevak MD, Winsor EJT, de Freminville B, Farrell SA, McGowan-Jordan J, McGillivray B, Chitayat D,<br />
McFadden D, Adouard V, Terespolsky D, Prieur F, Pantzar T, Hrynchak M. Isodicentric Yp: prenatal diagnosis <strong>and</strong><br />
outcome in twelve cases. Prenat Diagn 26: 324-329, <strong>2006</strong>.<br />
Milic A, Blaser S, Robinson A, Viero S, Halliday W, Winsor E, Toi A, Thomas M,<br />
Chitayat D. Prenatal detection of microtia by MRI in a fetus with trisomy 22. Pediatr Radiol 36(7):706-710, <strong>2006</strong>.
BOOKS & BOOK CHAPTERS<br />
Dr. Bharati Bapat<br />
Buonogiorno, P. <strong>and</strong> Bapat, B. Invited Chapter “Rho GTPases <strong>and</strong> Cancer”, in Developmental Biology of Neoplastic<br />
Growth. Edited by Dr. Alvaro Macieira-Coelho. Springer-Verlag <strong>2005</strong>.<br />
Raptis, R., <strong>and</strong> Bapat, B. Invited Chapter “Genetic Instability in Human Tumors”, in Cancer: Cell Structures,<br />
Carcinogens <strong>and</strong> Tumor Pathogenesis. Edited by Dr. L. Bignold. Birkhauser-Verlag, <strong>2005</strong>. EXS 96: 303-320, <strong>2006</strong>.<br />
Dr. Steven Gallinger<br />
Zogopoulos G, Gallinger S: Modifiers of Risk in Familial Adenomatous Polyposis. Current Colorectal Cancer<br />
<strong>Report</strong>s – Invited Review <strong>2006</strong>.<br />
MEDIA RECOGNITION<br />
Dr. Reinhold Vieth<br />
National Post, June National Post Tuesday, June 14, <strong>2005</strong> Page: FP23 Section: Financial Post: Comment Byline:<br />
Reinhold Vieth. Financial Post Edition: National Story Type: Business; Opinion: A healthy tan: Excess exposure may<br />
be hard on the skin, but the healthful effects of UV outweigh skin cancer <strong>and</strong> melanoma risks.<br />
National Post, June National Post Tuesday, June 15, <strong>2005</strong> Page: FP23 Section: Financial Post: Comment Byline:<br />
Reinhold Vieth. Financial Post Edition: National Story Type: Business; Opinion: ‘D’ depravation: There’s no problem<br />
with vitamin D intakes to at least 10,000 units per day. But the junkiest science rules with an official safe limit of<br />
only 1,000 units.<br />
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69
APPENDIX A<br />
Medical <strong>and</strong> Scientific Staff as at June 30, <strong>2006</strong><br />
Pathologist-in-Chief<br />
Pritzker, Dr. K.P.H.<br />
Medical Staff<br />
Bédard, Dr. Yvan Bromberg, Dr. Irvin Colgan, Dr. Terry Fern<strong>and</strong>es, Dr. Bernard<br />
Howarth, Dr. David K<strong>and</strong>el, Dr. Rita Keating, Dr. Sarah MacMillan, Dr. Christina<br />
Mullen, Dr. Brendan O’Malley, Dr. Frances Pollett, Dr. Aaron Riddell, Dr. Robert<br />
Shannon, Dr. Patrick Van der Kwast, Dr. Theo Wang, Dr. Chen<br />
Associate Scientific Staff<br />
Andrulis, Dr. Irene Azad, Dr. Azar Bapat, Dr. Bharati Chiang, Dr. Long<br />
Cruz, Dr. Tony Denomme, Dr. Gregory Diam<strong>and</strong>is, Dr. Eleftherios Grynpas, Dr. Marc<br />
Hoffman, Dr. Barry Khosravi, Dr. Javad Kolomietz, Dr. Elena McKerlie, Dr. Colin<br />
Özçelik, Dr. Hilmi Renlund, Dr. Richard Vieth, Dr. Reinhold Winsor, Dr. Elizabeth<br />
Associate Medical Staff<br />
Asa, Dr. Sylvia Chapman, Dr. William Fantus, Dr. George Gallinger, Dr. Steven<br />
Jarvi, Dr. Keith Jong, Dr. Rol<strong>and</strong> Lajoie, Dr. Ginette Leong, Dr. Iona<br />
Mock, Dr. David Patterson, Dr. Bruce Ruijs, Dr. Theodora Tenenbaum, Dr. Howard<br />
Viero, Dr. S<strong>and</strong>ra<br />
Consultant Staff<br />
Blumenthal, Dr. Andrea Gotlieb, Dr. Avrum Machin, Dr. Geoff Summers, Dr. Anne<br />
Honorary Medical Staff<br />
Abbott, Dr. Derrick Cooter, Dr. Noel Luk, Dr. Shing Chark Musclow, Dr. Elizabeth<br />
Nyburg, Dr. Stanley Pollard, Dr. Alan Ritchie, Dr. Alex Strawbridge, Dr. Harry<br />
Research Associates<br />
Gokgoz, Nalan Dumitriu, Mircea
APPENDIX A (con’t)<br />
Medical <strong>and</strong> Scientific Staff as at June 30, <strong>2006</strong><br />
Administrative Support Staff<br />
D’Mello, Mr. Vince, Administrative Director<br />
Vaccaro, Ms. Anna,Supervisor, Financial & Professional Affairs<br />
Mendes, Ms. Maria,Manager, Research Services<br />
Krakower, Ms. S<strong>and</strong>ra,Manager, Rapid Response <strong>Laboratory</strong><br />
Hon, Mr. Joseph, Systems <strong>and</strong> Special Projects Officer<br />
McPherson, Mr. David, <strong>Laboratory</strong> Information Systems Officer<br />
Modi, Mr. Gaman, Quality Assurance Co-ordinator<br />
Wilkins, Ms. Dorothy,Co-ordinator, Maternal Serum Screening Program<br />
Tzountzouris, Mr. John, Supervisor, Genetics <strong>and</strong> Molecular Diagnostics<br />
Bergeron, Ms. Nancy, Supervisor, Hematopathology<br />
Wolff, Mr. Alan, Supervisor, Pathologists’ Assistants<br />
Hutton, Ms. Nancy, Supervisor, Patient Services<br />
Machin, Ms. Cynthia, Supervisor, Administrative Support Services (on leave)<br />
Everson, Ms. Melody, Acting Supervisor, Administrative Support Services<br />
Pirogowicz, Ms. Theresa, Assistant to Pathologist-in-Chief <strong>and</strong> Director
APPENDIX B<br />
Technical & Support Staff as at June 30, <strong>2005</strong><br />
Charge Technologists<br />
Eva Cappa Bessie Carydis Cyndy Dunn Ewa Latawiec<br />
Keith Lau Cecilia Moller<br />
Technologists<br />
Danny Appadoo Jennifer Au Angie Bansil Melanie Bernabe<br />
Mladenka Bilal Glen Booth Audrey Braschel Aileen Brown<br />
Ben Centeno Ann Chan Janet Chan Rosalina Chan<br />
Hong Cheng Yvonne Chin Kim Chrisztopulosz Jan Church<br />
Megan Cook Michelle Cornect Laurie Deboer Maria de la Vega<br />
Ranjit Dhariwal Zubeida Dinani N<strong>and</strong>o Di Nicola Keyur Dixit<br />
Navin Dudhara Tammy Earle Carla Emanuele Angelo Fefekos<br />
Laura Feness Kelly Fenwick Rafael Floro NaiChong Gan<br />
Valentino Giorno Nancy Good Heather Goodchild Clara Goodwin<br />
Jamshid Hadidi Lynda Harrington Seyeda Hasany Cherry Have<br />
Marta Hnatovska Doug Holmyard Patricia Hooshley-Inch Glen Hopkins<br />
Shukri Hirsi Chetankumar Jariwala Donna Johnson Badry Kashafi<br />
Ian Kerr Entela Ketri Samantha Kimball Joyce Kitazaki-Lee<br />
Gordana Kuruzar Catherine Lacsamana Melanie Leffler Patrick Legault<br />
Holly Maddison Usha Majeed Lynette Manansingh Daniella Martino<br />
Debra McKay Maria Mendes Ann Miller Olga Mischuk<br />
Ionela Mitroi Angela Mitri Tatiana Mnich Jonathan Modo<br />
Sathasivan Moodley Jana Muravska Jiann Ng-Kcomt Ruoyu Ni<br />
Anayo Okorie Pam Olins Monica Orozco-Muga Alice Pal<br />
Louis Papaeliou Shakuntala Patel Lumen Penaflorida Jacqueline Pittman<br />
Cynthia Pokulok Elena Ramach<strong>and</strong>ran Rick Ramdhanie Lily Ramyar<br />
Mona Reid Florence Reyes Lisa Robinson Mary Joe Rodrigues<br />
Michelle Rodrigues Marianne Rogers Eileen Ross A. Rucinska-Woznowski<br />
Carol S<strong>and</strong>iford Manwinderjit Sangha Teresa Sel<strong>and</strong>er Fredericka Shaw<br />
Xiuhong Shi Theodora Shizas Teresa Shortill Shirley Siu<br />
Shelly Soloman Aida Stefan Zuzanna Suler David Swanson<br />
Shafqat Tahir Andrea Taylor Suzanna Tjan S<strong>and</strong>ra Toma Paciocco<br />
Jindra Tupy Kerri Tupy Ruth Vives Trish Wegrynowski<br />
John White Dorothy Wilkins Gloria Willer Frances Williams<br />
Jennifer Willis Anne Wilson Mathews Tony Wing Catherine Winning<br />
Anna Wong Jasmine Wong Marie Wong Martha Wood<br />
Monica Woroszchuk Agnes Wozniarski Denise Yee Samuel Yesurathnam<br />
Rebecca Yiu Danielle Yott Brenda Zelazny Lorna Zilic<br />
Zoran Zilic
APPENDIX B (con’t)<br />
Technical & Support Staff as at June 30, <strong>2005</strong><br />
Technicians<br />
Emanuel Abelha Maria Ackermann Carmen Alimagno Linda Anjos<br />
Tammy Baliat June Bankasingh Aileen Baretto Raffi Berberian<br />
Layla Bhanji Cecilia Bolarinho Vanessa Bothel Melody Cacao<br />
Priscilla Chan Aileen Coore Elsa de Guzman Olarte Leonila de la Gana<br />
Jagath Dissanayake Yasas Dissanayake Domenica Filleti Sukhwinder Girn<br />
Krystyna Golen Ilona Gomolka Natalie Henry Elizabeth Iles<br />
Elaine Isaac Angela Johnson Cass<strong>and</strong>ra Johnson-Berry Joanna Jones<br />
Maureen Joseph Iwona Kloc Susan Lau Susie Livingstone<br />
Jo Jo Lopez Julie Marr Orissia Masliak Opal McDonald<br />
Dana Miclea Maria Murdoch Abiola Oduwole Elsa Olarte<br />
Olga Ostrovsky Anita Patel Roslyn Payne Sealey Sonia Pennant<br />
Phyllis Perreira Carol Peters Maria Ramos Patricia Saban<br />
Anne Sankadayal Jo-Ann Santos Alina Senkus Millicent Sharpe<br />
Avshag Shimova Carolyn Smart Ramesh Shah Anna Szufnara<br />
Maria Tabujara Dorota Talkowska Luz Vallarit<br />
General Support Staff<br />
Judy Austin Ursula Carter Domenica Filleti Soo Kim<br />
Ruth Krisa Rosalinda Pizzuto Cynthia Machin Hassima Omar Ali<br />
Sylvia Perez Julie Precious Chelo Shall<strong>and</strong> Claudia Sopora<br />
Maureen Spencer Anna Tang Rina Varga<br />
Lab Informatics Staff<br />
Tom Hatch David McPherson Anna Latour<br />
Nurse<br />
Lori Kingdon<br />
Pathologists’ Assistants<br />
Brian Chow Sarah James Megan Thompson Alan Wolff<br />
Autopsy Technician<br />
Larry Quaranto
APPENDIX C<br />
Technical & Support Staff Changes<br />
Departures<br />
Clerical Services<br />
Ana Broomes Rosanna Moutsanas Indra Narula Isabelle Schell<br />
Cytopathology<br />
Stephen Leung<br />
Rapid Response <strong>Laboratory</strong><br />
Jacqueline Cheng Elisabeth Miedema<br />
Special Chemistry<br />
Adnan Khan<br />
Special Histology<br />
Yasas Dissanayake Entela Ketri<br />
New Staff<br />
Andrology<br />
June Serote<br />
Cytogenetics<br />
Valerie Foster<br />
Hematology<br />
Wei Liu Lisa Manning<br />
Molecular <strong>Pathology</strong><br />
Megan Jensen Matthew Vlasschaert<br />
Patient Services<br />
Sagar Bedakar<br />
Special Chemistry<br />
Homa Bondar<br />
Special Histology<br />
Julitta Drab Mona Reid
APPENDIX D<br />
Residents<br />
Dickson, Brendan (Anatomic <strong>Pathology</strong>/Cytopathology)<br />
Timonera, Elizabeth (Anatomic <strong>Pathology</strong>)<br />
Nair, Vidhya (Anatomic <strong>Pathology</strong>)<br />
Cunningham, Kristopher (Anatomic <strong>Pathology</strong>/Gyne)<br />
Aljawad, Hameed (Sarcoma)<br />
Aljerian, Khaldoon (Surgical <strong>Pathology</strong>/Sarcoma)<br />
Jaragh, Mohammad (Cytopathology/Head <strong>and</strong> Neck)<br />
Al-Shraim, Mubarak (Sarcoma)<br />
Arwini, Ahmed (Cytopathology)<br />
Hazrati, Lily-Naz (Sarcoma)<br />
Winer, Daniel (Sarcoma)<br />
Djordevic, Bojana (Anatomic <strong>Pathology</strong>/Sarcoma)<br />
Kennedy, Meagan (Breast <strong>Pathology</strong>)<br />
Weinreb, Ilan (Soft tissue/bone)<br />
Craddock, Ken (Anatomic <strong>Pathology</strong>)<br />
Kepron, Charis (Anatomic <strong>Pathology</strong>)<br />
Gunapalan, Lalitha (Anatomic <strong>Pathology</strong>/Hemat)<br />
Good, David (Hematopathology)<br />
El Demallawy, Dina (Anatomic <strong>Pathology</strong>/Cytopathology)<br />
Faghfoury, Hanna (Fetal <strong>Pathology</strong>)<br />
Chung, Catherine (Breast <strong>Pathology</strong>)<br />
Akpan, Domenic (<strong>Pathology</strong> elective – Nigeria)<br />
Kim, Susan (Gynepathology elective – UBC)<br />
Van den Bosch, Ilse (<strong>Pathology</strong> elective – Holl<strong>and</strong>)<br />
Hancock, Laura (<strong>Pathology</strong> elective – Engl<strong>and</strong>)<br />
McDermott, Colleen (Gynepathology elective)<br />
Baratz, Ari (Gynepathology elective)<br />
Al-Riyami, Nihal (Gynepathology elective)<br />
Lee, Sabrina (Gynepathology elective)<br />
Fried, Eve (Gynepathology elective)<br />
Sierra, Neelam (Gynepathology elective)<br />
Wilson Myckan, Kerry (Gynepathology elective)<br />
Spitzer, Rachel (Gynepathology elective)<br />
Torres, Nathalia<br />
Rai, Sundeep (General Surgery)<br />
Huynh, Quoc Hung (General Surgery)<br />
Barsuk, Daphna (General Surgery)<br />
Devon, Karen (General Surgery)<br />
Kundhal, Pavi (General Surgery)<br />
Asaria, Jamil (General Surgery)<br />
Gladdy, Rebecca (General Surgery)<br />
Chan, Ida (Radiology)<br />
James, Susan (Radiology)<br />
Gao, Zuhua (MD elective – GI <strong>Pathology</strong>)
APPENDIX E<br />
Fellows<br />
Las Heras, Facundo (Bone <strong>and</strong> Soft tissue)<br />
MacNeill, Nicki (Gyne)<br />
Dube, Valerie (Gyne)<br />
Mulligan, Anna Marie (Breast)<br />
Bane, Anita (Breast)<br />
Curtis, Michael (Cytopathology)<br />
George, Anne (Cytogenetics)<br />
Bishop, Karen (Fetal <strong>Pathology</strong>)<br />
Kirsch, Richard (GI <strong>Pathology</strong>)<br />
Hussein, Nusrat (Fetal <strong>Pathology</strong>)
APPENDIX F<br />
Graduate Students <strong>2005</strong>-<strong>2006</strong><br />
Student Supervisor PhD or<br />
MSc<br />
Thesis Title/Project<br />
Bane, Anita Andrulis, Dr. Irene MSc Familial Breast Cancer: BRCA2 <strong>and</strong> Beyond, Histopathologic <strong>and</strong> Molecular Phenotype<br />
Duygu, Acar Andrulis, Dr. Irene MSc Identification of novel gains <strong>and</strong> losses in early onset of breast cancer by CGH<br />
Huggins, Christopher Andrulis, Dr. Irene PhD Identification of BRCA2 interacting proteins<br />
Forse, Catherine Andrulis, Dr. Irene MSc Identification of genes involved in lymphatic invasion in breast cancer<br />
Keszei, Andras Andrulis, Dr. Irene PhD Role of the thiazide-sensitive NaCe contransporter gene is essential hypertension<br />
Lo, Winnie Andrulis, Dr. Irene MSc Molecular analysis of osteosarcoma<br />
Mastracci, Teresa Andrulis, Dr. Irene PhD Methylation of the LAF-4 gene<br />
Seto, Kelly Andrulis, Dr. Irene MSc Identification of novel genetic changes during development <strong>and</strong> progression of ovarian<br />
cancer<br />
Buongiorno, Pinella Bapat, Dr. Bharati MSc Analysis of downstream targets of Rac 1 GTPase <strong>and</strong> Wnt signaling pathway<br />
Charames, George Bapat, Dr. Bharati PhD Analysis of downstream targets of Rac 1 GTPase <strong>and</strong> Wnt signaling pathway<br />
Esufali, Susie Bapat, Dr. Bharati PhD Structure-function analysis of proteins integrating with ARM domain of tumor<br />
suppression APC <strong>and</strong> its significance in Wnt pathway<br />
Mrkonjic, Miralem Bapat, Dr. Bharati MSc The role of MMR SNP’s in the development of colorectal cancer in two Canadian<br />
populations<br />
Perera, Sheron Bapat, Dr. Bharati MSc Functional analysis of inherited genetic variants in MMR genes associated with CRC<br />
predisposition<br />
Raptis, Roula Bapat, Dr. Bharati MSc Association studies of MMR polymorphisms <strong>and</strong> colorectal cancer risk.<br />
Borgono, Carla Diam<strong>and</strong>is, Dr.<br />
Eleftherios<br />
Cho, Jane Diam<strong>and</strong>is, Dr.<br />
Eleftherios<br />
Gunawardana, Geeth Diam<strong>and</strong>is, Dr.<br />
Eleftherios<br />
Kulasingam, Vathany Diam<strong>and</strong>is, Dr.<br />
Eleftherios<br />
Memari, Nader Diam<strong>and</strong>is, Dr.<br />
Eleftherios<br />
Oikonomopoulou, Diam<strong>and</strong>is, Dr.<br />
Katerina<br />
Eleftherios<br />
Prassas, John Diam<strong>and</strong>is, Dr.<br />
Eleftherios<br />
Sardana, Girish Diam<strong>and</strong>is, Dr.<br />
Eleftherios<br />
Shan, Shannon Diam<strong>and</strong>is, Dr.<br />
Eleftherios<br />
Shaw, Julie Diam<strong>and</strong>is, Dr.<br />
Eleftherios<br />
PhD Human kallikrein 14: biological relevance <strong>and</strong> clinical significance<br />
MSc Proteomic discovery of potential biomarkers of chromosomal abnormalities from<br />
amniotic fluid<br />
PhD Identification of tumor associated antigents <strong>and</strong> their auto-antibodies in ovarian<br />
cancer<br />
PhD Discovery of novel biomarkers for early breast cancer diagnosis using proteomics <strong>and</strong><br />
mass spectrometry<br />
PhD Cloning, protein purification <strong>and</strong> molecular characterization of hK12<br />
PhD The involvement of the kallikreins in neurogenative disease<br />
MSc Identification of tissue-specific kallikrein inhibitors<br />
MSc Identification of Novel Ovarian Cancer Biomarkers<br />
MSc Regulation of human kallikrein 6 in ovarian carcinoma<br />
PhD Characterization of human kallikrein 15: recombinant protein production, antibody<br />
generation, detection in body fluids <strong>and</strong> study of enzymatic activity <strong>and</strong> substrates.<br />
Chiu, Andrew Grynpas, Dr. Marc MSc Role of vanadium on bone remodelling in the rat model Phase II<br />
Khan, Tayyab Grynpas, Dr. Marc MSc Characterize the skeletal phenotype of the Sca-1 KO mice <strong>and</strong> identify the mechanistic<br />
cellular pathways underlying it.<br />
Omelon, Sidney Grynpas, Dr. Marc PhD Mechanisms of formation <strong>and</strong> dissolution of calcium polyphosphates
Student Supervisor PhD or<br />
MSc<br />
Thesis Title/Project<br />
Hunt, Tanya Grynpas, Dr. Marc MSc Can Vitamin D delay or arrest the progression of osteoarthritis in an animal model<br />
Rowe, Elizabeth Grynpas, Dr. Marc MSc The Skeletal Effects of a Growth Hormone-Derived Peptide (AOD9604) in the Aged<br />
Rat Model of Postmenopausal Osteoporosis.<br />
Ue, Judy Grynpas, Dr. Marc MSc The structure <strong>and</strong> chemistry of calcium polyphosphates<br />
Wise, Lisa Grynpas, Dr. Marc PhD Recombinant differentiation experiments on the Bax mouse model.<br />
Wynnyckyj, Chrystia Grynpas, Dr. Marc PhD Ex-vivo model on bone fatigue.<br />
Arana, Claudia K<strong>and</strong>el, Dr. Rita MSc Effects of cartilage endplate on nucleus pulposus cells<br />
Chang, Godfrey K<strong>and</strong>el, Dr. Rita MSc Growing annulus fibrosis on porous 3D silk scaffold.<br />
Spiteri, Caroline K<strong>and</strong>el, Dr. Rita MSc Chondrocyte adhesion to CPP<br />
St. Pierre, Jean-Phillipe K<strong>and</strong>el, Dr. Rita PhD Growing of deep zone chondrocytes onto titanium porous 3D scaffolds<br />
Cho, Stewart Ozcelik, Dr. Hilmi MSc Single Nucleotide Polymorphisms <strong>and</strong> the Ras Dependent Pathway: Recipe for cancer?<br />
Fehringer, Gord Ozcelik, Dr. Hilmi PhD Family based study of the association of the IGF-1 gene with breast cancer <strong>and</strong> breast<br />
density<br />
So, Grace Pritzker, Dr. Kenneth MSc Alkaline phosphatase inhibitors <strong>and</strong> CPPD arthropathy<br />
So, Pauline Pritzker, Dr. Kenneth MSc Endogenous Inhibitors of Cartilage Alkaline Phosphatase <strong>and</strong> Calcium Pyrophosphate<br />
Bielawski, Donna Tenenbaum, Dr.<br />
Howard<br />
Girard, Bruno Tenenbaum, Dr.<br />
Howard<br />
Haytham, Ibrahim Tenenbaum, Dr.<br />
Howard<br />
Muirhead, Vanessa Tenenbaum, Dr.<br />
Howard<br />
Voronov, Irina Tenenbaum, Dr.<br />
Howard<br />
Crystal Deposition Disease<br />
MSc Neuropsychological cognitive predictors of treatment outcomes following<br />
physiotherapy in patients with TMD<br />
PhD Bone cutting lasers<br />
MSc Pain <strong>and</strong> C-Fos expression in the brain<br />
MSc Effects of chronic orofacial pain on significant others in the family<br />
PhD Aryl hydrocarbons affect bone resorption <strong>and</strong> by inhibiting osteogenesis <strong>and</strong> these<br />
effects can be reversed by Resveratrol in vitro.
APPENDIX F (con’t)<br />
Graduate Students <strong>2005</strong>-<strong>2006</strong><br />
Faculty of Applied Science <strong>and</strong> Engineering Undergraduate Project Students, Nanotechnology<br />
Student Supervisor Thesis Title/Project<br />
So, Grace<br />
Materials Science <strong>and</strong><br />
Engineering<br />
Lee, Lawrence<br />
Engineering Science<br />
Pritzker, Dr. Kenneth Characterization of Hydrophobic Fullerene Derivatives <strong>and</strong> Liposome Formulations for Potential<br />
Applications in Photodynamic Therapy<br />
Pritzker, Dr. Kenneth Characterization <strong>and</strong> Gold-Doping of Hexadecaanilinated Carbon Nanotubes<br />
Faculty of Arts <strong>and</strong> Sciences, <strong>Laboratory</strong> <strong>Medicine</strong> <strong>and</strong> Pathobiology,<br />
Undergraduate Project Students<br />
Student Supervisor Thesis Title/Project<br />
Hadzocos, Edward K<strong>and</strong>el, Dr. Rita P53 <strong>and</strong> benign breast disease<br />
Raizman, Igal K<strong>and</strong>el, Dr. Rita Mechanical stimulation <strong>and</strong> its effect on the different zones of cartilage<br />
Kanampuza, Jovil Pritzker, Dr. Kenneth Calcium Pyrophosphate Crystal Dissolution Studies
APPENDIX G<br />
Post Doctoral Students<br />
Student Supervisor Thesis Title/Project<br />
Ilyushik, Edward Andrulis, Dr. Irene Identification <strong>and</strong> characterization of genes involved in breast cancer<br />
risk <strong>and</strong> progression<br />
Mejia-Guerrero, Salvador Andrulis, Dr. Irene Gene expression in sarcoma<br />
Mulhall, Cara Andrulis, Dr. Irene Optical spectroscopy of breast tissue, IGF-1 <strong>and</strong> growth hormone in<br />
youth with a family history of breast cancer<br />
Yan, Taiqong Andrulis, Dr. Irene Identification of novel prognostic markers <strong>and</strong> therapeutic targets in<br />
osteosarcoma.<br />
Pethe, Vaijayanti Bapat, Dr. Bharati Methylation studies in colon cancer<br />
Su, Brenda Denomme, Dr. Greg Effect of IVIG on toll-like receptor signaling.<br />
Karakucuk-Koker, Inci Diam<strong>and</strong>is, Dr. Eleftherios Protein Purification Techniques with FPLC <strong>and</strong> HPLC<br />
Kishi, Tadaaki Diam<strong>and</strong>is, Dr. Eleftherios 1. Purification of hK8 from bacclovirus <strong>and</strong> clinical applications. 2.<br />
Purification of hK7 from mammalian cells <strong>and</strong> clinical applications. 3.<br />
Activation of kallikreins<br />
Komatsu, Nahako, Diam<strong>and</strong>is, Dr. Eleftherios Characterization of human kallikreins in skin by immunohistochemistry<br />
Paliouras, Miltiades Diam<strong>and</strong>is, Dr. Eleftherios Investigating the genetic regulation of kallikrein expression.<br />
Moreno, Luisa Grynpas, Dr. Marc Fracture mechanics of bone in animal models<br />
Anderca, Marinela K<strong>and</strong>el, Dr. Rita Role of Sox family of transcription factors in modulating cartilage tissue<br />
formation<br />
DeCroos, Amritha K<strong>and</strong>el, Dr. Rita Cell Signalling in Mechanically Stimulated in vitro grown articular<br />
cartilage<br />
Gan, Lu K<strong>and</strong>el, Dr. Rita Design of Implant for Soft Tissue Attachment<br />
Yang, Liu K<strong>and</strong>el, Dr. Rita Biomaterial design <strong>and</strong> effect on anulus fibrosus tissue formation<br />
Moskovtsev, Sergey Mullen, Dr. Brendan Sperm protamines <strong>and</strong> DNA integrity<br />
Jarzanazi, Hamdi Ozcelik, Dr. Hilmi Trinucleotide repeat expansion in breast cancer<br />
Onay, Venus Ozcelik, Dr. Hilmi Microarray approach to study the genetic polymorphisms in breast<br />
Savas, Sevtap Ozcelik, Dr. Hilmi Study of SNP’s in DNA repair pathway <strong>and</strong> breast cancer risk using DNA<br />
cancer<br />
pooling strategy<br />
Jahanmehr, Hamid Wang, Dr. Chen Computerized imaging analysis of hematopoietic cells<br />
Zheng, Jianing Wang, Dr. Chen Flow cytometry analysis <strong>and</strong> cell sorting <strong>and</strong> characterization of RhoA<br />
mutation in development <strong>and</strong> hematopoiesis
APPENDIX H<br />
Summer Students May – August <strong>2005</strong><br />
Student Supervisor Project Title<br />
Alison Campbell Dr. van der Kwast Expression profiling of human tissue kallikrein 12 in breast <strong>and</strong> ovarian cancer<br />
Cameron Ellis Dr. Keating Acquired in utero brain injury: the spectrum <strong>and</strong> chronicity of disease in unexpected<br />
stillbirths<br />
Jackie Fleischer Dr. Bromberg Identifying the underlying regulatory mechanisms of dysregulated human tissue<br />
kallikrein expression in ovarian cancer cells<br />
Carolyn Goard Dr. Diam<strong>and</strong>is Identification of single nucleotide polymorphisms (SNPs) within the human tissue<br />
kallikrein locus: Functional implications <strong>and</strong> association to disease<br />
Lara Gotha Dr. Leong Molecular characterization of human cord blood progenitors under various<br />
osteogenic conditions<br />
Vincent Ho Dr. Keating Refractile Appearance of Misoprostol following Induction of Labour<br />
Jovil Kanampuza Dr. Pritzker Inhibition of Alkaline Phosphatase by Cysteine Analogue Mercaptopyruvic acid:<br />
Implication for Calcium Pyrophosphate Dihydrate Crystal Deposition Disease<br />
Ilana Kopolovic Dr. Diam<strong>and</strong>is Cloning, expression, <strong>and</strong> purification of proform <strong>and</strong> active form hk3 protein<br />
Natala Kruglyk Dr. Grynpas Bone Mechanical Properties in Knock-Out Mouse Model of Oculodentodigital<br />
Dysplasia<br />
Cynthia Kuk Dr. Hoffman Characterization of newly generated antibodies <strong>and</strong> assessment of their utility as<br />
biomarkers of cancer, an immunohistological approach<br />
Ronald Lai Dr. Wang In Vitro Monitoring of proliferation of CLL (Chronic Lymphocytic Leukemia) cells by<br />
Jonathan Micieli<br />
Stephanie Miller<br />
Dr. Andrulis<br />
Dr. Fern<strong>and</strong>es<br />
Flow Cytometry<br />
Analysis of SOD2 <strong>and</strong> XRCC1 polymorphisms in soft tissue sarcomas<br />
The relationship of antibody titre to fetal anemia in hemolytic disease of the<br />
newborn<br />
Stephanie Neufeld Dr. Grynpas The effects of N-butyryl glucosamine on bone quality in an ovariectomized rat<br />
model<br />
Igal Raizman Dr. K<strong>and</strong>el The differential effects of mechanical stimulation on the zones of articular cartilage<br />
Arbora Resulaj Dr. K<strong>and</strong>el Perfusive culture system for annulus fibrosus tissue growth<br />
Jenny Shu Dr. Denomme Effects of anti-Kell <strong>and</strong> anti- Glycophorin C on K562 <strong>and</strong> Progenitor Cells<br />
Joseph Tota Dr. Andrulis Growth, Diet <strong>and</strong> Genetic Variation <strong>and</strong> Risk of Childhood Osteosarcoma - An<br />
Epidemiologic Study Proposal<br />
William Wong Dr. Winsor Reference St<strong>and</strong>ards <strong>and</strong> Quality Assessment in a Clinical Cytogenetics <strong>Laboratory</strong><br />
Jing Zhang Dr. Vieth The determination of 1,25-dihydroxyvitamin D3 in human prostate tissues
APPENDIX I<br />
<strong>Report</strong>able Tests<br />
Clinical Service Statistics<br />
Tests (MIS) Technical Units (MIS)<br />
SECTION 03/04 04/05 05/06 03/04 04/05 05/06<br />
Histopathology 746,090 798,045 892,268 4,711,093 5,296,038 5,821,490<br />
Cytopathology 265,267 279,878 294,650 908,424 1,035,968 1,063,729<br />
Blood Transfusion Services 224,152 244,254 261,859 772,874 864,621 908,121<br />
Hematopathology 481,551 515,911 516,523 2,077,134 2,253,476 2,254,696<br />
Biochemistry 2,447,160 2,648,992 2,996,655 3,175,541 3,542,836 3,710,675<br />
Patient Services 96,677 109,770 113,728 695,580 792,945 820,090<br />
Cytogenetics 7,342 8,388 10,170 1,494,870 1,608,836 2,083,009<br />
TOTAL 4,286,635 4,605,248 5,085,853 14,004,368 15,414,720 16,661,810<br />
CASES<br />
SECTION 02/03 03/04 04/05 05/06<br />
Surgical <strong>Pathology</strong> 17,990 17,447 18,417 18,861<br />
Cytopathology 26,061 25,747 28,959 30,641<br />
Autopsies 197 193 200 207<br />
Bone Bank 197 167 309 299<br />
Stone <strong>and</strong> Crystal Analysis 1,500 1,466 1,698 1,817<br />
<strong>Report</strong>able Tests<br />
2003/04 Yr/Yr 2004/05 Yr/Yr <strong>2005</strong>/06 Yr/Yr<br />
MSH In-Patients 908,173 2% 959,504 6% 966,465 1%<br />
MSH Out-Patients 1,103,338 -3% 1,262,696 14% 1,294,479 2%<br />
Referred-In 214,207 21% 210,623 -2% 232,306 10%<br />
Total 2,225,718 1% 2,444,559 10% 2,493,250 2%
APPENDIX I (con’t)<br />
<strong>Report</strong>able Tests<br />
<strong>Pathology</strong> And <strong>Laboratory</strong> <strong>Medicine</strong>:<br />
Technical And Support Staff F.t.e.<br />
2002/03 2003/04 2004/05 <strong>2005</strong>/06<br />
Administrative Director 1 1 1 1<br />
Manager 4 5 5 5<br />
Administrative Support 2 2 2 2<br />
Information Systems Support 2 2 3 3<br />
Technologists 118.82 127.12 131.2 131.2<br />
Technicians 33.4 38.5 46.17 46.17<br />
Secretaries<br />
Administrative Support 2 2 2 2<br />
Medical/Scientific<br />
Administrative Support<br />
9 9 6 6<br />
<strong>Report</strong>ing clerk/dicta-typists 5 5 5.73 5.73<br />
Pathologist Assistant 3.8 3.8 4 4<br />
Morgue Attendant 1 1 1 1<br />
Nurse 1 1 1 1<br />
Receptionists 1.28 1.28 1.28 1.28<br />
TOTAL 184.3 198.7 209.38 209.38
APPENDIX J<br />
External Service Linkages<br />
General <strong>Laboratory</strong> Service<br />
• Hospitals In-Common <strong>Laboratory</strong> - selected biochemistry services<br />
• The Baycrest Centre for Geriatric Care - microbiology, pathology, cytopathology, selected hematopathology, biochemistry<br />
<strong>and</strong> Holter monitor services<br />
• Toronto Rehabilitation Institute (all sites) - comprehensive laboratory, phlebotomy <strong>and</strong> electrocardiograph services<br />
• Centre for Addiction <strong>and</strong> Mental Health (all sites)<br />
• Humber River Regional Hospital (all sites)<br />
selected laboratory services<br />
• Lakeridge Health System<br />
selected laboratory services<br />
• Midwives Collectives of Toronto<br />
• Selected specialized laboratory services for many hospitals throughout Ontario.<br />
Clinical Trials Services<br />
Independent investigators <strong>and</strong> corporations.<br />
Preclinical Research <strong>and</strong> Development Services<br />
For corporations in Canada, the United States <strong>and</strong> Europe.
APPENDIX K<br />
April <strong>2006</strong> Departmental Rounds<br />
PATHOLOGY AND LABORATORY MEDICINE ROUNDS – April 03-07, <strong>2006</strong><br />
TIME Monday Tuesday Wednesday Thursday Friday<br />
7:30 AM Gyne Path<br />
Room 663<br />
8:00 AM Drs.Colgan/Chapman<br />
8:30 AM Gross Conference Gross Conference<br />
Grossing Room<br />
Gross Conference Gross Conference Staff Micro<br />
Conference<br />
Grossing Room Grossing Room Grossing Room (R. K<strong>and</strong>el)<br />
9:00 AM (M. Curtis) Multi-header<br />
9:30 AM<br />
10:00 AM<br />
11:00 AM<br />
12:00 PM * note below<br />
01:00 PM<br />
02:00 PM Interesting &<br />
02:30 PM<br />
03:00 PM<br />
03:30 PM<br />
04:00 PM Dr. R.<br />
K<strong>and</strong>el<br />
Sarcoma<br />
Rounds<br />
04:30 PM 5th floor<br />
Radiology<br />
Gyne<br />
Tumour<br />
Breast Tumour Board<br />
The Group Room-12th<br />
05:00 PM Board IBD Rounds GI/GI Surgery Rounds<br />
- PMH<br />
14th flr.<br />
Classroom<br />
floor<br />
Dr. F. O’Malley<br />
14th floor classroom<br />
05:30 PM Dr. R. Riddell Dr. R. Riddell<br />
06:00 PM<br />
Classical<br />
Case Rounds<br />
Room 663.<br />
(R. Kirsch)<br />
Room
APPENDIX K<br />
April <strong>2006</strong> Departmental Rounds<br />
PATHOLOGY AND LABORATORY MEDICINE ROUNDS – April 10-14, <strong>2006</strong><br />
TIME Monday Tuesday Wednesday Thursday Friday<br />
7:30 AM Gyne Path<br />
Room 663<br />
Drs.Colgan/<br />
Chapman<br />
8:00 AM D<br />
8:30 AM Gross Conference Gross<br />
Grossing Room Conference Grossing Room Grossing Room F<br />
9:00 AM Grossing (M. Curtis) R<br />
Room<br />
Gross Conference Gross Conference<br />
9:30 AM I<br />
10:00 AM D<br />
11:00 AM A<br />
12:00 PM * note below Y<br />
01:00 PM<br />
02:00 PM Interesting & Classical<br />
02:30 PM<br />
03:00 PM<br />
03:30 PM<br />
04:00 PM Dr. R.<br />
K<strong>and</strong>el<br />
Sarcoma<br />
Rounds<br />
04:30 PM 5th floor<br />
Radiology<br />
Gyne<br />
Tumour<br />
05:00 PM Board IBD<br />
- PMH<br />
Rounds<br />
05:30 PM Dr. R.<br />
06:00 PM<br />
Breast Tumour Board<br />
The Group Room-12th<br />
floor<br />
Dr. F. O’Malley<br />
GI/GI Surgery Rounds<br />
14th flr. 14th floor classroom<br />
Riddell<br />
Dr. R. Riddell<br />
Case Rounds<br />
Room 663.<br />
(A.M. O’Shea)<br />
G<br />
O<br />
O
APPENDIX K<br />
April <strong>2006</strong> Departmental Rounds<br />
PATHOLOGY AND LABORATORY MEDICINE ROUNDS – April 17-21, <strong>2006</strong><br />
TIME Monday Tuesday Wednesday Thursday Friday<br />
7:30 AM Gyne Path<br />
8:00 AM<br />
Room 663<br />
Drs.Colgan/Chapman<br />
8:30 AM Gross Conference<br />
Grossing Room<br />
Gross Conference Gross Conference Staff Micro Conference<br />
E (M. Curtis) Grossing Room Grossing Room (F. O’Malley)<br />
9:00 AM A Multi-header Room<br />
9:30 AM S<br />
10:00 AM T<br />
11:00 AM E<br />
12:00 PM R<br />
01:00 PM<br />
02:00 PM Interesting & Classical<br />
M Case Rounds<br />
O Room 663.<br />
02:30 PM N (M. Curtis)<br />
03:00 PM D<br />
03:30 PM A<br />
04:00 PM Y Breast Tumour Board<br />
The Group Room-<br />
12th floor<br />
04:30 PM Dr. F. O’Malley<br />
05:00 PM GI/GI Surgery Rounds<br />
14th floor classroom<br />
05:30 PM Dr. R. Riddell
APPENDIX K<br />
April <strong>2006</strong> Departmental Rounds<br />
PATHOLOGY AND LABORATORY MEDICINE ROUNDS – April 24-28, <strong>2006</strong><br />
TIME Monday Tuesday Wednesday Thursday Friday<br />
7:30 AM Gyne Path<br />
Room 663<br />
8:00 AM Drs.Colgan/<br />
Chapman<br />
8:30 AM Gross Conference Gross<br />
Conference<br />
Gross Conference Gross Conference Staff Micro<br />
Conference<br />
Grossing Room Grossing Room Grossing Room Grossing Room (M. Curtis)<br />
9:00 AM (M. Curtis) Multi-header<br />
9:30 AM<br />
10:00 AM<br />
11:00 AM<br />
12:00 PM * note below<br />
01:00 PM<br />
02:00 PM Interesting &<br />
02:30 PM Prof. O. Kallioniemi: “Microarray Technology in Cancer”<br />
03:00 PM<br />
03:30 PM<br />
Workshop for <strong>Pathology</strong> Residents & Graduate Students<br />
18th floor Auditorium<br />
04:00 PM Dr. R.<br />
K<strong>and</strong>el<br />
Sarcoma<br />
Rounds<br />
04:30 PM 5th floor<br />
05:00 PM Harold G.<br />
Pritzker<br />
Memorial<br />
Lecture<br />
Prof. O.<br />
Kallioniemi:<br />
“Translational<br />
Cancer<br />
Systems<br />
Biology”<br />
05:30 PM 18th floor<br />
06:00 PM<br />
Auditorium<br />
Radiology<br />
Gyne<br />
Tumour<br />
Board<br />
- PMH<br />
Breast Tumour<br />
Board<br />
The Group Room-<br />
12th floor<br />
Dr. F. O’Malley<br />
IBD Rounds GI/GI Surgery<br />
14th flr.<br />
Classroom<br />
Rounds<br />
14th floor<br />
classroom<br />
Dr. R. Riddell Dr. R. Riddell<br />
Classical<br />
Case Rounds<br />
Room 663.<br />
(M. Curtis)<br />
Room
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600 University Avenue<br />
Toronto, Ontario, Canada M5G 1X5