1 1. Person Name Stein First name Jens Volker Titel Ph. D ...

1. Person
Name Stein
First name Jens Volker
Titel Ph. D.
Citizenship German
Curriculum vitae Jens Stein
Date and Place of birth 12.11.1968 in Aachen (Germany)
Present address University of Bern
Theodor Kocher Institute
Freiestr. 1
3012 Bern/ Switzerland
Tel. (+ 41) 31 631 5390
Fax. (+ 41) 31 631 3799
e-mail: jstein@tki.unibe.ch
www.tki.unibe.ch/stein.htm
2. Academic career
Since 07/2010 Lecturer (“Dozent”), Theodor Kocher Institute, University of Bern,
Switzerland
2004 – 2010 Group leader (“Oberassistent”), Theodor Kocher Institute, University of
Bern, Switzerland; Venia docendi in Immunology (April 2010)
2003 – 2004 Young Investigator “Ramón y Cajal”, Department of Immunology and
Oncology, National Center for Biotechnology (CNB)-CSIC, Madrid, Spain
1999 – 2003 Postdoctoral fellow in the laboratory of Carlos Martínez-A., Department of
Immunology and Oncology, National Center for Biotechnology (CNB)-
CSIC, Madrid, Spain
1999 Ph.D. awarded from the Université Louis Pasteur, Strasbourg, France
Mention “Très honorable avec félicitations”
1995 –1999 Ph. D. thesis at the Center for Blood Research (CBR) and Department of
Pathology, Harvard Medical School (HMS), Boston, USA and Institut de
Génétique et Biologie Moléculaire et Cellulaire (IGBMC), University Louis
Pasteur, Strasbourg, France
Title: “Mechanisms of lymphocyte homing to peripheral lymph nodes”
Supervisors: Dr. U. H. von Andrian, CBR and HMS, and Dr. Diane
Mathis, IGBMC, University Louis Pasteur, France
1995 Diploma in Molecular Biology and Bioengineering awarded from Ecole
Supérieure de Biotechnologie de Strasbourg (ESBS), University Louis
Pasteur, Strasbourg, France
1995 Diploma thesis at LeukoSite Inc., Cambridge, USA
Title: “A11: A new chemokine receptor & CC-CKR-1: Functional
characterization”
Supervisor: Dr. C. R. Mackay, LeukoSite, Inc., Cambridge, USA
1992 – 1995 Ecole Supérieure de Biotechnologie de Strasbourg (ESBS),
University Louis Pasteur, Strasbourg, France
1989 – 1992 Basic biology studies (“Vordipom”), University of Karlsruhe, Germany
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3. Awards
Curriculum vitae Jens Stein
2007 Novartis Foundation grant (beneficiary Dr. Varsha Kumar)
2005 – 2006 Roche Research Foundation grant (beneficiary Dr. Inga Potapova)
2003 – 2004 “Ramón y Cajal” Young Investigator fellowship
2000 – 2003 Human Frontiers Science Program long-term fellowship
1999 – 2000 EMBO long-term fellowship
4. Financial support for the laboratory
2011 – 2014 Swiss National Foundation Research grant “Investigating the molecular
factors controlling lymphocyte motility and activation by in vivo imaging”
2011 – 2014 Marie Curie European Reintegration grant ” 2PM T cell Imaging”
2009 – 2012 Sinergia grant "Examining the function of lymphoid organ structure during
antiviral immune responses using microscopic and mesoscopic imaging"
2009 – 2012 UBS Optimus foundation “Visualizing host-pathogen interactions during
dengue virus infection”
2008 – 2011 Swiss National Foundation Research grant “In vivo analysis of
intracellular signaling pathways during lymphocyte trafficking and
activation”
2006 –2010 Marie Curie Excellence grant “Combining multi-photon microscopy and
quantum dot technology to study molecular dynamics on single cells in
vivo”
2006 – 2008 Participation in EU 6 th Framework program Integrated project “Molecular
Imaging”
2005 – 2008 Swiss National Foundation Research grant “Intracellular signaling
pathways during lymphocyte trafficking”
5. Memberships, additional activities
Since 2002 Reviewer for J Leukocyte Biology, J Exp Med, Immunity, Blood…
Since 2004 Member of Spanish Society for Molecular Biology (SEBBM)
Since 2006 Member of German Society for Immunology (DGfI)
Since 2007 Reviewer for EU FP7 projects
Since 2008 Member of F1000 Life Science Faculty
6. Laboratory members
Current: Dr. Fernanda Matos Coelho, Dr. Federica Moalli, Renzo Danuser (Ph. D. student), Miroslav Hons (Ph. D.
Student), Markus Pieczyk (Ph. D. Student)
Former: Dr. Varsha Kumar, Dr. César Nombela-Arrieta (Ph. D. student), Dr. Kathrin Gollmer (Ph. D. student), Dr. Inga
Potapova, Dr. Silvia F. Soriano, Dr. Daniela Natale, Pascal Halbherr (Master student)
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Curriculum vitae Jens Stein
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7. Publication list 2004 - 2010
Complete publication list: http://www.tki.unibe.ch/stein.htm
Curriculum vitae Jens Stein
Original manuscripts (corresponding authorship marked with *)
Critical roles for Rac GTPases in T cell migration to and within lymph nodes. Faroudi M, Hons M, Zachacz A, Dumont
C, Lyck R, Stein JV, Tybulewicz VLJ. Blood, prepublished online September 24, 2010; DOI 10.1182/blood-2010-08-
299438.
Redundant and non-redundant roles for stromally expressed Ig superfamily members during lymphocyte recirculation.
Boscacci RT, Deutsch U, Pfeiffer F, Gollmer K, Checa Sevilla AI, Soriano SF, Natale D, Henrickson S, von Andrian
UH, Fukui Y, Mellado M, Engelhardt B, Stein JV*. Blood. 2010 Aug 12;116(6):915-25. Epub 2010 Apr 15.
Mesoscopic analysis of B cell/lymphotoxin-dependent global lymphoid tissue remodeling during viral infection. Kumar
V, Scandella E, Danuser R, Onder L, Fukui Y, Ludewig B, Stein, JV*. Blood. 2010 Jun 10;115(23):4725-33. Epub
2010 Feb 25.
CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway. Gollmer K, Asperti-Boursin F,
Tanaka Y, Okkenhaug K, Vanhaesebroeck B, Peterson JR, Fukui Y, Donnadieu E, Stein JV*. Blood. 2009 Jul
16;114(3):580-8. Epub 2009 May 18.
Statins induce regulatory T cell recruitment via a CCL1 dependent pathway. Mira E, León B, Barber DF, Jiménez-
Baranda S, Goya I, Almonacid L, Márquez G, Zaballos A, Martínez-A C, Stein JV, Ardavín C, Mañes S. J Immunol.
2008 Sep 1;181(5):3524-34.
Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific
functional barriers within the peripheral lymph node. Pfeiffer F, Kumar V, Butz S, Vestweber D, Imhof BA, Stein JV,
Engelhardt B. Eur J Immunol. 2008 Aug;38(8):2142-55.
L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells.
Guarda G, Hons M, Soriano SF, Huang AY, Polley R, Martín-Fontecha A, Stein JV, Germain RN, Lanzavecchia A,
Sallusto F. Nat Immunol. 2007 Jul;8(7):743-52. Epub 2007 May 27.
A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress.
Nombela-Arrieta C, Mempel TR, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martínez-A C, Fukui Y, von Andrian UH,
Stein JV*. J Exp Med. 2007 Mar 19;204(3):497-510. Epub 2007 Feb 26.
DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the
integrin alpha4beta1. García-Bernal D, Sotillo-Mallo E, Nombela-Arrieta C, Samaniego R, Fukui Y, Stein JV, Teixidó
J. J Immunol. 2006 Oct 15;177(8):5215-25.
Opioids trigger alpha 5 beta 1 integrin-mediated monocyte adhesion. Pello OM, Duthey B, García-Bernal D,
Rodríguez-Frade JM, Stein JV, Teixido J, Martínez C, Mellado M. J Immunol. 2006 Feb 1;176(3):1675-85.
Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1. García-
Bernal D, Wright N, Sotillo-Mallo E, Nombela-Arrieta C, Stein JV, Bustelo XR, Teixidó J. Mol Biol Cell. 2005
Jul;16(7):3223-35. Epub 2005 May 4.
Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing.
Nombela-Arrieta C, Lacalle RA, Montoya MC, Kunisaki Y, Megías D, Marqués M, Carrera AC, Mañes S, Fukui Y,
Martínez-A C, Stein JV*. Immunity. 2004 Sep;21(3):429-41.
CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph
nodes. Scimone ML, Felbinger TW, Mazo IB, Stein JV, Von Andrian UH, Weninger W. J Exp Med. 2004 Apr
19;199(8):1113-20.
Reviews and comments
How to be naive. Stein JV*. Immunity. 2009 Jul 17;31(1):9-11.
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Curriculum vitae Jens Stein
Close encounters of the 3D kind. Stein JV*. Blood. 2009 Jun 4;113(23):5698-9.
How chemokines invite leukocytes to dance. Thelen M, Stein JV*. Nat Immunol. 2008 Sep;9(9):953-9.
Chemokine control of lymphocyte trafficking: a general overview. Stein JV*, Nombela-Arrieta C. Immunology. 2005
Sep;116(1):1-12.
Book chapter:
Development of lymph node circulation and homing mechanisms. Ager A, Coles MC, Stein JV*. 2010. In
Developmental Biology of Peripheral Lymphoid Organs, Springer (Editor: P. Balogh). In press
Intravital microscopy and in vitro flow chamber: Techniques to study leukocyte adhesion under flow and in real time.
Stein JV*. 2005. In Leukocyte Trafficking, Wiley-VCH (Editors: A. Hamann and B. Engelhardt).
Bern, March 2011
Jens Stein
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