Synthesis of Morphine Alkaloids
Synthesis of Morphine Alkaloids
Synthesis of Morphine Alkaloids
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Structure<br />
N<br />
B<br />
A<br />
D<br />
C<br />
<strong>Morphine</strong><br />
O<br />
E<br />
<strong>Synthesis</strong><br />
OH<br />
HO<br />
Introduction<br />
O<br />
H<br />
HO<br />
3<br />
4<br />
5<br />
6<br />
12<br />
2<br />
13<br />
14<br />
7<br />
1<br />
11<br />
15<br />
10<br />
16<br />
• Landmark synthesis was in 1952 by Gates<br />
8<br />
9<br />
H<br />
N<br />
Me<br />
Key Features: 5 rings, 5<br />
contiguous stereocenters,<br />
compact array <strong>of</strong> functionality<br />
• Since then at least 18 more total and formal synthesis<br />
<strong>of</strong> <strong>Morphine</strong> have appeared<br />
• This overview will encompass 6 unique routes
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