Download 2005Programm.pdf - DGNN

05. Oktober 2005 

Begrüßung 

13:00 Begrüßung der Teilnehmer 

Neuromuskulärer Workshop 

Moderation: A. Bornemann, H.H. Goebel 

13:30 Beginn der Vorträge 

Programm 

50. Jahrestagung der DGNN 

Klinische Neuropathologie - STATE OF THE ART - 

Muskeldystrophien A. Bornemann 

Entzündliche Myopathien W. Schulz-Schaeffer 

Neurogene Muskelatrophien J. Weis 

Mitochondrial Myopathies H. Vogel 

Pause 

Diverse Fallpräsentationen 

19:30 Ende der Vorträge 

Abendprogramm 

20:00 Empfang in der Grazer Burg bei Frau 

Landeshauptmann W. Klasnic


Eröffnung 

09:00 Offizielle Eröffnung der Tagung 

Tagungsprogramm 

Vorsitz: R. Kleinert, G.F. Walter 

Programm 



09:30 - 10:15 "Historie der DGNN" - zur 50. Jahrestagung H. Mennel 

10:30 - 11:00 Pause 

11:00 - 12:15 Molekulare Neuroanatomie- Grundlage für das 

Verständnis normaler Funktion und pathologische 

Veränderungen des Nervensystems 

12:30 - 14:00 Mittagspause 

Vorsitz: R. Schober, J.M. Schröder 

14:00 - 15:15 Moderne Diagnostik entzündlicher Erkrankungen 

des Zentralnervensystems 

15:30 - 16:00 Pause 

16:00 - 17:00 Poster Session I: PA1-3, PB1-15 

(Entzündung/Immunologie, Degeneration) 

Vorsitz: H. Budka, M. Deckert 

17:00 - 18:00 Vorträge: VA1-5 

(Entzündung/Immunologie) 

18:00 - 18:30 Pause 

18:30 – 21:00 Mitgliederversammlung der DGNN/ lokales Buffet 

M. Frotscher 

H. Budka



Vorsitz: K. Jellinger, H. Kretzschmar 

09:00 - 10:00 Kurt Jellinger Prize Lecture 

Cortical Neurogenesis and Thanatophoric 

Dysplasia: More isn't better. 

10:00 - 10:30 Pause 

10:30 - 11:15 Moderne Diagnostik neurodegenerativer 

Erkrankungen des Zentralnervensystems 

Vorsitz: I. Blümcke, W. Brück 

11:30 - 13:00 Vorträge: VB1-9 

(Degeneration) 

13:00 - 14:30 Mittagspause 

14:30 - 18:00 Poster Session II: PD1-17 

(Freie Themen, Muskel/Nerv) 

Vorsitz: H.H. Goebel, G. Stoltenburg-Didinger 

14:30 - 16:30 Vorträge: VB10-12, VD1-9 

(Forts. Degeneration, Freie Themen, 

Muskel/Nerv) 

16:30 - 17:00 Pause 

Vorsitz: W. Feiden, K.H. Plate 

17:00 - 18:00 Vorträge: VC1-6 

(Onkologie I) 

Abendprogramm 

ab 19:00 Gesellschaftsabend 

Programm 



R.F. Hevner 

University of 

Washington, Seattle, 

WA, USA 

H. Kretzschmar



Vorsitz: W. Paulus, H. Mennel 

09:00 - 09:45 Moderne Tumordiagnostik in der 

Neuroonkologie 

10:00 - 10:30 Pause 

10:30 - 12:30 Poster Session III: PC1-15 

(Onkologie) 

Vorsitz: G. Reifenberger, J.A. Hainfellner 

11:00 - 13:30 Vorträge: VC7-15 

(Onkologie II) 

Tagungsende 

13:30 - 14:00 Schlußworte - Ende der Tagung 

Programm 



G. Reifenberger

Posterpräsentationen 

Themenkreise A- D 

A: Entzündung + Immunologie 

B: Degeneration + Epilepsie 

C: Onkologie 

D: Freie Themen + Muskel/Nerv 

A: Entzündung + Immunologie, Posterpräsentationen 

P/A1 Regression of synapses in the cerebellar dentate nucleus of patients with 

multiple sclerosis 

Albert M 1 , Antel J 2 , Prineas JA 3 , Palkovits M 4 , Wolff JR 5 , Brück W 1 , Stadelmann C 1 

1 Department of Neuropathology, Georg August University Goettingen, Germany, 2 Department of 

Neurology and Neurosurgery, McGill University Montreal, Canada, 3 Institute of Clinical Neurosciences, 

Department of Medicine, University of Sydney, Australia, 4 Department of Anatomy, Histology and 

Embryology, Semmelweis University Budapest, Hungary, 5 Center of Anatomy, Georg August University 

Goettingen, Germany 

P/A2 Transgenic expression of TIMP 1 in the CNS recruits lymphocytes and prolongs 

clinical symptoms in EAE 

Dea Humar, Axel Pagenstecher 

Dept. Neuropathology, University of Freiburg 

P/A3 Influences of Activated Microglia on the Membrane Resting Potential and the 

Gap Junction Communication of an Astroglial Cell Line 

Caroline Möller, Aiden Haghikia, Katharina Heupel, Daniel Hinkerohe, Dirk Smikalla, Dominika 

Szlachta, Rolf Dermietzel and Pedro M. Faustmann 

Abteilung für Neuroanatomie und Molekulare Hirnforschung, Ruhr-Universität Bochum, 44780 Bochum, 

Deutschland

B: Degeneration + Epilepsie, Posterpräsentationen 

P/B1 Olfactory pathology in aging and Alzheimer disease 

Johannes Attems, Kurt A. Jellinger, Felix Lintner 

Institute of Clinical Neurobiology, A-1070 Vienna, Austria 

P/B2 Neuropathologisches Epilepsie-Register: Update 2005 

I. Blümcke 

Universität Erlangen, Neuropathologie, 91054 Erlangen 

P/B3 Spinocerebellar ataxias (SCA): evidence for microglial activation 

K. Bürk 1 , M. Mittelbronn 1 , R. de Vos 2 , J. Büttner-Ennever 3 , R. Rüb 4 , M. Meyermann 1 , H. 

Schluesener 1 

1 Institute of Brain Research, University of Tübingen, Tübingen, Germany, 2 Laboratorium Pathologie Oost 

Nederland, Enschede, The Netherlands, 3 Institute of Anatomy, Ludwig-Maximilians-University, Munich, 

Germany, 4 Institute of Clinical Neuroanatomy, University of Frankfurt, Frankfurt, Germany 

P/B4 Expression profiling analysis in epilepsy-associated gangliogliomas 

Jana Fassunke, Volker Schick, Achim Tresch, Phillip Koch, Claudia Ullmann, Christian E Elger, 

Johannes Schramm, Albert J Becker 

Universitätsklinik Bonn, Institut für Neuropathologie, 53105 Bonn, Deutschland 

P/B5 Supratentorial tanycytic ependymoma associated with childhood epilepsy – 

report of three cases 

Volkmar H. Hans 1 , Raffael Villagrán 1 , Markus Bergmann 3 , Ingrid E. Tuxhorn 2 , Friedrich G. 

Wörmann 2 , Heinz W. Pannek 2 

1 Institut für Neuropathologie and 2 Epilepsie-Zentrum Bethel, Evangelisches Krankenhaus Bielefeld, D- 

33617 Bielefeld, 3 Institut für Neuropathologie, Klinikum Bremen-Ost, D-28325 Bremen 

P/B6 Volumetric and neuropathological examination reveals hemispheric hypoplasia 

in children with severe epilepsy and focal cortical dysplasia type I 

M. Hildebrandt, T. Pieper, P. Winkler, D. Kolodziejczyk, H. Holthausen; I. Blümcke 

FAU Erlangen, Lehrstuhl für Neuropathologie, 91054 Erlangen, Deutschland 

P/B7 Tau and alpha-synuclein brainstem pathology in Alzheimer disease 

Kurt A. Jellinger, Johannes Attems 

Institute of Clinical Neurobiology, A-1070 Vienna, Austria 

P/B8 Alpha2-macroglobulin (A2M) and neutrophil elastase (NE) differently 

participate in the evolution of atherosclerotic plaques in the circle of Willis 

S. Larionov 1 , O. Dedeck 1 , G. Birkenmeier 2 , M. Orantes 3 , D.R. Thal 1 

1 Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany, 2 Department of 

Biochemistry, University of Leipzig, Leipzig, Germany, 3 Department of Pathology, Municipal Hospital 

Offenbach, Offenbach am Main, Germany

P/B9 Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) 

molecules in epilepsy associated glioneuronal lesions 

Michael Majores 1 , Volker Schick 1 , Gudrun Engels 1 , Jana Fassunke 1 , Christian E. Elger 2 , Johannes 

Schramm 3 , Ingmar Blümcke 4 , Albert J. Becker 1 

Depts. of 1 Neuropathology, 2 Epileptology and 3 Neurosurgery, University of Bonn Medical Center, Bonn, 

Germany, 4 Dept. of Neuropathology and Neuropathological Reference Center for Epilepsy Surgery, 

Erlangen Univ., Erlangen, Germany 

P/B10 The role of TM9SF1 and TMEFF1 in an experimental model of Parkinson's 

disease 

Frauke Neff, Anne Wiegand & Jürgen Schlegel 

Neuropathologie, Inst. für Pathologie, TU München, 81675 München, Bayern 

P/B11 Alzheimer-type neuropathology in a 28-year old patient with iatrogenic 

Creutzfeldt-Jakob disease after dural grafting 

Matthias Preusser 1 , Thomas Ströbel 1 , Ellen Gelpi 1,2 , Meinhard Eiler 3 , Gregor Broessner 4 , Erich 

Schmutzhard 4 , Herbert Budka 1,2 

1 Institute of Neurology, Medical University Vienna, Austria, 2 Austrian Reference Centre for Human Prion 

Diseases (OERPE), General Hospital Vienna, Austria, 3 Department of Neurology, LKH Rankweil, Austria, 

4 Department of Neurology, Medical University Innsbruck, Austria 

P/B12 The interferon type I induced protease UBP43 is crucial for CNS myelination 

Jenni Raasch 1 , Ivan Horak 2 , Wolfgang Brück 1 , Klaus-Peter Knobeloch 2 and Marco Prinz 1 

1 Department of Neuropathology, Georg August University, 37075 Göttingen, Germany, 2 Department of 

Molecular Genetics, Institute of Molecular Pharmacology, D-12207 Berlin, Germany 

P/B13 Association of a common COL9A2 polymorphism with recurrent lumbar disc 

disease 

Reinke, A., Knöringer, M., Trappe, A.E., Schlegel, J. 

Technische Universität München, Klinikum r. d. Isar, Institut f. allg. Pathologie, Neuropathologie, 81675 

München, Germany 

P/B14 Cerebrovascular P-glycoprotein expression is decreased in Creutzfeldt-Jakob 

disease 

Silke Vogelgesang, Markus Glatzel, Lary C. Walker, Heyo K. Kroemer, Adriano Aguzzi, Rolf W. 

Warzok 

Universität Greifswald, Department of Neuropathology, 17487 Greifswald, Deutschland 

P/B15 Differential expression of several S100 proteins during experimental 

autoimmune encephalomyelitis 

Karina Wolter 1 , Wolfgang Brück 1 , Günter Fritz 2 and Marco Prinz 2 

1 Department of Neuropathology, Georg August University, D-37075 Göttingen, Germany, 2 Department of 

Biology, University-Konstanz, D-78457 Konstanz, Germany

C: Onkologie, Posterpräsentationen 

P/C1 A novel bispecific small molecule tyrosine kinase inhibitor enhances the effects 

of an experimental radiotherapy in human malignant glioma cells 

S. Berezowska 1 , A. Grosu 2 and J. Schlegel 1 

1 2 

Division of Neuropathology, TU München and GSF-Forschungszentrum Neuherberg, Department of 

Radiotherapy, TU München 

P/C2 Common mutations of b-catenin in adamantinomatous craniopharyngiomas but 

not in other tumours originating from the sellar region 

Rolf Buslei, Michael Nolde, Bernd Hofmann, Stephan Meissner, Ilker Y. Eyupoglu, Florian 

Siebzehnrübl, Eric Hahnen, Jürgen Kreutzer, Rudolf Fahlbusch 

Friedrich-Alexander-Universität Erlangen-Nürnberg, Lehrstuhl für Neuropathologie, 91054 Erlangen, 

Deutschland 

P/C3 Statins induce neuronal differentiation of neuroblastoma cells via activation of 

EGFR 

M.E. Evangelopoulos, J. Weis, A. Krüttgen 

Universitätsklinik RWTH Aachen, Institut für Neuropathologie, 52074 Aachen, Deutschland 

P/C4 Prognostic implications of atypical histological features in choroid plexus 

papilloma 

Astrid Jeibmann, Martin Hasselblatt & Werner Paulus 

Institute of Neuropathology, University Hospital Münster, Germany 

P/C5 Genetic alteration and aberrant expression of the phosphoinositol-3kinase/Akt 

pathway genes PIK3CA and PIKE in glioblastomas 

C. B. Knobbe, A. Trampe-Kieslich and G. Reifenberger 

Department of Neuropathology, Heinrich-Heine-University, Düsseldorf, Germany 

P/C6 Granular cell tumor of the infundibulum with follicular lymphatic hyperplasia – 

case report 

S. Loeser 1 , M. Scholz 2 , R. Pawaresch 3 , G. Reifenberger 1 

1 Institut für Neuropathologie, Heinrich-Heine-Universität, Düsseldorf, 2 Neurochirurgische Klinik, 

Knappschaftskrankenhaus, Ruhr-Universität, Bochum, 3 Institut für Hämatopathologie, Universität Kiel, 

Kiel, Germany 

P/C7 Prognostic value of MGMT promoter hypermethylation, TP53 mutation, MDM2, 

EGFR and CDK4 amplification in malignant glioma patients 

S. Loeser 1 , C. Luyken 2 , , B. Blaschke 1 , S. Köhler 2 , A. Kreuzmann 2 , S. Seghrouchni 2 , 

G. Reifenberger 1 , M. Sabel 2 

Departments of 1 Neuropathology and 2 Neurosurgery, Heinrich-Heine-University, Düsseldorf, Germany

P/C8 Elevated HLA-E levels in grade IV but not in grade II and III human glioma 

correlate with infiltrating CD8+ cytotoxic/NK-cells 

M. Mittelbronn 1 , B. Bunz 1 , P. Harter 1 , H. Schlaszus 1 , A. Schleich 1 , D. Capper 1 , B. Goeppert 1 , R. 

Meyermann 1 , J. Wischhusen 2 , P. Simon 3 

1 Institute of Brain Research, University of Tuebingen, Germany, 2 Interdisciplinary Centre for Clinical 

Research, Department of Gynecology, University of Wuerzburg, Germany, 3 Department of Sports 

Medicine, University of Tuebingen, Germany 

P/C9 Molecular genetic alterations detected in a myxopapillary ependymoma with 

malignant transformation 

Camelia-Maria Monoranu, Inna Lukashova-v. Zangen, Giles Hamilton Vince and Wolfgang 

Roggendorf 

Abteilung für Neuropathologie, Pathologisches Institut- Universität Würzburg, 97080 Würzburg, 

Deutschland 

P/C10 Molecular mechanisms of oxygen sensing in malignant brain tumors - Pro- and 

antitumorigenic effects 

J Riedel, J. Landgraf, D. Sommerlad, K.H. Plate, T. Acker 

Neurologisches Institut (Edinger-Institut), 60528 Frankfurt am Main, Deutschland 

P/C11 Germinoma: Unusual radiographic and pathologic presentation in two patients 

Elisabeth J. Rushing, M.D., Glenn D. Sandberg, M.D., Alexander R. Judkins, M.D., Gilbert Vezina, 

M.D., Nadja Kadom, M.D., John S. Myseros, M.D , Roger Packer, M.D, Mariarita Santi, M.D. 

Armed Forces Institute of Pathology, 20306-6000 Washington, DC, USA 

P/C12 FZD9 Expression in Primitive Neuroectodermal Tumours 

J. Schittenhelm, Z. Zhang, K. Trautmann, J.R. Iglesias-Rozas, R. Meyermann, H.J. Schlüsener 

Universität Tübingen, Institut für Hirnforschung, 72076 Tübingen, Deutschland 

P/C13 The tumor-brain border of invasive meningiomas 

Jens Schittenhelm, Jasmin Fritz, Florian Roser, Marcos Tatagiba, Christian Mawrin, Antje 

Bornemann 

Institut für Hirnforschung, D-72076 Tübingen 

P/C14 N-Myc downstream-regulated gene 2 (NDRG2) frequently shows reduced 

expression and promoter hypermethylation in human glioblastomas 

Martin Tepel, Marietta Wolter, Peter Roerig, Guido Reifenberger 

Institut für Neuropathologie, Heinrich-Heine-Universität Düsseldorf, Germany 

P/C15 Expression pattern of frizzled 9 in human astrocytomas 

Zhiren Zhang, Jens Schittenhelm, Ketai Guo, H.J. Buhring, Katrin Trautmann, Richard Meyermann, 

and Hermann J. Schluesener 

Institute of Brain Research, 72076 Tuebingen

D: Freie Themen + Muskel/Nerv, Posterpräsentationen 

P/D1 Digital virtual microscopy - a new method in diagnostics und education 

Silvia Feiden, Wolfgang Feiden 

Universitätsklinikum des Saarlandes, Inst. für Neuropathologie, D - 66421 Homburg, Deutschland 

P/D2 Repeated Lipopolysaccharide Administration Induces Hyperalgesic Tolerance, 

but Enhances Glial Activation in Rat Spinal Cord 

Liang-Hao Guo, Katrin Trautmann, Hermann J. Schluesener 

Eberhard Karls Universität Tübingen, Institut für Hirnforschung, D-72076 Tübingen 

P/D3 Multimodal impact of DCC and Netrin-1 on human fetal brain stem development 

P. Harter, B. Bunz, H. Schlaszus, R. Meyermann, M. Mittelbronn 

Institute of Brain Research, University of Tuebingen, Germany 

P/D4 Granulocyte-Colony Stimulating Factor (G-CSF) reduces infarct volume upon 

delayed application in middle cerebral artery occlusion in rats and is expressed along 

with neuronal G-CSF receptors upon acute ischemic stroke in the human brain 

Martin Hasselblatt, Armin Schneider & Wolf-Rüdiger Schäbitz 

Universitätsklinikum Münster, Institut für Neuropathologie, 48149 Münster, Deutschland 

P/D5 Characterisation of neuroblast-dissemination in the injured and non-injured 

adult human brain 

Jadranka Macas 1 , Christian Nern 1 , Josefine von Randow 1 , Alina Woszczyk 2 , Kea Franz 2 , Volker 

Seifert 2 , Karl Plate 1 , Stefan Momma 1 

Edinger Institute, Department of Neuropathology 1 , Department of Neurosurgery 2 , University Hospital 

Frankfurt, D-60528 Frankfurt, Germany 

P/D6 Multiple thromboembolic events in fetofetal transfusion in monochorionic 

triplets explaining pathogenesis of hydranencephaly 

M. Mittelbronn 1 , B. Goeppert 1 , R. Meyermann 1 , M. Meyer-Wittkopf 2 , H. Abele 3 , S. Haen 4 

1 Institute of Brain Research, University of Tuebingen, Germany, 2 Department of Gynecology, University 

of Bern, Switzerland 3 Department of Gynecology, 3 University of Tuebingen, Germany, 4 Institute of 

Pathology, University of Tuebingen, Germany 

P/D7 Selective striatal up-regulation of [3H]muscimol and [3H]AMPA receptor 

binding densities in rats after pravastatin treatment 

H. D. Müller 1 , Christian Berger 2 , Stefan Schwab 2 , C. Sommer 1 

1 2 

Dept. of Neuropathology, Johannes Gutenberg University of Mainz, Germany, Dept. of Neurology, 

Ruprecht Karls University of Heidelberg, Germany 

P/D8 Morphological findings of muscles, nerves and spinal cord in a severe case of 

spinal muscle atrophy (SMA type I) 

K. Müller 1 , Ch. Müller 2 , J. Kirschner 2 , S. Rudnik-Schöneborn 3 .B Volk 4 

1 Dep. of Neuropathology, Neurocenter, University of Freiburg, 2 Dep. of Neuropediatrics and Muscular 

Diseases, University of Freiburg, 3 Institute for Human Genetics, University of Aachen, 4 Dep. of 

Neuropathology, Neurocenter, University of Freiburg

P/D9 Potential contribution of hematopoietic cells to (re-)generation of Purkinje 

neurons in vivo 

Christian Nern, Ines Wolff, Jadranka Macas, Josefine von Randow, Ruth von Laer, Karl Plate, Stefan 

Momma 

Edinger Institute, Department of Neuropathology, University Hospital Frankfurt, D-60528 Frankfurt, 

Germany 

P/D10 NMDA receptor subunits in human and Bennett-rat spinal ganglia 

V. Ogunlade 1 , R. Schober 1 , S. Grimm 1 , C. Allgaier 2 

1 2 

Dept. of Neuropathology and Rudolf-Böhm-Institute of Pharmacology and Toxicology, University of 

Leipzig, Germany 

P/D11 Regional differences in incidence of chondrocalcinosis 

C. Schindler 1 , J. Haybäck 1 , J. Fischer 2 , Annette Kaiser 3 , K. Kuchelmeister 4 

1 Institute for Pathology , oö. Landesnervenklinik, Wagner – Jauregg-Weg 15, A-4020 Linz, Austria, 

2 Neurosurgical Clinics , oö. Landesnervenklinik, Wagner- Jauregg-Weg 15, A-4020 Linz, Austria, 

3 Institute for Pathology , Klinikum Nürnberg, Prof.-E. Nathan- Str. 1, D-90340 Nürnberg, Germany, 

4 Institute for Neuropathology der Universität, Arndtstr. 16, D- 35392 Gießen, Germany 

P/D12 Efficacy of clonal deletion versus anergy of self-reactive CD4 T-cells for the 

prevention and reversal of autoimmune diabetes 

Alexandru C. Stan 1 , Anca Preda-Pais 2 , Sofia Casares 3 , Constantin Bona 3 and Teodor-D. Brumeanu 2 

1 Institute of Neuropathology, Hannover Medical School, Hannover 30625, Germany, 2 Department of 

Medicine, Division of Immunology, Uniformed Services University of Health Sciences, Bethesda, MD 

20814, USA, 3 Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA 

P/D13 Histological features of cat colliculus inferior bearing short and long term 

auditory midbrain electrode implants 

A. C. Stan 1 , G. Reuter 2 , U. Reich 2 , N. Marquardt 2 , M.-N. Klingberg 2 , G. Paasche 2 , J. Patrick 3 , T. 

Lenarz 2 , M. Lenarz 2 

1 Department of Neuropathology, Hannover Medical School, Germany, 2 Department of Otolaryngology, 

Hannover Medical School, Germany, 3 Cochlear Ltd. Sydney 

P/D14 Epilepsy-associated neuronal cell death: interference with JNK-Bim signaling 

by intracellular Bcl-XL protein delivery. 

Panagiotis Theofilas, Anja zur Mühlen, Stephan Frank 

Universität Bonn, Neuropathologie, D-53105 Bonn 

P/D15 Upregulation and redistribution of aquaporins and inwardly rectifying 

potassium channels in high grade glioma: a crucial event in edema formation? 

A. Warth 1 , M. Mittelbronn 2 , H. Wolburg 1 

1 2 

Institute of Pathology, Eberhard-Karls University Tübingen Institute of Brain Research, Eberhard-Karls 

University Tübingen 

P/D16 Neuropathological findings in lethal multiple pterygium syndrome 

H. Woelk 1 , T. Kirchner 1 , D. May 2 , K. Kuchelmeister 1 ,W. Schachenmayr 1 

1 Institut für Neuropathologie, 2 Institut für Pathologie, Universitätsklinikum Gießen 

P/D17 Inhibition of NGF-induced neuronal differentiation of rat pheochromocytoma 

cells (PC12) following administration of dioxyamphetamine 

S. Zoubaa, G. Piontek, J. Schlegel 

Technische Universität München, Allgemeine Pathologie, 81675 München

Vorträge 

Postervorträge sind im Programm nicht vorgesehen. 

Die Dauer der Vorträge incl. anschließender Diskussion ist auf max. 10 min. begrenzt. 

Es wird darum gebeten, die vorgegebenen Zeiten nicht zu überschreiten. Durch die 

Terminierung und exakte Einhaltung der Zeiten konnte auf parallele Vortragsblöcke 

verzichtet werden. 

Themenkreise A- D 

A: Entzündung + Immunologie 

B: Degeneration + Epilepsie 

C: Onkologie 

D: Freie Themen + Muskel/Nerv 

A: Entzündung + Immunologie, Vorträge 

V/A1 Extensive cortical demyelination in MOG-induced EAE in the common marmoset 

Doron Merkler 1 , Barthel Schmelting 2 , Boldizsár Czéh 2 , Eberhard Fuchs 2,3,4 , Wolfgang Brück 1,3 , 

Christine Stadelmann 1 

1 Department of Neuropathology, Georg-August University Göttingen, Germany, 2 Clinical Neurobiology 

Laboratory, German Primate Center, Göttingen, Germany, 3 Institut für Multiple-Sklerose-Forschung, 

Bereich Humanmedizin der Universität Göttingen und Gemeinnützige Hertie-Stiftung, Göttingen, 

Germany, 4 Department of Neurology, Georg-August University Göttingen, Germany 

V/A2 CCR2 expression on myeloid cells is sufficient for disease development in a 

mouse model of multiple sclerosis 

Alexander Mildner, Hauke Schmidt, Harald Pruess, Josef Priller and Wolfgang Brück and Marco Prinz 

Universitätsklinikum Göttingen, Abteilung Neuropathologie, 37075 Göttingen 

V/A3 Innate Immunity mediated by CNS-resident cells modulates pathogenicity in an 

animal model of multiple sclerosis 

Marco Prinz, Folker Garbe, Hauke Schmidt, Alexander Mildner, Ilona Gutcher, Matthias Piesche, 

Roland Schroers, Elisabeth Weiss, Carsten J. Kirschning, Christian D.P. Rochford, Wolfgang Brück 

and Burkhard Becher

Georg-August-Universität, Institut für Neuropathologie, D-37075 Göttingen

V/A4 Lack of Type 1 Interferon Receptor (IFNAR) leads to exacerbation of 

experimental autoimmune encephalomyelitis 

Hauke Schmidt 1 , Alexander Mildner 1 , Uwe-Karsten Hanisch 1 , Wolfgang Brück 1 , Ulrich Kalinke 2 and 

Marco Prinz 1 

1 Department of Neuropathology, Georg August University, 37075 Göttingen, Germany, 2 Department of 

Immunology, Paul Ehrlich Institute,63225 Langen, Germany 

V/A5 An essential role for tumor necrosis factor in the formation of experimental 

murine Staphylococcus aureus-induced brain abscess and clearance 

Werner Stenzel, Sabine Soltek, Hrvoje Miletic, Manuel Marcel Hermann, Heinrich Körner, Jonathon 

D. Sedgwick, Dirk Schlüter, and Martina Deckert 

Universität zu Köln, Neuropathologie, 50931 Köln, Deutschland

B: Degeneration + Epilepsie, Vorträge 

V/B1 Neuron loss and axonopathy in transgenic mouse models for Alzheimer disease 

Thomas A. Bayer, Oliver Wirths, Christoph Schmitz, André Delacourte, Luc Buée, Joachim Weis 

Universität des Saarlandes Psychiatrie, Abtl. Neurobiologie 66421 Homburg/Saar Deutschland 

V/B2 Accumulation of amyloid ß protein causes a hierarchical degeneration of 

commissural neurons in the frontal cortex 

E. Capetillo-Zarate 1 , D. Abramowski 2 , M. Staufenbiel 2 , C. Haass 3, D.R. Thal 1 

1 Department of Neuropathology, University of Bonn, D-53105 Bonn, Germany, 2 Novartis Institutes for 

Biomedical Research Basel, Basel, Switzerland, 3 Biochemistry, Adolf-Butenandt Institute, Munich, 

Germany 

V/B3 Posttranslational prenylation, carboxyl methylation, and neurofibrillary 

degeneration 

R. Distl, V. Komkov, N. Holtkamp, S. Treiber-Held, F. Albert, V. Meske, Th. G. Ohm, A. v. Deimling 

Charité Universitätsmedizin Berlin, Institut für Neuropathologie, 13353 Berlin, Deutschland 

V/B4 Neuroprotective effects in hippocampal neurons vary with estrogen 

concentrations 

Lars Fester, Christian von Schassen, Veronica Ribeiro-Gouveia, Janine Prange-Kiel, Christina Lohse, 

Cornelia Huber, Gabriele M. Rune 

Universtätsklinikum Hamburg Eppendorf, Institut für Anatomie I: Zelluläre Neurobiologie, 20246 

Hamburg, BRD 

V/B5 Creutzfeldt Jakob disease in Austria: 10 years of surveillance 

Ellen Gelpi, Romana Höftberger, Ursula Unterberger, Thomas Ströbel, Till Voigtländer, Edita 

Drobna, and Herbert Budka 

Institute of Neurology, Medical University of Vienna, and Austrian Reference Centre for Human Prion 

Diseases (ÖRPE), Klinisches Institut für Neurologie der Medizinischen Universität Wien, 1097 Wien, 

Österreich 

V/B6 Memory acquisition in humans critically correlates with hippocampal granule 

cell loss 

Michelle Hildebrandt, Johann Romstöck, Hermann Stefan,Ingmar Blümcke, Elisabeth Pauli 

FAU Erlangen, Lehrstuhl für Neuropathologie, 91054 Erlangen, Deutschland 

V/B7 Neurodegenerative changes following induction of the interferon pathway by 

intraventricular delivery of synthetic siRNA in rat brain 

Frank K.H. van Landeghem, Nina Kaempfe, Stefan Angermair, Matthias Truss 1 , Anja Elstner, Stefan 

Schreiber, Arpad Von Moers 2 , Christian Hagemeier 1 , Christian Woiciechowsky 3 and Andreas von 

Deimling 

Institute of Neuropathology, 

1 

Department of Pediatric Molecular Genetics, 

2 

Department of 

Neuropediatrics, 3 Department of Neurosurgery, Charité-Universitätsmedizin Berlin, 13344 Berlin

V/B8 Mitochondrial tRNA-Leu(UUR) mutation causes Leigh-like encephalopathy in 

dogs 

Kaspar Matiasek, Sabine Hofmann, Kerstin Baiker, Andrea Fischer, Susanne Medl, Wolfgang 

Schmahl, Klaus-Dieter Gerbitz, Matthias Bauer 

LS für Neuropathologie, Institut für Tierpathologie – LMU, 80539 München, Germany 

V/B9 Role of the ß-Amyloid Precursor Protein Intracellular Domain (AICD) and Fe65 

in regulation of gene expression 

Thorsten Müller 1 , Donat Kögel 2 , Jochen H.M. Prehn 3 , and Rupert Egensperger 1 

1 Institute of Neuropathology, University Hospital Muenster, Muenster, Germany, 2 Center for Neurology 

and Neurosurgery, Johann Wolfgang Goethe University Clinics, Frankfurt, Germany, 3 Royal College of 

Surgeons in Ireland, Department of Physiology, Dublin 2, Ireland 

V/B10 Transplantation of arylsulfatase A overexpressing ES cell-derived glial 

precursors in an animal model of metachromatic leukodystrophy 

Tanja Schmandt 1 *, Diana Klein 2 *, Alberto Perez-Bouza 1 , Elke Muth-Köhne 1 , Volkmar Gieselmann 2 

and Oliver Brüstle 1 

1 Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn and Hertie Foundation, 

Bonn, Germany, 2 Institute of Physiological Chemistry, University of Bonn, Bonn, Germany 

*Authors contributed equally 

V/B11 Transplantation of adenosine-releasing ES cell-derived neural precursors: An 

experimental approach for seizure control 

Julius Steinbeck, Kristina Wernli, Michaela Segschneider, Detlev Boison und Oliver Brüstle 

Universität Bonn, Institut für rekonstruktive Neurobiologie, 53127 Bonn, Deutschland 

V/B12 Apolipoprotein E (apoE) occurs in newly formed plaques containing Aßdeposits 

not detectable with antibodies raised against N-terminal epitopes of Aß 

D.R. Thal 1 , E. Capetillo-Zarate 1 , C. Schultz 2 , U. Rüb 2 , T.C. Saido 3 , H. Yamaguchi 4 , C. Haass 5 , 

W.S.T. Griffin 6 , K. Del Tredici 2 , H. Braak 2 , E. Ghebremedhin 2 

1 Department of Neuropathology, University of Bonn, 2 Department of Clinical Neuroanatomy, University of 

Frankfurt, 3 Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Saitama, 4 Gunma 

University School of Health Sciences, Gunma, Japan, 5 Department of Biochemistry, A. Butenandt 

Institute, LMU, Munich, Germany, 6 D.W. Reynolds Center on Aging, UAMS, Little Rock, AR, USA

C: Onkologie, Vorträge 

V/C1 Choroid plexus tumors differ from metastatic carcinomas by expression of 

EAAT-1 

R. Beschorner, J. Schittenhelm, J.R. Iglesias-Rozas, T. Herberts, H. Schimmel, H. Schlaszus1, R. 

Meyermann, M. Wehrmann 

Institut für Hirnforschung, 72076 Tübingen 

V/C2 Primary leptomeningeal primitive neuroectodermal tumor with subseqent 

development of a glioblastoma 

Gies U., Pekrun A., Neubauer U., Bergmann M. 

Klinikum-Bremen-Ost, Neuropathologie, 28325 Bremen, Deutschland 

V/C3 Infantile minigemistocytic glioma: a distinct glioma variant, report of two 

cases 

Christine Haberler, Irene Slavc, Thomas Czech, Daniela Prayer, Christine Pirker, Herbert Budka, 

Johannes A. Hainfellner 

Medizinische Universität Wien, Klinisches Institut für Neurologie, A-1097 Wien, Österreich 

V/C4 NF2 mutations in secretory and other rare variants of meningiomas 

Christian Hartmann, Jennifer Sieberns, Claire Gehlhaar, Matthias Simon, Werner Paulus, Andreas 

von Deimling 

Charité - Humboldt Universität, Institut für Neuropathologie, 13353 Berlin, Deutschland 

V/C5 Microarray-based identification of novel diagnostic markers for ependymomas 

Martin Hasselblatt, Lars Tatenhorst, Werner Paulus 

Institute of Neuropathology, University Hospital Münster, Germany 

V/C6 Intracerebral mature teratoma in a case of Delleman syndrome 

Hey K., Spranger S., Meyer H., Neubauer U., Bergmann M. 

Klinikum-Bremen-Ost, Neuropathologie, 28325 Bremen, Deutschland 

V/C7 Ex vivo therapy of malignant melanomas transplanted into organotypic brain 

slice cultures using inhibitors of histone deacetylases 

Annett Hölsken, Florian A. Siebzehnrübl, Ilker Y. Eyüpoglu, Mike Lueders, Christian Tränkle, Detlef 

Dieckmann,Rolf Buslei, Eric Hahnen, and Ingmar Blümcke 

Universität Erlangen, Neuropathologie, 91054 Erlangen 

V/C8 Lymphocytic infiltration in human brain metastasis investigated with the 

Network SOM and HneT2000 

José R. Iglesias-Rozas and John Sutherland 

Institute of Pathology, Katharinenhospital, Stuttgart, Germany and ANDCorporation, Toronto, Ontario, 

Canada

V/C9 Expression and function of glioma invasion related genes in Drosophila glia 

cells 

Astrid Jeibmann, Hanna Witte, Christian Klämbt, Werner Paulus 

Institutes of Neuropathology and Neurobiology, University Hospital and Westfälische Wilhelms University, 

Münster, Germany 

V/C10 Recurrence in meningiomas: predictive value of histological, clinical, and 

cytogenetical data 

Yoo-Jin Kim 1 , Ralf Ketter 2 , Wolfram Henn 3 , Klaus D. Zang 3 , Wolf- Ingo Steudel 2 , Wolfgang Feiden 1 

1 Institute of Neuropathology, University of Saarland, School of Medicine, Homburg/Saar, 

Germany,. 2 Clinic for Neurosurgery, University of Saarland, School of Medicine, Homburg/Saar, Germany, 

3 Institute of Human Genetics, University of Saarland, School of Medicine, Homburg/Saar, Germany 

V/C11 Increase of macrophage migration inhibitory factor (MIF) expression in human 

malignant glioma may contribute to immune escape and proliferation 

M. Mittelbronn 1 , R. Meyermann 1 , M. Weller 2 , J. Wischhusen 2 

1 Institute of Brain Research, University of Tuebingen, Germany 2 Department of General Neurology and 

Hertie-Institut für Clinical Brain Research, University of Tuebingen, Germany 

V/C12 5'Aza-dc treatment and microarray analysis unveil epigenome in GBM 

Wolf Mueller 1,2 , Markus J Riemenschneider 1 , Catherine L Nutt 1 , David N Louis 1 

1 Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and 

Harvard Medical School, Boston, Massachusetts 02129, USA, 2 Department of Neuropathology, University 

Hospital Charite, Augustenburger Platz 1, 13353 Berlin, Germany 

V/C13 Comparative analysis of NeuN immunoreactivity in primary brain tumors: 

conclusions for rational use in diagnostic histopathology 

Matthias Preusser 1 , Ute Laggner 1 , Christine Haberler 1 , Harald Heinzl 2 , Herbert Budka 1 , Johannes A. 

Hainfellner 1 

1 2 

Institute of Neurology, Core Unit for Medical Statistics and Informatics, Medical University Vienna, 

Austria 

V/C14 Microvessel density and vascular patterns in glioblastoma: poor observer 

agreement invalidates prognostic impact 

A translational research project of the EORTC Brain Tumor Group. 

Preusser M 1 , Gelpi E 1 , Schönegger K 1 , Haberler C 1 , Fischer I 1 , Birner P 2 , Heinzl H 3 , Marosi C 4 , Hegi 

M 5 , Stupp R 6 , Gorlia T 7 , Hainfellner JA 1 

1 Institute of Neurology, 2 Institute of Pathology, 3 Core Unit for Medical Statistics and Informatics, 

4 Department of Internal Medicine I, Medical University Vienna, Austria, 5 Laboratory of Tumor Biology and 

Genetics, Department of Neurosurgery, University Hospital Lausanne, Lausanne and the National Center 

of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, 

Epalinges, Switzerland, 6 Multidisciplinary Oncology Center, University Hospital Lausanne, Lausanne, 

Switzerland, 7 Data Center, European Organisation for Research and Treatment of Cancer, Brussels 

V/C15 Characterization of a putative tumor stem cell in malignant brain tumors 

D. Sommerlad, M. Nister, K.H. Plate, J. Frisén, T. Acker 

Neurologisches Institut (Edinger-Institut), 60528 Frankfurt am Main, Deutschland

D: Freie Themen + Muskel/Nerv, Vorträge 

V/D1 Hypermethylation and reduced expression of SOCS-1 in pituitary adenomas 

R. Buslei, J. Kreutzer, B. Hofmann, V. Schmidt, F. Siebzehnrübl, E. Hahnen, I.Y. Eyupoglu, R. 

Fahlbusch, I. Blümcke 

Friedrich-Alexander-Universität Erlangen-Nürnberg, Lehrstuhl für Neuropathologie, 91054 Erlangen, 

Deutschland 

V/D2 Macrophagic myofasciitis 

Soroush Doostkam 1 , Jürgen R.E. Bohl 1 , Peter F. Schmidt 2 , Harald D. Müller 1 , Clemens Sommer 1 

and Hans H. Goebel 1 

1 Department of Neuropathology, Johannes Gutenberg University Mainz, 55131 Mainz, Germany, 

2 Institute for Medical Physics and Biophysics, Westfälische Wilhelms-University, Münster, Germany 

V/D3 Therapy of Spinal Muscular Atrophy using Suberoylanilide Hydroxamic Acid, a 

second generation Histone Deacetylase Inhibitor 

Eric Hahnen, Ilker Y. Eyüpoglu, Lars Brichta, Kirsten Haastert, Christian Tränkle, Florian A. 

Siebzehnrübl, Markus Riessland, Irmgard Hölker, Peter Claus, Johann Romstöck, Rolf Buslei, 

Brunhilde Wirth, Ingmar Blümcke 

Universität Köln, Institut für Humangenetik, 50931 Köln, Germany 

V/D4 Neuropathology of mevalonic aciduria (Neuropathologie der Mevalonazidurie) 

T. Kirchner 1 , H. Woelk 1 , D. May 2 , B. Ruf 3 , K. Kuchelmeister 1 , W. Schachenmayr 1 

1 Institut für Neuropathologie, 2 Institut für Pathologie, 3 Abteilung Neonatologie am Zentrum für 

Kinderheilkunde und Jugendmedizin, Universitätsklinikum Gießen 

V/D5 Generation of Stably Proliferating Neural Precursors from Human Embryonic 

Stem Cells 

Philipp Koch, Julia Ladewig, Andrea Biegler, Barbara Steinfarz and Oliver Brüstle 

Institute of Reconstructive Neurobiology, University of Bonn Life & Brain Center, Bonn, Germany 

V/D6 P0106-125 is a neuritogenic epitope of the peripheral myelin protein P0 and 

induces autoimmune neuritis in C57BL/6 mice 

Hrvoje Miletic, Olaf Utermöhlen, Christoph Wedekind, Manuel Hermann, Werner Stenzel, Hans 

Lassmann, Dirk Schlüter, and Martina Deckert 

Universität zu Köln, Abteilung für Neuropathologie, 50931 Köln, Deutschland 

V/D7 RNA-Isolation of Microdissected Brain Tissues of Lewis Rats Infected with the 

Borna Disease Virus after various Pre-Treatments to destroy infectivity 

Doris Porombka 1 , Sibylle Herzog 2 , Wolfgang Baumgartner 1 , Christiane Herden 1 

1 2 

Department of Pathology, University of Veterinary Medicine Hannover, Institute of Virology, Justus- 

Liebig-Universität Giessen, Germany 

V/D8 Inhibitors of Histone Deacetylases Increase Neuronal Fate Determination in 

Adult Stem Cells of the Rodent Brain 

Florian A Siebzehnrubl, Ilker Y Eyupoglu, Eric Hahnen, Rolf Buslei, Ingmar Blümcke 

Universität Erlangen, Neuropathologie, 91054 Erlangen, Deutschland 

V/D9 Neuropathological findings following asphyxia in a term infant: A combination 

of typical lesion patterns? 

Gisela Stoltenburg-Didinger 1 , Lars Garten 2 , Dieter Hüseman 2 , Siegbert Heck 3 , Michael Obladen 2 

1 Institute of Neuropathology, Charité, University Medicine, Berlin, 2 Department of Neonatology, Charité, 

University Medicine, Berlin, 3 Department of Obstetrics and Gynecology, Waldfriede Hospital, Berlin

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