List of Publications by TSRI Alumni 1988 - Kellogg School of ...

List of Publications by TSRI Alumni
1988 – January 2009
1. Moore JM, Case DA, Chazin WJ, Gippert GP, Havel TF, Powls R, Wright PE.
(1988) 3-dimensional solution structure of plastocyanin from the green-alga
scenedesmus-obliquus. Science. 240(4850): 314-7.
2. Lee MS, Gippert GP, Soman KV, Case DA, Wright PE. (1989) 3-dimensional
solution structure of a single zinc finger DNA-binding domain. Science. 245(4918): 635-
7.
3. Dyson HJ, Gippert GP, Case DA, Holmgren A, Wright PE. (1990) 3-dimensional
solution structure of the reduced form of escherichia-coli thioredoxin determined by
nuclear-magnetic-resonance spectroscopy. Biochemistry. 29(17): 4129-36.
4. Klinman NR, Decker DJ. (1990) Diversity 1990. Immunol. Rev. 115: 211-38.
5. McRee DE, Redford SM, Getzoff ED, Lepock JR, Hallewell RA, Tainer JA. (1990)
Changes in crystallographic structure and thermostability of a cu,zn superoxidedismutase
mutant resulting from the removal of a buried cysteine. J. Biol. Chem.
265(24): 14234-41.
6. McRee DE, Redford SM, Meyer TE, Cusanovich MA. (1990) Crystallization and
characterization of chromatium-vinosum cytochrome-c'. J. Biol. Chem. 265(10): 5364-5.
7. Redford SM, McRee DE, Getzoff ED, Steinman HM, Tainer JA. (1990)
Crystallographic characterization of a cu,zn superoxide-dismutase from photobacteriumleiognathi.
J. Mol. Biol. 212(3): 449-51.
8. Acevedo OL, Dickinson LA, Macke TJ, Thomas CA. (1991) The coherence of
synthetic telomeres. Nucleic Acids Res. 19(12): 3409-19.
9. Boger DL, Zhu Y. (1991) Studies on the synthesis of rubrolone - 4-pi participation
of o-alkyl alpha,beta-unsaturated oximes in intramolecular [4 + 2] cycloaddition
reactions. Tetrahedron Lett. 32(52): 7643-6.
10. Bowdish K, Tang Y, Hicks JB, Hilvert D. (1991) Yeast expression of a catalytic
antibody with chorismate mutase activity. J. Biol. Chem. 266(18): 11901-8.
11. Decker DJ, Boyle NE, Klinman NR. (1991) Predominance of nonproductive
rearrangements of vh81x gene segments evidences a dependence of b-cell clonal
maturation on the structure of nascent h-chains. J. Immunol. 147(4): 1406-11.
12. Decker DJ, Boyle NE, Koziol JA, Klinman NR. (1991) The expression of the ig hchain
repertoire in developing bone-marrow b-lineage cells. J. Immunol. 146(1): 350-61.
13. Decker DJ, Klinman NR. (1991) Developmental selection complements
evolutionary determination - reply. Immunol. Today. 12(11): 421-.
14. Ghiara JB, Richardson HE, Sugimoto K, Henze M, Lew DJ, Wittenberg C, Reed
SI. (1991) A cyclin-b homolog in saccharomyces-cerevisiae - chronic activation of the
cdc28 protein-kinase by cyclin prevents exit from mitosis. Cell. 65(1): 163-74.
15. Moore JM, Lepre CA, Gippert GP, Chazin WJ, Case DA, Wright PE. (1991) Highresolution
solution structure of reduced french bean plastocyanin and comparison with
the crystal-structure of poplar plastocyanin. J. Mol. Biol. 221(2): 533-55.
16. Tang Y, Hicks JB, Hilvert D. (1991) Invivo catalysis of a metabolically essential
reaction by an antibody. Proc. Natl. Acad. Sci. U. S. A. 88(19): 8784-6.
17. Baca M, Kent SBH. (1992) Direct observation of a ternary complex between the
dimeric enzyme hiv-1 protease and a substrate-based inhibitor. J. Am. Chem. Soc.
114(10): 3992-3.
Page 1 of 212

18. Fairbrother WJ, Gippert GP, Reizer J, Saier MH, Wright PE. (1992) Low
resolution solution structure of the bacillus-subtilis glucose permease-iia domain derived
from heteronuclear 3-dimensional nmr-spectroscopy. FEBS Lett. 296(2): 148-52.
19. Fernholz E, Schloeder D, Liu KKC, Bradshaw CW, Huang HM, Janda K, Lerner
RA, Wong CH. (1992) Specificity of antibody-catalyzed transesterifications using enol
esters - a comparison with lipase reactions. J. Org. Chem. 57(17): 4756-61.
20. Hecht D, Tadesse L, Walters L. (1992) Defining hydrophobicity - probing the
structure of solute-induced hydration shells by fourier-transform infrared-spectroscopy.
J. Am. Chem. Soc. 114(11): 4336-9.
21. Ichikawa Y, Sim MM, Wong CH. (1992) Efficient chemical synthesis of gdpfucose.
J. Org. Chem. 57(10): 2943-6.
22. Jones CM, Burkart MD, Whitmire KH. (1992) Bismuth alkoxide dimer complexes
containing planar bi2(mu-or)2 cores - syntheses and structures of [(bi[och(cf3)2]3(thf))2]
and [(bi(oc6f5)3(c7h8))2].2c7h8. Angewandte Chemie-International Edition in English.
31(4): 451-2.
23. Jones CM, Burkart MD, Whitmire KH. (1992) Novel aryloxybismuthoxide clusters
- x-ray crystal-structures of bi6(mu-3-o)7(mu-3-oc6f5)(bi(oc6f5)4)3(thf)2 and bi6(mu-3o)7(mu-3-oc6f5)(bi(oc6f5)4)3.2c7h8
(thf = tetrahydrofuran). J. Chem. Soc.-Chem.
Commun. (22): 1638-9.
24. Lin CH, Sugai T, Halcomb RL, Ichikawa Y, Wong CH. (1992) Unusual
stereoselectivity in sialic-acid aldolase-catalyzed aldol condensations - synthesis of both
enantiomers of high-carbon monosaccharides. J. Am. Chem. Soc. 114(26): 10138-45.
25. Nicolaou KC, Clark D. (1992) Total synthesis of the carbohydrate fragments of
esperamicin-a1. Angew. Chem.-Int. Edit. 31(7): 855-7.
26. Nicolaou KC, Liu A, Zeng Z, McComb S. (1992) Redox-controlled bergman
cycloaromatizations - designed enediynes with DNA-cleaving properties and antitumoractivity.
J. Am. Chem. Soc. 114(24): 9279-82.
27. Nicolaou KC, Liu JJ, Hwang CK, Dai WM, Guy RK. (1992) Synthesis of a fully
functionalized cd ring-system of taxol. J. Chem. Soc.-Chem. Commun. (16): 1118-20.
28. Vieth M, Kolinski A, Skolnick J, Sikorski A. (1992) Prediction of protein secondary
structure by neural networks - encoding short and long-range patterns of amino-acid
packing. Acta Biochim. Pol. 39(4): 369-92.
29. Wong CH, Wang R, Ichikawa Y. (1992) Regeneration of sugar nucleotide for
enzymatic oligosaccharide synthesis - use of gal-1-phosphate uridyltransferase in the
regeneration of udp-galactose, udp-2-deoxygalactose, and udp-galactosamine. J. Org.
Chem. 57(16): 4343-4.
30. Ashley JA, Lo CHL, McElhaney GP, Wirsching P, Janda KD. (1993) A catalytic
antibody model for plp-dependent decarboxylases. J. Am. Chem. Soc. 115(6): 2515-6.
31. Baca M, Alewood PF, Kent SBH. (1993) Structural-engineering of the hiv-1
protease molecule with a beta-turn mimic of fixed geometry. Protein Sci. 2(7): 1085-91.
32. Baca M, Kent SBH. (1993) Catalytic contribution of flap-substrate hydrogenbonds
in hiv-1 protease explored by chemical synthesis. Proc. Natl. Acad. Sci. U. S. A.
90(24): 11638-42.
33. Barbas CF, Rosenblum JS, Lerner RA. (1993) Direct selection of antibodies that

coordinate metals from semisynthetic combinatorial libraries. Proc. Natl. Acad. Sci. U. S.
A. 90(14): 6385-9.
34. Boger DL, Yohannes D, Zhou JC, Patane MA. (1993) Total synthesis of
cycloisodityrosine, ra-vii, deoxybouvardin, and n29-desmethyl-ra-vii - identification of the
pharmacophore and reversal of the subunit functional roles. J. Am. Chem. Soc. 115(9):
3420-30.
35. Boger DL, Zhou JC. (1993) Cdpi3-enediyne and cdpi3-edta conjugates - a new
class of DNA cleaving agents. J. Org. Chem. 58(11): 3018-24.
36. Boger DL, Zhou JC. (1993) Total synthesis of (+)-piperazinomycin. J. Am. Chem.
Soc. 115(24): 11426-33.
37. Campbell AP, Tarasow TM, Massefski W, Wright PE, Hilvert D. (1993) Binding of
a high-energy substrate conformer in antibody catalysis. Proc. Natl. Acad. Sci. U. S. A.
90(18): 8663-7.
38. Dawson PE, Kent SBH. (1993) Convenient total synthesis of a 4-helix tasp
molecule by chemoselective ligation. J. Am. Chem. Soc. 115(16): 7263-6.
39. Gray D, Mitchell GBB, Purnell RE. (1993) Efficacy of morantel citrate against
benzimidazole-resistant field strains of ostertagia-circumcincta. Vet. Rec. 132(26): 657-
8.
40. Hecht D, Tadesse L, Walters L. (1993) Correlating hydration shell structure with
amino-acid hydrophobicity. J. Am. Chem. Soc. 115(8): 3336-7.
41. Jones CM, Burkart MD, Bachman RE, Serra DL, Hwu SJ, Whitmire KH. (1993)
Hypervalent bismuth alkoxide dimer complexes - syntheses, structures, and thermal
decompositions of [bi(och(cf3)2)2(mu-och(cf3)2)(thf)]2 and [bi(oc6f5)2(mu-oc6f5)xn]2center-dot-zy
(x = y = c7h8, n = 1, z = 1 or 2 x = thf, y = c6h14, n = 2, z = 0 or 1). Inorg.
Chem. 32(23): 5136-44.
42. Nicolaou KC, Smith AL, Yue EW. (1993) Chemistry and biology of natural and
designed enediynes. Proc. Natl. Acad. Sci. U. S. A. 90(13): 5881-8.
43. Rayment I, Holden HM, Whittaker M, Yohn CB, Lorenz M, Holmes KC, Milligan
RA. (1993) Structure of the actin-myosin complex and its implications for musclecontraction.
Science. 261(5117): 58-65.
44. Schiavo G, Santucci A, Dasgupta BR, Mehta PP, Jontes J, Benfenati F, Wilson
MC, Montecucco C. (1993) Botulinum neurotoxins serotype-a and serotype-e cleave
snap-25 at distinct cooh-terminal peptide-bonds. FEBS Lett. 335(1): 99-103.
45. Sim MM, Kondo H, Wong CH. (1993) Synthesis and use of glycosyl phosphites -
an effective route to glycosyl phosphates, sugar nucleotides, and glycosides. J. Am.
Chem. Soc. 115(6): 2260-7.
46. Wong CH, Ichikawa Y, Kajimoto T, Liu KKC, Shen GJ, Lin CH, Wang YF, Dumas
DP, Lin YC, Wang R, Look GC. (1993) Practical synthesis of carbohydrates based on
aldolases and glycosyl transferases. Pure Appl. Chem. 65(4): 803-8.
47. Wong CH, Schuster M, Wang P, Sears P. (1993) Enzymatic-synthesis of n-linked
and o-linked glycopeptides. J. Am. Chem. Soc. 115(14): 5893-901.
48. Wu L, Russell P. (1993) Nim1 kinase promotes mitosis by inactivating wee1
tyrosine kinase. Nature. 363(6431): 738-41.
49. Baca M, Borgstahl GEO, Boissinot M, Burke PM, Williams DR, Slater KA, Getzoff

ED. (1994) Complete chemical-structure of photoactive yellow protein - novel thioesterlinked
4-hydroxycinnamyl chromophore and photocycle chemist. Biochemistry. 33(48):
14369-77.
50. Barbas SM, Ghazal P, Barbas CF, Burton DR. (1994) Recognition of DNA by
synthetic antibodies. J. Am. Chem. Soc. 116(5): 2161-2.
51. Boger DL, Johnson DS, Yun WY. (1994) (+)- and ent-(-)-duocarmycin sa and (+)-
and ent-(-)-n-boc-dsa DNA alkylation properties - alkylation site models that
accommodate the offset at-rich adenine n3 alkylation selectivity of the enantiomeric
agents. J. Am. Chem. Soc. 116(5): 1635-56.
52. Boger DL, Lerner RA, Cravatt BF. (1994) Synthesis of a functionalized rigid
bicyclo[2.2.1]heptane - a useful hapten for eliciting catalytic antibodies. J. Org. Chem.
59(17): 5078-9.
53. Boger DL, Mesini P, Tarby CM. (1994) Chemical and structural comparison of nboc-cbq
and n-boc-cbi - identification and structural origin of an unappreciated but
productive stability of the cc-1065 and duocarmycin sa alkylation subunits. J. Am.
Chem. Soc. 116(14): 6461-2.
54. Boger DL, Patane MA, Zhou JC. (1994) Total synthesis of bouvardin, omethylbouvardin,
and o-methyl-n-9-desmethylbouvardin. J. Am. Chem. Soc. 116(19):
8544-56.
55. Boger DL, Zhu Y. (1994) Diels-alder reactions of cyclopropenone ketals - a
concise tropolone annulation applicable to rubrolone-c ring introduction. J. Org. Chem.
59(12): 3453-8.
56. Brooks PC, Montgomery AMP, Rosenfeld M, Reisfeld RA, Hu TH, Klier G,
Cheresh DA. (1994) Integrin alpha(v)beta(3) antagonists promote tumor-regression by
inducing apoptosis of angiogenic blood-vessels. Cell. 79(7): 1157-64.
57. Byrd DA, Sweet DJ, Pante N, Konstantinov KN, Guan TL, Saphire ACS, Mitchell
PJ, Cooper CS, Aebi U, Gerace L. (1994) Tpr, a large coiled-coil protein whose aminoterminus
is involved in activation of oncogenic kinases, is localized to the cytoplasmic
surface of the nuclear-pore complex. J. Cell Biol. 127(6): 1515-26.
58. Clark DA, Dericcardis F, Nicolaou KC. (1994) Studies towards the synthesis of
esperamicinone. Tetrahedron. 50(39): 11391-426.
59. Cravatt BF, Ashley JA, Janda KD, Boger DL, Lerner RA. (1994) Crossing
extreme mechanistic barriers by antibody catalysis - syn elimination to a cis olefin. J.
Am. Chem. Soc. 116(13): 6013-4.
60. Dawson PE, Muir TW, Clarklewis I, Kent SBH. (1994) Synthesis of proteins by
native chemical ligation. Science. 266(5186): 776-9.
61. Ditzel HJ, Barbas SM, Barbas CF, Burton DR. (1994) The nature of the
autoimmune antibody repertoire in human-immunodeficiency-virus type-1 infection.
Proc. Natl. Acad. Sci. U. S. A. 91(9): 3710-4.
62. Doyle TJ, Hendrix M, Haseltine J. (1994) A novel case of cationic rearrangement
involving a phenonium ion. Tetrahedron Lett. 35(45): 8295-8.
63. Fitzgerald MM, Churchill MJ, McRee DE, Goodin DB. (1994) Small-molecule
binding to an artificially created cavity at the active-site of cytochrome-c peroxidase.
Biochemistry. 33(13): 3807-18.

64. Ghiara JB, Stura EA, Stanfield RL, Profy AT, Wilson IA. (1994) Crystal-structure
of the principal neutralization site of hiv-1. Science. 264(5155): 82-5.
65. Halcomb RL, Huang HM, Wong CH. (1994) Solution-phase and solid-phase
synthesis of inhibitors of helicobacter-pylori attachment and e-selectin-mediated
leukocyte adhesion. J. Am. Chem. Soc. 116(25): 11315-22.
66. Harper JF, Huang JF, Lloyd SJ. (1994) Genetic identification of an autoinhibitor in
cdpk, a protein-kinase with a calmodulin-like domain. Biochemistry. 33(23): 7267-77.
67. Haynes MR, Stura EA, Hilvert D, Wilson IA. (1994) Crystallization and preliminary
structural studies of a chorismate mutase catalytic antibody complexed with a transitionstate
analog. Proteins-Structure Function and Genetics. 18(2): 198-200.
68. Haynes MR, Stura EA, Hilvert D, Wilson IA. (1994) Routes to catalysis - structure
of a catalytic antibody and comparison with its natural counterpart. Science. 263(5147):
646-52.
69. Henderson I, Laslo K, Wong CH. (1994) Chemoenzymatic synthesis of
homoazasugars. Tetrahedron Lett. 35(3): 359-62.
70. Ichikawa Y, Wang R, Wong CH. (1994) Regeneration of sugar nucleotide for
enzymatic oligosaccharide synthesis. Methods Enzymol. 247: 107-27.
71. Janda KD, Lo CHL, Li TY, Barbas CF, Wirsching P, Lerner RA. (1994) Direct
selection for a catalytic mechanism from combinatorial antibody libraries. Proc. Natl.
Acad. Sci. U. S. A. 91(7): 2532-6.
72. Lejohn HB, Cameron LE, Yang BH, Macbeath G, Barker DS, Williams SA. (1994)
Cloning and analysis of a constitutive heat-shock (cognate) protein-70 gene inducible by
l-glutamine. J. Biol. Chem. 269(6): 4513-22.
73. Lerner RA, Siuzdak G, Prosperogarcia O, Henriksen SJ, Boger DL, Cravatt BF.
(1994) Cerebrodiene - a brain lipid isolated from sleep-deprived cats. Proc. Natl. Acad.
Sci. U. S. A. 91(20): 9505-8.
74. Macbeath G, Hilvert D. (1994) Monitoring catalytic activity by immunoassay -
implications for screening. J. Am. Chem. Soc. 116(14): 6101-6.
75. Mayfield SP, Cohen A, Danon A, Yohn CB. (1994) Translation of the psba
messenger-rna of chlamydomonas-reinhardtii requires a structured rna element
contained within the 5' untranslated region. J. Cell Biol. 127(6): 1537-45.
76. Morris KN, Tarasow TM, Julin CM, Simons SL, Hilvert D, Gold L. (1994)
Enrichment for rna molecules that bind a diels-alder transition-state analog. Proc. Natl.
Acad. Sci. U. S. A. 91(26): 13028-32.
77. Nicolaou KC, Claiborne CF, Nantermet PG, Couladouros EA, Sorensen EJ.
(1994) Synthesis of novel taxoids. J. Am. Chem. Soc. 116(4): 1591-2.
78. Nicolaou KC, Couladouros EA, Nantermet PG, Renaud J, Guy RK, Wrasidlo W.
(1994) Synthesis of c-2 taxol analogs. Angew. Chem.-Int. Edit. 33(15-16): 1581-3.
79. Nicolaou KC, Dai WM, Guy RK. (1994) Chemistry and biology of taxol. Angew.
Chem.-Int. Edit. 33(1): 15-44.
80. Nicolaou KC, Gross JL, Kerr MA, Lemus RH, Ikeda K, Ohe K. (1994) Synthesis
of the anthraquinone framework of dynemicin-a. Angew. Chem.-Int. Edit. 33(7): 781-3.
81. Nicolaou KC, Guy RK, Pitsinos EN, Wrasidlo W. (1994) A water-soluble prodrug
of taxol with self-assembling properties. Angew. Chem.-Int. Edit. 33(15-16): 1583-7.

82. Nicolaou KC, Nadin A, Leresche JE, Lagreca S, Tsuri T, Yue EW, Yang Z. (1994)
Synthesis of the first fully functionalized core of the zaragozic acids squalestatins.
Angew. Chem.-Int. Edit. 33(21): 2187-90.
83. Nicolaou KC, Nadin A, Leresche JE, Yue EW, Lagreca S. (1994) Total synthesis
of zaragozic-acid-a squalestatin-s1. Angew. Chem.-Int. Edit. 33(21): 2190-1.
84. Nicolaou KC, Nantermet PG, Ueno H, Guy RK. (1994) Novel chemistry of taxol -
retrosynthetic and synthetic studies. J. Chem. Soc.-Chem. Commun. (3): 295-6.
85. Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF,
Renaud J, Couladouros EA, Paulvannan K, Sorensen EJ. (1994) Total synthesis of
taxol. Nature. 367(6464): 630-4.
86. Nicolaou KC, Yue EW, Naniwa Y, Dericcardis F, Nadin A, Leresche JE, Lagreca
S, Yang Z. (1994) Zaragozic-acid-a squalestatin-s1 - synthetic and retrosynthetic
studies. Angew. Chem.-Int. Edit. 33(21): 2184-7.
87. Paloma LG, Smith JA, Chazin WJ, Nicolaou KC. (1994) Interaction of
calicheamicin with duplex DNA - role of the oligosaccharide domain and identification of
multiple binding modes. J. Am. Chem. Soc. 116(9): 3697-708.
88. Sears P, Schuster M, Wang P, Witte K, Wong CH. (1994) Engineering subtilisin
for peptide coupling - studies on the effects of counterions and site-specific
modifications on the stability and specificity of the enzyme. J. Am. Chem. Soc. 116(15):
6521-30.
89. Stillman CA, Linton PJ, Koutz PJ, Decker DJ, Klinman NR, Gingeras TR. (1994)
Specific immunoglobulin cdna clones produced from hybridoma cell-lines and murine
spleen fragment cultures by 3sr amplification. PCR-Methods Appl. 3(6): 320-31.
90. Tarasow TM, Lewis C, Hilvert D. (1994) Investigation of medium effects in a
family of decarboxylase antibodies. J. Am. Chem. Soc. 116(18): 7959-63.
91. Tsang J, Joyce GF. (1994) Evolutionary optimization of the catalytic properties of
a DNA-cleaving ribozyme. Biochemistry. 33(19): 5966-73.
92. Vieth M, Kolinski A, Brooks CL, Skolnick J. (1994) Prediction of the folding
pathways and structure of the gcn4 leucine-zipper. J. Mol. Biol. 237(4): 361-7.
93. Wilson IA, Ghiara JB, Stanfield RL. (1994) Structure of antipeptide antibody
complexes. Res. Immunol. 145(1): 73-8.
94. Wilson IA, Stanfield RL, Jewell DA, Ghiara JB, Fremont DH, Stura EA. (1994)
Immune recognition of viral-antigens. Infect. Agents Dis.-Rev. Issues Comment. 3(2-3):
155-62.
95. Wrasidlo W, Johnson DS, Boger DL. (1994) Induction of endonucleolytic DNA
fragmentation and apoptosis by the duocarmycins. Bioorg. Med. Chem. Lett. 4(4): 631-
6.
96. Baca M, Muir TW, Schnolzer M, Kent SBH. (1995) Chemical ligation of cysteinecontaining
peptides - synthesis of a 22-kda tethered dimer of hiv-1 protease. J. Am.
Chem. Soc. 117(7): 1881-7.
97. Balicki D, Beutler E. (1995) Gaucher disease. Medicine (Baltimore). 74(6): 305-
23.
98. Barbas SM, Ditzel HJ, Salonen EM, Yang WP, Silverman GJ, Burton DR. (1995)
Human autoantibody recognition of DNA. Proc. Natl. Acad. Sci. U. S. A. 92(7): 2529-33.

99. Beutler E, Demina A, Laubscher K, Garver P, Gelbart T, Balicki D, Vaughan L.
(1995) The clinical course of treated and untreated gaucher-disease - a study of 45
patients. Blood Cell Mol. Dis. 21(2): 86-108.
100. Boger DL, Colletti SL, Teramoto S, Ramsey TM, Zhou JC. (1995) Synthesis of
key analogs of bleomycin a(2) that permit a systematic evaluation of the linker region -
identification of an exceptionally prominent role for the l-threonine substituent. Bioorg.
Med. Chem. 3(9): 1281-95.
101. Boger DL, Johnson DS. (1995) 2nd definitive test of proposed models for the
origin of the cc-1065 and duocarmycin DNA alkylation selectivity. J. Am. Chem. Soc.
117(4): 1443-4.
102. Boger DL, Johnson DS. (1995) Cc-1065 and the duocarmycins - unraveling the
keys to a new class of naturally derived DNA alkylating-agents. Proc. Natl. Acad. Sci. U.
S. A. 92(9): 3642-9.
103. Boger DL, Patane MA, Zhou JC. (1995) Solution-phase conformational studies of
the cyclic peptide ra-vii - lithium-chloride perturbation of the conformational equilibria. J.
Am. Chem. Soc. 117(28): 7357-63.
104. Boger DL, Teramoto S, Honda T, Zhou JC. (1995) Synthesis and evaluation of
the fully functionalized bleomycin a(2) metal-binding domain-containing the 2-o-(3-ocarbamoyl-alpha-d-mannopyranosyl)-alpha-l-gulopyranosyl
disaccharide. J. Am. Chem.
Soc. 117(28): 7338-43.
105. Boger DL, Teramoto S, Zhou JC. (1995) Key synthetic analogs of bleomycin a(2)
that directly address the effect and role of the disaccharide - demannosylbleomycin a(2)
and alpha-d-mannopyranosyldeglycobleomycin a(2). J. Am. Chem. Soc. 117(28): 7344-
56.
106. Boger DL, Yun WY, Cai H, Han NH. (1995) Cbi-cdpbo1 and cbi-cdpbi1 - cc-1065
analogs containing deep-seated modifications in the DNA-binding subunit. Bioorg. Med.
Chem. 3(6): 761-75.
107. Boger DL, Yun WY, Han NH, Johnson DS. (1995) Cc-1065 cbi analogs - an
example of enhancement of DNA alkylation efficiency through introduction of stabilizing
electrostatic interactions. Bioorg. Med. Chem. 3(6): 611-21.
108. Boger DL, Zhou JC. (1995) N-desmethyl derivatives of deoxybouvardin and ra-vii
- synthesis and evaluation. J. Am. Chem. Soc. 117(28): 7364-78.
109. Boger DL, Zhou JC, Winter B, Kitos PA. (1995) Key analogs of the tetrapeptide
subunit of ra-vii and deoxybouvardin. Bioorg. Med. Chem. 3(12): 1579-93.
110. Boyce CW, Gillies CW, Warner H, Gillies JZ, Lovas FJ, Suenram RD. (1995)
Microwave-spectra, structure, and electric-dipole moment of the ar-isocyanic acid vander-waals
complex. J. Mol. Spectrosc. 171(2): 533-45.
111. Burgoon MP, Hazan RB, Phillips GR, Crossin KL, Edelman GM, Cunningham
BA. (1995) Functional-analysis of posttranslational cleavage products of the neuron-glia
cell-adhesion molecule, ng-cam. J. Cell Biol. 130(3): 733-44.
112. Carrera MRA, Ashley JA, Parsons LH, Wirsching P, Koob GF, Janda KD. (1995)
Suppression of psychoactive effects of cocaine by active immunization. Nature.
378(6558): 727-30.
113. Clark TD, Ghadiri MR. (1995) Supramolecular design by covalent capture -

design of a peptide cylinder via hydrogen-bond-promoted intermolecular olefin
metathesis. J. Am. Chem. Soc. 117(49): 12364-5.
114. Crane BR, Siegel LM, Getzoff ED. (1995) Sulfite reductase structure at 1.6
angstrom - evolution and catalysis for reduction of inorganic anions. Science.
270(5233): 59-67.
115. Cravatt BF, Prosperogarcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL,
Lerner RA. (1995) Chemical characterization of a family of brain lipids that induce sleep.
Science. 268(5216): 1506-9.
116. Dai XC, Demesmaeker A, Joyce GF. (1995) Cleavage of an amide bond by a
ribozyme. Science. 267(5195): 237-40.
117. Decker DJ, Kline GH, Hayden TA, Zaharevitz SN, Klinman NR. (1995) Heavychain-v
gene-specific elimination of b-cells during the pre-b-cell to b-cell transition. J.
Immunol. 154(10): 4924-35.
118. Decker DJ, Linton PJ, Zaharevitz S, Biery M, Gingeras TR, Klinman NR. (1995)
Defining subsets of naive and memory b-cells based on the ability of their progeny to
somatically mutate in-vitro. Immunity. 2(2): 195-203.
119. Duncan BS, Macke TJ, Olson AJ. (1995) Biomolecular visualization using avs. J.
Mol. Graph. 13(5): 271-+.
120. Fang JM, Lin CH, Bradshaw CW, Wong CH. (1995) Enzymes in organicsynthesis
- oxidoreductions (pg 967, 1995). J. Chem. Soc.-Perkin Trans. 1. (13): 1781-.
121. Fang JM, Lin CH, Bradshaw CW, Wong CH. (1995) Enzymes in organicsynthesis
- oxidoreductions. J. Chem. Soc.-Perkin Trans. 1. (8): 967-78.
122. Garner CM, Thomas AA. (1995) Allylic metalation of endocyclic and exocyclic
alkenes - anomalous high reactivity of beta-pinene. J. Org. Chem. 60(21): 7051-4.
123. Gottlieb RA, Giesing HA, Engler RL, Babior BM. (1995) The acid
deoxyribonuclease of neutrophils - a possible participant in apoptosis-associated
genome destruction. Blood. 86(6): 2414-8.
124. Gottlieb RA, Giesing HA, Zhu JY, Engler RL, Babior BM. (1995) Cell acidification
in apoptosis - granulocyte-colony-stimulating factor delays programmed cell-death in
neutrophils by up-regulating the vacuolar h+-atpase. Proc. Natl. Acad. Sci. U. S. A.
92(13): 5965-8.
125. Hogg JH, Ollmann IR, Haeggstrom JZ, Wetterholm A, Samuelsson B, Wong CH.
(1995) Amino hydroxamic acids as potent inhibitors of leukotriene a(4) hydrolase.
Bioorg. Med. Chem. 3(10): 1405-15.
126. Huang HM, Wong CH. (1995) Synthesis of biologically-active sialyl-lewis-x
mimetics. J. Org. Chem. 60(10): 3100-6.
127. Johnson CR, Xu YP, Nicolaou KC, Yang Z, Guy RK, Dong JG, Berova N. (1995)
Enzymatic resolution of a key stereochemical intermediate for the synthesis of (-)-taxol.
Tetrahedron Lett. 36(19): 3291-4.
128. Jontes JD, Wilsonkubalek EM, Milligan RA. (1995) A 32-degrees tail swing in
brush-border myosin-i on adp release. Nature. 378(6558): 751-3.
129. Kohar I, Baca M, Suarna C, Stocker R, Southwellkeely PT. (1995) Is alphatocopherol
a reservoir for alpha-tocopheryl hydroquinone. Free Radic. Biol. Med. 19(2):
197-207.

130. Lin CH, Shen GJ, Garciajunceda E, Wong CH. (1995) Enzymatic-synthesis and
regeneration of 3'-phosphoadenosine 5'-phosphosulfate (paps) for regioselective
sulfation of oligosaccharides. J. Am. Chem. Soc. 117(30): 8031-2.
131. Lin CH, Shimazaki M, Wong CH, Koketsu M, Juneja LR, Kim M. (1995)
Enzymatic synthesis of a sialyl lewis x dimer from egg yolk as an inhibitor of e-selectin.
Bioorg. Med. Chem. 3(12): 1625-30.
132. Marler JR, Brott T, Broderick J, Kothari R, Odonoghue M, Barsan W, Tomsick T,
Spilker J, Miller R, Sauerbeck L, Jarrell J, Kelly J, Perkins T, McDonald T, Rorick M,
Hickey C, Armitage J, Perry C, Thalinger K, Rhude R, Schill J, Becker PS, Heath RS,
Adams D, Reed R, Klei M, Hughes S, Anthony J, Baudendistel D, Zadicoff C, Rymer M,
Bettinger I, Laubinger P, Schmerler M, Meirose G, Lyden P, Rapp K, Babcock T, Daum
P, Persona D, Brody M, Jackson C, Lewis S, Liss J, Mahdavi Z, Rothrock J, Tom T,
Zweifler R, Dunford J, Zivin J, Kobayashi R, Kunin J, Licht J, Rowen R, Stein D, Grisolia
J, Martin F, Chaplin E, Kaplitz N, Nelson J, Neuren A, Silver D, Chippendale T, Diamond
E, Lobatz M, Murphy D, Rosenberg D, Ruel T, Sadoff M, Schim J, Schleimer J, Atkinson
R, Wentworth D, Cummings R, Frink R, Heublein P, Grotta JC, Degraba T, Fisher M,
Ramirez A, Hanson S, Morgenstern L, Sills C, Pasteur W, Yatsu F, Andrews K,
Villarcordova C, Pepe P, Bratina P, Greenberg L, Rozek S, Simmons K, Kwiatkowski
TG, Horowitz SH, Libman R, Kanner R, Silverman R, Lamantia J, Mealie C, Duarte R,
Donnarumma R, Okola M, Cullin V, Mitchell E, Levine SR, Lewandowski CA, Tokarski
G, Ramadan NM, Mitsias P, Gorman M, Zarowitz B, Kokkinos J, Dayno J, Verro P,
Gymnopoulos C, Dafer R, Dolhaberriague L, Sawaya K, Daley S, Mitchell M, Frankel M,
Mackay B, Barch C, Braimah J, Faherty B, Macdonald J, Sailor S, Cook A, Karp H,
Nguyen B, Washington J, Weissman J, Williams M, Williamson T, Kozinn M, Hellwick L,
Haley EC, Bleck TP, Cail WS, Lindbeck GH, Granner MA, Wolf SS, Gwynn MW,
Mettetal RW, Chang CWJ, Solenski NJ, Brock DG, Ford GF, Kongable GL, Parks KN,
Wilkinson SS, Davis MK, Sheppard GL, Zontine DW, Gustin KH, Crowe NM, Massey
SL, Meyer M, Gaines K, Payne A, Bales C, Malcolm J, Barlow R, Wilson M, Cape C,
Bertorini T, Misulis K, Paulsen W, Shepard D, Tilley BC, Welch KMA, Fagan SC, Lu M,
Patel S, Masha E, Verter J, Boura J, Main J, Gordon L, Maddy N, Chociemski T,
Windham J, Zadeh HS, Alves W, Keller MF, Wenzel JR, Raman N, Cantwell L, Warren
A, Smith K, Bailey E, Froehlich J, Breed J, Easton JD, Hallenbeck JF, Lan G, Marsh JD,
Walker MD. (1995) Tissue-plasminogen activator for acute ischemic stroke. N. Engl. J.
Med. 333(24): 1581-7.
133. Mayfield SP, Yohn CB, Cohen A, Danon A. (1995) Regulation of chloroplast
gene-expression. Annu. Rev. Plant Physiol. Plant Molec. Biol. 46: 147-66.
134. Nicolaou KC, Guy RK. (1995) The conquest of taxol. Angew. Chem.-Int. Edit.
34(19): 2079-90.
135. Nicolaou KC, Hwang CK, Duggan ME, Nugiel DA, Abe Y, Reddy KB, Defrees SA,
Reddy DR, Awartani RA, Conley SR, Rutjes F, Theodorakis EA. (1995) Total synthesis
of brevetoxin-b .1. First generation strategies and new approaches to oxepane systems.
J. Am. Chem. Soc. 117(41): 10227-38.
136. Nicolaou KC, Liu JJ, Yang Z, Ueno H, Sorensen EJ, Claiborne CF, Guy RK,
Hwang CK, Nakada M, Nantermet PG. (1995) Total synthesis of taxol .2. Construction

of a-ring and c-ring intermediates and initial attempts to construct the abc ring-system.
J. Am. Chem. Soc. 117(2): 634-44.
137. Nicolaou KC, Nantermet PG, Ueno H, Guy RK, Couladouros EA, Sorensen EJ.
(1995) Total synthesis of taxol .1. Retrosynthesis, degradation, and reconstitution. J.
Am. Chem. Soc. 117(2): 624-33.
138. Nicolaou KC, Renaud J, Nantermet PG, Couladouros EA, Guy RK, Wrasidlo W.
(1995) Chemical synthesis and biological evaluation of c-2 taxoids. J. Am. Chem. Soc.
117(9): 2409-20.
139. Nicolaou KC, Yang Z, Liu JJ, Nantermet PG, Claiborne CF, Renaud J, Guy RK,
Shibayama K. (1995) Total synthesis of taxol .3. Formation of taxols abc ring skeleton.
J. Am. Chem. Soc. 117(2): 645-52.
140. Nicolaou KC, Yue EW, Lagreca S, Nadin A, Yang Z, Leresche JE, Tsuri T,
Naniwa Y, Dericcardis F. (1995) Synthesis of zaragozic acid a/squalestatin s1. Chem.-
Eur. J. 1(7): 467-94.
141. Ollmann IR, Hogg JH, Munoz B, Haeggstrom JZ, Samuelsson B, Wong CH.
(1995) Investigation of the inhibition of leukotriene a(4) hydrolase. Bioorg. Med. Chem.
3(7): 969-95.
142. Peterson EB, Hilvert D. (1995) Nonessential active-site residues modulate
selenosubtilisins kinetic mechanism. Biochemistry. 34(20): 6616-20.
143. Phillips GR, Edelman GM, Crossin KL. (1995) Separate cell-binding sites within
cytotactin tenascin differentially promote neurite outgrowth. Cell Adhes. Commun. 3(3):
257-71.
144. Potts BCM, Smith J, Akke M, Macke TJ, Okazaki K, Hidaka H, Case DA, Chazin
WJ. (1995) The structure of calcyclin reveals a novel homodimeric fold for s100 ca2+binding
proteins. Nat. Struct. Biol. 2(9): 790-6.
145. Rosenblum JS, Lo LC, Li TY, Janda KD, Lerner RA. (1995) Antibody-catalyzed
phosphate triester hydrolysis. Angew. Chem.-Int. Edit. 34(20): 2275-7.
146. Schuur ER, Kruse U, Iacovoni JS, Vogt PK. (1995) Nuclear factor-i interferes with
transformation-induced by nuclear oncogenes. Cell Growth Differ. 6(3): 219-27.
147. Sheinerman FB, Brooks CL. (1995) 3(10)-helices in peptides and proteins as
studied by modified zimm-bragg theory. J. Am. Chem. Soc. 117(40): 10098-103.
148. Slee DH, Laslo KL, Elder JH, Ollmann IR, Gustchina A, Kervinen J, Zdanov A,
Wlodawer A, Wong CH. (1995) Selectivity in the inhibition of hiv and fiv protease -
inhibitory and mechanistic studies of pyrrolidine-containing alpha-keto amide and
hydroxyethylamine core structures. J. Am. Chem. Soc. 117(48): 11867-78.
149. Uchiyama T, Vassilev VP, Kajimoto T, Wong WC, Huang HM, Lin CC, Wong CH.
(1995) Design and synthesis of sialyl-lewis-x mimetics. J. Am. Chem. Soc. 117(19):
5395-6.
150. Vieth M, Kolinski A, Brooks CL, Skolnick J. (1995) Prediction of quaternary
structure of coiled coils - application to mutants of the gcn4 leucine-zipper. J. Mol. Biol.
251(3): 448-67.
151. Vieth M, Kolinski A, Skolnick J. (1995) A simple technique to estimate partitionfunctions
and equilibrium-constants from monte-carlo simulations. J. Chem. Phys.
102(15): 6189-93.

152. Whittaker M, Wilsonkubalek EM, Smith JE, Faust L, Milligan RA, Sweeney HL.
(1995) A 35-angstrom movement of smooth-muscle myosin on adp release. Nature.
378(6558): 748-51.
153. Wirsching P, Ashley JA, Lo CHL, Janda KD, Lerner RA. (1995) Reactive
immunization. Science. 270(5243): 1775-82.
154. Wong CH, Provencher L, Porco JA, Jung SH, Wang YF, Chen LR, Wang R,
Steensma DH. (1995) Synthesis and evaluation of homoazasugars as glycosidase
inhibitors. J. Org. Chem. 60(6): 1492-501.
155. Yin YH, Beachy RN. (1995) The regulatory regions of the rice tungro bacilliform
virus promoter and interacting nuclear factors in rice (oryza-sativa l). Plant J. 7(6): 969-
80.
156. Zhang ZY, Zhou GC, Denu JM, Wu L, Tang XJ, Mondesert O, Russell P, Butch
E, Guan KL. (1995) Purification and characterization of the low-molecular-weight
protein-tyrosine-phosphatase, stp1, from the fission yeast schizosaccharomycespombe.
Biochemistry. 34(33): 10560-8.
157. Alper PB, Hung SC, Wong CH. (1996) Metal catalyzed diazo transfer for the
synthesis of azides from amines. Tetrahedron Lett. 37(34): 6029-32.
158. Beutler E, Gelbart T, Balicki D, Demina A, Adusumalli J, Elsas L, Grinzaid KA,
Gitzelmann R, SupertiFurga A, Kattamis C, Liou BBH. (1996) Gaucher disease: Four
families with previously undescribed mutations. Proc. Assoc. Am. Physicians. 108(3):
179-84.
159. Bjornestedt R, Zhong GF, Lerner RA, Barbas CF. (1996) Copying nature's
mechanism for the decarboxylation of beta-keto acids into catalytic antibodies by
reactive immunization. J. Am. Chem. Soc. 118(47): 11720-4.
160. Boger DL, Bollinger B, Johnson DS. (1996) Examination of the role of the
duocarmycin sa methoxy substituents: Identification of the minimum, fully potent DNA
binding subunit. Bioorg. Med. Chem. Lett. 6(18): 2207-10.
161. Boger DL, Goldberg J, McKie JA. (1996) A comparative study of the solvolysis
reactivity, regioselectivity, and stereochemistry of the duocarmycin a and sa alkylation
subunits. Bioorg. Med. Chem. Lett. 6(16): 1955-60.
162. Boger DL, Han NH, Tarby CM, Boyce CW, Cai H, Jin Q, Kitos PA. (1996)
Synthesis, chemical properties, and preliminary evaluation of substituted cbi analogs of
cc-1065 and the duocarmycins incorporating the 7-cyano-1,2,9,9atetrahydrocyclopropa[c]benz[e]indol-4-one
alkylation subunit: Hammett quantitation of
the magnitude of electronic effects on functional reactivity. J. Org. Chem. 61(15): 4894-
912.
163. Boger DL, Johnson DS. (1996) Cc-1065 and the duocarmycins: Understanding
their biological function through mechanistic studies. Angew. Chem.-Int. Edit. 35(13-14):
1438-74.
164. Boger DL, McKie JA, Cai H, Cacciari B, Baraldi PG. (1996) Synthesis and
properties of substituted cbi analogs of cc-1065 and the duocarmycins incorporating the
7-methoxy-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (mcbi) alkylation subunit:
Magnitude of electronic effects on the functional reactivity. J. Org. Chem. 61(5): 1710-
29.

165. Boger DL, Ramsey TM, Cai H. (1996) Synthesis and evaluation of potential n-pi
and n-sigma metal chelation sites within the beta-hydroxy-l-histidine subunit of
bleomycin a(2): Functional characterization of imidazole n-pi metal complexation.
Bioorg. Med. Chem. 4(2): 195-207.
166. Boger DL, Tarby CM, Myers PL, Caporale LH. (1996) Generalized
dipeptidomimetic template: Solution phase parallel synthesis of combinatorial libraries.
J. Am. Chem. Soc. 118(8): 2109-10.
167. Boger DL, Teramoto S, Cai H. (1996) Synthesis and evaluation of
deglycobleomycin a(2) analogues containing a tertiary n-methyl amide and simple ester
replacement for the l-histidine secondary amide: Direct functional characterization of the
requirement for secondary amide metal complexation. Bioorg. Med. Chem. 4(2): 179-93.
168. Boger DL, Zhou JC. (1996) Key analogues of the tetrapeptide subunit of ra-vii
and deoxybouvardin. Bioorg. Med. Chem. 4(10): 1597-603.
169. Boger DL, Zhou JC. (1996) Alternative synthesis of the cycloisodityrosine subunit
of deoxybouvardin, ra-vii, and related agents: Reassignment of the stereochemistry of
prior intermediates. J. Org. Chem. 61(12): 3938-9.
170. Boger DL, Zhou JC, Borzilleri RM, Nukui S. (1996) Synthesis of (9s,12s)cycloisodityrosine
and its unnatural (9r,12s)-diastereomer. Bioorg. Med. Chem. Lett.
6(10): 1089-92.
171. Boger DL, Zhou JC, Cai H. (1996) Demonstration and definition of the
noncovalent binding selectivity of agents related to cc-1065 by an affinity cleavage
agent: Noncovalent binding coincidental with alkylation. Bioorg. Med. Chem. 4(6): 859-
67.
172. Bourne Y, Redford SM, Steinman HM, Lepock JR, Tainer JA, Getzoff ED. (1996)
Novel dimeric interface and electrostatic recognition in bacterial cu,zn superoxide
dismutase. Proc. Natl. Acad. Sci. U. S. A. 93(23): 12774-9.
173. Bruick RK, Dawson PE, Kent SB, Usman N, Joyce GF. (1996) Template-directed
ligation of peptides to oligonucleotides. Chem. Biol. 3(1): 49-56.
174. Canne LE, Bark SJ, Kent SBH. (1996) Extending the applicability of native
chemical ligation. J. Am. Chem. Soc. 118(25): 5891-6.
175. Celia H, Jontes JD, Whittaker M, Milligan RA. (1996) Two-dimensional
crystallization of brush border myosin i. J. Struct. Biol. 117(3): 236-41.
176. Chang HT, Chen CT, Kondo T, Siuzdak G, Sharpless KB. (1996) Asymmetric
dihydroxylation enables rapid construction of chiral dendrimers based on 1,2-diols.
Angew. Chem.-Int. Edit. 35(2): 182-6.
177. Chang HT, Sharpless KB. (1996) Molar scale synthesis of enantiopure stilbene
oxide. J. Org. Chem. 61(18): 6456-7.
178. Chang HT, Sharpless KB. (1996) A practical route to enantiopure 1,2aminoalcohols.
Tetrahedron Lett. 37(19): 3219-22.
179. Cheng S, Tarby CM, Comer DD, Williams JP, Caporale LH, Myers PL, Boger DL.
(1996) A solution-phase strategy for the synthesis of chemical libraries containing small
organic molecules: A universal and dipeptide mimetic template. Bioorg. Med. Chem.
4(5): 727-37.
180. Crane BR, Getzoff ED. (1996) The relationship between structure and function for

the sulfite reductases. Curr. Opin. Struct. Biol. 6(6): 744-56.
181. Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB. (1996)
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid
amides. Nature. 384(6604): 83-7.
182. Cravatt BF, Lerner RA, Boger DL. (1996) Structure determination of an
endogenous sleep-inducing lipid, cis-9-octadecenamide (oleamide): A synthetic
approach to the chemical analysis of trace quantities of a natural product. J. Am. Chem.
Soc. 118(3): 580-90.
183. Garcia KC, Scott CA, Brunmark A, Carbone FR, Peterson PA, Wilson IA, Teyton
L. (1996) Cd8 enhances formation of stable t-cell receptor mhc class i molecule
complexes. Nature. 384(6609): 577-81.
184. Gurbiel RJ, Doan PE, Gassner GT, Macke TJ, Case DA, Ohnishi T, Fee JA,
Ballou DP, Hoffman BM. (1996) Active site structure of rieske-type proteins: Electron
nuclear double resonance studies of isotopically labeled phthalate dioxygenase from
pseudomonas cepacia and rieske protein from rhodobacter caysulatus and molecular
modeling studies of a rieske cente. Biochemistry. 35(24): 7834-45.
185. Guy RK, Scott ZA, Sloboda RD, Nicolaou KC. (1996) Fluorescent taxoids. Chem.
Biol. 3(12): 1021-31.
186. Habata Y, Bradshaw JS, Young JJ, Castle SL, Huszthy P, Pyo T, Lee ML, Izatt
RM. (1996) New pyridino-18-crown-6 ligands containing two methyl, two tert-butyl, or
two allyl substituents on chiral positions next to the pyridine ring. J. Org. Chem. 61(24):
8391-6.
187. Hartgerink JD, Granja JR, Milligan RA, Ghadiri MR. (1996) Self-assembling
peptide nanotubes. J. Am. Chem. Soc. 118(1): 43-50.
188. Haynes MR, Heine A, Wilson IA. (1996) Catalytic antibody structures: An early
assessment. Isr. J. Chem. 36(2): 133-42.
189. Haynes MR, Lenz M, Taussig MJ, Wilson IA, Hilvert D. (1996) Sequence
similarity and cross-reactivity of a diels-alder catalyst and an anti-progesterone
antibody. Isr. J. Chem. 36(2): 151-9.
190. Hendrix M, Wong CH. (1996) A chemo-enzymatic approach to the study of
carbohydrate recognition in biological systems. Enantiomer. 1(4-6): 305-10.
191. Hendrix M, Wong CH. (1996) A chemoenzymatic approach to carbohydratemediated
cell adhesion. Pure Appl. Chem. 68(11): 2081-7.
192. Hirst JD, Vieth M, Skolnick J, Brooks CL. (1996) Predicting leucine zipper
structures from sequence. Protein Eng. 9(8): 657-62.
193. Hiruma K, Kajimoto T, WeitzSchmidt G, Ollmann I, Wong CH. (1996) Rational
design and synthesis of a 1,1-linked disaccharide that is 5 times as active as sialyl lewis
x in binding to e-selectin. J. Am. Chem. Soc. 118(39): 9265-70.
194. Hu TH, Guan TL, Gerace L. (1996) Molecular and functional characterization of
the p62 complex, an assembly of nuclear pore complex glycoproteins. J. Cell Biol.
134(3): 589-601.
195. Huang JF, Teyton L, Harper JF. (1996) Activation of a ca2+-dependent protein
kinase involves intramolecular binding of a calmodulin-like regulatory domain.
Biochemistry. 35(40): 13222-30.

196. Jeong JH, Murray BW, Takayama S, Wong CH. (1996) Cyclic guanidino-sugars
with low pk(a) as transition-state analog inhibitors of glycosidases: Neutral instead of
charged species are the active forms. J. Am. Chem. Soc. 118(18): 4227-34.
197. Kast P, Hartgerink JD, AsifUllah M, Hilvert D. (1996) Electrostatic catalysis of the
claisen rearrangement: Probing the role of glu78 in bacillus subtilis chorismate mutase
by genetic selection. J. Am. Chem. Soc. 118(12): 3069-70.
198. Kidd RD, Yennawar HP, Sears P, Wong CH, Farber GK. (1996) A weak calcium
binding site in subtilisin bpn' has a dramatic effect on protein stability. J. Am. Chem.
Soc. 118(7): 1645-50.
199. Kimura T, Takayama S, Huang HM, Wong CH. (1996) A practical method for the
synthesis of n-acetyl-d-lactosamine derivatives by the tandem use of galactose oxidase
and beta-galactosidase. Angew. Chem.-Int. Edit. 35(20): 2348-50.
200. Lee DH, Granja JR, Martinez JA, Severin K, Ghadiri MR. (1996) A self-replicating
peptide. Nature. 382(6591): 525-8.
201. Li GG, Chang HT, Sharpless KB. (1996) Catalytic asymmetric
aminohydroxylation (aa) of olefins. Angew. Chem.-Int. Edit. 35(4): 451-4.
202. Lin CC, Kimura T, Wu SH, WeitzSchmidt G, Wong CH. (1996) Liposome-like
fucopeptides as sialyl lewis x mimetics. Bioorg. Med. Chem. Lett. 6(22): 2755-60.
203. Lin CC, Shimazaki M, Heck MP, Aoki S, Wang R, Kimura T, Ritzen H, Takayama
S, Wu SH, WeitzSchmidt G, Wong CH. (1996) Synthesis of sialyl lewis x mimetics and
related structures using the glycosyl phosphite methodology and evaluation of e-selectin
inhibition. J. Am. Chem. Soc. 118(29): 6826-40.
204. Lo CHL, Gao CS, Mao SL, Matsui K, Lerner RA, Janda KD. (1996) Chain
shuffling: Investigations into the specificity and selectivity of antibody catalysis. Isr. J.
Chem. 36(2): 195-8.
205. Lo LC, Lo CHL, Janda KD, Kassel DB, Raushel FM. (1996) A versatile
mechanism based reaction probe for the direct selection of biocatalysts. Bioorg. Med.
Chem. Lett. 6(17): 2117-20.
206. MacBeath G, Hilvert D. (1996) Hydrolytic antibodies: Variations on a theme.
Chem. Biol. 3(6): 433-45.
207. Muir TW, Dawson PE, Fitzgerald MC, Kent SBH. (1996) Probing the chemical
basis of binding activity in an sh3 domain by protein signature analysis. Chem. Biol.
3(10): 817-25.
208. Murray BW, Takayama S, Schultz J, Wong CH. (1996) Mechanism and
specificity of human alpha-1,3-fucosyltransferase v. Biochemistry. 35(34): 11183-95.
209. Nicolaou KC, Gross JL, Kerr MA. (1996) Synthesis of novel heterocycles related
to the dynemicin a ring skeleton. J. Heterocycl. Chem. 33(3): 735-46.
210. Nicolaou KC, Guy RK, Potier P. (1996) Taxoids: New weapons against cancer.
Sci.Am. 274(6): 94-8.
211. Nicolaou KC, He Y, Vourloumis D, Vallberg H, Yang Z. (1996) An approach to
epothilones based on olefin metathesis. Angew. Chem.-Int. Edit. 35(20): 2399-401.
212. Nicolaou KC, Postema MHD, Claiborne CF. (1996) Olefin metathesis in cyclic
ether formation. Direct conversion of olefinic esters to cyclic enol ethers with tebbe-type
reagents. J. Am. Chem. Soc. 118(6): 1565-6.

213. Nicolaou KC, Postema MHD, Yue EW, Nadin A. (1996) An olefin metathesis
based strategy for the construction of the jkl, opq, and uvw ring systems of maitotoxin. J.
Am. Chem. Soc. 118(42): 10335-6.
214. Nicolaou KC, Sato M, Miller ND, Gunzner JL, Renaud J, Untersteller E. (1996)
Copper(i)-promoted stille cross-coupling of stannyl enol ethers with enol triflates:
Construction of complex polyether frameworks. Angew. Chem.-Int. Edit. 35(8): 889-91.
215. Nicolaou KC, Theodorakis EA, Claiborne CF. (1996) Chemistry and biology of
selected natural products. Pure Appl. Chem. 68(11): 2129-36.
216. Ogihara NL, Parge HE, Hart PJ, Weiss MS, Goto JJ, Crane BR, Tsang J, Slater
K, Roe JA, Valentine JS, Eisenberg D, Tainer JA. (1996) Unusual trigonal-planar copper
configuration revealed in the atomic structure of yeast copper-zinc superoxide
dismutase. Biochemistry. 35(7): 2316-21.
217. Orsat B, Alper PB, Moree W, Mak CP, Wong CH. (1996) Homocarbonates as
substrates for the enantioselective enzymatic protection of amines. J. Am. Chem. Soc.
118(3): 712-3.
218. Patterson JE, Ollmann IR, Cravatt BF, Boger DL, Wong CH, Lerner RA. (1996)
Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing
lipid cis-9-octadecenamide. J. Am. Chem. Soc. 118(25): 5938-45.
219. Roben P, Barbas SM, Sandoval L, Lecerf JM, Stollar BD, Solomon A, Silverman
GJ. (1996) Repertoire cloning of lupus anti-DNA autoantibodies. J. Clin. Invest. 98(12):
2827-37.
220. Rosenblum JS, Gilula NB, Lerner RA. (1996) On signal sequence polymorphisms
and diseases of distribution. Proc. Natl. Acad. Sci. U. S. A. 93(9): 4471-3.
221. Scott CA, Garcia KC, Carbone FR, Wilson IA, Teyton L. (1996) Role of chain
pairing for the production of functional soluble ia major histocompatibility complex class
ii molecules. J. Exp. Med. 183(5): 2087-95.
222. Sears P, Wong CH. (1996) Engineering enzymes for bioorganic synthesis:
Peptide bond formation. Biotechnol. Progr. 12(4): 423-33.
223. Sears P, Wong CH. (1996) Intervention of carbohydrate recognition by proteins
and nucleic acids. Proc. Natl. Acad. Sci. U. S. A. 93(22): 12086-93.
224. Smith JA, GomezPaloma L, Case DA, Chazin WJ. (1996) Molecular dynamics
docking driven by nmr-derived restraints to determine the structure of the calicheamicin
gamma(i)(1) oligosaccharide domain complexed to duplex DNA. Magn. Reson. Chem.
34: S147-S55.
225. Takayama S, Livingston PO, Wong CH. (1996) Synthesis of the melanomaassociated
ganglioside 9-o-acetyl gd3 through regioselective enzymatic acetylation of
gd3 using subtilisin. Tetrahedron Lett. 37(52): 9271-4.
226. Takayama S, Moree WJ, Wong CH. (1996) Enzymatic resolution of amines and
amino alcohols using pent-4-enoyl derivatives. Tetrahedron Lett. 37(35): 6287-90.
227. Takayama S, Shimazaki M, Qiao L, Wong CH. (1996) Synthesis of lactosamine
derivatives using beta-d-galactosidase from bacillus circulans. Bioorg. Med. Chem. Lett.
6(10): 1123-6.
228. Tang Y, Jiang N, Parakh C, Hilvert D. (1996) Selection of linkers for a catalytic
single-chain antibody using phage display technology. J. Biol. Chem. 271(26): 15682-6.

229. Tsang J, Joyce GF. (1996) Specialization of the DNA-cleaving activity of a group
i ribozyme through in vitro evolution. J. Mol. Biol. 262(1): 31-42.
230. Tsang J, Joyce GF. (1996) In vitro evolution of randomized ribozymes. Methods
Enzymol. 267: 410-26.
231. Uchiyama T, Woltering TJ, Wong WC, Lin CC, Kajimoto T, Takebayashi M,
WeitzSchmidt G, Asakura T, Noda M, Wong CH. (1996) Design and synthesis of clinked
fucosides as inhibitors of e-selectin. Bioorg. Med. Chem. 4(7): 1149-65.
232. Vieth M, Kolinski A, Skolnick J. (1996) Method for predicting the state of
association of discretized protein models. Application to leucine zippers. Biochemistry.
35(3): 955-67.
233. Wang R, Wong CH. (1996) Synthesis of sialyl lewis x mimetics: Use of o-alphafucosyl-(1r,
2r)-2-aminocyclohexanol as core structure. Tetrahedron Lett. 37(31): 5427-
30.
234. Wilcox SK, Jensen GM, Fitzgerald MM, McRee DE, Goodin DB. (1996) Altering
substrate specificity at the heme edge of cytochrome c peroxidase. Biochemistry.
35(15): 4858-66.
235. Wu L, Shiozaki K, Aligue R, Russell P. (1996) Spatial organization of the nim1wee1-cdc2
mitotic control network in schizosaccharomyces pombe. Mol. Biol. Cell.
7(11): 1749-58.
236. Wu SH, Shimazaki M, Lin CC, Qiao L, Moree WJ, WeitzSchmidt G, Wong CH.
(1996) Synthesis of fucopeptides as sialyl lewis(x) mimetics. Angew. Chem.-Int. Edit.
35(1): 88-90.
237. Xu K, Clark D, Strauch MA. (1996) Analysis of abrb mutations, mutant proteins,
and why abrb does not utilize a perfect consensus in the -35 region of its sigma(a)
promoter. J. Biol. Chem. 271(5): 2621-6.
238. YliKauhaluoma JT, Ashley JA, Lo CHL, Coakley J, Wirsching P, Janda KD.
(1996) Catalytic antibodies with peptidyl-prolyl cis-trans isomerase activity. J. Am.
Chem. Soc. 118(23): 5496-7.
239. Yohn CB, Cohen A, Danon A, Mayfield SP. (1996) Altered mrna binding activity
and decreased translation initiation in a nuclear mutant lacking translation of the
chloroplast psba mrna. Mol. Cell. Biol. 16(7): 3560-6.
240. Aligue R, Wu L, Russell P. (1997) Regulation of schizosaccharomyces pombe
wee1 tyrosine kinase. J. Biol. Chem. 272(20): 13320-5.
241. Baca M, Presta LG, Oconnor SJ, Wells JA. (1997) Antibody humanization using
monovalent phage display. J. Biol. Chem. 272(16): 10678-84.
242. Baca M, Scanlan TS, Stephenson RC, Wells JA. (1997) Phage display of a
catalytic antibody to optimize affinity for transition-state analog binding. Proc. Natl.
Acad. Sci. U. S. A. 94(19): 10063-8.
243. Balicki D, Beutler E. (1997) Histone h2a significantly enhances in vitro DNA
transfection. Mol. Med. 3(11): 782-7.
244. Baran PS, Monaco RR, Khan AU, Schuster DI, Wilson SR. (1997) Synthesis and
cation-mediated electronic interactions of two novel classes of porphyrin-fullerene
hybrids. J. Am. Chem. Soc. 119(35): 8363-4.
245. Barbas CF, Heine A, Zhong GF, Hoffmann T, Gramatikova S, Bjornestedt R, List

B, Anderson J, Stura EA, Wilson IA, Lerner RA. (1997) Immune versus natural
selection: Antibody aldolases with enzymic rates but broader scope. Science.
278(5346): 2085-92.
246. Bashford D, Case DA, Choi C, Gippert GP. (1997) Computational study of the
role of solvation effects in reverse turn formation in the tetrapeptides apgd and apgn. J.
Am. Chem. Soc. 119(21): 4964-71.
247. Boger DL, Bollinger B, Hertzog DL, Johnson DS, Cai H, Mesini P, Garbaccio RM,
Jin Q, Kitos PA. (1997) Reversed and sandwiched analogs of duocarmycin sa:
Establishment of the origin of the sequence-selective alkylation of DNA and new
insights into the source of catalysis. J. Am. Chem. Soc. 119(21): 4987-98.
248. Boger DL, Boyce CW, Garbaccio RM, Goldberg JA. (1997) Cc-1065 and the
duocarmycins: Synthetic studies. Chem. Rev. 97(3): 787-828.
249. Boger DL, Boyce CW, Johnson DS. (1997) Ph dependence of the rate of DNA
alkylation for (+)-duocarmycin sa and (+)-ccbi-tmi. Bioorg. Med. Chem. Lett. 7(2): 233-8.
250. Boger DL, Chai WY, Ozer RS, Andersson CM. (1997) Solution-phase
combinatorial synthesis via the olefin metathesis reaction. Bioorg. Med. Chem. Lett.
7(4): 463-8.
251. Boger DL, Garbaccio RM. (1997) Catalysis of the cc-1065 and duocarmycin DNA
alkylation reaction: DNA binding induced conformational change in the agent results in
activation. Bioorg. Med. Chem. 5(2): 263-76.
252. Boger DL, Garbaccio RM, Jin Q. (1997) Synthesis and evaluation of cc-1065 and
duocarmycin analogues incorporating the iso-ci and iso-cbi alkylation subunits: Impact
of relocation of the c-4 carbonyl. J. Org. Chem. 62(25): 8875-91.
253. Boger DL, Haynes NE, Kitos PA, Warren MS, Ramcharan J, Marolewski AE,
Benkovic SJ. (1997) 10-formyl-5,8,10-trideazafolic acid (10-formyl-tdaf): A potent
inhibitor of glycinamide ribonucleotide transformylase. Bioorg. Med. Chem. 5(9): 1817-
30.
254. Boger DL, Haynes NE, Warren MS, Gooljarsingh LT, Ramcharan J, Kitos PA,
Benkovic SJ. (1997) Functionalized analogues of 5,8,10-trideazafolate as potential
inhibitors of gar tfase or aicar tfase. Bioorg. Med. Chem. 5(9): 1831-8.
255. Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ. (1997)
Functionalized analogues of 5,8,10-trideazafolate: Development of an enzymeassembled
tight binding inhibitor of gar tfase and a potential irreversible inhibitor of aicar
tfase. Bioorg. Med. Chem. 5(9): 1839-46.
256. Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ. (1997)
Multisubstrate analogue based on 5,8,10-trideazafolate. Bioorg. Med. Chem. 5(9): 1853-
7.
257. Boger DL, Haynes NE, Warren MS, Ramcharan J, Marolewski AE, Kitos PA,
Benkovic SJ. (1997) Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-tdaf): An
effective inhibitor of glycinamide ribonucleotide transformylase. Bioorg. Med. Chem.
5(9): 1847-52.
258. Boger DL, Hertzog DL, Bollinger B, Johnson DS, Cai H, Goldberg J, Turnbull P.
(1997) Duocarmycin sa shortened, simplified, and extended agents: A systematic
examination of the role of the DNA binding subunit. J. Am. Chem. Soc. 119(21): 4977-

86.
259. Boger DL, Hikota M, Lewis BM. (1997) Determination of the relative and absolute
stereochemistry of fostriecin (ci-920). J. Org. Chem. 62(6): 1748-53.
260. Boger DL, Loiseleur O, Castle SL, Beresis RT, Wu JH. (1997) Thermal
atropisomerism of fully functionalized vancomycin cd, de, and cde ring systems. Bioorg.
Med. Chem. Lett. 7(24): 3199-202.
261. Boger DL, McKie JA, Boyce CW. (1997) Asymmetric synthesis of the cbi
alkylation subunit of the cc-1065 and duocarmycin analogs. Synlett. (5): 515-+.
262. Boger DL, Ozer RS, Andersson CM. (1997) Generation of targeted c-2symmetrical
compound libraries by solution-phase combinatorial chemistry. Bioorg.
Med. Chem. Lett. 7(14): 1903-8.
263. Boger DL, Teramoto S, Cai H. (1997) N-methyl threonine analogues of
deglycobleomycin a(2): Synthesis and evaluation. Bioorg. Med. Chem. 5(8): 1577-89.
264. Boger DL, Zhou JC, Borzilleri RM, Nukui S, Castle SL. (1997) Synthesis of
(9r,12s)- and (9s,12s)-cycloisodityrosine and their n-methyl derivatives. J. Org. Chem.
62(7): 2054-69.
265. Bruick RK, Koppitz M, Joyce GF, Orgel LE. (1997) A simple procedure for
constructing 5'-amino-terminated oligodeoxynucleotides in aqueous solution. Nucleic
Acids Res. 25(6): 1309-10.
266. Burkart MD, Zhang ZY, Hung SC, Wong CH. (1997) A new method for the
synthesis of fluoro-carbohydrates and glycosides using selectfluor. J. Am. Chem. Soc.
119(49): 11743-6.
267. Canne LE, Winston RL, Kent SBH. (1997) Synthesis of a versatile purification
handle for use with boc chemistry solid phase peptide synthesis. Tetrahedron Lett.
38(19): 3361-4.
268. Crane BR, Arvai AS, Gachhui R, Wu CQ, Ghosh DK, Getzoff ED, Stuehr DJ,
Tainer JA. (1997) The structure of nitric oxide synthase oxygenase domain and inhibitor
complexes. Science. 278(5337): 425-31.
269. Crane BR, Bellamy H, Getzoff ED. (1997) Multiwavelength anomalous diffraction
of sulfite reductase hemoprotein: Making the most of mad data. Acta Crystallogr. Sect.
D-Biol. Crystallogr. 53: 8-22.
270. Crane BR, Getzoff ED. (1997) Determining phases and anomalous scattering
models from the multiwavelength anomalous diffraction of native protein metal clusters.
Improved mad phase error estimates and anomalous-scatterer positions. Acta
Crystallogr. Sect. D-Biol. Crystallogr. 53: 23-40.
271. Crane BR, Siegel LM, Getzoff ED. (1997) Structures of the siroheme- and fe4s4containing
active center of sulfite reductase in different states of oxidation: Heme
activation via reduction-gated exogenous ligand exchange. Biochemistry. 36(40):
12101-19.
272. Crane BR, Siegel LM, Getzoff ED. (1997) Probing the catalytic mechanism of
sulfite reductase by x-ray crystallography: Structures of the escherichia coli hemoprotein
in complex with substrates, inhibitors, intermediates, and products. Biochemistry.
36(40): 12120-37.
273. Dawson PE. (1997) Synthesis of chemokines by native chemical ligation.

Methods Enzymol. 287: 34-45.
274. Dawson PE, Churchill MJ, Ghadiri MR, Kent SBH. (1997) Modulation of reactivity
in native chemical ligation through the use of thiol additives. J. Am. Chem. Soc. 119(19):
4325-9.
275. Dawson PE, Fitzgerald MC, Muir TW, Kent SBH. (1997) Methods for the
chemical synthesis and readout of self-encoded arrays of polypeptide analogues. J. Am.
Chem. Soc. 119(34): 7917-27.
276. deFonseca FR, Carrera MRA, Navarro M, Koob GF, Weiss F. (1997) Activation
of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal.
Science. 276(5321): 2050-4.
277. DelMonte AJ, Haller J, Houk KN, Sharpless KB, Singleton DA, Strassner T,
Thomas AA. (1997) Experimental and theoretical kinetic isotope effects for asymmetric
dihydroxylation. Evidence supporting a rate-limiting ''(3+2)'' cycloaddition. J. Am. Chem.
Soc. 119(41): 9907-8.
278. Demchuk E, Bashford D, Gippert GP, Case DA. (1997) Thermodynamics of a
reverse turn motif. Solvent effects and side-chain packing. J. Mol. Biol. 270(2): 305-17.
279. Devanathan S, Genick UK, Getzoff ED, Meyer TE, Cusanovich MA, Tollin G.
(1997) Preparation and properties of a 3,4-dihydroxycinnamic acid chromophore variant
of the photoactive yellow protein. Arch. Biochem. Biophys. 340(1): 83-9.
280. Dobrosotskaya I, Guy RK, James GL. (1997) Magi-1, a membrane-associated
guanylate kinase with a unique arrangement of protein-protein interaction domains. J.
Biol. Chem. 272(50): 31589-97.
281. Doyle TJ, Hendrix M, VanDerveer D, Javanmard S, Haseltine J. (1997) A
convergent synthesis of (+)-pancratistatin based on intramolecular electrophilic aromatic
substitution. Tetrahedron. 53(32): 11153-70.
282. Eis PS, Smith JA, Rydzewski JM, Case DA, Boger DL, Chazin WJ. (1997) High
resolution solution structure of a DNA duplex alkylated by the antitumor agent
duocarmycin sa. J. Mol. Biol. 272(2): 237-52.
283. Freyaldenhoven BS, Freyaldenhoven MP, Iacovoni JS, Vogt PK. (1997) Aberrant
cell growth induced by avian winged helix proteins. Cancer Res. 57(1): 123-9.
284. Freyaldenhoven BS, Freyaldenhoven MP, Iacovoni JS, Vogt PK. (1997) Avian
winged helix proteins cwh-1, cwh-2 and cwh-3 repress transcription from qin binding
sites. Oncogene. 15(4): 483-8.
285. Furnari B, Rhind N, Russell P. (1997) Cdc25 mitotic inducer targeted by chk1
DNA damage checkpoint kinase. Science. 277(5331): 1495-7.
286. Furnari BA, Russell P, Leatherwood J. (1997) Pch1(+), a second essential c-type
cyclin gene in schizosaccharomyces pombe. J. Biol. Chem. 272(18): 12100-6.
287. Gachhui R, Ghosh DK, Wu CQ, Parkinson J, Crane BR, Stuehr DJ. (1997)
Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide
synthase identifies a glutamate involved in arginine binding. Biochemistry. 36(17): 5097-
103.
288. Gao CS, Lin CH, Lo CHL, Mao S, Wirsching P, Lerner RA, Janda KD. (1997)
Making chemistry selectable by linking it to infectivity. Proc. Natl. Acad. Sci. U. S. A.
94(22): 11777-82.

289. Garcia KC, Tallquist MD, Pease LR, Brunmark A, Scott CA, Degano M, Stura EA,
Peterson PA, Wilson IA, Teyton L. (1997) Alpha beta t cell receptor interactions with
syngeneic and allogeneic ligands: Affinity measurements and crystallization. Proc. Natl.
Acad. Sci. U. S. A. 94(25): 13838-43.
290. Genick UK, Borgstahl GEO, Ng K, Ren Z, Pradervand C, Burke PM, Srajer V,
Teng TY, Schildkamp W, McRee DE, Moffat K, Getzoff ED. (1997) Structure of a protein
photocycle intermediate by millisecond time-resolved crystallography. Science.
275(5305): 1471-5.
291. Genick UK, Devanathan S, Meyer TE, Canestrelli IL, Williams E, Cusanovich MA,
Tollin G, Getzoff ED. (1997) Active site mutants implicate key residues for control of
color and light cycle kinetics of photoactive yellow protein. Biochemistry. 36(1): 8-14.
292. Ghiara JB, Ferguson DC, Satterthwait AC, Dyson HJ, Wilson IA. (1997)
Structure-based design of a constrained peptide mimic of the hiv-1 v3 loop
neutralization site. J. Mol. Biol. 266(1): 31-9.
293. Giang DK, Cravatt BF. (1997) Molecular characterization of human and mouse
fatty acid amide hydrolases. Proc. Natl. Acad. Sci. U. S. A. 94(6): 2238-42.
294. Gong X, Kaushal S, Ceccarelli E, Bogdanova N, Neville C, Nguyen T, Clark H,
Khatib ZA, Valentine M, Look AT, Rosenthal N. (1997) Developmental regulation of
zbu1, a DNA-binding member of the swi2/snf2 family. Dev. Biol. 183(2): 166-82.
295. Gong XH, Li E, Klier G, Huang QL, Wu Y, Lei H, Kumar NM, Horwitz J, Gilula NB.
(1997) Disruption of alpha(3) connexin gene leads to proteolysis and cataractogenesis
in mice. Cell. 91(6): 833-43.
296. Guan XJ, Cravatt BF, Ehring CR, Hall JE, Boger DL, Lerner RA, Gilula NB.
(1997) The sleep-inducing lipid oleamide deconvolutes gap junction communication and
calcium wave transmission in glial cells. J. Cell Biol. 139(7): 1785-92.
297. Hayashi T, Murray BW, Wang R, Wong CH. (1997) A chemoenzymatic synthesis
of udp-(2-deoxy-2-fluoro)galactose and evaluation of its interaction with
galactosyltransferase. Bioorg. Med. Chem. 5(3): 497-500.
298. Hendrix M, Alper PB, Priestley ES, Wong CH. (1997) Hydroxyamines as a new
motif for the molecular recognition of phosphodiesters: Implications for aminoglycosiderna
interactions. Angew. Chem.-Int. Edit. 36(1-2): 95-8.
299. Hendrix M, Priestley ES, Joyce GF, Wong CH. (1997) Direct observation of
aminoglycoside-rna interactions by surface plasmon resonance. J. Am. Chem. Soc.
119(16): 3641-8.
300. Huang JF. (1997) Counting characters in blocks of m-22. J. Algebra. 191(1): 1-
75.
301. Hung SC, Lin CC, Wong CH. (1997) One-pot synthesis of 1-allyl- and 1-allenyl-6o-acetyl-2,3,4-tri-o-benzyl-alpha-d-glycosides
from methyl tetra-o-benzyl-alpha-dglycosides.
Tetrahedron Lett. 38(31): 5419-22.
302. Janda KD, Lo LC, Lo CHL, Sim MM, Wang R, Wong CH, Lerner RA. (1997)
Chemical selection for catalysis in combinatorial antibody libraries. Science. 275(5302):
945-8.
303. Jontes JD, Milligan RA. (1997) Brush border myosin-i structure and adpdependent
conformational changes revealed by cryoelectron microscopy and image

analysis. J. Cell Biol. 139(3): 683-93.
304. Jontes JD, Milligan RA. (1997) Three-dimensional structure of brush border
myosin-i at similar to 20 angstrom resolution by electron microscopy and image
analysis. J. Mol. Biol. 266(2): 331-42.
305. Jontes JD, Milligan RA, Pollard TD, Ostap EM. (1997) Kinetic characterization of
brush border myosin-i atpase. Proc. Natl. Acad. Sci. U. S. A. 94(26): 14332-7.
306. Kruse U, Iacovoni JS, Goller ME, Vogt PK. (1997) Hormone-regulatable
neoplastic transformation induced by a jun-estrogen receptor chimera. Proc. Natl. Acad.
Sci. U. S. A. 94(23): 12396-400.
307. Lee DH, Severin K, Ghadiri MR. (1997) Autocatalytic networks: The transition
from molecular self-replication to molecular ecosystems. Curr. Opin. Chem. Biol. 1(4):
491-6.
308. Lee DH, Severin K, Yokobayashi Y, Ghadiri MR. (1997) Emergence of symbiosis
in peptide self-replication through a hypercyclic network. Nature. 390(6660): 591-4.
309. Li J, Thurm H, Chang HW, Iacovoni JS, Vogt PK. (1997) Oncogenic
transformation induced by the qin protein is correlated with transcriptional repression.
Proc. Natl. Acad. Sci. U. S. A. 94(20): 10885-8.
310. Li TH, Weinstein DS, Nicolaou KC. (1997) The chemical end-ligation of
homopyrimidine oligodeoxyribonucleotides within a DNA triple helix. Chem. Biol. 4(3):
209-14.
311. Lin CC, Lin CH, Wong CH. (1997) Sialic acid aldolase-catalyzed condensation of
pyruvate and n-substituted mannosamine: A useful method for the synthesis of nsubstituted
sialic acids. Tetrahedron Lett. 38(15): 2649-52.
312. Lin CH, Murray BW, Ollmann IR, Wong CH. (1997) Why is cmpketodeoxyoctonate
highly unstable? Biochemistry. 36(4): 780-5.
313. Liu Q, Segal DJ, Ghiara JB, Barbas CF. (1997) Design of polydactyl zinc-finger
proteins for unique addressing within complex genomes. Proc. Natl. Acad. Sci. U. S. A.
94(11): 5525-30.
314. Lo CHL, Wentworth P, Jung KW, Yoon J, Ashley JA, Janda KD. (1997) Reactive
immunization strategy generates antibodies with high catalytic proficiencies. J. Am.
Chem. Soc. 119(42): 10251-2.
315. Manchester M, Gairin JE, Patterson JE, Alvarez J, Liszewski MK, Eto DS,
Atkinson JP, Oldstone MBA. (1997) Measles virus recognizes its receptor, cd46, via two
distinct binding domains within scr1-2. Virology. 233(1): 174-84.
316. Moree WJ, Sears P, Kawashiro K, Witte K, Wong CH. (1997) Exploitation of
subtilisin bpn' as catalyst for the synthesis of peptides containing noncoded amino
acids, peptide mimetics and peptide conjugates. J. Am. Chem. Soc. 119(17): 3942-7.
317. Muhlberg AB, Warnock DE, Schmid SL. (1997) Domain structure and
intramolecular regulation of dynamin gtpase. Embo J. 16(22): 6676-83.
318. Muir TW, Dawson PE, Fitzgerald MC, Kent SBH. (1997) Protein signature
analysis: A practical new approach for studying structure-activity relationships in
peptides and proteins. Methods Enzymol. 289: 545-64.
319. Muir TW, Dawson PE, Kent SBH. (1997) Protein synthesis by chemical ligation of
unprotected peptides in aqueous solution. Methods Enzymol. 289: 266-98.

320. Murray BW, Wittmann V, Burkart MD, Hung SC, Wong CH. (1997) Mechanism of
human alpha-1,3-fucosyltransferase v: Glycosidic cleavage occurs prior to nucleophilic
attack. Biochemistry. 36(4): 823-31.
321. Musah RA, Jensen GM, Rosenfeld RJ, McRee DE, Goodin DB, Bunte SW.
(1997) Variation in strength of an unconventional c-h to o hydrogen bond in an
engineered protein cavity. J. Am. Chem. Soc. 119(38): 9083-4.
322. Navarro M, Hernandez E, Munoz RM, delArco I, Villanua MA, Carrera MRA,
deFonseca FR. (1997) Acute administration of the cb1 cannabinoid receptor antagonist
sr 141716a induces anxiety-like responses in the rat. Neuroreport. 8(2): 491-6.
323. Nelson DW, Gypser A, Ho PT, Kolb HC, Kondo T, Kwong HL, McGrath DV,
Rubin AE, Norrby PO, Gable KP, Sharpless KB. (1997) Toward an understanding of the
high enantioselectivity in the osmium-catalyzed asymmetric dihydroxylation .4.
Electronic effects in amine-accelerated osmylations. J. Am. Chem. Soc. 119(8): 1840-
58.
324. Nicolaou KC, Boddy CNC, Natarajan S, Yue TY, Li H, Brase S, Ramanjulu JM.
(1997) New synthetic technology for the synthesis of aryl ethers: Construction of c-o-d
and d-o-e ring model systems of vancomycin. J. Am. Chem. Soc. 119(14): 3421-2.
325. Nicolaou KC, Chu XJ, Ramanjulu JM, Natarajan S, Brase S, Rubsam F, Boddy
CNC. (1997) New technology for the synthesis of vancomycin-type biaryl ring systems.
Angew. Chem.-Int. Edit. 36(13-14): 1539-40.
326. Nicolaou KC, Claiborne CF, Paulvannan K, Postema MHD, Guy RK. (1997) The
chemical synthesis of c-ring aryl taxoids. Chem.-Eur. J. 3(3): 399-409.
327. Nicolaou KC, He Y, Vourloumis D, Vallberg H, Roschangar F, Sarabia F,
Ninkovic S, Yang Z, Trujillo JI. (1997) The olefin metathesis approach to epothilone a
and its analogues. J. Am. Chem. Soc. 119(34): 7960-73.
328. Nicolaou KC, Ninkovic S, Sarabia F, Vourloumis D, He Y, Vallberg H, Finlay
MRV, Yang Z. (1997) Total syntheses of epothilones a and b via a macrolactonizationbased
strategy. J. Am. Chem. Soc. 119(34): 7974-91.
329. Nicolaou KC, Ramanjulu JM, Natarajan S, Brase S, Li H, Boddy CNC, Rubsam F.
(1997) A suzuki coupling-macrolactamization approach to the ab-cod bicyclic system of
vancomycin. Chem. Commun. (19): 1899-900.
330. Nicolaou KC, Sarabia F, Finlay MRV, Ninkovic S, King NP, Vourloumis D, He Y.
(1997) Total synthesis of oxazole- and cyclopropane-containing epothilone b analogues
by the macrolactonization approach. Chem.-Eur. J. 3(12): 1971-86.
331. Nicolaou KC, Shi GQ, Gunzner JL, Gartner P, Yang Z. (1997) Palladiumcatalyzed
functionalization of lactones via their cyclic ketene acetal phosphates.
Efficient new synthetic technology for the construction of medium and large cyclic
ethers. J. Am. Chem. Soc. 119(23): 5467-8.
332. Nicolaou KC, Smith BM, Pastor J, Watanabe Y, Weinstein DS. (1997) Synthesis
of DNA-binding oligosaccharides. Synlett. (5): 401-+.
333. Nicolaou KC, Trujillo JI, Chibale K. (1997) Design, synthesis and biological
evaluation of carbohydrate-based mimetics of crgdfv. Tetrahedron. 53(26): 8751-78.
334. Nicolaou KC, Vallberg H, King NP, Roschangar F, He Y, Vourloumis D, Nicolaou
CG. (1997) Total synthesis of oxazole- and cyclopropane-containing epothilone a

analogues by the olefin metathesis approach. Chem.-Eur. J. 3(12): 1957-70.
335. Nicolaou KC, vanDelft F, Ohshima T, Vourloumis D, Xu JY, Hosokawa S,
Pfefferkorn J, Kim S, Li TH. (1997) Total synthesis of eleutherobin. Angew. Chem.-Int.
Edit. 36(22): 2520-4.
336. Nicolaou KC, vanDelft FL, Conley SR, Mitchell HJ, Jin Z, Rodriguez RM. (1997)
New synthetic technology for the stereocontrolled construction of 1,1'-disaccharides and
1,1':1'',2-trisaccharides. Synthesis of the fg ring system of everninomicin 13,384-1. J.
Am. Chem. Soc. 119(38): 9057-8.
337. Nicolaou KC, Vourloumis D, Li TH, Pastor J, Winssinger N, He Y, Ninkovic S,
Sarabia F, Vallberg H, Roschangar F, King NP, Finlay MRV, Giannakakou P,
VerdierPinard P, Hamel E. (1997) Designed epothilones: Combinatorial synthesis,
tubulin assembly properties, and cytotoxic action against taxol-resistant tumor cells.
Angew. Chem.-Int. Edit. 36(19): 2097-103.
338. Nicolaou KC, Winssinger N, Pastor J, DeRoose F. (1997) A general and highly
efficient solid phase synthesis of oligosaccharides. Total synthesis of a heptasaccharide
phytoalexin elicitor (hpe). J. Am. Chem. Soc. 119(2): 449-50.
339. Nicolaou KC, Winssinger N, Pastor J, Ninkovic S, Sarabia F, He Y, Vourloumis D,
Yang Z, Li T, Giannakakou P, Hamel E. (1997) Synthesis of epothilones a and b in solid
and solution phase. Nature. 387(6630): 268-72.
340. Nicolaou KC, Xu JY, Kim S, Ohshima T, Hosokawa S, Pfefferkorn J. (1997)
Synthesis of the tricyclic core of eleutherobin and sarcodictyins and total synthesis of
sarcodictyin a. J. Am. Chem. Soc. 119(46): 11353-4.
341. Nicolaou KC, Yang Z, Ouellette M, Shi GQ, Gartner P, Gunzner JL, Agrios KA,
Huber R, Chadha R, Huang DH. (1997) New synthetic technology for the construction of
9-membered ring cyclic ethers. Construction of the efgh ring skeleton of brevetoxin a. J.
Am. Chem. Soc. 119(34): 8105-6.
342. Parikh SS, Mol CD, Tainer JA. (1997) Base excision repair enzyme family
portrait: Integrating the structure and chemistry of an entire DNA repair pathway.
Structure. 5(12): 1543-50.
343. Pemberton LF, Rosenblum JS, Blobel G. (1997) A distinct and parallel pathway
for the nuclear import of an mrna-binding protein. J. Cell Biol. 139(7): 1645-53.
344. PerkinsBalding D, Dias DP, Glasgow AC. (1997) Location, degree, and direction
of DNA bending associated with the hin recombinational enhancer sequence and fisenhancer
complex. J. Bacteriol. 179(15): 4747-53.
345. Peterson EB, Hilvert D. (1997) Selenosubtilisin's peroxidase activity does not
require an intact oxyanion hole. Tetrahedron. 53(36): 12311-7.
346. Phillips GR, Krushel LA, Crossin KL. (1997) Developmental expression of two rat
sialyltransferases that modify the neural cell adhesion molecule, n-cam. Dev. Brain Res.
102(2): 143-55.
347. Rhind N, Furnari B, Russell P. (1997) Cdc2 tyrosine phosphorylation is required
for the DNA damage checkpoint in fission yeast. Genes Dev. 11(4): 504-11.
348. Rosenblum JS, Pemberton LF, Blobel G. (1997) A nuclear import pathway for a
protein involved in trna maturation. J. Cell Biol. 139(7): 1655-61.
349. Rubin AE, Sharpless KB. (1997) A highly efficient aminohydroxylation process.

Angew. Chem.-Int. Edit. 36(23): 2637-40.
350. Rudolph J, Reddy KL, Chiang JP, Sharpless KB. (1997) Highly efficient
epoxidation of olefins using aqueous h2o2 and catalytic methyltrioxorhenium/pyridine:
Pyridine-mediated ligand acceleration. J. Am. Chem. Soc. 119(26): 6189-90.
351. Safonov IG, Baran PS, Schuster DI. (1997) Synthesis and photophysics of a
novel porphyrin-c-60 hybrid. Tetrahedron Lett. 38(47): 8133-6.
352. Santoro SW, Joyce GF. (1997) A general purpose rna-cleaving DNA enzyme.
Proc. Natl. Acad. Sci. U. S. A. 94(9): 4262-6.
353. Severin K, Lee DH, Kennan AJ, Ghadiri MR. (1997) A synthetic peptide ligase.
Nature. 389(6652): 706-9.
354. Severin K, Lee DH, Martinez JA, Ghadiri MR. (1997) Peptide self-replication via
template-directed ligation. Chem.-Eur. J. 3(7): 1017-24.
355. Sheinerman FB, Brooks CL. (1997) A molecular dynamics simulation study of
segment b1 of protein g. Proteins-Structure Function and Genetics. 29(2): 193-202.
356. Sim MM, Ganesan A. (1997) Solution-phase synthesis of a combinatorial
thiohydantoin library. J. Org. Chem. 62(10): 3230-5.
357. Sim MM, Lee CL, Ganesan A. (1997) Combinatorial synthesis of 2-thioxo-4dihydropyrimidinones.
J. Org. Chem. 62(26): 9358-60.
358. Sosa H, Dias DP, Hoenger A, Whittaker M, WilsonKubalek E, Sablin E, Fletterick
RJ, Vale RD, Milligan RA. (1997) A model for the microtubule-ncd motor protein
complex obtained by cryo-electron microscopy and image analysis. Cell. 90(2): 217-24.
359. Takayama S, Martin R, Wu JY, Laslo K, Siuzdak G, Wong CH. (1997)
Chemoenzymatic preparation of novel cyclic imine sugars and rapid biological activity
evaluation using electrospray mass spectrometry and kinetic analysis. J. Am. Chem.
Soc. 119(35): 8146-51.
360. Takayama S, McGarvey GJ, Wong CH. (1997) Microbial aldolases and
transketolases: New biocatalytic approaches to simple and complex sugars. Annu. Rev.
Microbiol. 51: 285-310.
361. Takayama S, McGarvey GJ, Wong CH. (1997) Enzymes in organic synthesis:
Recent developments in aldol reactions and glycosylations. Chem. Soc. Rev. 26(6):
407-15.
362. Takayama S, Wong CH. (1997) Chemo-enzymatic approach to carbohydrate
recognition. Curr. Org. Chem. 1(2): 109-26.
363. Thomas EA, Cravatt BF, Danielson PE, Gilula NB, Sutcliffe JG. (1997) Fatty acid
amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective
distribution in neurons within the rat central nervous system. J. Neurosci. Res. 50(6):
1047-52.
364. Wang R, Steensma DH, Takaoka Y, Yun JW, Kajimoto T, Wong CH. (1997) A
search for pyrophosphate mimics for the development of substrates and inhibitors of
glycosyltransferases. Bioorg. Med. Chem. 5(4): 661-72.
365. Winston RL, Fitzgerald MC. (1997) Mass spectrometry as a readout of protein
structure and function. Mass Spectrom. Rev. 16(4): 165-79.
366. Witte K, Sears P, Martin R, Wong CH. (1997) Enzymatic glycoprotein synthesis:
Preparation of ribonuclease glycoforms via enzymatic glycopeptide condensation and

glycosylation. J. Am. Chem. Soc. 119(9): 2114-8.
367. Wong CH, MorisVara F, Hung SC, Marron TG, Lin CC, Gong KW, WeitzSchmidt
G. (1997) Small molecules as structural and functional mimics of sialyl lewis x
tetrasaccharide in selectin inhibition: A remarkable enhancement of inhibition by
additional negative charge and/or hydrophobic group. J. Am. Chem. Soc. 119(35):
8152-8.
368. Wu JY, Takayama S, Wong CH, Siuzdak G. (1997) Quantitative electrospray
mass spectrometry for the rapid assay of enzyme inhibitors. Chem. Biol. 4(9): 653-7.
369. Wu L, Russell P. (1997) Nif1, a novel mitotic inhibitor in schizosaccharomyces
pombe. Embo J. 16(6): 1342-50.
370. Wu L, Russell P. (1997) Roles of wee1 and nim1 protein kinases in regulating the
switch from mitotic division to sexual development in schizosaccharomyces pombe. Mol.
Cell. Biol. 17(1): 10-7.
371. Yang YY, Fischer P, Leu SJC, Olee T, Carson DA, Chen PP. (1997) Igg
rheumatoid factors isolated by the surface-displaying phage library technique.
Immunogenetics. 45(5): 301-10.
372. Yang Z, He Y, Vourloumis D, Vallberg H, Nicolaou KC. (1997) Total synthesis of
epothilone a: The olefin metathesis approach. Angew. Chem.-Int. Edit. 36(1-2): 166-8.
373. Yin YH, Chen LL, Beachy R. (1997) Promoter elements required for phloemspecific
gene expression from the rtbv promoter in rice. Plant J. 12(5): 1179-88.
374. Yin YH, Zhu Q, Dai SH, Lamb C, Beachy RN. (1997) Rf2a, a bzip transcriptional
activator of the phloem-specific rice tungro bacilliform virus promoter, functions in
vascular development. Embo J. 16(17): 5247-59.
375. Zhong GF, Hoffmann T, Lerner RA, Danishefsky S, Barbas CF. (1997) Antibodycatalyzed
enantioselective robinson annulation. J. Am. Chem. Soc. 119(34): 8131-2.
376. Zhou ZS, Jiang N, Hilvert D. (1997) An antibody-catalyzed selenoxide
elimination. J. Am. Chem. Soc. 119(15): 3623-4.
377. Albertini M, Pemberton LF, Rosenblum JS, Blobel G. (1998) A novel nuclear
import pathway for the transcription factor tfiis. J. Cell Biol. 143(6): 1447-55.
378. Alexander RW, Nordin BE, Schimmel P. (1998) Activation of microhelix charging
by localized helix destabilization. Proc. Natl. Acad. Sci. U. S. A. 95(21): 12214-9.
379. Allman J, Rosin A, Kumar R, Hasenstaub A. (1998) Parenting and survival in
anthropoid primates: Caretakers live longer. Proc. Natl. Acad. Sci. U. S. A. 95(12):
6866-9.
380. Alper PB, Hendrix M, Sears P, Wong CH. (1998) Probing the specificity of
aminoglycoside ribosomal rna interactions with designed synthetic analogs. J. Am.
Chem. Soc. 120(9): 1965-78.
381. Altschuler Y, Barbas SM, Terlecky LJ, Tang K, Hardy S, Mostov KE, Schmid SL.
(1998) Redundant and distinct functions for dynamin-1 and dynamin-2 isoforms. J. Cell
Biol. 143(7): 1871-81.
382. Aridor M, Weissman J, Bannykh S, Nuoffer C, Balch WE. (1998) Cargo selection
by the copii budding machinery during export from the er. J. Cell Biol. 141(1): 61-70.
383. Boddy MN, Furnari B, Mondesert O, Russell P. (1998) Replication checkpoint
enforced by kinases cds1 and chk1. Science. 280(5365): 909-12.

384. Boger DL, Beresis RT, Loiseleur O, Wu JH, Castle SL. (1998) Synthesis of the
vancomycin cde ring system. Bioorg. Med. Chem. Lett. 8(7): 721-4.
385. Boger DL, Boyce CW, Garbaccio RM, Searcey M. (1998) Synthesis of cc-1065
and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl
chloride. Tetrahedron Lett. 39(16): 2227-30.
386. Boger DL, Ducray P, Chai WY, Jiang WQ, Goldberg J. (1998) Higher order
iminodiacetic acid libraries for probing protein-protein interactions. Bioorg. Med. Chem.
Lett. 8(17): 2339-44.
387. Boger DL, Goldberg J, Jiang WQ, Chai WY, Ducray P, Lee JK, Ozer RS,
Andersson CM. (1998) Higher order iminodiacetic acid libraries for probing proteinprotein
interactions. Bioorg. Med. Chem. 6(8): 1347-78.
388. Boger DL, Henriksen SJ, Cravatt BF. (1998) Oleamide: An endogenous sleepinducing
lipid and prototypical member of a new class of biological signaling molecules.
Curr. Pharm. Design. 4(4): 303-14.
389. Boger DL, Hong JY. (1998) Total synthesis of nothapodytine b and (-)-mappicine.
J. Am. Chem. Soc. 120(6): 1218-22.
390. Boger DL, Kochanny MJ, Cai H, Wyatt D, Kitos PA, Warren MS, Ramcharan J,
Gooljarsingh LT, Benkovic SJ. (1998) Design, synthesis, and evaluation of potential gar
and aicar transformylase inhibitors. Bioorg. Med. Chem. 6(6): 643-59.
391. Boger DL, Miyazaki S, Loiseleur O, Beresis RT, Castle SL, Wu JH, Jin Q. (1998)
Thermal atropisomerism of aglucovancomycin derivatives: Preparation of (m,m,m)- and
(p,m,m)-aglucovancomycins. J. Am. Chem. Soc. 120(35): 8920-6.
392. Boger DL, Patterson JE, Guan XJ, Cravatt BF, Lerner RA, Gilula NB. (1998)
Chemical requirements for inhibition of gap junction communication by the biologically
active lipid oleamide. Proc. Natl. Acad. Sci. U. S. A. 95(9): 4810-5.
393. Boger DL, Patterson JE, Jin Q. (1998) Structural requirements for 5-ht2a and 5ht1a
serotonin receptor potentiation by the biologically active lipid oleamide. Proc. Natl.
Acad. Sci. U. S. A. 95(8): 4102-7.
394. Boger DL, Ramsey TM, Cai H, Hoehn ST, Kozarich JW, Stubbe J. (1998)
Assessment of the role of the bleomycin a(2) pyrimidoblamic acid c4 amino group. J.
Am. Chem. Soc. 120(1): 53-65.
395. Boger DL, Ramsey TM, Cai H, Hoehn ST, Stubbe J. (1998) Definition of the
effect and role of the bleomycin a(2) valerate substituents: Preorganization of a rigid,
compact conformation implicated in sequence-selective DNA cleavage. J. Am. Chem.
Soc. 120(36): 9149-58.
396. Boger DL, Ramsey TM, Cai H, Hoehn ST, Stubbe JA. (1998) A systematic
evaluation of the bleomycin a(2) l-threonine side chain: Its role in preorganization of a
compact conformation implicated in sequence-selective DNA cleavage. J. Am. Chem.
Soc. 120(36): 9139-48.
397. Boger DL, Schaum RP, Garbaccio RM. (1998) Regioselective inverse electron
demand diels-alder reactions of n-acyl 6-amino-3-(methylthio)-1,2,4,5-tetrazines. J. Org.
Chem. 63(18): 6329-37.
398. Bruick RK, Mayfield SP. (1998) Processing of the psba 5 ' untranslated region in
chlamydomonas reinhardtii depends upon factors mediating ribosome association. J.

Cell Biol. 143(5): 1145-53.
399. Cao Y, Musah RA, Wilcox SK, Goodin DB, McRee DE. (1998) Protein conformer
selection by ligand binding observed with crystallography. Protein Sci. 7(1): 72-8.
400. Chung SJ, Takayama S, Wong CH. (1998) Acceptor substrate-based selective
inhibition of galactosyltransferases. Bioorg. Med. Chem. Lett. 8(23): 3359-64.
401. Claiborne CF, Liverton NJ, Nguyen KT. (1998) An efficient synthesis of
tetrasubstituted imidazoles from n-(2-oxo)-amides. Tetrahedron Lett. 39(49): 8939-42.
402. Clark TD, Buehler LK, Ghadiri MR. (1998) Self-assembling cyclic beta(3)-peptide
nanotubes as artificial transmembrane ion channels. J. Am. Chem. Soc. 120(4): 651-6.
403. Clark TD, Buriak JM, Kobayashi K, Isler MP, McRee DE, Ghadiri MR. (1998)
Cylindrical beta-sheet peptide assemblies. J. Am. Chem. Soc. 120(35): 8949-62.
404. Cohen A, Yohn CB, Bruick RK, Mayfield SP. (1998) Translational regulation of
chloroplast gene expression in chlamydomonas reinhardtii. Methods Enzymol. 297: 192-
208.
405. Converso A, Siciliano C, Sindona G. (1998) Synthesis of modified 2',3'dideoxynucleosides
as potential antiviral drugs. Targets in Heterocyclic Systems. 2: 17-
57.
406. Coperet C, Adolfsson H, Chiang JP, Yudin AK, Sharpless KB. (1998) A simple
and efficient method for the preparation of pyridine-n-oxides ii. Tetrahedron Lett. 39(8):
761-4.
407. Crane BR, Arvai AS, Ghosh DK, Wu CQ, Getzoff ED, Stuehr DJ, Tainer JA.
(1998) Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Science. 279(5359): 2121-6.
408. Darlington TK, Wager-Smith K, Ceriani MF, Staknis D, Gekakis N, Steeves TDL,
Weitz CJ, Takahashi JS, Kay SA. (1998) Closing the circadian loop: Clock-induced
transcription of its own inhibitors per and tim. Science. 280(5369): 1599-603.
409. Devanathan S, Genick UK, Canestrelli IL, Meyer TE, Cusanovich MA, Getzoff
ED, Tollin G. (1998) New insights into the photocycle of ectothiorhodospira halophila
photoactive yellow protein: Photorecovery of the long-lived photobleached intermediate
in the met100ala mutant. Biochemistry. 37(33): 11563-8.
410. Egertova M, Giang DK, Cravatt BF, Elphick MR. (1998) A new perspective on
cannabinoid signalling: Complementary localization of fatty acid amide hydrolase and
the cb1 receptor in rat brain. Proc. R. Soc. Lond. Ser. B-Biol. Sci. 265(1410): 2081-5.
411. Gao CS, Lavey BJ, Lo CHL, Datta A, Wentworth P, Janda KD. (1998) Direct
selection for catalysis from combinatorial antibody libraries using a boronic acid probe:
Primary amide bond hydrolysis. J. Am. Chem. Soc. 120(10): 2211-7.
412. Genick UK, Soltis SM, Kuhn P, Canestrelli IL, Getzoff ED. (1998) Structure at
0.85 angstrom resolution of an early protein photocycle intermediate. Nature.
392(6672): 206-9.
413. Giang DG, Cravatt BF. (1998) A second mammalian n-myristoyltransferase. J.
Biol. Chem. 273(12): 6595-8.
414. Gippert GP, Wright PE, Case DA. (1998) Distributed torsion angle grid search in
high dimensions: A systematic approach to nmr structure determination. J. Biomol.
NMR. 11(3): 241-63.

415. Goller ME, Iacovoni JS, Vogt PK, Kruse U. (1998) Glutaredoxin is a direct target
of oncogenic jun. Oncogene. 16(22): 2945-8.
416. Gong XH, Baldo GJ, Kumar NM, Gilula NB, Mathias RT. (1998) Gap junctional
coupling in lenses lacking alpha(3) connexin. Proc. Natl. Acad. Sci. U. S. A. 95(26):
15303-8.
417. Guan Y, Manuel RC, Arvai AS, Parikh SS, Mol CD, Miller JH, Lloyd S, Tainer JA.
(1998) Muty catalytic core, mutant and bound adenine structures define specificity for
DNA repair enzyme superfamily. Nat. Struct. Biol. 5(12): 1058-64.
418. Gypser A, Michel D, Nirschl DS, Sharpless KB. (1998) Dihydroxylation of
polyenes using narasaka's modification of the upjohn procedure. J. Org. Chem. 63(21):
7322-7.
419. Hackeng TM, Dawson PE, Kent SBH, Griffin JH. (1998) Chemical synthesis of
human protein s thrombin-sensitive module and first epidermal growth factor module.
Biopolymers. 46(2): 53-63.
420. Harper JF, Hong BM, Hwang ID, Guo HQ, Stoddard R, Huang JF, Palmgren MG,
Sze H. (1998) A novel calmodulin-regulated ca2+-atpase (aca2) from arabidopsis with
an n-terminal autoinhibitory domain. J. Biol. Chem. 273(2): 1099-106.
421. Hartgerink JD, Clark TD, Ghadiri MR. (1998) Peptide nanotubes and beyond.
Chem.-Eur. J. 4(8): 1367-72.
422. Heine A, Stura EA, Yli-Kauhaluoma JT, Gao CS, Deng QL, Beno BR, Houk KN,
Janda KD, Wilson IA. (1998) An antibody exo diels-alderase inhibitor complex at 1.95
angstrom resolution. Science. 279(5358): 1934-40.
423. Himly M, Foster DN, Bottoli I, Iacovoni JS, Vogt PK. (1998) The df-1 chicken
fibroblast cell line: Transformation induced by diverse oncogenes and cell death
resulting from infection by avian leukosis viruses. Virology. 248(2): 295-304.
424. Hoffmann T, Zhong GF, List B, Shabat D, Anderson J, Gramatikova S, Lerner
RA, Barbas CF. (1998) Aldolase antibodies of remarkable scope. J. Am. Chem. Soc.
120(12): 2768-79.
425. Hogg JH, Ollmann IR, Wetterholm A, Andberg MB, Haeggstrom J, Samuelsson
B, Wong CH. (1998) Probing the activities and mechanisms of leukotriene a(4)
hydrolase with synthetic inhibitors. Chem.-Eur. J. 4(9): 1698-713.
426. Hosfield DJ, Frank G, Weng YH, Tainer JA, Shen B. (1998) Newly discovered
archaebacterial flap endonucleases show a structure-specific mechanism for DNA
substrate binding and catalysis resembling human flap endonuclease-1. J. Biol. Chem.
273(42): 27154-61.
427. Hosfield DJ, Mol CD, Shen BH, Tainer JA. (1998) Structure of the DNA repair
and replication endonuclease and exonuclease fen-1: Coupling DNA and pcna binding
to fen-1 activity. Cell. 95(1): 135-46.
428. Hu TH, Gerace L. (1998) Cdna cloning and analysis of the expression of
nucleoporin p45. Gene. 221(2): 245-53.
429. Inanami O, Johnson JL, McAdara JK, El Benna J, Faust LRP, Newburger PE,
Babior BM. (1998) Activation of the leukocyte nadph oxidase by phorbol ester requires
the phosphorylation of p47(phox) on serine 303 or 304. J. Biol. Chem. 273(16): 9539-
43.

430. Jontes JD, Ostap EM, Pollard TD, Milligan RA. (1998) Three-dimensional
structure of acanthamoeba castellanii myosin-ib (mib) determined by cryoelectron
microscopy of decorated actin filaments. J. Cell Biol. 141(1): 155-62.
431. Kim HS, Hartgerink JD, Ghadiri MR. (1998) Oriented self-assembly of cyclic
peptide nanotubes in lipid membranes. J. Am. Chem. Soc. 120(18): 4417-24.
432. Li J, Nelson MR, Peng CY, Bashford D, Noodleman L. (1998) Incorporating
protein environments in density functional theory: A self-consistent reaction field
calculation of redox potentials of [2fe2s] clusters in ferredoxin and phthalate
dioxygenase reductase. J. Phys. Chem. A. 102(31): 6311-24.
433. Littlefield R, Fowler VM. (1998) Defining actin filament length in striated muscle:
Rulers and caps or dynamic stability? Annu. Rev. Cell Dev. Biol. 14: 487-525.
434. MacBeath G, Kast P. (1998) Uga read-through artifacts - when popular gene
expression systems need a patch. Biotechniques. 24(5): 789-94.
435. MacBeath G, Kast P, Hilvert D. (1998) A small, thermostable, and
monofunctional chorismate mutase from the archeon methanococcus jannaschii.
Biochemistry. 37(28): 10062-73.
436. MacBeath G, Kast P, Hilvert D. (1998) Probing enzyme quaternary structure by
combinatorial mutagenesis and selection. Protein Sci. 7(8): 1757-67.
437. MacBeath G, Kast P, Hilvert D. (1998) Exploring sequence constraints on an
interhelical turn using in vivo selection for catalytic activity. Protein Sci. 7(2): 325-35.
438. MacBeath G, Kast P, Hilvert D. (1998) Redesigning enzyme topology by directed
evolution. Science. 279(5358): 1958-61.
439. Macke TJ, Duncan BS, Goodsell DS, Olson AJ. (1998) Interactive modeling of
supramolecular assemblies. J. Mol. Graph. 16(3): 115-+.
440. Malmendal A, Evenas J, Thulin E, Gippert GP, Drakenberg T, Forsen S. (1998)
When size is important - accommodation of magnesium in a calcium binding regulatory
domain. J. Biol. Chem. 273(44): 28994-9001.
441. Martin R, Witte KL, Wong CH. (1998) The synthesis and enzymatic incorporation
of sialic acid derivatives for use as tools to study the structure, activity, and inhibition of
glycoproteins and other glycoconjugates. Bioorg. Med. Chem. 6(8): 1283-92.
442. Miller M, Baca M, Rao JKM, Kent SBH. (1998) Probing the structural basis of the
catalytic activity of hiv-1 pr through total chemical protein synthesis. Theochem-J. Mol.
Struct. 423(1-2): 137-52.
443. Muranyi A, Finn BE, Gippert GP, Forsen S, Stenflo J, Drakenberg T. (1998)
Solution structure of the n-terminal egf-like domain from human factor vii. Biochemistry.
37(30): 10605-15.
444. Navarro M, Chowen J, Carrera MRA, del Arco I, Villanua MA, Martin Y, Roberts
AJ, Koob GF, de Fonseca FR. (1998) Cb1 cannabinoid receptor antagonist-induced
opiate withdrawal in morphine-dependent rats. Neuroreport. 9(15): 3397-402.
445. Nelson MR, Chazin WJ. (1998) Structures of ef-hand ca2+-binding proteins:
Diversity in the organization, packing and response to ca2+ binding. Biometals. 11(4):
297-318.
446. Nelson MR, Chazin WJ. (1998) An interaction-based analysis of calcium-induced
conformational changes in ca2+ sensor proteins. Protein Sci. 7(2): 270-82.

447. Nicolaou KC, Finlay MRV, Ninkovic S, King NP, He Y, Li TH, Sarabia F,
Vourloumis D. (1998) Synthesis and biological properties of c12,13cyclopropylepothilone
a and related epothilones. Chem. Biol. 5(7): 365-72.
448. Nicolaou KC, He Y, Roschangar F, King NP, Vourloumis D, Li TH. (1998) Total
synthesis of epothilone e and analogues with modified side chains through the stille
coupling reaction. Angew. Chem.-Int. Edit. 37(1-2): 84-7.
449. Nicolaou KC, Jain NF, Natarajan S, Hughes R, Solomon ME, Li H, Ramanjulu
JM, Takayanagi M, Koumbis AE, Bando T. (1998) Total synthesis of vancomycin
aglycon - part 2: Synthesis of amino acids 1-3 and construction of the ab-cod-doe ring
skeleton. Angew. Chem.-Int. Edit. 37(19): 2714-6.
450. Nicolaou KC, Kim SH, Pfefferkorn J, Xu JY, Ohshima T, Hosokawa S,
Vourloumis D, Li TH. (1998) Synthesis and biological activity of sarcodictyins. Angew.
Chem.-Int. Edit. 37(10): 1418-21.
451. Nicolaou KC, Natarajan S, Li H, Jain NF, Hughes R, Solomon ME, Ramanjulu
JM, Boddy CNC, Takayanagi M. (1998) Total synthesis of vancomycin aglycon - part 1:
Synthesis of amino acids 4-7 and construction of the ab-cod ring skeleton. Angew.
Chem.-Int. Edit. 37(19): 2708-14.
452. Nicolaou KC, Ohshima T, Hosokawa S, van Delft FL, Vourloumis D, Xu JY,
Pfefferkorn J, Kim S. (1998) Total synthesis of eleutherobin and eleuthosides a and b. J.
Am. Chem. Soc. 120(34): 8674-80.
453. Nicolaou KC, Pastor J, Barluenga S, Winssinger N. (1998) Polymer-supported
selenium reagents for organic synthesis. Chem. Commun. (18): 1947-8.
454. Nicolaou KC, Pastor J, Winssinger N, Murphy F. (1998) Solid phase synthesis of
macrocycles by an intramolecular ketophosphonate reaction. Synthesis of a (dl)muscone
library. J. Am. Chem. Soc. 120(20): 5132-3.
455. Nicolaou KC, Sarabia F, Ninkovic S, Finlay MRV, Boddy CNC. (1998) Probing
the ring size of epothilones: Total synthesis of [14]-, [15]-, [17]-, and [18]epothilones a.
Angew. Chem.-Int. Edit. 37(1-2): 81-4.
456. Nicolaou KC, Shi GQ, Namoto K, Bernal F. (1998) Synthesis of n-heterocycles
via lactam-derived ketene aminal phosphates. Asymmetric synthesis of cyclic amino
acids. Chem. Commun. (16): 1757-8.
457. Nicolaou KC, Sorensen EJ, Winssinger N. (1998) The art and science of organic
and natural products synthesis. J. Chem. Educ. 75(10): 1225-58.
458. Nicolaou KC, Trujillo JI, Jandeleit B, Chibale K, Rosenfeld M, Diefenbach B,
Cheresh DA, Goodman SL. (1998) Design, synthesis and biological evaluation of
nonpeptide integrin antagonists. Bioorg. Med. Chem. 6(8): 1185-208.
459. Nicolaou KC, Watanabe N, Li J, Pastor J, Winssinger N. (1998) Solid-phase
synthesis of oligosaccharides: Construction of a dodecasaccharide. Angew. Chem.-Int.
Edit. 37(11): 1559-61.
460. Nicolaou KC, Winssinger N, Pastor J, Murphy F. (1998) Solid-phase synthesis of
macrocyclic systems by a cyclorelease strategy: Application of the stille coupling to a
synthesis of (s)-zearalenone. Angew. Chem.-Int. Edit. 37(18): 2534-7.
461. Nicolaou KC, Winssinger N, Vourloumis D, Ohshima T, Kim S, Pfefferkorn J, Xu
JY, Li T. (1998) Solid and solution phase synthesis and biological evaluation of

combinatorial sarcodictyin libraries. J. Am. Chem. Soc. 120(42): 10814-26.
462. Nicolaou KC, Xu JY, Kim S, Pfefferkorn J, Ohshima T, Vourloumis D, Hosokawa
S. (1998) Total synthesis of sarcodictyins a and b. J. Am. Chem. Soc. 120(34): 8661-73.
463. Nicolaou KC, Yang Z, Shi GQ, Gunzner JL, Agrios KA, Gartner P. (1998) Total
synthesis of brevetoxin a. Nature. 392(6673): 264-9.
464. Niculescu AB, Chen XB, Smeets M, Hengst L, Prives C, Reed SI. (1998) Effects
of p21(cip1/waf1) at both the g(1)/s and the g(2)/m cell cycle transitions: Prb is a critical
determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell.
Biol. 18(1): 629-43.
465. Parikh SS, Mol CD, Slupphaug G, Bharati S, Krokan HE, Tainer JA. (1998) Base
excision repair initiation revealed by crystal structures and binding kinetics of human
uracil-DNA glycosylase with DNA. Embo J. 17(17): 5214-26.
466. Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF. (1998) Comparative
characterization of a wild type and transmembrane domain-deleted fatty acid amide
hydrolase: Identification of the transmembrane domain as a site for oligomerization.
Biochemistry. 37(43): 15177-87.
467. Patricelli MP, Patterson JE, Boger DL, Cravatt BF. (1998) An endogenous sleepinducing
compound is a novel competitive inhibitor of fatty acid amide hydrolase. Bioorg.
Med. Chem. Lett. 8(6): 613-8.
468. Pemberton LF, Blobel G, Rosenblum JS. (1998) Transport routes through the
nuclear pore complex. Curr. Opin. Cell Biol. 10(3): 392-9.
469. Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW.
(1998) Inhibiting transthyretin conformational changes that lead to amyloid fibril
formation. Proc. Natl. Acad. Sci. U. S. A. 95(22): 12956-60.
470. Prasad GS, Kresge N, Muhlberg AB, Shaw A, Jung YS, Burgess BK, Stout CD.
(1998) The crystal structure of nadph : Ferredoxin reductase from azotobacter
vinelandii. Protein Sci. 7(12): 2541-9.
471. Rosenblum JS, Pemberton LF, Bonifaci N, Blobel G. (1998) Nuclear import and
the evolution of a multifunctional rna-binding protein. J. Cell Biol. 143(4): 887-99.
472. Santoro SW, Joyce GF. (1998) Mechanism and utility of an rna-cleaving DNA
enzyme. Biochemistry. 37(38): 13330-42.
473. Saphire ACS, Bark SJ, Gerace L. (1998) All four homochiral enantiomers of a
nuclear localization sequence derived from c-myc serve as functional import signals. J.
Biol. Chem. 273(45): 29764-9.
474. Schuster DI, Baran PS, Hatch RK, Khan AU, Wilson SR. (1998) The role of
singlet oxygen in the photochemical formation of c60o. Chem. Commun. (22): 2493-4.
475. Scott CA, Garcia KC, Stura EA, Peterson PA, Wilson IA, Teyton L. (1998)
Engineering protein for x-ray crystallography: The murine major histocompatibility
complex class ii molecule i-a(d). Protein Sci. 7(2): 413-8.
476. Scott CA, Peterson PA, Teyton L, Wilson IA. (1998) Crystal structures of two ia(d)-peptide
complexes reveal that high affinity can be achieved without large anchor
residues. Immunity. 8(3): 319-29.
477. Sears P, Wong CH. (1998) Enzyme action in glycoprotein synthesis. Cell. Mol.
Life Sci. 54(3): 223-52.

478. Sears P, Wong CH. (1998) Mechanism-based inhibition of carbohydratemediated
biological recognitions. Chem. Commun. (11): 1161-70.
479. Severin K, Lee DH, Martinez JA, Vieth M, Ghadiri MR. (1998) Dynamic error
correction in autocatalytic peptide networks. Angew. Chem.-Int. Edit. 37(1-2): 126-8.
480. Sheinerman FB, Brooks CL. (1998) Calculations on folding of segment b1 of
streptococcal protein g. J. Mol. Biol. 278(2): 439-56.
481. Sheinerman FB, Brooks CL. (1998) Molecular picture of folding of a small
alpha/beta protein. Proc. Natl. Acad. Sci. U. S. A. 95(4): 1562-7.
482. Shen BH, Qiu JZ, Hosfield D, Tainer JA. (1998) Flap endonuclease homologs in
archaebacteria exist as independent proteins. Trends Biochem.Sci. 23(5): 171-3.
483. Sim MM, Lee CL, Ganesan A. (1998) Solid-phase combinatorial synthesis of 4hydroxyquinolin-2(1h)-ones.
Tetrahedron Lett. 39(35): 6399-402.
484. Sim MM, Lee CL, Ganesan A. (1998) Solid-phase c-acylation of active methylene
compounds. Tetrahedron Lett. 39(15): 2195-8.
485. Sowdhamini R, Burke DF, Deane C, Huang JF, Mizuguchi K, Nagarajaram HA,
Overington JP, Srinivasan N, Steward RE, Blundell TL. (1998) Protein threedimensional
structural databases: Domains, structurally aligned homologues and
superfamilies. Acta Crystallogr. Sect. D-Biol. Crystallogr. 54: 1168-77.
486. Terkeltaub R, Baird S, Sears P, Santiago R, Boisvert W. (1998) The murine
homolog of the interleukin-8 receptor cxcr-2 is essential for the occurrence of
neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty
synovitis. Arthritis Rheum. 41(5): 900-9.
487. Vieth M, Hirst JD, Brooks CL. (1998) Do active site conformations of small
ligands correspond to low free-energy solution structures? J. Comput.-Aided Mol. Des.
12(6): 563-72.
488. Vieth M, Hirst JD, Dominy BN, Daigler H, Brooks CL. (1998) Assessing search
strategies for flexible docking. J. Comput. Chem. 19(14): 1623-31.
489. Vieth M, Hirst JD, Kolinski A, Brooks CL. (1998) Assessing energy functions for
flexible docking. J. Comput. Chem. 19(14): 1612-22.
490. Wan MH, Cravatt BF, Ring HJZ, Zhang XY, Francke U. (1998) Conserved
chromosomal location and genomic structure of human and mouse fatty-acid amide
hydrolase genes and evaluation of clasper as a candidate neurological mutation.
Genomics. 54(3): 408-14.
491. Wilcox SK, Putnam CD, Sastry M, Blankenship J, Chazin WJ, McRee DE,
Goodin DB. (1998) Rational design of a functional metalloenzyme: Introduction of a site
for manganese binding and oxidation into a heme peroxidase. Biochemistry. 37(48):
16853-62.
492. Wilson-Kubalek EM, Brown RE, Celia H, Milligan RA. (1998) Lipid nanotubes as
substrates for helical crystallization of macromolecules. Proc. Natl. Acad. Sci. U. S. A.
95(14): 8040-5.
493. Winston RL, Fitzgerald MC. (1998) Concentration and desalting of protein
samples for mass spectrometry analysis. Anal. Biochem. 262(1): 83-5.
494. Wischnat R, Martin R, Takayama S, Wong CH. (1998) Chemoenzymatic
synthesis of iminocyclitol derivatives: A useful library strategy for the development of

selective fucosyltransfer enzymes inhibitors. Bioorg. Med. Chem. Lett. 8(23): 3353-8.
495. Witte K, Seitz O, Wong CH. (1998) Solution- and solid-phase synthesis of nprotected
glycopeptide esters of the benzyl type as substrates for subtilisin-catalyzed
glycopeptide couplings. J. Am. Chem. Soc. 120(9): 1979-89.
496. Witte K, Skolnick J, Wong CH. (1998) A synthetic retrotransition (backward
reading) sequence of the right-handed three-helix bundle domain (10-53) of protein a
shows similarity in conformation as predicted by computation. J. Am. Chem. Soc.
120(50): 13042-5.
497. Wittmann V, Takayama S, Gong KW, Weitz-Schmidt G, Wong CH. (1998) Ligand
recognition by e- and p-selectin: Chemoenzymatic synthesis and inhibitory activity of
bivalent sialyl lewis x derivatives and sialyl lewis x carboxylic acids. J. Org. Chem.
63(15): 5137-43.
498. Wong CH, Hendrix M, Manning DD, Rosenbohm C, Greenberg WA. (1998) A
library approach to the discovery of small molecules that recognize rna: Use of a 1,3hydroxyamine
motif as core. J. Am. Chem. Soc. 120(33): 8319-27.
499. Wong CH, Hendrix M, Priestley ES, Greenberg WA. (1998) Specificity of
aminoglycoside antibiotics for the a-site of the decoding region of ribosomal rna. Chem.
Biol. 5(7): 397-406.
500. Yeager M, Wilson-Kubalek EM, Weiner SG, Brown PO, Rein A. (1998)
Supramolecular organization of immature and mature murine leukemia virus revealed by
electron cryo-microscopy: Implications for retroviral assembly mechanisms. Proc. Natl.
Acad. Sci. U. S. A. 95(13): 7299-304.
501. Yohn CB, Cohen A, Danon A, Mayfield SP. (1998) A poly(a) binding protein
functions in the chloroplast as a message-specific translation factor. Proc. Natl. Acad.
Sci. U. S. A. 95(5): 2238-43.
502. Yohn CB, Cohen A, Rosch C, Kuchka MR, Mayfield SP. (1998) Translation of the
chloroplast psba mrna requires the nuclear-encoded poly(a)-binding protein, rb47. J.
Cell Biol. 142(2): 435-42.
503. Zhong GF, Shabat D, List B, Anderson J, Sinha SC, Lerner RA, Barbas CF.
(1998) Catalytic enantioselective retro-aldol reactions: Kinetic resolution of betahydroxyketones
with aldolase antibodies. Angew. Chem.-Int. Edit. 37(18): 2481-4.
504. Adak S, Crooks C, Wang Q, Crane BR, Tainer JA, Getzoff ED, Stuehr DJ. (1999)
Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric
oxide feedback inhibition. J. Biol. Chem. 274(38): 26907-11.
505. Adolfsson H, Converso A, Sharpless KB. (1999) Comparison of amine additives
most effective in the new methyltrioxorhenium-catalyzed epoxidation process.
Tetrahedron Lett. 40(21): 3991-4.
506. Almenar-Queralt A, Lee A, Conley CA, de Pouplana LR, Fowler VM. (1999)
Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin
filament pointed ends in fast skeletal muscle. J. Biol. Chem. 274(40): 28466-75.
507. Alper PB, Meyers C, Lerchner A, Siegel DR, Carreira EM. (1999) Facile, novel
methodology for the synthesis of spiro[pyrrolidin-3,3 '-oxindoles]: Catalyzed ring
expansion reactions of cyclopropanes by aldimines. Angew. Chem.-Int. Edit. 38(21):
3186-9.

508. Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Boyce CW, Boger DL. (1999)
Resolution of a cpzi precursor, synthesis and biological evaluation of (+) and (-)-n-boccpzi:
A further validation of the relationship between chemical solvolytic stability and
cytotoxicity. Bioorg. Med. Chem. Lett. 9(21): 3087-92.
509. Baran PS, Khan AU, Schuster DI, Wilson SR. (1999) Some photophysical
properties of nanotubes. Fullerene Sci. Technol. 7(5): 921-5.
510. Bark SJ, Kent SBH. (1999) Engineering an unnatural n-alpha-anchored disulfide
into bpti by total chemical synthesis: Structural and functional consequences. FEBS
Lett. 460(1): 67-76.
511. Beligere GS, Dawson PE. (1999) Synthesis of a three zinc finger protein, zif268,
by native chemical ligation. Biopolymers. 51(5): 363-9.
512. Beligere GS, Dawson PE. (1999) Conformationally assisted protein ligation using
c-terminal thioester peptides. J. Am. Chem. Soc. 121(26): 6332-3.
513. Bilwes AM, Alex LA, Crane BR, Simon MI. (1999) Structure of chea, a signaltransducing
histidine kinase. Cell. 96(1): 131-41.
514. Boger DL, Boyce CW, Garbaccio RM, Searcey M, Jin Q. (1999) Cbi prodrug
analogs of cc-1065 and the duocarmycins. Synthesis. 1505-9.
515. Boger DL, Boyce CW, Labroli MA, Sehon CA, Jin Q. (1999) Total syntheses of
ningalin a, lamellarin o, lukianol a, and permethyl storniamide a utilizing heterocyclic
azadiene diels-alder reactions. J. Am. Chem. Soc. 121(1): 54-62.
516. Boger DL, Cai H. (1999) Bleomycin: Synthetic and mechanistic studies. Angew.
Chem.-Int. Edit. 38(4): 448-76.
517. Boger DL, Castle SL, Miyazaki S, Wu JH, Beresis RT, Loiseleur O. (1999)
Vancomycin cd and de macrocyclization and atropisomerism studies. J. Org. Chem.
64(1): 70-80.
518. Boger DL, Dong JY, Hikota M, Ishida M. (1999) Total synthesis of phomazarin. J.
Am. Chem. Soc. 121(11): 2471-7.
519. Boger DL, Garbaccio RM. (1999) Shape-dependent catalysis: Insights into the
source of catalysis for the cc-1065 and duocarmycin DNA alkylation reaction. Accounts
Chem. Res. 32(12): 1043-52.
520. Boger DL, Garbaccio RM. (1999) A novel class of cc-1065 and duocarmycin
analogues subject to mitomycin-related reductive activation. J. Org. Chem. 64(22):
8350-62.
521. Boger DL, Garbaccio RM. (1999) Are the duocarmycin and cc-1065 DNA
alkylation reactions acid-catalyzed? Solvolysis ph-rate profiles suggest they are not. J.
Org. Chem. 64(15): 5666-9.
522. Boger DL, Goldberg J, Andersson CM. (1999) Solution phase combinatorial
synthesis of biaryl libraries employing heterogeneous conditions for catalysis and
isolation with size exclusion chromatography for purification. J. Org. Chem. 64(7): 2422-
7.
523. Boger DL, Jiang WQ, Goldberg J. (1999) Convergent solution-phase
combinatorial synthesis with multiplication of diversity through rigid biaryl and
diarylacetylene couplings. J. Org. Chem. 64(19): 7094-100.
524. Boger DL, Miyazaki S, Kim SH, Wu JH, Castle SL, Loiseleur O, Jin Q. (1999)

Total synthesis of the vancomycin aglycon. J. Am. Chem. Soc. 121(43): 10004-11.
525. Boger DL, Miyazaki S, Kim SH, Wu JH, Loiseleur O, Castle SL. (1999)
Diastereoselective total synthesis of the vancomycin aglycon with ordered atropisomer
equilibrations. J. Am. Chem. Soc. 121(13): 3226-7.
526. Boger DL, Sato H, Lerner AE, Austin BJ, Patterson JE, Patricelli MP, Cravatt BF.
(1999) Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: A probe of
structural and conformational features contributing to inhibition. Bioorg. Med. Chem.
Lett. 9(2): 265-70.
527. Bong DT, Steinem C, Janshoff A, Johnson JE, Ghadiri MR. (1999) A highly
membrane-active peptide in flock house virus: Implications for the mechanism of
nodavirus infection. Chem. Biol. 6(7): 473-81.
528. Brondello JM, Boddy MN, Furnari B, Russell P. (1999) Basis for the checkpoint
signal specificity that regulates chk1 and cds1 protein kinases. Mol. Cell. Biol. 19(6):
4262-9.
529. Bruick RK, Mayfield SP. (1999) Light-activated translation of chloroplast mrnas.
Trends Plant Sci. 4(5): 190-5.
530. Brummer O, Gao CS, Mao SL, Weiner DP, Janda KD. (1999) Design, synthesis
and characterization of panning agents for the selection of metalloantibodies. Lett. Pept.
Sci. 6(5-6): 295-302.
531. Burkart MD, Izumi M, Wong CH. (1999) Enzymatic regeneration of 3 'phosphoadenosine-5
'-phosphosulfate using aryl sulfotransferase for the preparative
enzymatic synthesis of sulfated carbohydrates. Angew. Chem.-Int. Edit. 38(18): 2747-
50.
532. Burkart MD, Vincent SP, Wong CH. (1999) An efficient synthesis of cmp-3fluoroneuraminic
acid. Chem. Commun. (16): 1525-6.
533. Burkart MD, Wong CH. (1999) A continuous assay for the spectrophotometric
analysis of sulfotransferases using aryl sulfotransferase iv. Anal. Biochem. 274(1): 131-
7.
534. Carrera MRA, Schulteis G, Koob GF. (1999) Heroin self-administration in
dependent wistar rats: Increased sensitivity to naloxone. Psychopharmacology. 144(2):
111-20.
535. Celia H, Wilson-Kubalek E, Milligan RA, Teyton L. (1999) Structure and function
of a membrane-bound murine mhc class i molecule. Proc. Natl. Acad. Sci. U. S. A.
96(10): 5634-9.
536. Ceriani MF, Darlington TK, Staknis D, Mas P, Petti AA, Weitz CJ, Kay SA. (1999)
Light-dependent sequestration of timeless by cryptochrome. Science. 285(5427): 553-6.
537. Clark TD, Kobayashi K, Ghadiri MR. (1999) Covalent capture and stabilization of
cylindrical beta-sheet peptide assemblies. Chem.-Eur. J. 5(2): 782-92.
538. Colacino E, Converso A, De Nino A, Leggio A, Liguori A, Maiuolo L, Napoli A,
Procopio A, Siciliano C, Sindona G. (1999) Synthesis of isoxazolidino analogues of 2 ',3
'-dideoxynucleosides. Nucleosides Nucleotides. 18(4-5): 581-3.
539. Coombs GS, Rao MS, Olson AJ, Dawson PE, Madison EL. (1999) Revisiting
catalysis by chymotrypsin family serine proteases using peptide substrates and
inhibitors with unnatural main chains. J. Biol. Chem. 274(34): 24074-9.

540. Crane BR, Rosenfeld RJ, Arvai AS, Ghosh DK, Ghosh S, Tainer JA, Stuehr DJ,
Getzoff ED. (1999) N-terminal domain swapping and metal ion binding in nitric oxide
synthase dimerization. Embo J. 18(22): 6271-81.
541. Dmochowski IJ, Crane BR, Wilker JJ, Winkler JR, Gray HB. (1999) Optical
detection of cytochrome p450 by sensitizer-linked substrates. Proc. Natl. Acad. Sci. U.
S. A. 96(23): 12987-90.
542. Dominy BN, Brooks CL. (1999) Development of a generalized born model
parametrization for proteins and nucleic acids. J. Phys. Chem. B. 103(18): 3765-73.
543. Dominy BN, Brooks CL. (1999) Methodology for protein-ligand binding studies:
Application to a model for drug resistance, the hiv/fiv protease system. Proteins-
Structure Function and Genetics. 36(3): 318-31.
544. Evans DA, Johnson DS. (1999) Catalytic enantioselective amination of
enolsilanes using c-2-symmetric copper(ii) complexes as chiral lewis acids. Org. Lett.
1(4): 595-8.
545. Faham S, Day MW, Connick WB, Crane BR, Di Bilio AJ, Schaefer WP, Rees DC,
Gray HB. (1999) Structures of ruthenium-modified pseudomonas aeruginosa azurin and
[ru(2,2 '-bipyridine)(2)(imidazole)(2)]so4 center dot 10h(2)o. Acta Crystallogr. Sect. D-
Biol. Crystallogr. 55: 379-85.
546. Farrow MA, Nordin BE, Schimmel P. (1999) Nucleotide determinants for trnadependent
amino acid discrimination by a class i trna synthetase. Biochemistry. 38(51):
16898-903.
547. Fuller JF, McAdara J, Yaron Y, Sakaguchi M, Fraser JK, Gasson JC. (1999)
Characterization of hox gene expression during myelopoiesis: Role of hox a5 in lineage
commitment and maturation. Blood. 93(10): 3391-400.
548. Furnari B, Blasina A, Boddy MN, McGowan CH, Russell P. (1999) Cdc25
inhibited in vivo and in vitro by checkpoint kinases cds1 and chk1. Mol. Biol. Cell. 10(4):
833-45.
549. Gao CS, Brummer O, Mao SL, Janda KD. (1999) Selection of human
metalloantibodies from a combinatorial phage single-chain antibody library. J. Am.
Chem. Soc. 121(27): 6517-8.
550. Gao CS, Mao SL, Lo CHL, Wirsching P, Lerner RA, Janda KD. (1999) Making
artificial antibodies: A format for phage display of combinatorial heterodimeric arrays.
Proc. Natl. Acad. Sci. U. S. A. 96(11): 6025-30.
551. Ghosh DK, Crane BR, Ghosh S, Wolan D, Gachhui R, Crooks C, Presta A,
Tainer JA, Getzoff ED, Stuehr DJ. (1999) Inducible nitric oxide synthase: Role of the nterminal
beta-hairpin hook and pterin-binding segment in dimerization and
tetrahydrobiopterin interaction. Embo J. 18(22): 6260-70.
552. Ghosh S, Wolan D, Adak S, Crane BR, Kwon NS, Tainer JA, Getzoff ED, Stuehr
DJ. (1999) Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitricoxide
synthase. J. Biol. Chem. 274(34): 24100-12.
553. Giese NA, Marijianowski MMH, McCook O, Hancock A, Ramakrishnan V, Fretto
LJ, Chen CY, Kelly AB, Koziol JA, Wilcox JN, Hanson SR. (1999) The role of alpha and
beta platelet-derived growth factor receptor in the vascular response to injury in
nonhuman primates. Arterioscler. Thromb. Vasc. Biol. 19(4): 900-9.

554. Gong XH, Agopian K, Kumar NM, Gilula NB. (1999) Genetic factors influence
cataract formation in alpha(3) connexin knockout mice. Dev. Genet. 24(1-2): 27-32.
555. Greasley SE, Yamashita MM, Cai H, Benkovic SJ, Boger DL, Wilson IA. (1999)
New insights into inhibitor design from the crystal structure and nmr studies of
escherichia coli gar transformylase in complex with beta-gar and 10-formyl-5,8,10trideazafolic
acid. Biochemistry. 38(51): 16783-93.
556. Greenberg WA, Priestley ES, Sears PS, Alper PB, Rosenbohm C, Hendrix M,
Hung SC, Wong CH. (1999) Design and synthesis of new aminoglycoside antibiotics
containing neamine as an optimal core structure: Correlation of antibiotic activity with in
vitro inhibition of translation. J. Am. Chem. Soc. 121(28): 6527-41.
557. Hackeng TM, Griffin JH, Dawson PE. (1999) Protein synthesis by native chemical
ligation: Expanded scope by using straightforward methodology. Proc. Natl. Acad. Sci.
U. S. A. 96(18): 10068-73.
558. Han S, Craig JA, Putnam CD, Carozzi NB, Tainer JA. (1999) Evolution and
mechanism from structures of an adp-ribosylating toxin and nad complex. Nat. Struct.
Biol. 6(10): 932-6.
559. Hosfield DJ, Guan Y, Haas BJ, Cunningham RP, Tainer JA. (1999) Structure of
the DNA repair enzyme endonuclease iv and its DNA complex: Double-nucleotide
flipping at abasic sites and three-metal-ion catalysis. Cell. 98(3): 397-408.
560. Huang JF, Yang Y, Sepulveda H, Shi WX, Hwang I, Peterson PA, Jackson MR,
Sprent J, Cai ZL. (1999) Tcr-mediated internalization of peptide-mhc complexes
acquired by t cells. Science. 286(5441): 952-4.
561. Iacovoni JS, Russell P, Gaits F. (1999) A new inducible protein expression
system in fission yeast based on the glucose-repressed inv1 promoter. Gene. 232(1):
53-8.
562. Janshoff A, Bong DT, Steinem C, Johnson JE, Ghadiri MR. (1999) An animal
virus-derived peptide switches membrane morphology: Possible relevance to nodaviral
transfection processes. Biochemistry. 38(17): 5328-36.
563. Johnson DS, Hadley T, Mihm MC. (1999) Symmetrical hemorrhagic bullae in an
immunocompromised host. Archives of Dermatology. 135(8): 983-6.
564. Kane RS, Takayama S, Ostuni E, Ingber DE, Whitesides GM. (1999) Patterning
proteins and cells using soft lithography. Biomaterials. 20(23-24): 2363-76.
565. Kanelakis KC, Morishima Y, Dittmar KD, Galigniana MD, Takayama S, Reed JC,
Pratt WB. (1999) Differential effects of the hsp70-binding protein bag-1 on glucocorticoid
receptor folding by the hsp90-based chaperone machinery. J. Biol. Chem. 274(48):
34134-40.
566. Kidd RD, Sears P, Huang DH, Witte K, Wong CH, Farber GK. (1999) Breaking
the low barrier hydrogen bond in a serine protease. Protein Sci. 8(2): 410-7.
567. Koeller KM, Wong CH. (1999) Synthesis of biologically active glycopeptides. J.
Chin. Chem. Soc. 46(5): 659-85.
568. Koepf EK, Petrassi HM, Ratnaswamy G, Huff ME, Sudol M, Kelly JW. (1999)
Characterization of the structure and function of w -> fww domain variants: Identification
of a natively unfolded protein that folds upon ligand binding. Biochemistry. 38(43):
14338-51.

569. Koepf EK, Petrassi HM, Sudol M, Kelly JW. (1999) Ww: An isolated threestranded
antiparallel beta-sheet domain that unfolds and refolds reversibly; evidence for
a structured hydrophobic cluster in urea and gdnhcl and a disordered thermal unfolded
state. Protein Sci. 8(4): 841-53.
570. Lin CC, Moris-Varas F, Weitz-Schmidt G, Wong CH. (1999) Synthesis of sialyl
lewis x mimetics as selectin inhibitors by enzymatic aldol condensation reactions.
Bioorg. Med. Chem. 7(3): 425-33.
571. List B, Shabat D, Zhong GF, Turner JM, Li A, Bui T, Anderson J, Lerner RA,
Barbas CF. (1999) A catalytic enantioselective route to hydroxy-substituted quaternary
carbon centers: Resolution of tertiary aldols with a catalytic antibody. J. Am. Chem. Soc.
121(32): 7283-91.
572. Liu YS, Patricelli MP, Cravatt BF. (1999) Activity-based protein profiling: The
serine hydrolases. Proc. Natl. Acad. Sci. U. S. A. 96(26): 14694-9.
573. Liverton NJ, Butcher JW, Claiborne CF, Claremon DA, Libby BE, Nguyen KT,
Pitzenberger SM, Selnick HG, Smith GR, Tebben A, Vacca JP, Varga SL, Agarwal L,
Dancheck K, Forsyth AJ, Fletcher DS, Frantz B, Hanlon WA, Harper CF, Hofsess SJ,
Kostura M, Lin J, Luell S, O'Neill EA, Orevillo CJ, Pang M, Parsons J, Rolando A, Sahly
Y, Visco DM, O'Keefe SJ. (1999) Design and synthesis of potent, selective, and orally
bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein
kinase. J. Med. Chem. 42(12): 2180-90.
574. Lopez-Girona A, Furnari B, Mondesert O, Russell P. (1999) Nuclear localization
of cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature. 397(6715): 172-5.
575. MacBeath G, Koehler AN, Schreiber SL. (1999) Printing small molecules as
microarrays and detecting protein-ligand interactions en masse. J. Am. Chem. Soc.
121(34): 7967-8.
576. Mao SL, Gao CS, Lo CHL, Wirsching P, Wong CH, Janda KD. (1999) Phagedisplay
library selection of high-affinity human single-chain antibodies to tumorassociated
carbohydrate antigens sialyl lewis(x) and lewis(x). Proc. Natl. Acad. Sci. U.
S. A. 96(12): 6953-8.
577. McAdara J. (1999) Have lab, will travel - the mobile molecular laboratory from mj
research. Scientist. 13(22): 16-.
578. Mohanty D, Dominy BN, Kolinski A, Brooks CL, Skolnick J. (1999) Correlation
between knowledge-based and detailed atomic potentials: Application to the unfolding
of the gcn4 leucine zipper. Proteins-Structure Function and Genetics. 35(4): 447-52.
579. Mol CD, Parikh SS, Putnam CD, Lo TP, Tainer JA. (1999) DNA repair
mechanisms for the recognition and removal of damaged DNA bases. Annu. Rev.
Biophys. Biomol. Struct. 28: 101-28.
580. Nicolaou KC, Baran PS, Jautelat R, He Y, Fong KC, Choi HS, Yoon WH, Zhong
YL. (1999) A novel route to the fused maleic anhydride moiety of cp molecules. Angew.
Chem.-Int. Edit. 38(4): 549-52.
581. Nicolaou KC, Baran PS, Zhong YL, Choi HS, Fong KC, He Y, Yoon WH. (1999)
New synthetic technology for the synthesis of hindered alpha-diazoketones via acyl
mesylates. Org. Lett. 1(6): 883-6.
582. Nicolaou KC, Baran PS, Zhong YL, Choi HS, Yoon WH, He Y, Fong KC. (1999)

Total synthesis of the cp molecules cp-263,114 and cp-225,917 - part 1: Synthesis of
key intermediates and intelligence gathering. Angew. Chem.-Int. Edit. 38(11): 1669-75.
583. Nicolaou KC, Baran PS, Zhong YL, Fong KC, He Y, Yoon WH, Choi HS. (1999)
Total synthesis of the cp molecules cp-225,917 and cp-263,114 - part 2: Evolution of the
final strategy. Angew. Chem.-Int. Edit. 38(11): 1676-8.
584. Nicolaou KC, Boddy CNC, Brase S, Winssinger N. (1999) Chemistry, biology,
and medicine of the glycopeptide antibiotics. Angew. Chem.-Int. Edit. 38(15): 2097-152.
585. Nicolaou KC, Boddy CNC, Li H, Koumbis AE, Hughes R, Natarajan S, Jain NF,
Ramanjulu JM, Brase S, Solomon ME. (1999) Total synthesis of vancomycin - part 2:
Retrosynthetic analysis, synthesis of amino acid building blocks and strategy
evaluations. Chem.-Eur. J. 5(9): 2602-21.
586. Nicolaou KC, Bunnage ME, McGarry DG, Shi SH, Somers PK, Wallace PA, Chu
XJ, Agrios KA, Gunzner JL, Yang Z. (1999) Total synthesis of brevetoxin a: Part 1: First
generation strategy and construction of bcd ring system. Chem.-Eur. J. 5(2): 599-617.
587. Nicolaou KC, Gunzner JL, Shi GQ, Agrios KA, Gartner P, Yang Z. (1999) Total
synthesis of brevetoxin a: Part 4: Final stages and completion. Chem.-Eur. J. 5(2): 646-
58.
588. Nicolaou KC, He Y, Fong KC, Yoon WH, Choi HS, Zhong YL, Baran PS. (1999)
Novel strategies to construct the gamma-hydroxy lactone moiety of the cp molecules.
Synthesis of the cp-225,917 core skeleton. Org. Lett. 1(1): 63-6.
589. Nicolaou KC, Jautelat R, Vassilikogiannakis G, Baran PS, Simonsen KB. (1999)
Studies towards trichodimerol: Novel cascade reactions and polycyclic frameworks.
Chem.-Eur. J. 5(12): 3651-65.
590. Nicolaou KC, King NP, Finlay MRV, He Y, Roschangar F, Vourloumis D, Vallberg
H, Sarabia F, Ninkovic S, Hepworth D. (1999) Total synthesis of epothilone e and
related side-chain modified analogues via a stille coupling based strategy. Bioorg. Med.
Chem. 7(5): 665-97.
591. Nicolaou KC, Koumbis AE, Takayanagi M, Natarajan S, Jain NF, Bando T, Li H,
Hughes R. (1999) Total synthesis of vancomycin - part 3: Synthesis of the aglycon.
Chem.-Eur. J. 5(9): 2622-47.
592. Nicolaou KC, Li H, Boddy CNC, Ramanjulu JM, Yue TY, Natarajan S, Chu XJ,
Brase S, Rubsam F. (1999) Total synthesis of vancomycin - part 1: Design and
development of methodology. Chem.-Eur. J. 5(9): 2584-601.
593. Nicolaou KC, Mitchell HJ, Jain NF, Bando T, Hughes R, Winssinger N, Natarajan
S, Koumbis AE. (1999) Total synthesis of vancomycin - part 4: Attachment of the sugar
moieties and completion of the synthesis. Chem.-Eur. J. 5(9): 2648-67.
594. Nicolaou KC, Mitchell HJ, Jain NF, Winssinger N, Hughes R, Bando T. (1999)
Total synthesis of vancomycin. Angew. Chem.-Int. Edit. 38(1-2): 240-4.
595. Nicolaou KC, Ohshima T, Murphy F, Barluenga S, Xu JY, Winssinger N. (1999)
Synthesis of the macrocyclic core of sanglifehrin a. Chem. Commun. (9): 809-10.
596. Nicolaou KC, Pfefferkorn J, Xu JY, Winssinger N, Ohshima T, Kim SH,
Hosokawa S, Vouruloumis D, van Delft F, Li T. (1999) Total synthesis and chemical
biology of the sarcodictyins. Chem. Pharm. Bull. 47(9): 1199-213.
597. Nicolaou KC, Pfefferkorn JA, Cao GQ, Kim S, Kessabi J. (1999) A facile method

for the solution and solid-phase synthesis of substituted [3.3.1] bicycles. Org. Lett. 1(5):
807-10.
598. Nicolaou KC, Pfefferkorn JA, Kim S, Wei HX. (1999) Synthesis of the fully
functionalized bicyclic core of garsubellin a. J. Am. Chem. Soc. 121(19): 4724-5.
599. Nicolaou KC, Shi GQ, Gunzner JL, Gartner P, Wallace PA, Ouellette MA, Shi SH,
Bunnage ME, Agrios KA, Veale CA, Hwang CK, Hutchinson J, Prasad CVC, Ogilvie
WW, Yang Z. (1999) Total synthesis of brevetoxin a: Part 3: Construction of ghij and
bcde ring systems. Chem.-Eur. J. 5(2): 628-45.
600. Nicolaou KC, Simonsen KB, Vassilikogiannakis G, Baran PS, Vidali VP, Pitsinos
EN, Couladouros EA. (1999) Biomimetic explorations towards the bisorbicillinoids: Total
synthesis of bisorbicillinol, bisorbibutenolide, and trichodimerol. Angew. Chem.-Int. Edit.
38(23): 3555-9.
601. Nicolaou KC, Wallace PA, Shi SH, Ouellette MA, Bunnage ME, Gunzner JL,
Agrios KA, Shi GQ, Gartner P, Yang Z. (1999) Total synthesis of brevetoxin a: Part 2:
Second generation strategy and construction of efgh model system. Chem.-Eur. J. 5(2):
618-27.
602. Nicolaou KC, Xu JY, Murphy F, Barluenga S, Baudoin O, Wei HX, Gray DLF,
Ohshima T. (1999) Total synthesis of sanglifehrin a. Angew. Chem.-Int. Edit. 38(16):
2447-51.
603. Nordin BE, Schimmel P. (1999) Rna determinants for translational editing -
mischarging a minihelix substrate by a trna synthetase. J. Biol. Chem. 274(11): 6835-8.
604. Nuckolls C, Hof F, Martin T, Rebek J. (1999) Chiral microenvironments in selfassembled
capsules. J. Am. Chem. Soc. 121(44): 10281-5.
605. Oza VB, Petrassi HM, Purkey HE, Kelly JW. (1999) Synthesis and evaluation of
anthranilic acid-based transthyretin amyloid fibril inhibitors. Bioorg. Med. Chem. Lett.
9(1): 1-6.
606. Patricelli MP, Cravatt BF. (1999) Fatty acid amide hydrolase competitively
degrades bioactive amides and esters through a nonconventional catalytic mechanism.
Biochemistry. 38(43): 14125-30.
607. Patricelli MP, Lovato MA, Cravatt BF. (1999) Chemical and mutagenic
investigations of fatty acid amide hydrolase: Evidence for a family of serine hydrolases
with distinct catalytic properties. Biochemistry. 38(31): 9804-12.
608. Pemberton LF, Rosenblum JS, Blobel G. (1999) Nuclear import of the tatabinding
protein: Mediation by the karyopherin kap114p and a possible mechanism for
intranuclear targeting. J. Cell Biol. 145(7): 1407-17.
609. Putnam CD, Shroyer MJN, Lundquist AJ, Mol CD, Arvai AS, Mosbaugh DW,
Tainer JA. (1999) Protein mimicry of DNA from crystal structures of the uracil-DNA
glycosylase inhibitor protein and its complex with escherichia coli uracil-DNA
glycosylase. J. Mol. Biol. 287(2): 331-46.
610. Rice S, Lin AW, Safer D, Hart CL, Naber N, Carragher BO, Cain SM,
Pechatnikova E, Wilson-Kubalek EM, Whittaker M, Pate E, Cooke R, Taylor EW,
Milligan RA, Vale RD. (1999) A structural change in the kinesin motor protein that drives
motility. Nature. 402(6763): 778-84.
611. Rosenblum JS, Blobel G. (1999) Autoproteolysis in nucleoporin biogenesis. Proc.

Natl. Acad. Sci. U. S. A. 96(20): 11370-5.
612. Saphire ACS, Bobardt MD, Gallay PA. (1999) Host cyclophilin a mediates hiv-1
attachment to target cells via heparans. Embo J. 18(23): 6771-85.
613. Saunders J, Tarby CM. (1999) Opportunities for novel therapeutic agents acting
at chemokine receptors. Drug Discov. Today. 4(2): 80-92.
614. Schnell JR, Ketchem RR, Boger DL, Chazin WJ. (1999) Binding-induced
activation of DNA alkylation by duocarmycin sa: Insights from the structure of an indole
derivative-DNA adduct. J. Am. Chem. Soc. 121(24): 5645-52.
615. Sears P, Witte K, Wong CH. (1999) The effect of counterion, water concentration,
and stirring on the stability of subtilisin bpn ' in organic solvents. J. Mol. Catal. B-Enzym.
6(3): 297-304.
616. Sears P, Wong CH. (1999) Carbohydrate mimetics: A new strategy for tackling
the problem of carbohydrate-mediated biological recognition. Angew. Chem.-Int. Edit.
38(16): 2301-24.
617. Sever S, Muhlberg AB, Schmid SL. (1999) Impairment of dynamin's gap domain
stimulates receptor-mediated endocytosis. Nature. 398(6727): 481-6.
618. Shen GJ, Datta AK, Izumi M, Koeller KM, Wong CH. (1999) Expression of alpha
2,8/2,9-polysialyltransferase from escherichia coli k92 - characterization of the enzyme
and its reaction products. J. Biol. Chem. 274(49): 35139-46.
619. Shroyer MJN, Bennett SE, Putnam CD, Tainer JA, Mosbaugh DW. (1999)
Mutation of an active site residue in escherichia coli uracil-DNA glycosylase: Effect on
DNA binding, uracil inhibition and catalysis. Biochemistry. 38(15): 4834-45.
620. Sieber F, Wentworth P, Toker JD, Wentworth AD, Metz WA, Reed NN, Janda
KD. (1999) Development and application of a poly(ethylene glycol)-supported
triarylphosphine reagent: Expanding the sphere of liquid-phase organic synthesis. J.
Org. Chem. 64(14): 5188-92.
621. Srinivasan J, Trevathan MW, Beroza P, Case DA. (1999) Application of a
pairwise generalized born model to proteins and nucleic acids: Inclusion of salt effects.
Theor. Chem. Acc. 101(6): 426-34.
622. Takayama S, Chung SJ, Igarashi Y, Ichikawa Y, Sepp A, Lechler RI, Wu JY,
Hayashi T, Siuzdak G, Wong CH. (1999) Selective inhibition of beta-1,4- and alpha-1,3galactosyltransferases:
Donor sugar-nucleotide based approach. Bioorg. Med. Chem.
7(2): 401-9.
623. Takayama S, Lee ST, Hung SC, Wong CH. (1999) Designing enzymatic
resolution of amines. Chem. Commun. (2): 127-8.
624. Takayama S, McDonald JC, Ostuni E, Liang MN, Kenis PJA, Ismagilov RF,
Whitesides GM. (1999) Patterning cells and their environments using multiple laminar
fluid flows in capillary networks. Proc. Natl. Acad. Sci. U. S. A. 96(10): 5545-8.
625. Thomas AA, Sharpless KB. (1999) The catalytic asymmetric aminohydroxylation
of unsaturated phosphonates. J. Org. Chem. 64(22): 8379-85.
626. Thomas EA, Cravatt BF, Sutcliffe JG. (1999) The endogenous lipid oleamide
activates serotonin 5-ht7 neurons in mouse thalamus and hypothalamus. J. Neurochem.
72(6): 2370-8.
627. Tsui V, Garcia C, Cavagnero S, Siuzdak G, Dyson HJ, Wright PE. (1999)

Quench-flow experiments combined with mass spectrometry show apomyoglobin folds
through an obligatory intermediate. Protein Sci. 8(1): 45-9.
628. Vanderwal CD, Vosburg DA, Weiler S, Sorensen EJ. (1999) Postulated
biogenesis of ws9885b and progress toward an enantioselective synthesis. Org. Lett.
1(4): 645-8.
629. Veigel C, Coluccio LM, Jontes JD, Sparrow JC, Milligan RA, Molloy JE. (1999)
The motor protein myosin-i produces its working stroke in two steps. Nature. 398(6727):
530-3.
630. Vincent SP, Burkart MD, Tsai CY, Zhang ZY, Wong CH. (1999) Electrophilic
fluorination-nucleophilic addition reaction mediated by selectfluor: Mechanistic studies
and new applications. J. Org. Chem. 64(14): 5264-79.
631. Vogt PK, Aoki M, Bottoli I, Chang HW, Fu SL, Hecht A, Iacovoni JS, Jiang BH,
Kruse U. (1999) A random walk in oncogene space: The quest for targets. Cell Growth
Differ. 10(12): 777-84.
632. Vollmer MS, Clark TD, Steinem C, Ghadiri MR. (1999) Photoswitchable
hydrogen-bonding in self-organized cylindrical peptide systems. Angew. Chem.-Int. Edit.
38(11): 1598-601.
633. Vosburg DA, Weiler S, Sorensen EJ. (1999) A concise synthesis of fumagillol.
Angew. Chem.-Int. Edit. 38(7): 971-4.
634. Weinstein DS, Nicolaou KC. (1999) Synthesis of the namenamicin a-c
disaccharide: Towards the total synthesis of namenamicin. J. Chem. Soc.-Perkin Trans.
1. (5): 545-57.
635. Wilcox BJ, Ritenour-Rodgers KJ, Asser AS, Baumgart LE, Baumgart MA, Boger
DL, DeBlassio JL, deLong MA, Glufke U, Henz ME, King L, Merkler KA, Patterson JE,
Robleski JJ, Vederas JC, Merkler DJ. (1999) N-acylglycine amidation: Implications for
the biosynthesis of fatty acid primary amides. Biochemistry. 38(11): 3235-45.
636. Winston RL, Millar DP, Gottesfeld JM, Kent SBH. (1999) Characterization of the
DNA binding properties of the bhlh domain of deadpan to single and tandem sites.
Biochemistry. 38(16): 5138-46.
637. Wu WG, Pasternack L, Huang DH, Koeller KM, Lin CC, Seitz O, Wong CH.
(1999) Structural study on o-glycopeptides: Glycosylation-induced conformational
changes of o-glcnac, o-lacnac, o-sialyl-lacnac, and o-sialyl-lewis-x peptides of the mucin
domain of madcam-1. J. Am. Chem. Soc. 121(11): 2409-17.
638. Zhang ZY, Ollmann IR, Ye XS, Wischnat R, Baasov T, Wong CH. (1999)
Programmable one-pot oligosaccharide synthesis. J. Am. Chem. Soc. 121(4): 734-53.
639. Zhong GF, Lerner RA, Barbas CF. (1999) Broadening the aldolase catalytic
antibody repertoire by combining reactive immunization and transition state theory: New
enantio- and diastereoselectivities. Angew. Chem.-Int. Edit. 38(24): 3738-41.
640. Zhou JL, Termin A, Wayland M, Tarby CM. (1999) Solid-phase synthesis of
potential aspartic acid protease inhibitors containing a hydroxyethylamine isostere.
Tetrahedron Lett. 40(14): 2729-32.
641. Zhou ZHS, Flohr A, Hilvert D. (1999) An antibody-catalyzed allylic sulfoxidesulfenate
rearrangement. J. Org. Chem. 64(22): 8334-41.
642. Zhou ZHS, Peariso K, Penner-Hahn JE, Matthews RG. (1999) Identification of

the zinc ligands in cobalamin-independent methionine synthase (mete) from escherichia
coli. Biochemistry. 38(48): 15915-26.
643. Adolfsson H, Coperet C, Chiang JP, Yudin AK. (2000) Efficient epoxidation of
alkenes with aqueous hydrogen peroxide catalyzed by methyltrioxorhenium and 3cyanopyridine.
J. Org. Chem. 65(25): 8651-8.
644. Allan BB, Weissman J, Aridor M, Moyer B, Chen CD, Yoo JS, Balch WE. (2000)
State-specific assays to study biosynthetic cargo selection and role of snares in export
from the endoplasmic reticulum and delivery to the golgi. Methods. 20(4): 411-6.
645. Balicki D, Reisfeld RA, Pertl U, Beutler E, Lode HN. (2000) Histone h2a-mediated
transient cytokine gene delivery induces efficient antitumor responses in murine
neuroblastoma. Proc. Natl. Acad. Sci. U. S. A. 97(21): 11500-4.
646. Bark SJ, Hahn KM. (2000) Fluorescent indicators of peptide cleavage in the
trafficking compartments of living cells: Peptides site-specifically labeled with two dyes.
Methods. 20(4): 429-35.
647. Bark SJ, Schmid S, Hahn KM. (2000) A highly efficient method for site-specific
modification of unprotected peptides after chemical synthesis. J. Am. Chem. Soc.
122(15): 3567-73.
648. Beck ZQ, Hervio L, Dawson PE, Elder JH, Madison EL. (2000) Identification of
efficiently cleaved substrates for hiv-1 protease using a phage display library and use in
inhibitor development. Virology. 274(2): 391-401.
649. Beerheide W, Sim MM, Tan YJ, Bernard HU, Ting AE. (2000) Inactivation of the
human papillomavirus-16 e6 oncoprotein by organic disulfides. Bioorg. Med. Chem.
8(11): 2549-60.
650. Beligere GS, Dawson PE. (2000) Design, synthesis, and characterization of 4ester
ci2, a model for backbone hydrogen bonding in protein alpha-helices. J. Am.
Chem. Soc. 122(49): 12079-82.
651. Boger DL, Aquila BM, Tse WC, Searcey M. (2000) Synthesis and evaluation of a
novel bleomycin a(2) analogue: Continuing assessment of the linker domain.
Tetrahedron Lett. 41(49): 9493-8.
652. Boger DL, Boyce CW. (2000) Selective metal cation activation of a DNA
alkylating agent: Synthesis and evaluation of methyl 1,2,9,9atetrahydrocyclopropa[c]pyrido[3,2-e]indol-4-one-7-carboxylate
(cpyi). J. Org. Chem.
65(13): 4088-100.
653. Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF. (2000)
Fatty acid amide hydrolase substrate specificity. Bioorg. Med. Chem. Lett. 10(23): 2613-
6.
654. Boger DL, Goldberg J, Satoh S, Ambroise Y, Cohen SB, Vogt PK. (2000) Nonamide-based
combinatorial libraries derived from n-boc-iminodiacetic acid: Solutionphase
synthesis of piperazinone libraries with activity against lef-1/beta-cateninmediated
transcription. Helv. Chim. Acta. 83(8): 1825-45.
655. Boger DL, Kim SH, Miyazaki S, Strittmatter H, Weng JH, Mori Y, Rogel O, Castle
SL, McAtee JJ. (2000) Total synthesis of the teicoplanin aglycon. J. Am. Chem. Soc.
122(30): 7416-7.
656. Boger DL, Lee JK, Goldberg J, Jin Q. (2000) Two comparisons of the

performance of positional scanning and deletion synthesis for the identification of active
constituents in mixture combinatorial libraries. J. Org. Chem. 65(5): 1467-74.
657. Boger DL, Santillan A, Searcey M, Brunette SR, Wolkenberg SE, Hedrick MP, Jin
Q. (2000) Synthesis and evaluation of 1,2,8,8a-tetrahydrocyclopropa[c]pyrrolo[3,2e]indol-4(5h)-one,
the parent alkylation subunit of cc-1065 and the duocarmycins:
Impact of the alkylation subunit substituents and its implications for DNA alkylation
catalysis. J. Org. Chem. 65(13): 4101-11.
658. Boger DL, Sato H, Lerner AE, Hedrick MP, Fecik RA, Miyauchi H, Wilkie GD,
Austin BJ, Patricelli MP, Cravatt BF. (2000) Exceptionally potent inhibitors of fatty acid
amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and
anandamide. Proc. Natl. Acad. Sci. U. S. A. 97(10): 5044-9.
659. Boger DL, Searcey M, Tse WC, Jin Q. (2000) Bifunctional alkylating agents
derived from duocarmycin sa: Potent antitumor activity with altered sequence selectivity.
Bioorg. Med. Chem. Lett. 10(5): 495-8.
660. Boger DL, Soenen DR, Boyce CW, Hedrick MP, Jin Q. (2000) Total synthesis of
ningalin b utilizing a heterocyclic azadiene diels-alder reaction and discovery of a new
class of potent multidrug resistant (mdr) reversal agents. J. Org. Chem. 65(8): 2479-83.
661. Boger DL, Weng JH, Miyazaki S, McAtee JJ, Castle SL, Kim SH, Mori Y, Rogel
O, Strittmatter H, Jin Q. (2000) Thermal atropisomerism of teicoplanin aglycon
derivatives: Preparation of the p,p,p and m,p,p atropisomers of the teicoplanin aglycon
via selective equilibration of the de ring system. J. Am. Chem. Soc. 122(41): 10047-55.
662. Boger DL, Wolkenberg SE. (2000) Total synthesis of amaryllidaceae alkaloids
utilizing sequential intramolecular heterocyclic azadiene diels-alder reactions of an
unsymmetrical 1,2,4,5-tetrazine. J. Org. Chem. 65(26): 9120-4.
663. Boger DL, Wolkenberg SE, Boyce CW. (2000) A new method of in situ activation
for a novel class of DNA alkylating agents: Tunable metal cation complexation and
activation. J. Am. Chem. Soc. 122(26): 6325-6.
664. Bong DT, Janshoff A, Steinem C, Ghadiri MR. (2000) Membrane partitioning of
the cleavage peptide in flock house virus. Biophys. J. 78(2): 839-45.
665. Brik A, Keinan E, Dawson PE. (2000) Protein synthesis by solid-phase chemical
ligation using a safety catch linker. J. Org. Chem. 65(12): 3829-35.
666. Brudler R, Meyer TE, Genick UK, Devanathan S, Woo TT, Millar DP, Gerwert K,
Cusanovich MA, Tollin G, Getzoff ED. (2000) Coupling of hydrogen bonding to
chromophore conformation and function in photoactive yellow protein. Biochemistry.
39(44): 13478-86.
667. Bruick RK. (2000) Expression of the gene encoding the proapoptotic nip3 protein
is induced by hypoxia. Proc. Natl. Acad. Sci. U. S. A. 97(16): 9082-7.
668. Burkart MD, Izumi M, Chapman E, Lin CH, Wong CH. (2000) Regeneration of
paps for the enzymatic synthesis of sulfated oligosaccharides. J. Org. Chem. 65(18):
5565-74.
669. Burkart MD, Vincent SP, Duffels A, Murray BW, Ley SV, Wong CH. (2000)
Chemo-enzymatic synthesis of fluorinated sugar nucleotide: Useful mechanistic probes
for glycosyltransferases. Bioorg. Med. Chem. 8(8): 1937-46.
670. Carrera MRA, Ashley JA, Zhou B, Wirsching P, Koob GF, Janda KD. (2000)

Cocaine vaccines: Antibody protection against relapse in a rat model. Proc. Natl. Acad.
Sci. U. S. A. 97(11): 6202-6.
671. Chapman RG, Ostuni E, Takayama S, Holmlin RE, Yan L, Whitesides GM.
(2000) Surveying for surfaces that resist the adsorption of proteins. J. Am. Chem. Soc.
122(34): 8303-4.
672. Chappell SA, Johnson SM, Shaw JA, Walker RA. (2000) Expression of oestrogen
receptor alpha variants in non-malignant breast and early invasive breast carcinomas. J.
Pathol. 192(2): 159-65.
673. Chen HW, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD. (2000)
Deoxysugars in glycopeptide antibiotics: Enzymatic synthesis of tdp-l-epivancosamine
in chloroeremomycin biosynthesis. Proc. Natl. Acad. Sci. U. S. A. 97(22): 11942-7.
674. Clark D. (2000) Synthesis of (-)-brevioxime. Tetrahedron. 56(34): 6181-4.
675. Cooperman BS, Alexander RW, Bukhtiyarov Y, Vladimirov SN, Druzina Z, Wang
R, Zuno N. (2000) Photolabile derivatives of oligonucleotides as probes of ribosomal
structure. Methods Enzymol. 318: 118-36.
676. Corper AL, Stratmann T, Apostolopoulos V, Scott CA, Garcia KC, Kang AS,
Wilson IA, Teyton L. (2000) A structural framework for deciphering the link between ia(g7)
and autoimmune diabetes. Science. 288(5465): 505-11.
677. Crane BR, Arvai AS, Ghosh S, Getzoff ED, Stuehr DJ, Tainer JA. (2000)
Structures of the n-omega-hydroxy-l-arginine complex of inducible nitric oxide synthase
oxygenase dimer with active and inactive pterins. Biochemistry. 39(16): 4608-21.
678. Cravatt BF, Sorensen EJ. (2000) Chemical strategies for the global analysis of
protein function. Curr. Opin. Chem. Biol. 4(6): 663-8.
679. Dai XC, Joyce GF. (2000) In vitro evolution of a ribozyme that contains 5bromouridine.
Helv. Chim. Acta. 83(8): 1701-10.
680. Daniels DS, Mol CD, Arvai AS, Kanugula S, Pegg AE, Tainer JA. (2000) Active
and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base
binding. Embo J. 19(7): 1719-30.
681. Daniels DS, Tainer JA. (2000) Conserved structural motifs governing the
stoichiometric repair of alkylated DNA by o-6-alkylguanine-DNA alkyltransferase.
Mutation Research-DNA Repair. 460(3-4): 151-63.
682. Darlington TK, Lyons LC, Hardin PE, Kay SA. (2000) The period e-box is
sufficient to drive circadian oscillation of transcription in vivo. J. Biol. Rhythms. 15(6):
462-71.
683. Dawson PE, Kent SBH. (2000) Synthesis of native proteins by chemical ligation.
Annu. Rev. Biochem. 69: 923-60.
684. Demchuk E, Genick UK, Woo TT, Getzoff ED, Bashford D. (2000) Protonation
states and ph titration in the photocycle of photoactive yellow protein. Biochemistry.
39(5): 1100-13.
685. Demko ZP, Bartsch M, Sharpless KB. (2000) Primary amides. A general nitrogen
source for catalytic asymmetric aminohydroxylation of olefins. Org. Lett. 2(15): 2221-3.
686. Deniz AA, Laurence TA, Beligere GS, Dahan M, Martin AB, Chemla DS, Dawson
PE, Schultz PG, Weiss S. (2000) Single-molecule protein folding: Diffusion fluorescence
resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2. Proc.

Natl. Acad. Sci. U. S. A. 97(10): 5179-84.
687. Egertova M, Cravatt BF, Elphick MR. (2000) Fatty acid amide hydrolase
expression in rat choroid plexus: Possible role in regulation of the sleep-inducing action
of oleamide. Neurosci. Lett. 282(1-2): 13-6.
688. Fischer RS, Lee A, Fowler VM. (2000) Tropomodulin and tropomyosin mediate
lens cell actin cytoskeleton reorganization in vitro. Invest. Ophthalmol. Vis. Sci. 41(1):
166-74.
689. Garbaccio RM, Danishefsky SJ. (2000) Efficient asymmetric synthesis of radicicol
dimethyl ether: A novel application of ring-forming olefin metathesis. Org. Lett. 2(20):
3127-9.
690. Gascoigne NRJ, Alam SM, Lin CM, McGuire MV, Marine S, Niederberger N,
Redpath S, Sim BC, Travers PJ, Yachi P, Zal MA, Zal T. (2000) T cell receptor binding
kinetics and special role of v alpha in t cell development and activation. Immunol. Res.
21(2-3): 225-31.
691. Genick UK, Chory J. (2000) Red light sensing in plants. Curr. Biol. 10(18): R651-
R4.
692. Gottesfeld JM, Turner JM, Dervan PB. (2000) Chemical approaches to control
gene expression. Gene Expr. 9(1-2): 77-91.
693. Guy RK. (2000) Inhibition of sonic hedgehog autoprocessing in cultured
mammalian cells by sterol deprivation. Proc. Natl. Acad. Sci. U. S. A. 97(13): 7307-12.
694. Hackeng TM, Fernandez JA, Dawson PE, Kent SBH, Griffin JH. (2000) Chemical
synthesis and spontaneous folding of a multidomain protein: Anticoagulant microprotein
s. Proc. Natl. Acad. Sci. U. S. A. 97(26): 14074-8.
695. Hanson MA, Oost TK, Sukonpan C, Rich DH, Stevens RC. (2000) Structural
basis for babim inhibition of botulinum neurotoxin type b protease. J. Am. Chem. Soc.
122(45): 11268-9.
696. Hanson MA, Stevens RC. (2000) Cocrystal structure of synaptobrevin-ii bound to
botulinum neurotoxin type b at 2.0 angstrom resolution. Nat. Struct. Biol. 7(8): 687-92.
697. Hazan RB, Phillips GR, Qiao RF, Norton L, Aaronson SA. (2000) Exogenous
expression of n-cadherin in breast cancer cells induces cell migration, invasion, and
metastasis. J. Cell Biol. 148(4): 779-90.
698. Hof F, Nuckolls C, Craig SL, Martin T, Rebek J. (2000) Emergent conformational
preferences of a self-assembling small molecule: Structure and dynamics in a tetrameric
capsule. J. Am. Chem. Soc. 122(44): 10991-6.
699. Hof F, Nuckolls C, Rebek J. (2000) Diversity and selection in self-assembled
tetrameric capsules. J. Am. Chem. Soc. 122(17): 4251-2.
700. Hornstein EP, O'Carroll DC, Anderson JC, Laughlin SB. (2000) Sexual
dimorphism matches photoreceptor performance to behavioural requirements. Proc. R.
Soc. Lond. Ser. B-Biol. Sci. 267(1457): 2111-7.
701. Hotta K, Kikuchi K, Hilvert D. (2000) Catalysis of 3-carboxy-1,2-benzisoxazole
decarboxylation by hydrophobic antibody binding pockets. Helv. Chim. Acta. 83(9):
2183-91.
702. Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson LA. (2000) Catalysis of
decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures

of abzyme 21d8. J. Mol. Biol. 302(5): 1213-25.
703. Hwang I, Huang JF, Kishimoto H, Brunmark A, Peterson PA, Jackson MR, Surh
CD, Cai ZL, Sprent J. (2000) T cells can use either t cell receptor or cd28 receptors to
absorb and internalize cell surface molecules derived from antigen-presenting cells. J.
Exp. Med. 191(7): 1137-48.
704. Jontes JD, Buchanan J, Smith SJ. (2000) Growth cone and dendrite dynamics in
zebrafish embryos: Early events in synaptogenesis imaged in vivo. Nat. Neurosci. 3(3):
231-7.
705. Jontes JD, Smith SJ. (2000) Filopodia, spines, and the generation of synaptic
diversity. Neuron. 27(1): 11-4.
706. Kanelakis KC, Murphy PJM, Galigniana MD, Morishima Y, Takayama S, Reed
JC, Toft DO, Pratt WB. (2000) Hsp70 interacting protein hip does not affect
glucocorticoid receptor folding by the hsp90-based chaperone machinery except to
oppose the effect of bag-1. Biochemistry. 39(46): 14314-21.
707. Karlstrom A, Zhong GF, Rader C, Larsen NA, Heine A, Fuller R, List B, Tanaka
F, Wilson IA, Barbas CF, Lerner RA. (2000) Using antibody catalysis to study the
outcome of multiple evolutionary trials of a chemical task. Proc. Natl. Acad. Sci. U. S. A.
97(8): 3878-83.
708. Kenis PJA, Ismagilov RF, Takayama S, Whitesides GM, Li SL, White HS. (2000)
Fabrication inside microchannels using fluid flow. Accounts Chem. Res. 33(12): 841-7.
709. King CC, Zenke FT, Dawson PE, Dutil EM, Newton AC, Hemmings BA, Bokoch
GM. (2000) Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.
J. Biol. Chem. 275(24): 18108-13.
710. Klabunde T, Petrassi HM, Oza VB, Raman P, Kelly JW, Sacchettini JC. (2000)
Rational design of potent human transthyretin amyloid disease inhibitors. Nat. Struct.
Biol. 7(4): 312-21.
711. Koeller KM, Smith MEB, Huang RF, Wong CH. (2000) Chemoenzymatic
synthesis of a psgl-1 n-terminal glycopeptide containing tyrosine sulfate and alpha-olinked
sialyl lewis x. J. Am. Chem. Soc. 122(17): 4241-2.
712. Koeller KM, Smith MEB, Wong CH. (2000) Chemoenzymatic synthesis of psgl-1
glycopeptides: Sulfation on tyrosine affects glycosyltransferase-catalyzed synthesis of
the o-glycan. Bioorg. Med. Chem. 8(5): 1017-25.
713. Koeller KM, Smith MEB, Wong CH. (2000) Tyrosine sulfation on a psgl-1
glycopeptide influences the reactivity of glycosyltransferases responsible for synthesis
of the attached o-glycan. J. Am. Chem. Soc. 122(4): 742-3.
714. Koeller KM, Wong CH. (2000) Synthesis of complex carbohydrates and
glycoconjugates: Enzyme-based and programmable one-pot strategies. Chem. Rev.
100(12): 4465-93.
715. Koeller KM, Wong CH. (2000) Chemoenzymatic synthesis of sialyl-trimeric-lewis
x. Chem.-Eur. J. 6(7): 1243-51.
716. Koeller KM, Wong CH. (2000) Complex carbohydrate synthesis tools for
glycobiologists: Enzyme-based approach and programmable one-pot strategies.
Glycobiology. 10(11): 1157-69.
717. Koeller KM, Wong CH. (2000) Emerging themes in medicinal glycoscience. Nat.

Biotechnol. 18(8): 835-41.
718. Kresge N, Vacquier VD, Stout CD. (2000) 1.35 and 2.07 angstrom resolution
structures of the red abalone sperm lysin monomer and dimer reveal features involved
in receptor binding. Acta Crystallogr. Sect. D-Biol. Crystallogr. 56: 34-41.
719. Kresge N, Vacquier VD, Stout CD. (2000) The high resolution crystal structure of
green abalone sperm lysin: Implications for species-specific binding of the egg receptor.
J. Mol. Biol. 296(5): 1225-34.
720. Kustedjo K, Bracey MH, Cravatt BF. (2000) Torsin a and its torsion dystoniaassociated
mutant forms are lumenal glycoproteins that exhibit distinct subcellular
localizations. J. Biol. Chem. 275(36): 27933-9.
721. Lee A, Fischer RS, Fowler VM. (2000) Stabilization and remodeling of the
membrane skeleton during lens fiber cell differentiation and maturation. Dev. Dyn.
217(3): 257-70.
722. Lee CL, Sim MM. (2000) Solid-phase combinatorial synthesis of 5-arylalkylidene
rhodanine. Tetrahedron Lett. 41(30): 5729-32.
723. Leveque VJP, Stroupe ME, Lepock JR, Cabelli DE, Tainer JA, Nick HS,
Silverman DN. (2000) Multiple replacements of glutamine 143 in human manganese
superoxide dismutase: Effects on structure, stability, and catalysis. Biochemistry.
39(24): 7131-7.
724. Lin YC, Beck Z, Lee T, Le VD, Morris GM, Olson AJ, Wong CH, Elder JH. (2000)
Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease.
J. Virol. 74(10): 4710-20.
725. Lu YH, Wassmann R, Neue HU, Huang CY. (2000) Atmospheric pollutants and
trace gasses - dissolved organic carbon and methane emissions from a rice paddy
fertilized with ammonium and nitrate. J. Environ. Qual. 29(6): 1733-40.
726. Lu YH, Wassmann R, Neue HU, Huang CY. (2000) Dynamics of dissolved
organic carbon and methane emissions in a flooded rice soil. Soil Sci. Soc. Am. J. 64(6):
2011-7.
727. Lyons LC, Darlington TK, Hao HP, Houl J, Kay SA, Hardin PE. (2000) Specific
sequences outside the e-box are required for proper per expression and behavioral
rescue. J. Biol. Rhythms. 15(6): 472-82.
728. MacBeath G, Schreiber SL. (2000) Printing proteins as microarrays for highthroughput
function determination. Science. 289(5485): 1760-3.
729. Marx PF, Hackeng TM, Dawson PE, Griffin JH, Meijers JCM, Bouma BN. (2000)
Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process
that involves conformational instability rather than proteolytic cleavage. J. Biol. Chem.
275(17): 12410-5.
730. Mas P, Devlin PF, Panda S, Kay SA. (2000) Functional interaction of
phytochrome b and cryptochrome 2. Nature. 408(6809): 207-11.
731. McAdara J. (2000) Wired. Scientist. 14(13): 20-.
732. McAdara J. (2000) Inner sanctum. Scientist. 14(11): 23-5.
733. McAdara J. (2000) Nuclear receptors on the web. Scientist. 14(11): 25-.
734. McAdara J. (2000) A step ahead - clontech's advantage (r) one-step rt-pcr kit
simplifies mrna detection. Scientist. 14(7): 30-.

735. McAdara J. (2000) The resolution solution. Scientist. 14(3): 24-6.
736. McKisic MD, Redmond WL, Barthold SW. (2000) T cell-mediated pathology in
murine lyme borreliosis. J. Immunol. 164(12): 6096-9.
737. Merlic CA, Aldrich CC, Albaneze-Walker J, Saghatelian A. (2000) Carbene
complexes in the synthesis of complex natural products: Total synthesis of the
calphostins. J. Am. Chem. Soc. 122(13): 3224-5.
738. Mol CD, Hosfield DJ, Tainer JA. (2000) Abasic site recognition by two
apurinic/apyrimidinic endonuclease families in DNA base excision repair: The 3 ' ends
justify the means. Mutation Research-DNA Repair. 460(3-4): 211-29.
739. Muhlberg AB, Schmid SL. (2000) Domain structure and function of dynamin
probed by limited proteolysis. Methods. 20(4): 475-83.
740. Mundorff EC, Hanson MA, Varvak A, Ulrich H, Schulz PG, Stevens RC. (2000)
Conformational effects in biological catalysis: An antibody-catalyzed oxy-cope
rearrangement. Biochemistry. 39(4): 627-32.
741. Nicholson SE, De Souza D, Fabri LJ, Corbin J, Willson TA, Zhang JG, Silva A,
Asimakis M, Farley A, Nash AD, Metcalf D, Hilton DJ, Nicola NA, Baca M. (2000)
Suppressor of cytokine signaling-3 preferentially binds to the shp-2-binding site on the
shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. U. S. A. 97(12): 6493-8.
742. Nicolaou KC, Baran PS, Zhong YL. (2000) Novel solution- and solid-phase
chemistry of alpha-sulfonated ketones applicable to combinatorial chemistry. J. Am.
Chem. Soc. 122(41): 10246-8.
743. Nicolaou KC, Baran PS, Zhong YL, Vega JA. (2000) Novel ibx-mediated
processes for the synthesis of amino sugars and libraries thereof. Angew. Chem.-Int.
Edit. 39(14): 2525-+.
744. Nicolaou KC, Cao GQ, Pfefferkorn JA. (2000) Selenium-based solid-phase
synthesis of benzopyrans ii: Applications to combinatorial synthesis of medicinally
relevant small organic molecules. Angew. Chem.-Int. Edit. 39(4): 739-43.
745. Nicolaou KC, Fylaktakidou KC, Mitchell HJ, van Delft FL, Rodriguez RM, Conley
SR, Jin ZD. (2000) Total synthesis of everninomicin 13,384-1 - part 4: Explorations of
methodology; stereocontrolled synthesis of 1,1 '-disaccharides, 1,2-seleno migrations in
carbohydrates, and solution- and solid-phase synthesis of 2-deoxy glycosides and
orthoesters. Chem.-Eur. J. 6(17): 3166-85.
746. Nicolaou KC, Hepworth D, King NP, Finlay MRV, Scarpelli R, Pereira MMA,
Bollbuck B, Bigot A, Werschkun B, Winssinger N. (2000) Total synthesis of 16desmethylepothilone
b, epothilone b-10 epothilone f, and related side chain modified
epothilone b analogues. Chem.-Eur. J. 6(15): 2783-800.
747. Nicolaou KC, Hughes R, Cho SY, Winssinger N, Smethurst C, Labischinski H,
Endermann R. (2000) Target-accelerated combinatorial synthesis and discovery of
highly potent antibiotics effective against vancomycin-resistant bacteria. Angew. Chem.-
Int. Edit. 39(21): 3823-+.
748. Nicolaou KC, Jung JK, Yoon WH, He Y, Zhong YL, Baran PS. (2000) The
absolute configuration and asymmetric total synthesis of the cp molecules (cp-263,114
and cp-225,917, phomoidrides b and a). Angew. Chem.-Int. Edit. 39(10): 1829-+.
749. Nicolaou KC, Koumbis AE, Snyder SA, Simonsen KB. (2000) Novel reactions

initiated by titanocene methylidenes: Deoxygenation of sulfoxides, n-oxides, and
selenoxides. Angew. Chem.-Int. Edit. 39(14): 2529-+.
750. Nicolaou KC, Li YW, Weyershausen B, Wei HX. (2000) Synthesis of the
macrocyclic core of apoptolidin. Chem. Commun. (4): 307-8.
751. Nicolaou KC, Mitchell HJ, Rodriguez RM, Fylaktakidou KC, Suzuki H, Conley SR.
(2000) Total synthesis of everninomicin 13,384-1 - part 3: Synthesis of the de fragment
and completion of the total synthesis. Chem.-Eur. J. 6(17): 3149-65.
752. Nicolaou KC, Murphy F, Barluenga S, Ohshima T, Wei H, Xu J, Gray DLF,
Baudoin O. (2000) Total synthesis of the novel immunosuppressant sanglifehrin a. J.
Am. Chem. Soc. 122(16): 3830-8.
753. Nicolaou KC, Pfefferkorn JA, Barluenga S, Mitchell HJ, Roecker AJ, Cao GQ.
(2000) Natural product-like combinatorial libraries based on privileged structures. 3. The
"Libraries from libraries" Principle for diversity enhancement of benzopyran libraries. J.
Am. Chem. Soc. 122(41): 9968-76.
754. Nicolaou KC, Pfefferkorn JA, Cao GQ. (2000) Selenium-based solid-phase
synthesis of benzopyrans i: Applications to combinatorial synthesis of natural products.
Angew. Chem.-Int. Edit. 39(4): 734-9.
755. Nicolaou KC, Pfefferkorn JA, Mitchell HJ, Roecker AJ, Barluenga S, Cao GQ,
Affleck RL, Lillig JE. (2000) Natural product-like combinatorial libraries based on
privileged structures. 2. Construction of a 10 000-membered benzopyran library by
directed split-and-pool chemistry using nanokans and optical encoding. J. Am. Chem.
Soc. 122(41): 9954-67.
756. Nicolaou KC, Pfefferkorn JA, Roecker AJ, Cao GQ, Barluenga S, Mitchell HJ.
(2000) Natural product-like combinatorial libraries based on privileged structures. 1.
General principles and solid-phase synthesis of benzopyrans. J. Am. Chem. Soc.
122(41): 9939-53.
757. Nicolaou KC, Pfefferkorn JA, Schuler F, Roecker AJ, Cao GQ, Casida JE. (2000)
Combinatorial synthesis of novel and potent inhibitors of nadh : Ubiquinone
oxidoreductase. Chem. Biol. 7(12): 979-92.
758. Nicolaou KC, Roecker AJ, Pfefferkorn JA, Cao GQ. (2000) A novel strategy for
the solid-phase synthesis of substituted indolines. J. Am. Chem. Soc. 122(12): 2966-7.
759. Nicolaou KC, Snyder SA, Bigot A, Pfefferkorn JA. (2000) Solution and solidphase
synthesis of functionalized 3-arylbenzofurans by a novel cyclofragmentationrelease
pathway. Angew. Chem.-Int. Edit. 39(6): 1093-+.
760. Nicolaou KC, Snyder SA, Simonsen KB, Koumbis AE. (2000) Model studies
towards diazonamide a: Synthesis of the heterocyclic core. Angew. Chem.-Int. Edit.
39(19): 3473-+.
761. Nicolaou KC, Vassilikogiannakis G, Kranich R, Baran PS, Zhong YL, Natarajan
S. (2000) New synthetic technology for the mild and selective one-carbon homologation
of hindered aldehydes in the presence of ketones. Org. Lett. 2(13): 1895-8.
762. Nicolaou KC, Vassilikogiannakis G, Simonsen KB, Baran PS, Zhong YL, Vidali
VP, Pitsinos EN, Couladouros EA. (2000) Biomimetic total synthesis of bisorbicillinol,
bisorbibutenolide, trichodimerol, and designed analogues of the bisorbicillinoids. J. Am.
Chem. Soc. 122(13): 3071-9.

763. Nicolaou KC, Vourloumis D, Winssinger N, Baran PS. (2000) The art and science
of total synthesis at the dawn of the twenty-first century. Angew. Chem.-Int. Edit. 39(1):
44-122.
764. Nicolaou KC, Winssinger N, Hughes R, Smethurst C, Cho SY. (2000) New
selenium-based safety-catch linkers: Solid-phase semisynthesis of vancomycin. Angew.
Chem.-Int. Edit. 39(6): 1084-+.
765. Nicolaou KC, Zhong YL, Baran PS. (2000) New synthetic technology for the rapid
construction of novel heterocycles - part 1: The reaction of dess-martin periodinane with
anilides and related compounds. Angew. Chem.-Int. Edit. 39(3): 622-+.
766. Nicolaou KC, Zhong YL, Baran PS. (2000) New synthetic technology for the rapid
construction of novel heterocycles - part 2. The reaction of ibx with anilides and related
compounds. Angew. Chem.-Int. Edit. 39(3): 625-+.
767. Nicolaou KC, Zhong YL, Baran PS. (2000) A new method for the one-step
synthesis of alpha,beta-unsaturated carbonyl systems from saturated alcohols and
carbonyl compounds. J. Am. Chem. Soc. 122(31): 7596-7.
768. Niculescu AB, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. (2000)
Identifying a series of candidate genes for mania and psychosis: A convergent
functional genomics approach. Physiol. Genomics. 4(1): 83-91.
769. Offer J, Dawson PE. (2000) N-alpha-2-mercaptobenzylamine-assisted chemical
ligation. Org. Lett. 2(1): 23-6.
770. Ogawa AK, Abou-Zied OK, Tsui V, Jimenez R, Case DA, Romesberg FE. (2000)
A phototautomerizable model DNA base pair. J. Am. Chem. Soc. 122(41): 9917-20.
771. Ozer RS, Halpain S. (2000) Phosphorylation-dependent localization of
microtubule-associated protein map2c to the actin cytoskeleton. Mol. Biol. Cell. 11(10):
3573-87.
772. Parikh SS, Putnam CD, Tainer JA. (2000) Lessons learned from structural results
on uracil-DNA glycosylase. Mutation Research-DNA Repair. 460(3-4): 183-99.
773. Parikh SS, Walcher G, Jones GD, Slupphaug G, Krokan HE, Blackburn GM,
Tainer JA. (2000) Uracil-DNA glycosylase-DNA substrate and product structures:
Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proc. Natl. Acad. Sci. U. S. A. 97(10): 5083-8.
774. Patricelli MP, Cravatt BF. (2000) Clarifying the catalytic roles of conserved
residues in the amidase signature family. J. Biol. Chem. 275(25): 19177-84.
775. Pelletier AJ, van der Laan LJW, Hildbrand P, Siani MA, Thompson DA, Dawson
PE, Torbett BE, Salomon DR. (2000) Presentation of chemokine sdf-1 alpha by
fibronectin mediates directed migration of t cells. Blood. 96(8): 2682-90.
776. Petersen TN, Lundegaard C, Nielsen M, Bohr H, Bohr J, Brunak S, Gippert GP,
Lund O. (2000) Prediction of protein secondary structure at 80% accuracy. Proteins-
Structure Function and Genetics. 41(1): 17-20.
777. Petrassi HM, Klabunde T, Sacchettini J, Kelly JW. (2000) Structure-based design
of n-phenyl phenoxazine transthyretin amyloid fibril inhibitors. J. Am. Chem. Soc.
122(10): 2178-92.
778. Putnam CD, Arvai AS, Bourne Y, Tainer JA. (2000) Active and inhibited human
catalase structures: Ligand and nadph binding and catalytic mechanism. J. Mol. Biol.

296(1): 295-309.
779. Putnam CD, Tainer JA. (2000) The food of sweet and bitter fancy. Nat. Struct.
Biol. 7(1): 17-8.
780. Rouiller I, Butel VM, Latterich M, Milligan RA, Wilson-Kubalek EM. (2000) A
major conformational change in p97 aaa atpase upon atp binding. Mol. Cell. 6(6): 1485-
90.
781. Sanghvi YS, Guo ZQ, Pfundheller HM, Converso A. (2000) Improved process for
the preparation of nucleosidic phosphoramidites using a safer and cheaper activator.
Organic Process Research & Development. 4(3): 175-81.
782. Santoro SW, Joyce GF, Sakthivel K, Gramatikova S, Barbas CF. (2000) Rna
cleavage by a DNA enzyme with extended chemical functionality. J. Am. Chem. Soc.
122(11): 2433-9.
783. Saphire ACS, Bobardt MD, Gallay PA. (2000) Human immunodeficieney virus
type 1 hijacks host cyclophilin a for its attachment to target cells. Immunol. Res. 21(2-3):
211-7.
784. Saphire ACS, Guan TL, Schirmer EC, Nemerow GR, Gerace L. (2000) Nuclear
import adenovirus DNA in vitro involves the nuclear protein import pathway and hsc70.
J. Biol. Chem. 275(6): 4298-304.
785. Scheffler G, Seike H, Sorensen EJ. (2000) An enantiospecific synthesis of the
potent immunosuppressant fr901483. Angew. Chem.-Int. Edit. 39(24): 4593-+.
786. Schwarzinger S, Kroon GJA, Foss TR, Wright PE, Dyson HJ. (2000) Random coil
chemical shifts in acidic 8 m urea: Implementation of random coil shift data in nmrview.
J. Biomol. NMR. 18(1): 43-8.
787. Shan WS, Tanaka H, Phillips GR, Arndt K, Yoshida M, Colman DR, Shapiro L.
(2000) Functional cis-heterodimers of n- and r-cadherins. J. Cell Biol. 148(3): 579-90.
788. Sheinerman FB, Norel R, Honig B. (2000) Electrostatic aspects of protein-protein
interactions. Curr. Opin. Struct. Biol. 10(2): 153-9.
789. Simeonov A, Matsushita M, Juban EA, Thompson EHZ, Hoffman TZ, Beuscher
AE, Taylor MJ, Wirsching P, Rettig W, McCusker JK, Stevens RC, Millar DP, Schultz
PG, Lerner RA, Janda KD. (2000) Blue-fluorescent antibodies. Science. 290(5490):
307-13.
790. Smith JA, Bifulco G, Case DA, Boger DL, Gomez-Paloma L, Chazin WJ. (2000)
The structural basis for in situ activation of DNA alkylation by duocarmycin sa. J. Mol.
Biol. 300(5): 1195-204.
791. Smith RS, Hawes NL, Chang B, Roderick TH, Akeson EC, Heckenlively JR,
Gong XH, Wang X, Davisson MT. (2000) Lop12, a mutation in mouse crygd causing
lens opacity similar to human coppock cataract. Genomics. 63(3): 314-20.
792. Stahl S, Tillyer R, King A, Dagneau P, Wang X, O'Shea P, Greasham R,
Chartrain M. (2000) Asymmetric bioreduction of an allylic ketosulfone to its
corresponding (r)-alcohol. Biocatal. Biotransform. 18(6): 471-7.
793. Stratmann T, Apostolopoulos V, Mallet-Designe V, Corper AL, Scott CA, Wilson
IA, Kang AS, Teyton L. (2000) The i-a(g7) mhc class ii molecule linked to murine
diabetes is a promiscuous peptide binder. J. Immunol. 165(6): 3214-25.
794. Strayer C, Oyama T, Schultz TF, Raman R, Somers DE, Mas P, Panda S, Kreps

JA, Kay SA. (2000) Cloning of the arabidopsis clock cone toc1, an autoregulatory
response regulator homolog. Science. 289(5480): 768-71.
795. Sucheck SJ, Wong AL, Koeller KM, Boehr DD, Draker K, Sears P, Wright GD,
Wong CH. (2000) Design of bifunctional antibiotics that target bacterial rrna and inhibit
resistance-causing enzymes. J. Am. Chem. Soc. 122(21): 5230-1.
796. Tamiya J, Sorensen EJ. (2000) A concise synthesis of (-)-hispidospermidin
guided by a postulated biogenesis. J. Am. Chem. Soc. 122(39): 9556-7.
797. Tanaka H, Shan WS, Phillips GR, Arndt K, Bozdagi O, Shapiro L, Huntley GW,
Benson DL, Colman DR. (2000) Molecular modification of n-cadherin in response to
synaptic activity. Neuron. 25(1): 93-107.
798. Tao Y, Yuan FH, Leister RT, Ausubel FM, Katagiri F. (2000) Mutational analysis
of the arabidopsis nucleotide binding site-leucine-rich repeat resistance gene rps2. Plant
Cell. 12(12): 2541-54.
799. Taylor KM, Lin TW, Porta C, Mosser AG, Giesing HA, Lomonossoff GP, Johnson
JE. (2000) Influence of three-dimensional structure on the immunogenicity of a peptide
expressed on the surface of a plant virus. J. Mol. Recognit. 13(2): 71-82.
800. Tcheng JE, O'Shea JC, Cohen EA, Pacchiana CM, Kitt MM, Lorenz TJ,
Greenberg S, Strony J, Califf RM, Buller C, Cantor WJ, Joseph DM, Lincoff AM, Madan
M, Popma J, Teirstein P, Cohen E, Balleza L, Parsons P, Lui H, Young J, Fox R,
Labinaz M, Jelley J, Williams J, Cohen D, Trovato M, Smith J, Henry P, Chisholm R,
O'Donnell D, Talley JD, Pacheco R, Timmis S, Muraka A, Mann T, Cubeddu G,
Tannenbaum M, Greene J, Santoian E, Wash M, Sheldon S, Pronesti L, Jain A, Alonzo
M, Seidelin P, Richards J, Lopez M, Dittenber R, Johnson K, Levine G, Maresh K,
Ferrando T, Sarembock I, Snyder L, Kieval J, Herlan L, Miller M, Bembridge D, Nair R,
Hickel L, Kiernan F, Murphy D, Cloutier J, Conn E, Beardsley J, Ritchie M, Cragen D,
Jafar MZ, Counihan P, Rosenfelder D, Ducas J, Montebruno L, Carere R, Radons B,
Williams L, Owens W, Dougal R, Feldman R, Audrain D, Karamali A, Smith M,
Blankenship J, Demko SL, Thompson M, Gacoich G, Chiodo V, Noll P, Ledley G, Miller
C, Felten W, Garner B, Chandler AB, Easler P, Albin G, Page A, Maddox W, Allen S,
Gilchrist I, Moore R, Zimmerman H, Curtis M, Hildebrand K, Greene R, Healy E,
Meengs W, Carson D, George J, Roncevich T, Aharonian V, Browning R, Kostuk W,
Carr S, Feit F, Gostomsky B, Butman S, Hannah E, Hassel CD, Hartley D, Shook T,
Hiller-Mullin S, Brill D, Dillion M, Armstrong B, Kerns D, Pichard A, Okubagzi P, Nasser
T, Driver L, Garrett J, Boltey L, Stouffer G, Potter M, Amidon T, Eggert S, Taussig A,
Potter K, Natarajan M, Tartaglia C, Werner J, Dunlap T, Harrold-Runge P, Davidson C,
Goodreau L, Herzog W, Calamunci N, Slater A, Tormey D, Phillips W, White D, Sridhar
K, White J, Goodman D, Buchbinder M, Nasser V, Rapeport K, Vorman P, Weiner B,
Borbone M, Shadoff N, Paap C, Rehman A, Haag E, Burchenal J, Kioussopoulos K,
Senior D, Senior J, Piana R, Kirshenbaum J, Chan S, Chowdry A, Kraft P, Clark V, Fox
M, Deutsch E, Shannon T, Quesada R, Brotherton J, Murrin C, Cinderella J, Hearne S,
Seefried V, Farah T, Pakstis D, Bartolet B, Bond C, Debarardinis C, Montory D, Smith
G, Gray D, Phillips P, Hathaway S, Manoukian S, Patrick C, Yakubov S, Brooks J, Block
P, Block B, Muhlestein JB, Kim S, Shalev Y, Schmidt W, Resar J, Citro K, Stine R,
Zumbuhl J, Moreyra A, Kreiger S, Berger P, Cannon CP, Fisher L, Hasselblad V, Foster

A, Joseph D, McLendon C, Rund M, Tillery N, Wood F, Mahaffey KW, Irwin C, Kulick D,
Johnson N, Chen J, Hogeboom C, Terifay R, Veltri E, Investigators E. (2000) Novel
dosing regimen of eptifibatide in planned coronary stent implantation (esprit): A
randomised, placebo-controlled trial. Lancet. 356(9247): 2037-44.
801. Toker JD, Wentworth P, Hu YF, Houk KN, Janda KD. (2000) Antibody-catalysis
of a bimolecular asymmetric 1,3-dipolar cycloaddition reaction. J. Am. Chem. Soc.
122(13): 3244-5.
802. Tsui V, Case DA. (2000) Theory and applications of the generalized born
solvation model in macromolecular simulations. Biopolymers. 56(4): 275-91.
803. Tsui V, Case DA. (2000) Molecular dynamics simulations of nucleic acids with a
generalized born solvation model. J. Am. Chem. Soc. 122(11): 2489-98.
804. Tsui V, Radhakrishnan I, Wright PE, Case DA. (2000) Nmr and molecular
dynamics studies of the hydration of a zinc finger-DNA complex. J. Mol. Biol. 302(5):
1101-17.
805. Tsui V, Zhu LM, Huang TH, Wright PE, Case DA. (2000) Assessment of zinc
finger orientations by residual dipolar coupling constants. J. Biomol. NMR. 16(1): 9-21.
806. Turner JM, Bui T, Lerner RA, Barbas CF, List B. (2000) An efficient benchtop
system for multigram-scale kinetic resolutions using aldolase antibodies. Chem.-Eur. J.
6(15): 2772-4.
807. Turner RJ, Lovato M, Schimmel P. (2000) One of two genes encoding glycyl-trna
synthetase in saccharomyces cerevisiae provides mitochondrial and cytoplasmic
functions. J. Biol. Chem. 275(36): 27681-8.
808. Vieth M, Cummins DJ. (2000) Domcosar: A novel approach for establishing the
docking mode that is consistent with the structure-activity relationship. Application to
hiv-1 protease inhibitors and vegf receptor tyrosine kinase inhibitors. J. Med. Chem.
43(16): 3020-32.
809. Vitart V, Christodoulou J, Huang JF, Chazin WJ, Harper JF. (2000)
Intramolecular activation of a ca2+-dependent protein kinase is disrupted by insertions
in the tether that connects the calmodulin-like domain to the kinase. Biochemistry.
39(14): 4004-11.
810. Wang EW, Kessler BM, Borodovsky A, Cravatt BF, Bogyo M, Ploegh HL, Glas R.
(2000) Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase
activity. Proc. Natl. Acad. Sci. U. S. A. 97(18): 9990-5.
811. Wang HS, Lim KL, Yeo SL, Xu XL, Sim MM, Ting AE, Wang Y, Yee S, Tan YH,
Pallen CJ. (2000) Isolation of a novel protein tyrosine phosphatase inhibitor, 2-methylfervenulone,
and its precursors from streptomyces. J. Nat. Prod. 63(12): 1641-6.
812. Wilson-Kubalek EM. (2000) Preparation of functionalized lipid tubules for electron
crystallography of macromolecules. Methods Enzymol. 312: 515-9.
813. Winston RL, Ehley JA, Baird EE, Dervan PB, Gottesfeld JM. (2000) Asymmetric
DNA binding by a homodimeric bhlh protein. Biochemistry. 39(31): 9092-8.
814. Winston RL, Gottesfeld JM. (2000) Rapid identification of key amino-acid-DNA
contacts through combinatorial peptide synthesis. Chem. Biol. 7(4): 245-51.
815. Wittmann V, Datta AK, Koeller KM, Wong CH. (2000) Chemoenzymatic synthesis
and fluorescent visualization of cell-surface selectin-bound sialyl lewis x derivatives.

Chem.-Eur. J. 6(1): 162-71.
816. Woo MK, Lee A, Fischer RS, Moyer J, Fowler VM. (2000) The lens membrane
skeleton contains structures preferentially enriched in spectrin-actin or tropomodulinactin
complexes. Cell Motil. Cytoskeleton. 46(4): 257-68.
817. Zhou ZS, Smith AE, Matthews RG. (2000) L-selenohomocysteine: One-step
synthesis from l-selenomethionine and kinetic analysis as substrate for methionine
synthases. Bioorg. Med. Chem. Lett. 10(21): 2471-5.
818. Adam GC, Cravatt BF, Sorensen EJ. (2001) Profiling the specific reactivity of the
proteome with non-directed activity-based probes. Chem. Biol. 8(1): 81-95.
819. Al-Lazikani B, Sheinerman FB, Honig B. (2001) Combining multiple structure and
sequence alignments to improve sequence detection and alignment: Application to the
sh2 domains of janus kinases. Proc. Natl. Acad. Sci. U. S. A. 98(26): 14796-801.
820. Aoyagi M, Arvai AS, Ghosh S, Stuehr DJ, Tainer JA, Getzoff ED. (2001)
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase
oxygenase dimer and implicated roles of trp457. Biochemistry. 40(43): 12826-32.
821. Aridor M, Fish KN, Bannykh S, Weissman J, Roberts TH, Lippincott-Schwartz J,
Balch WE. (2001) The sar1 gtpase coordinates biosynthetic cargo selection with
endoplasmic reticulum export site assembly. J. Cell Biol. 152(1): 213-29.
822. Avila-Sakar AJ, Misaghi S, Wilson-Kubalek EM, Downing KH, Zgurskaya H,
Nikaido H, Nogales E. (2001) Lipid-layer crystallization and preliminary threedimensional
structural analysis of acra, the periplasmic component of a bacterial
multidrug efflux pump. J. Struct. Biol. 136(1): 81-8.
823. Bailey MF, Thompson EHZ, Millar DP. (2001) Probing DNA polymerase fidelity
mechanisms using time-resolved fluorescence anisotropy. Methods. 25(1): 62-77.
824. Baldo GJ, Gong XH, Martinez-Wittinghan FJ, Kumar NM, Gilula NB, Mathias RG.
(2001) Gap junctional coupling in lenses from alpha(8) connexin knockout mice. J. Gen.
Physiol. 118(5): 447-56.
825. Barbas CF, Rader C, Segal DJ, List B, Turner JM. (2001) From catalytic
asymmetric synthesis to the transcriptional regulation of genes: In vivo and in vitro
evolution of proteins. Adv. Protein Chem. 55: 317-66.
826. Bark SJ, Muster N, Yates JR, Siuzdak G. (2001) High-temperature protein mass
mapping using a thermophilic protease. J. Am. Chem. Soc. 123(8): 1774-5.
827. Beck ZQ, Lin PC, Elder JH. (2001) Molecular basis for the relative substrate
specificity of human immunodeficiency virus type 1 and feline immunodeficiency virus
proteases. J. Virol. 75(19): 9458-69.
828. Berkowitz JKM, Catz SD, Johnson JL, Ruedi JM, Thon V, Babior BM. (2001)
Jfc1, a novel tandem c2 domain-containing protein associated with the leukocyte nadph
oxidase. J. Biol. Chem. 276(22): 18855-62.
829. Bilwes AM, Quezada CM, Croal LR, Crane BR, Simon MI. (2001) Nucleotide
binding by the histidine kinase chea. Nat. Struct. Biol. 8(4): 353-60.
830. Boger DL, Brunette SR, Garbaccio RM. (2001) Synthesis and evaluation of a
series of c3-substituted cbi analogues of cc-1065 and the duocarmycins. J. Org. Chem.
66(15): 5163-73.
831. Boger DL, Fink BE, Brunette SR, Tse WC, Hedrick MP. (2001) A simple, high-

esolution method for establishing DNA binding affinity and sequence selectivity. J. Am.
Chem. Soc. 123(25): 5878-91.
832. Boger DL, Goldberg J. (2001) Cytokine receptor dimerization and activation:
Prospects for small molecule agonists. Bioorg. Med. Chem. 9(3): 557-62.
833. Boger DL, Goldberg J, Silletti S, Kessler T, Cheresh DA. (2001) Identification of a
novel class of small-molecule antiangiogenic agents through the screening of
combinatorial libraries which function by inhibiting the binding and localization of
proteinase mmp2 to integrin alpha(v)beta(3). J. Am. Chem. Soc. 123(7): 1280-8.
834. Boger DL, Hong JY. (2001) Asymmetric total synthesis of ent-(-)-roseophilin:
Assignment of absolute configuration. J. Am. Chem. Soc. 123(35): 8515-9.
835. Boger DL, Ichikawa S, Tse WC, Hedrick MP, Jin Q. (2001) Total syntheses of
thiocoraline and be-22179 and assessment of their DNA binding and biological
properties. J. Am. Chem. Soc. 123(4): 561-8.
836. Boger DL, Kim SH, Mori Y, Weng JH, Rogel O, Castle SL, McAtee JJ. (2001)
First and second generation total synthesis of the teicoplanin aglycon. J. Am. Chem.
Soc. 123(9): 1862-71.
837. Boger DL, Tse WC. (2001) Thiazole orange as the fluorescent intercalator in a
high resolution fid assay for determining DNA binding affinity and sequence selectivity of
small molecules. Bioorg. Med. Chem. 9(9): 2511-8.
838. Bong DT, Clark TD, Granja JR, Ghadiri MR. (2001) Self-assembling organic
nanotubes. Angew. Chem.-Int. Edit. 40(6): 988-1011.
839. Bong DT, Ghadiri MR. (2001) Self-assembling cyclic peptide cylinders as nuclei
for crystal engineering. Angew. Chem.-Int. Edit. 40(11): 2163-6.
840. Bong DT, Ghadiri MR. (2001) Chemoselective pd(0)-catalyzed peptide coupling
in water. Org. Lett. 3(16): 2509-11.
841. Bruick RK, McKnight SL. (2001) Building better vasculature. Genes Dev. 15(19):
2497-502.
842. Bruick RK, McKnight SL. (2001) A conserved family of prolyl-4-hydroxylases that
modify hif. Science. 294(5545): 1337-40.
843. Burton DR, Saphire EO, Parren P. (2001) A model for neutralization of viruses
based on antibody coating of the virion surface. Curr. Top. Microbiol. Immunol. 260:
109-43.
844. Carrera MRA, Ashley JA, Wirsching P, Koob GF, Janda KD. (2001) A secondgeneration
vaccine protects against the psychoactive effects of cocaine. Proc. Natl.
Acad. Sci. U. S. A. 98(4): 1988-92.
845. Chai Q, Qiu J, Chapados BR, Shen BH. (2001) Archaeoglobus fulgidus rnase hii
in DNA replication: Enzymological functions and activity regulation via metal cofactors.
Biochem. Biophys. Res. Commun. 286(5): 1073-81.
846. Chang G, Roth CB. (2001) Structure of msba from e-coli: A homolog of the
multidrug resistance atp binding cassette (abc) transporters. Science. 293(5536): 1793-
800.
847. Chang YT, Wignall SM, Rosania GR, Gray NS, Hanson SR, Su AI, Merlie J,
Moon HS, Sangankar SB, Perez O, Heald R, Schultz PG. (2001) Synthesis and
biological evaluation of myoseverin derivatives: Microtubule assembly inhibitors. J. Med.

Chem. 44(26): 4497-500.
848. Chapados BR, Chai Q, Hosfield DJ, Qiu JZ, Shen BH, Tainer JA. (2001)
Structural biochemistry of a type 2 rnase h: Rna primer recognition and removal during
DNA replication. J. Mol. Biol. 307(2): 541-56.
849. Chen BC, Ngu K, Guo P, Liu W, Sundeen JE, Weinstein DS, Atwal KS, Ahmad S.
(2001) A new facile method for the stereoselective synthesis of trans-2-aryl-3,3dimethylcyclopropane-1-carboxylic
acids. Tetrahedron Lett. 42(36): 6227-9.
850. Chen CD, Huff ME, Matteson J, Page L, Phillips R, Kelly JW, Balch WE. (2001)
Furin initiates gelsolin familial amyloidosis in the golgi through a defect in ca2+
stabilization. Embo J. 20(22): 6277-87.
851. Chen HW, Thomas MG, O'Connor SE, Hubbard BK, Burkart MD, Walsh CT.
(2001) Aminoacyl-s-enzyme intermediates in beta-hydroxylations and alpha,betadesaturations
of amino acids in peptide antibiotics. Biochemistry. 40(39): 11651-9.
852. Chiu CY, Wu E, Brown SL, Von Seggern DJ, Nemerow GR, Stewart PL. (2001)
Structural analysis of a fiber-pseudotyped adenovirus with ocular tropism suggests
differential modes of cell receptor interactions. J. Virol. 75(11): 5375-80.
853. Clark D, Travis DA. (2001) An enantioselective synthesis of insecticidal 4alkynyloxazolines.
Bioorg. Med. Chem. 9(11): 2857-62.
854. Clark TD, Tien J, Duffy DC, Paul KE, Whitesides GM. (2001) Self-assembly of
10-mu m-sized objects into ordered three-dimensional arrays. J. Am. Chem. Soc.
123(31): 7677-82.
855. Cohen A, Ellis P, Kresge N, Soltis SM. (2001) Mad phasing with krypton. Acta
Crystallogr. Sect. D-Biol. Crystallogr. 57: 233-8.
856. Cohen A, Yohn CB, Mayfield SP. (2001) Translation of the chloroplast-encoded
psbd mrna is arrested post-initiation in a nuclear mutant of chlamydomonas reinhardtii.
J. Plant Physiol. 158(8): 1069-75.
857. Colacino E, Converso A, Liguori A, Napoli A, Siciliano C, Sindona G. (2001)
Simple and efficient routes for the preparation of isoxazolidinyl nucleosides containing
cytosine and 5-methyl-cytosine as new potential anti-hiv drugs. Tetrahedron. 57(40):
8551-7.
858. Converso A, Burow K, Marzinzik A, Sharpless KB, Finn MG. (2001) 2,6-dichloro-
9-thiabicyclo[3.3.1]nonane: A privileged, bivalent scaffold for the display of nucleophilic
components. J. Org. Chem. 66(12): 4386-92.
859. Covington MF, Panda S, Liu XL, Strayer CA, Wagner DR, Kay SA. (2001) Elf3
modulates resetting of the circadian clock in arabidopsis. Plant Cell. 13(6): 1305-15.
860. Crane BR, Di Bilio AJ, Winkler JR, Gray HB. (2001) Electron tunneling in single
crystals of pseudomonas aeruginosa azurins. J. Am. Chem. Soc. 123(47): 11623-31.
861. Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR,
Lichtman AH. (2001) Supersensitivity to anandamide and enhanced endogenous
cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc. Natl. Acad. Sci.
U. S. A. 98(16): 9371-6.
862. Damke H, Muhlberg AB, Sever S, Sholly S, Warnock DE, Schmid SL. (2001)
Expression, purification, and functional assays for self-association of dynamin-1.
Methods Enzymol. 329: 447-57.

863. Demko ZP, Sharpless KB. (2001) Preparation of 5-substituted 1h-tetrazoles from
nitriles in water. J. Org. Chem. 66(24): 7945-50.
864. Demko ZP, Sharpless KB. (2001) An intramolecular [2+3] cycloaddition route to
fused 5-heterosubstituted tetrazoles. Org. Lett. 3(25): 4091-4.
865. Di Bilio AJ, Crane BR, Wehbi WA, Kiser CN, Abu-Omar MM, Carlos RM,
Richards JH, Winkler JR, Gray HB. (2001) Properties of photogenerated tryptophan and
tyrosyl radicals in structurally characterized proteins containing rhenium(i) tricarbonyl
diimines. J. Am. Chem. Soc. 123(13): 3181-2.
866. Dickerson TJ, Reed NN, Janda KD. (2001) Regio-reactive resin: A platform for
orthogonal loading using the polymer backbone and cross-linker. Bioorg. Med. Chem.
Lett. 11(12): 1507-9.
867. Ding S, Gray NS, Ding Q, Schultz PG. (2001) A concise and traceless linker
strategy toward combinatorial libraries of 2,6,9-substituted purines. J. Org. Chem.
66(24): 8273-6.
868. Ding S, Gray NS, Ding Q, Schultz PG. (2001) Expanding the diversity of purine
libraries. Tetrahedron Lett. 42(50): 8751-5.
869. Doring V, Mootz HD, Nangle LA, Hendrickson TL, de Crecy-Lagard V, Schimmel
P, Marliere P. (2001) Enlarging the amino acid set of escherichia coli by infiltration of the
valine coding pathway. Science. 292(5516): 501-4.
870. Dunn AR, Dmochowski IJ, Bilwes AM, Gray HB, Crane BR. (2001) Probing the
open state of cytochrome p450cam with ruthenium-linker substrates. Proc. Natl. Acad.
Sci. U. S. A. 98(22): 12420-5.
871. Ellis DA, Wolkenberg SE, Boger DL. (2001) Metal cation complexation and
activation of reversed cpyi analogues of cc-1065 and duocarmycin sa: Partitioning the
effects of binding and catalysis. J. Am. Chem. Soc. 123(38): 9299-306.
872. Fast J, Hakansson M, Muranyi A, Gippert GP, Thulin E, Evenas J, Svensson LA,
Linse S. (2001) Symmetrical stabilization of bound ca2+ ions in a cooperative pair of efhands
through hydrogen bonding of coordinating water molecules in calbindin d-9k.
Biochemistry. 40(33): 9887-95.
873. Fernandez-Lopez S, Kim HS, Choi EC, Delgado M, Granja JR, Khasanov A,
Kraehenbuehl K, Long G, Weinberger DA, Wilcoxen KM, Ghadiri MR. (2001)
Antibacterial agents based on the cyclic d,l-alpha-peptide architecture. Nature.
412(6845): 452-5.
874. Garbaccio RM, Stachel SJ, Baeschlin DK, Danishefsky SJ. (2001) Concise
asymmetric syntheses of radicicol and monocillin i. J. Am. Chem. Soc. 123(44): 10903-
8.
875. Gong XH, Weng X, Han JH, Niesman I, Huang QL, Horwitz J. (2001)
Development of cataractous macrophthalmia in mice expressing an active mek1 in the
lens. Invest. Ophthalmol. Vis. Sci. 42(3): 539-48.
876. Greasley SE, Marsilje TH, Cai H, Baker S, Benkovic SJ, Boger DL, Wilson IA.
(2001) Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on
the active site of gar transformylase. Biochemistry. 40(45): 13538-47.
877. Gupta D, Treon SP, Shima Y, Hideshima T, Podar K, Tai YT, Lin B, Lentzsch S,
Davies FE, Chauhan D, Schlossman RL, Richardson P, Ralph P, Wu L, Payvandi F,

Muller G, Stirling DI, Anderson KC. (2001) Adherence of multiple myeloma cells to bone
marrow stromal cells upregulates vascular endothelial growth factor secretion:
Therapeutic applications. Leukemia. 15(12): 1950-61.
878. Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R,
Navarre J, Chan EKL, Lapierre LA, Goldenring JR. (2001) Identification and
characterization of a family of rab11-interacting proteins. J. Biol. Chem. 276(42): 39067-
75.
879. Hammarstrom P, Jiang X, Deechongkit S, Kelly JW. (2001) Anion shielding of
electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into
the chaotrope unfolding dichotomy. Biochemistry. 40(38): 11453-9.
880. Harmer SL, Panda S, Kay SA. (2001) Molecular bases of circadian rhythms.
Annu. Rev. Cell Dev. Biol. 17: 215-53.
881. Harris JL, Alper PB, Li J, Rechsteiner M, Backes BJ. (2001) Substrate specificity
of the human proteasome. Chem. Biol. 8(12): 1131-41.
882. Hartgerink JD, Beniash E, Stupp SI. (2001) Self-assembly and mineralization of
peptide-amphiphile nanofibers. Science. 294(5547): 1684-8.
883. Hartgerink JD, Zubarev ER, Stupp SI. (2001) Supramolecular one-dimensional
objects. Curr. Opin. Solid State Mat. Sci. 5(4): 355-61.
884. Hearn AS, Stroupe ME, Cabelli DE, Lepock JR, Tainer JA, Nick HS, Silverman
DN. (2001) Kinetic analysis of product inhibition in human manganese superoxide
dismutase. Biochemistry. 40(40): 12051-8.
885. Hedley WJ, Nelson MR, Bullivant DP, Nielsen PF. (2001) A short introduction to
cellml. Philos. Trans. R. Soc. Lond. Ser. A-Math. Phys. Eng. Sci. 359(1783): 1073-89.
886. Heine A, DeSantis G, Luz JG, Mitchell M, Wong CH, Wilson IA. (2001)
Observation of covalent intermediates in an enzyme mechanism at atomic resolution.
Science. 294(5541): 369-74.
887. Hernandez J, Aung S, Redmond WL, Sherman LA. (2001) Phenotypic and
functional analysis of cd8(+) t cells undergoing peripheral deletion in response to crosspresentation
of self-antigen. J. Exp. Med. 194(6): 707-17.
888. Hirst J, Wilcox SK, Ai JY, Moenne-Loccoz P, Loehr TM, Goodin DB. (2001)
Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2.
Effects on heme coordination and function. Biochemistry. 40(5): 1274-83.
889. Hirst J, Wilcox SK, Williams PA, Blankenship J, McRee DE, Goodin DB. (2001)
Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1.
Effects on structure. Biochemistry. 40(5): 1265-73.
890. Hof F, Iovine PM, Johnson DW, Rebek J. (2001) Highly selective synthesis of
heterosubstituted aromatic sulfamides. Org. Lett. 3(26): 4247-9.
891. Hof F, Palmer LC, Rebek J. (2001) Synthesis and self-assembly of the "Tennis
ball" Dimer and subsequent encapsulation of methane - an advanced organic chemistry
laboratory experiment. J. Chem. Educ. 78(11): 1519-21.
892. Hogenesch JB, Ching KA, Batalov S, Su AI, Walker JR, Zhou YY, Kay SA,
Schultz PG, Cooke MP. (2001) A comparison of the celera and ensembl predicted gene
sets reveals little overlap in novel genes. Cell. 106(4): 413-5.
893. Holmlin RE, Chen XX, Chapman RG, Takayama S, Whitesides GM. (2001)

Zwitterionic sams that resist nonspecific adsorption of protein from aqueous buffer.
Langmuir. 17(9): 2841-50.
894. Hosfield DJ, Daniels DS, Mol CD, Putnam CD, Parikh SS, Tainer JA. (2001) DNA
damage recognition and repair pathway coordination revealed by the structural
biochemistry of DNA repair enzymes. Prog. Nucleic Acid Res. Mol. Biol. 68: 315-47.
895. Hotze EM, Wilson-Kubalek EM, Rossjohnn J, Parker MW, Johnson AE, Tweten
RK. (2001) Arresting pore formation of a cholesterol-dependent cytolysin by disulfide
trapping synchronizes the insertion of the transmembrane ss-sheet from a prepore
intermediate. J. Biol. Chem. 276(11): 8261-8.
896. Huang MD, Weissman JT, Beraud-Dufour S, Luan P, Wang CQ, Chen W, Aridor
M, Wilson IA, Balch WE. (2001) Crystal structure of sar1-gdp at 1.7 angstrom resolution
and the role of the nh2 terminus in er export. J. Cell Biol. 155(6): 937-48.
897. Huang XF, Witte KL, Bergbreiter DE, Wong CH. (2001) Homogenous enzymatic
synthesis using a thermo-responsive water-soluble polymer support. Adv. Synth. Catal.
343(6-7): 675-81.
898. Huitron-Resendiz S, Gombart L, Cravatt BF, Henriksen SJ. (2001) Effect of
oleamide on sleep and its relationship to blood pressure, body temperature, and
locomotor activity in rats. Exp. Neurol. 172(1): 235-43.
899. Jiang X, Smith CS, Petrassi HM, Hammarstrom P, White JT, Sacchettini JC,
Kelly JW. (2001) An engineered transthyretin monomer that is nonamyloidogenic,
unless it is partially denatured. Biochemistry. 40(38): 11442-52.
900. Johnson DS, Solomon AR, Washington CV. (2001)
Mucoepidermoid/adenosauamous carcinoma of the skin: Presentation of two cases.
Dermatologic Surgery. 27(12): 1046-8.
901. Kennan AJ, Haridas V, Severin K, Lee DH, Ghadiri MR. (2001) A de novo
designed peptide ligase: A mechanistic investigation. J. Am. Chem. Soc. 123(9): 1797-
803.
902. Kidd D, Liu YS, Cravatt BF. (2001) Profiling serine hydrolase activities in complex
proteomes. Biochemistry. 40(13): 4005-15.
903. Koeller KM, Wong CH. (2001) Enzymes for chemical synthesis. Nature.
409(6817): 232-40.
904. Kozlov IA, Mao SL, Xu Y, Huang XF, Lee L, Sears PS, Gao CS, Coyle AR, Janda
KD, Wong CH. (2001) Synthesis of solid-supported mirror-image sugars: A novel
method for selecting receptors for cellular-surface carbohydrates. Chembiochem. 2(10):
741-6.
905. Kresge N, Vacquier VD, Stout CD. (2001) The crystal structure of a fusagenic
sperm protein reveals extreme surface properties. Biochemistry. 40(18): 5407-13.
906. Kresge N, Vacquier VD, Stout CD. (2001) Abalone lysin: The dissolving and
evolving sperm protein. Bioessays. 23(1): 95-103.
907. Larsen NA, Heine A, Crane L, Cravatt BF, Lerner RA, Wilson IA. (2001)
Structural basis for a disfavored elimination reaction in catalytic antibody 1d4. J. Mol.
Biol. 314(1): 93-102.
908. Larsen NA, Zhou B, Heine A, Wirsching P, Janda KD, Wilson IA. (2001) Crystal
structure of a cocaine-binding antibody. J. Mol. Biol. 311(1): 9-15.

909. Lee A, Morrow JS, Fowler VM. (2001) Caspase remodeling of the spectrin
membrane skeleton during lens development and aging. J. Biol. Chem. 276(23): 20735-
42.
910. Lin PS, Lee CL, Sim MM. (2001) Synthesis of novel guanidinoglycoside: 2glycosylamino
4,5-dihydro-6-pyrimidinone. J. Org. Chem. 66(24): 8243-7.
911. Littlefield R, Almenar-Queralt A, Fowler VM. (2001) Actin dynamics at pointed
ends regulates thin filament length in striated muscle. Nat. Cell Biol. 3(6): 544-51.
912. Liu HT, Sadamoto R, Sears PS, Wong CH. (2001) An efficient chemoenzymatic
strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall
precursors: Udp-n-acetylmuramyl-peptides. J. Am. Chem. Soc. 123(40): 9916-7.
913. Liu JJ, Shikhman AR, Lotz MK, Wong CH. (2001) Hexosaminidase inhibitors as
new drug candidates for the therapy of osteoarthritis. Chem. Biol. 8(7): 701-11.
914. Lopez-Girona A, Tanaka K, Chen XB, Baber BA, McGowan CH, Russell P.
(2001) Serine-345 is required for rad3-dependent phosphorylation and function of
checkpoint kinase chk1 in fission yeast. Proc. Natl. Acad. Sci. U. S. A. 98(20): 11289-
94.
915. Lovato MA, Chihade JW, Schimmel P. (2001) Translocation within the acceptor
helix of a major trna identity determinant. Embo J. 20(17): 4846-53.
916. Luo LS, Burkart MD, Stachelhaus T, Walsh CT. (2001) Substrate recognition and
selection by the initiation module pheate of gramicidin s synthetase. J. Am. Chem. Soc.
123(45): 11208-18.
917. MacBeath G. (2001) Proteomics comes to the surface - microarrays of purified
proteins, representing most of the yeast genome, prove useful for studying protein
function on a genome-wide scale. Nat. Biotechnol. 19(9): 828-9.
918. Macke TJ, Ecker DJ, Gutell RR, Gautheret D, Case DA, Sampath R. (2001)
Rnamotif, an rna secondary structure definition and search algorithm. Nucleic Acids
Res. 29(22): 4724-35.
919. MacMahon S, Fong R, Baran PS, Safonov I, Wilson SR, Schuster DI. (2001)
Synthetic approaches to a variety of covalently linked porphyrin-fullerene hybrids. J.
Org. Chem. 66(16): 5449-55.
920. Magliery TJ, Anderson JC, Schultz PG. (2001) Expanding the genetic code:
Selection of efficient suppressors of four-base codons and identification of "Shifty" Fourbase
codons with a library approach in escherichia coli. J. Mol. Biol. 307(3): 755-69.
921. Marinzi C, Bark SJ, Offer J, Dawson PE. (2001) A new scaffold for amide ligation.
Bioorg. Med. Chem. 9(9): 2323-8.
922. Marshall CG, Burkart MD, Keating TA, Walsh CT. (2001) Heterocycle formation
in vibriobactin biosynthesis: Alternative substrate utilization and identification of a
condensed intermediate. Biochemistry. 40(35): 10655-63.
923. Martin WL, West AP, Gan L, Bjorkman PJ. (2001) Crystal structure at 2.8
angstrom of an fcrn/heterodimeric fc complex: Mechanism of ph-dependent binding.
Mol. Cell. 7(4): 867-77.
924. Merlic CA, Aldrich CC, Albaneze-Walker J, Saghatelian A, Mammen J. (2001)
Total synthesis of the calphostins: Application of fischer carbene complexes and
thermodynamic control of atropisomers. J. Org. Chem. 66(4): 1297-309.

925. Mitchell M, Qaio L, Wong CH. (2001) Chemical-enzymatic synthesis of
iminocyclitol phosphonic acids. Adv. Synth. Catal. 343(6-7): 596-9.
926. Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D,
Stults JT, Stearns T. (2001) Gcp5 and gcp6: Two new members of the human gammatubulin
complex. Mol. Biol. Cell. 12(11): 3340-52.
927. Navarro M, Carrera MRA, Fratta W, Valverde O, Cossu G, Fattore L, Chowen JA,
Gomez R, del Arco I, Villanua MA, Maldonado R, Koob GF, de Fonseca FR. (2001)
Functional interaction between opioid and cannabinoid receptors in drug selfadministration.
J. Neurosci. 21(14): 5344-50.
928. Nicolaou KC, Baran PS, Kranich R, Zhong YL, Sugita K, Zou N. (2001)
Mechanistic studies of periodinane-mediated reactions of anilides and related systems.
Angew. Chem.-Int. Edit. 40(1): 202-6.
929. Nicolaou KC, Baran PS, Zhong YL. (2001) Selective oxidation at carbon adjacent
to aromatic systems with ibx. J. Am. Chem. Soc. 123(13): 3183-5.
930. Nicolaou KC, Boddy CNC. (2001) Behind lines. Sci.Am. 284(5): 54-61.
931. Nicolaou KC, Boddy CNC, Siegel JS. (2001) Does cip nomenclature adequately
handle molecules with multiple stereoelements? A case study of vancomycin and
cognates. Angew. Chem.-Int. Edit. 40(4): 701-4.
932. Nicolaou KC, Cho SY, Hughes R, Winssinger N, Smethurst C, Labischinski H,
Endermann R. (2001) Solid- and solution-phase synthesis of vancomycin and
vancomycin analogues with activity against vancomycin-resistant bacteria. Chem.-Eur.
J. 7(17): 3798-823.
933. Nicolaou KC, Gray D. (2001) Total synthesis of hybocarpone. Angew. Chem.-Int.
Edit. 40(4): 761-3.
934. Nicolaou KC, Gray D, Tae JS. (2001) Total synthesis of hamigerans: Part 1.
Development of synthetic technology for the construction of benzannulated polycyclic
systems by the intramolecular trapping of photogenerated hydroxy-o-quinodimethanes
and synthesis of key building blocks. Angew. Chem.-Int. Edit. 40(19): 3675-+.
935. Nicolaou KC, Gray D, Tae JS. (2001) Total synthesis of hamigerans: Part 2.
Implementation of the intramolecular diels-alder trapping of photochemically generated
hydroxy-o-quinodimethanes; strategy and completion of the synthesis. Angew. Chem.-
Int. Edit. 40(19): 3679-+.
936. Nicolaou KC, Huang X, Giuseppone N, Rao PB, Bella M, Reddy MV, Snyder SA.
(2001) Construction of the complete aromatic core of diazonamide a by a novel hetero
pinacol macrocyclization cascade reaction. Angew. Chem.-Int. Edit. 40(24): 4705-+.
937. Nicolaou KC, Hughes R, Cho SY, Winssinger N, Labischinski H, Endermann R.
(2001) Synthesis and biological evaluation of vancomycin dimers with potent activity
against vancomycin-resistant bacteria: Target-accelerated combinatorial synthesis.
Chem.-Eur. J. 7(17): 3824-43.
938. Nicolaou KC, Hughes R, Pfefferkorn JA, Barluenga S. (2001) Optimization and
mechanistic studies of psammaplin a type antibacterial agents active against methicillinresistant
staphylococcus aureus (mrsa). Chem.-Eur. J. 7(19): 4296-310.
939. Nicolaou KC, Hughes R, Pfefferkorn JA, Barluenga S, Roecker AJ. (2001)
Combinatorial synthesis through disulfide exchange: Discovery of potent psammaplin a

type antibacterial agents active against methicillin-resistant staphylococcus aureus
(mrsa). Chem.-Eur. J. 7(19): 4280-95.
940. Nicolaou KC, Li YW, Fylaktakidou KC, Mitchell HJ, Sugita K. (2001) Total
synthesis of apoptolidin: Part 2. Coupling of key building blocks and completion of the
synthesis. Angew. Chem.-Int. Edit. 40(20): 3854-+.
941. Nicolaou KC, Namoto K, Li J, Ritzen A, Ulven T, Shoji M, Zaharevitz D, Gussio R,
Sackett DL, Ward RD, Hensler A, Fojo T, Giannakakou P. (2001) Synthesis and
biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones.
Chembiochem. 2(1): 69-75.
942. Nicolaou KC, Namoto K, Ritzen A, Ulven T, Shoji M, Li J, D'Amico G, Liotta D,
French CT, Wartmann M, Altmann KH, Giannakakou P. (2001) Chemical synthesis and
biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl
epothilones and related pyridine side chain analogues. J. Am. Chem. Soc. 123(38):
9313-23.
943. Nicolaou KC, Pfefferkorn JA. (2001) Solid phase synthesis of complex natural
products and libraries thereof. Biopolymers. 60(3): 171-93.
944. Nicolaou KC, Pihko PM, Diedrichs N, Zou N, Bernal F. (2001) Synthesis of the
fghi ring system of azaspiracid. Angew. Chem.-Int. Edit. 40(7): 1262-+.
945. Nicolaou KC, Qian WY, Bernal F, Uesaka N, Pihko PM, Hinrichs J. (2001)
Synthesis of the abcd ring system of azaspiracid. Angew. Chem.-Int. Edit. 40(21): 4068-
+.
946. Nicolaou KC, Ritzen A, Namoto K. (2001) Recent developments in the chemistry,
biology and medicine of the epothilones. Chem. Commun. (17): 1523-35.
947. Nicolaou KC, Roecker AJ, Barluenga S, Pfefferkorn JA, Cao GQ. (2001)
Discovery of novel antibacterial agents active against methicillin-resistant
staphylococcus aureus from combinatorial benzopyran libraries. Chembiochem. 2(6):
460-5.
948. Nicolaou KC, Safina BS, Winssinger N. (2001) A new photolabile linker for the
photoactivation of carboxyl groups. Synlett. 900-3.
949. Nicolaou KC, Sugita K, Baran PS, Zhong YL. (2001) New synthetic technology
for the construction of n-containing quinones and derivatives thereof: Total synthesis of
epoxyquinomycin b. Angew. Chem.-Int. Edit. 40(1): 207-10.
950. Nicolaou KC, Zhong YL, Baran PS, Sugita K. (2001) Rapid access to complex
molecular architectures via o-azaquinones. Angew. Chem.-Int. Edit. 40(11): 2145-9.
951. Niculescu AB, Akiskal HS. (2001) Proposed endophenotypes of dysthymia:
Evolutionary, clinical and pharmacogenomic considerations. Mol. Psychiatr. 6(4): 363-6.
952. Niculescu AB, Kelsoe JR. (2001) The human genome - genetic testing and
animal models. Am. J. Psychiat. 158(10): 1587-.
953. Niculescu AB, Kelsoe JR. (2001) Convergent functional genomics: Application to
bipolar disorder. Ann. Med. 33(4): 263-71.
954. Norel R, Sheinerman F, Petrey D, Honig B. (2001) Electrostatic contributions to
protein-protein interactions: Fast energetic filters for docking and their physical basis.
Protein Sci. 10(11): 2147-61.
955. Notz W, Sakthivel K, Bui T, Zhong GF, Barbas CF. (2001) Amine-catalyzed direct

asymmetric mannich-type reactions. Tetrahedron Lett. 42(2): 199-201.
956. Nunn RS, Macke TJ, Olson AJ, Yeager M. (2001) Transmembrane alpha-helices
in the gap junction membrane channel: Systematic search of packing models based on
the pair potential function. Microsc. Res. Tech. 52(3): 344-51.
957. Oliver SRJ, Clark TD, Bowden N, Whitesides GM. (2001) Three-dimensional selfassembly
of complex, millimeter-scale structures through capillary bonding. J. Am.
Chem. Soc. 123(33): 8119-20.
958. Orencia MC, Hanson MA, Stevens RC. (2001) Structural analysis of affinity
matured antibodies and laboratory-evolved enzymes. Adv. Protein Chem. 55: 227-59.
959. Ostuni E, Chapman RG, Holmlin RE, Takayama S, Whitesides GM. (2001) A
survey of structure-property relationships of surfaces that resist the adsorption of
protein. Langmuir. 17(18): 5605-20.
960. Patricelli MP, Cravatt BF. (2001) Characterization and manipulation of the acyl
chain selectivity of fatty acid amide hydrolase. Biochemistry. 40(20): 6107-15.
961. Patricelli MP, Cravatt BF. (2001) Proteins regulating the biosynthesis and
inactivation of neuromodulatory fatty acid amides. Vitamins and Hormones - Advances
in Research and Applications. 62: 95-131.
962. Patricelli MP, Giang DK, Stamp LM, Burbaum JJ. (2001) Direct visualization of
serine hydrolase activities in complex proteomes using fluorescent active site-directed
probes. Proteomics. 1(9): 1067-71.
963. Peariso K, Zhou ZHS, Smith AE, Matthews RG, Penner-Hahn JE. (2001)
Characterization of the zinc sites in cobalamin-independent and cobalamin-dependent
methionine synthase using zinc and selenium x-ray absorption spectroscopy.
Biochemistry. 40(4): 987-93.
964. Petrassi HM, Sharpless KB, Kelly JW. (2001) The copper-mediated cross
coupling of phenylboronic acids and n-hydroxyphthalimide at room temperature:
Synthesis of aryloxyamines. Org. Lett. 3(1): 139-42.
965. Petruccelli S, Dai S, Carcamo R, Yin YH, Chen SY, Beachy RN. (2001)
Transcription factor rf2a alters expression of the rice tungro bacilliform virus promoter in
transgenic tobacco plants. Proc. Natl. Acad. Sci. U. S. A. 98(13): 7635-40.
966. Phillips GR, Huang JK, Wang Y, Tanaka H, Shapiro L, Zhang WD, Shan WS,
Arndt K, Frank M, Gordon RE, Gawinowicz MA, Zhao YM, Colman DR. (2001) The
presynaptic particle web: Ultrastructure, composition, dissolution, and reconstitution.
Neuron. 32(1): 63-77.
967. Phoon CW, Ng PY, Ting AE, Yeo SL, Sim MM. (2001) Biological evaluation of
hepatitis c virus helicase inhibitors. Bioorg. Med. Chem. Lett. 11(13): 1647-50.
968. Phoon CW, Sim MM. (2001) Traceless synthesis of urea, semicarbazide and
carbamate derivatives using bromo-wang resin and bromo-wang synphase (tm) lantern.
Synlett. (5): 697-9.
969. Poignard P, Saphire EO, Parren P, Burton DR. (2001) Gp120: Biologic aspects of
structural features. Annu. Rev. Immunol. 19: 253-74.
970. Purkey HE, Dorrell MI, Kelly JW. (2001) Evaluating the binding selectivity of
transthyretin amyloid fibril inhibitors in blood plasma. Proc. Natl. Acad. Sci. U. S. A.
98(10): 5566-71.

971. Putnam CD, Clancy SB, Tsuruta H, Gonzalez S, Wetmur JG, Tainer JA. (2001)
Structure and mechanism of the ruvb holliday junction branch migration motor. J. Mol.
Biol. 311(2): 297-310.
972. Ratnaswamy G, Huff ME, Su AI, Rion S, Kelly JW. (2001) Destabilization of
ca2+-free gelsolin may not be responsible for proteolysis in familial amyloidosis of
finnish type. Proc. Natl. Acad. Sci. U. S. A. 98(5): 2334-9.
973. Ritter TK, Wong CH. (2001) Carbohydrate-based antibiotics: A new approach to
tackling the problem of resistance. Angew. Chem.-Int. Edit. 40(19): 3509-33.
974. Ritter TK, Wong CH. (2001) Synthesis of n-acetylglucosamine thiazoline/lipid ii
hybrids. Tetrahedron Lett. 42(4): 615-8.
975. Rouiller I, Pulokas J, Butel VM, Milligan RA, Wilson-Kubalek EM, Potter CS,
Carragher BO. (2001) Automated image acquisition for single-particle reconstruction
using p97 as the biological sample. J. Struct. Biol. 133(2-3): 102-7.
976. Ruiz-Taylor LA, Martin TL, Zaugg FG, Witte K, Indermuhle P, Nock S, Wagner P.
(2001) Monolayers of derivatized poly(l-lysine)-grafted poly(ethylene glycol) on metal
oxides as a class of biomolecular interfaces. Proc. Natl. Acad. Sci. U. S. A. 98(3): 852-7.
977. Saghatelian A, Buriak J, Lin VSY, Ghadiri MR. (2001) Transition metal mediated
surface modification of porous silicon. Tetrahedron. 57(24): 5131-6.
978. Saghatelian A, Yokobayashi Y, Soltani K, Ghadiri MR. (2001) A chiroselective
peptide replicator. Nature. 409(6822): 797-801.
979. Sanchez-Quesada J, Sun Kim H, Ghadiri MR. (2001) A synthetic pore-mediated
transmembrane transport of glutamic acid this work is supported by a grant from the
national institutes of health (grant: Gm52190). Angew. Chem. Int. Ed. Engl. 40(13):
2503-6.
980. Saphire ACS, Bobardt MD, Zhang Z, David G, Gallay PA. (2001) Syndecans
serve as attachment receptors for human immunodeficiency virus type 1 on
macrophages. J. Virol. 75(19): 9187-200.
981. Saphire EO, Parren P. (2001) Listening for viral infection - biosensors based on a
quartz crystal microbalance show promise for sensitive and rapid viral detection. Nat.
Biotechnol. 19(9): 823-4.
982. Saphire EO, Parren P, Barbas CF, Burton DR, Wilson IA. (2001) Crystallization
and preliminary structure determination of an intact human immunoglobulin, b12: An
antibody that broadly neutralizes primary isolates of hiv-1. Acta Crystallogr. Sect. D-Biol.
Crystallogr. 57: 168-71.
983. Saphire EO, Parren P, Pantophlet R, Zwick MB, Morris GM, Rudd PM, Dwek RA,
Stanfield RL, Burton DR, Wilson IA. (2001) Crystal structure of a neutralizing human igg
against hiv-1: A template for vaccine design. Science. 293(5532): 1155-9.
984. Schwarzinger S, Kroon GJA, Foss TR, Chung J, Wright PE, Dyson HJ. (2001)
Sequence-dependent correction of random coil nmr chemical shifts. J. Am. Chem. Soc.
123(13): 2970-8.
985. Sears P, Wong CH. (2001) Toward automated synthesis of oligosaccharides and
glycoproteins. Science. 291(5512): 2344-50.
986. Shang ML, Koshikawa N, Schenk S, Quaranta V. (2001) The lg3 module of
laminin-5 harbors a binding site for integrin alpha(3)beta(1) that promotes cell adhesion,

spreading, and migration. J. Biol. Chem. 276(35): 33045-53.
987. Silletti S, Kessler T, Goldberg J, Boger DL, Cheresh DA. (2001) Disruption of
matrix metalloproteinase 2 binding to integrin alpha(v)beta(3) by an organic molecule
inhibits angiogenesis and tumor growth in vivo. Proc. Natl. Acad. Sci. U. S. A. 98(1):
119-24.
988. Sing WT, Lee CL, Yeo SL, Lim SP, Sim MM. (2001) Arylalkylidene rhodanine
with bulky and hydrophobic functional group as selective hcvns3 protease inhibitor.
Bioorg. Med. Chem. Lett. 11(2): 91-4.
989. Skelton NJ, Chen YM, Dubree N, Quan C, Jackson DY, Cochran A, Zobel K,
Deshayes K, Baca M, Pisabarro MT, Lowman HB. (2001) Structure-function analysis of
a phage display-derived peptide that binds to insulin-like growth factor binding protein 1.
Biochemistry. 40(29): 8487-98.
990. Su AI, Welsh JB, Sapinoso LM, Kern SG, Dimitrov P, Lapp H, Schultz PG, Powell
SM, Moskaluk CA, Frierson HF, Hampton GM. (2001) Molecular classification of human
carcinomas by use of gene expression signatures. Cancer Res. 61(20): 7388-93.
991. Takayama S, Ostuni E, LeDuc P, Naruse K, Ingber DE, Whitesides GM. (2001)
Laminar flows - subcellular positioning of small molecules. Nature. 411(6841): 1016-.
992. Takayama S, Ostuni E, Qian XP, McDonald JC, Jiang XY, LeDuc P, Wu MH,
Ingber DE, Whitesides GM. (2001) Topographical micropatterning of
poly(dimethylsiloxane) using laminar flows of liquids in capillaries. Adv. Mater. 13(8):
570-+.
993. Tezcan FA, Crane BR, Winkler JR, Gray HB. (2001) Electron tunneling in protein
crystals. Proc. Natl. Acad. Sci. U. S. A. 98(9): 5002-6.
994. Thomas AA, Monk KA, Abraham S, Lee S, Garner CM. (2001) Rearrangement of
methylenecamphor during electrophilic bromination: Remarkably clean access to the
unnatural fenchyl (1,3,3-trimethylbicyclo[2.2.1]heptane) system. Tetrahedron Lett.
42(12): 2261-3.
995. Tian F, Al-Hashimi HM, Craighead JL, Prestegard JH. (2001) Conformational
analysis of a flexible oligosaccharide using residual dipolar couplings. J. Am. Chem.
Soc. 123(3): 485-92.
996. Tian J, Gong XH, Xie ZJ. (2001) Signal-transducing function of na+-k+ -atpase is
essential for ouabain's effect on [ca2+](i) in rat cardiac myocytes. Am. J. Physiol.-Heart
Circul. Physiol. 281(5): H1899-H907.
997. Ting AY, Witte K, Shah K, Kraybill B, Shokat KM, Schultz PG. (2001) Phagedisplay
evolution of tyrosine kinases with altered nucleotide specificity. Biopolymers.
60(3): 220-8.
998. Tremblay MR, Dickerson TJ, Janda KD. (2001) Advances in antibody catalysis of
cycloaddition reactions. Adv. Synth. Catal. 343(6-7): 577-85.
999. Trost BM, Gunzner JL. (2001) Total synthesis of deschlorocallipeltoside a. J. Am.
Chem. Soc. 123(38): 9449-50.
1000. Trost BM, Gunzner JL, Yasukata T. (2001) An unusual regioselectivity in the pdcatalyzed
cross coupling of alkynes. A correction. Tetrahedron Lett. 42(23): 3775-8.
1001. Tsui V, Case DA. (2001) Calculations of the absolute free energies of binding
between rna and metal ions using molecular dynamics simulations and continuum

electrostatics. J. Phys. Chem. B. 105(45): 11314-25.
1002. Vanderwal CD, Vosburg DA, Sorensen EJ. (2001) Intramolecular allenolate
acylations in studies toward a synthesis of fr182877. Org. Lett. 3(26): 4307-10.
1003. Vitart V, Baxter I, Doerner P, Harper JF. (2001) Evidence for a role in growth and
salt resistance of a plasma membrane h+-atpase in the root endodermis. Plant J. 27(3):
191-201.
1004. Wang GK, Ousley A, Darlington TK, Chen DC, Chen YF, Fu WL, Hickman LJ,
Kay SA, Sehgal A. (2001) Regulation of the cycling of timeless (tim) rna. J. Neurobiol.
47(3): 161-75.
1005. Wang HS, Sim MM. (2001) Total solid phase syntheses of the quinazoline
alkaloids: Verrucines a and b and anacine. J. Nat. Prod. 64(12): 1497-501.
1006. Weissman JT, Aridor M, Balch WE. (2001) Purification and properties of rat liver
sec23-sec24 complex. Methods Enzymol. 329: 431-8.
1007. Weissman JT, Plutner H, Balch WE. (2001) The mammalian guanine nucleotide
exchange factor msec12 is essential for activation of the sar1 gtpase directing
endoplasmic reticulum export. Traffic. 2(7): 465-75.
1008. Welsh JB, Sapinoso LM, Su AI, Kern SG, Wang-Rodriguez J, Moskaluk CA,
Frierson HF, Hampton GM. (2001) Analysis of gene expression identifies candidate
markers and pharmacological targets in prostate cancer. Cancer Res. 61(16): 5974-8.
1009. Wentworth P, Jones LH, Wentworth AD, Zhu XY, Larsen NA, Wilson IA, Xu X,
Goddard WA, Janda KD, Eschenmoser A, Lerner RA. (2001) Antibody catalysis of the
oxidation of water. Science. 293(5536): 1806-11.
1010. White JT, Kelly JW. (2001) Support for the multigenic hypothesis of amyloidosis:
The binding stoichiometry of retinol-binding protein, vitamin a, and thyroid hormone
influences transthyretin amyloidogenicity in vitro. Proc. Natl. Acad. Sci. U. S. A. 98(23):
13019-24.
1011. Whitesides GM, Ostuni E, Takayama S, Jiang XY, Ingber DE. (2001) Soft
lithography in biology and biochemistry. Annu. Rev. Biomed. Eng. 3: 335-73.
1012. Wilcox SK, Cavey GS, Pearson JD. (2001) Single ribosomal protein mutations in
antibiotic-resistant bacteria analyzed by mass spectrometry. Antimicrob. Agents
Chemother. 45(11): 3046-55.
1013. Winssinger N, Harris JL, Backes BJ, Schultz PG. (2001) From split-pool libraries
to spatially addressable microarrays and its application to functional proteomic profiling.
Angew. Chem.-Int. Edit. 40(17): 3152-+.
1014. Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA.
(2001) Crystal structure of the murine nk cell-activating receptor nkg2d at 1.95
angstrom. Nat. Immunol. 2(3): 248-54.
1015. Wolkenberg SE, Su AI. (2001) Combinatorial synthesis and discovery of an
antibiotic compound - an experiment suitable for high school and undergraduate
laboratories. J. Chem. Educ. 78(6): 784-5.
1016. Worrall DS, McDunn JE, List B, Reichart D, Hevener A, Gustafson T, Barbas CF,
Lerner RA, Olefsky JM. (2001) Synthesis of an organoinsulin molecule that can be
activated by antibody catalysis. Proc. Natl. Acad. Sci. U. S. A. 98(24): 13514-8.
1017. Wu E, Fernandez J, Fleck SK, Von Seggern DJ, Huang S, Nemerow GR. (2001)

A 50-kda membrane protein mediates sialic acid-independent binding and infection of
conjunctival cells by adenovirus type 37. Virology. 279(1): 78-89.
1018. Wu TYH, Ding S, Gray NS, Schultz PG. (2001) Solid-phase synthesis of 2,3,5trisubstituted
indoles. Org. Lett. 3(24): 3827-30.
1019. Yamashita H, Takenoshita M, Sakurai M, Bruick RK, Henzel WJ, Shillinglaw W,
Arnot D, Uyeda K. (2001) A glucose-responsive transcription factor that regulates
carbohydrate metabolism in the liver. Proc. Natl. Acad. Sci. U. S. A. 98(16): 9116-21.
1020. Yan LZ, Dawson PE. (2001) Design and synthesis of a protein catenane. Angew.
Chem.-Int. Edit. 40(19): 3625-+.
1021. Yan LZ, Dawson PE. (2001) Synthesis of peptides and proteins without cysteine
residues by native chemical ligation combined with desulfurization. J. Am. Chem. Soc.
123(4): 526-33.
1022. Yaron Y, McAdara JK, Lynch M, Hughes E, Gasson JC. (2001) Identification of
novel functional regions important for the activity of hoxb7 in mammalian cells. J.
Immunol. 166(8): 5058-67.
1023. Yin L, Wu L, Wesche H, Arthur CD, White JM, Goeddel DV, Schreiber RD. (2001)
Defective lymphotoxin-beta receptor-induced nf-kappa b transcriptional activity in nikdeficient
mice. Science. 291(5511): 2162-5.
1024. Yu CS, Niikura K, Lin CC, Wong CH. (2001) The thioglycoside and glycosyl
phosphite of 5-azido sialic acid: Excellent donors for the alpha-glycosylation of primary
hydroxy groups. Angew. Chem.-Int. Edit. 40(15): 2900-3.
1025. Yudin AK, Chiang JP, Adolfsson H, Coperet C. (2001) Olefin epoxidation with
bis(trimethylsilyl) peroxide catalyzed by inorganic oxorhenium derivatives. Controlled
release of hydrogen peroxide. J. Org. Chem. 66(13): 4713-8.
1026. Zeitlin SG, Barber CM, Allis CD, Sullivan K. (2001) Differential regulation of cenpa
and histone h3 phosphorylation in g(2)/m. J. Cell Sci. 114(4): 653-61.
1027. Zeitlin SG, Shelby RD, Sullivan KF. (2001) Cenp-a is phosphorylated by aurora b
kinase and plays an unexpected role in completion of cytokinesis. J. Cell Biol. 155(7):
1147-57.
1028. Zeitlin SG, Sullivan KF. (2001) Animal cytokinesis: Breaking up is hard to do.
Curr. Biol. 11(13): R514-R6.
1029. Zhao G, Zhou ZHS. (2001) Vinyl sulfonium as novel proteolytic enzyme inhibitor.
Bioorg. Med. Chem. Lett. 11(17): 2331-5.
1030. Zwick MB, Labrijn AF, Wang M, Spenlehauer C, Saphire EO, Binley JM, Moore
JP, Stiegler G, Katinger H, Burton DR, Parren P. (2001) Broadly neutralizing antibodies
targeted to the membrane-proximal external region of human immunodeficiency virus
type 1 glycoprotein gp41. J. Virol. 75(22): 10892-905.
1031. Abou-Zied OK, Jimenez R, Thompson EHZ, Millar DP, Romesberg FE. (2002)
Solvent-dependent photoinduced tautomerization of 2-(2 '-hydroxyphenyl)benzoxazole.
J. Phys. Chem. A. 106(15): 3665-72.
1032. Adak S, Bilwes AM, Panda K, Hosfield D, Aulak KS, McDonald JF, Tainer JA,
Getzoff ED, Crane BR, Stuehr DJ. (2002) Cloning, expression, and characterization of a
nitric oxide synthase protein from deinococcus radiodurans. Proc. Natl. Acad. Sci. U. S.
A. 99(1): 107-12.

1033. Adam GC, Sorensen EJ, Cravatt BF. (2002) Chemical strategies for functional
proteomics. Mol. Cell. Proteomics. 1(10): 781-90.
1034. Adam GC, Sorensen EJ, Cravatt BF. (2002) Trifunctional chemical probes for the
consolidated detection and identification of enzyme activities from complex proteomes.
Mol. Cell. Proteomics. 1(10): 828-35.
1035. Adam GC, Sorensen EJ, Cravatt BF. (2002) Proteomic profiling of
mechanistically distinct enzyme classes using a common chemotype. Nat. Biotechnol.
20(8): 805-9.
1036. Aebersold R, Cravatt BF. (2002) Proteomics - advances, applications and the
challenges that remain. Trends Biotechnol. 20(12): S1-S2.
1037. Al-Bassam J, Ozer RS, Safer D, Halpain S, Milligan RA. (2002) Map2 and tau
bind longitudinally along the outer ridges of microtubule protofilaments. J. Cell Biol.
157(7): 1187-96.
1038. Anderson JC, Magliery TJ, Schultz PG. (2002) Exploring the limits of codon and
anticodon size. Chem. Biol. 9(2): 237-44.
1039. Balicki D, Beutler E. (2002) Gene therapy of human disease. Medicine
(Baltimore). 81(1): 69-86.
1040. Balicki D, Putnam CD, Scaria PV, Beutler E. (2002) Structure and function
correlation in histone h2a peptide-mediated gene transfer. Proc. Natl. Acad. Sci. U. S.
A. 99(11): 7467-71.
1041. Baran PS, Corey EJ. (2002) A short synthetic route to (+)-austamide, (+)deoxyisoaustamide,
and (+)-hydratoaustamide from a common precursor by a novel
palladium-mediated indole -> dihydroindoloazocine cyclization. J. Am. Chem. Soc.
124(27): 7904-5.
1042. Berg T, Cohen SB, Desharnais J, Sonderegger C, Maslyar DJ, Goldberg J, Boger
DL, Vogt PK. (2002) Small-molecule antagonists of myc/max dimerization inhibit mycinduced
transformation of chicken embryo fibroblasts. Proc. Natl. Acad. Sci. U. S. A.
99(6): 3830-5.
1043. Berger M, Luzzi SD, Henry AA, Romesberg FE. (2002) Stability and selectivity of
unnatural DNA with five-membered-ring nucleobase analogues. J. Am. Chem. Soc.
124(7): 1222-6.
1044. Betz UAK, Fischer R, Kleymann G, Hendrix M, Rubsamen-Waigmann H. (2002)
Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor bay
57-1293. Antimicrob. Agents Chemother. 46(6): 1766-72.
1045. Biros SM, Bridgewater BM, Villeges-Estrada A, Tanski JM, Parkin G. (2002)
Antimony ethylene glycolate and catecholate compounds: Structural characterization of
polyesterification catalysts. Inorg. Chem. 41(15): 4051-7.
1046. Blankenship JW, Balambika R, Dawson PE. (2002) Probing backbone hydrogen
bonds in the hydrophobic core of gcn4. Biochemistry. 41(52): 15676-84.
1047. Bong DTY, Gentric L, Holmes D, Matzger AJ, Scherhag F, Vollhardt KPC. (2002)
Synthesis of bent [4]phenylene (cyclobuta[1,2-alpha : 3,4-b ']bisbiphenylene) and
structure of a bis(trimethylsilyl) derivative: The last [4] phenylene isomer. Chem.
Commun. (3): 278-9.
1048. Boztug K, Carson MJ, Pham-Mitchell N, Asensio VC, DeMartino J, Campbell IL.

(2002) Leukocyte infiltration, but not neurodegeneration, in the cns of transgenic mice
with astrocyte production of the cxc chemokine ligand 10. J. Immunol. 169(3): 1505-15.
1049. Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF. (2002) Structural
adaptations in a membrane enzyme that terminates endocannabinoid signaling.
Science. 298(5599): 1793-6.
1050. Brik A, D'Souza LJ, Keinan E, Grynszpan F, Dawson PE. (2002) Mutants of 4oxalocrotonate
tautomerase catalyze the decarboxylation of oxaloacetate through an
imine mechanism. Chembiochem. 3(9): 845-51.
1051. Brik A, Dawson PE, Keinan E. (2002) The product of the natural reaction
catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant.
Bioorg. Med. Chem. 10(12): 3891-7.
1052. Bruick RK, McKnight SL. (2002) Transcription - oxygen sensing gets a second
wind. Science. 295(5556): 807-8.
1053. Bryan MC, Plettenburg O, Sears P, Rabuka D, Wacowich-Sgarbi S, Wong CH.
(2002) Saccharide display on microtiter plates. Chem. Biol. 9(6): 713-20.
1054. Cannon LM, Butler FN, Wan W, Zhou ZS. (2002) A stereospecific colorimetric
assay for (s,s)-adenosylmethionine quantification based on thiopurine
methyltransferase-catalyzed thiol methylation. Anal. Biochem. 308(2): 358-63.
1055. Ceriani MF, Hogenesch JB, Yanovsky M, Panda S, Straume M, Kay SA. (2002)
Genome-wide expression analysis in drosophila reveals genes controlling circadian
behavior. J. Neurosci. 22(21): 9305-19.
1056. Chang B, Wang X, Hawes NL, Ojakian R, Davisson MT, Lo WK, Gong XH.
(2002) A gja8 (cx50) point mutation causes an alteration of alpha 3 connexin (cx46) in
semi-dominant cataracts of lop10 mice. Hum. Mol. Genet. 11(5): 507-13.
1057. Chang YT, Choi J, Ding S, Prieschl EE, Baumruker T, Lee JM, Chung SK,
Schultz PG. (2002) The synthesis and biological characterization of a ceramide library.
J. Am. Chem. Soc. 124(9): 1856-7.
1058. Chapman E, Ding S, Schultz PG, Wong CH. (2002) A potent and highly selective
sulfotransferase inhibitor. J. Am. Chem. Soc. 124(49): 14524-5.
1059. Chapman E, Wong CH. (2002) A ph sensitive colorometric assay for the highthroughput
screening of enzyme inhibitors and substrates: A case study using kinases.
Bioorg. Med. Chem. 10(3): 551-5.
1060. Chen WQ, Provart NJ, Glazebrook J, Katagiri F, Chang HS, Eulgem T, Mauch F,
Luan S, Zou GZ, Whitham SA, Budworth PR, Tao Y, Xie ZY, Chen X, Lam S, Kreps JA,
Harper JF, Si-Ammour A, Mauch-Mani B, Heinlein M, Kobayashi K, Hohn T, Dangl JL,
Wang X, Zhu T. (2002) Expression profile matrix of arabidopsis transcription factor
genes suggests their putative functions in response to environmental stresses. Plant
Cell. 14(3): 559-74.
1061. Chin JW, Santoro SW, Martin AB, King DS, Wang L, Schultz PG. (2002) Addition
of p-azido-l-phenylaianine to the genetic code of escherichia coli. J. Am. Chem. Soc.
124(31): 9026-7.
1062. Clark TD, Boncheva M, German JM, Weck M, Whitesides GM. (2002) Design of
three-dimensional, millimeter-scale models for molecular folding. J. Am. Chem. Soc.
124(1): 18-9.

1063. Clark TD, Ferrigno R, Tien J, Paul KE, Whitesides GM. (2002) Template-directed
self-assembly of 10-mu m-sized hexagonal plates. J. Am. Chem. Soc. 124(19): 5419-
26.
1064. Collins J, Hyde C, Gray L, Wood B, Blinder RA, Puckett ML, de Christenson
MLR, Koeller KK, Radiology Educ C. (2002) Radiology resident evaluation: A form that
addresses the six competencies of the accreditation council for graduate medical
education. Acad. Radiol. 9(7): 815-6.
1065. Cordova A, Notz W, Zhong GF, Betancort JM, Barbas CF. (2002) A highly
enantioselective amino acid-catalyzed route to functionalized alpha-amino acids. J. Am.
Chem. Soc. 124(9): 1842-3.
1066. Craighead JL, Chang WH, Asturias FJ. (2002) Structure of yeast rna polymerase
ii in solution: Implications for enzyme regulation and interaction with promoter DNA.
Structure. 10(8): 1117-25.
1067. Dann CE, Bruick RK, Deisenhofer J. (2002) Structure of factor-inhibiting hypoxiainducible
factor 1: An asparaginyl hydroxylase involved in the hypoxic response
pathway. Proc. Natl. Acad. Sci. U. S. A. 99(24): 15351-6.
1068. Dawson G, Dawson SA, Marinzi C, Dawson PE. (2002) Anti-tumor promoting
effects of palmitoyl: Protein thioesterase inhibitors against a human neurotumor cell line.
Cancer Lett. 187(1-2): 163-8.
1069. De Souza D, Fabri LJ, Nash A, Hilton DJ, Nicola NA, Baca M. (2002) Sh2
domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase shp-
2 have similar binding specificities. Biochemistry. 41(29): 9229-36.
1070. Decker DJ, Stewart BS, Lehman N. (2002) Major histocompatibility complex
class ii doa sequences from three antarctic seal species verify stabilizing selection on
the do locus. Tissue Antigens. 60(6): 534-8.
1071. Deechongkit S, Kelly JW. (2002) The effect of backbone cyclization on the
thermodynamics of beta-sheet unfolding: Stability optimization of the pinww domain. J.
Am. Chem. Soc. 124(18): 4980-6.
1072. Dehal P, Satou Y, Campbell RK, Chapman J, Degnan B, De Tomaso A,
Davidson B, Di Gregorio A, Gelpke M, Goodstein DM, Harafuji N, Hastings KEM, Ho I,
Hotta K, Huang W, Kawashima T, Lemaire P, Martinez D, Meinertzhagen IA, Necula S,
Nonaka M, Putnam N, Rash S, Saiga H, Satake M, Terry A, Yamada L, Wang HG,
Awazu S, Azumi K, Boore J, Branno M, Chin-bow S, DeSantis R, Doyle S, Francino P,
Keys DN, Haga S, Hayashi H, Hino K, Imai KS, Inaba K, Kano S, Kobayashi K,
Kobayashi M, Lee BI, Makabe KW, Manohar C, Matassi G, Medina M, Mochizuki Y,
Mount S, Morishita T, Miura S, Nakayama A, Nishizaka S, Nomoto H, Ohta F, Oishi K,
Rigoutsos I, Sano M, Sasaki A, Sasakura Y, Shoguchi E, Shin-i T, Spagnuolo A, Stainier
D, Suzuki MM, Tassy O, Takatori N, Tokuoka M, Yagi K, Yoshizaki F, Wada S, Zhang
C, Hyatt PD, Larimer F, Detter C, Doggett N, Glavina T, Hawkins T, Richardson P,
Lucas S, Kohara Y, Levine M, Satoh N, Rokhsar DS. (2002) The draft genome of ciona
intestinalis: Insights into chordate and vertebrate origins. Science. 298(5601): 2157-67.
1073. Demko ZP, Sharpless KB. (2002) A click chemistry approach to tetrazoles by
huisgen 1,3-dipolar cycloaddition: Synthesis of 5-sulfonyl tetrazoles from azides and
sulfonyl cyanides. Angew. Chem.-Int. Edit. 41(12): 2110-3.

1074. Demko ZP, Sharpless KB. (2002) A click chemistry approach to tetrazoles by
huisgen 1,3-dipolar cycloaddition: Synthesis of 5-acyltetrazoles from azides and acyl
cyanides. Angew. Chem.-Int. Edit. 41(12): 2113-6.
1075. Demko ZP, Sharpless KB. (2002) An expedient route to the tetrazole analogues
of alpha-amino acids. Org. Lett. 4(15): 2525-7.
1076. Dickerson TJ, Janda KD. (2002) Aqueous aldol catalysis by a nicotine metabolite.
J. Am. Chem. Soc. 124(13): 3220-1.
1077. Dickerson TJ, Janda KD. (2002) A previously undescribed chemical link between
smoking and metabolic disease. Proc. Natl. Acad. Sci. U. S. A. 99(23): 15084-8.
1078. Dickerson TJ, Reed NN, Janda KD. (2002) Soluble polymers as scaffolds for
recoverable catalysts and reagents. Chem. Rev. 102(10): 3325-43.
1079. Ding S, Gray NS, Ding Q, Wu X, Schultz PG. (2002) Resin-capture and release
strategy toward combinatorial libraries of 2,6,9-substituted purines. J. Comb. Chem.
4(2): 183-6.
1080. Ding S, Gray NS, Wu X, Ding Q, Schultz PG. (2002) A combinatorial scaffold
approach toward kinase-directed heterocycle libraries. J. Am. Chem. Soc. 124(8): 1594-
6.
1081. Dmochowski IJ, Dunn AR, Wilker JJ, Crane BR, Green MT, Dawson JH, Sligar
SG, Winkler JR, Gray HB. (2002) Sensitizer-linked substrates and ligands: Ruthenium
probes of cytochrome p450 structure and mechanism. Methods Enzymol. 357: 120-33.
1082. Dominy BN, Brooks CL. (2002) Identifying native-like protein structures using
physics-based potentials. J. Comput. Chem. 23(1): 147-60.
1083. Dominy BN, Perl D, Schmid FX, Brooks CL. (2002) The effects of ionic strength
on protein stability: The cold shock protein family. J. Mol. Biol. 319(2): 541-54.
1084. Dorrell MI, Aguilar E, Friedlander M. (2002) Retinal vascular development is
mediated by endothelial filopodia, a preexisting astrocytic template and specific rcadherin
adhesion. Invest. Ophthalmol. Vis. Sci. 43(11): 3500-10.
1085. Dupau P, Epple R, Thomas AA, Fokin VV, Sharpless KB. (2002) Osmiumcatalyzed
dihydroxylation of olefins in acidic media: Old process, new tricks. Adv. Synth.
Catal. 344(3-4): 421-33.
1086. Fazio F, Bryan MC, Blixt O, Paulson JC, Wong CH. (2002) Synthesis of sugar
arrays in microtiter plate. J. Am. Chem. Soc. 124(48): 14397-402.
1087. Ferrigno R, Stroock AD, Clark TD, Mayer M, Whitesides GM. (2002)
Membraneless vanadium redox fuel cell using laminar flow. J. Am. Chem. Soc. 124(44):
12930-1.
1088. Frierson HF, Ei-Naggar AK, Welsh JB, Sapinoso LM, Su AI, Cheng J, Saku T,
Moskaluk CA, Hampton GM. (2002) Large scale molecular analysis identifies genes
with altered expression in salivary adenoid cystic carcinoma. Am. J. Pathol. 161(4):
1315-23.
1089. Frosst P, Guan T, Subauste C, Hahn K, Gerace L. (2002) Tpr is localized within
the nuclear basket of the pore complex and has a role in nuclear protein export. J. Cell
Biol. 156(4): 617-30.
1090. Gao CS, Mao SL, Ditzel HJ, Farnaes L, Wirsching P, Lerner RA, Janda KD.
(2002) A cell-penetrating peptide from a novel pvii-pix phage-displayed random peptide

library. Bioorg. Med. Chem. 10(12): 4057-65.
1091. Gao CS, Mao SL, Kaufmann G, Wirsching P, Lerner RA, Janda KD. (2002) A
method for the generation of combinatorial antibody libraries using pix phage display.
Proc. Natl. Acad. Sci. U. S. A. 99(20): 12612-6.
1092. Gielen H, Alonso-Alija C, Hendrix M, Niewbohner U, Schauss D. (2002) A novel
approach to amidines from esters. Tetrahedron Lett. 43(3): 419-21.
1093. Goldberg J, Jin Q, Ambroise Y, Satoh S, Desharnais J, Capps K, Bager DL.
(2002) Erythropoietin mimetics derived from solution phase combinatorial libraries. J.
Am. Chem. Soc. 124(4): 544-55.
1094. Greenhalgh CJ, Metcalf D, Thaus AL, Corbin JE, Uren R, Morgan PO, Fabri LJ,
Zhang JG, Martin HM, Willson TA, Billestrup N, Nicola NA, Baca M, Alexander WS,
Hilton DJ. (2002) Biological evidence that socs-2 can act either as an enhancer or
suppressor of growth hormone signaling. J. Biol. Chem. 277(43): 40181-4.
1095. Gupton SL, Salmon WC, Waterman-Storer CM. (2002) Converging populations of
f-actin promote breakage of associated microtubules to spatially regulate microtubule
turnover in migrating cells. Curr. Biol. 12(22): 1891-9.
1096. Hartgerink JD, Beniash E, Stupp SI. (2002) Peptide-amphiphile nanofibers: A
versatile scaffold for the preparation of self-assembling materials. Proc. Natl. Acad. Sci.
U. S. A. 99(8): 5133-8.
1097. Himo F, Demko ZP, Noodleman L, Sharpless KB. (2002) Mechanisms of
tetrazole formation by addition of azide to nitriles. J. Am. Chem. Soc. 124(41): 12210-6.
1098. Hof F, Craig SL, Nuckolls C, Rebek J. (2002) Molecular encapsulation. Angew.
Chem.-Int. Edit. 41(9): 1488-508.
1099. Hof F, Rebek J. (2002) Molecules within molecules: Recognition through selfassembly.
Proc. Natl. Acad. Sci. U. S. A. 99(8): 4775-7.
1100. Hopfner KP, Putnam CD, Tainer JA. (2002) DNA double-strand break repair from
head to tail. Curr. Opin. Struct. Biol. 12(1): 115-22.
1101. Hotta K, Wilson IA, Hilvert D. (2002) Probing ligand recognition in the
decarboxylase antibody 21d8: Implications for the catalytic mechanism. Biochemistry.
41(3): 772-9.
1102. Huang MD, Weissman JT, Wang CQ, Balch WE, Wilson IA. (2002) Protein
engineering for crystallization of the gtpase sar1 that regulates er vesicle budding. Acta
Crystallogr. Sect. D-Biol. Crystallogr. 58: 700-3.
1103. Huh D, Tung YC, Wei HH, Grotberg JB, Skerlos SJ, Kurabayashi K, Takayama
S. (2002) Use of air-liquid two-phase flow in hydrophobic microfluidic channels for
disposable flow cytometers. Biomed. Microdevices. 4(2): 141-9.
1104. Hyndman ME, Verma S, Rosenfeld RJ, Anderson TJ, Parsons HG. (2002)
Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function.
Am. J. Physiol.-Heart Circul. Physiol. 282(6): H2167-H72.
1105. Irwin M, Gillin JC, Dang J, Weissman J, Phillips E, Ehlers CL. (2002) Sleep
deprivation as a probe of homeostatic sleep regulation in primary alcoholics. Biol.
Psychiatry. 51(8): 632-41.
1106. Jameson J, Ugarte K, Chen N, Yachi P, Fuchs E, Boismenu R, Havran WL.
(2002) A rote for skin gamma delta t cells in wound repair. Science. 296(5568): 747-9.

1107. Jessani N, Liu YS, Humphrey M, Cravatt BF. (2002) Enzyme activity profiles of
the secreted and membrane proteome that depict cancer cell invasiveness. Proc. Natl.
Acad. Sci. U. S. A. 99(16): 10335-40.
1108. Jiang XY, Takayama S, Qian XP, Ostuni E, Wu HK, Bowden N, LeDuc P, Ingber
DE, Whitesides GM. (2002) Controlling mammalian cell spreading and cytoskeletal
arrangement with conveniently fabricated continuous wavy features on
poly(dimethylsiloxane). Langmuir. 18(8): 3273-80.
1109. Johnson DW, Hof F, Iovine PM, Nuckolls C, Rebek J. (2002) Solid-state and
solution studies of a tetrameric capsule and its guests. Angew. Chem.-Int. Edit. 41(20):
3793-6.
1110. Johnson DW, Palmer LC, Hof F, Iovine PM, Rebek J. (2002) New supramolecular
organization for a glycoluril: Chiral hydrogen-bonded ribbons. Chem. Commun. (19):
2228-9.
1111. Karanicolas J, Brooks CL. (2002) The origins of asymmetry in the folding
transition states of protein l and protein g. Protein Sci. 11(10): 2351-61.
1112. Kaul R, Deechongkit S, Kelly JW. (2002) Synthesis of a negatively charged
dibenzofuran-based beta-turn mimetic and its incorporation into the ww miniproteinenhanced
solubility without a loss of thermodynamic stability. J. Am. Chem. Soc.
124(40): 11900-7.
1113. Khor IW, Lin TW, Langedijk JPM, Johnson JE, Manchester M. (2002) Novel
strategy for inhibiting viral entry by use of a cellular receptor-plant virus chimera. J. Virol.
76(9): 4412-9.
1114. Kleymann G, Fischer R, Betz UAK, Hendrix M, Bender W, Schneider U, Handke
G, Eckenberg P, Hewlett G, Pevzner V, Baumeister J, Weber O, Henninger K,
Keldenich J, Jensen A, Kolb J, Bach U, Popp A, Maben J, Frappa I, Haebich D,
Lockhoff O, Rubsamen-Waigmann H. (2002) New helicase-primase inhibitors as drug
candidates for the treatment of herpes simplex disease. Nat. Med. 8(4): 392-8.
1115. Klok HA, Hwang JJ, Hartgerink JD, Stupp SI. (2002) Self-assembling
biomaterials: L-lysine-dendron-substituted cholesteryl-(l-lactic acid)(n)over-bar.
Macromolecules. 35(16): 6101-11.
1116. Kohli RM, Walsh CT, Burkart MD. (2002) Biomimetic synthesis and optimization
of cyclic peptide antibiotics. Nature. 418(6898): 658-61.
1117. Kolodner RD, Putnam CD, Myung K. (2002) Maintenance of genome stability in
saccharomyces cerevisiae. Science. 297(5581): 552-7.
1118. Krenitsky PJ, Boger DL. (2002) Preparation of the 14-membered l,lcycloisodityrosine
subunit of rp 66453. Tetrahedron Lett. 43(3): 407-10.
1119. Lam WC, Thompson EHZ, Potapova O, Sun XJC, Joyce CM, Millar DP. (2002) 3
'-5 ' exonuclease of klenow fragment: Role of amino acid residues within the singlestranded
DNA binding region in exonucleolysis and duplex DNA melting. Biochemistry.
41(12): 3943-51.
1120. Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK. (2002) Fih-
1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of
hypoxia-inducible factor. Genes Dev. 16(12): 1466-71.
1121. Larsen NA, Heine A, de Prada P, Redwan ER, Yeates TO, Landry DW, Wilson

IA. (2002) Structure determination of a cocaine hydrolytic antibody from a
pseudomerohedrally twinned crystal. Acta Crystallogr. Sect. D-Biol. Crystallogr. 58:
2055-9.
1122. Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC,
Wilson IA. (2002) Crystal structure of a bacterial cocaine esterase. Nat. Struct. Biol.
9(1): 17-21.
1123. Lee KJ, Mao SL, Sun CZ, Gao CS, Blixt O, Arrues S, Hom LG, Kaufmann GF,
Hoffman TZ, Coyle AR, Paulson J, Felding-Habermann B, Janda KD. (2002) Phagedisplay
selection of a human single-chain fv antibody highly specific for melanoma and
breast cancer cells using a chemoenzymatically synthesized g(m3)-carbohydrate
antigen. J. Am. Chem. Soc. 124(42): 12439-46.
1124. Lesley SA, Graziano J, Cho CY, Knuth MW, Klock HE. (2002) Gene expression
response to misfolded protein as a screen for soluble recombinant protein. Protein Eng.
15(2): 153-60.
1125. Lewis WG, Green LG, Grynszpan F, Radic Z, Carlier PR, Taylor P, Finn MG,
Sharpless KB. (2002) Click chemistry in situ: Acetylcholinesterase as a reaction vessel
for the selective assembly of a femtomolar inhibitor from an array of building blocks.
Angew. Chem.-Int. Edit. 41(6): 1053-+.
1126. Lewy DS, Gauss CM, Soenen DR, Boger DL. (2002) Fostriecin: Chemistry and
biology. Curr. Med. Chem. 9(22): 2005-32.
1127. Lichtman AH, Hawkins EG, Griffin G, Cravatt BF. (2002) Pharmacological activity
of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo.
J. Pharmacol. Exp. Ther. 302(1): 73-9.
1128. Lin CH, Huang HM, Hsieh M, Pollard KM, Li C. (2002) Arginine methylation of
recombinant murine fibrillarin by protein arginine methyltransferase. J. Protein Chem.
21(7): 447-53.
1129. Littlefield R, Fowler VM. (2002) Measurement of thin filament lengths by
distributed deconvolution analysis of fluorescence images. Biophys. J. 82(5): 2548-64.
1130. Littlefield R, Fowler VM. (2002) A minor actin catastrophe. Nat. Cell Biol. 4(9):
E209-E11.
1131. Liu CS, Wang ZH, Chen GQ, Li YM, Wu ED, Li DJ, Li B, Dou WB, Dong ZW.
(2002) A dab transmitter prototype with high flexibility and low cost. IEEE Trans.
Broadcast. 48(3): 173-8.
1132. Liu J, Wong CH. (2002) Selectfluor (tm)-mediated allylstannation of aldehydes
and imines. Tetrahedron Lett. 43(21): 3915-7.
1133. Liu JJ, DeSantis G, Wong CH. (2002) Structure-based rationalization of aldolasecatalyzed
asymmetric synthesis. Can. J. Chem.-Rev. Can. Chim. 80(6): 643-5.
1134. Liu JJ, Huang CY, Wong CH. (2002) An efficient method for the preparation of 2hydroxy-
and 2-aminoglycals from glycosyl sulfoxides. Tetrahedron Lett. 43(18): 3447-8.
1135. Liu JJ, Wong CH. (2002) Aldolase-catalyzed asymmetric synthesis of novel
pyranose synthons as a new entry to heterocycles and epothilones. Angew. Chem.-Int.
Edit. 41(8): 1404-7.
1136. Liu JJ, Wong CH. (2002) An efficient method for the cleavage of pmethoxybenzylidene
(pmp), tetrahydropyranyl (thp) and 1,3-dithiane protecting groups

y selectfluor (tm). Tetrahedron Lett. 43(22): 4037-9.
1137. MacBeath G. (2002) Protein microarrays and proteomics. Nature Genet. 32: 526-
32.
1138. Marshall CG, Burkart MD, Meray RK, Walsh CT. (2002) Carrier protein
recognition in siderophore-producing nonribosomal peptide synthetases. Biochemistry.
41(26): 8429-37.
1139. Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ,
Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP,
Benkovic SJ, Boger DL. (2002) 10-formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic
acid (10-formyl-ddacthf): A potent cytotoxic agent acting by selective inhibition of human
gar tfase and the de novo purine biosynthetic pathway. Bioorg. Med. Chem. 10(8):
2739-49.
1140. Marx PF, Dawson PE, Bouma BN, Meijers JCM. (2002) Plasmin-mediated
activation and inactivation of thrombin-activatable fibrinolysis inhibitor. Biochemistry.
41(21): 6688-96.
1141. McAtee JJ, Castle SL, Jin Q, Boger DL. (2002) Synthesis and evaluation of
vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3
asparagine. Bioorg. Med. Chem. Lett. 12(9): 1319-22.
1142. McCammon MG, Scott DJ, Keetch CA, Greene LH, Purkey HE, Petrassi HM,
Kelly JW, Robinson CV. (2002) Screening transthyretin amyloid fibril inhibitors:
Characterization of novel multiprotein, multiligand complexes by mass spectrometry.
Structure. 10(6): 851-63.
1143. McGinness KE, Joyce GF. (2002) Rna-catalyzed rna ligation on an external rna
template. Chem. Biol. 9(3): 297-307.
1144. McGinness KE, Joyce GF. (2002) Substitution of ribonucleotides in the t7 rna
polymerase promoter element. J. Biol. Chem. 277(4): 2987-91.
1145. McGinness KE, Wright MC, Joyce GF. (2002) Continuous in vitro evolution of a
ribozyme that catalyzes three successive nucleotidyl addition reactions. Chem. Biol.
9(5): 585-96.
1146. Merkel AB, Temple GK, Burkart MD, Losey HC, Beis K, Walsh CT, Naismith JH.
(2002) Purification, crystallization and preliminary structural studies of dtdp-4-keto-6deoxy-glucose-5-epimerase
(evad) from amycolatopsis orientalis, the fourth enzyme in
the dtdp-l-epivancosamine biosynthetic pathway. Acta Crystallogr. Sect. D-Biol.
Crystallogr. 58: 1226-8.
1147. Mitchell ML, Lee LV, Wong CH. (2002) Synthesis and evaluation of sixmembered
gdp-iminocyclitol. Tetrahedron Lett. 43(32): 5691-3.
1148. Mitchell ML, Tian F, Lee LV, Wong CH. (2002) Synthesis and evaluation of
transition-state analogue inhibitors of alpha-1,3-fucosyltransferase. Angew. Chem.-Int.
Edit. 41(16): 3041-4.
1149. Moss JA, Dickerson TJ, Janda KD. (2002) Solid phase peptide synthesis on
jandajel (tm) resin. Tetrahedron Lett. 43(1): 37-40.
1150. Musah RA, Jensen GM, Bunte SW, Rosenfeld RJ, Goodin DB. (2002) Artificial
protein cavities as specific ligand-binding templates: Characterization of an engineered
heterocyclic cation-binding site that preserves the evolved specificity of the parent

protein. J. Mol. Biol. 315(4): 845-57.
1151. Nangle LA, Lagardt VD, Dodring V, Schimmel P. (2002) Genetic code ambiguity -
cell viability related to severity of editing defects in mutant trna synthetases. J. Biol.
Chem. 277(48): 45729-33.
1152. Nelson MR, Thulin E, Fagan PA, Forsen S, Chazin WJ. (2002) The ef-hand
domain: A globally cooperative structural unit. Protein Sci. 11(2): 198-205.
1153. Newman PA, Harris NRP, Adriani A, Amanatidis GT, Anderson JG, Braathen
GO, Brune WH, Carslaw KS, Craig MS, DeCola PL, Guirlet M, Hipskind RS, Kurylo MJ,
Kullmann H, Larsen N, Megie GJ, Pommereau JP, Poole LR, Schoeberl MR, Stroh F,
Toon OB, Trepte CR, Van Roozendael M. (2002) An overview of the solve/theseo 2000
campaign. J. Geophys. Res.-Atmos. 107(D20): 26.
1154. Nicholas GM, Eckman LL, Ray S, Hughes RO, Pfefferkorn JA, Barluenga S,
Nicolaou KC, Bewley CA. (2002) Bromotyrosine-derived natural and synthetic products
as inhibitors of mycothiol-s-conjugate amidase. Bioorg. Med. Chem. Lett. 12(17): 2487-
90.
1155. Nicolaou KC, Baran PS. (2002) The cp molecule labyrinth: A paradigm of how
endeavors in total synthesis lead to discoveries and inventions in organic synthesis.
Angew. Chem.-Int. Edit. 41(15): 2679-720.
1156. Nicolaou KC, Baran PS, Zhong YL, Barluenga S, Hunt KW, Kranich R, Vega JA.
(2002) Iodine(v) reagents in organic synthesis. Part 3. New routes to heterocyclic
compounds via o-iodoxybenzoic acid-mediated cyclizations: Generality, scope, and
mechanism. J. Am. Chem. Soc. 124(10): 2233-44.
1157. Nicolaou KC, Baran PS, Zhong YL, Fong KC, Choi KS. (2002) Total synthesis of
the cp-molecules (cp-263,114 and cp-225,917, phomoidrides b and a). 2. Model studies
for the construction of key structural elements and first-generation strategy. J. Am.
Chem. Soc. 124(10): 2190-201.
1158. Nicolaou KC, Baran PS, Zhong YL, Sugita K. (2002) Iodine(v) reagents in organic
synthesis. Part 1. Synthesis of polycyclic heterocycles via dess-martin periodinanemediated
cascade cyclization: Generality, scope, and mechanism of the reaction. J. Am.
Chem. Soc. 124(10): 2212-20.
1159. Nicolaou KC, Bella M, Chen DYK, Huang XH, Ling TT, Snyder SA. (2002) Total
synthesis of diazonamide a. Angew. Chem.-Int. Edit. 41(18): 3495-9.
1160. Nicolaou KC, Boddy CNC. (2002) Atropselective macrocyclization of diaryl ether
ring systems: Application to the synthesis of vancomycin model systems. J. Am. Chem.
Soc. 124(35): 10451-5.
1161. Nicolaou KC, Follmann M, Roecker AJ, Hunt KW. (2002) Model studies towards
azadirachtin: Part 1. Construction of the crowded c8-c14 bond by radical chemistry.
Angew. Chem.-Int. Edit. 41(12): 2103-6.
1162. Nicolaou KC, Gray DLF, Montagnon T, Harrison ST. (2002) Oxidation of silyl enol
ethers by using ibx and ibx center dot n-oxide complexes: A mild and selective reaction
for the synthesis of enones. Angew. Chem.-Int. Edit. 41(6): 996-+.
1163. Nicolaou KC, Huang XH, Snyder SA, Rao PB, Bella M, Reddy MV. (2002) A
novel regio- and stereoselective synthesis of sulfamidates from 1,2-diols using burgess
and related reagents: A facile entry into beta-amino alcohols. Angew. Chem.-Int. Edit.

41(5): 834-+.
1164. Nicolaou KC, Jennings MP, Dagneau P. (2002) An expedient entry into the fused
polycyclic skeleton of vannusal a. Chem. Commun. (21): 2480-1.
1165. Nicolaou KC, Jung J, Yoon WH, Fong KC, Choi HS, He Y, Zhong YL, Baran PS.
(2002) Total synthesis of the cp-molecules (cp-263,114 and cp-225,917, phomoidrides
b and a). 1. Racemic and asymmetric synthesis of bicyclo[4.3.1] key building blocks. J.
Am. Chem. Soc. 124(10): 2183-9.
1166. Nicolaou KC, Longbottom DA, Snyder SA, Nalbanadian AZ, Huang XH. (2002) A
new method for the synthesis of nonsymmetrical sulfamides using burgess-type
reagents. Angew. Chem.-Int. Edit. 41(20): 3866-70.
1167. Nicolaou KC, Montagnon T, Baran PS. (2002) Hio3 and i2o5: Mild and selective
alternative reagents to ibx for the dehydrogenation of aldehydes and ketones. Angew.
Chem.-Int. Edit. 41(8): 1386-9.
1168. Nicolaou KC, Montagnon T, Baran PS. (2002) Modulation of the reactivity profile
of ibx by ligand complexation: Ambient temperature dehydrogenation of aldehydes and
ketones to alpha,beta-unsaturated carbonyl compounds. Angew. Chem.-Int. Edit. 41(6):
993-+.
1169. Nicolaou KC, Montagnon T, Baran PS, Zhong YL. (2002) Iodine(v) reagents in
organic synthesis. Part 4. O-iodoxybenzoic acid as a chemospecific tool for single
electron transfer-based oxidation processes. J. Am. Chem. Soc. 124(10): 2245-58.
1170. Nicolaou KC, Montagnon T, Ulven T, Baran PS, Zhong YL, Sarabia F. (2002)
Novel chemistry of alpha-tosyloxy ketones: Applications to the solution- and solid-phase
synthesis of privileged heterocycle and enediyne libraries. J. Am. Chem. Soc. 124(20):
5718-28.
1171. Nicolaou KC, Nevalainen M, Safina BS, Zak M, Bulat S. (2002) A biomimetically
inspired synthesis of the dehydropiperidine domain of thiostrepton. Angew. Chem.-Int.
Edit. 41(11): 1941-+.
1172. Nicolaou KC, Ritzen A, Namoto K, Buey RM, Diaz JF, Andreu JM, Wartmann M,
Altmann KH, O'Brate A, Giannakakou P. (2002) Chemical synthesis and biological
evaluation of novel epothilone b and trans-12,13-cyclopropyl epothilone b analogues.
Tetrahedron. 58(32): 6413-32.
1173. Nicolaou KC, Roecker AJ, Follmann M, Baati R. (2002) Model studies towards
azadirachtin: Part 2. Construction of the crowded c8-c14 bond by transition metal
chemistry. Angew. Chem.-Int. Edit. 41(12): 2107-10.
1174. Nicolaou KC, Safina BS, Funke C, Zak M, Zecri FJ. (2002) Stereocontrolled
synthesis of the quinaldic acid macrocyclic system of thiostrepton. Angew. Chem.-Int.
Edit. 41(11): 1937-+.
1175. Nicolaou KC, Snyder SA, Montagnon T, Vassilikogiannakis G. (2002) The dielsalder
reaction in total synthesis. Angew. Chem.-Int. Edit. 41(10): 1668-98.
1176. Nicolaou KC, Sugita K, Baran PS, Zhong YL. (2002) Iodine(v) reagents in organic
synthesis. Part 2. Access to complex molecular architectures via dess-martin
periodinane-generated o-imidoquinones. J. Am. Chem. Soc. 124(10): 2221-32.
1177. Nicolaou KC, Zhong YL, Baran PS, Jung J, Choi HS, Yoon WH. (2002) Total
synthesis of the cp-molecules (cp-263,114 and cp-225,917, phomoidrides b and a). 3.

Completion and synthesis of advanced analogues. J. Am. Chem. Soc. 124(10): 2202-
11.
1178. Nordin BE, Schimmel P. (2002) Plasticity of recognition of the 3 '-end of
mischarged trna by class i aminoacyl-trna synthetases. J. Biol. Chem. 277(23): 20510-
7.
1179. Nyffeler PT, Liang CH, Koeller KM, Wong CH. (2002) The chemistry of amineazide
interconversion: Catalytic diazotransfer and regioselective azide reduction. J. Am.
Chem. Soc. 124(36): 10773-8.
1180. Offer J, Boddy CNC, Dawson PE. (2002) Extending synthetic access to proteins
with a removable acyl transfer auxiliary. J. Am. Chem. Soc. 124(17): 4642-6.
1181. Otani A, Slike BM, Dorrell MI, Hood J, Kinder K, Ewalt KL, Cheresh D, Schimmel
P, Friedlander M. (2002) A fragment of human trprs as a potent antagonist of ocular
angiogenesis. Proc. Natl. Acad. Sci. U. S. A. 99(1): 178-83.
1182. Oza VB, Smith C, Raman P, Koepf EK, Lashuel HA, Petrassi HM, Chiang KP,
Powers ET, Sachettinni J, Kelly JW. (2002) Synthesis, structure, and activity of
diclofenac analogues as transthyretin amyloid fibril formation inhibitors. J. Med. Chem.
45(2): 321-32.
1183. Panda K, Rosenfeld RJ, Ghosh S, Meade AL, Getzoff ED, Stuehr DJ. (2002)
Distinct dimer interaction and regulation in nitric-oxide synthase types i, ii, and iii. J. Biol.
Chem. 277(34): 31020-30.
1184. Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay
SA, Takahashi JS, Hogenesch JB. (2002) Coordinated transcription of key pathways in
the mouse by the circadian clock. Cell. 109(3): 307-20.
1185. Panda S, Hogenesch JB, Kay SA. (2002) Circadian rhythms from flies to human.
Nature. 417(6886): 329-35.
1186. Panda S, Poirier GG, Kay SA. (2002) Tej defines a role for poly(adp-ribosyl)ation
in establishing period length of the arabidopsis circadian oscillator. Dev. Cell. 3(1): 51-
61.
1187. Panda S, Sato TK, Castrucci AM, Rollag MD, DeGrip WJ, Hogenesch JB,
Provencio I, Kay SA. (2002) Melanopsin (opn4) requirement for normal light-induced
circadian phase shifting. Science. 298(5601): 2213-6.
1188. Pant K, Bilwes AM, Adak S, Stuehr DJ, Crane BR. (2002) Structure of a nitric
oxide synthase heme protein from bacillus subtilis. Biochemistry. 41(37): 11071-9.
1189. Parikh PB, Kim YS, Chang YT. (2002) Single resin bead kinetics using real time
fluorescence measurements. Bull. Korean Chem. Soc. 23(11): 1509-10.
1190. Petrich BG, Gong XH, Lerner DL, Wang X, Brown JH, Saffitz JE, Wang YB.
(2002) C-jun n-terminal kinase activation mediates downregulation of connexin43 in
cardiomyocytes. Circ.Res. 91(7): 640-7.
1191. Phoon CW, Sim MM. (2002) The scope and future of traceless synthesis in
organic chemistry. Curr. Org. Chem. 6(11): 937-64.
1192. Phoon CW, Sim MM. (2002) Solid-phase syntheses of 1,2,4-trisubstituted urazole
and thiourazole derivatives. J. Comb. Chem. 4(5): 491-5.
1193. Purse BW, Shivanyuk A, Rebek J. (2002) Resorcin[6]arene as a building block
for tubular crystalline state architectures. Chem. Commun. (22): 2612-3.

1194. Ritter MR, Dorrell MI, Edmonds J, Friedlander SF, Friedlander M. (2002) Insulinlike
growth factor 2 and potential regulators of hemangioma growth and involution
identified by large-scale expression analysis. Proc. Natl. Acad. Sci. U. S. A. 99(11):
7455-60.
1195. Rong P, Wang X, Niesman I, Wu Y, Benedetti LE, Dunia I, Levy E, Gong XH.
(2002) Disruption of gja8 (alpha 8 connexin) in mice leads to microphthalmia associated
with retardation of lens growth and lens fiber maturation. Development. 129(1): 167-74.
1196. Rosenfeld RJ, Garcin ED, Panda K, Andersson G, Aberg A, Wallace AV, Morris
GM, Olson AJ, Stuehr DJ, Tainer JA, Getzoff ED. (2002) Conformational changes in
nitric oxide synthases induced by chlorzoxazone and nitroindazoles: Crystallographic
and computational analyses of inhibitor potency. Biochemistry. 41(47): 13915-25.
1197. Rosenfeld RJ, Hays AMA, Musah RA, Goodin DB. (2002) Excision of a proposed
electron transfer pathway in cytochrome c peroxidase and its replacement by a ligandbinding
channel. Protein Sci. 11(5): 1251-9.
1198. Rouiller I, DeLaBarre B, May AP, Weis WI, Brunger AT, Milligan RA, Wilson-
Kubalek EM. (2002) Conformational changes of the multifunction p97 aaa atpase during
its atpase cycle. Nat. Struct. Biol. 9(12): 950-7.
1199. Sadamoto R, Niikura K, Sears PS, Liu HT, Wong CH, Suksomcheep A, Tomita F,
Monde K, Nishimura SI. (2002) Cell-wall engineering of living bacteria. J. Am. Chem.
Soc. 124(31): 9018-9.
1200. Sanchez-Ouesada J, Isler MP, Ghadiri MR. (2002) Modulating ion channel
properties of transmembrane peptide nanotubes through heteromeric supramolecular
assemblies. J. Am. Chem. Soc. 124(34): 10004-5.
1201. Santoro SW, Schultz PG. (2002) Directed evolution of the site specificity of cre
recombinase. Proc. Natl. Acad. Sci. U. S. A. 99(7): 4185-90.
1202. Santoro SW, Wang L, Herberich B, King DS, Schultz PG. (2002) An efficient
system for the evolution of aminoacyl-trna synthetase specificity. Nat. Biotechnol.
20(10): 1044-8.
1203. Saphire ACS, Bobardt MD, Gallay PA. (2002) Cyclophilin a plays distinct roles in
human immunodeficiency virus type 1 entry and postentry events, as revealed by
spinoculation. J. Virol. 76(9): 4671-7.
1204. Saphire ACS, Bobardt MD, Gallay PA. (2002) Trans-complementation rescue of
cyclophilin a-deficient viruses reveals that the requirement for cyclophilin a in human
immunodeficiency virus type 1 replication is independent of its isomerase activity. J.
Virol. 76(5): 2255-62.
1205. Saphire EO, Stanfield RL, Crispin MDM, Parren P, Rudd PM, Dwek RA, Burton
DR, Wilson IA. (2002) Contrasting igg structures reveal extreme asymmetry and
flexibility. J. Mol. Biol. 319(1): 9-18.
1206. Sawano A, Takayama S, Matsuda M, Miyawaki A. (2002) Lateral propagation of
egf signaling after local stimulation is dependent on receptor density. Dev. Cell. 3(2):
245-57.
1207. Sawkar AR, Cheng WC, Beutler E, Wong CH, Balch WE, Kelly JW. (2002)
Chemical chaperones increase the cellular activity of n370s beta-glucosidase: A
therapeutic strategy for gaucher disease. Proc. Natl. Acad. Sci. U. S. A. 99(24): 15428-

33.
1208. Scanlan CN, Pantophlet R, Wormald MR, Saphire EO, Stanfield R, Wilson IA,
Katinger H, Dwek RA, Rudd PM, Burton DR. (2002) The broadly neutralizing anti-human
immunodeficiency virus type 1 antibody 2g12 recognizes a cluster of alpha 1 -> 2
mannose residues on the outer face of gp120. J. Virol. 76(14): 7306-21.
1209. Sheinerman FB, Honig B. (2002) On the role of electrostatic interactions in the
design of protein-protein interfaces. J. Mol. Biol. 318(1): 161-77.
1210. Shipe WD, Sorensen EJ. (2002) A convergent synthesis of the tricyclic
architecture of the guanacastepenes featuring a selective ring fragmentation. Org. Lett.
4(12): 2063-6.
1211. Sim MM, Ng SB, Buss AD, Crasta SC, Goh KL, Lee SK. (2002) Benzylidene
rhodanines as novel inhibitors of udp-n-acetylmuramate/l-alanine ligase. Bioorg. Med.
Chem. Lett. 12(4): 697-9.
1212. Sipe JC, Chiang K, Gerber AL, Beutler E, Cravatt BF. (2002) A missense
mutation in human fatty acid amide hydrolase associated with problem drug use. Proc.
Natl. Acad. Sci. U. S. A. 99(12): 8394-9.
1213. Song YC, Wang J, Teng SF, Kesuma D, Deng Y, Duan JN, Wang JH, Qi RZ, Sim
MM. (2002) Beta-carbolines as specific inhibitors of cyclin-dependent kinases. Bioorg.
Med. Chem. Lett. 12(7): 1129-32.
1214. Su AI, Cooke MP, Ching KA, Hakak Y, Walker JR, Wiltshire T, Orth AP, Vega
RG, Sapinoso LM, Moqrich A, Patapoutian A, Hampton GM, Schultz PG, Hogenesch
JB. (2002) Large-scale analysis of the human and mouse transcriptomes. Proc. Natl.
Acad. Sci. U. S. A. 99(7): 4465-70.
1215. Su AI, Guidotti LG, Pezacki JP, Chisari FV, Schultz PG. (2002) Gene expression
during the priming phase of liver regeneration after partial hepatectomy in mice. Proc.
Natl. Acad. Sci. U. S. A. 99(17): 11181-6.
1216. Su AI, Pezacki JP, Wodicka L, Brideau AD, Supekova L, Thimme R, Wieland S,
Bukh J, Purcell RH, Schultz PG, Chisari FV. (2002) Genomic analysis of the host
response to hepatitis c virus infection. Proc. Natl. Acad. Sci. U. S. A. 99(24): 15669-74.
1217. Supekova L, Pezacki JP, Su AI, Loweth CJ, Riedl R, Geierstanger B, Schultz PG,
Wemmer DE. (2002) Genomic effects of polyamide/DNA interactions on mrna
expression. Chem. Biol. 9(7): 821-7.
1218. Tan L, Chen CY, Chen WR, Frey L, King AO, Tillyer RD, Xu F, Zhao D,
Grabowski EJJ, Reider PJ, O'Shea P, Dagneau P, Wang X. (2002) Practical
enantioselective synthesis of a cox-2 specific inhibitor. Tetrahedron. 58(37): 7403-10.
1219. Tezcan FA, Findley WM, Crane BR, Ross SA, Lyubovitsky JG, Gray HB, Winkler
JR. (2002) Using deeply trapped intermediates to map the cytochrome c folding
landscape. Proc. Natl. Acad. Sci. U. S. A. 99(13): 8626-30.
1220. Thomas MG, Burkart MD, Walsh CT. (2002) Conversion of l-proline to pyrrolyl-2carboxyl-s-pcp
during undecylprodigiosin and pyoluteorin biosynthesis. Chem. Biol.
9(2): 171-84.
1221. Thompson EHZ, Bailey MF, van der Schans EJC, Joyce CM, Millar DP. (2002)
Determinants of DNA mismatch recognition within the polymerase domain of the klenow
fragment. Biochemistry. 41(3): 713-22.

1222. Trost BM, Dirat O, Gunzner JL. (2002) Callipeltoside a: Assignment of absolute
and relative configuration by total synthesis. Angew. Chem.-Int. Edit. 41(5): 841-+.
1223. Trost BM, Gunzner JL, Dirat O, Rhee YH. (2002) Callipeltoside a: Total
synthesis, assignment of the absolute and relative configuration, and evaluation of
synthetic analogues. J. Am. Chem. Soc. 124(35): 10396-415.
1224. Tsao TS, Murrey HE, Hug C, Lee DH, Lodish HF. (2002) Oligomerization statedependent
activation of nf-kappa b signaling pathway by adipocyte complement-related
protein of 30 kda (acrp30). J. Biol. Chem. 277(33): 29359-62.
1225. Turner JM, Larsen NA, Basran A, Barbas CF, Bruce NC, Wilson IA, Lerner RA.
(2002) Biochemical characterization and structural analysis of a highly proficient cocaine
esterase. Biochemistry. 41(41): 12297-307.
1226. Vosburg DA, Vanderwal CD, Sorensen EJ. (2002) A synthesis of (+)-fr182877,
featuring tandem transannular diels-alder reactions inspired by a postulated biogenesis.
J. Am. Chem. Soc. 124(17): 4552-3.
1227. Waleh NS, Cravatt BF, Apte-Deshpande A, Terao A, Kilduff TS. (2002)
Transcriptional regulation of the mouse fatty acid amide hydrolase gene. Gene. 291(1-
2): 203-10.
1228. Walsh DP, Pang C, Parikh PB, Kim YS, Chang YT. (2002) Comparative resin
kinetics using in situ fluorescence measurements. J. Comb. Chem. 4(3): 204-8.
1229. Wang HS, Yeo SL, Xu J, Xu XL, He H, Ronca F, Ting AE, Wang Y, Yu VC, Sim
MM. (2002) Isolation of streptonigrin and its novel derivative from micromonospora as
inducing agents of p53-dependent cell apoptosis. J. Nat. Prod. 65(5): 721-4.
1230. Wang Q, Kaltgrad E, Lin TW, Johnson JE, Finn MG. (2002) Natural
supramolecular building blocks: Wild-type cowpea mosaic virus. Chem. Biol. 9(7): 805-
11.
1231. Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH. (2002) Studies on the
immuno-modulating and antitumor activities of ganoderma lucidum (reishi)
polysaccharides: Functional and proteomic analyses of a fucose-containing glycoprotein
fraction responsible for the activities. Bioorg. Med. Chem. 10(4): 1057-62.
1232. Wentworth P, McDunn JE, Wentworth AD, Takeuchi C, Nieva J, Jones T,
Bautista C, Ruedi JM, Gutierrez A, Janda KD, Babior BM, Eschenmoser A, Lerner RA.
(2002) Evidence for antibody-catalyzed ozone formation in bacterial killing and
inflammation. Science. 298(5601): 2195-9.
1233. Wilkie GD, Elliott GI, Blagg BSJ, Wolkenberg SE, Soenen DR, Miller MM, Pollack
S, Boger DL. (2002) Intramolecular diels-alder and tandem intramolecular dielsalder/1,3-dipolar
cycloaddition reactions of 1,3,4-oxadiazoles. J. Am. Chem. Soc.
124(38): 11292-4.
1234. Winssinger N, Ficarro S, Schultz PG, Harris JL. (2002) Profiling protein function
with small molecule microarrays. Proc. Natl. Acad. Sci. U. S. A. 99(17): 11139-44.
1235. Wolan DW, Greasley SE, Beardsley GP, Wilson IA. (2002) Structural insights into
the avian aicar transformylase mechanism. Biochemistry. 41(52): 15505-13.
1236. Wolkenberg SE, Boger DL. (2002) Mechanisms of in situ activation for DNAtargeting
antitumor agents. Chem. Rev. 102(7): 2477-95.
1237. Wolkenberg SE, Boger DL. (2002) Total synthesis of anhydrolycorinone utilizing

sequential intramolecular diels-alder reactions of a 1,3,4-oxadiazole. J. Org. Chem.
67(21): 7361-4.
1238. Wrasidlo W, Gaedicke G, Guy RK, Renaud J, Pitsinos E, Nicolaou KC, Reisfeld
RA, Lode HN. (2002) A novel 2 '-(n-methylpyridinium acetate) prodrug of paclitaxel
induces superior antitumor responses in preclinical cancer models. Bioconjugate Chem.
13(5): 1093-9.
1239. Wu BG, Yang J, He Y, Swayze EE. (2002) Reexamination of neomycin b
degradation: Efficient preparation of its cd and d rings as protected glycosyl donors.
Org. Lett. 4(20): 3455-8.
1240. Wu TYH, Schultz PG. (2002) A versatile linkage strategy for solid-phase
synthesis of n,n-dimethyltryptamines and beta-carbolines. Org. Lett. 4(23): 4033-6.
1241. Wu X, Ding S, Ding Q, Gray NS, Schultz PG. (2002) A small molecule with
osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J. Am.
Chem. Soc. 124(49): 14520-1.
1242. Xia B, Tsui V, Case DA, Dyson HJ, Wright PE. (2002) Comparison of protein
solution structures refined by molecular dynamics simulation in vacuum, with a
generalized born model, and with explicit water. J. Biomol. NMR. 22(4): 317-31.
1243. Yegneswaran S, Fernandez JA, Griffin JH, Dawson PE. (2002) Factor va
increases the affinity of factor xa for prothrombin: A binding study using a novel
photoactivable thiol-specific fluorescent probe. Chem. Biol. 9(4): 485-94.
1244. Yin YH, Cheong H, Friedrichsen D, Zhao YD, Hu JP, Mora-Garcia S, Chory J.
(2002) A crucial role for the putative arabidopsis topoisomerase vi in plant growth and
development. Proc. Natl. Acad. Sci. U. S. A. 99(15): 10191-6.
1245. Yin YH, Wang ZY, Mora-Garcia S, Li JM, Yoshida S, Asami T, Chory J. (2002)
Bes1 accumulates in the nucleus in response to brassinosteroids to regulate gene
expression and promote stem elongation. Cell. 109(2): 181-91.
1246. Yin YH, Wu DY, Chory J. (2002) Plant receptor kinases: Systemin receptor
identified. Proc. Natl. Acad. Sci. U. S. A. 99(14): 9090-2.
1247. Yokobayashi Y, Weiss R, Arnold FH. (2002) Directed evolution of a genetic
circuit. Proc. Natl. Acad. Sci. U. S. A. 99(26): 16587-91.
1248. Yu CZ, Henry AA, Romesberg FE, Schultz PG. (2002) Polymerase recognition of
unnatural base pairs. Angew. Chem.-Int. Edit. 41(20): 3841-4.
1249. Yue EW, Higley CA, DiMeo SV, Carini DJ, Nugiel DA, Benware C, Benfield PA,
Burton CR, Cox S, Grafstrom RH, Sharp DM, Sisk LM, Boylan JF, Muckelbauer JK,
Smallwood AM, Chen HY, Chang CH, Seitz SP, Trainor GL. (2002) Synthesis and
evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity
relationships at c3. J. Med. Chem. 45(24): 5233-48.
1250. Zhang Y, Desharnais J, Greasley SE, Beardsley GP, Boger DL, Wilson IA.
(2002) Crystal structures of human gar tfase at low and high ph and with substrate betagar.
Biochemistry. 41(48): 14206-15.
1251. Adam GC, Vanderwal CD, Sorensen EJ, Cravatt BF. (2003) (-)-fr182877 is a
potent and selective inhibitor of carboxylesterase-1. Angew. Chem.-Int. Edit. 42(44):
5480-4.
1252. Adams MC, Salmon WC, Gupton SL, Cohan CS, Wittmann T, Prigozhina N,

Waterman-Storer CM. (2003) A high-speed multispectral spinning-disk confocal
microscope system for fluorescent speckle microscopy of living cells. Methods. 29(1):
29-41.
1253. Al-Bassam J, Cui Y, Klopfenstein D, Carragher BO, Vale RD, Milligan RA. (2003)
Distinct conformations of the kinesin unc104 neck regulate a monomer to dimer motor
transition. J. Cell Biol. 163(4): 743-53.
1254. Alper PB, Nguyen KT. (2003) Practical synthesis and elaboration of methyl 7chloroindole-4-carboxylate.
J. Org. Chem. 68(5): 2051-3.
1255. Anderson JC, Schultz PG. (2003) Adaptation of an orthogonal archaeal leucyltrna
and synthetase pair for four-base, amber, and opal suppression. Biochemistry.
42(32): 9598-608.
1256. Aoyagi M, Arvai AS, Tainer JA, Getzoff ED. (2003) Structural basis for endothelial
nitric oxide synthase binding to calmodulin. Embo J. 22(4): 766-75.
1257. Asturias FJ, Craighead JL. (2003) Rna polymerase ii at initiation. Proc. Natl.
Acad. Sci. U. S. A. 100(12): 6893-5.
1258. Babior BM, Takeuchi C, Ruedi J, Gutierrez A, Wentworth P. (2003) Investigating
antibody-catalyzed ozone generation by human neutrophils. Proc. Natl. Acad. Sci. U. S.
A. 100(6): 3031-4.
1259. Baldwin EP, Martin SS, Abel J, Gelato KA, Kim H, Schultz PG, Santoro SW.
(2003) A specificity switch in selected cre recombinase variants is mediated by
macromolecular plasticity and water. Chem. Biol. 10(11): 1085-94.
1260. Baran PS, Guerrero CA, Corey EJ. (2003) Short, enantioselective total synthesis
of okaramine n. J. Am. Chem. Soc. 125(19): 5628-9.
1261. Baran PS, Guerrero CA, Corey EJ. (2003) The first method for protectiondeprotection
of the indole 2,3-pi bond. Org. Lett. 5(11): 1999-2001.
1262. Barnes D, Mayfield SP. (2003) Redox control of posttranscriptional processes in
the chloroplast. Antioxid. Redox Signal. 5(1): 89-94.
1263. Barondeau DP, Putnam CD, Kassmann CJ, Tainer JA, Getzoff ED. (2003)
Mechanism and energetics of green fluorescent protein chromophore synthesis
revealed by trapped intermediate structures. Proc. Natl. Acad. Sci. U. S. A. 100(21):
12111-6.
1264. Bassarello C, Cimino P, Bifulco G, Boger DL, Smith JA, Chazin WJ, Gomez-
Paloma L. (2003) Nmr structure of the (+)-cpi-indole/d(gactaattgac)-d(gtcaatt(a)underbargtc)
covalent complex. Chembiochem. 4(11): 1188-93.
1265. Batalov S, Su AI, Ching KA, Fletcher CF. (2003) Functional annotation of riken
mouse cdna clones using gnf expression atlas. Genome Res. 13(6B): 1556-7.
1266. Baxter I, Tchieu J, Sussman MR, Boutry M, Palmgren MG, Gribskov M, Harper
JF, Axelsen KB. (2003) Genomic comparison of p-type atpase ion pumps in arabidopsis
and rice. Plant Physiol. 132(2): 618-28.
1267. Bayro MJ, Mukhopadhyay J, Swapna GVT, Huang JY, Ma LC, Sineva E, Dawson
PE, Montelione GT, Ebright RH. (2003) Structure of antibacterial peptide microcin j25: A
21-residue lariat protoknot. J. Am. Chem. Soc. 125(41): 12382-3.
1268. Blankenship JW, Dawson PE. (2003) Thermodynamics of a designed protein
catenane. J. Mol. Biol. 327(2): 537-48.

1269. Bobardt MD, Saphire ACS, Hung HC, Yu XC, Van der Schueren B, Zhang Z,
David G, Gallay PA. (2003) Syndecan captures, protects, and transmits hiv to t
lymphocytes. Immunity. 18(1): 27-39.
1270. Boddy CN, Schneider TL, Hotta K, Walsh CT, Khosla C. (2003) Epothilone c
macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of
epothilone polyketide synthase. J. Am. Chem. Soc. 125(12): 3428-9.
1271. Boger DL, Desharnais J, Capps K. (2003) Solution-phase combinatorial libraries:
Modulating cellular signaling by targeting protein-protein or protein-DNA interactions.
Angew. Chem.-Int. Edit. 42(35): 4138-76.
1272. Bruick RK. (2003) Oxygen sensing in the hypoxic response pathway: Regulation
of the hypoxia-inducible transcription factor. Genes Dev. 17(21): 2614-23.
1273. Buck SB, Hardouin C, Ichikawa S, Soenen DR, Gauss CM, Hwang I, Swingle
MR, Bonness KM, Honkanen RE, Boger DL. (2003) Fundamental role of the fostriecin
unsaturated lactone and implications for selective protein phosphatase inhibition. J. Am.
Chem. Soc. 125(51): 15694-5.
1274. Burkart MD. (2003) Metabolic engineering - a genetic toolbox for small molecule
organic synthesis. Org. Biomol. Chem. 1(1): 1-4.
1275. Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu
P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H,
Burton DR, Wilson IA. (2003) Antibody domain exchange is an immunological solution
to carbohydrate cluster recognition. Science. 300(5628): 2065-71.
1276. Cardoso RMF, Daniels DS, Bruns CM, Tainer JA. (2003) Characterization of the
electrophile binding site and substrate binding mode of the 26-kda glutathione stransferase
from schistosoma japonicum. Proteins-Structure Function and Genetics.
51(1): 137-46.
1277. Castle SL, Srikanth GSC. (2003) Catalytic asymmetric synthesis of the central
tryptophan residue of celogentin c. Org. Lett. 5(20): 3611-4.
1278. Chao JA, Prasad GS, White SA, Stout CD, Williamson JR. (2003) Inherent
protein structural flexibility at the rna-binding interface of l30e. J. Mol. Biol. 326(4): 999-
1004.
1279. Chapman E, Bryan MC, Wong CH. (2003) Mechanistic studies of betaarylsulfotransferase
iv. Proc. Natl. Acad. Sci. U. S. A. 100(3): 910-5.
1280. Chen CY, Dagneau P, Grabowski EJJ, Oballa R, O'Shea P, Prasit P, Robichaud
J, Tillyer R, Wang X. (2003) Practical asymmetric synthesis of a potent cathepsin k
inhibitor. Efficient palladium removal following suzuki coupling. J. Org. Chem. 68(7):
2633-8.
1281. Chin JW, Cropp TA, Anderson JC, Mukherji M, Zhang ZW, Schultz PG. (2003)
An expanded eukaryotic genetic code. Science. 301(5635): 964-7.
1282. Cho BS, Schuster TG, Zhu XY, Chang D, Smith GD, Takayama S. (2003)
Passively driven integrated microfluidic system for separation of motile sperm. Anal.
Chem. 75(7): 1671-5.
1283. Chung WH, Craighead JL, Chang WH, Ezeokonkwo C, Bareket-Samish A,
Kornberg RD, Asturias FJ. (2003) Rna polymerase ii/tfiif structure and conserved
organization of the initiation complex. Mol. Cell. 12(4): 1003-13.

1284. Claiborne CF, McCauley JA, Libby BE, Curtis NR, Diggle HJ, Kulagowski JJ,
Michelson SR, Anderson KD, Claremon DA, Freidinger RM, Bednar RA, Mosser SD,
Gaul SL, Connolly TM, Condra CL, Bednar B, Stump GL, Lynch JJ, Macaulay A,
Wafford KA, Koblan KS, Liverton NJ. (2003) Orally efficacious nr2b-selective nmda
receptor antagonists. Bioorg. Med. Chem. Lett. 13(4): 697-700.
1285. Clement AB, Hawkins EG, Lichtman AH, Cravatt BF. (2003) Increased seizure
susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide
hydrolase. J. Neurosci. 23(9): 3916-23.
1286. Collins CH, Yokobayashi Y, Umeno D, Arnold FH. (2003) Engineering proteins
that bind, move, make and break DNA. Curr. Opin. Biotechnol. 14(4): 371-8.
1287. Conkright MD, Guzman E, Flechner L, Su AI, Hogenesch JB, Montminy M.
(2003) Genome-wide analysis of creb target genes reveals a core promoter requirement
for camp responsiveness. Mol. Cell. 11(4): 1101-8.
1288. Cravatt BF, Lichtman AH. (2003) Fatty acid amide hydrolase: An emerging
therapeutic target in the endocannabinoid system. Curr. Opin. Chem. Biol. 7(4): 469-75.
1289. Debaene F, Winssinger N. (2003) Azidopeptide nucleic acid. An alternative
strategy for solid-phase peptide nucleic acid (pna) synthesis. Org. Lett. 5(23): 4445-7.
1290. Dehmelt L, Smart FM, Ozer RS, Halpain S. (2003) The role of microtubuleassociated
protein 2c in the reorganization of microtubules and lamellipodia during
neurite initiation. J. Neurosci. 23(29): 9479-90.
1291. Deiters A, Cropp TA, Mukherji M, Chin JW, Anderson JC, Schultz PG. (2003)
Adding amino acids with novel reactivity to the genetic code of saccharomyces
cerevisiae. J. Am. Chem. Soc. 125(39): 11782-3.
1292. DeSantis G, Liu JJ, Clark DP, Heine A, Wilson IA, Wong CH. (2003) Structurebased
mutagenesis approaches toward expanding the substrate specificity of d-2deoxyribose-5-phosphate
aldolase. Bioorg. Med. Chem. 11(1): 43-52.
1293. Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson
IA, Boger DL. (2003) Design, synthesis and biological evaluation of 10-cf3co-ddacthf
analogues and derivatives as inhibitors of gar tfase and the de novo purine biosynthetic
pathway. Bioorg. Med. Chem. 11(20): 4511-21.
1294. Dickerson TJ, Janda KD. (2003) Glycation of the amyloid beta-protein by a
nicotine metabolite: A fortuitous chemical dynamic between smoking and alzheimer's
disease. Proc. Natl. Acad. Sci. U. S. A. 100(14): 8182-7.
1295. Dickerson TJ, Tremblay MR, Hoffman TZ, Ruiz DI, Janda KD. (2003) Catalysis of
the photo-fries reaction: Antibody-mediated stabilization of high energy states. J. Am.
Chem. Soc. 125(50): 15395-401.
1296. DiDonato M, Craig L, Huff ME, Thayer MM, Cardoso RMF, Kassmann CJ, Lo TP,
Bruns CK, Powers ET, Kelly JW, Getzoff ED, Tainer JA. (2003) Als mutants of human
superoxide dismutase form fibrous aggregates via framework destabilization. J. Mol.
Biol. 332(3): 601-15.
1297. Ding S, Wu TYH, Brinker A, Peters EC, Hur W, Gray NS, Schultz PG. (2003)
Synthetic small molecules that control stem cell fate. Proc. Natl. Acad. Sci. U. S. A.
100(13): 7632-7.
1298. Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern

HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JGA,
Noel JP, Nicolaou KC, Evans RM. (2003) A chemical, genetic, and structural analysis of
the nuclear bile acid receptor fxr. Mol. Cell. 11(4): 1079-92.
1299. Egertova M, Cravatt BF, Elphick MR. (2003) Comparative analysis of fatty acid
amide hydrolase and cb1 cannabinoid receptor expression in the mouse brain:
Evidence of a widespread role for fatty acid amide hydrolase in regulation of
endocannabinoid signaling. Neuroscience. 119(2): 481-96.
1300. Erbel PJA, Card PB, Karakuzu O, Bruick RK, Gardner KH. (2003) Structural
basis for pas domain heterodimerization in the basic helix-loop-helix-pas transcription
factor hypoxia-inducible factor. Proc. Natl. Acad. Sci. U. S. A. 100(26): 15504-9.
1301. Fokas D, Patterson JE, Slobodkin G, Baldino CM. (2003) Access to the
noryohimban [6,5,6,5,6] ring system via an intramolecular furan diels-alder reaction.
Tetrahedron Lett. 44(27): 5137-40.
1302. Gambs C, Dickerson TJ, Mahajan S, Pasternack LB, Janda KD. (2003) Highresolution
diffusion-ordered spectroscopy to probe the microenvironment of jandajel and
merrifield resins. J. Org. Chem. 68(9): 3673-8.
1303. Gao CS, Mao SL, Ronca F, Zhuang SF, Quaranta V, Wirsching P, Janda KD.
(2003) De novo identification of tumor-specific internalizing human antibody-receptor
pairs by phage-display methods. J. Immunol. Methods. 274(1-2): 185-97.
1304. Gearhart MD, Holmbeck SMA, Evans RM, Dyson HJ, Wright PE. (2003)
Monomeric complex of human orphan estrogen related receptor-2 with DNA: A pseudodimer
interface mediates extended half-site recognition. J. Mol. Biol. 327(4): 819-32.
1305. Getzoff ED, Gutwin KN, Genick UK. (2003) Anticipatory active-site motions and
chromophore distortion prime photoreceptor pyp for light activation. Nat. Struct. Biol.
10(8): 663-8.
1306. Gong LY, Hogg JH, Collier J, Wilhelm RS, Soderberg C. (2003) Design and
synthesis of novel ccr3 antagonists. Bioorg. Med. Chem. Lett. 13(20): 3597-600.
1307. Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin
KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi LD, Spence CL, Tengi J,
Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF. (2003) Allosteric
activators of glucokinase: Potential role in diabetes therapy. Science. 301(5631): 370-3.
1308. Gross JL. (2003) A concise stereospecific synthesis of repinotan (bayx3702).
Tetrahedron Lett. 44(47): 8563-5.
1309. Haggarty SJ, Koeller KM, Kau TR, Silver PA, Roberge M, Schreiber SL. (2003)
Small molecule modulation of the human chromatid decatenation checkpoint. Chem.
Biol. 10(12): 1267-79.
1310. Haggarty SJ, Koeller KM, Wong JC, Butcher RA, Schreiber SL. (2003)
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived
deacetylase inhibitors using cell-based assays. Chem. Biol. 10(5): 383-96.
1311. Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL. (2003)
Domain-selective small-molecule inhibitor of histone deacetylase 6 (hdac6)-mediated
tubulin deacetylation. Proc. Natl. Acad. Sci. U. S. A. 100(8): 4389-94.
1312. Halasa NB, Whitlock JA, McCurley TL, Smith JA, Zhu QL, Ochs H, Dermody TS,
Crowe JE. (2003) Fatal hemophagocytic lymphohistiocytosis associated with epstein-

arr virus infection in a patient with a novel mutation in the signaling lymphocytic
activation molecule-associated protein. Clin. Infect. Dis. 37(10): E136-E41.
1313. Ham YW, Tse WC, Boger DL. (2003) High-resolution assessment of protein DNA
binding affinity and selectivity utilizing a fluorescent intercalator displacement (fid)
assay. Bioorg. Med. Chem. Lett. 13(21): 3805-7.
1314. Hammarstrom P, Sekijima Y, White JT, Wiseman RL, Lim A, Costello CE, Altland
K, Garzuly F, Budka H, Kelly JW. (2003) D18g transthyretin is monomeric, aggregation
prone, and not detectable in plasma and cerebrospinal fluid: A prescription for central
nervous system amyloidosis? Biochemistry. 42(22): 6656-63.
1315. Hammarstrom P, Wiseman RL, Powers ET, Kelly JW. (2003) Prevention of
transthyretin amyloid disease by changing protein misfolding energetics. Science.
299(5607): 713-6.
1316. He Y, Wu BG, Yang J, Robinson D, Risen L, Ranken R, Blyn L, Sheng S,
Swayze EE. (2003) 2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial
activities. Bioorg. Med. Chem. Lett. 13(19): 3253-6.
1317. Hearn AS, Stroupe ME, Cabelli DE, Ramilo CA, Luba JP, Tainer JA, Nick HS,
Silverman DN. (2003) Catalytic and structural effects of amino acid substitution at
histidine 30 in human manganese superoxide dismutase: Insertion of valine c gamma
into the substrate access channel. Biochemistry. 42(10): 2781-9.
1318. Henry AA, Romesberg FE. (2003) Beyond a, c, g and t: Augmenting nature's
alphabet. Curr. Opin. Chem. Biol. 7(6): 727-33.
1319. Henry AA, Yu CZ, Romesberg FE. (2003) Determinants of unnatural nucleobase
stability and polymerase recognition. J. Am. Chem. Soc. 125(32): 9638-46.
1320. Himo F, Demko ZP, Noodleman L. (2003) Density functional theory study of the
intramolecular [2+3] cycloaddition of azide to nitriles. J. Org. Chem. 68(23): 9076-80.
1321. Himo F, Demko ZP, Noodleman L, Sharpless KB. (2003) Why is tetrazole
formation by addition of azide to organic nitriles catalyzed by zinc(ii) salts? J. Am.
Chem. Soc. 125(33): 9983-7.
1322. Hof F, Trembleau L, Ullrich EC, Rebek J. (2003) Acetylcholine recognition by a
deep, biomimetic pocket. Angew. Chem.-Int. Edit. 42(27): 3150-3.
1323. Hoggan DB, Chao JA, Prasad GS, Stout CD, Williamson JR. (2003)
Combinatorial crystallization of an rna-protein complex. Acta Crystallogr. Sect. D-Biol.
Crystallogr. 59: 466-73.
1324. Horne WS, Stout CD, Ghadiri MR. (2003) A heterocyclic peptide nanotube. J.
Am. Chem. Soc. 125(31): 9372-6.
1325. Hosfield D, Palan J, Hilgers M, Scheibe D, McRee DE, Stevens RC. (2003) A
fully integrated protein crystallization platform for small-molecule drug discovery. J.
Struct. Biol. 142(1): 207-17.
1326. Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, Kitano H, Arkin AP,
Bornstein BJ, Bray D, Cornish-Bowden A, Cuellar AA, Dronov S, Gilles ED, Ginkel M,
Gor V, Goryanin, II, Hedley WJ, Hodgman TC, Hofmeyr JH, Hunter PJ, Juty NS,
Kasberger JL, Kremling A, Kummer U, Le Novere N, Loew LM, Lucio D, Mendes P,
Minch E, Mjolsness ED, Nakayama Y, Nelson MR, Nielsen PF, Sakurada T, Schaff JC,
Shapiro BE, Shimizu TS, Spence HD, Stelling J, Takahashi K, Tomita M, Wagner J,

Wang J, Forum S. (2003) The systems biology markup language (sbml): A medium for
representation and exchange of biochemical network models. Bioinformatics. 19(4):
524-31.
1327. Huff ME, Balch WE, Kelly JW. (2003) Pathological and functional amyloid
formation orchestrated by the secretory pathway. Curr. Opin. Struct. Biol. 13(6): 674-82.
1328. Huff ME, Page LJ, Balch WE, Kelly JW. (2003) Gelsolin domain 2 ca2+ affinity
determines susceptibility to furin proteolysis and familial amyloidosis of finnish type. J.
Mol. Biol. 334(1): 119-27.
1329. Huh D, Tkaczyk AH, Bahng JH, Chang Y, Wei HH, Grotberg JB, Kim CJ,
Kurabayashi K, Takayama S. (2003) Reversible switching of high-speed air-liquid twophase
flows using electrowetting-assisted flow-pattern change. J. Am. Chem. Soc.
125(48): 14678-9.
1330. Iacovoni JS. (2003) Genehuggers: Database mining and application connectivity
tools for subsequence analyses of the human genome. Bioinformatics. 19(17): 2316-8.
1331. Johnson DW, Hof F, Palmer LC, Martin T, Obst U, Rebek J. (2003) Glycoluril
ribbons tethered by complementary hydrogen bonds. Chem. Commun. (14): 1638-9.
1332. Karanicolas J, Brooks CL. (2003) Improved go-like models demonstrate the
robustness of protein folding mechanisms towards non-native interactions. J. Mol. Biol.
334(2): 309-25.
1333. Karanicolas J, Brooks CL. (2003) The structural basis for biphasic kinetics in the
folding of the ww domain from a formin-binding protein: Lessons for protein design?
Proc. Natl. Acad. Sci. U. S. A. 100(7): 3954-9.
1334. Karanicolas J, Brooks CL. (2003) The importance of explicit chain representation
in protein folding models: An examination of ising-like models. Proteins-Structure
Function and Genetics. 53(3): 740-7.
1335. Kashishian A, Douangpanya H, Clark D, Schlachter ST, Eary CT, Schiro JG,
Huang HM, Burgess LE, Kesicki EA, Halbrook J. (2003) DNA-dependent protein kinase
inhibitors as drug candidates for the treatment of cancer. Mol. Cancer Ther. 2(12): 1257-
64.
1336. Koeller KM, Haggarty SJ, Perkins BD, Leykin I, Wong JC, Kao MCJ, Schreiber
SL. (2003) Chemical genetic modifier screens: Small molecule trichostatin suppressors
as probes of intracellular histone and tubulin acetylation. Chem. Biol. 10(5): 397-410.
1337. Krenitsky PJ, Boger DL. (2003) Synthesis of the (s,s,s)-diastereomer of the 15membered
biaryl ring system of rp 66453. Tetrahedron Lett. 44(21): 4019-22.
1338. Kumar R, Stammer D, Melville WK, Janssen P. (2003) Electromagnetic bias
estimates based on topex, buoy, and wave model data. J. Geophys. Res.-Oceans.
108(C11): 13.
1339. Kumar RM, Joyce GF. (2003) A modular, bifunctional rna that integrates itself
into a target rna. Proc. Natl. Acad. Sci. U. S. A. 100(17): 9738-43.
1340. Kustedjo K, Deechongkit S, Kelly JW, Cravatt BF. (2003) Recombinant
expression, purification, and comparative characterization of torsina and its torsion
dystonia-associated variant delta e-torsina. Biochemistry. 42(51): 15333-41.
1341. La Clair JJ, Burkart MD. (2003) Molecular screening on a compact disc. Org.
Biomol. Chem. 1(18): 3244-9.

1342. Lee A, Rana BK, Schiffer HH, Schork NJ, Brann MR, Insel PA, Weiner DM.
(2003) Distribution analysis of nonsynonymous polymorphisms within the g-proteincoupled
receptor gene family. Genomics. 81(3): 245-8.
1343. Lee LV, Mitchell ML, Huang SJ, Fokin VV, Sharpless KB, Wong CH. (2003) A
potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click
chemistry. J. Am. Chem. Soc. 125(32): 9588-9.
1344. Leung D, Hardouin C, Boger DL, Cravatt BF. (2003) Discovering potent and
selective reversible inhibitors of enzymes in complex proteomes. Nat. Biotechnol. 21(6):
687-91.
1345. Lewis WG, Shen ZX, Finn MG, Siuzdak G. (2003) Desorption/ionization on silicon
(dios) mass spectrometry: Background and applications. Int. J. Mass Spectrom. 226(1):
107-16.
1346. Lim D, Kamotani Y, Cho B, Mazumder J, Takayama S. (2003) Fabrication of
microfluidic mixers and artificial vasculatures using a high-brightness diode-pumped nd :
Yag laser direct write method. Lab Chip. 3(4): 318-23.
1347. Lin PS, Heng SCH, Sim MM. (2003) Syntheses of guanidinoglycosides with the
inventive use of mitsunobu conditions and 1,8-diazabicyclo[5.4.0]undec-7-ene.
Synthesis. (2): 255-61.
1348. Lin YC, Beck Z, Morris GM, Olson AJ, Elder JH. (2003) Structural basis for
distinctions between substrate and inhibitor specificities for feline immunodeficiency
virus and human immunodeficiency virus proteases. J. Virol. 77(12): 6589-600.
1349. Liu H, Ritter TK, Sadamoto R, Sears PS, Wu M, Wong CH. (2003) Acceptor
specificity and inhibition of the bacterial cell-wall glycosyltransferase murg.
Chembiochem. 4(7): 603-9.
1350. Liu HT, Wang L, Brock A, Wong CH, Schultz PG. (2003) A method for the
generation of glycoprotein mimetics. J. Am. Chem. Soc. 125(7): 1702-3.
1351. Liu J, Batkai S, Pacher P, Harvey-White J, Wagner JA, Cravatt BF, Gao B,
Kunos G. (2003) Lipopolysaccharide induces anandamide synthesis in macrophages
via cd14/mapk/phosphoinositide 3-kinase/nf-kappa b independently of platelet-activating
factor. J. Biol. Chem. 278(45): 45034-9.
1352. Lohr JB, Kuczenski R, Niculescu AB. (2003) Oxidative mechanisms and tardive
dyskinesia. CNS Drugs. 17(1): 47-62.
1353. Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson
IA, Benkovic SJ, Boger DL. (2003) 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-
5,6,7,8-tetrahydrofolic acid: A potential inhibitor of gar transformylase and aicar
transformylase. Bioorg. Med. Chem. 11(20): 4503-9.
1354. Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA,
Benkovic SJ, Boger DL. (2003) Design, synthesis, and biological evaluation of simplified
alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues
as potential inhibitors of gar transformylase and aicar transformylase. Bioorg. Med.
Chem. 11(20): 4487-501.
1355. Martinez-Wittinghan FJ, Sellitto C, Li LP, Gong XH, Brink PR, Mathias RT, White
TW. (2003) Dominant cataracts result from incongruous mixing of wild-type lens
connexins. J. Cell Biol. 161(5): 969-78.

1356. Matsuda S, Henry AA, Schultz PG, Romesberg FE. (2003) The effect of minorgroove
hydrogen-bond acceptors and donors on the stability and replication of four
unnatural base pairs. J. Am. Chem. Soc. 125(20): 6134-9.
1357. Matthews RG, Smith AE, Zhou ZHS, Taurog RE, Bandarian V, Evans JC, Ludwig
M. (2003) Cobalamin-dependent and cobalamin-independent methionine synthases:
Are there two solutions to the same chemical problem? Helv. Chim. Acta. 86(12): 3939-
54.
1358. McComas CC, Crowley BM, Boger DL. (2003) Partitioning the loss in vancomycin
binding affinity for d-ala-d-lac into lost h-bond and repulsive lone pair contributions. J.
Am. Chem. Soc. 125(31): 9314-5.
1359. McComas CC, Crowley BM, Hwang I, Boger DL. (2003) Synthesis and evaluation
of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl
esters. Bioorg. Med. Chem. Lett. 13(17): 2933-6.
1360. McCombie SW, Tagat JR, Vice SF, Lin SI, Steensma R, Palani A, Neustadt BR,
Baroudy BM, Strizki JM, Endres M, Cox K, Dan N, Chou CC. (2003) Piperazine-based
ccr5 antagonists as hiv-1 inhibitors. Iii: Synthesis, antiviral and pharmacokinetic profiles
of symmetrical heteroaryl carboxamides. Bioorg. Med. Chem. Lett. 13(3): 567-71.
1361. McGinness KE, Joyce GF. (2003) In search of an rna replicase ribozyme. Chem.
Biol. 10(1): 5-14.
1362. McKinney MK, Cravatt BF. (2003) Evidence for distinct roles in catalysis for
residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase. J. Biol.
Chem. 278(39): 37393-9.
1363. Mehl RA, Anderson JC, Santoro SW, Wang L, Martin AB, King DS, Horn DM,
Schultz PG. (2003) Generation of a bacterium with a 21 amino acid genetic code. J. Am.
Chem. Soc. 125(4): 935-9.
1364. Miller JE, Gradinaru C, Crane BR, Di Bilio AJ, Wehbi WA, Un S, Winkler JR, Gray
HB. (2003) Spectroscopy and reactivity of a photogenerated tryptophan radical in a
structurally defined protein environment. J. Am. Chem. Soc. 125(47): 14220-1.
1365. Mong TKK, Huang CY, Wong CH. (2003) A new reactivity-based one-pot
synthesis of n-acetyllactosamine oligomers. J. Org. Chem. 68(6): 2135-42.
1366. Moore SD, McGinness KE, Sauer RT. (2003) A glimpse into tmrna-mediated
ribosome rescue. Science. 300(5616): 72-3.
1367. Moss JA, Coyle AR, Ahn JM, Meijler MM, Offer J, Janda KD. (2003) Tandem
imac-hplc purification of a cocaine-binding scfv antibody. J. Immunol. Methods. 281(1-
2): 143-8.
1368. Nicolaou KC, Chen DYK, Li YW, Qian WY, Ling TT, Vyskocil S, Koftis TV,
Govindasamy M, Uesaka N. (2003) Total synthesis of the proposed azaspiracid-1
structure, part 2: Coupling of the c1-c20, c21-c27, and c28-c40 fragments and
completion and synthesis. Angew. Chem.-Int. Edit. 42(31): 3649-53.
1369. Nicolaou KC, Evans RM, Roecker AJ, Hughes R, Downes M, Pfefferkorn JA.
(2003) Discovery and optimization of non-steroidal fxr agonists from natural product-like
libraries. Org. Biomol. Chem. 1(6): 908-20.
1370. Nicolaou KC, Fylaktakidou KC, Monenschein H, Li YW, Weyershausen B,
Mitchell HJ, Wei HX, Guntupalli P, Hepworth D, Sugita K. (2003) Total synthesis of

apoptolidin: Construction of enantiomerically pure fragments. J. Am. Chem. Soc.
125(50): 15433-42.
1371. Nicolaou KC, Li YW, Sugita K, Monenschein H, Guntupalli P, Mitchell HJ,
Fylaktakidou KC, Vourloumis D, Giannakakou P, O'Brate A. (2003) Total synthesis of
apoptolidin: Completion of the synthesis and analogue synthesis and evaluation. J. Am.
Chem. Soc. 125(50): 15443-54.
1372. Nicolaou KC, Li YW, Uesaka N, Koftis TV, Vyskocil S, Ling TT, Govindasamy M,
Qian W, Bernal F, Chen DYK. (2003) Total synthesis of the proposed azaspiracid-1
structure, part 1: Construction of the enantiomerically pure c1-c20, c21-c27, and c28c40
fragments. Angew. Chem.-Int. Edit. 42(31): 3643-8.
1373. Nicolaou KC, Mathison CJN, Montagnon T. (2003) New reactions of ibx:
Oxidation of nitrogen- and sulfur-containing substrates to afford useful synthetic
intermediates. Angew. Chem.-Int. Edit. 42(34): 4077-82.
1374. Nicolaou KC, Montagnon T, Snyder SA. (2003) Tandem reactions, cascade
sequences, and biomimetic strategies in total synthesis. Chem. Commun. (5): 551-64.
1375. Nicolaou KC, Nevalainen M, Zak M, Bulat S, Bella M, Safina BS. (2003) Synthetic
studies on thiostrepton: Construction of thiostrepton analogues with the thiazolinecontaining
macrocycle. Angew. Chem.-Int. Edit. 42(29): 3418-24.
1376. Nicolaou KC, Rao PB, Hao JL, Reddy MV, Rassias G, Huang XH, Chen DYK,
Snyder SA. (2003) The second total synthesis of diazonamide a. Angew. Chem.-Int.
Edit. 42(15): 1753-8.
1377. Nicolaou KC, Roecker AJ, Hughes R, van Summeren R, Pfefferkorn JA,
Winssinger N. (2003) Novel strategies for the solid phase synthesis of substituted
indolines and indoles. Bioorg. Med. Chem. 11(3): 465-76.
1378. Nicolaou KC, Roecker AJ, Monenschein H, Guntupalli P, Follmann M. (2003)
Studies towards the synthesis of azadirachtin: Enantioselective entry into the
azadirachtin framework through cascade reactions. Angew. Chem.-Int. Edit. 42(31):
3637-42.
1379. Nicolaou KC, Sasmal PK, Xu H, Namoto K, Ritzen A. (2003) Total synthesis of 1o-methyllateriflorone.
Angew. Chem.-Int. Edit. 42(35): 4225-9.
1380. Nicolaou KC, Snyder SA. (2003) Cascade reactions in total synthesis - recent
advances. Actual Chim. (4-5): 83-8.
1381. Niece KL, Hartgerink JD, Donners J, Stupp SI. (2003) Self-assembly combining
two bioactive peptide-amphiphile molecules into nanofibers by electrostatic attraction. J.
Am. Chem. Soc. 125(24): 7146-7.
1382. Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK. (2003) Profiling
receptor tyrosine kinase activation by using ab microarrays. Proc. Natl. Acad. Sci. U. S.
A. 100(16): 9330-5.
1383. Nomanbhoy TK, Rosenblum J, Aban A, Burbaum JJ. (2003) Inhibitor focusing:
Direct selection of drug targets from proteomes using activity-based probes. Assay Drug
Dev. Technol. 1(1): 137-46.
1384. Nordin BE, Schimmel P. (2003) Transiently misacylated trna is a primer for
editing of misactivated adenylates by class i aminoacyl-trna synthetases. Biochemistry.
42(44): 12989-97.

1385. Notz W, Tanaka F, Watanabe S, Chowdari NS, Turner JM, Thayumanavan R,
Barbas CF, 3rd. (2003) The direct organocatalytic asymmetric mannich reaction:
Unmodified aldehydes as nucleophiles. J. Org. Chem. 68(25): 9624-34.
1386. Panda S, Provencio I, Tu DC, Pires SS, Rollag MD, Castrucci AM, Pletcher MT,
Sato TK, Wiltshire T, Andahazy M, Kay SA, Van Gelder RN, Hogenesch JB. (2003)
Melanopsin is required for non-image-forming photic responses in blind mice. Science.
301(5632): 525-7.
1387. Panda S, Sato TK, Hampton GM, Hogenesch JB. (2003) An array of insights:
Application of DNA chip technology in the study of cell biology. Trends Cell Biol. 13(3):
151-6.
1388. Pantophlet R, Saphire EO, Poignard P, Parren P, Wilson IA, Burton DR. (2003)
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal
antibodies with the cd4 binding site of human immunodeficiency virus type 1 gp120. J.
Virol. 77(1): 642-58.
1389. Parrish JP, Kastrinsky DB, Boger DL. (2003) Synthesis and x-ray analysis of an
unprecedented and stable 2-aza-4,4-spirocyclopropacyclohexadienone. Org. Lett. 5(14):
2577-9.
1390. Parrish JP, Kastrinsky DB, Hwang I, Boger DL. (2003) Synthesis and evaluation
of duocarmycin and cc-1065 analogues incorporating the 1,2,9,9atetrahydrocyclopropa[c]benz[e]-3-azaindol-4-one
(cba) alkylation subunit. J. Org. Chem.
68(23): 8984-90.
1391. Parrish JP, Kastrinsky DB, Stauffer F, Hedrick MP, Hwang I, Boger DL. (2003)
Establishment of substituent effects in the DNA binding subunit of cbi analogues of the
duocarmycins and cc-1065. Bioorg. Med. Chem. 11(17): 3815-38.
1392. Parrish JP, Kastrinsky DB, Wolkenberg SE, Igarashi Y, Boger DL. (2003) DNA
alkylation properties of yatakemycin. J. Am. Chem. Soc. 125(36): 10971-6.
1393. Peluso P, Wilson DS, Do D, Tran H, Venkatasubbaiah M, Quincy D, Heidecker B,
Poindexter K, Tolani N, Phelan M, Witte K, Jung LS, Wagner P, Nock S. (2003)
Optimizing antibody immobilization strategies for the construction of protein microarrays.
Anal. Biochem. 312(2): 113-24.
1394. Phillips GR, Tanaka H, Frank M, Elste A, Fidler L, Benson DL, Colman DR.
(2003) Gamma-protocadherins are targeted to subsets of synapses and intracellular
organelles in neurons. J. Neurosci. 23(12): 5096-104.
1395. Purse BW, Ballester P, Rebek J. (2003) Reactivity and molecular recognition:
Amine methylation by an introverted ester. J. Am. Chem. Soc. 125(48): 14682-3.
1396. Rader C, Turner JM, Heine A, Shabat D, Sinha SC, Wilson IA, Lerner RA, Barbas
CF. (2003) A humanized aldolase antibody for selective chemotherapy and adaptor
immunotherapy. J. Mol. Biol. 332(4): 889-99.
1397. Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE,
Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MTA, Sacchettini JC,
Kelly JW. (2003) Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis,
evaluation, and mechanism of action. Angew. Chem.-Int. Edit. 42(24): 2758-61.
1398. Redman JE, Wilcoxen KM, Ghadiri MR. (2003) Automated mass spectrometric
sequence determination of cyclic peptide library members. J. Comb. Chem. 5(1): 33-40.

1399. Redmond WL, Hernandez J, Sherman LA. (2003) Deletion of naive cd8 t cells
requires persistent antigen and is not programmed by an initial signal from the
tolerogenic apc. J. Immunol. 171(12): 6349-54.
1400. Redwan ERM, Larsen NA, Zhou B, Wirsching P, Janda KD, Wilson IA. (2003)
Expression and characterization of a humanized cocaine-binding antibody. Biotechnol.
Bioeng. 82(5): 612-8.
1401. Ritter TK, Mong KKT, Liu HT, Nakatani T, Wong CH. (2003) A programmable
one-pot oligosaccharide synthesis for diversifying the sugar domains of natural
products: A case study of vancomycin. Angew. Chem.-Int. Edit. 42(38): 4657-60.
1402. Rosenblum JS, Kozarich JW. (2003) Proyl peptidases: A serine protease
subfamily with high potential for drug discovery. Curr. Opin. Chem. Biol. 7(4): 496-504.
1403. Rosenfeld RJ, Goodsell DS, Musah RA, Morris GM, Goodin DB, Olson AJ.
(2003) Automated docking of ligands to an artificial active site: Augmenting
crystallographic analysis with computer modeling. J. Comput.-Aided Mol. Des. 17(8):
525-36.
1404. Rudolph MG, Kelker MS, Schneider TR, Yeates TO, Oseroff V, Heidary DK,
Jennings PA, Wilson IA. (2003) Use of multiple anomalous dispersion to phase highly
merohedrally twinned crystals of interleukin-1 beta. Acta Crystallogr. Sect. D-Biol.
Crystallogr. 59: 290-8.
1405. Saghatelian A, Guckian KM, Thayer DA, Ghadiri MR. (2003) DNA detection and
signal amplification via an engineered allosteric enzyme. J. Am. Chem. Soc. 125(2):
344-5.
1406. Saghatelian A, Volcker NH, Guckian KM, Lin VSY, Ghadiri MR. (2003) DNAbased
photonic logic gates: And, nand, and inhibit. J. Am. Chem. Soc. 125(2): 346-7.
1407. Santoro SW, Anderson JC, Lakshman V, Schultz PG. (2003) An archaebacteriaderived
glutamyl-trna synthetase and trna pair for unnatural amino acid mutagenesis of
proteins in escherichia coli. Nucleic Acids Res. 31(23): 6700-9.
1408. Sato TK, Panda S, Kay SA, Hogenesch JB. (2003) DNA arrays: Applications and
implications for circadian biology. J. Biol. Rhythms. 18(2): 96-105.
1409. Sawyer JS, Anderson BD, Beight DW, Campbell RM, Jones ML, Herron DK,
Lampe JW, McCowan JR, McMillen WT, Mort N, Parsons S, Smith ECR, Vieth M, Wier
LC, Yan L, Zhang FM, Yingling JM. (2003) Synthesis and activity of new aryl- and
heteroaryl- substituted pyrazole inhibitors of the transforming growth factor-b type i
receptor kinase domain. J. Med. Chem. 46(19): 3953-6.
1410. Segal DJ, Beerli RR, Blancafort P, Dreier B, Effertz K, Huber A, Koksch B, Lund
CV, Magnenat L, Valente D, Barbas CF. (2003) Evaluation of a modular strategy for the
construction of novel polydactyl zinc finger DNA-binding proteins. Biochemistry. 42(7):
2137-48.
1411. Sheinerman FB, Al-Lazikani B, Honig B. (2003) Sequence, structure and
energetic determinants of phosphopeptide selectivity of sh2 domains. J. Mol. Biol.
334(4): 823-41.
1412. Shim J, Bersano-Begey TF, Zhu XY, Tkaczyk AH, Linderman JJ, Takayama S.
(2003) Micro- and nanotechnologies for studying cellular function. Curr. Top. Med.
Chem. 3(6): 687-703.

1413. Shin DS, Pellegrini L, Daniels DS, Yelent B, Craig L, Bates D, Yu DS, Shivji MK,
Hitomi C, Arvai AS, Volkmann N, Tsuruta H, Blundell TL, Venkitaraman AR, Tainer JA.
(2003) Full-length archaeal rad51 structure and mutants: Mechanisms for rad51
assembly and control by brca2. Embo J. 22(17): 4566-76.
1414. Silvestri MG, Desantis G, Mitchell M, Wong CH. (2003) Asymmetric aldol
reactions using aldolases. Topics in Stereochemistry. 23: 267-342.
1415. Soenen DR, Hwang I, Hedrick MP, Boger DL. (2003) Multidrug resistance
reversal activity of key ningalin analogues. Bioorg. Med. Chem. Lett. 13(10): 1777-81.
1416. Soenen DR, Zimpleman JM, Boger DL. (2003) Synthesis and inverse electron
demand diels-alder reactions of 3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine. J. Org.
Chem. 68(9): 3593-8.
1417. Speers AE, Adam GC, Cravatt BF. (2003) Activity-based protein profiling in vivo
using a copper(i)-catalyzed azide-alkyne [3+2] cycloaddition. J. Am. Chem. Soc.
125(16): 4686-7.
1418. Stanfield RL, Ghiara JB, Saphire EM, Profy AT, Wilson IA. (2003) Recurring
conformation of the human immunodeficiency virus type 1 gp120 v3 loop. Virology.
315(1): 159-73.
1419. Stroupe ME, Leech HK, Daniels DS, Warren MJ, Getzoff ED. (2003) Cysg
structure reveals tetrapyrrole-binding features and novel regulation of siroheme
biosynthesis. Nat. Struct. Biol. 10(12): 1064-73.
1420. Suh RS, Phadke N, Ohl DA, Takayama S, Smith GD. (2003) Rethinking
gamete/embryo isolation and culture with microfluidics. Hum. Reprod. Update. 9(5):
451-61.
1421. Takayama S, Ostuni E, LeDuc P, Naruse K, Ingber DE, Whitesides GM. (2003)
Selective chemical treatment of cellular microdomains using multiple laminar streams.
Chem. Biol. 10(2): 123-30.
1422. Tamiya J, Sorensen EJ. (2003) A spontaneous bicyclization facilitates a
synthesis of (-)-hispidospermidin. Tetrahedron. 59(35): 6921-32.
1423. Tao Y, Xie ZY, Chen WQ, Glazebrook J, Chang HS, Han B, Zhu T, Zou GZ,
Katagiri F. (2003) Quantitative nature of arabidopsis responses during compatible and
incompatible interactions with the bacterial pathogen pseudomonas syringae. Plant Cell.
15(2): 317-30.
1424. Tasber ES, Garbaccio RM. (2003) Thermodynamic equilibration of
dihydropyridone enolates: Application to the total synthesis of (+/-)-epiuleine.
Tetrahedron Lett. 44(51): 9185-8.
1425. Thomann D, Dorn J, Sorger PK, Danuser G. (2003) Automatic fluorescent tag
localization ii: Improvement in super-resolution by relative tracking. J. Microsc.-Oxf. 211:
230-48.
1426. Thompson MJ, Bashford D, Noodleman L, Getzoff ED. (2003)
Photoisomerization and proton transfer in photoactive yellow protein. J. Am. Chem. Soc.
125(27): 8186-94.
1427. Thorpe IF, Brooks CL. (2003) Barriers to hydride transfer in wild type and mutant
dihydrofolate reductase from e-coli. J. Phys. Chem. B. 107(50): 14042-51.
1428. Tomassini JE, Boots E, Gan L, Graham P, Munshi V, Wolanski B, Fay JF, Getty

K, LaFemina R. (2003) An in vitro flaviviridae replicase system capable of authentic rna
replication. Virology. 313(1): 274-85.
1429. Tsao TS, Tomas E, Murrey HE, Hug C, Lee DH, Ruderman NB, Heuser JE,
Lodish HF. (2003) Role of disulfide bonds in acrp30/adiponectin structure and signaling
specificity - different oligomers activate different signal transduction pathways. J. Biol.
Chem. 278(50): 50810-7.
1430. Tse WC, Ishii T, Boger DL. (2003) Comprehensive high-resolution analysis of
hairpin polyamides utilizing a fluorescent intercalator displacement (fid) assay. Bioorg.
Med. Chem. 11(20): 4479-86.
1431. Tsui V, Macke T, Case DA. (2003) A novel method for finding trna genes. RNA-
Publ. RNA Soc. 9(5): 507-17.
1432. Ujaque G, Tantillo DJ, Hu YF, Houk KN, Hotta K, Hilvert D. (2003) Catalysis on
the coastline: Theozyme, molecular dynamics, and free energy perturbation analysis of
antibody 21d8 catalysis of the decarboxylation of 5-nitro-3-carboxybenzisoxazole. J.
Comput. Chem. 24(1): 98-110.
1433. Vanderwal CD, Vosburg DA, Weiler S, Sorensen EJ. (2003) An enantioselective
synthesis of fr182877 provides a chemical rationalization of its structure and affords
multigram quantities of its direct precursor. J. Am. Chem. Soc. 125(18): 5393-407.
1434. Vosburg DA, Weiler S, Sorensen E. (2003) Concise stereocontrolled routes to
fumagillol, fumagillin, and tnp-470. Chirality. 15(2): 156-66.
1435. Wada M, Hsu CC, Franke D, Mitchell M, Heine A, Wilson I, Wong CH. (2003)
Directed evolution of n-acetylneuraminic acid aldolase to catalyze enantiomeric aldol
reactions. Bioorg. Med. Chem. 11(9): 2091-8.
1436. Wang L, Xie JM, Deniz AA, Schultz PG. (2003) Unnatural amino acid
mutagenesis of green fluorescent protein. J. Org. Chem. 68(1): 174-6.
1437. Wang Q, Chan TR, Hilgraf R, Fokin VV, Sharpless KB, Finn MG. (2003)
Bioconjugation by copper(i)-catalyzed azide-alkyne [3+2] cycloaddition. J. Am. Chem.
Soc. 125(11): 3192-3.
1438. Wanner J, Tang DT, McComas CC, Crowley BM, Jiang WL, Moss J, Boger DL.
(2003) A new and improved method for deglycosidation of glycopeptide antibiotics
exemplified with vancomycin, ristocetin, and ramoplanin. Bioorg. Med. Chem. Lett.
13(6): 1169-73.
1439. Ward A, Moody MF, Sheehan B, Milligan RA, Carragher B. (2003) Windex: A
toolset for indexing helices. J. Struct. Biol. 144(1-2): 172-83.
1440. Watanabe K, Wang CCC, Boddy CN, Cane DE, Khosla C. (2003) Understanding
substrate specificity of polyketide synthase modules by generating hybrid multimodular
synthases. J. Biol. Chem. 278(43): 42020-6.
1441. Wei CC, Crane BR, Stuehr DJ. (2003) Tetrahydrobiopterin radical enzymology.
Chem. Rev. 103(6): 2365-83.
1442. Wentworth P, Nieva J, Takeuchi C, Galve R, Wentworth AD, Dilley RB, DeLaria
GA, Saven A, Babior BM, Janda KD, Eschenmoser A, Lerner RA. (2003) Evidence for
ozone formation in human atherosclerotic arteries. Science. 302(5647): 1053-6.
1443. Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA. (2003) Structure of
avian aicar transformylase with a multisubstrate adduct inhibitor beta-dadf identifies the

folate binding site. Biochemistry. 42(37): 10904-14.
1444. Wong CH, Bryan MC. (2003) Sugar arrays in microtiter plates. Methods Enzymol.
362: 218-25.
1445. Wong CH, Liang FS. (2003) Surface plasmon resonance study of rnaaminoglycoside
interactions. Methods Enzymol. 362: 340-53.
1446. Wu CY, Chang CF, Chen JSY, Wong CH, Lin CH. (2003) Rapid diversity-oriented
synthesis in microtiter plates for in situ screening: Discovery of potent and selective
alpha-fucosidase inhibitors. Angew. Chem.-Int. Edit. 42(38): 4661-4.
1447. Wu E, Pache L, Von Seggern DJ, Mullen TM, Mikyas Y, Stewart PL, Nemerow
GR. (2003) Flexibility of the adenovirus fiber is required for efficient receptor interaction.
J. Virol. 77(13): 7225-35.
1448. Wu GS, Robertson DH, Brooks CL, Vieth M. (2003) Detailed analysis of gridbased
molecular docking: A case study of cdocker - a charmm-based md docking
algorithm. J. Comput. Chem. 24(13): 1549-62.
1449. Wu TYH, Schultz PG, Ding S. (2003) One-pot two-step microwave-assisted
reaction in constructing 4,5-disubstituted pyrazolopyrimidines. Org. Lett. 5(20): 3587-90.
1450. Wu TYH, Wagner KW, Bursulaya B, Schultz PG, Deveraux QL. (2003)
Development and characterization of nonpeptidic small molecule inhibitors of the
xiap/caspase-3 interaction. Chem. Biol. 10(8): 759-67.
1451. Wu Y, Wood MD, Tao Y, Katagiri F. (2003) Direct delivery of bacterial avirulence
proteins into resistant arabidopsis protoplasts leads to hypersensitive cell death. Plant J.
33(1): 131-7.
1452. Xu J, Wang HS, Sim MM. (2003) First synthesis of (+/-)-c-3-prenylated
flavanones. Synth. Commun. 33(15): 2737-50.
1453. Yamamoto K, Garbaccio RM, Stachel SJ, Solit DB, Chiosis G, Rosen N,
Danishefsky SJ. (2003) Total synthesis as a resource in the discovery of potentially
valuable antitumor agents: Cycloproparadicicol. Angew. Chem.-Int. Edit. 42(11): 1280-4.
1454. Yeung BKS, Tse WC, Boger DL. (2003) Determination of binding affinities of
triplex forming oligonucleotides using a fluorescent intercalator displacement (fid) assay.
Bioorg. Med. Chem. Lett. 13(21): 3801-4.
1455. Yohn CB, Pusateri L, Barbosa V, Lehmann R. (2003) 1(3)malignant brain tumor
and three novel genes are required for drosophila germ-cell formation. Genetics. 165(4):
1889-900.
1456. Zhang Y, Desharnais J, Marsilje TH, Li CL, Hedrick MP, Gooljarsingh LT,
Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA. (2003) Rational design,
synthesis, evaluation, and crystal structure of a potent inhibitor of human gar tfase: 10-
(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry. 42(20):
6043-56.
1457. Zhao G, Wan W, Mansouri S, Alfaro JF, Bassler BL, Cornell KA, Zhou ZHS.
(2003) Chemical synthesis of s-ribosyl-l-homocysteine and activity assay as a luxs
substrate. Bioorg. Med. Chem. Lett. 13(22): 3897-900.
1458. Zhong GF. (2003) A facile and rapid route to highly enantiopure 1,2-diols by
novel catalytic asymmetric alpha-aminoxylation of aldehydes. Angew. Chem.-Int. Edit.
42(35): 4247-50.

1459. Zhu XY, Larsen NA, Basran A, Bruce NC, Wilson IA. (2003) Observation of an
arsenic adduct in an acetyl esterase crystal structure. J. Biol. Chem. 278(3): 2008-14.
1460. Zwick MB, Parren P, Saphire EO, Church S, Wang M, Scott JK, Dawson PE,
Wilson IA, Burton DR. (2003) Molecular features of the broadly neutralizing
immunoglobulin g1 b12 required for recognition of human immunodeficiency virus type 1
gp120. J. Virol. 77(10): 5863-76.
1461. Adam GC, Burbaum J, Kozarich JW, Patricelli MP, Cravatt BF. (2004) Mapping
enzyme active sites in complex proteomes. J. Am. Chem. Soc. 126(5): 1363-8.
1462. Adams MC, Matov A, Yarar D, Gupton SL, Danuser G, Waterman-Storer CM.
(2004) Signal analysis of total internal reflection fluorescent speckle microscopy (tir-fsm)
and wide-field epi-fluorescence fsm of the actin cytoskeleton and focal adhesions in
living cells. J. Microsc.-Oxf. 216: 138-52.
1463. Agnelli T, Sucheck SJ, Marby KA, Rabuka D, Yao SL, Sears PS, Liang FS, Wong
CH. (2004) Dimeric aminoglycosides as antibiotics. Angew. Chem.-Int. Edit. 43(12):
1562-6.
1464. Ahmad S, Ngu K, Combs DW, Wu SC, Weinstein DS, Liu W, Chen BC,
Chandrasena G, Dorso CR, Kirby M, Atwal KS. (2004) Aminoimidazoles as bioisosteres
of acylguanidines: Novel, potent, selective and orally bioavailable inhibitors of the
sodium hydrogen exchanger isoform-1. Bioorg. Med. Chem. Lett. 14(1): 177-80.
1465. Ait-Azzouzene D, Skog P, Retter M, Kouskoff V, Hertz M, Lang J, Kench J,
Chumley M, Melamed D, Sudaria J, Gavin A, Martensson A, Verkoczy L, Duong B, Vela
J, Nemazee D. (2004) Tolerance-induced receptor selection: Scope, sensitivity, locus
specificity, and relationship to lymphocyte-positive selection. Immunol. Rev. 197: 219-
30.
1466. Alfaro JF, Zhang T, Wynn DP, Karschner EL, Zhou ZS. (2004) Synthesis of luxs
inhibitors targeting bacterial cell-cell communication. Org. Lett. 6(18): 3043-6.
1467. Aliahmad P, O'Flaherty E, Han P, Goularte OD, Wilkinson B, Satake M,
Molkentin JD, Kaye J. (2004) Tox provides a link between calcineurin activation and cd8
lineage commitment. J. Exp. Med. 199(8): 1089-99.
1468. Anderson JC, Wu N, Santoro SW, Lakshman V, King DS, Schultz PG. (2004) An
expanded genetic code with a functional quadruplet codon. Proc. Natl. Acad. Sci. U. S.
A. 101(20): 7566-71.
1469. Ashkenasy G, Jagasia R, Yadav M, Ghadiri MR. (2004) Design of a directed
molecular network. Proc. Natl. Acad. Sci. U. S. A. 101(30): 10872-7.
1470. Azad SC, Monory K, Marsicano G, Cravatt BF, Lutz B, Zieglgansberger W,
Rammes G. (2004) Circuitry for associative plasticity in the amygdala involves
endocannabinoid signaling. J. Neurosci. 24(44): 9953-61.
1471. Baran PS, O'Malley DP, Zografos AL. (2004) Sceptrin as a potential biosynthetic
precursor to complex pyrrole - pyrrole-imidazole alkaloids: The total synthesis of
ageliferin. Angew. Chem.-Int. Edit. 43(20): 2674-7.
1472. Baran PS, Richter JM. (2004) Direct coupling of indoles with carbonyl
compounds: Short, enantioselective, gram-scale synthetic entry into the hapalindole and
fischerindole alkaloid families. J. Am. Chem. Soc. 126(24): 7450-1.
1473. Baran PS, Zografos AL, O'Malley DP. (2004) Short total synthesis of (+/-)-

sceptrin. J. Am. Chem. Soc. 126(12): 3726-7.
1474. Barglow KT, Cravatt BF. (2004) Discovering disease-associated enzymes by
proteome reactivity profiling. Chem. Biol. 11(11): 1523-31.
1475. Barluenga S, Lopez P, Moulin E, Winssinger N. (2004) Modular asymmetric
synthesis of pochonin c. Angew. Chem.-Int. Edit. 43(26): 3467-70.
1476. Barnes D, Cohen A, Bruick RK, Kantardjieff K, Fowler S, Efuet E, Mayfield SP.
(2004) Identification and characterization of a novel rna binding protein that associates
with the 5 '-untranslated region of the chloroplast psba mrna. Biochemistry. 43(26):
8541-50.
1477. Baxter SM, Rosenblum JS, Knutson S, Nelson MR, Montimurro JS, Di Gennaro
JA, Speir JA, Burbaum JJ, Fetrow JS. (2004) Synergistic computational and
experimental proteomics approaches for more accurate detection of active serine
hydrolases in yeast. Mol. Cell. Proteomics. 3(3): 209-25.
1478. Belting M, Dorrell MI, Sandgren S, Aguilar E, Ahamed J, Dorfleutner A, Carmeliet
P, Mueller BM, Friedlander M, Ruf W. (2004) Regulation of angiogenesis by tissue
factor cytoplasmic domain signaling. Nat. Med. 10(5): 502-9.
1479. Best MD, Brik A, Chapman E, Lee LV, Cheng WC, Wong CH. (2004) Rapid
discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in
microplates followed by in situ screening. Chembiochem. 5(6): 811-9.
1480. Biros SM, Ullrich EC, Hof F, Trembleau L, Rebek J. (2004) Kinetically stable
complexes in water: The role of hydration and hydrophobicity. J. Am. Chem. Soc.
126(9): 2870-6.
1481. Blaess S, Graus-Porta D, Belvindrah R, Radakovits R, Pons S, Littlewood-Evans
A, Senften M, Guo HL, Li YQ, Miner JH, Reichardt LF, Muller U. (2004) Beta 1-integrins
are critical for cerebellar granule cell precursor proliferation. J. Neurosci. 24(13): 3402-
12.
1482. Blixt O, Head S, Mondala T, Scanlan C, Huflejt ME, Alvarez R, Bryan MC, Fazio
F, Calarese D, Stevens J, Razi N, Stevens DJ, Skehel JJ, van Die I, Burton DR, Wilson
IA, Cummings R, Bovin N, Wong CH, Paulson JC. (2004) Printed covalent glycan array
for ligand profiling of diverse glycan binding proteins. Proc. Natl. Acad. Sci. U. S. A.
101(49): 17033-8.
1483. Bock C, Coleman M, Collins B, Davis J, Foulds G, Gold L, Greef C, Heil J, Heilig
JS, Hicke B, Hurst MN, Husar GM, Miller D, Ostroff R, Petach H, Schneider D, Vant-Hull
B, Waugh S, Weiss A, Wilcox SK, Zichi D. (2004) Photoaptamer arrays applied to
multiplexed proteomic analysis. Proteomics. 4(3): 609-18.
1484. Boddy CN. (2004) Sweetening cyclic peptide libraries. Chem. Biol. 11(12): 1599-
600.
1485. Boddy CN, Hotta K, Tse ML, Watts RE, Khosla C. (2004) Precursor-directed
biosynthesis of epothilone in escherichia coli. J. Am. Chem. Soc. 126(24): 7436-7.
1486. Boess FG, Hendrix M, van der Staay FJ, Erb C, Schreiber R, van Staveren W, de
Vente J, Prickaerts J, Blokland A, Koenig G. (2004) Inhibition of phosphodiesterase 2
increases neuronal cgmp, synaptic plasticity and memory performance.
Neuropharmacology. 47(7): 1081-92.
1487. Bong D, Tam I, Breslow R. (2004) Oligothiophene isocyanides for platinum-

ased molecular electronic applications. J. Am. Chem. Soc. 126(38): 11796-7.
1488. Bong DTY, Chan EWL, Diercks R, Dosa PI, Haley MM, Matzger AJ, Miljanic OS,
Vollhardt KPC, Bond AD, Teat SJ, Stanger A. (2004) Syntheses of syn and anti
doublebent [5]phenylene. Org. Lett. 6(13): 2249-52.
1489. Bornes S, Boulard M, Hieblot C, Zanibellato C, Iacovoni JS, Prats H, Touriol C.
(2004) Control of the vascular endothelial growth factor internal ribosome entry site
(ires) activity and translation initiation by alternatively spliced coding sequences. J. Biol.
Chem. 279(18): 18717-26.
1490. Bracey MH, Cravatt BF, Stevens RC. (2004) Structural commonalities among
integral membrane enzymes. FEBS Lett. 567(2-3): 159-65.
1491. Bryan MC, Fazio F, Lee HK, Huang CY, Chang A, Best MD, Calarese DA, Blixt
C, Paulson JC, Burton D, Wilson IA, Wong CH. (2004) Covalent display of
oligosaccharide arrays in microtiter plates. J. Am. Chem. Soc. 126(28): 8640-1.
1492. Bryan MC, Lee LV, Wong CH. (2004) High-throughput identification of
fucosyltransferase inhibitors using carbohydrate microarrays. Bioorg. Med. Chem. Lett.
14(12): 3185-8.
1493. Bryan MC, Wong CH. (2004) Aminoglycoside array for the high-throughput
analysis of small molecule-rna interactions. Tetrahedron Lett. 45(18): 3639-42.
1494. Buddha MR, Keery KM, Crane BR. (2004) An unusual tryptophanyl trna
synthetase interacts with nitric oxide synthase in deinococcus radiodurans. Proc. Natl.
Acad. Sci. U. S. A. 101(45): 15881-6.
1495. Buddha MR, Tao T, Parry RJ, Crane BR. (2004) Regioselective nitration of
tryptophan by a complex between bacterial nitric-oxide synthase and tryptophanyl-trna
synthetase. J. Biol. Chem. 279(48): 49567-70.
1496. Buey RM, Diaz JF, Andreu JM, O'Brate A, Giannakakou P, Nicolaou KC, Sasmal
PK, Ritzen A, Namoto K. (2004) Interaction of epothilone analogs with the paclitaxel
binding site: Relationship between binding affinity, microtubule stabilization, and
cytotoxicity. Chem. Biol. 11(2): 225-36.
1497. Bunick CG, Nelson MR, Mangahas S, Hunter MJ, Sheehan JH, Mizoue LS,
Bunick GJ, Chazin WJ. (2004) Designing sequence to control protein function in an efhand
protein. J. Am. Chem. Soc. 126(19): 5990-8.
1498. Carrera MRA, Ashley JA, Hoffman TZ, Isomura S, Wirsching P, Koob GF, Janda
KD. (2004) Investigations using immunization to attenuate the psychoactive effects of
nicotine. Bioorg. Med. Chem. 12(3): 563-70.
1499. Carrera MRA, Kaufmann GF, Mee JM, Meijler MM, Koob GF, Janda KD. (2004)
Treating cocaine addiction with viruses. Proc. Natl. Acad. Sci. U. S. A. 101(28): 10416-
21.
1500. Carrera MRA, Meijler MM, Janda KD. (2004) Cocaine pharmacology and current
pharmacothetherapies for its abuse. Bioorg. Med. Chem. 12(19): 5019-30.
1501. Chan TR, Hilgraf R, Sharpless KB, Fokin VV. (2004) Polytriazoles as copper(i)stabilizing
ligands in catalysis. Org. Lett. 6(17): 2853-5.
1502. Chang CF, Ho CW, Wu CY, Chao TA, Wong CH, Lin CH. (2004) Discovery of
picomolar slow tight-binding inhibitors of alpha-fucosidase (vol 11, pg 1301, 2004).
Chem. Biol. 11(11): 1595-.

1503. Chang CF, Ho CW, Wu CY, Chao TA, Wong CH, Lin CH. (2004) Discovery of
picomolar slow tight-binding inhibitors of alpha-fucosidase. Chem. Biol. 11(9): 1301-6.
1504. Chao JA, Williamson JR. (2004) Joint x-ray and nmr refinement of the yeast l30emrna
complex. Structure. 12(7): 1165-76.
1505. Chapados BR, Hosfield DJ, Han S, Qiu JZ, Yelent B, Shen BH, Tainer JA. (2004)
Structural basis for fen-1 substrate specificity and pcna-mediated activation in DNA
replication and repair. Cell. 116(1): 39-50.
1506. Chapman E, Best MD, Hanson SR, Wong CH. (2004) Sulfotransferases:
Structure, mechanism, biological activity, inhibition, and synthetic utility. Angew. Chem.-
Int. Edit. 43(27): 3526-48.
1507. Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K,
Desai A. (2004) A conserved protein network controls assembly of the outer kinetochore
and its ability to sustain tension. Genes Dev. 18(18): 2255-68.
1508. Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CH. (2004) Studies on
the immuno-modulating and anti-tumor activities of ganoderma lucidum (reishi)
polysaccharides. Bioorg. Med. Chem. 12(21): 5595-601.
1509. Chen SB, Zhang QS, Wu X, Schultz PG, Ding S. (2004) Dedifferentiation of
lineage-committed cells by a small molecule. J. Am. Chem. Soc. 126(2): 410-1.
1510. Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA.
(2004) Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide
ribonucleotide transformylase/imp cyclohydrolase in complex with potent sulfonylcontaining
antifolates. J. Biol. Chem. 279(17): 18034-45.
1511. Chiang KP, Gerber AL, Sipe JC, Cravatt BF. (2004) Reduced cellular expression
and activity of the p129t mutant of human fatty acid amide hydrolase: Evidence for a link
between defects in the endocannabinoid system and problem drug use. Hum. Mol.
Genet. 13(18): 2113-9.
1512. Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S,
Cox D, Hamley P, Mallinder P, Millichip I, Nicholls DJ, Rosenfeld RJ, St-Gallay SA,
Tainer J, Tinker AC, Wallace AV. (2004) 2-aminopyridines as highly selective inducible
nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen
substitution. J. Med. Chem. 47(12): 3320-3.
1513. Converso A, Saaidi PL, Sharpless KB, Finn MG. (2004) Nucleophilic substitution
by grignard reagents on sulfur mustards. J. Org. Chem. 69(21): 7336-9.
1514. Cravatt BF, Lichtman AH. (2004) The endogenous cannabinoid system and its
role in nociceptive behavior. J. Neurobiol. 61(1): 149-60.
1515. Cravatt BF, Saghatelian A, Hawkins EG, Clement AB, Bracey MH, Lichtman AH.
(2004) Functional disassociation of the central and peripheral fatty acid amide signaling
systems. Proc. Natl. Acad. Sci. U. S. A. 101(29): 10821-6.
1516. Crowley BM, Mori Y, McComas CC, Tang DT, Boger DL. (2004) Total synthesis
of the ristocetin aglycon. J. Am. Chem. Soc. 126(13): 4310-7.
1517. Daniels DS, Woo TT, Luu KX, Noll DM, Clarke ND, Pegg AE, Tainer JA. (2004)
DNA binding and nucleotide flipping by the human DNA repair protein agt. Nat. Struct.
Mol. Biol. 11(8): 714-20.
1518. Dawson PE, Leumann CJ. (2004) Challenge complex biological function with

smart chemistry - editorial overview. Curr. Opin. Chem. Biol. 8(6): 567-9.
1519. Debaene F, Mejias L, Harris JL, Winssinger N. (2004) Synthesis of a pnaencoded
cysteine protease inhibitor library. Tetrahedron. 60(39): 8677-90.
1520. Deechongkit S, Dawson PE, Kelly JW. (2004) Toward assessing the positiondependent
contributions of backbone hydrogen bonding to beta-sheet folding
thermodynamics employing amide-to-ester perturbations. J. Am. Chem. Soc. 126(51):
16762-71.
1521. Deechongkit S, Nguyen H, Powers ET, Dawson PE, Gruebele M, Kelly JW.
(2004) Context-dependent contributions of backbone hydrogen bonding to beta-sheet
folding energetics. Nature. 430(6995): 101-5.
1522. Deechongkit S, You SL, Kelly JW. (2004) Synthesis of all nineteen appropriately
protected chiral alpha-hydroxy acid equivalents of the alpha-amino acids for boc solidphase
depsi-peptide synthesis. Org. Lett. 6(4): 497-500.
1523. Demarest SJ, Deechongkit S, Dyson HJ, Evans RM, Wright PE. (2004) Packing,
specificity, and mutability at the binding interface between the p160 coactivator and
creb-binding protein. Protein Sci. 13(1): 203-10.
1524. Dickerson TJ, Lovell T, Meijler MM, Noodleman L, Janda KD. (2004) Nornicotine
aqueous aldol reactions: Synthetic and theoretical investigations into the origins of
catalysis. J. Org. Chem. 69(20): 6603-9.
1525. Dickerson TJ, Reed NN, LaClair JJ, Janda KD. (2004) A precipitator for the
detection of thiophilic metals in aqua. J. Am. Chem. Soc. 126(50): 16582-6.
1526. Dickerson TJ, Yamamoto N, Janda KD. (2004) Antibody-catalyzed oxidative
degradation of nicotine using riboflavin. Bioorg. Med. Chem. 12(18): 4981-7.
1527. Dickerson TJ, Yamamoto N, Ruiz DI, Janda KD. (2004) Immunological
consequences of methamphetamine protein glycation. J. Am. Chem. Soc. 126(37):
11446-7.
1528. Ding S, Schultz PG. (2004) A role for chemistry in stem cell biology. Nat.
Biotechnol. 22(7): 833-40.
1529. Dominy BN, Minoux H, Brooks CL. (2004) An electrostatic basis for the stability
of thermophilic proteins. Proteins. 57(1): 128-41.
1530. Dominy BN, Shakhnovich EI. (2004) Native atom types for knowledge-based
potentials: Application to binding energy prediction. J. Med. Chem. 47(18): 4538-58.
1531. Dorrell MI, Aguilar E, Weber C, Friedlander M. (2004) Global gene expression
analysis of the developing postnatal mouse retina. Invest. Ophthalmol. Vis. Sci. 45(3):
1009-19.
1532. Dorrell MI, Otani A, Aguilar E, Moreno SK, Friedlander M. (2004) Adult bone
marrow-derived stem cells use r-cadherin to target sites of neovascularization in the
developing retina. Blood. 103(9): 3420-7.
1533. Du X, Tabeta K, Hoebe K, Liu HQ, Mann N, Mudd S, Crozat K, Sovath S, Gong
XH, Beutler B. (2004) Velvet, a dominant egfr mutation that causes wavy hair and
defective eyelid development in mice. Genetics. 166(1): 331-40.
1534. Egertova M, Michael GJ, Cravatt BF, Elphick MR. (2004) Fatty acid amide
hydrolase in brain ventricular epithelium: Mutually exclusive patterns of expression in
mouse and rat. J. Chem. Neuroanat. 28(3): 171-81.

1535. Erickson JA, Jalaie M, Robertson DH, Lewis RA, Vieth M. (2004) Lessons in
molecular recognition: The effects of ligand and protein flexibility on molecular docking
accuracy. J. Med. Chem. 47(1): 45-55.
1536. Evans WE, Guy RK. (2004) Gene expression as a drug discovery tool. Nature
Genet. 36(3): 214-5.
1537. Fa M, Radeghieri A, Henry AA, Romesberg FE. (2004) Expanding the substrate
repertoire of a DNA polymerase by directed evolution. J. Am. Chem. Soc. 126(6): 1748-
54.
1538. Fazio F, Bryan MC, Lee HK, Chang A, Wong CH. (2004) Assembly of sugars on
polystyrene plates: A new facile microarray fabrication technique. Tetrahedron Lett.
45(12): 2689-92.
1539. Felding-Habermann B, Lerner RA, Lillo A, Zhuang SF, Weber MR, Arrues S, Gao
CS, Mao SL, Saven A, Janda KD. (2004) Combinatorial antibody libraries from cancer
patients yield ligand-mimetic arg-gly-asp-containing immunoglobulins that inhibit breast
cancer metastasis. Proc. Natl. Acad. Sci. U. S. A. 101(49): 17210-5.
1540. Feldman AK, Colasson B, Fokin VV. (2004) One-pot synthesis of 1,4disubstituted
1,2,3-triazoles from in situ generated azides. Org. Lett. 6(22): 3897-9.
1541. Futai N, Gu W, Takayama S. (2004) Rapid prototyping of microstructures with
bell-shaped cross-sections and its application to deformation-based microfluidic valves.
Adv. Mater. 16(15): 1320-+.
1542. Gan L, Conway JF, Firek BA, Cheng NQ, Hendrix RW, Steven AC, Johnson JE,
Duda RL. (2004) Control of crosslinking by quaternary structure changes during
bacteriophage hk97 maturation. Mol. Cell. 14(5): 559-69.
1543. Gao JY, Sun XR, Martinez-Wittinghan FJ, Gong XH, White TW, Mathias RT.
(2004) Connections between connexins, calcium, and cataracts in the lens. J. Gen.
Physiol. 124(4): 289-300.
1544. Garcin ED, Bruns CM, Lloyd SJ, Hosfield DJ, Tiso M, Gachhui R, Stuehr DJ,
Tainer JA, Getzoff ED. (2004) Structural basis for isozyme-specific regulation of electron
transfer in nitric-oxide synthase. J. Biol. Chem. 279(36): 37918-27.
1545. Gentle IE, De Souza DP, Baca M. (2004) Direct production of proteins with nterminal
cysteine for site-specific conjugation. Bioconjugate Chem. 15(3): 658-63.
1546. Graber S, Maiti S, Halpain S. (2004) Cathepsin b-like proteolysis and marcks
degradation in sublethal nmda-induced collapse of dendritic spines.
Neuropharmacology. 47(5): 706-13.
1547. Granville DJ, Tashakkor B, Takeuchi C, Gustafsson AB, Huang CQ, Sayen MR,
Wentworth P, Yeager M, Gottlieb RA. (2004) Reduction of ischemia and reperfusioninduced
myocardial damage by cytochrome p450 inhibitors. Proc. Natl. Acad. Sci. U. S.
A. 101(5): 1321-6.
1548. Grechez-Cassiau A, Panda S, Lacoche S, Teboul M, Azmi S, Laudet V,
Hogenesch JB, Taneja R, Delaunay F. (2004) The transcriptional repressor stra13
regulates a subset of peripheral circadian outputs. J. Biol. Chem. 279(2): 1141-50.
1549. Greenleaf WB, Jefferson J, Perry P, Hearn AS, Cabelli DE, Lepock JR, Stroupe
ME, Tainer JA, Nick HS, Silverman DN. (2004) Role of hydrogen bonding in the active
site of human manganese superoxide dismutase. Biochemistry. 43(22): 7038-45.

1550. Gu W, Zhu XY, Futai N, Cho BS, Takayama S. (2004) Computerized microfluidic
cell culture using elastomeric channels and braille displays. Proc. Natl. Acad. Sci. U. S.
A. 101(45): 15861-6.
1551. Gulyas AI, Cravatt BF, Bracey MH, Dinh TP, Piomelli D, Boscia F, Freund TF.
(2004) Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and
postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Eur. J.
Neurosci. 20(2): 441-58.
1552. Guvench O, Brooks CL. (2004) Efficient approximate all-atom solvent accessible
surface area method parameterized for folded and denatured protein conformations. J.
Comput. Chem. 25(8): 1005-14.
1553. Hamdouchi C, Keyser H, Collins E, Jaramillo C, De Diego JE, Spencer CD,
Dempsey JA, Anderson BD, Leggett T, Stamm NB, Schultz RM, Watkins SA, Cocke K,
Lemke S, Burke TF, Beckmann RP, Dixon JT, Gurganus TM, Rankl NB, Houck KA,
Zhang FM, Vieth M, Espinosa J, Timm DE, Campbell RM, Patel BKR, Brooks HB.
(2004) The discovery of a new structural class of cyclin-dependent kinase inhibitors,
aminoimidazo[1,2-a]pyridines. Mol. Cancer Ther. 3(1): 1-9.
1554. Hanson S, Best M, Bryan MC, Wong CH. (2004) Chemoenzymatic synthesis of
oligosaccharides and glycoproteins. Trends Biochem.Sci. 29(12): 656-63.
1555. Hanson SR, Best MD, Wong CH. (2004) Sulfatases: Structure, mechanism,
biological activity, inhibition, and synthetic utility. Angew. Chem.-Int. Edit. 43(43): 5736-
63.
1556. Harris J, Mason DE, Li J, Burdick KW, Backes BJ, Chen T, Shipway A, Van
Heeke G, Gough L, Ghaemmaghami A, Shakib F, Debaene F, Winssinger N. (2004)
Activity profile of dust mite allergen extract using substrate libraries and functional
proteomic microarrays. Chem. Biol. 11(10): 1361-72.
1557. Hartgerink JD. (2004) Covalent capture: A natural complement to self-assembly.
Curr. Opin. Chem. Biol. 8(6): 604-9.
1558. He Y, Yang J, Wu BG, Risen L, Swayze EE. (2004) Synthesis and biological
evaluations of novel benzimidazoles as potential antibacterial agents. Bioorg. Med.
Chem. Lett. 14(5): 1217-20.
1559. He Y, Yang J, Wu BG, Robinson D, Sprankle K, Kung PP, Lowery K, Mohan V,
Hofstadler S, Swayze EE, Griffey R. (2004) Synthesis and evaluation of novel bacterial
rrna-binding benzimidazoles by mass spectrometry. Bioorg. Med. Chem. Lett. 14(3):
695-9.
1560. Hendricks CL, Ross JR, Pichersky E, Noel JP, Zhou ZS. (2004) An enzymecoupled
colorimetric assay for s-adenosylmethionine-dependent methyltransferases.
Anal. Biochem. 326(1): 100-5.
1561. Hendrix M, Kallus C. (2004) Phosphodiesterase inhibitors: A chemogenomic
view. Methods and Principles in Medicinal Chemistry. 22: 243-88.
1562. Henry AA, Jimenez R, Hanway D, Romesberg FE. (2004) Preliminary
characterization of light harvesting in e-coli DNA photolyase. Chembiochem. 5(8): 1088-
94.
1563. Henry AA, Olsen AG, Matsuda S, Yu CZ, Geierstanger BH, Romesberg FE.
(2004) Efforts to expand the genetic alphabet: Identification of a replicable unnatural

DNA self-pair. J. Am. Chem. Soc. 126(22): 6923-31.
1564. Horne WS, Yadav MK, Stout CD, Ghadiri MR. (2004) Heterocyclic peptide
backbone modifications in an alpha-helical coiled coil. J. Am. Chem. Soc. 126(47):
15366-7.
1565. Hsu HY, Hua KF, Lin CC, Lin CH, Hsu J, Wong CH. (2004) Extract of reishi
polysaccharides induces cytokine expression via tlr4-modulated protein kinase signaling
pathways. J. Immunol. 173(10): 5989-99.
1566. Hsu N, Cai DY, Damodaran K, Gomez RF, Keck JG, Laborde E, Lum RT, Macke
TJ, Martin G, Schow SR, Simon RJ, Villar HO, Wick MM, Beroza P. (2004) Novel
cyclooxygenase-1 inhibitors discovered using affinity fingerprints. J. Med. Chem. 47(20):
4875-80.
1567. Hu YF, Houk KN, Kikuchi K, Hotta K, Hilvert D. (2004) Nonspecific medium
effects versus specific group positioning in the antibody and albumin catalysis of the
base-promoted ring-opening reactions of benzisoxazoles. J. Am. Chem. Soc. 126(26):
8197-205.
1568. Huitron-Resendiz S, Sanchez-Alavez M, Wills DN, Cravatt BF, Henriksen SJ.
(2004) Characterization of the sleep-wake patterns in mice lacking fatty acid amide
hydrolase. Sleep. 27(5): 857-65.
1569. Hurshman AR, White JT, Powers ET, Kelly JW. (2004) Transthyretin aggregation
under partially denaturing conditions is a downhill polymerization. Biochemistry. 43(23):
7365-81.
1570. Hussain D, Haydon MJ, Wang Y, Wong E, Sherson SM, Young J, Camakaris J,
Harper JF, Cobbett CS. (2004) P-type atpase heavy metal transporters with roles in
essential zinc homeostasis in arabidopsis. Plant Cell. 16(5): 1327-39.
1571. Iacovoni JS, Cohen SB, Berg T, Vogt PK. (2004) V-jun targets showing an
expression pattern that correlates with the transformed cellular phenotype. Oncogene.
23(33): 5703-6.
1572. Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K. (2004) Deficiency of
carbohydrate response element-binding protein (chrebp) reduces lipogenesis as well as
glycolysis. Proc. Natl. Acad. Sci. U. S. A. 101(19): 7281-6.
1573. Jaramillo C, de Diego JE, Hamdouchi C, Collins E, Keyser H, Sanchez-Martinez
C, del Prado M, Norman B, Brooks HB, Watkins SA, Spencer CD, Dempsey JA,
Anderson BD, Campbell RM, Leggett T, Patel B, Schultz RM, Espinosa J, Vieth M,
Zhang FM, Timm DE. (2004) Aminoimidazo[1,2-a]pyridines as a new structural class of
cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation.
Bioorg. Med. Chem. Lett. 14(24): 6095-9.
1574. Jessani N, Cravatt BF. (2004) The development and application of methods for
activity-based protein profiling. Curr. Opin. Chem. Biol. 8(1): 54-9.
1575. Jessani N, Humphrey M, McDonald WH, Niessen S, Masuda K, Gangadharan B,
Yates JR, Mueller BM, Cravatt BF. (2004) Carcinoma and stromal enzyme activity
profiles associated with breast tumor growth in vivo. Proc. Natl. Acad. Sci. U. S. A.
101(38): 13756-61.
1576. Johnson JR, Florens L, Carucci DJ, Yates JR. (2004) Proteomics in malaria. J.
Proteome Res. 3(2): 296-306.

1577. Jontes JD, Emond MR, Smith SJ. (2004) In vivo trafficking and targeting of ncadherin
to nascent presynaptic terminals. J. Neurosci. 24(41): 9027-34.
1578. Kamikubo Y, De Guzman R, Kroon G, Curriden S, Neels JG, Churchill MJ,
Dawson P, Oldziej S, Jagielska A, Scheraga HA, Loskutoff DJ, Dyson HJ. (2004)
Disulfide bonding arrangements in active forms of the somatomedin b domain of human
vitronectin. Biochemistry. 43(21): 6519-34.
1579. Kang SA, Marjavaara PJ, Crane BR. (2004) Electron transfer between
cytochrome c and cytochome c peroxidase in single crystals. J. Am. Chem. Soc.
126(35): 10836-7.
1580. Karanicolas J, Brooks CL. (2004) Integrating folding kinetics and protein function:
Biphasic kinetics and dual binding specificity in a ww domain. Proc. Natl. Acad. Sci. U.
S. A. 101(10): 3432-7.
1581. Kastrinsky DB, Boger DL. (2004) Effective asymmetric synthesis of 1,2,9,9atetrahydrocyclopropa[c]benzo[e]indol-4-one
(cbi). J. Org. Chem. 69(7): 2284-9.
1582. Kelker MS, Debler EW, Wilson IA. (2004) Crystal structure of mouse triggering
receptor expressed on myeloid cells 1 (trem-1) at 1.76 angstrom. J. Mol. Biol. 344(5):
1175-81.
1583. Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wuthrich K, Wilson IA. (2004)
Crystal structure of human triggering receptor expressed on myeloid cells 1 (trem-1) at
1.47 angstrom. J. Mol. Biol. 342(4): 1237-48.
1584. Kers JA, Wach MJ, Krasnoff SB, Widom J, Cameron KD, Bukhalid RA, Gibson
DM, Crane BR, Loria R. (2004) Nitration of a peptide phytotoxin by bacterial nitric oxide
synthase. Nature. 429(6987): 79-82.
1585. Khachemoune A, Johnson DS. (2004) Reconstruction of a large surgical defect
of the nose. Dermatologic Surgery. 30(8): 1187-90.
1586. Kim YS, Moss JA, Janda MD. (2004) Biological tuning of synthetic tactics in
solid-phase synthesis: Application to a beta(1-42). J. Org. Chem. 69(22): 7776-8.
1587. Klostermeier D, Sears P, Wong CH, Millar DP, Williamson JR. (2004) A threefluorophore
fret assay for high-throughput screening of small-molecule inhibitors of
ribosome assembly. Nucleic Acids Res. 32(9): 2707-15.
1588. La Clair JJ, Foley TL, Schegg TR, Regan CM, Burkart MD. (2004) Manipulation
of carrier proteins in antibiotic biosynthesis. Chem. Biol. 11(2): 195-201.
1589. Lajiness MS, Vieth M, Erickson J. (2004) Molecular properties that influence oral
drug-like behavior. Curr. Opin. Drug Discov. Dev. 7(4): 470-7.
1590. Larsen NA, de Prada P, Deng SX, Mittal A, Braskett M, Zhu X, Wilson IA, Landry
DW. (2004) Crystallographic and biochemical analysis of cocaine-degrading antibody
l5a10. Biochemistry. 43(25): 8067-76.
1591. Larsen NA, Harrison SC. (2004) Crystal structure of the spindle assembly
checkpoint protein bub3. J. Mol. Biol. 344(4): 885-92.
1592. Le Roch KG, Johnson JR, Florens L, Zhou YY, Santrosyan A, Grainger M, Yan
SF, Williamson KC, Holder AA, Carucci DJ, Yates JR, Winzeler EA. (2004) Global
analysis of transcript and protein levels across the plasmodium falciparum life cycle.
Genome Res. 14(11): 2308-18.
1593. Lebsack AD, Gunzner J, Wang BW, Pracitto R, Schaffhauser H, Santini A, Aiyar

J, Bezverkov R, Munoz B, Liu WS, Venkatraman S. (2004) Identification and synthesis
of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the
alpha(2)delta-1 subunit of voltage gated calcium channel. Bioorg. Med. Chem. Lett.
14(10): 2463-7.
1594. Lee HK, Scanlan CN, Huang CY, Chang AY, Calarese DA, Dwek RA, Rudd PM,
Burton DR, Wilson IA, Wong CH. (2004) Reactivity-based one-pot synthesis of
oligomannoses: Defining antigens recognized by 2g12, a broadly neutralizing anti-hiv-1
antibody. Angew. Chem.-Int. Edit. 43(8): 1000-3.
1595. Lee KK, Gan L, Tsuruta H, Hendrix RW, Duda RL, Johnson JE. (2004) Evidence
that a local refolding event triggers maturation of hk97 bacteriophage capsid. J. Mol.
Biol. 340(3): 419-33.
1596. Lee LV, Bower KE, Liang FS, Shi J, Wu D, Sucheck SJ, Vogt PK, Wong CH.
(2004) Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides. J.
Am. Chem. Soc. 126(15): 4774-5.
1597. Leman L, Orgel L, Ghadiri MR. (2004) Carbonyl sulfide-mediated prebiotic
formation of peptides. Science. 306(5694): 283-6.
1598. Lewis WG, Magallon FG, Fokin VV, Finn MG. (2004) Discovery and
characterization of catalysts for azide-alkyne cycloaddition by fluorescence quenching.
J. Am. Chem. Soc. 126(30): 9152-3.
1599. Li CL, Xu L, Wolan DW, Wilson IA, Olson AJ. (2004) Virtual screening of human
5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the nci diversity
set by use of autodock to identify novel nonfolate inhibitors. J. Med. Chem. 47(27):
6681-90.
1600. Liang FS, Wang SK, Nakatani T, Wong CH. (2004) Targeting rnas with
tobramycin analogues. Angew. Chem.-Int. Edit. 43(47): 6496-500.
1601. Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL,
Cravatt BF. (2004) Reversible inhibitors of fatty acid amide hydrolase that promote
analgesia: Evidence for an unprecedented combination of potency and selectivity. J.
Pharmacol. Exp. Ther. 311(2): 441-8.
1602. Lichtman AH, Shelton CC, Advani T, Cravatt BF. (2004) Mice lacking fatty acid
amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. Pain.
109(3): 319-27.
1603. Lillo AM, Sun CZ, Gao CS, Ditzel H, Parrish J, Gauss CM, Moss J, Felding-
Habermann B, Wirsching P, Boger DL, Janda KD. (2004) A human single-chain
antibody specific for integrin alpha(3)beta(1) capable of cell internalization and delivery
of antitumor agents. Chem. Biol. 11(7): 897-906.
1604. Lin H, Thayer DA, Wong CH, Walsh CT. (2004) Macrolactamization of
glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase.
Chem. Biol. 11(12): 1635-42.
1605. Ling IT, Florens L, Dluzewski AR, Kaneko O, Grainger M, Lim B, Tsuboi T,
Hopkins JM, Johnson JR, Torii M, Bannister LH, Yates JR, Holder AA, Mattei D. (2004)
The plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to
the host erythrocyte upon invasion. Mol. Microbiol. 52(1): 107-18.
1606. Liu F, Whitton JL, Slifka MK. (2004) The rapidity with which virus-specific cd8(+) t

cells initiate ifn-gamma synthesis increases markedly over the course of infection and
correlates with immunodominance. J. Immunol. 173(1): 456-62.
1607. Liu JJ, Hsu CC, Wong CH. (2004) Sequential aldol condensation catalyzed by
dera mutant ser238asp and a formal total synthesis of atorvastatin. Tetrahedron Lett.
45(11): 2439-41.
1608. Liu JJ, Numa MMD, Liu HT, Huang SJ, Sears P, Shikhman AR, Wong CH. (2004)
Synthesis and high-throughput screening of n-acetyl-beta-hexosaminidase inhibitor
libraries targeting osteoarthritis. J. Org. Chem. 69(19): 6273-83.
1609. Liu ZJ, Dominy BN, Shakhnovich EI. (2004) Structural mining: Self-consistent
design on flexible protein-peptide docking and transferable binding affinity potential. J.
Am. Chem. Soc. 126(27): 8515-28.
1610. Lo JF, Hayashi M, Woo-Kim S, Tian B, Huang JF, Fearns C, Takayama S,
Zapata JM, Yang Y, Lee JD. (2004) Tid1, a cochaperone of the heat shock 70 protein
and the mammalian counterpart of the drosophila tumor suppressor 1(2)tid, is critical for
early embryonic development and cell survival. Mol. Cell. Biol. 24(6): 2226-36.
1611. Lovato MA, Swairjo MA, Schimmel P. (2004) Positional recognition of a trna
determinant dependent on a peptide insertion. Mol. Cell. 13(6): 843-51.
1612. Lund CV, Blancafort P, Popkov M, Barbas CF. (2004) Promoter-targeted phage
display selections with preassembled synthetic zinc finger libraries for endogenous gene
regulation. J. Mol. Biol. 340(3): 599-613.
1613. Mandel AL, La Clair JJ, Burkart MD. (2004) Modular synthesis of pantetheine and
phosphopantetheine. Org. Lett. 6(26): 4801-3.
1614. Manetsch R, Krasinski A, Radic Z, Raushel J, Taylor P, Sharpless KB, Kolb HC.
(2004) In situ click chemistry: Enzyme inhibitors made to their own specifications. J. Am.
Chem. Soc. 126(40): 12809-18.
1615. Marinzi C, Offer J, Longhi R, Dawson PE. (2004) An o-nitrobenzyl scaffold for
peptide ligation: Synthesis and applications. Bioorg. Med. Chem. 12(10): 2749-57.
1616. Marsilje TH, Roses JB, Calderwood EF, Stroud SG, Forsyth NE, Blackburn C,
Yowe DL, Miao WY, Drabic SV, Bohane MD, Daniels JS, Li P, Wu LJ, Patane MA,
Claiborne CF. (2004) Synthesis and biological evaluation of imidazole-based small
molecule antagonists of the melanocortin 4 receptor (mc4-r). Bioorg. Med. Chem. Lett.
14(14): 3721-5.
1617. Massa F, Marsicano G, Hermann H, Cannich A, Monory K, Cravatt BF, Ferri GL,
Sibaev A, Storr M, Lutz B. (2004) The endogenous cannabinoid system protects against
colonic inflammation. J. Clin. Invest. 113(8): 1202-9.
1618. McDonald WH, Tabb DL, Sadygov RG, MacCoss MJ, Venable J, Graumann J,
Johnson JR, Cociorva D, Yates JR. (2004) Ms1, ms2, and sqt - three unified, compact,
and easily parsed file formats for the storage of shotgun proteomic spectra and
identifications. Rapid Commun. Mass Spectrom. 18(18): 2162-8.
1619. McGinness KE, Sauer RT. (2004) Ribosomal protein s1 binds mrna and tmrna
similarly but plays distinct roles in translation of these molecules. Proc. Natl. Acad. Sci.
U. S. A. 101(37): 13454-9.
1620. Meijler MM, Hom LG, Kaufmann GF, McKenzie KM, Sun CZ, Moss JA,
Matsushita M, Janda KD. (2004) Synthesis and biological validation of a ubiquitous

quorum-sensing molecule. Angew. Chem.-Int. Edit. 43(16): 2106-8.
1621. Meng JC, Averbuj C, Lewis WG, Siuzdak G, Finn MG. (2004) Cleavable linkers
for porous silicon-based mass spectrometry. Angew. Chem.-Int. Edit. 43(10): 1255-60.
1622. Merkel AB, Major LL, Errey JC, Burkart MD, Field RA, Walsh CT, Naismith JN.
(2004) The position of a key tyrosine in dtdp-4-keto-6-deoxy-d-glucose-5-epimerase
(evad) alters the substrate profile for this rmlc-like enzyme. J. Biol. Chem. 279(31):
32684-91.
1623. Metanis N, Brik A, Dawson PE, Keinan E. (2004) Electrostatic interactions
dominate the catalytic contribution of arg39 in 4-oxalocrotonate tautomerase. J. Am.
Chem. Soc. 126(40): 12726-7.
1624. Mettath S, Srikanth GSC, Dangerfield BS, Castle SL. (2004) Asymmetric
synthesis beta-hydroxy amino acids via aldol reactions catalyzed by chiral ammonium
salts. J. Org. Chem. 69(19): 6489-92.
1625. Meunier S, Strable E, Finn MG. (2004) Crosslinking of and coupling to viral
capsid proteins by tyrosine oxidation. Chem. Biol. 11(3): 319-26.
1626. Mohammed KA, Hossain CF, Zhang L, Bruick RK, Zhou YD, Nagle DG. (2004)
Laurenditerpenol, a new diterpene from the tropical marine alga laurencia intricata that
potently inhibits hif-1 mediated hypoxic signaling in breast tumor cells. J. Nat. Prod.
67(12): 2002-7.
1627. Mora-Garcia S, Vert G, Yin YH, Cano-Delgado A, Cheong H, Chory J. (2004)
Nuclear protein phosphatases with kelch-repeat domains modulate the response to bras
sino steroids in arabidopsis. Genes Dev. 18(4): 448-60.
1628. Muller-Sieburg CE, Cho RH, Karlsson L, Huang JF, Sieburg HB. (2004) Myeloidbiased
hematopoietic stem cells have extensive self-renewal capacity but generate
diminished lymphoid progeny with impaired il-7 responsiveness. Blood. 103(11): 4111-
8.
1629. Navarro M, Carrera MRA, del Arco I, Trigo JM, Koob GF, de Fonseca FR. (2004)
Cannabinoid receptor antagonist reduces heroin self-administration only in dependent
rats. Eur. J. Pharmacol. 501(1-3): 235-7.
1630. Nedvetzki S, Gonen E, Assayag N, Reich R, Williams RO, Thurmond RL, Huang
JF, Neudecker BA, Wang FS, Turley EA, Naor D. (2004) Rhamm, a receptor for
hyaluronan-mediated motility, compensates for cd44 in inflamed cd44-knockout mice: A
different interpretation of redundancy. Proc. Natl. Acad. Sci. U. S. A. 101(52): 18081-6.
1631. Nicolaou KC, Chen DYK, Huang XH, Ling TT, Bella M, Snyder SA. (2004)
Chemistry and biology of diazonamide a: First total synthesis and confirmation of the
true structure. J. Am. Chem. Soc. 126(40): 12888-96.
1632. Nicolaou KC, Gray DLF. (2004) Total synthesis of hybocarpone and analogues
thereof. A facile dimerization of naphthazarins to pentacyclic systems. J. Am. Chem.
Soc. 126(2): 607-12.
1633. Nicolaou KC, Gray DLF, Tae JS. (2004) Total synthesis of hamigerans and
analogues thereof. Photochemical generation and diels-alder trapping of hydroxy-oquinodimethanes.
J. Am. Chem. Soc. 126(2): 613-27.
1634. Nicolaou KC, Hao JL, Reddy MV, Rao PB, Rassias G, Snyder SA, Huang XH,
Chen DYK, Brenzovich WE, Giuseppone N, Giannakakou P, O'Brate A. (2004)

Chemistry and biology of diazonamide a: Second total synthesis and biological
investigations. J. Am. Chem. Soc. 126(40): 12897-906.
1635. Nicolaou KC, Koftis TV, Vyskocil S, Petrovic G, Ling TT, Yamada YMA, Tang
WJ, Frederick MO. (2004) Structural revision and total synthesis of azaspiracid-1, part
2: Definition of the abcd domain and total synthesis. Angew. Chem.-Int. Edit. 43(33):
4318-24.
1636. Nicolaou KC, Mathison CJN, Montagnon T. (2004) O-iodoxybenzoic acid (ibx) as
a viable reagent in the manipulation of nitrogen- and sulfur-containing substrates:
Scope, generality, and mechanism of ibx-mediated amine oxidations and dithiane
deprotections. J. Am. Chem. Soc. 126(16): 5192-201.
1637. Nicolaou KC, Safina BS, Zak M, Estrada AA, Lee SH. (2004) Total synthesis of
thiostrepton, part 1: Construction of the dehydropiperidine/thiazoline-containing
macrocycle. Angew. Chem.-Int. Edit. 43(38): 5087-92.
1638. Nicolaou KC, Sasmal PK, Xu H. (2004) Biomimetically inspired total synthesis
and structure activity relationships of 1-o-methyllateriflorone. 6 pi electrocyclizations in
organic synthesis. J. Am. Chem. Soc. 126(17): 5493-501.
1639. Nicolaou KC, Snyder SA. (2004) The essence of total synthesis. Proc. Natl.
Acad. Sci. U. S. A. 101(33): 11929-36.
1640. Nicolaou KC, Snyder SA, Giuseppone N, Huang XH, Bella M, Reddy MV, Rao
PB, Koumbis AE, Giannakakou P, O'Brate A. (2004) Studies toward diazonamide a:
Development of a hetero-pinacol macrocyclization cascade for the construction of the
bis-macrocyclic framework of the originally proposed structure. J. Am. Chem. Soc.
126(32): 10174-82.
1641. Nicolaou KC, Snyder SA, Huang XH, Simonsen KB, Koumbis AE, Bigot A. (2004)
Studies toward diazonamide a: Initial synthetic forays directed toward the originally
proposed structure. J. Am. Chem. Soc. 126(32): 10162-73.
1642. Nicolaou KC, Snyder SA, Longbottom DA, Nalbandian AZ, Huang XH. (2004)
New uses for the burgess reagent in chemical synthesis: Methods for the facile and
stereoselective formation of sulfamidates, glycosylamines, and sulfamides. Chem.-Eur.
J. 10(22): 5581-606.
1643. Nicolaou KC, Snyder SA, Nalbandian AZ, Longbottom DA. (2004) A new method
for the stereoselective synthesis of alpha- and beta-glycosylamines using the burgess
reagent. J. Am. Chem. Soc. 126(20): 6234-5.
1644. Nicolaou KC, Vyskocil S, Koftis TV, Yamada YMA, Ling TT, Chen DYK, Tang
WJ, Petrovic G, Frederick MO, Li YW, Satake M. (2004) Structural revision and total
synthesis of azaspiracid-1, part 1: Intelligence gathering and tentative proposal. Angew.
Chem.-Int. Edit. 43(33): 4312-8.
1645. Nicolaou KC, Zak M, Safina BS, Lee SH, Estrada AA. (2004) Total synthesis of
thiostrepton, part 2: Construction of the quinaldic acid macrocycle and final stages of the
synthesis. Angew. Chem.-Int. Edit. 43(38): 5092-7.
1646. Notz W, Watanabe S, Chowdari NS, Zhong GF, Betancort JM, Tanaka F, Barbas
CF. (2004) The scope of the direct proline-catalyzed asymmetric addition of ketones to
imines. Adv. Synth. Catal. 346(9-10): 1131-40.
1647. Nyffeler PT, Boyle NA, Eltepu L, Wong CH, Eschenmoser A, Lerner RA,

Wentworth P. (2004) Dihydrogen trioxide (hoooh) is generated during the thermal
reaction between hydrogen peroxide and ozone. Angew. Chem.-Int. Edit. 43(35): 4656-
9.
1648. O'Neill BM, Hanway D, Winzeler EA, Romesberg FE. (2004) Coordinated
functions of wss1, psy2 and tof1 in the DNA damage response. Nucleic Acids Res.
32(22): 6519-30.
1649. Ogden CA, Rich ME, Schork NJ, Paulus MP, Geyer MA, Lohr JB, Kuczenski R,
Niculescu AB. (2004) Candidate genes, pathways and mechanisms for bipolar (manicdepressive)
and related disorders: An expanded convergent functional genomics
approach. Mol. Psychiatr. 9(11): 1007-29.
1650. Ortega-Gutierrez S, Hawkins EG, Viso A, Lopez-Rodriguez ML, Cravatt BF.
(2004) Comparison of anandamide transport in faah wild-type and knockout neurons:
Evidence for contributions by both faah and the cb1 receptor to anandamide uptake.
Biochemistry. 43(25): 8184-90.
1651. Otani A, Dorrell MI, Kinder K, Moreno SK, Nusinowitz S, Banin E, Heckenlively J,
Friedlander M. (2004) Rescue of retinal degeneration by intravitreally injected adult
bone marrow-derived lineage-negative hematopoietic stem cells. J. Clin. Invest. 114(6):
765-74.
1652. Page LJ, Huff ME, Kelly JW, Balch WE. (2004) Ca2+ binding protects against
gelsolin amyloidosis. Biochem. Biophys. Res. Commun. 322(4): 1105-10.
1653. Palmer LC, Rebek J. (2004) The ins and outs of molecular encapsulation. Org.
Biomol. Chem. 2(21): 3051-9.
1654. Park SY, Beel BD, Simon MI, Bilwes AM, Crane BR. (2004) In different
organisms, the mode of interaction between two signaling proteins is not necessarily
conserved. Proc. Natl. Acad. Sci. U. S. A. 101(32): 11646-51.
1655. Park SY, Chao XJ, Gonzalez-Bonet G, Beel BD, Bilwes AM, Crane BR. (2004)
Structure and function of an unusual family of protein phosphatases: The bacterial
chemotaxis proteins chec and chex. Mol. Cell. 16(4): 563-74.
1656. Park SY, Quezada CM, Bilwes AM, Crane BR. (2004) Subunit exchange by chea
histidine kinases from the mesophile escherichia coli and the thermophile thermotoga
maritima. Biochemistry. 43(8): 2228-40.
1657. Parrish JP, Trzupek JD, Hughes TV, Hwang I, Boger DL. (2004) Synthesis and
evaluation of n-aryl and n-alkenyl cbi derivatives. Bioorg. Med. Chem. 12(22): 5845-56.
1658. Peterson KS, Huang JF, Zhu J, D'Agati V, Liu XJ, Miller N, Erlander MG, Jackson
MR, Winchester RJ. (2004) Characterization of heterogeneity in the molecular
pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli.
J. Clin. Invest. 113(12): 1722-33.
1659. Phillips GR, Anderson TR, Florens L, Gudas C, Magda G, Yates JR, Colman DR.
(2004) Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of
central nervous system synapses and dendritic spines. J. Neurosci. Res. 78(1): 38-48.
1660. Phoon CW, Somanadhan B, Heng SCH, Ngo A, Ng SB, Butler MS, Buss AD, Sim
MM. (2004) Isolation and total synthesis of gymnastatin n, a polo-like kinase 1 active
constituent from the fungus arachniotus punctatus. Tetrahedron. 60(50): 11619-28.
1661. Pletcher MT, McClurg P, Batalov S, Su AI, Barnes SW, Lagler E, Korstanje R,

Wang XS, Nusskern D, Bogue MA, Mural RJ, Paigen B, Wiltshire T. (2004) Use of a
dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS.
Biol. 2(12): 2159-69.
1662. Ponti A, Machacek M, Gupton SL, Waterman-Storer CM, Danuser G. (2004) Two
distinct actin networks drive the protrusion of migrating cells. Science. 305(5691): 1782-
6.
1663. Purkey HE, Palaninathan SK, Kent KC, Smith C, Safe SH, Sacchettini JC, Kelly
JW. (2004) Hydroxylated polychlorinated biphenyls selectively bind transthyretin in
blood and inhibit amyloidogenesis: Rationalizing rodent pcb toxicity. Chem. Biol. 11(12):
1719-28.
1664. Putnam CD, Pennaneach V, Kolodner RD. (2004) Chromosome healing through
terminal deletions generated by de novo telomere additions in saccharomyces
cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 101(36): 13262-7.
1665. Qiu JZ, Liu R, Chapados BR, Sherman M, Tainer JA, Shen BH. (2004)
Interaction interface of human flap endonuclease-1 with its DNA substrates. J. Biol.
Chem. 279(23): 24394-402.
1666. Quezada CM, Gradinaru C, Simon MI, Bilwes AM, Crane BR. (2004) Helical
shifts generate two distinct conformers in the atomic resolution structure of the chea
phosphotransferase domain from thermotoga maritima. J. Mol. Biol. 341(5): 1283-94.
1667. Reixach N, Deechongkit S, Jiang X, Kelly JW, Buxbaum JN. (2004) Tissue
damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the
major cytotoxic species in tissue culture. Proc. Natl. Acad. Sci. U. S. A. 101(9): 2817-22.
1668. Rhee IK, Appels N, Hofte B, Karabatak B, Erkelens C, Stark LM, Flippin LA,
Verpoorte R. (2004) Isolation of the acetylcholinesterase inhibitor ungeremine from
nerine bowdenii by preparative hplc coupled on-line to a flow assay system. Biol.
Pharm. Bull. 27(11): 1804-9.
1669. Roberts VA, Case DA, Tsui V. (2004) Predicting interactions of winged-helix
transcription factors with DNA. Proteins. 57(1): 172-87.
1670. Roger B, Al-Bassam J, Dehmelt L, Milligan RA, Halpain S. (2004) Map2c, but not
tau, binds via its microtubule binding and bundles f-actin domain. Curr. Biol. 14(5): 363-
71.
1671. Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB,
FitzGerald GA. (2004) Bmal1 and clock, two essential components of the circadian
clock, are involved in glucose homeostasis. PLoS. Biol. 2(11): 1893-9.
1672. Saghatelian A, Jessani N, Joseph A, Humphrey M, Cravatt BF. (2004) Activitybased
probes for the proteomic profiling of metalloproteases. Proc. Natl. Acad. Sci. U.
S. A. 101(27): 10000-5.
1673. Saghatelian A, Trauger SA, Want EJ, Hawkins EG, Siuzdak G, Cravatt BF.
(2004) Assignment of endogenous substrates to enzymes by global metabolite profiling.
Biochemistry. 43(45): 14332-9.
1674. Sagle LB, Zimmermann J, Dawson PE, Romesberg FE. (2004) A high-resolution
probe of protein folding. J. Am. Chem. Soc. 126(11): 3384-5.
1675. Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS.
(2004) Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt

esults in the induction of hypoxic stress. J. Biol. Chem. 279(39): 40337-44.
1676. Sam-Yellowe TY, Florens L, Johnson JR, Wang TM, Drazba JA, Le Roch KG,
Zhou YY, Batalov S, Carucci DJ, Winzeler EA, Yates JR. (2004) A plasmodium gene
family encoding maurer's cleft membrane proteins: Structural properties and expression
profiling. Genome Res. 14(6): 1052-9.
1677. Sanchez-Quesada J, Saghatelian A, Cheley S, Bayley H, Ghadiri MR. (2004)
Single DNA rotaxanes of a transmembrane pore protein. Angew. Chem.-Int. Edit.
43(23): 3063-7.
1678. Sandilands A, Wang X, Hutcheson AM, James J, Prescott AR, Wegener A,
Pekny M, Gong XH, Quinlan RA. (2004) Bfsp2 mutation found in mouse 129 strains
causes the loss of cp49 and induces vimentin-dependent changes in the lens fibre cell
cytoskeleton. Exp. Eye Res. 78(1): 109-23.
1679. Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, Naik KA,
Fitzgerald GA, Kay SA, Hogenesch JB. (2004) A functional genomics strategy reveals
rora as a component of the mammalian circadian clock. Neuron. 43(4): 527-37.
1680. Schnell JR, Dyson HJ, Wright PE. (2004) Structure, dynamics, and catalytic
function of dihydrofolate reductase. Annu. Rev. Biophys. Biomol. Struct. 33: 119-40.
1681. Schnell JR, Dyson HJ, Wright PE. (2004) Effect of cofactor binding and loop
conformation on side chain methyl dynamics in dihydrofolate reductase. Biochemistry.
43(2): 374-83.
1682. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman
E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M. (2004) The creb
coactivator torc2 functions as a calcium- and camp-sensitive coincidence detector. Cell.
119(1): 61-74.
1683. Seebach D, Namoto K, Mahajan YR, Bindschadler P, Sustmann R, Kirsch M,
Ryder NS, Weiss M, Sauer M, Roth C, Werner S, Beer HD, Munding C, Walde P, Voser
M. (2004) Chemical and biological investigations of beta-oligoarginines. Chem.
Biodivers. 1(1): 65-97.
1684. Shentu XC, Yao K, Xu W, Zheng S, Hu SN, Gong XH. (2004) Special
fasciculiform cataract caused by a mutation in the gamma d-crystallin gene. Mol. Vis.
10(28-30): 233-9.
1685. Sieber SA, Mondala TS, Head SR, Cravatt BF. (2004) Microarray platform for
profiling enzyme activities in complex proteomes. J. Am. Chem. Soc. 126(48): 15640-1.
1686. Sinha SC, Li LS, Watanabe S, Kaltgrad E, Tanaka F, Rader C, Lerner RA,
Barbas CF. (2004) Aldolase antibody activation of prodrugs of potent aldehydecontaining
cytotoxics for selective chemotherapy. Chem.-Eur. J. 10(21): 5467-72.
1687. Speers AE, Cravatt BF. (2004) Chemical strategies for activity-based proteomics.
Chembiochem. 5(1): 41-7.
1688. Speers AE, Cravatt BF. (2004) Profiling enzyme activities in vivo using click
chemistry methods. Chem. Biol. 11(4): 535-46.
1689. Spence MM, Ruiz EJ, Rubin SM, Lowery TJ, Winssinger N, Schultz PG,
Wemmer DE, Pines A. (2004) Development of a functionalized xenon biosensor. J. Am.
Chem. Soc. 126(46): 15287-94.
1690. Srikanth GSC, Castle SL. (2004) Synthesis of beta-substituted beta-amino acids

via lewis acid promoted radical conjugate additions to alpha,beta-unsaturated alphanitro
esters and amides. Org. Lett. 6(3): 449-52.
1691. Stark LM, Pekari K, Sorensen EJ. (2004) A nucleophile-catalyzed
cycloisomerization permits a concise synthesis of (+)-harziphilone. Proc. Natl. Acad.
Sci. U. S. A. 101(33): 12064-6.
1692. Stevens TA, Iacovoni JS, Edelman DB, Meech R. (2004) Identification of novel
binding elements and gene targets for the homeodomain protein barx2. J. Biol. Chem.
279(15): 14520-30.
1693. Strable E, Johnson JE, Finn MG. (2004) Natural nanochemical building blocks:
Icosahedral virus particles organized by attached oligonucleotides. Nano Lett. 4(8):
1385-9.
1694. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R,
Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB. (2004) A gene atlas of
the mouse and human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. U. S. A.
101(16): 6062-7.
1695. Swairjo MA, Otero FJ, Yang XL, Lovato MA, Skene RJ, McRee DE, de Pouplana
LR, Schimmel P. (2004) Alanyl-trna synthetase crystal structure and design for
acceptor-stem recognition. Mol. Cell. 13(6): 829-41.
1696. Tang YT, Eintage P, Funk WD, Hu TH, Arterburn M, Park EEJ, Rupp F. (2004)
Tafa: A novel secreted family with conserved cysteine residues and restricted
expression in the brain. Genomics. 83(4): 727-34.
1697. Tao HC, Hwang IK, Boger DL. (2004) Multidrug resistance reversal activity of
permethyl ningalin b amide derivatives. Bioorg. Med. Chem. Lett. 14(24): 5979-81.
1698. Tarby CM. (2004) Recent advances in the development of next generation nonnucleoside
reverse transcriptase inhibitors. Curr. Top. Med. Chem. 4(10): 1045-57.
1699. Thorpe IF, Brooks CL. (2004) The coupling of structural fluctuations to hydride
transfer in dihydrofolate reductase. Proteins. 57(3): 444-57.
1700. Thurmond RL, Beavers MP, Cai H, Meduna SP, Gustin DJ, Sun SQ, Almond HJ,
Karlsson L, Edwards JP. (2004) Nonpeptidic, noncovalent inhibitors of the cysteine
protease cathepsin s. J. Med. Chem. 47(20): 4799-801.
1701. Thurmond RL, Sun SQ, Sehon CA, Baker SM, Cai H, Gu Y, Jiang W, Riley JP,
Williams KN, Edwards JP, Karlsson L. (2004) Identification of a potent and selective
noncovalent cathepsin s inhibitor. J. Pharmacol. Exp. Ther. 308(1): 268-76.
1702. Tichenor MS, Kastrinsky DB, Boger DL. (2004) Total synthesis, structure
revision, and absolute configuration of (+)-yatakemycin. J. Am. Chem. Soc. 126(27):
8396-8.
1703. Trauger SA, Wu E, Bark SJ, Nemerow GR, Siuzdak G. (2004) The identification
of an adenovirus receptor by using affinity capture and mass spectrometry.
Chembiochem. 5(8): 1095-9.
1704. Tse WC, Boger DL. (2004) A fluorescent intercalator displacement assay for
establishing DNA binding selectivity and affinity. Accounts Chem. Res. 37(1): 61-9.
1705. Tse WC, Boger DL. (2004) Sequence-selective DNA recognition: Natural
products and nature's lessons. Chem. Biol. 11(12): 1607-17.
1706. Vallotton P, Gupton SL, Waterman-Storer CM, Danuser G. (2004) Simultaneous

mapping of filamentous actin flow and turnover in migrating cells by quantitative
fluorescent speckle microscopy. Proc. Natl. Acad. Sci. U. S. A. 101(26): 9660-5.
1707. Vevodova J, Graham RM, Raux E, Schubert HL, Roper DI, Brindley AA, Scott AI,
Roessner CA, Stamford NPJ, Stroupe ME, Getzoff ED, Warren MJ, Wilson KS. (2004)
Structure/function studies on a s-adenosyl-(l)-methionine-dependent uroporphyrinogen
iii c methyltransferase (sumt), a key regulatory enzyme of tetrapyrrole biosynthesis. J.
Mol. Biol. 344(2): 419-33.
1708. Vieth M, Siegel MG, Higgs RE, Watson IA, Robertson DH, Savin KA, Durst GL,
Hipskind PA. (2004) Characteristic physical properties and structural fragments of
marketed oral drugs. J. Med. Chem. 47(1): 224-32.
1709. Vos TJ, Caracoti A, Che JL, Dai M, Farrer CA, Forsyth NE, Drabic SV, Horlick
RA, Lamppu D, Yowe DL, Balani S, Li P, Zeng H, Joseph I, Rodriguez LE, Maguire MP,
Patane MA, Claiborne CF. (2004) Identification of 2-{2-[2-(5-bromo-2-methoxyphenyl)ethyl]-3-fluoro-phenyl}-4,5-dihydro-1h
-imidazole (ml00253764), a small molecule
melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in
a mouse model. J. Med. Chem. 47(7): 1602-4.
1710. Walker JR, Su AI, Self DW, Hogenesch JB, Lapp H, Maier R, Hoyer D, Bilbe G.
(2004) Applications of a rat multiple tissue gene expression data set. Genome Res.
14(4): 742-9.
1711. Wan W, Zhao G, Al-Saad K, Siems WF, Zhou ZS. (2004) Rapid screening for sadenosylmethionine-dependent
methylation products by enzyme-transferred isotope
patterns analysis. Rapid Commun. Mass Spectrom. 18(3): 319-24.
1712. Wang JF, Schnell JR, Chou JJ. (2004) Amantadine partition and localization in
phospholipid membrane: A solution nmr study. Biochem. Biophys. Res. Commun.
324(1): 212-7.
1713. Wang ZQ, Wei CC, Sharma M, Pant K, Crane BR, Stuehr DJ. (2004) A
conserved val to ile switch near the heme pocket of animal and bacterial nitric-oxide
synthases helps determine their distinct catalytic profiles. J. Biol. Chem. 279(18):
19018-25.
1714. Weber A, Ni JS, Ling KHJ, Acheampong A, Tang-Liu DDS, Burk R, Cravatt BF,
Woodward D. (2004) Formation of prostamides from anandamide in faah knockout mice
analyzed by hplc with tandem mass spectrometry. J. Lipid Res. 45(4): 757-63.
1715. Weissman JT, Ma JN, Essex A, Gao Y, Burstein ES. (2004) G-protein-coupled
receptor-mediated activation of rap gtpases: Characterization of a novel g alpha i
regulated pathway. Oncogene. 23(1): 241-9.
1716. Whitton JL, Slifka MK, Liu F, Nussbaum AK, Whitmire JK. (2004) The regulation
and maturation of antiviral immune responses. Adv. Virus Res. 63: 181-238.
1717. Winssinger N, Damoiseaux R, Tully DC, Geierstanger BH, Burdick K, Harris JL.
(2004) Pna-encoded protease substrate microarrays. Chem. Biol. 11(10): 1351-60.
1718. Wolan DW, Cheong CG, Greasley SE, Wilson IA. (2004) Structural insights into
the human and avian imp cyclohydrolase mechanism via crystal structures with the
bound xmp inhibitor. Biochemistry. 43(5): 1171-83.
1719. Wolkenberg SE, Wisnoski DD, Leister WH, Wang Y, Zhao ZJ, Lindsley CW.
(2004) Efficient synthesis of imidazoles from aldehydes and 1,2-diketones using

microwave irradiation. Org. Lett. 6(9): 1453-6.
1720. Wu CY, Jan JT, Ma SH, Kuo CJ, Juan HF, Cheng YSE, Hsu HH, Huang HC, Wu
D, Brik A, Liang FS, Liu RS, Fang JM, Chen ST, Liang PH, Wong CH. (2004) Small
molecules targeting severe acute respiratory syndrome human coronavirus. Proc. Natl.
Acad. Sci. U. S. A. 101(27): 10012-7.
1721. Wu E, Nemerow GR. (2004) Virus yoga: The role of flexibility in virus host cell
recognition. Trends Microbiol. 12(4): 162-9.
1722. Wu E, Trauger SA, Pache L, Mullen TM, Von Seggern DJ, Siuzdak G, Nemerow
GR. (2004) Membrane cofactor protein is a receptor for adenoviruses associated with
epidemic keratoconjunctivitis. J. Virol. 78(8): 3897-905.
1723. Wu GS, Vieth M. (2004) Sdocker: A method utilizing existing x-ray structures to
improve docking accuracy. J. Med. Chem. 47(12): 3142-8.
1724. Wu P, Feldman AK, Nugent AK, Hawker CJ, Scheel A, Voit B, Pyun J, Frechet
JMJ, Sharpless KB, Fokin VV. (2004) Efficiency and fidelity in a click-chemistry route to
triazole dendrimers by the copper(i)-catalyzed ligation of azides and alkynes. Angew.
Chem.-Int. Edit. 43(30): 3928-32.
1725. Wu TYH, Hassig C, Wu YQ, Ding S, Schultz PG. (2004) Design, synthesis, and
activity of hdac inhibitors with a n-formyl hydroxylamine head group. Bioorg. Med.
Chem. Lett. 14(2): 449-53.
1726. Wu X, Ding S, Ding G, Gray NS, Schultz PG. (2004) Small molecules that induce
cardiomyogenesis in embryonic stem cells. J. Am. Chem. Soc. 126(6): 1590-1.
1727. Wu X, Walker J, Zhang J, Ding S, Schultz PG. (2004) Purmorphamine induces
osteogenesis by activation of the hedgehog signaling pathway. Chem. Biol. 11(9): 1229-
38.
1728. Xie JM, Wang L, Wu N, Brock A, Spraggon G, Schultz PG. (2004) The sitespecific
incorporation of p-iodo-l-phenylalanine into proteins for structure determination.
Nat. Biotechnol. 22(10): 1297-301.
1729. Xu R, Hanson SR, Zhang ZW, Yang YY, Schultz PG, Wong CH. (2004) Sitespecific
incorporation of the mucin-type n-acetylgalactosamine-alpha-o-threonine into
protein in escherichia coli. J. Am. Chem. Soc. 126(48): 15654-5.
1730. Xu Y, Yamamoto N, Janda KD. (2004) Catalytic antibodies: Hapten design
strategies and screening methods. Bioorg. Med. Chem. 12(20): 5247-68.
1731. Yadav D, Judkowski V, Flodstrom-Tullberg M, Sterling L, Redmond WL, Sherman
L, Sarvetnick N. (2004) B7-2 (cd86) controls the priming of autoreactive cd4 t cell
response against pancreatic islets. J. Immunol. 173(6): 3631-9.
1732. Yao SL, Sgarbi PWM, Marby KA, Rabuka D, O'Hare SM, Cheng ML, Bairi M, Hu
CY, Hwang SB, Hwang CK, Ichikawa Y, Sears P, Sucheck SJ. (2004) Glycooptimization
of aminoglycosides: New aminoglycosides as novel anti-infective agents.
Bioorg. Med. Chem. Lett. 14(14): 3733-8.
1733. You SL, Deechongkit S, Kelly JW. (2004) Solid-phase synthesis and
stereochemical assignments of tenuecyclamides a-d employing heterocyclic amino
acids derived from commercially available fmoc alpha-amino acids. Org. Lett. 6(15):
2627-30.
1734. Yue EW, DiMeo SV, Higley CA, Markwalder JA, Burton CR, Benfield PA,

Grafstrom RH, Cox S, Muckelbauer JK, Smallwood AM, Chen HY, Chang CH, Trainor
GL, Seitz SP. (2004) Synthesis and evaluation of indenopyrazoles as cyclin-dependent
kinase inhibitors. Part 4: Heterocycles at c3. Bioorg. Med. Chem. Lett. 14(2): 343-6.
1735. Zhang Q, Dwyer TJ, Tsui V, Case DA, Cho JH, Dervan PB, Wemmer DE. (2004)
Nmr structure of a cyclic polyamide-DNA complex. J. Am. Chem. Soc. 126(25): 7958-
66.
1736. Zhang QH, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG,
Eschenmoser A, Wentworth P, Lerner RA, Kelly JW. (2004) Metabolite-initiated protein
misfolding may trigger alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 101(14):
4752-7.
1737. Zhang ZW, Gildersleeve J, Yang YY, Xu R, Loo JA, Uryu S, Wong CH, Schultz
PG. (2004) A new strategy for the synthesis of glycoproteins. Science. 303(5656): 371-
3.
1738. Zhao M, Boja ES, Hoodbhoy T, Nawrocki J, Kaufman JB, Kresge N, Ghirlando R,
Shiloach J, Pannell L, Levine RL, Fales HM, Dean J. (2004) Mass spectrometry analysis
of recombinant human zp3 expressed in glycosylation-deficient cho cells. Biochemistry.
43(38): 12090-104.
1739. Zhao ZJ, Wisnoski DD, Wolkenberg SE, Leister WH, Wang Y, Lindsley CW.
(2004) General microwave-assisted protocols for the expedient synthesis of
quinoxalines and heterocyclic pyrazines. Tetrahedron Lett. 45(25): 4873-6.
1740. Zheng LX, Liu J, Batalov S, Zhou DM, Orth A, Ding S, Schultz PG. (2004) An
approach to genomewide screens of expressed small interfering rnas in mammalian
cells. Proc. Natl. Acad. Sci. U. S. A. 101(1): 135-40.
1741. Zhong GF. (2004) Tandem aminoxylation-allylation reactions: A rapid,
asymmetric conversion of aldehydes to mono-substituted 1,2-diols. Chem. Commun.
(5): 606-7.
1742. Zhong GF, Fan JH, Barbas CF. (2004) Amino alcohol catalyzed direct
asymmetric aldol reactions: Enantioselective synthesis of anti-alpha-fluoro-beta-hydroxy
ketones. Tetrahedron Lett. 45(29): 5681-4.
1743. Zhong GF, Yu YP. (2004) Enantioselective synthesis of allylic alcohols by the
sequential aminoxylation-olefination reactions of aldehydes under ambient conditions.
Org. Lett. 6(10): 1637-9.
1744. Zhu XY, Chu LY, Chueh BH, Shen MW, Hazarika B, Phadke N, Takayama S.
(2004) Arrays of horizontally-oriented mini-reservoirs generate steady microfluidic flows
for continuous perfusion cell culture and gradient generation. Analyst. 129(11): 1026-31.
1745. Zhu XY, Tanaka F, Hu YF, Heine A, Fuller R, Zhong GF, Olson AJ, Lerner RA,
Barbas CF, Wilson IA. (2004) The origin of enantioselectivity in aldolase antibodies:
Crystal structure, site-directed mutagenesis, and computational analysis. J. Mol. Biol.
343(5): 1269-80.
1746. Zwick MB, Komori HK, Stanfield RL, Church S, Wang M, Parren P, Kunert R,
Katinger H, Wilson IA, Burton DR. (2004) The long third complementarity-determining
region of the heavy chain is important in the activity of the broadly neutralizing antihuman
immunodeficiency virus type 1 antibody 2f5. J. Virol. 78(6): 3155-61.
1747. Zwick MB, Saphire EO, Burton DR. (2004) Gp41: Hiv's shy protein. Nat. Med.

10(2): 133-4.
1748. Ait-Azzouzene D, Verkoczy L, Peters J, Gavin A, Skog P, Vela JL, Nemazee D.
(2005) An immunoglobulin c kappa-reactive single chain antibody fusion protein induces
tolerance through receptor editing in a normal polyclonal immune system. J. Exp. Med.
201(5): 817-28.
1749. Alexander JP, Cravatt BF. (2005) Mechanism of carbamate inactivation of faah:
Implications for the design of covalent inhibitors and in vivo functional probes for
enzymes. Chem. Biol. 12(11): 1179-87.
1750. Andrews D, Butler JS, Al-Bassam J, Joss L, Winn-Stapley DA, Casjens S,
Cingolani G. (2005) Bacteriophage p22 tail accessory factor gp26 is a long triplestranded
coiled-coil. J. Biol. Chem. 280(7): 5929-33.
1751. Arndt JW, Gu J, Jaroszewski L, Schwarzenbacher R, Hanson MA, Lebeda FJ,
Stevens RC. (2005) The structure of the neurotoxin-associated protein ha33/a from
clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin
complex. J. Mol. Biol. 346(4): 1083-93.
1752. Arnold LA, Estebanez-Perpina E, Togashi M, Jouravel N, Shelat A, McReynolds
AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. (2005) Discovery of
small molecule inhibitors of the interaction of the thyroid hormone receptor with
transcriptional coregulators. J. Biol. Chem. 280(52): 43048-55.
1753. Babon JJ, Yao SG, DeSouza DP, Harrison CF, Fabri LJ, Liepinsh E, Scrofani SD,
Baca M, Norton RS. (2005) Secondary structure assignment of mouse socs3 by nmr
defines the domain boundaries and identifies an unstructured insertion in the sh2
domain. Febs J. 272(23): 6120-30.
1754. Baran PS, Guerrero CA, Ambhaikar NB, Hafensteiner BD. (2005) Short,
enantioselective total synthesis of stephacidin a. Angew. Chem.-Int. Edit. 44(4): 606-9.
1755. Baran PS, Guerrero CA, Hafensteiner BD, Ambhaikar NB. (2005) Total synthesis
of avrainvillamide (cj-17,665) and stephacidin b. Angew. Chem.-Int. Edit. 44(25): 3892-
5.
1756. Baran PS, Richter JM. (2005) Enantioselective total syntheses of
welwitindolinone a and fischerindoles i and g. J. Am. Chem. Soc. 127(44): 15394-6.
1757. Baran PS, Richter JM, Lin DW. (2005) Direct coupling of pyrroles with carbonyl
compounds: Short enantioselective synthesis of (s)-ketorolac. Angew. Chem.-Int. Edit.
44(4): 609-12.
1758. Baran PS, Shenvi RA, Mitsos CA. (2005) A remarkable ring contraction en route
to the chartelline alkaloids. Angew. Chem.-Int. Edit. 44(24): 3714-7.
1759. Barluenga S, Moulin E, Lopez P, Winssinger N. (2005) Solution- and solid-phase
synthesis of radicicol (monorden) and pochonin c. Chem.-Eur. J. 11(17): 4935-52.
1760. Barnes D, Franklin S, Schultz J, Henry R, Brown E, Coragliotti A, Mayfield SP.
(2005) Contribution of 5 '- and 3 '-untranslated regions of plastid mrnas to the
expression of chlamydomonas reinhardtii chloroplast genes. Mol. Genet. Genomics.
274(6): 625-36.
1761. Baxter IR, Young JC, Armstrong G, Foster N, Bogenschutz N, Cordova T, Peer
WA, Hazen SP, Murphy AS, Harper JF. (2005) A plasma membrane h+-atpase is
required for the formation of proanthocyanidins in the seed coat endothelium of

arabidopsis thaliana. Proc. Natl. Acad. Sci. U. S. A. 102(7): 2649-54.
1762. Beck ZQ, Aldrich CC, Magarvey NA, Georg GI, Sherman DH. (2005)
Chemoenzymatic synthesis of cryptophycin/arenastatin natural products. Biochemistry.
44(41): 13457-66.
1763. Belec L, Blankenship JW, Lubell WD. (2005) Examination of structural
characteristics of the potent oxytocin antagonists (dpen(1) pen(6))-ot and (dpen(1)
pen(6), 5-(t)bupro(7))-ot by nmr, raman, cd spectroscopy and molecular modeling. J.
Pept. Sci. 11(7): 365-78.
1764. Beltran AC, Dawson PE, Gottesfeld JM. (2005) Role of DNA sequence in the
binding specificity of synthetic basic-helix-loop-helix domains. Chembiochem. 6(1): 104-
13.
1765. Beniash E, Hartgerink JD, Storrie H, Stendahl JC, Stupp SI. (2005) Selfassembling
peptide amphiphile nanofiber matrices for cell entrapment. Acta Biomater.
1(4): 387-97.
1766. Bertsch B, Ogden CA, Sidhu K, Le-Niculescu H, Kuczenski R, Niculescu AB.
(2005) Convergent functional genomics: A bayesian candidate gene identification
approach for complex disorders. Methods. 37(3): 274-9.
1767. Boger DL, Miyauchi H, Du W, Hardouin C, Fecik RA, Cheng H, Hwang I, Hedrick
MP, Leung D, Acevedo O, Guimaraes CRW, Jorgensen WL, Cravatt BF. (2005)
Discovery of a potent, selective, and efficacious class of reversible alphaketoheterocycle
inhibitors of fatty acid amide hydrolase effective as analgesics. J. Med.
Chem. 48(6): 1849-56.
1768. Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JR, Guenther MG,
Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA.
(2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell.
122(6): 947-56.
1769. Brogan AP, Dickerson TJ, Boldt GE, Janda KD. (2005) Altered retinoid
homeostasis catalyzed by a nicotine metabolite: Implications in macular
degenerationand and normal development. Proc. Natl. Acad. Sci. U. S. A. 102(30):
10433-8.
1770. Brunel FM, Dawson PE. (2005) Synthesis of constrained helical peptides by
thioether ligation: Application to analogs of gp41. Chem. Commun. (20): 2552-4.
1771. Buddha MR, Crane BR. (2005) Structures of tryptophanyl-trna synthetase ii from
deinococcus radiodurans bound to atp and tryptophan - insight into subunit cooperativity
and domain motions linked to catalysis. J. Biol. Chem. 280(36): 31965-73.
1772. Buddha MR, Crane BR. (2005) Structure and activity of an aminoacyl-trna
synthetase that charges trna with nitro-tryptophan. Nat. Struct. Mol. Biol. 12(3): 274-5.
1773. Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI,
Vellenga E, Wang JT, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW,
Cooke MP, de Haan G. (2005) Uncovering regulatory pathways that affect
hematopoietic stem cell function using 'genetical genomics'. Nature Genet. 37(3): 225-
32.
1774. Calarese DA, Lee HK, Huang CY, Best MD, Astronomo RD, Stanfield RL,
Katinger H, Burton DR, Wong CH, Wilson IA. (2005) Dissection of the carbohydrate

specificity of the broadly neutralizing-anti-hiv-1 antibody 2g12. Proc. Natl. Acad. Sci. U.
S. A. 102(38): 13372-7.
1775. Capps KJ, Humiston J, Dominique R, Hwang I, Boger DL. (2005) Discovery of
aicar tfase inhibitors that disrupt requisite enzyme dimerization. Bioorg. Med. Chem.
Lett. 15(11): 2840-4.
1776. Carlson A, Berkowitz JM, Browning D, Slamon DJ, Gasson JC, Yates KE. (2005)
Expression of c-fes protein isoforms correlates with differentiation in myeloid leukemias.
DNA Cell Biol. 24(5): 311-6.
1777. Carnahan RH, Feoktistova A, Ren L, Niessen S, Yates JR, Gould KL. (2005)
Dim1p is required for efficient splicing and export of mrna encoding lid1p, a component
of the fission yeast anaphase-promoting complex. Eukaryot. Cell. 4(3): 577-87.
1778. Carrera MRA, Trigo JM, Wirsching P, Roberts AJ, Janda KD. (2005) Evaluation
of the anticocaine monoclonal antibody gnc92h2 as an immunotherapy for cocaine
overdose. Pharmacol. Biochem. Behav. 81(4): 709-14.
1779. Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR.
(2005) Dual modes of rna-silencing suppression by flock house virus protein b2. Nat.
Struct. Mol. Biol. 12(11): 952-7.
1780. Chen M, Tao Y, Lim J, Shaw A, Chory J. (2005) Regulation of phytochrome b
nuclear localization through light-dependent unmasking of nuclear-localization signals.
Curr. Biol. 15(7): 637-42.
1781. Cheng H, Chong YH, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ,
Boger DL. (2005) Design, synthesis, and biological evaluation of 10-methanesulfonyldacthf,
10-methanesulfonyl-5-dacthf, and 10-methylthio-ddacthf as potent inhibitors of
gar tfase and the de novo purine biosynthetic pathway. Bioorg. Med. Chem. 13(10):
3577-85.
1782. Cheng H, Hwang I, Chong YH, Tavassoli A, Webb ME, Zhang Y, Wilson IA,
Benkovic SJ, Boger DL. (2005) Synthesis and biological evaluation of n-{4-[5-(2,4diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl)benzoyl}-lglutamic
acid as a potential inhibitor of gar tfase and the de novo purine biosynthetic
pathway. Bioorg. Med. Chem. 13(10): 3593-9.
1783. Choe J, Kelker MS, Wilson IA. (2005) Crystal structure of human toll-like receptor
3 (tlr3) ectodomain. Science. 309(5734): 581-5.
1784. Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
(2005) Synthesis and biological evaluation of alpha- and gamma-carboxamide
derivatives of 10-cf3co-ddacthf. Bioorg. Med. Chem. 13(10): 3587-92.
1785. Chou TC, Guan YB, Soenen DR, Danishefsky SJ, Boger DL. (2005) Potent
reversal of multidrug resistance by ningalins and its use in drug combinations against
human colon carcinoma xenograft in nude mice. Cancer Chemother. Pharmacol. 56(4):
379-90.
1786. Cirz RT, Chin JK, Andes DR, de Crecy-Lagard V, Craig WA, Romesberg FE.
(2005) Inhibition of mutation and combating the evolution of antibiotic resistance. PLoS.
Biol. 3(6): 1024-33.
1787. Clarke KM, La Clair JJ, Burkart MD. (2005) A three-component photoreversible
tag for thiols. J. Org. Chem. 70(9): 3709-11.

1788. Clarke KM, Mercer AC, La Clair JJ, Burkart MD. (2005) In vivo reporter labeling
of proteins via metabolic delivery of coenzyme a analogues. J. Am. Chem. Soc.
127(32): 11234-5.
1789. Combs AP, Yue EW, Bower M, Ala PJ, Wayland B, Douty B, Takvorian A, Polam
P, Wasserman Z, Zhu WY, Crawley ML, Pruitt J, Sparks R, Glass B, Modi D,
McLaughlin E, Bostrom L, Li M, Galya L, Blom K, Hillman M, Gonneville L, Reid BG,
Wei M, Becker-Pasha M, Klabe R, Huber R, Li YL, Hollis G, Burn TC, Wynn R, Liu P,
Metcalf B. (2005) Structure-based design and discovery of protein tyrosine phosphatase
inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
J. Med. Chem. 48(21): 6544-8.
1790. Cravatt BF. (2005) Live chemical reports from the cell surface. Chem. Biol. 12(9):
954-6.
1791. Cravatt BF. (2005) Kinase chemical genomics - a new rule for the exceptions.
Nat. Methods. 2(6): 411-2.
1792. Cravatt BF, Kodadek T. (2005) Proteomics and genomics - a chemo-centric view
of proteomics and genomics. Curr. Opin. Chem. Biol. 9(1): 1-3.
1793. Dang TX, Farah SJ, Gast A, Robertson C, Carragher B, Egelman E, Wilson-
Kubalek EM. (2005) Helical crystallization on lipid nanotubes: Streptavidin as a model
protein. J. Struct. Biol. 150(1): 90-9.
1794. Dang TX, Hotze EM, Rouiller I, Tweten RK, Wilson-Kubalek EM. (2005) Prepore
to pore transition of a cholesterol-dependent cytolysin visualized by electron
microscopy. J. Struct. Biol. 150(1): 100-8.
1795. Dang TX, Milligan RA, Tweten RK, Wilson-Kubalek EM. (2005) Helical
crystallization on nickel-lipid nanotubes: Perfringolysin o as a model protein. J. Struct.
Biol. 152(2): 129-39.
1796. Dann CE, Bruick RK. (2005) Dioxygenases as o-2-dependent regulators of the
hypoxic response pathway. Biochem. Biophys. Res. Commun. 338(1): 639-47.
1797. de Dios A, Shih C, de Uralde BL, Sanchez C, Del Prado M, Cabrejas LMM, Pleite
S, Blanco-Urgoiti J, Lorite MJ, Nevill CR, Bonjouklian R, York J, Vieth M, Wang Y,
Magnus N, Campbell RM, Anderson BD, McCann DJ, Giera DD, Lee PA, Schultz RM, Li
LC, Johnson LM, Wolos JA. (2005) Design of potent and selective 2aminobenzimidazole-based
p38 alpha map kinase inhibitors with excellent in vivo
efficacy. J. Med. Chem. 48(7): 2270-3.
1798. Debler EW, Ito S, Seebeck FP, Heine A, Hilvert D, Wilson IA. (2005) Structural
origins of efficient proton abstraction from carbon by a catalytic antibody. Proc. Natl.
Acad. Sci. U. S. A. 102(14): 4984-9.
1799. Deechongkit S, Powers ET, You SL, Kelly JW. (2005) Controlling the morphology
of cross beta-sheet assemblies by rational design. J. Am. Chem. Soc. 127(23): 8562-70.
1800. di Bernardo D, Thompson MJ, Gardner TS, Chobot SE, Eastwood EL, Wojtovich
AP, Elliott SJ, Schaus SE, Collins JJ. (2005) Chemogenomic profiling on a genomewide
scale using reverse-engineered gene networks. Nat. Biotechnol. 23(3): 377-83.
1801. Dias DP, Thaumaturgo C. (2005) Fracture toughness of geopolymeric concretes
reinforced with basalt fibers. Cem. Concr. Compos. 27(1): 49-54.
1802. Diaz DD, Lewis WG, Finn MG. (2005) Activation of urea as a leaving group in

substitution reactions of formamidine ureas. Chem. Lett. 34(1): 78-9.
1803. Diaz DD, Lewis WG, Finn MG. (2005) Acid-mediated amine exchange of n,ndimethylformamidines:
Preparation of electron-rich formamidines. Synlett. (14): 2214-8.
1804. Dickerson TJ, Beuscher AE, Hixon MS, Yamamoto N, Xu Y, Olson AJ, Janda
KD. (2005) Discovery of acetylcholinesterase peripheral anionic site ligands through
computational refinement of a directed library. Biochemistry. 44(45): 14845-53.
1805. Dickerson TJ, Janda KD. (2005) Recent advances for the treatment of cocaine
abuse: Central nervous system immunopharmacotherapy. Aaps Journal. 7(3): E579-
E86.
1806. Dickerson TJ, Kaufmann GF, Janda KD. (2005) Bacteriophage-mediated protein
delivery into the central nervous system and its application in immunopharmacotherapy.
Expert Opin. Biol. Ther. 5(6): 773-81.
1807. Ding S, Schultz PG. (2005) Small molecules and future regenerative medicine.
Curr. Top. Med. Chem. 5(4): 383-96.
1808. Dorn JF, Jaqaman K, Rines DR, Jelson GS, Sorger PK, Danuser G. (2005) Yeast
kinetochore microtubule dynamics analyzed by high-resolution three-dimensional
microscopy. Biophys. J. 89(4): 2835-54.
1809. Drahl C, Cravatt BF, Sorensen EJ. (2005) Protein-reactive natural products.
Angew. Chem.-Int. Edit. 44(36): 5788-809.
1810. Dreier B, Fuller RP, Segal DJ, Lund CV, Blancafort P, Huber A, Koksch B,
Barbas CF. (2005) Development of zinc finger domains for recognition of the 5 '-cnn-3 '
family DNA sequences and their use in the construction of artificial transcription factors.
J. Biol. Chem. 280(42): 35588-97.
1811. Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Diaz JF,
Giannakakou P, Ernest H. (2005) Cyclostreptin (fr182877), an antitumor tubulinpolymerizing
agent deficient in enhancing tubulin assembly despite its high affinity for
the taxoid site. Biochemistry. 44(34): 11525-38.
1812. Eubanks LM, Dickerson TJ, Janda KD. (2005) Vitamin b-2-mediated cellular
photoinhibition of botulinum neurotoxin a. FEBS Lett. 579(24): 5361-4.
1813. Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF. (2005) Target discovery in
small-molecule cell-based screens by in situ proteome reactivity profiling. Nat.
Biotechnol. 23(10): 1303-7.
1814. Fan GT, Pan YS, Lu KC, Cheng YP, Lin WC, Lin S, Lin CH, Wong CH, Fang JM,
Lin CC. (2005) Synthesis of alpha-galactosyl ceramide and the related glycolipids for
evaluation of their activities on mouse splenocytes. Tetrahedron. 61(7): 1855-62.
1815. Feldman AK, Colasson B, Sharpless KB, Fokin VV. (2005) The allylic azide
rearrangement: Achieving selectivity. J. Am. Chem. Soc. 127(39): 13444-5.
1816. Feuer R, Pagarigan RR, Harkins S, Liu F, Hunziker IP, Whitton JL. (2005)
Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal cns. J.
Neurosci. 25(9): 2434-44.
1817. Foss TR, Kelker MS, Wiseman RL, Wilson IA, Kelly JW. (2005) Kinetic
stabilization of the native state by protein engineering: Implications for inhibition of
transthyretin amyloidogenesis. J. Mol. Biol. 347(4): 841-54.
1818. Foss TR, Wiseman RL, Kelly JW. (2005) The pathway by which the tetrameric

protein transthyretin dissociates. Biochemistry. 44(47): 15525-33.
1819. Fridman M, Belakhov V, Lee LV, Liang FS, Wong CH, Baasov T. (2005) Dual
effect of synthetic aminoglycosides: Antibacterial activity against bacillus anthracis and
inhibition of anthrax lethal factor. Angew. Chem.-Int. Edit. 44(3): 447-52.
1820. Gearhart MD, Dickinson L, Ehley J, Melander C, Dervan PB, Wright PE,
Gottesfeld JM. (2005) Inhibition of DNA binding by human estrogen-related receptor 2
and estrogen receptor alpha with minor groove binding polyamides. Biochemistry.
44(11): 4196-203.
1821. Go EP, Apon JV, Luo G, Saghatelian A, Daniels RH, Sahi V, Dubrow R, Cravatt
BF, Vertes A, Siuzdak G. (2005) Desorption/ionization on silicon nanowires. Anal.
Chem. 77(6): 1641-6.
1822. Goetzinger WK, Cai H. (2005) Buffer system for the separation of neutral and
charged small molecules using micellar electrokinetic chromatography with mass
spectrometric detection. J. Chromatogr. A. 1079(1-2): 372-81.
1823. Green NS, Foss TR, Kelly JW. (2005) Genistein, a natural product from soy, is a
potent inhibitor of transthyretin amyloidosis. Proc. Natl. Acad. Sci. U. S. A. 102(41):
14545-50.
1824. Grey J, Dyck B, Rowbottom MW, Tamiya J, Vickers TD, Zhang MZ, Zhao LR,
Heise CE, Schwarz D, Saunders J, Goodfellow VS. (2005) Bis(aminopyrrolidine)derived
ureas (apus) as potent mch1 receptor antagonists. Bioorg. Med. Chem. Lett.
15(4): 999-1004.
1825. Gupton SL, Anderson KL, Kole TP, Fischer RS, Ponti A, Hitchcock-DeGregori
SE, Danuser G, Fowler VM, Wirtz D, Hanein D, Waterman-Storer CM. (2005) Cell
migration without a lamellipodium: Translation of actin dynamics into cell movement
mediated by tropornyosin. J. Cell Biol. 168(4): 619-31.
1826. Gurkan C, Lapp H, Alory C, Su AI, Hogenesch JB, Balch WE. (2005) Large-scale
profiling of rab gtpase trafficking networks: The membrome. Mol. Biol. Cell. 16(8): 3847-
64.
1827. Gustin DJ, Sehon CA, Wei JM, Cai H, Meduna SP, Khatuya H, Sun SQ, Gu Y,
Jiang W, Thurmond RL, Karlsson L, Edwards JP. (2005) Discovery and sar studies of a
novel series of noncovalent cathepsin s inhibitors. Bioorg. Med. Chem. Lett. 15(6):
1687-91.
1828. Guvench O, Brooks CL. (2005) Tryptophan side chain electrostatic interactions
determine edge-to-face vs parallel-displaced tryptophan side chain geometries in the
designed beta-hairpin "Trpzip2". J. Am. Chem. Soc. 127(13): 4668-74.
1829. Guvench O, Price DJ, Brooks CL. (2005) Receptor rigidity and ligand mobility in
trypsin-ligand complexes. Proteins. 58(2): 407-17.
1830. Haas CH, Biros SM, Rebek J. (2005) Binding properties of cavitands in aqueous
solution - the influence of charge on guest selectivity. Chem. Commun. (48): 6044-5.
1831. Hansen TV, Wu P, Fokin VV. (2005) One-pot copper(i)-catalyzed synthesis of
3,5-disubstituted isoxazoles. J. Org. Chem. 70(19): 7761-4.
1832. Harris JL, Winssinger N. (2005) Pna encoding (pna = peptide nucleic acid): From
solution-based libraries to organized microarrays. Chem.-Eur. J. 11(23): 6792-801.
1833. He LW, Srikanth GSC, Castle SL. (2005) Synthesis of beta-substituted alpha-

amino acids via lewis acid promoted enantioselective radical conjugate additions. J.
Org. Chem. 70(20): 8140-7.
1834. Henry AA, Romesberg FE. (2005) The evolution of DNA polymerases with novel
activities. Curr. Opin. Biotechnol. 16(4): 370-7.
1835. Hogestatt ED, Jonsson BAG, Ermund A, Andersson DA, Bjork H, Alexander JP,
Cravatt BF, Basbaum AI, Zygmunt PM. (2005) Conversion of acetaminophen to the
bioactive n-acylphenolamine am404 via fatty acid amide hydrolase-dependent
arachidonic acid conjugation in the nervous system. J. Biol. Chem. 280(36): 31405-12.
1836. Holmberg RC, Henry AA, Romesberg FE. (2005) Directed evolution of novel
polymerases. Biomol. Eng. 22(1-3): 39-49.
1837. Horne WS, Ashkenasy N, Ghadiri MR. (2005) Modulating charge transfer through
cyclic d,l-alpha-peptide self-assembly. Chem.-Eur. J. 11(4): 1137-44.
1838. Horne WS, Wiethoff CM, Cui CL, Wilcoxen KM, Amorin M, Ghadir MR, Nemerow
GR. (2005) Antiviral cyclic d,l-alpha-peptides: Targeting a general biochemical pathway
in virus infections. Bioorg. Med. Chem. 13(17): 5145-53.
1839. Hossain CF, Kim YP, Baerson SR, Zhang L, Bruick RK, Mohammed KA, Agarwal
AK, Nagle DG, Zhou YD. (2005) Saururus cernuus lignans - potent small molecule
inhibitors of hypoxia-inducible factor-1. Biochem. Biophys. Res. Commun. 333(3): 1026-
33.
1840. Hsu C, Boysen M, Gritton LD, Frosst PD, Nemerow GR, Von Seggern DJ. (2005)
In vitro dendritic cell infection by pseudotyped adenoviral vectors does not correlate with
their in vivo immunogenicity. Virology. 332(1): 1-7.
1841. Hu Y, Ma LF, Wu M, Wong MS, Li B, Corral S, Yu ZZ, Nomanbhoy T, Alemayehu
S, Fuller SR, Rosenblum JS, Rozenkrants N, Minimo LC, Ripka WC, Szardenings AK,
Kozarich JW, Shreder KR. (2005) Synthesis and structure-activity relationship of n-alkyl
gly-boro-pro inhibitors of dpp4, fap, and dpp7. Bioorg. Med. Chem. Lett. 15(19): 4239-
42.
1842. Huang HM, Gao YH. (2005) A method for generation of arbitrary peptide libraries
using genomic DNA. Mol. Biotechnol. 30(2): 135-42.
1843. Huang JK, Phillips GR, Roth AD, Pedraza L, Shan WS, Belkaid W, Mi S, Fex-
Svenningsen A, Florens L, Yates JR, Colman DR. (2005) Glial membranes at the node
of ranvier prevent neurite outgrowth. Science. 310(5755): 1813-7.
1844. Huh D, Gu W, Kamotani Y, Grotberg JB, Takayama S. (2005) Microfluidics for
flow cytometric analysis of cells and particles. Physiol. Meas. 26(3): R73-R98.
1845. Jessani N, Niessen S, Mueller BM, Cravatt BF. (2005) Breast cancer cell lines
grown in vivo - what goes in isn't always the same as what comes out. Cell Cycle. 4(2):
253-5.
1846. Jessani N, Niessen S, Wei BQQ, Nicolau M, Humphrey M, Ji YR, Han WS, Noh
DY, Yates JR, Jeffrey SS, Cravatt BF. (2005) A streamlined platform for high-content
functional proteomics of primary human specimens. Nat. Methods. 2(9): 691-7.
1847. Jessani N, Young JA, Diaz SL, Patricelli MP, Varki A, Cravatt BF. (2005) Class
assignment of sequence-unrelated members of enzyme superfamilies by activity-based
protein profiling. Angew. Chem.-Int. Edit. 44(16): 2400-3.
1848. Johnson SM, Petrassi HM, Palaninathan SK, Mohamedmohaideen NN, Purkey

HE, Nichols C, Chiang KP, Walkup T, Sacchettini JC, Sharpless KB, Kelly JW. (2005)
Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation. J. Med.
Chem. 48(5): 1576-87.
1849. Johnson SM, Wiseman RL, Sekijima Y, Green NS, Adamski-Werner SL, Kelly
JW. (2005) Native state kinetic stabilization as a strategy to ameliorate protein
misfolding diseases: A focus on the transthyretin amyloidoses. Accounts Chem. Res.
38(12): 911-21.
1850. Jun HW, Yuwono V, Paramonov SE, Hartgerink JD. (2005) Enzyme-mediated
degradation of peptide-amphiphile nanofiber networks. Adv. Mater. 17(21): 2612-+.
1851. Kang SA, Crane BR. (2005) Effects of interface mutations on association modes
and electron-transfer rates between proteins. Proc. Natl. Acad. Sci. U. S. A. 102(43):
15465-70.
1852. Kaufmann GF, Meijler MM, Sun CZ, Chen DW, Kujawa DP, Mee JM, Hoffman
TZ, Wirsching P, Lerner RA, Janda KD. (2005) Enzymatic incorporation of an antibodyactivated
blue fluorophore into DNA. Angew. Chem.-Int. Edit. 44(14): 2144-8.
1853. Kaufmann GF, Sartorio R, Lee SH, Rogers CJ, Meijler MM, Moss JA, Clapham B,
Brogan AP, Dickerson TJ, Janda KD. (2005) Revisiting quorum sensing: Discovery of
additional chemical and biological functions for 3-oxo-n-acylhomoserine lactones. Proc.
Natl. Acad. Sci. U. S. A. 102(2): 309-14.
1854. Kerns EH, Di L, Bourassa J, Gross J, Huang N, Liu HL, Kleintop T, Nogle L,
Mallis L, Petucci C, Petusky S, Tischler M, Sabus C, Sarkahian A, Young M, Zhang MY,
Huryn D, McConnell O, Carter G. (2005) Integrity profiling of high throughput screening
hits using lc-ms and related techniques. Comb. Chem. High Throughput Screen. 8(6):
459-66.
1855. Khachemoune A, Olbricht SM, Johnson DS. (2005) Microcystic adnexal
carcinoma: Report of four cases treated with mohs' micrographic surgical technique.
International Journal of Dermatology. 44(6): 507-12.
1856. Kim HS, Damo SM, Lee SY, Wemmer D, Klinman JP. (2005) Structure and
hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from
bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic
homologues. Biochemistry. 44(34): 11428-39.
1857. Kim Y, Lillo A, Moss JA, Janda KD. (2005) A contiguous stretch of methionine
residues mediates the energy-dependent internalization mechanism of a cellpenetrating
peptide. Mol. Pharm. 2(6): 528-35.
1858. Kinjo Y, Wu D, Kim GS, Xing GW, Poles MA, Ho DD, Tsuji M, Kawahara K,
Wong CH, Kronenberg M. (2005) Recognition of bacterial glycosphingolipids by natural
killer t cells. Nature. 434(7032): 520-5.
1859. Krasinski A, Radic Z, Manetsch R, Raushel J, Taylor P, Sharpless KB, Kolb HC.
(2005) In situ selection of lead compounds by click chemistry: Target-guided
optimization of acetylcholinesterase inhibitors. J. Am. Chem. Soc. 127(18): 6686-92.
1860. Leung D, Du W, Hardouin C, Cheng H, Hwang I, Cravatt BF, Boger DL. (2005)
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase
inhibitors enlistings enlisting proteome-wide selectivity screening: Concurrent
optimization of enzyme inhibitor potency and selectivity. Bioorg. Med. Chem. Lett. 15(5):

1423-8.
1861. Liang CH, Romero A, Rabuka D, Sgarbi PWM, Marby KA, Duffield J, Yao SL,
Cheng MLL, Ichikawa Y, Sears P, Hu CY, Hwang SB, Shue YK, Sucheck SJ. (2005)
Structure-activity relationships of bivalent aminoglycosides and evaluation of their
microbiological activities. Bioorg. Med. Chem. Lett. 15(8): 2123-8.
1862. Liang CH, Yao SL, Chiu YH, Leung PY, Robert N, Seddon J, Sears P, Hwang
CK, Ichikawa Y, Romero A. (2005) Synthesis and biological activity of new 5-o-sugar
modified ketolide and 2-fluoro-ketolide antibiotics. Bioorg. Med. Chem. Lett. 15(5): 1307-
10.
1863. Lichtman AH, Cravatt BF. (2005) Food for thought: Endocannabinoid modulation
of lipogenesis. J. Clin. Invest. 115(5): 1130-3.
1864. Lim MD, Capps KB, Karpishin TB, Ford PC. (2005) Further evidence supporting
an inner sphere mechanism in the no reduction of the copper(ii) complex cu(dmp)(2)(2+)
(dmp=2,9-dimethyl-1,10-phenanthroline). Nitric Oxide-Biol. Chem. 12(4): 244-51.
1865. Lindenbach BD, Evans MJ, Syder AJ, Wolk B, Tellinghuisen TL, Liu CC,
Maruyama T, Hynes RO, Burton DR, McKeating JA, Rice CM. (2005) Complete
replication of hepatitis c virus in cell culture. Science. 309(5734): 623-6.
1866. Liu F, Whitton JL. (2005) Cutting edge: Re-evaluating the in vivo cytokine
responses of cd8(+) t cells during primary and secondary viral infections. J. Immunol.
174(10): 5936-40.
1867. Liu H, Tully DC, Epple R, Bursulaya B, Li J, Harris JL, Williams JA, Russo R,
Tumanut C, Roberts MJ, Alper PB, He Y, Karanewsky DS. (2005) Design and synthesis
of arylaminoethyl amides as noncovalent inhibitors of cathepsin s. Part i. Bioorg. Med.
Chem. Lett. 15(22): 4979-84.
1868. Liu HQ, Du X, Wang M, Huang QL, Ding LL, McDonald HW, Yates JR, Beutler B,
Horwitz J, Gong XH. (2005) Crystallin gamma b-i4f mutant protein binds to alphacrystallin
and affects lens transparency. J. Biol. Chem. 280(26): 25071-8.
1869. Liu J, Bang AG, Kintner C, Orth AP, Chanda SK, Ding S, Schultz PG. (2005)
Identification of the wnt signaling activator leucine-rich repeat in flightless interaction
protein 2 by a genome-wide functional analysis. Proc. Natl. Acad. Sci. U. S. A. 102(6):
1927-32.
1870. Liu J, Wu X, Mitchell B, Kintner C, Ding S, Schultz PG. (2005) A small-molecule
agonist of the wnt signaling pathway. Angew. Chem.-Int. Edit. 44(13): 1987-90.
1871. Liu YS, Shreder KR, Gai WZ, Corral S, Ferris DK, Rosenblum JS. (2005)
Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits
mammalian polo-like kinase. Chem. Biol. 12(1): 99-107.
1872. Luesch H, Wu TYH, Ren PD, Gray NS, Schultz PG, Supek F. (2005) A genomewide
overexpression screen in yeast for small-molecule target identification. Chem. Biol.
12(1): 55-63.
1873. Lund CV, Popkov M, Magnenat L, Barbas CF. (2005) Zinc finger transcription
factors designed for bispecific coregulation of erbb2 and erbb3 receptors: Insights into
erbb receptor biology. Mol. Cell. Biol. 25(20): 9082-91.
1874. Macpherson LJ, Geierstanger BH, Viswanath V, Bandell M, Eid SR, Hwang S,
Patapoutian A. (2005) The pungency of garlic: Activation of trpa1 and trpv1 in response

to allicin. Curr. Biol. 15(10): 929-34.
1875. Malkoch M, Schleicher K, Drockenmuller E, Hawker CJ, Russell TP, Wu P, Fokin
VV. (2005) Structurally diverse dendritic libraries: A highly efficient functionalization
approach using click chemistry. Macromolecules. 38(9): 3663-78.
1876. Manuell AL, Yamaguchi K, Haynes PA, Milligan RA, Mayfield SP. (2005)
Composition and structure of the 80 s ribosome from the green alga chlamydomonas
reinhardtii: 80 s ribosomes are conserved in plants and animals. J. Mol. Biol. 351(2):
266-79.
1877. Martinez X, Kreuwel HTC, Redmond WL, Trenney R, Hunter K, Rosen H,
Sarvetnick N, Wicker LS, Sherman LA. (2005) Cd8(+) t cell tolerance in nonobese
diabetic mice is restored by insulin-dependent diabetes resistance alleles. J. Immunol.
175(3): 1677-85.
1878. McElheny D, Schnell JR, Lansing JC, Dyson HJ, Wright PE. (2005) Defining the
role of active-site loop fluctuations in dihydrofolate reductase catalysis. Proc. Natl. Acad.
Sci. U. S. A. 102(14): 5032-7.
1879. McKenzie KM, Meijler MM, Lowery CA, Boldt GE, Janda KD. (2005) A furanosylcarbonate
autoinducer in cell-to-cell communication of v-harveyi. Chem. Commun. (38):
4863-5.
1880. McKinney MK, Cravatt BF. (2005) Structure and function of fatty acid amide
hydrolase. Annu. Rev. Biochem. 74: 411-32.
1881. McNulty JC, Jackson PJ, Thompson DA, Chai BX, Gantz I, Barsh GS, Dawson
PE, Millhauser GL. (2005) Structures of the agouti signaling protein. J. Mol. Biol. 346(4):
1059-70.
1882. Meijler MM, Kaufmann GF, Qi LW, Mee JM, Coyle AR, Moss JA, Wirsching P,
Matsushita M, Janda KD. (2005) Fluorescent cocaine probes: A tool for the selection
and engineering of therapeutic antibodies. J. Am. Chem. Soc. 127(8): 2477-84.
1883. Mercer AC, Burkart MD. (2005) Enzyme-assisted antibiotic engineering - the
wright way. Chem. Biol. 12(2): 147-8.
1884. Mercer AC, La Clair JJ, Burkart MD. (2005) Fluorescent multiplex analysis of
carrier protein post-translational modification. Chembiochem. 6(8): 1335-7.
1885. Metanis N, Keinan E, Dawson PE. (2005) A designed synthetic analogue of 4-ot
is specific for a non-natural substrate. J. Am. Chem. Soc. 127(16): 5862-8.
1886. Moss JA, Lillo A, Kim YS, Gao CS, Ditzel H, Janda KD. (2005) A dimerization
"Switch" In the internalization mechanism of a cell-penetrating peptide. J. Am. Chem.
Soc. 127(2): 538-9.
1887. Moulin E, Barluenga S, Winssinger N. (2005) Concise synthesis of pochonin a,
an hsp90 inhibitor. Org. Lett. 7(25): 5637-9.
1888. Moulin E, Zoete V, Barluenga S, Karplus M, Winssinger N. (2005) Design,
synthesis, and biological evaluation of hsp90 inhibitors based on conformational
analysis of radicicol and its analogues. J. Am. Chem. Soc. 127(19): 6999-7004.
1889. Neuman BW, Stein DA, Kroeker AD, Churchill MJ, Kim AM, Kuhn P, Dawson P,
Moulton HM, Bestwick RK, Iversen PL, Buchmeier MJ. (2005) Inhibition, escape, and
attenuated growth of severe acute respiratory syndrome coronavirus treated with
antisense morpholino oligomers. J. Virol. 79(15): 9665-76.

1890. Nicklin SA, Wu E, Nemerow GR, Baker AH. (2005) The influence of adenovirus
fiber structure and function on vector development for gene therapy. Mol. Ther. 12(3):
384-93.
1891. Nicolaou KC, Estrada AA, Zak M, Lee SH, Safina BS. (2005) A mild and selective
method for the hydrolysis of esters with trimethyltin hydroxide. Angew. Chem.-Int. Edit.
44(9): 1378-82.
1892. Nicolaou KC, Lee SH, Estrada AA, Zak M. (2005) Construction of substituted nhydroxyindoles:
Synthesis of a nocathiacin i model system. Angew. Chem.-Int. Edit.
44(24): 3736-40.
1893. Nicolaou KC, Mathison CJN. (2005) Synthesis of imides, n-acyl vinylogous
carbamates and ureas, and nitriles by oxidation of amides and amines with dess-martin
periodinane. Angew. Chem.-Int. Edit. 44(37): 5992-7.
1894. Nicolaou KC, Montagnon T, Vassilikogiannakis G, Mathison CJN. (2005) The
total synthesis of coleophomones b, c, and d. J. Am. Chem. Soc. 127(24): 8872-88.
1895. Nicolaou KC, Safina BS, Zak M, Lee SH, Nevalainen M, Bella M, Estrada AA,
Funke C, Zecri FJ, Bulat S. (2005) Total synthesis of thiostrepton. Retrosynthetic
analysis and construction of key building blocks. J. Am. Chem. Soc. 127(31): 11159-75.
1896. Nicolaou KC, Sasmal PK, Koftis TV, Converso A, Loizidou E, Kaiser F, Roecker
AJ, Dellios CC, Sun XW, Petrovic G. (2005) Studies toward the synthesis of
azadirachtin, part 2: Construction of fully functionalized abcd ring frameworks and
unusual intramolecular reactions induced by close-proximity effects. Angew. Chem.-Int.
Edit. 44(22): 3447-52.
1897. Nicolaou KC, Sasmal PK, Roecker AJ, Sun XW, Mandal S, Converso A. (2005)
Studies toward the synthesis of azadirachtin, part 1: Total synthesis of a fully
functionalized abc ring framework and coupling with a norbornene domain. Angew.
Chem.-Int. Edit. 44(22): 3443-7.
1898. Nicolaou KC, Snyder SA. (2005) Chasing molecules that were never there:
Misassigned natural products and the role of chemical synthesis in modern structure
elucidation. Angew. Chem.-Int. Edit. 44(7): 1012-44.
1899. Nicolaou KC, Tang WJ, Dagneau P, Faraoni R. (2005) A catalytic asymmetric
three-component 1,4-addition/aldol reaction: Enantioselective synthesis of the
spirocyclic system of vannusal a. Angew. Chem.-Int. Edit. 44(25): 3874-9.
1900. Nicolaou KC, Xu H, Wartmann M. (2005) Biomimetic total synthesis of gambogin
and rate acceleration of pericyclic reactions in aqueous media. Angew. Chem.-Int. Edit.
44(5): 756-61.
1901. Nicolaou KC, Zak M, Rahimipour S, Estrada AA, Lee SH, O'Brate A,
Giannakakou P, Ghadiri MR. (2005) Discovery of a biologically active thiostrepton
fragment. J. Am. Chem. Soc. 127(43): 15042-4.
1902. Nicolaou KC, Zak M, Safina BS, Estrada AA, Lee SH, Nevalainen M. (2005) Total
synthesis of thiostrepton. Assembly of key building blocks and completion of the
synthesis. J. Am. Chem. Soc. 127(31): 11176-83.
1903. Niculescu AB. (2005) Genomic studies of mood disorders - the brain as a
muscle? Genome Biol. 6(4): 4.
1904. Nomura DK, Leungt D, Chiang KP, Quistad GB, Cravatt BF, Casida JE. (2005) A

ain detoxifying enzyme for organophosphorus nerve poisons. Proc. Natl. Acad. Sci. U.
S. A. 102(17): 6195-200.
1905. Nyffeler PT, Duron SG, Burkart MD, Vincent SP, Wong CH. (2005) Selectfluor:
Mechanistic insight and applications. Angew. Chem.-Int. Edit. 44(2): 192-212.
1906. O'Shea PD, Chen CY, Chen WR, Dagneau P, Frey LF, Grabowski EJJ,
Marcantonio KM, Reamer RA, Tan LS, Tillyer RD, Roy A, Wang X, Zhao DL. (2005)
Practical asymmetric synthesis of a potent pde4 inhibitor via stereoselective enolate
alkylation of a chiral aryl-heteroaryl secondary tosylate. J. Org. Chem. 70(8): 3021-30.
1907. Okerberg ES, Wu JY, Zhang BH, Samii B, Blackford K, Winn DT, Shreder KR,
Burbaum JJ, Patricelli MP. (2005) High-resolution functional proteomics by active-site
peptide profiling. Proc. Natl. Acad. Sci. U. S. A. 102(14): 4996-5001.
1908. Osei-Hyiaman D, Depetrillo M, Harvey-White J, Bannon AW, Cravatt BF, Kuhar
MJ, Mackie K, Palkovits M, Kunos G. (2005) Cocaine- and amphetamine-related
transcript is involved in the orexigenic effect of endogenous anandamide.
Neuroendocrinology. 81(4): 273-82.
1909. Ozer A, Bruick RK. (2005) Regulation of hif by prolyl hydroxylases - recruitment
of the candidate tumor suppressor protein ing4. Cell Cycle. 4(9): 1153-6.
1910. Ozer A, Wu LC, Bruick RK. (2005) The candidate tumor suppressor ing4
represses activation of the hypoxia inducible factor (hif). Proc. Natl. Acad. Sci. U. S. A.
102(21): 7481-6.
1911. Pacher P, Batkai S, Osei-Hyiaman D, Offertaler L, Liu J, Harvey-White J, Brassai
A, Jarai Z, Cravatt BF, Kunos G. (2005) Hemodynamic profile, responsiveness to
anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. Am.
J. Physiol.-Heart Circul. Physiol. 289(2): H533-H41.
1912. Page LJ, Suk JY, Huff ME, Lim HJ, Venable J, Yates J, Kelly JW, Balch WE.
(2005) Metalloendoprotease cleavage triggers gelsolin amyloidogenesis. Embo J.
24(23): 4124-32.
1913. Palmer LC, Rebek J. (2005) Hydrocarbon binding inside a hexameric
pyrogallol[4]arene capsule. Org. Lett. 7(5): 787-9.
1914. Palmer LC, Shivanyuk A, Yamanaka M, Rebek J. (2005) Resorcinarene
assemblies as synthetic receptors. Chem. Commun. (7): 857-8.
1915. Palmer LC, Zhao YL, Houk KN, Rebek J. (2005) Diastereoselection of chiral
acids in a cylindrical capsule. Chem. Commun. (29): 3667-9.
1916. Panda S, Nayak SK, Campo B, Walker JR, Hogenesch JB, Jegla T. (2005)
Illumination of the melanopsin signaling pathway. Science. 307(5709): 600-4.
1917. Pant K, Crane BR. (2005) Structure of a loose dimer: An intermediate in nitric
oxide synthase assembly. J. Mol. Biol. 352(4): 932-40.
1918. Paramonov SE, Gauba V, Hartgerink JD. (2005) Synthesis of collagen-like
peptide polymers by native chemical ligation. Macromolecules. 38(18): 7555-61.
1919. Patel S, Carrier EJ, Ho WSV, Rademacher DJ, Cunningham S, Reddy DS, Falck
JR, Cravatt BF, Hillard CJ. (2005) The postmortal accumulation of brain narachidonylethanolamine
(anandamide) is dependent upon fatty acid amide hydrolase
activity. J. Lipid Res. 46(2): 342-9.
1920. Patel S, Cravatt BF, Hillard CJ. (2005) Synergistic interactions between

cannabinoids and environmental stress in the activation of the central amygdala.
Neuropsychopharmacology. 30(3): 497-507.
1921. Petrassi HM, Johnson SM, Purkey HE, Chiang KP, Walkup T, Jiang X, Powers
ET, Kelly JW. (2005) Potent and selective structure-based dibenzofuran inhibitors of
transthyretin amyloidogenesis: Kinetic stabilization of the native state. J. Am. Chem.
Soc. 127(18): 6662-71.
1922. Petrassi HM, Williams JA, Li J, Tumanut C, Ek J, Nakai T, Masick B, Backes BJ,
Harris JL. (2005) A strategy to profile prime and non-prime proteolytic substrate
specificity. Bioorg. Med. Chem. Lett. 15(12): 3162-6.
1923. Pfefferkorn JA, Greene ML, Nugent RA, Gross RJ, Mitchell MA, Finzel BC, Harris
MS, Wells PA, Shelly JA, Anstadt RA, Kilkuskie RE, Kopta LA, Schwende FJ. (2005)
Inhibitors of hcvns5b polymerase. Part 1: Evaluation of the southern region of (2z)-2-
(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid. Bioorg. Med. Chem. Lett. 15(10): 2481-
6.
1924. Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk
LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE,
Kopta LA, Schwende FJ. (2005) Inhibitors of hcvns5b polymerase. Part 2: Evaluation of
the northern region of (2z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid. Bioorg.
Med. Chem. Lett. 15(11): 2812-8.
1925. Phillips GR, Florens L, Tanaka H, Khaing ZZ, Fidler L, Yates JR, Colman DR.
(2005) Proteomic comparison of two fractions derived from the transsynaptic scaffold. J.
Neurosci. Res. 81(6): 762-75.
1926. Ponti A, Matov A, Adams M, Gupton S, Waterman-Storer CM, Danuser G. (2005)
Periodic patterns of actin turnover in lamellipodia and lamellae of migrating epithelial
cells analyzed by quantitative fluorescent speckle microscopy. Biophys. J. 89(5): 3456-
69.
1927. Premkumar L, Sawkar AR, Boldin-Adamsky S, Toker L, Silman I, Kelly JW,
Futerman AH, Sussman JL. (2005) X-ray structure of human acid-beta-glucosidase
covalently bound to conduritol-b-epoxide - implications for gaucher disease. J. Biol.
Chem. 280(25): 23815-9.
1928. Punna S, Kaltgrad E, Finn MG. (2005) "Clickable" Agarose for affinity
chromatography. Bioconjugate Chem. 16(6): 1536-41.
1929. Purse BW, Gissot A, Rebek J. (2005) A deep cavitand provides a structured
environment for the menschutkin reaction. J. Am. Chem. Soc. 127(32): 11222-3.
1930. Purse BW, Rebek J. (2005) Encapsulation of oligoethylene glycols and perfluoron-alkanes
in a cylindrical host molecule. Chem. Commun. (6): 722-4.
1931. Purse BW, Rebek J. (2005) Functional cavitands: Chemical reactivity in
structured environments. Proc. Natl. Acad. Sci. U. S. A. 102(31): 10777-82.
1932. Putnam CD, Pennaneach V, Kolodner RD. (2005) Saccharomyces cerevisiae as
a model system to define the chromosomal instability phenotype. Mol. Cell. Biol. 25(16):
7226-38.
1933. Quezada CM, Hamel DJ, Gradinaru C, Bilwes AM, Dahlquist FW, Crane BR,
Simon MI. (2005) Structural and chemical requirements for histidine phosphorylation by
the chemotaxis kinase chea. J. Biol. Chem. 280(34): 30581-5.

1934. Rae CS, Khor IW, Wang Q, Destito G, Gonzalez MJ, Singh P, Thomas DM,
Estrada MN, Powell E, Finn MG, Manchester M. (2005) Systemic trafficking of plant
virus nanoparticles in mice via the oral route. Virology. 343(2): 224-35.
1935. Razavi H, Powers ET, Purkey HE, Adamski-Werner SL, Chiang KP, Dendle MTA,
Kelly JW. (2005) Design, synthesis, and evaluation of oxazole transthyretin
amyloidogenesis inhibitors. Bioorg. Med. Chem. Lett. 15(4): 1075-8.
1936. Redmond WL, Marincek BC, Sherman LA. (2005) Distinct requirements for
deletion versus anergy during cd8 t cell peripheral tolerance in vivo. J. Immunol. 174(4):
2046-53.
1937. Redmond WL, Sherman LA. (2005) Peripheral tolerance of cd8 t lymphocytes.
Immunity. 22(3): 275-84.
1938. Reed NN, Dickerson TJ, Boldt GE, Janda KD. (2005) Enantioreversal in the
sharpless asymmetric epoxidation reaction controlled by the molecular weight of a
covalently appended achiral polymer. J. Org. Chem. 70(5): 1728-31.
1939. Reeder MD, Srikanth GSC, Jones SB, Castle SL. (2005) Synthesis of the core
structure of acutumine. Org. Lett. 7(6): 1089-92.
1940. Rodionov VO, Fokin VV, Finn MG. (2005) Mechanism of the ligand-free cu-icatalyzed
azide-alkyne cycloaddition reaction. Angew. Chem.-Int. Edit. 44(15): 2210-5.
1941. Rogers CJ, Dickerson TJ, Brogan AP, Janda KD. (2005) Hammett correlation of
nornicotine analogues in the aqueous aldol reaction: Implications for green
organocatalysis. J. Org. Chem. 70(9): 3705-8.
1942. Rogers CJ, Dickerson TJ, Wentworth P, Janda KD. (2005) A high-swelling
reagent scaffold suitable for use in aqueous and organic solvents. Tetrahedron. 61(51):
12140-4.
1943. Rogers CJ, Mee JM, Kaufmann GF, Dickerson TJ, Janda KD. (2005) Toward
cocaine esterase therapeutics. J. Am. Chem. Soc. 127(28): 10016-7.
1944. Rowbottom MW, Vickers TD, Dyck B, Tamiya J, Zhang MZ, Zhao LR, Grey J,
Provencal D, Schwarz D, Heise CE, Mistry M, Fisher A, Dong T, Hu T, Saunders J,
Goodfellow VS. (2005) Synthesis and structure-activity relationships of
biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the
melanin-concentrating hormone receptor-1 (mch-r1). Bioorg. Med. Chem. Lett. 15(14):
3439-45.
1945. Rudic RD, McNamara P, Reilly D, Grosser T, Curtis AM, Price TS, Panda S,
Hogenesch JB, FitzGerald GA. (2005) Bioinformatic analysis of circadian gene
oscillation in mouse aorta. Circulation. 112(17): 2716-24.
1946. Saghatelian A, Cravatt BF. (2005) Global strategies to integrate the proteome
and metabolome. Curr. Opin. Chem. Biol. 9(1): 62-8.
1947. Saghatelian A, Cravatt BF. (2005) Assignment of protein function in the
postgenomic era. Nat. Chem. Biol. 1(3): 130-42.
1948. Sawkar AR, Adamski-Werner SL, Cheng WC, Wong CH, Beutler E, Zimmer KP,
Kelly JW. (2005) Gaucher disease-associated glucocerebrosidases show mutationdependent
chemical chaperoning profiles. Chem. Biol. 12(11): 1235-44.
1949. Schnell JR, Zhou GP, Zweckstetter M, Rigby AC, Chou JJ. (2005) Rapid and
accurate structure determination of coiled-coil domains using nmr dipolar couplings:

Application to cgmp-dependent protein kinase i alpha. Protein Sci. 14(9): 2421-8.
1950. Schnermann MJ, Boger DL. (2005) Total synthesis of piericidin a1 and b1. J. Am.
Chem. Soc. 127(45): 15704-5.
1951. Schrofelbauer B, Yu Q, Zeitlin SG, Landau NR. (2005) Human immunodeficiency
virus type 1 vpr induces the degradation of the ung and smug uracil-DNA glycosylases.
J. Virol. 79(17): 10978-87.
1952. Schuerch DW, Wilson-Kubalek EM, Tweten RK. (2005) Molecular basis of
listeriolysin o ph dependence. Proc. Natl. Acad. Sci. U. S. A. 102(35): 12537-42.
1953. Sekijima Y, Wiseman RL, Matteson J, Hammarstrom P, Miller SR, Sawkar AR,
Balch WE, Kelly JW. (2005) The biological and chemical basis for tissue-selective
amyloid disease. Cell. 121(1): 73-85.
1954. Sen Gupta S, Kuzelka J, Singh P, Lewis WG, Manchester M, Finn MG. (2005)
Accelerated bioorthogonal conjugation: A practical method for the ligation of diverse
functional molecules to a polyvalent virus scaffold. Bioconjugate Chem. 16(6): 1572-9.
1955. Sen Gupta S, Raja KS, Kaltgrad E, Strable E, Finn MG. (2005) Virusglycopolymer
conjugates by copper(i) catalysis of atom transfer radical polymerization
and azide-alkyne cycloaddition. Chem. Commun. (34): 4315-7.
1956. Sharp LL, Jameson JM, Witherden DA, Komori HK, Havran WL. (2005) Dendritic
epidermal t-cell activation. Crit. Rev. Immunol. 25(1): 1-17.
1957. Sharpless WD, Wu P, Hansen TV, Lindberg JG. (2005) Just click it:
Undergraduate procedures for the copper(i)-catalyzed formation of 1,2,3-triazoles from
azides and terminal acetylenes. J. Chem. Educ. 82(12): 1833-6.
1958. Sheinerman FB, Giraud E, Laoui A. (2005) High affinity targets of protein kinase
inhibitors have similar residues at the positions energetically important for binding. J.
Mol. Biol. 352(5): 1134-56.
1959. Shie JJ, Fang JM, Kuo CJ, Kuo TH, Liang PH, Huang HJ, Yang WB, Lin CH,
Chen JL, Wu YT, Wong CH. (2005) Discovery of potent anilide inhibitors against the
severe acute respiratory syndrome 3cl protease. J. Med. Chem. 48(13): 4469-73.
1960. Shipe WD, Wolkenberg SE, Williams DL, Lindsley CW. (2005) Recent advances
in positive allosteric modulators of metabotropic glutamate receptors. Curr. Opin. Drug
Discov. Dev. 8(4): 449-57.
1961. Shreder KR, Wong MS, Corral S, Yu ZZ, Winn DT, Wu M, Hu Y, Nomanbhoy T,
Alemayehu S, Fuller SR, Rosenblum JS, Kozarich JW. (2005) Boro-norleucine as a p1
residue for the design of selective and potent dpp7 inhibitors. Bioorg. Med. Chem. Lett.
15(19): 4256-60.
1962. Shute TS, Matsushita M, Dickerson TJ, La Clair JJ, Janda KD, Burkart MD.
(2005) A site-specific bifunctional protein labeling system for affinity and fluorescent
analysis. Bioconjugate Chem. 16(6): 1352-5.
1963. Somanchi A, Barnes D, Mayfield SP. (2005) A nuclear gene of chlamydomonas
reinhardtii, tba1, encodes a putative oxidoreductase required for translation of the
chloroplast psba mrna. Plant J. 42(3): 341-52.
1964. Song JW, Gu W, Futai N, Warner KA, Nor JE, Takayama S. (2005) Computercontrolled
microcirculatory support system for endothelial cell culture and shearing.
Anal. Chem. 77(13): 3993-9.

1965. Speers AE, Cravatt BF. (2005) A tandem orthogonal proteolysis strategy for highcontent
chemical proteomics. J. Am. Chem. Soc. 127(28): 10018-9.
1966. Srikanth GSC, Castle SL. (2005) Advances in radical conjugate additions.
Tetrahedron. 61(44): 10377-441.
1967. Stray SJ, Bourne CR, Punna S, Lewis WG, Finn MG, Zlotnick A. (2005) A
heteroaryldihydropyrimidine activates and can misdirect hepatitis b virus capsid
assembly. Proc. Natl. Acad. Sci. U. S. A. 102(23): 8138-43.
1968. Suh R, Takayama S, Smith GD. (2005) Microfluidic applications for andrology. J.
Androl. 26(6): 664-70.
1969. Takagi Y, Masuda CA, Chang WH, Komori H, Wang D, Hunter T, Joazeiro CAP,
Kornberg RD. (2005) Ubiquitin ligase activity of tfiih and the transcriptional response to
DNA damage. Mol. Cell. 18(2): 237-43.
1970. Talkington MWT, Siuzdak G, Williamson JR. (2005) An assembly landscape for
the 30s ribosomal subunit. Nature. 438(7068): 628-32.
1971. Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang ZB, Zhang
HC, Teng Q, Nicholson AC, Giannakakou P, Zhou W, Olson JJ, Pereira MM, Nicolaou
KN, Van Meir EG. (2005) Identification of a novel small-molecule inhibitor of the
hypoxia-inducible factor 1 pathway. Cancer Res. 65(2): 605-12.
1972. Tang YT, Hu TH, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD. (2005)
Paqr proteins: A novel membrane receptor family defined by an ancient 7transmembrane
pass motif. J. Mol. Evol. 61(3): 372-80.
1973. Tang YT, Hu TH, Arterburn M, Boyle B, Bright JM, Palencia S, Emtage PC, Funk
WD. (2005) The complete complement of c1q-domain-containing proteins in homo
sapiens. Genomics. 86(1): 100-11.
1974. Thayer DA, Yu HN, Galan MC, Wong CH. (2005) A general strategy toward slinked
glycopeptides. Angew. Chem.-Int. Edit. 44(29): 4596-9.
1975. Thorpe IF, Brooks CL. (2005) Conformational substates modulate hydride
transfer in dihydrofolate reductase. J. Am. Chem. Soc. 127(37): 12997-3006.
1976. Toker JD, Tremblay MR, Yli-Kauhaluoma J, Wentworth AD, Zhou B, Wentworth
P, Janda KD. (2005) Exploring the scope of the 29g12 antibody catalyzed 1,3-dipolar
cycloaddition reaction. J. Org. Chem. 70(20): 7810-5.
1977. Tubbs JL, Tainer JA, Getzoff ED. (2005) Crystallographic structures of
discosoma red fluorescent protein with immature and mature chromophores: Linking
peptide bond trans-cis isomerization and acylimine formation in chromophore
maturation. Biochemistry. 44(29): 9833-40.
1978. Turnbull IR, McDunn JE, Takai T, Townsend RR, Cobb JP, Colonna M. (2005)
Dap12 (karap) amplifies inflammation and increases mortality from endotoxemia and
septic peritonitis. J. Exp. Med. 202(3): 363-9.
1979. Turner JM, Graziano J, Spraggon G, Schultz PG. (2005) Structural
characterization of a p-acetylphenylalanyl aminoacyl-trna synthetase. J. Am. Chem.
Soc. 127(43): 14976-7.
1980. Vaillancourt FH, Yeh E, Vosburg DA, O'Connor SE, Walsh CT. (2005) Cryptic
chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.
Nature. 436(7054): 1191-4.

1981. van Maarseveen JH, Horne WS, Ghadiri MR. (2005) Efficient route to c-2
symmetric heterocyclic backbone modified cyclic peptides. Org. Lett. 7(20): 4503-6.
1982. Venable JD, Cai H, Chai WY, Dvorak CA, Grice CA, Jablonowski JA, Shah CR,
Kwok AK, Ly KS, Pio B, Wei JM, Desai PJ, Jiang W, Nguyen S, Ling P, Wilson SJ,
Dunford PJ, Thurmond RL, Lovenberg TW, Karlsson L, Carruthers NI, Edwards JP.
(2005) Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole
piperazine carboxamides: Potent human histamine h-4 antagonists. J. Med. Chem.
48(26): 8289-98.
1983. Wang YX, Putnam CD, Kane MF, Zhang WJ, Edelmann L, Russell R, Carrion
DV, Chin L, Kucherlapati R, Kolodner RD, Edelmann W. (2005) Mutation in rpa1 results
in defective DNA double-strand break repair, chromosomal instability and cancer in
mice. Nature Genet. 37(7): 750-5.
1984. Want EJ, Cravatt BF, Siuzdak G. (2005) The expanding role of mass
spectrometry in metabolite profiling and characterization. Chembiochem. 6(11): 1941-
51.
1985. Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo EJ, Wong CH, Parker I,
Cahalan MD. (2005) Sphingosine 1-phosphate type 1 receptor agonism inhibits
transendothelial migration of medullary t cells to lymphatic sinuses. Nat. Immunol. 6(12):
1228-35.
1986. Weinstein DS, Liu W, Gu ZX, Langevine C, Ngu K, Fadnis L, Combs DW, Sitkoff
D, Ahmad S, Zhuang SB, Chen X, Wang FL, Loughney DA, Atwal KS, Zahler R, Macor
JE, Madsen CS, Murugesan N. (2005) Tryptamine and homotryptamine-based
sulfonamides as potent and selective inhibitors of 15-lipoxygenase. Bioorg. Med. Chem.
Lett. 15(5): 1435-40.
1987. Wilkens SJ, Janes J, Su AI. (2005) Hiers: Hierarchical scaffold clustering using
topological chemical graphs. J. Med. Chem. 48(9): 3182-93.
1988. Winssinger N, Harris JL. (2005) Microarray-based functional protein profiling
using peptide nucleic acid-encoded libraries. Expert Rev. Proteomics. 2(6): 937-47.
1989. Wiseman RL, Balch WE. (2005) A new pharmacology - drugging stressed folding
pathways. Trends Mol. Med. 11(8): 347-50.
1990. Wiseman RL, Green NS, Kelly JW. (2005) Kinetic stabilization of an oligomeric
protein under physiological conditions demonstrated by a lack of subunit exchange:
Implications for transthyretin amyloidosis. Biochemistry. 44(25): 9265-74.
1991. Wiseman RL, Johnson SM, Kelker MS, Foss T, Wilson IA, Kelly JW. (2005)
Kinetic stabilization of an oligomeric protein by a single ligand binding event. J. Am.
Chem. Soc. 127(15): 5540-51.
1992. Wiseman RL, Powers ET, Kelly JW. (2005) Partitioning conformational
intermediates between competing refolding and aggregation pathways: Insights into
transthyretin amyloid disease. Biochemistry. 44(50): 16612-23.
1993. Wolkenberg SE, Shipe WD, Lindsley CW, Guare JP, Pawluczyk JM. (2005)
Applications of microwave-assisted organic synthesis on the multigram scale. Curr.
Opin. Drug Discov. Dev. 8(6): 701-8.
1994. Wu CY, Brik A, Wang SK, Chen YH, Wong CH. (2005) Tetrabutylammonium
fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of

enzyme inhibitors in situ. Chembiochem. 6(12): 2176-80.
1995. Wu D, Xing GW, Poles MA, Horowitz A, Kinjo Y, Sullivan B, Bodmer-Narkevitch
V, Plettenburg O, Kronenberg M, Tsuji M, Ho DD, Wong CH. (2005) Bacterial glycolipids
and analogs as antigens for cd1d-restricted nkt cells. Proc. Natl. Acad. Sci. U. S. A.
102(5): 1351-6.
1996. Wu P, Malkoch M, Hunt JN, Vestberg R, Kaltgrad E, Finn MG, Fokin VV,
Sharpless KB, Hawker CJ. (2005) Multivalent, bifunctional dendrimers prepared by click
chemistry. Chem. Commun. (46): 5775-7.
1997. Wunder F, Tersteegen A, Rebmann A, Erb C, Fahrig T, Hendrix M. (2005)
Characterization of the first potent and selective pde9 inhibitor using a cgmp reporter
cell line. Mol. Pharmacol. 68(6): 1775-81.
1998. Xie JM, Schultz PG. (2005) Adding amino acids to the genetic repertoire. Curr.
Opin. Chem. Biol. 9(6): 548-54.
1999. Xie JM, Schultz PG. (2005) An expanding genetic code. Methods. 36(3): 227-38.
2000. Xing GW, Wu D, Poles MA, Horowitz A, Tsuji M, Ho DD, Wong CH. (2005)
Synthesis and human nkt cell stimulating properties of 3-o-sulfo-alpha/betagalactosylceramides.
Bioorg. Med. Chem. 13(8): 2907-16.
2001. Xu Y, Yamamoto N, Ruiz DI, Kubitz DS, Janda KD. (2005) Squaric monoamide
monoester as a new class of reactive immunization hapten for catalytic antibodies.
Bioorg. Med. Chem. Lett. 15(19): 4304-7.
2002. Yachi PP, Ampudia J, Gascoigne NRJ, Zal T. (2005) Nonstimulatory peptides
contribute to antigen-induced cd8-t cell receptor interaction at the immunological
synapse. Nat. Immunol. 6(8): 785-92.
2003. Yadav MK, Gerdts CJ, Sanishvili R, Smith WW, Roach LS, Ismagilov RF, Kuhn
P, Stevens RC. (2005) In situ data collection and structure refinement from
microcapillary protein crystallization. J. Appl. Crystallogr. 38: 900-5.
2004. Yadav MK, Redman JE, Leman LJ, Alvarez-Gutierrez JM, Zhang YM, Stout CD,
Ghadiri MR. (2005) Structure-based engineering of internal cavities in coiled-coil
peptides. Biochemistry. 44(28): 9723-32.
2005. Yang J, Su AI, Li WH. (2005) Gene expression evolves faster in narrowly than in
broadly expressed mammalian genes. Mol. Biol. Evol. 22(10): 2113-8.
2006. Yang JS, Zhang L, Erbel PJA, Gardner KH, Ding K, Garcia JA, Bruick RK. (2005)
Functions of the per/arnt/sim domains of the hypoxia-inducible factor. J. Biol. Chem.
280(43): 36047-54.
2007. Yin YH, Vafeados D, Tao Y, Yoshida S, Asami T, Chory J. (2005) A new class of
transcription factors mediates brassinosteroid-regulated gene expression in arabidopsis.
Cell. 120(2): 249-59.
2008. Young JA, Fivelman QL, Blair PL, de la Vega P, Le Roch KG, Zhou YY, Carucci
DJ, Baker DA, Winzeler EA. (2005) The plasmodium falciparum sexual development
transcriptome: A microarray analysis using ontology-based pattern identification. Mol.
Biochem. Parasitol. 143(1): 67-79.
2009. Young JA, Winzeler EA. (2005) Using expression information to discover new
drug and vaccine targets in the malaria parasite plasmodium falciparum.
Pharmacogenomics. 6(1): 17-26.

2010. Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA.
(2005) Structural basis for cd1d presentation of a sulfatide derived from myelin and its
implications for autoimmunity. J. Exp. Med. 202(11): 1517-26.
2011. Zeitlin SG, Patel S, Kavli B, Slupphaug G. (2005) Xenopus cenp - a assembly
into chromatin requires base excision repair proteins. DNA Repair. 4(7): 760-72.
2012. Zhang Y, Wang L, Schultz PG, Wilson IA. (2005) Crystal structures of apo wildtype
m-jannaschii tyrosyl-trna synthetase (tyrrs) and an engineered tyrrs specific for omethyl-l-tyrosine.
Protein Sci. 14(5): 1340-9.
2013. Zhao YX, Clark J, Ding S. (2005) Genomic studies in stem cell systems. Curr.
Opin. Mol. Ther. 7(6): 543-50.
2014. Zhong JF, Zhao Y, Sutton S, Su A, Zhan YX, Zhu LJ, Yan CL, Gallaher T,
Johnston PB, Anderson WF, Cooke MP. (2005) Gene expression profile of murine longterm
reconstituting vs. Short-term reconstituting hematopoietic stem cells. Proc. Natl.
Acad. Sci. U. S. A. 102(7): 2448-53.
2015. Zhou YY, Young JA, Santrosyan A, Chen KS, Yan SF, Winzeler EA. (2005) In
silico gene function prediction using ontology-based pattern identification.
Bioinformatics. 21(7): 1237-45.
2016. Zhu XY, Mills KL, Peters PR, Bahng JH, Liu EH, Shim J, Naruse K, Csete ME,
Thouless MD, Takayama S. (2005) Fabrication of reconfigurable protein matrices by
cracking. Nat. Mater. 4(5): 403-6.
2017. Zweckstetter M, Schnell JR, Chou JJ. (2005) Determination of the packing mode
of the coiled-coil domain of cgmp-dependent protein kinase i alpha in solution using
charge-predicted dipolar couplings. J. Am. Chem. Soc. 127(34): 11918-9.
2018. Adrian FJ, Ding Q, Sim TB, Velentza A, Sloan C, Liu Y, Zhang GB, Hur W, Ding
S, Manley P, Mestan J, Fabbro D, Gray NS. (2006) Allosteric inhibitors of bcr-abldependent
cell proliferation. Nat. Chem. Biol. 2(2): 95-102.
2019. Al-Bassam J, van Breugel M, Harrison SC, Hyman A. (2006) Stu2p binds tubulin
and undergoes an open-to-closed conformational change. J. Cell Biol. 172(7): 1009-22.
2020. Ala PJ, Gonneville L, Hillman M, Becker-Pasha M, Yue EW, Douty B, Wayland B,
Polam P, Crawley ML, McLaughlin E, Sparks RB, Glass B, Takvorian A, Combs AP,
Burn TC, Hollis GF, Wynn R. (2006) Structural insights into the design of nonpeptidic
isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1b. J. Biol. Chem.
281(49): 38013-21.
2021. Ala PJ, Gonneville L, Hillman MC, Becker-Pasha M, Wei M, Reid BG, Klabe R,
Yue EW, Wayland B, Douty B, Polam P, Wasserman Z, Bower M, Combs AP, Burn TC,
Hollis GF, Wynn R. (2006) Structural basis for inhibition of protein-tyrosine phosphatase
1b by isothiazolidinone heterocyclic phosphonate mimetics. J. Biol. Chem. 281(43):
32784-95.
2022. Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S.
(2006) Collecting and organizing systematic sets of protein data. Nat. Rev. Mol. Cell
Biol. 7(11): 803-12.
2023. Alexander JP, Cravatt BF. (2006) The putative endocannabinoid transport
blocker ly2183240 is a potent inhibitor of faah and several other brain serine
hydrolases. J. Am. Chem. Soc. 128(30): 9699-704.

2024. Alexander MD, Burkart MD, Leonard MS, Portonovo P, Liang B, Ding XB, Joullie
MM, Gulledge BM, Aggen JB, Chamberlin AR, Sandler J, Fenical W, Cui J, Gharpure
SJ, Polosukhin A, Zhang HR, Evans PA, Richardson AD, Harper MK, Ireland CM, Vong
BG, Brady TP, Theodorakis EA, La Clair JJ. (2006) A central strategy for converting
natural products into fluorescent probes. Chembiochem. 7(3): 409-16.
2025. Alexander MD, Fontaine SD, La Clair JJ, DiPasquale AG, Rheingold AL, Burkart
MD. (2006) Synthesis of the mycolactone core by ring-closing metathesis. Chem.
Commun. (44): 4602-4.
2026. Alfonso A, Vieytes MR, Ofuji K, Satake M, Nicolaou KC, Frederick MO, Botana
LM. (2006) Azaspiracids modulate intracellular ph levels in human lymphocytes.
Biochem. Biophys. Res. Commun. 346(3): 1091-9.
2027. Aliahmad P, Kaye J. (2006) Commitment issues: Linking positive selection
signals and lineage diversification in the thymus. Immunol. Rev. 209: 253-73.
2028. Alper PB, Liu H, Chatterjee AK, Nguyen KT, Tully DC, Tumanut C, Li J, Harris JL,
Tuntland T, Chang J, Gordon P, Hollenbeck T, Karanewsky DS. (2006) Arylaminoethyl
amides as noncovalent inhibitors of cathepsin s. Part 2: Optimization of p1 and n-aryl.
Bioorg. Med. Chem. Lett. 16(6): 1486-90.
2029. Alvarez D, Chou CJ, Latella L, Zeitlin SG, Ku S, Puri PL, Dervan PB, Gottesfeld
JM. (2006) A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a
polyamide-alkylator conjugate. Cell Cycle. 5(14): 1537-48.
2030. An CI, Trinh VB, Yokobayashi Y. (2006) Artificial control of gene expression in
mammalian cells by modulating rna interference through aptamer-small molecule
interaction. RNA-Publ. RNA Soc. 12(5): 710-6.
2031. Anderson JC, Clarke EJ, Arkin AP, Voigt CA. (2006) Environmentally controlled
invasion of cancer cells by engineered bacteria. J. Mol. Biol. 355(4): 619-27.
2032. Arnold LA, Guy RK. (2006) Synthesis of highly substituted dibenzo[b,f]azocines
and their evaluation as protein kinase inhibitors. Bioorg. Med. Chem. Lett. 16(20): 5360-
3.
2033. Ashkenasy N, Horne WS, Ghadiri MR. (2006) Design of self-assembling peptide
nanotubes with delocalized electronic states. Small. 2(1): 99-102.
2034. Balakrishnan A, Patel B, Sieber SA, Chen D, Pachikara N, Zhong GM, Cravatt
BF, Fan HZ. (2006) Metalloprotease inhibitors gm6001 and tapi-0 inhibit the obligate
intracellular human pathogen chlamydia trachomatis by targeting peptide deformylase of
the bacterium. J. Biol. Chem. 281(24): 16691-9.
2035. Bang ML, Li XD, Littlefield R, Bremner S, Thor A, Knowlton KU, Lieber RL, Chen
J. (2006) Nebulin-deficient mice exhibit shorter thin filament lengths and reduced
contractile function in skeletal muscle. J. Cell Biol. 173(6): 905-16.
2036. Banin E, Dorrell MI, Aguilar E, Ritter MR, Aderman CM, Smith ACH, Friedlander
J, Friedlander M. (2006) T2-trprs inhibits preretinal neovascularization and enhances
physiological vascular regrowth in oir as assessed by a new method of quantification.
Invest. Ophthalmol. Vis. Sci. 47(5): 2125-34.
2037. Banka CL, Lund CV, Nguyen MTN, Pakchoian AJ, Mueller BM, Eliceiri BP.
(2006) Estrogen induces lung metastasis through a host compartment-specific
response. Cancer Res. 66(7): 3667-72.

2038. Baran PS, Burns NZ. (2006) Total synthesis of (+/-)-haouamine a. J. Am. Chem.
Soc. 128(12): 3908-9.
2039. Baran PS, DeMartino MP. (2006) Intermolecular oxidative enolate
heterocoupling. Angew. Chem.-Int. Edit. 45(42): 7083-6.
2040. Baran PS, Hafensteiner BD, Ambhaikar NB, Guerrero CA, Gallagher JD. (2006)
Enantioselective total synthesis of avrainvillamide and the stephacidins. J. Am. Chem.
Soc. 128(26): 8678-93.
2041. Baran PS, Li K, O'Malley DP, Mitsos C. (2006) Short, enantioselective total
synthesis of sceptrin and ageliferin by programmed oxaquadricyclane fragmentation.
Angew. Chem.-Int. Edit. 45(2): 249-52.
2042. Baran PS, Shenvi RA. (2006) Total synthesis of (+/-)-chartelline c. J. Am. Chem.
Soc. 128(43): 14028-9.
2043. Baran PS, Shenvi RA, Nguyen SA. (2006) One-step synthesis of 4,5disubstituted
pyrimidines using commercially available and inexpensive reagents.
Heterocycles. 70: 581-+.
2044. Barglow KT, Cravatt BF. (2006) Substrate mimicry in an activity-based probe that
targets the nitrilase family of enzymes. Angew. Chem.-Int. Edit. 45(44): 7408-11.
2045. Barluenga S, Dakas PY, Terandin Y, Meijer L, Winssinger N. (2006) Modular
asymmetric synthesis of aigialomycin d, a kinase-inhibitory scaffold. Angew. Chem.-Int.
Edit. 45(24): 3951-4.
2046. Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva YE, Graber S, Kovacs
I, Lee WD, Waggoner J, Cui JK, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA,
Ellisman MH, Perkins GA, Bossy-Wetzel E. (2006) Nitric oxide-induced mitochondrial
fission is regulated by dynamin-related gtpases in neurons. Embo J. 25(16): 3900-11.
2047. Basavarajappa BS, Yalamanchili R, Cravatt BF, Cooper TB, Hungund BL. (2006)
Increased ethanol consumption and preference and decreased ethanol sensitivity in
female faah knockout mice. Neuropharmacology. 50(7): 834-44.
2048. Baxter IR, Borevitz JO. (2006) Mapping a plant's chemical vocabulary. Nature
Genet. 38(7): 737-8.
2049. Beck ZQ, Sherman DH. (2006) Development of an internally quenched
fluorogenic substrate for kinetic analysis of thioesterases. Anal. Biochem. 349(2): 309-
11.
2050. Belvindrah R, Nalbant P, Ding S, Wu CY, Bokoch GM, Muller U. (2006) Integrinlinked
kinase regulates bergmann glial differentiation during cerebellar development.
Mol. Cell. Neurosci. 33(2): 109-25.
2051. Berryman OB, Hof F, Hynes MJ, Johnson DW. (2006) Anion-pi interaction
augments halide binding in solution. Chem. Commun. (5): 506-8.
2052. Biastoff S, Teuber M, Zhou ZHS, Drager B. (2006) Colorimetric activity
measurement of a recombinant putrescine n-methyltransferase from datura stramonium.
Planta Med. 72(12): 1136-41.
2053. Blanco-Rodriguez AM, Busby M, Gradinaru C, Crane BR, Di Bilio AJ, Matousek
P, Towrie M, Leigh BS, Richards JH, Vlcek A, Gray HB. (2006) Excited-state dynamics
of structurally characterized [re-i(co)(3)(phen)(hisx)](+) (x=83,109) pseudomonas
aeruginosa azurins in aqueous solution. J. Am. Chem. Soc. 128(13): 4365-70.

2054. Boldt GE, Dickerson TJ, Janda KD. (2006) Emerging chemical and biological
approaches for the preparation of discovery libraries. Drug Discov. Today. 11(3-4): 143-
8.
2055. Boldt GE, Eubanks LM, Janda KD. (2006) Identification of a botulinum neurotoxin
a protease inhibitor displaying efficacy in a cellular model. Chem. Commun. (29): 3063-
5.
2056. Boldt GE, Kennedy JP, Hixon MS, McAllister LA, Barbieri JT, Tzipori S, Janda
KD. (2006) Synthesis, characterization and development of a high-throughput
methodology for the discovery of botulinum neurotoxin a inhibitors. J. Comb. Chem.
8(4): 513-21.
2057. Boldt GE, Kennedy JP, Janda KD. (2006) Identification of a potent botulinum
neurotoxin a protease inhibitor using in situ lead identification chemistry. Org. Lett. 8(8):
1729-32.
2058. Bolgunas S, Clark DA, Hanna WS, Mauvais PA, Pember SO. (2006) Potent
inhibitors of the qi site of the mitochondrial respiration complex iii. J. Med. Chem.
49(15): 4762-6.
2059. Bosco DA, Fowler DM, Zhang QH, Nieva J, Powers ET, Wentworth P, Lerner RA,
Kelly JW. (2006) Elevated levels of oxidized cholesterol metabolites in lewy body
disease brains accelerate alpha-synuclein fibrilization. Nat. Chem. Biol. 2(5): 249-53.
2060. Bose M, Groff D, Xie JM, Brustad E, Schultz PG. (2006) The incorporation of a
photoisomerizable amino acid into proteins in e-coli. J. Am. Chem. Soc. 128(2): 388-9.
2061. Brigl M, van den Elzen P, Chen X, Meyers JH, Wu D, Wong CH, Reddington F,
Illarianov PA, Besra GS, Brenner MB, Gumperz JE. (2006) Conserved and
heterogeneous lipid antigen specificities of cd1d-restricted nkt cell receptors. J.
Immunol. 176(6): 3625-34.
2062. Brik A, Ficht S, Yang YY, Bennett CS, Wong CH. (2006) Sugar-assisted ligation
of n-linked glycopeptides with broad sequence tolerance at the ligation junction. J. Am.
Chem. Soc. 128(46): 15026-33.
2063. Brik A, Yang YY, Ficht S, Wong CH. (2006) Sugar-assisted glycopeptide ligation.
J. Am. Chem. Soc. 128(17): 5626-7.
2064. Brogan AP, Dickerson TJ, Janda KD. (2006) Enamine-based aldol
organocatalysis in water: Are they really "All wet"? Angew. Chem.-Int. Edit. 45(48):
8100-2.
2065. Brunel FM, Zwick MB, Cardoso RMF, Nelson JD, Wilson IA, Burton DR, Dawson
PE. (2006) Structure-function analysis of the epitope for 4e10, a broadly neutralizing
human immunodeficiency virus type 1 antibody. J. Virol. 80(4): 1680-7.
2066. Bukau B, Weissman J, Horwich A. (2006) Molecular chaperones and protein
quality control. Cell. 125(3): 443-51.
2067. Burstein ES, Piu F, Ma JN, Weissman JT, Currier EA, Nash NR, Weiner DM,
Spalding TA, Schiffer HH, Del Tredici AL, Brann MR. (2006) Integrative functional
assays, chemical genomics and high throughput screening: Harnessing signal
transduction pathways to a common hts readout. Curr. Pharm. Design. 12(14): 1717-29.
2068. Calderon AJ, Heo YS, Huh D, Futai N, Takayama S, Fowlkes JB, Bull JL. (2006)
Microfluidic model of bubble lodging in microvessel bifurcations. Appl. Phys. Lett.

89(24): 3.
2069. Caligiuri MP, Brown GG, Meloy MJ, Eberson S, Niculescu AB, Lohr JB. (2006)
Striatopallidal regulation of affect in bipolar disorder. J. Affect. Disord. 91(2-3): 235-42.
2070. Call ME, Schnell JR, Xu CQ, Lutz RA, Chou JJ, Wucherpfennig KW. (2006) The
structure of the zeta zeta transmembrane dimer reveals features essential for its
assembly with the t cell receptor. Cell. 127(2): 355-68.
2071. Cao Y, Kumar RM, Penn BH, Berkes CA, Kooperberg C, Boyer LA, Young RA,
Tapscott SJ. (2006) Global and gene-specific analyses show distinct roles for myod and
myog at a common set of promoters. Embo J. 25(3): 502-11.
2072. Cardenas WB, Loo YM, Gale M, Hartman AL, Kimberlin CR, Martinez-Sobrido L,
Saphire EO, Basler CF. (2006) Ebola virus vp35 protein binds double-stranded rna and
inhibits alpha/beta interferon production induced by rig-i signaling. J. Virol. 80(11): 5168-
78.
2073. Cassidy MP, Raushel J, Fokin VV. (2006) Practical synthesis of amides from in
situ generated copper(i) acetylides and sulfonyl azides. Angew. Chem.-Int. Edit. 45(19):
3154-7.
2074. Castanedo G, Clark K, Wang SM, Tsui V, Wong ML, Nicholas J, Wickramasinghe
D, Marsters JC, Sutherlin D. (2006) Cdk2/cyclina inhibitors: Targeting the cyclina
recruitment site with small molecules derived from peptide leads. Bioorg. Med. Chem.
Lett. 16(6): 1716-20.
2075. Chai Q, Arndt JW, Dong M, Tepp WH, Johnson EA, Chapman ER, Stevens RC.
(2006) Structural basis of cell surface receptor recognition by botulinum neurotoxin b.
Nature. 444(7122): 1096-100.
2076. Chao XJ, Muff TJ, Park SY, Zhang S, Pollard AM, Ordal GW, Bilwes AM, Crane
BR. (2006) A receptor-modifying deamidase in complex with a signaling phosphatase
reveals reciprocal regulation. Cell. 124(3): 561-71.
2077. Chapman E, Farr GW, Usaite R, Furtak K, Fenton WA, Chaudhuri TK, Hondorp
ER, Matthews RG, Wolf SG, Yates JR, Pypaert M, Horwich AL. (2006) Global
aggregation of newly translated proteins in an escherichia coli strain deficient of the
chaperonin groel. Proc. Natl. Acad. Sci. U. S. A. 103(43): 15800-5.
2078. Chatterji U, Bobardt MD, Gaskill P, Sheeter D, Fox H, Gallay PA. (2006) Trim5
alpha accelerates degradation of cytosolic capsid associated with productive hiv-1 entry.
J. Biol. Chem. 281(48): 37025-33.
2079. Cheeseman IM, Chappie JS, Wilson-Kubalek EM, Desai A. (2006) The
conserved kmn network constitutes the core microtubule-binding site of the kinetochore.
Cell. 127(5): 983-97.
2080. Chen Q, Higgs RE, Vieth M. (2006) Geometric accuracy of three-dimensional
molecular overlays. J. Chem Inf. Model. 46(5): 1996-2002.
2081. Chen SB, Do JT, Zhang QS, Yao SY, Yan F, Peters EC, Scholer HR, Schultz PG,
Ding S. (2006) Self-renewal of embryonic stem cells by a small molecule. Proc. Natl.
Acad. Sci. U. S. A. 103(46): 17266-71.
2082. Chen SB, Hilcove S, Ding S. (2006) Exploring stem cell biology with small
molecules. Mol. Biosyst. 2(1): 18-24.
2083. Cheng SC, Yang WB, Chin SW, Lin CC, Lin CH, Chen YJ, Lin PC, Wu MF, Wong

CH, Hsieh SL. (2006) Profiling of polysaccharide - receptor interaction with recombinant
innate immunity receptor-fc fusion proteins. Glycobiology. 16(11): 147.
2084. Cheng YSE, Lo KH, Hsu HH, Shao YM, Yang WB, Lin CH, Wong CH. (2006)
Screening for hiv protease inhibitors by protection against activity-mediated cytotoxicity
in escherichia coli. J. Virol. Methods. 137(1): 82-7.
2085. Chiang KP, Niessen S, Saghatelian A, Cravatt BF. (2006) An enzyme that
regulates ether lipid signaling pathways in cancer annotated by multidimensional
profiling. Chem. Biol. 13(10): 1041-50.
2086. Cirz RT, Gingles N, Romesberg FE. (2006) Side effects may include evolution.
Nat. Med. 12(8): 890-1.
2087. Cirz RT, O'Neill BM, Hammond JA, Head SR, Romesberg FE. (2006) Defining
the pseudomonas aeruginosa sos response and its role in the global response to the
antibiotic ciprofloxacin. J. Bacteriol. 188(20): 7101-10.
2088. Cirz RT, Romesberg FE. (2006) Induction and inhibition of ciprofloxacin
resistance-conferring mutations in hypermutator bacteria. Antimicrob. Agents
Chemother. 50(1): 220-5.
2089. Clark J, Ding S. (2006) Generation of rnai libraries for high-throughput screens. J.
Biomed. Biotechnol.: 7.
2090. Clark RC, Pfeiffer SS, Boger DL. (2006) Diastereoselective diels-alder reactions
of n-sulfonyl-1-aza-1,3-butadienes with optically active enol ethers: An asymmetric
variant of the 1-azadiene diels-alder reaction. J. Am. Chem. Soc. 128(8): 2587-93.
2091. Clark TD, Dugan EC. (2006) Preparation of oligo(ethylene glycol)-terminated
icosanedisulfides. Synthesis. (7): 1083-6.
2092. Clark TD, Sastry M, Brown C, Wagner G. (2006) Solid-phase synthesis of
backbone-cyclized beta-helical peptides. Tetrahedron. 62(41): 9533-40.
2093. Collins CS, Hong JY, Sapinoso L, Zhou YY, Liu Z, Micklash K, Schultz PG,
Hampton GM. (2006) A small interfering rna screen for modulators of tumor cell motility
identifies map4k4 as a promigratory kinase. Proc. Natl. Acad. Sci. U. S. A. 103(10):
3775-80.
2094. Combs AP, Zhu WY, Crawley ML, Glass B, Polam P, Sparks RB, Modi D,
Takvorian A, McLaughlin E, Yue EW, Wasserman Z, Bower M, Wei M, Rupar M, Ala PJ,
Reid BM, Ellis D, Gonneville L, Emm T, Taylor N, Yeleswaram S, Li YL, Wynn R, Burn
TC, Hollis G, Liu PCC, Metcalf B. (2006) Potent benzimidazole sulfonamide protein
tyrosine phosphatase 1b inhibitors containing the heterocyclic (s)-isothiazolidinone
phosphotyrosine mimetic. J. Med. Chem. 49(13): 3774-89.
2095. Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM,
Larsen NA, Wilson IA, Landry DW, Woods JH. (2006) Rapid and robust protection
against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol.
Pharmacol. 70(6): 1885-91.
2096. Cremeens ME, Fujisaki H, Zhang Y, Zimmermann J, Sagle LB, Matsuda S,
Dawson PE, Straub JE, Romesberg FE. (2006) Efforts toward developing direct probes
of protein dynamics. J. Am. Chem. Soc. 128(18): 6028-9.
2097. Crowley BM, Boger DL. (2006) Total synthesis and evaluation of
[psi[ch2nh]tpg(4)]vancomycin aglycon: Reengineering vancomycin for dual d-ala-d-ala

and d-ala-d-lac binding. J. Am. Chem. Soc. 128(9): 2885-92.
2098. Dale TJ, Rebek J. (2006) Fluorescent sensors for organophosphorus nerve agent
mimics. J. Am. Chem. Soc. 128(14): 4500-1.
2099. De Haro L, Panda S. (2006) Systems biology of circadian rhythms: An outlook. J.
Biol. Rhythms. 21(6): 507-18.
2100. Deechongkit S, Aoki KH, Park SS, Kerwin BA. (2006) Biophysical comparability
of the same protein from different manufacturers: A case study using epoetin alfa from
epogen (r) and eprex (r). J. Pharm. Sci. 95(9): 1931-43.
2101. Deechongkit S, Nguyen H, Jager M, Powers ET, Gruebele M, Kelly JW. (2006)
Beta-sheet folding mechanisms from perturbation energetics. Curr. Opin. Struct. Biol.
16(1): 94-101.
2102. Deiters A, Groff D, Ryu YH, Xie JM, Schultz PG. (2006) A genetically encoded
photocaged tyrosine. Angew. Chem.-Int. Edit. 45(17): 2728-31.
2103. Delehanty JB, Medintz IL, Pons T, Brunel FM, Dawson PE, Mattoussi H. (2006)
Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery.
Bioconjugate Chem. 17(4): 920-7.
2104. DeMartino JK, Hwang I, Xu L, Wilson IA, Boger DL. (2006) Discovery of a potent,
nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. J. Med.
Chem. 49(10): 2998-3002.
2105. Dias DP, Marenco RA. (2006) Photoinhibition of photosynthesis in minquartia
guianensis and swietenia macrophylla inferred by monitoring the initial fluorescence.
Photosynthetica. 44(2): 235-40.
2106. Diaz DD, Converso A, Sharpless KB, Finn MG. (2006) 296-dichloro-9thiabicyclo[3.3.1]nonane:
Multigram display of azide and cyanide components on a
versatile scaffold. Molecules. 11(4): 212-8.
2107. Diaz DD, Rajagopal K, Strable E, Schneider J, Finn MG. (2006) "Click" Chemistry
in a supramolecular environment: Stabilization of organogels by copper(i)-catalyzed
azide-alkyne [3+2] cycloaddition. J. Am. Chem. Soc. 128(18): 6056-7.
2108. Dickerson TJ, Janda KD. (2006) The use of small molecules to investigate
molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin a
intoxication. ACS Chem. Biol. 1(6): 359-69.
2109. Dirksen A, Dirksen S, Hackeng TM, Dawson PE. (2006) Nucleophilic catalysis of
hydrazone formation and transimination: Implications for dynamic covalent chemistry. J.
Am. Chem. Soc. 128(49): 15602-3.
2110. Dirksen A, Hackeng TM, Dawson PE. (2006) Nucleophilic catalysis of oxime
ligation. Angew. Chem.-Int. Edit. 45(45): 7581-4.
2111. Dong H, Hartgerink JD. (2006) Short homodimeric and heterodimeric coiled coils.
Biomacromolecules. 7(3): 691-5.
2112. Dorgan KM, Wooderchak WL, Wynn DP, Karschner EL, Alfaro JF, Cui YQ, Zhou
ZS, Hevel JM. (2006) An enzyme-coupled continuous spectrophotometric assay for sadenosylmethionine-dependent
methyltransferases. Anal. Biochem. 350(2): 249-55.
2113. Dorrell MI, Friedlander M. (2006) Mechanisms of endothelial cell guidance and
vascular patterning in the developing mouse retina. Prog. Retin. Eye Res. 25(3): 277-
95.

2114. Dunia I, Cibert C, Gong XH, Xia CH, Recouvreur M, Levy E, Kumar N,
Bloemendal H, Benedetti EL. (2006) Structural and immunocytochemical alterations in
eye lens fiber cells from cx46 and cx50 knockout mice. Eur. J. Cell Biol. 85(8): 729-52.
2115. Dyck B, Markison S, Zhao LR, Tamiya J, Grey J, Rowbottom MW, Zhang MZ,
Vickers T, Sorensen K, Norton C, Wen J, Heise CE, Saunders J, Conlon P, Madan A,
Schwarz D, Goodfellow VS. (2006) A thienopyridazinone-based melanin-concentrating
hormone receptor 1 antagonist with potent in vivo anorectic properties. J. Med. Chem.
49(13): 3753-6.
2116. Dyck B, Zhao L, Tamiya J, Pontillo J, Hudson S, Ching B, Heise CE, Wen J,
Norton C, Madan A, Schwarz D, Wade W, Goodfellow VS. (2006) Substituted
chromones and quinolones as potent melanin-concentrating hormone receptor 1
antagonists. Bioorg. Med. Chem. Lett. 16(16): 4237-42.
2117. Elliott GI, Fuchs JR, Blagg BSJ, Ishikawa H, Tao HC, Yuan ZQ, Boger DL. (2006)
Intramolecular diels alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles. J. Am.
Chem. Soc. 128(32): 10589-95.
2118. Etezady-Esfarjani T, Placzek WJ, Herrmann T, Wuthrich K. (2006) Solution
structures of the putative anti-sigma-factor antagonist tm1442 from thermotoga maritima
in the free and phosphorylated states. Magn. Reson. Chem. 44: S61-S70.
2119. Eubanks LM, Rogers CJ, Beuscher AE, Koob GF, Olson AJ, Dickerson TJ,
Janda KD. (2006) A molecular link between the active component of marijuana and
alzheimer's disease pathology. Mol. Pharm. 3(6): 773-7.
2120. Evan-Salem T, Baruch I, Avram L, Cohen Y, Palmer LC, Rebek J. (2006)
Resorcinarenes are hexameric capsules in solution. Proc. Natl. Acad. Sci. U. S. A.
103(33): 12296-300.
2121. Evans MJ, Cravatt BF. (2006) Mechanism-based profiling of enzyme families.
Chem. Rev. 106(8): 3279-301.
2122. Fahr BT, O'Brien T, Pham P, Waal ND, Baskaran S, Raimundo BC, Lam JW,
Sopko MM, Purkey HE, Romanowski MJ. (2006) Tethering identifies fragment that
yields potent inhibitors of human caspase-1. Bioorg. Med. Chem. Lett. 16(3): 559-62.
2123. Fowler DM, Koulov AV, Alory-Jost C, Marks MS, Balch WE, Kelly JW. (2006)
Functional amyloid formation within mammalian tissue. PLoS. Biol. 4(1): 100-7.
2124. Fraley ME, Garbaccio RM, Arrington KL, Hoffman WF, Tasber ES, Coleman PJ,
Buser CA, Walsh ES, Hamilton K, Fernandes C, Schaber MD, Lobell RB, Tao WK,
South VJ, Yan YW, Kuo LC, Prueksaritanont T, Shu C, Torrent M, Heimbrook DC, Kohl
NE, Huber HE, Hartman GD. (2006) Kinesin spindle protein (ksp) inhibitors. Part 2: The
design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the
mitotic kinesin ksp. Bioorg. Med. Chem. Lett. 16(7): 1775-9.
2125. Friker J, Dias DP, Zeiler E. (2006) Breeds-based differences in age determination
in thoroughbred, arab, trotter and belgian draft. Wien. Tierarz. Monats. 93(9-10): 218-
25.
2126. Frosst P, Wattendorf DJ. (2006) At-home genetic tests. Am. Fam. Physician.
73(3): 540-1.
2127. Frueh DP, Sun ZYJ, Vosburg DA, Walsh CT, Hoch JC, Wagner G. (2006) Nonuniformly
sampled double-trosy hncanh experiments for nmr sequential assignments of

large proteins. J. Am. Chem. Soc. 128(17): 5757-63.
2128. Frueh DP, Vosburg DA, Walsh CT, Wagner G. (2006) Determination of all noes
in h-1-c-13-me-ilv-u-h-2-n-15 proteins with two time-shared experiments. J. Biomol.
NMR. 34(1): 31-40.
2129. Fu ZJ, Chen S, Baldwin MR, Boldt GE, Crawford A, Janda KD, Barbieri JT, Kim
JJP. (2006) Light chain of botulinum neurotoxin serotype a: Structural resolution of a
catalytic intermediate. Biochemistry. 45(29): 8903-11.
2130. Futai N, Gu W, Song JW, Takayama S. (2006) Handheld recirculation system
and customized media for microfluidic cell culture. Lab Chip. 6(1): 149-54.
2131. Gan L, Speir JA, Conway JF, Lander G, Cheng NQ, Firek BA, Hendrix RW, Duda
RL, Liljas L, Johnson JE. (2006) Capsid conformational sampling in hk97 maturation
visualized by x-ray crystallography and cryo-em. Structure. 14(11): 1655-65.
2132. Garbaccio RM, Fraley ME, Tasber ES, Olson CM, Hoffman WF, Arrington KL,
Torrent M, Buser CA, Walsh ES, Hamilton K, Schaber MD, Fernandes C, Lobell RB,
Tao WK, South VJ, Yan YW, Kuo LC, Prueksaritanont T, Slaughter DE, Shu C,
Heimbrook DC, Kohl NE, Huber HE, Hartman GD. (2006) Kinesin spindle protein (ksp)
inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles
with reduced herg binding and employment of a phosphate prodrug strategy for
aqueous solubility. Bioorg. Med. Chem. Lett. 16(7): 1780-3.
2133. Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ. (2006) Polycomb group
and scf ubiquitin ligases are found in a novel bcor complex that is recruited to bcl6
targets. Mol. Cell. Biol. 26(18): 6880-9.
2134. Gerdts CJ, Tereshko V, Yadav MK, Dementieva I, Collart F, Joachimiak A,
Stevens RC, Kuhn P, Kossiakoff A, Ismagilov RF. (2006) Time-controlled microfluidic
seeding in nl-volume droplets to separate nucleation and growth stages of protein
crystallization. Angew. Chem.-Int. Edit. 45(48): 8156-60.
2135. Gong Y, Luo YM, Bong D. (2006) Membrane activation: Selective vesicle fusion
via small molecule recognition. J. Am. Chem. Soc. 128(45): 14430-1.
2136. Gordus A, MacBeath G. (2006) Circumventing the problems caused by protein
diversity in microarrays: Implications for protein interaction networks. J. Am. Chem. Soc.
128(42): 13668-9.
2137. Gosgnach S, Lanuza GM, Butt SJB, Saueressig H, Zhang Y, Velasquez T,
Riethmacher D, Callaway EM, Kiehn O, Goulding M. (2006) V1 spinal neurons regulate
the speed of vertebrate locomotor outputs. Nature. 440(7081): 215-9.
2138. Gradinaru C, Crane BR. (2006) Comparison of intra- vs intermolecular long-range
electron transfer in crystals of ruthenium-modified azurin. J. Phys. Chem. B. 110(41):
20073-6.
2139. Grant SW, Zhu KD, Zhang Y, Castle SL. (2006) Stereloselective cascade
reactions that incorporate a 7-exo acyl radical cyclization. Org. Lett. 8(9): 1867-70.
2140. Grosshans BL, Andreeva A, Gangar A, Niessen S, Yates JR, Brennwald P,
Novick P. (2006) The yeast igi family member sro7p is an effector of the secretory rab
gtpase sec4p. J. Cell Biol. 172(1): 55-66.
2141. Gruber A, Fernandez JA, Bush L, Marzec U, Griffin JH, Hanson SR, Di Cera E.
(2006) Limited generation of activated protein c during infusion of the protein c activator

thrombin analog w215a/e217a in primates. J. Thromb. Haemost. 4(2): 392-7.
2142. Gupton SL, Waterman-Storer CM. (2006) Spatiotemporal feedback between
actomyosin and focal-adhesion systems optimizes rapid cell migration. Cell. 125(7):
1361-74.
2143. Guvench O, MacKerell AD. (2006) Quantum mechanical analysis of 1,2ethanediol
conformational energetics and hydrogen bonding. J. Phys. Chem. A.
110(32): 9934-9.
2144. Hadnagy A, Gaboury L, Beaulieu R, Balicki D. (2006) Sp analysis may be used to
identify cancer stem cell populations. Exp. Cell Res. 312(19): 3701-10.
2145. Hanson SR, Whalen LJ, Wong CH. (2006) Synthesis and evaluation of general
mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and
cyclic phenyl sulfamate motifs. Bioorg. Med. Chem. 14(24): 8386-95.
2146. Hartgerink JD. (2006) Nanomedicine - new material stops bleeding in a hurry.
Nat. Nanotechnol. 1(3): 166-7.
2147. Hayden AE, Xu H, Nicolaou KC, Houk KN. (2006) Origins of selectivity in
pericyclic reaction cascades for the synthesis of gambogin and lateriflorone. Org. Lett.
8(14): 2989-92.
2148. He LW, Yang LP, Castle SL. (2006) Synthesis of the celogentin c right-hand ring.
Org. Lett. 8(6): 1165-8.
2149. Hof F, Schutz A, Fah C, Meyer S, Bur D, Liu J, Goldberg DE, Diederich F. (2006)
Starving the malaria parasite: Inhibitors active against the aspartic proteases
plasmepsins i, ii, and iv. Angew. Chem.-Int. Edit. 45(13): 2138-41.
2150. Hooley RJ, Biros SM, Rebek J. (2006) A deep, water-soluble cavitand acts as a
phase-transfer catalyst for hydrophobic species. Angew. Chem.-Int. Edit. 45(21): 3517-
9.
2151. Hooley RJ, Biros SM, Rebek J. (2006) Normal hydrocarbons tumble rapidly in a
deep, water-soluble cavitand. Chem. Commun. (5): 509-10.
2152. Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst SJ,
Dunne JC, Dietz GPH, Bahr M, McDunn JE, Karl IE, Wagner TH, Cobb JP, Coopersmith
CM, Piwnica-Worms D. (2006) Tat-bh4 and tat-bcl-x(l) peptides protect against sepsisinduced
lymphocyte apoptosis in vivo. J. Immunol. 176(9): 5471-7.
2153. Huang CY, Thayer DA, Chang AY, Best MD, Hoffmann J, Head S, Wong CH.
(2006) Carbohydrate microarray for profiling the antibodies interacting with globo h
tumor antigen. Proc. Natl. Acad. Sci. U. S. A. 103(1): 15-20.
2154. Huang KT, Wu BC, Lin CC, Luo SC, Chen CP, Wong CH. (2006) Multi-enzyme
one-pot strategy for the synthesis of sialyl lewis x-containing psgl-1 glycopeptide.
Carbohydr. Res. 341(12): 2151-5.
2155. Huang SE, Garbaccio RM, Fraley ME, Steen J, Kreatsoulas C, Hartman G,
Stirdivant S, Drakas B, Rickert K, Walsh E, Hamilton K, Buser CA, Hardwick J, Mao XZ,
Abrams M, Beck S, Tao WK, Lobell R, Sepp-Lorenzino L, Yan YW, Ikuta M, Murphy JZ,
Sardana V, Munshi S, Kuo L, Reilly M, Mahan E. (2006) Development of 6-substituted
indolylquinolinones as potent chek 1 kinase inhibitors. Bioorg. Med. Chem. Lett. 16(22):
5907-12.
2156. Iancu CV, Tivol WF, Schooler JB, Dias DP, Henderson GP, Murphy GE, Wright

ER, Li Z, Yu ZH, Briegel A, Gan L, He YN, Jensen GJ. (2006) Electron cryotomography
sample preparation using the vitrobot. Nat. Protoc. 1(6): 2813-9.
2157. Ito E, Frederick MO, Koftis TV, Tang WJ, Petrovic G, Ling TT, Nicolaou KC.
(2006) Structure toxicity relationships of synthetic azaspiracid-1 and analogs in mice.
Harmful Algae. 5(5): 586-91.
2158. Ivanov I, Chapados BR, McCammon JA, Tainer JA. (2006) Proliferating cell
nuclear antigen loaded onto double-stranded DNA: Dynamics, minor groove interactions
and functional implications. Nucleic Acids Res. 34(20): 6023-33.
2159. Jager M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman ME, Noel JP,
Gruebele M, Kelly JW. (2006) Structure-function-folding relationship in a ww domain.
Proc. Natl. Acad. Sci. U. S. A. 103(28): 10648-53.
2160. Jaqaman K, Dorn JF, Jelson GS, Tytell JD, Sorger PK, Danuser G. (2006)
Comparative autoregressive moving average analysis of kinetochore microtubule
dynamics in yeast. Biophys. J. 91(6): 2312-25.
2161. Jiang T, Kuhen KL, Wolff K, Yin H, Bieza K, Caldwell J, Bursulaya B, Wu TYH,
He Y. (2006) Design, synthesis and biological evaluations of novel oxindoles as hiv-1
non-nucleoside reverse transcriptase inhibitors. Part i. Bioorg. Med. Chem. Lett. 16(8):
2105-8.
2162. Jones RB, Gordus A, Krall JA, MacBeath G. (2006) A quantitative protein
interaction network for the erbb receptors using protein microarrays. Nature. 439(7073):
168-74.
2163. Jones SB, He LW, Castle SL. (2006) Total synthesis of (+/-)-hasubanonine. Org.
Lett. 8(17): 3757-60.
2164. Jontes JD, Phillips GR. (2006) Selective stabilization and synaptic specificity: A
new cell-biological model. Trends Neurosci. 29(4): 186-91.
2165. Joseph JS, Saikatendu KS, Subramanian V, Neuman BW, Brooun A, Griffith M,
Moy K, Yadav MK, Velasquez J, Buchmeier MJ, Stevens RC, Kuhn P. (2006) Crystal
structure of nonstructural protein 10 from the severe acute respiratory syndrome
coronavirus reveals a novel fold with two zinc-binding motifs. J. Virol. 80(16): 7894-901.
2166. Jun HW, Paramonov SE, Hartgerink JD. (2006) Biomimetic self-assembled
nanofibers. Soft Matter. 2(3): 177-81.
2167. Kang SA, Hoke KR, Crane BR. (2006) Solvent isotope effects on interfacial
protein electron transfer in crystals and electrode films. J. Am. Chem. Soc. 128(7):
2346-55.
2168. Kaouass M, Beaulieu R, Balicki D. (2006) Histonefection: Novel and potent nonviral
gene delivery. J. Controlled Release. 113(3): 245-54.
2169. Kaufmann GF, Sartorio R, Lee SH, Mee JM, Altobell LJ, Kujawa DP, Jeffries E,
Clapham B, Meijler MM, Janda KD. (2006) Antibody interference with n-acyl homoserine
lactone-mediated bacterial quorum sensing. J. Am. Chem. Soc. 128(9): 2802-3.
2170. Kearney AM, Vanderwal CD. (2006) Synthesis of nitrogen heterocycles by the
ring opening of pyridinium salts. Angew. Chem.-Int. Edit. 45(46): 7803-6.
2171. Kelker MS, Peti W. (2006) Nmr assignment of the spinophilin pdz domain (493-
602). J. Biomol. NMR. 36: 24-.
2172. Khaing ZZ, Fidler L, Nandy N, Phillips GR. (2006) Structural stabilization of cns

synapses during postnatal development in rat cortex. J. Neurochem. 98(2): 471-80.
2173. Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou YY, Johnson JR, Le
Roch KG, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. (2006) A
systematic map of genetic variation in plasmodium falciparum. PLoS Pathog. 2(6): 562-
77.
2174. Kim Y, Lillo AM, Steiniger SCJ, Liu Y, Ballatore C, Anichini A, Mortarini R,
Kaufmann GF, Zhou B, Felding-Habermann B, Janda KD. (2006) Targeting heat shock
proteins on cancer cells: Selection, characterization, and cell-penetrating properties of a
peptidic grp78 ligand. Biochemistry. 45(31): 9434-44.
2175. Kinjo Y, Tupin E, Wu D, Fujio M, Garcia-Navarro R, Benhnia M, Zajonc DM, Ben-
Menachem G, Ainge GD, Painter GF, Khurana A, Hoebe K, Behar SM, Beutler B,
Wilson IA, Tsuji M, Sellati TJ, Wong CH, Kronenberg M. (2006) Natural killer t cells
recognize diacylglycerol antigens from pathogenic bacteria. Nat. Immunol. 7(9): 978-86.
2176. Komori H, Meehar TF, Havran WL. (2006) Epithelial and mucosal gamma delta t
cells. Curr. Opin. Immunol. 18(5): 534-8.
2177. Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Wood MR,
Brogan AP, Lehmann M, Mee JM, Iwata K, Pan Q, Fearns C, Knaus UG, Meijler MM,
Janda KD, Ulevitch RJ. (2006) N-(3-oxo-acyl)homoserine lactones signal cell activation
through a mechanism distinct from the canonical pathogen-associated molecular pattern
recognition receptor pathways. J. Biol. Chem. 281(39): 28822-30.
2178. La Clair JJ, Burkart MD. (2006) Geometry in digital molecular arrays. Org.
Biomol. Chem. 4(16): 3052-5.
2179. Lam MT, Sim S, Zhu XY, Takayama S. (2006) The effect of continuous wavy
micropatterns on silicone substrates on the alignment of skeletal muscle myoblasts and
myotubes. Biomaterials. 27(24): 4340-7.
2180. Landen CN, Lu C, Han LY, Coffman KT, Bruckheimer E, Halder J, Mangala LS,
Merritt WM, Lin YG, Gao C, Schmandt R, Kamat AA, Li Y, Thaker P, Gershenson DM,
Parikh NU, Gallick GE, Kinch MS, Sood AK. (2006) Efficacy and antivascular effects of
epha2 reduction with an agonistic antibody in ovarian cancer. J. Natl. Cancer Inst.
98(21): 1558-70.
2181. Larsen NA, Lin H, Wei R, Fischbach MA, Walsh CT. (2006) Structural
characterization of enterobactin hydrolase iroe. Biochemistry. 45(34): 10184-90.
2182. Laurie NA, Donovan SL, Shih CS, Zhang JK, Mills N, Fuller C, Teunisse A, Lam
S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz
S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA. (2006) Inactivation of
the p53 pathway in retinoblastoma. Nature. 444(7115): 61-6.
2183. Lawhorn BG, Boga SB, Wolkenberg SE, Boger DL. (2006) Total synthesis of
cytostatin. Heterocycles. 70: 65-+.
2184. Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR,
Amable L, Honkanen RE, Boger DL. (2006) Total synthesis and evaluation of cytostatin,
its c10-c11 diastereomers, and additional key analogues: Impact on pp2a inhibition. J.
Am. Chem. Soc. 128(51): 16720-32.
2185. Lebwohl M, Thompson EHZ. (2006) The evolution of dermatologic therapeutics:
Current uses of etanercept in psoriasis and other dermatoses - introduction. J. Am.

Acad. Dermatol. 54(3): S65-S6.
2186. Lee JW, Beebe K, Nangle LA, Jang JS, Longo-Guess CM, Cook SA, Davisson
MT, Sundberg JP, Schimmel P, Ackerman SL. (2006) Editing-defective trna synthetase
causes protein misfolding and neurodegeneration. Nature. 443(7107): 50-5.
2187. Lee JW, Lee JS, Kang M, Su AI, Chang YT. (2006) Visual artificial tongue for
quantitative metal-cation analysis by an off-the-shelf dye array. Chem.-Eur. J. 12(22):
5691-6.
2188. Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B,
Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP,
Yuan BB, Bell GW, Herbolsheimer E, Hannett NM, Sun KM, Odom DT, Otte AP, Volkert
TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA. (2006) Control of
developmental regulator's by polycomb in human embryonic stem cells. Cell. 125(2):
301-13.
2189. Leman LJ, Orgel LE, Ghadiri MR. (2006) Amino acid dependent formation of
phosphate anhydrides in water mediated by carbonyl sulfide. J. Am. Chem. Soc. 128(1):
20-1.
2190. Leung D, Saghatelian A, Simon GM, Cravatt BF. (2006) Inactivation of n-acyl
phosphatidylethanolamine phospholipase d reveals multiple mechanisms for the
biosynthesis of endocannabinoids. Biochemistry. 45(15): 4720-6.
2191. Levin CS, Janesko BG, Bardhan R, Scuseria GE, Hartgerink JD, Halas NJ.
(2006) Chain-length-dependent vibrational resonances in alkanethiol self-assembled
monolayers observed on plasmonic nanoparticle substrates. Nano Lett. 6(11): 2617-21.
2192. Liang FS, Brik A, Lin YC, Elder JH, Wong CH. (2006) Epoxide opening in water
and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates. Bioorg.
Med. Chem. 14(4): 1058-62.
2193. Liang FS, Greenberg WA, Hammond JA, Hoffmann J, Head SR, Wong CH.
(2006) Evaluation of rna-binding specificity of aminoglycosides with DNA microarrays.
Proc. Natl. Acad. Sci. U. S. A. 103(33): 12311-6.
2194. Lindsley CW, Shipe WD, Wolkenberg SE, Theberge CR, Williams DL, Sur C,
Kinney GG. (2006) Progress towards validating the nmda receptor hypofunction
hypothesis of schizophrenia. Curr. Top. Med. Chem. 6(8): 771-85.
2195. Lindsley CW, Wolkenberg SE, Kinney GG. (2006) Progress in the preparation
and testing of glycine transporter type-1 (glyt1) inhibitors. Curr. Top. Med. Chem. 6(17):
1883-96.
2196. Lis ET, Romesberg FE. (2006) Role of doa1 in the saccharomyces cerevisiae
DNA damage response. Mol. Cell. Biol. 26(11): 4122-33.
2197. Liu F, Feuer R, Hassett DE, Whitton JL. (2006) Peptide vaccination of mice
immune to lcmv or vaccinia virus causes serious cd8(+) t cell-mediated, tnf-dependent
immunopathology. J. Clin. Invest. 116(2): 465-75.
2198. Liu HT, Wong CH. (2006) Characterization of a transglycosylase domain of
streptococcus pneumoniae pbp1b. Bioorg. Med. Chem. 14(21): 7187-95.
2199. Lobell M, Hendrix M, Hinzen B, Keldenich J, Meier H, Schmeck C, Schohe-Loop
R, Wunberg T, Hillisch A. (2006) In silico admet traffic lights as a tool for the
prioritization of hts hits. ChemMedChem. 1(11): 1229-36.

2200. Lu F, Chi SW, Kim DH, Han KH, Kuntz ID, Guy RK. (2006) Proteomimetic
libraries: Design, synthesis, and evaluation of p53-mdm2 interaction inhibitors. J. Comb.
Chem. 8(3): 315-25.
2201. Lund CV, Nguyen MTN, Owens RC, Pakchoian AJ, Shaterian A, Kruse CA,
Eliceiri BP. (2006) Reduced glioma infiltration in src-deficient mice. J. Neuro-Oncol.
78(1): 19-29.
2202. Ma B, Litvinov DN, Srikanth GSC, Castle SL. (2006) Use of nitro chemistry to
synthesize unusual peptides: Application to the left-hand segment of celogentin c.
Synthesis. (19): 3291-4.
2203. Ma HZ, Zhou B, Kim Y, Janda KD. (2006) A cyclic peptide-polymer probe for the
detection of clostridium botulinum neurotoxin serotype a. Toxicon. 47(8): 901-8.
2204. Macpherson LJ, Hwang SW, Miyamoto T, Dubin AE, Patapoutian A, Story GM.
(2006) More than cool: Promiscuous relationships of menthol and other sensory
compounds. Mol. Cell. Neurosci. 32(4): 335-43.
2205. Madsen MA, Deryugina EI, Niessen S, Cravatt BF, Quigley JP. (2006) Activitybased
protein profiling implicates urokinase activation as a key step in human
fibrosarcoma intravasation. J. Biol. Chem. 281(23): 15997-6005.
2206. Magarvey NA, Beck ZQ, Golakoti T, Ding YS, Huber U, Hemscheidt TK, Abelson
D, Moore RE, Sherman DH. (2006) Biosynthetic characterization and chemoenzymatic
assembly of the cryptophycins. Potent anticancer agents from nostoc cyanobionts. ACS
Chem. Biol. 1(12): 766-79.
2207. Maginnis MS, Forrest JC, Kopecky-Bromberg SA, Dickeson SK, Santoro SA,
Zutter MM, Nemerow GR, Bergelson JM, Dermody TS. (2006) Beta 1 integrin mediates
internalization of mammalian reovirus. J. Virol. 80(6): 2760-70.
2208. Martina Y, Marcucci KT, Cherqui S, Szabo A, Drysdale T, Srinivisan U, Wilson
CA, Patience C, Salomon DR. (2006) Mice transgenic for a human porcine endogenous
retrovirus receptor are susceptible to productive viral infection. J. Virol. 80(7): 3135-46.
2209. Matsuda S, Henry AA, Romesberg FE. (2006) Optimization of unnatural base
pair packing for polymerase recognition. J. Am. Chem. Soc. 128(19): 6369-75.
2210. May BCH, Witkop J, Sherrill J, Anderson MO, Madrid PB, Zorn JA, Prusiner SB,
Cohen FE, Guy RK. (2006) Structure-activity relationship study of 9-aminoacridine
compounds in scrapie-infected neuroblastoma cells. Bioorg. Med. Chem. Lett. 16(18):
4913-6.
2211. McAllister LA, Hixon MS, Kennedy JP, Dickerson TJ, Janda KD. (2006)
Superactivation of the botulinum neurotoxin serotype a light chain metalloprotease: A
new wrinkle in botulinum neurotoxin. J. Am. Chem. Soc. 128(13): 4176-7.
2212. McClurg P, Pletcher MT, Wiltshire T, Su AI. (2006) Comparative analysis of
haplotype association mapping algorithms. BMC Bioinformatics. 7: 15.
2213. McDunn JE, Chung TP, Laramie JM, Townsend RR, Cobb JP. (2006) Physiologic
genomics. Surgery. 139(2): 133-9.
2214. McDunn JE, Turnbull IR, Polpitiya AD, Tong A, MacMillan SK, Osborne DF,
Hotchkiss RS, Colonna M, Cobb JP. (2006) Splenic cd4+ t cells have a distinct
transcriptional response six hours after the onset of sepsis. J. Am. Coll. Surg. 203(3):
365-75.

2215. McGinness KE, Baker TA, Sauer RT. (2006) Engineering controllable protein
degradation. Mol. Cell. 22(5): 701-7.
2216. McGuckin C, Forraz N, Baradez MO, Basford C, Dickinson AM, Navran S,
Hartgerink JD. (2006) Embryonic-like stem cells from umbilical cord blood and potential
for neural modeling. Acta Neurobiol. Exp. 66(4): 321-9.
2217. McKenzie P, Kiang S, Tom J, Rubin AE, Futran M. (2006) Can pharmaceutical
process development become high tech? AlChE J. 52(12): 3990-4.
2218. McKinney MK, Cravatt BF. (2006) Structure-based design of a faah variant that
discriminates between the n-acyl ethanolamine and taurine families of signaling lipids.
Biochemistry. 45(30): 9016-22.
2219. Medintz IL, Clapp AR, Brunel FM, Tiefenbrunn T, Uyeda HT, Chang EL,
Deschamps JR, Dawson PE, Mattoussi H. (2006) Proteolytic activity monitored by
fluorescence resonance energy transfer through quantum-dot-peptide conjugates. Nat.
Mater. 5(7): 581-9.
2220. Meier JL, Mercer AC, Rivera H, Burkart MD. (2006) Synthesis and evaluation of
bioorthogonal pantetheine analogues for in vivo protein modification. J. Am. Chem. Soc.
128(37): 12174-84.
2221. Melnick JS, Janes J, Kim S, Chang JY, Sipes DG, Gunderson D, Jarnes L,
Matzen JT, Garcia ME, Hood TL, Beigi R, Xia G, Harig RA, Asatryan H, Yan SF, Zhou
YY, Gu XJ, Saadat A, Zhou V, King FJ, Shaw CM, Su AI, Downs R, Gray NS, Schultz
PG, Warmuth M, Caldwell JS. (2006) An efficient rapid system for profiling the cellular
activities of molecular libraries. Proc. Natl. Acad. Sci. U. S. A. 103(9): 3153-8.
2222. Mercer AC, Burkart MD. (2006) Chemical expansion of cofactor activity. Nat.
Chem. Biol. 2(1): 8-10.
2223. Metanis N, Keinan E, Dawson PE. (2006) Synthetic seleno-glutaredoxin 3
analogues are highly reducing oxidoreductases with enhanced catalytic efficiency. J.
Am. Chem. Soc. 128(51): 16684-91.
2224. Milner JM, Kevorkian L, Young DA, Jones D, Wait R, Donell ST, Barksby E,
Patterson AM, Middleton J, Cravatt BF, Clark IM, Rowan AD, Cawston TE. (2006)
Fibroblast activation protein alpha is expressed by chondrocytes following a proinflammatory
stimulus and is elevated in osteoarthritis. Arthritis Res. Ther. 8(1): 8.
2225. Mosley SL, Bakke BA, Sadler JM, Sunkara NK, Dorgan KM, Zhou ZS, Seley-
Radtke KL. (2006) Carbocyclic pyrimidine nucleosides as inhibitors of sadenosylhomocysteine
hydrolase. Bioorg. Med. Chem. 14(23): 7967-71.
2226. Moss JA, Stokols S, Hixon MS, Ashley FT, Chang JY, Janda KD. (2006) Solidphase
synthesis and kinetic characterization of fluorogenic enzyme-degradable
hydrogel cross-linkers. Biomacromolecules. 7(4): 1011-6.
2227. Moulin E, Barluenga S, Totzke F, Winssinger N. (2006) Diversity-oriented
synthesis of pochonins and biological evaluation against a panel of kinases. Chem.-Eur.
J. 12(34): 8819-34.
2228. Mulder AM, Cravatt BF. (2006) Endocannabinoid metabolism in the absence of
fatty acid amide hydrolase (faah): Discovery of phosphorylcholine derivatives of n-acyl
ethanolamines. Biochemistry. 45(38): 11267-77.
2229. Mulgrew K, Kinneer K, Yao XT, Ward BK, Damschroder MM, Walsh B, Mao SY,

Gao C, Kiener PA, Coats S, Kinch MS, Tice DA. (2006) Direct targeting of
alpha(v)beta(3) integrin on tumor cells with a monoclonal antibody, abegrin (tm). Mol.
Cancer Ther. 5(12): 3122-9.
2230. Nanda KK, Nolt MB, Cato MJ, Kane SA, Kiss L, Spencer RH, Wang JX, Lynch
JJ, Regan CP, Stump GL, Li B, White R, Yeh S, Bogusky MJ, Bilodeau MT, Dinsmore
CJ, Lindsley CW, Hartman GD, Wolkenberg SE, Trotter BW. (2006) Potent antagonists
of the kv1.5 potassium channel: Synthesis and evaluation of analogous n,n-diisopropyl-
2-(pyridine-3-yl)acetamides. Bioorg. Med. Chem. Lett. 16(22): 5897-901.
2231. Nangle LA, Motta CM, Schimmel P. (2006) Global effects of mistranslation from
an editing defect in mammalian cells. Chem. Biol. 13(10): 1091-100.
2232. Nash AD, Baca M, Wright C, Scotney PD. (2006) The biology of vascular
endothelial growth factor-b (vegf-b). Pulm. Pharmacol. Ther. 19(1): 61-9.
2233. Nicolaou KC, Brenzovich WE, Bulger PG, Francis TM. (2006) Synthesis of isoepoxy-amphidinolide
n and des-epoxy-caribenolide i structures. Initial forays. Org.
Biomol. Chem. 4(11): 2119-57.
2234. Nicolaou KC, Bulger PG, Brenzovich WE. (2006) Synthesis of iso-epoxyamphidinolide
n and des-epoxy-caribenolide i structures. Revised strategy and final
stages. Org. Biomol. Chem. 4(11): 2158-83.
2235. Nicolaou KC, Chen DYK, Li YW, Uesaka N, Petrovic G, Koftis TV, Bernal F,
Frederick MO, Govindasamy M, Ling TT, Pihko PM, Tang WJ, Vyskocil S. (2006) Total
synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of
originally proposed structures and indication of their non-identity to the natural product.
J. Am. Chem. Soc. 128(7): 2258-67.
2236. Nicolaou KC, Denton RM, Lenzen A, Edmonds DJ, Li A, Milburn RR, Harrison
ST. (2006) Stereocontrolled synthesis of model core systems of lomaiviticins a and b.
Angew. Chem.-Int. Edit. 45(13): 2076-81.
2237. Nicolaou KC, Frederick MO, Loizidou EZ, Petrovic G, Cole KP, Koftis TV,
Yamada YMA. (2006) Second-generation total synthesis of azaspiracids-1,-2, and-3.
Chem.-Asian J. 1(1-2): 245-63.
2238. Nicolaou KC, Frederick MO, Petrovic G, Cole KP, Loizidou EZ. (2006) Total
synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3.
Angew. Chem.-Int. Edit. 45(16): 2609-15.
2239. Nicolaou KC, Harrison ST. (2006) Total synthesis of abyssomicin c and atropabyssomicin
c. Angew. Chem.-Int. Edit. 45(20): 3256-60.
2240. Nicolaou KC, Koftis TV, Vyskocil S, Petrovic G, Tang WJ, Frederick MO, Chen
DYK, Li YW, Ling TT, Yamada YMA. (2006) Total synthesis and structural elucidation of
azaspiracid-1. Final assignment and total synthesis of the correct structure of
azaspiracid-1. J. Am. Chem. Soc. 128(9): 2859-72.
2241. Nicolaou KC, Pihko PM, Bernal F, Frederick MO, Qian WY, Uesaka N, Diedrichs
N, Hinrichs J, Koftis TV, Loizidou E, Petrovic G, Rodriquez M, Sarlah D, Zou N. (2006)
Total synthesis and structural elucidation of azaspiracid-1. Construction of key building
blocks for originally proposed structure. J. Am. Chem. Soc. 128(7): 2244-57.
2242. Nicolaou KC, Pratt BA, Arseniyadis S, Wartmann M, O'Brate A, Giannakakou P.
(2006) Molecular design and chemical synthesis of a highly potent epothilone.

ChemMedChem. 1(1): 41-+.
2243. Nicolaou KC, Xu H. (2006) Total synthesis of floresolide b and delta(6,7)-zfloresolide
b. Chem. Commun. (6): 600-2.
2244. Niculescu AB. (2006) Polypharmacy in oligopopulations: What psychiatric
genetics can teach biological psychiatry. Psychiatr. Genet. 16(6): 241-4.
2245. Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ,
Caligiuri MP, Lohr JB. (2006) Phenochipping of psychotic disorders: A novel approach
for deconstructing and quantitating psychiatric phenotypes. Am. J. Med. Genet. B.
141B(6): 653-62.
2246. Nolt MB, Smiley MA, Varga SL, McClain RT, Wolkenberg SE, Lindsley CW.
(2006) Convenient preparation of substituted 5-aminooxazoles via a microwaveassisted
cornforth rearrangement. Tetrahedron. 62(19): 4698-704.
2247. Nomura DK, Durkin KA, Chiang KP, Quistad GB, Cravatt BF, Casida JE. (2006)
Serine hydrolase kiaa1363: Toxicological and structural features with emphasis on
organophosphate interactions. Chem. Res. Toxicol. 19(9): 1142-50.
2248. Northrop BH, O'Malley DP, Zografos AL, Baran PS, Houk KN. (2006) Mechanism
of the vinylcyclobutane rearrangement of sceptrin to ageliferin and nagelamide e.
Angew. Chem.-Int. Edit. 45(25): 4126-30.
2249. Ohkubo YZ, Thorpe IF. (2006) Evaluating the conformational entropy of
macromolecules using an energy decomposition approach. J. Chem. Phys. 124(2): 6.
2250. Olia AS, Al-Bassam J, Winn-Stapley DA, Joss L, Casjens SR, Cingolani G.
(2006) Binding-induced stabilization and assembly of the phage p22 tail accessory
factor gp4. J. Mol. Biol. 363(2): 558-76.
2251. Orjalo AV, Arnaoutov A, Shen ZX, Boyarchuk Y, Zeitlin SG, Fontoura B, Briggs S,
Dasso M, Forbes DJ. (2006) The nup107-160 nucleoporin complex is required for
correct bipolar spindle assembly. Mol. Biol. Cell. 17(9): 3806-18.
2252. Pant K, Crane BR. (2006) Nitrosyl-heme structures of bacillus subtilis nitric oxide
synthase have implications for understanding substrate oxidation. Biochemistry. 45(8):
2537-44.
2253. Paramonov SE, Jun HW, Hartgerink JD. (2006) Modulation of peptide-amphiphile
nanofibers via phospholipid inclusions. Biomacromolecules. 7(1): 24-6.
2254. Paramonov SE, Jun HW, Hartgerink JD. (2006) Self-assembly of peptideamphiphile
nanofibers: The roles of hydrogen bonding and amphiphilic packing. J. Am.
Chem. Soc. 128(22): 7291-8.
2255. Park SY, Borbat PP, Gonzalez-Bonet G, Bhatnagar J, Pollard AM, Freed JH,
Bilwes AM, Crane BR. (2006) Reconstruction of the chemotaxis receptor-kinase
assembly. Nat. Struct. Mol. Biol. 13(5): 400-7.
2256. Park SY, Lowder B, Bilwes AM, Blair DF, Crane BR. (2006) Structure of flim
provides insight into assembly of the switch complex in the bacterial flagella motor.
Proc. Natl. Acad. Sci. U. S. A. 103(32): 11886-91.
2257. Patapoutian A, Macpherson L. (2006) Channeling pain. Nat. Med. 12(5): 506-7.
2258. Pender MJ, Sowards LA, Hartgerink JD, Stone MO, Naik RR. (2006) Peptidemediated
formation of single-wall carbon nanotube composites. Nano Lett. 6(1): 40-4.
2259. Pennaneach V, Putnam CD, Kolodner RD. (2006) Chromosome healing by de

novo telomere addition in saccharomyces cerevisiae. Mol. Microbiol. 59(5): 1357-68.
2260. Placzek WJ, Almeida MA, Wuthrich K. (2006) Nmr assignment of a human
cancer-related nucleoside triphosphatase. J. Biomol. NMR. 36: 59-.
2261. Plaster B, Semenov AY, Aghalaryan A, Crouse E, MacLachlan G, Tajima S,
Tireman W, Ahmidouch A, Anderson BD, Arenhovel H, Asaturyan R, Baker OK, Baldwin
AR, Barkhuff D, Breuer H, Carlini R, Christy E, Churchwell S, Cole L, Danagoulian S,
Day D, Eden T, Elaasar M, Ent R, Farkhondeh M, Fenker H, Finn JM, Gan L, Gasparian
A, Garrow K, Gueye P, Howell CR, Hu B, Jones MK, Kelly JJ, Keppel C, Khandaker M,
Kim WY, Kowalski S, Lung A, Mack D, Madey R, Manley DM, Markowitz P, Mitchell J,
Mkrtchyan H, Opper AK, Perdrisat C, Punjabi V, Raue B, Reichelt T, Reinhold J, Roche
J, Sato Y, Savvinov N, Semenova IA, Seo W, Simicevic N, Smith G, Stepanyan S,
Tadevosyan V, Tang L, Taylor S, Ulmer PE, Vulcan W, Watson JW, Wells S,
Wesselmann F, Wood S, Yan C, Yang S, Yuan L, Zhang WM, Zhu H, Zhu X, Jefferson
Lab EC. (2006) Measurements of the neutron electric to magnetic form factor ratio
g(en)/g(mn) via the h-2((e)over-right-arrow,e' (n)over-right-arrow)h-1 reaction to
q(2)=1.45 (gev/c)(2). Phys. Rev. C. 73(2): 36.
2262. Powers ET, Deechongkit S, Kelly JW. (2006) Backbone-backbone h-bonds make
context-dependent contributions to protein folding kinetics and thermodynamics:
Lessons from amide-to-ester mutations. Adv. Protein Chem. 72: 39-78.
2263. Pulichino AM, Rowland S, Wu T, Clark P, Xu DG, Mathieu MC, Riendeau D,
Audoly LP. (2006) Prostacyclin antagonism reduces pain and inflammation in rodent
models of hyperalgesia and chronic arthritis. J. Pharmacol. Exp. Ther. 319(3): 1043-50.
2264. Purse BW, Rebek J. (2006) Self-fulfilling cavitands: Packing alkyl chains into
small spaces. Proc. Natl. Acad. Sci. U. S. A. 103(8): 2530-4.
2265. Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, MacLeod IX,
Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M.
(2006) Trb3 links the e3 ubiquitin ligase cop1 to lipid metabolism. Science. 312(5781):
1763-6.
2266. Rao PK, Kumar RM, Farkhondeh M, Baskerville S, Lodish HF. (2006) Myogenic
factors that regulate expression of muscle-specific, micrornas. Proc. Natl. Acad. Sci. U.
S. A. 103(23): 8721-6.
2267. Reyes CL, Ward A, Yu J, Chang G. (2006) The structures of msba: Insight into
abc transporter-mediated multidrug efflux. FEBS Lett. 580(4): 1042-8.
2268. Ritter MR, Banin E, Moreno SK, Aguilar E, Dorrell MI, Friedlander M. (2006)
Myeloid progenitors differentiate into microglia and promote vascular repair in a model
of ischemic retinopathy. J. Clin. Invest. 116(12): 3266-76.
2269. Rogers CJ, Dickerson TJ, Janda KD. (2006) Kinetic isotope and thermodynamic
analysis of the nornicotine-catalyzed aqueous aldol reaction. Tetrahedron. 62(2-3): 352-
6.
2270. Rogers CJ, Eubanks LM, Dickerson TJ, Janda KD. (2006) Unexpected
acetylcholinesterase activity of cocaine esterases. J. Am. Chem. Soc. 128(48): 15364-5.
2271. Rowbottom MW, Vickers TD, Dyck B, Grey J, Tamiya J, Zhang MZ, Kiankarimi
M, Wu DP, Dwight W, Wade WS, Schwarz D, Heise CE, Madan A, Fisher A, Petroski R,
Goodfellow VS. (2006) Synthesis and structure-activity relationships of retro bis-

aminopyrrolidine urea (rapu) derived small-molecule antagonists of the melaninconcentrating
hormone receptor-1 (mch-r1). Part 1. Bioorg. Med. Chem. Lett. 16(17):
4450-7.
2272. Rubin AE, Tummala S, Both DA, Wang CC, Delaney EJ. (2006) Emerging
technologies supporting chemical process r&d and their increasing impact on
productivity in the pharmaceutical industry. Chem. Rev. 106(7): 2794-810.
2273. Rus A, Baxter I, Muthukumar B, Gustin J, Lahner B, Yakubova E, Salt DE. (2006)
Natural variants of athkt1 enhance na+ accumulation in two wild populations of
arabidopsis. PLoS Genet. 2(12): 1964-73.
2274. Safo PK, Cravatt BF, Regehr WG. (2006) Retrograde endocannabinoid signaling
in the cerebellar cortex. Cerebellum. 5(2): 134-45.
2275. Sagan SM, Rouleau Y, Leggiadro C, Supekova L, Schultz PG, Su AI, Pezacki JP.
(2006) The influence of cholesterol and lipid metabolism on host cell structure and
hepatitis c virus replication. Biochem. Cell Biol. 84(1): 67-79.
2276. Saghatelian A, McKinney MK, Bandell M, Patapoutian A, Cravatt BF. (2006) A
faah-regulated class of n-acyl taurines that activates trp ion channels. Biochemistry.
45(30): 9007-15.
2277. Sagle LB, Zimmermann J, Dawson PE, Romesberg FE. (2006) Direct and high
resolution characterization of cytochrome c equilibrium folding. J. Am. Chem. Soc.
128(44): 14232-3.
2278. Sagle LB, Zimmermann J, Matsuda S, Dawson PE, Romesberg FE. (2006)
Redox-coupled dynamics and folding in cytochrome c. J. Am. Chem. Soc. 128(24):
7909-15.
2279. Sanchez L, Sierra M, Martin N, Myles AJ, Dale TJ, Rebek J, Seitz W, Guldi DM.
(2006) Exceptionally strong electronic communication through hydrogen bonds in
porphyrin-c-60 pairs. Angew. Chem.-Int. Edit. 45(28): 4637-41.
2280. Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP,
Wei SH, Parker I, Jo EJ, Cheng WC, Cahalan MD, Wong CH, Rosen H. (2006)
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral
s1p(1) antagonist in vivo. Nat. Chem. Biol. 2(8): 434-41.
2281. Saphire ACS, Gallay PA, Bark SJ. (2006) Proteomic analysis of human
immunodeficency virus using liquid chromatography/tandem mass spectrometry
effectively distinguishes specific incorporated host proteins. J. Proteome Res. 5(3): 530-
8.
2282. Saraf-Levy T, Santoro SW, Volpin H, Kushnirsky T, Eyal Y, Schultz PG, Gidoni D,
Carmi N. (2006) Site-specific recombination of asymmetric lox sites mediated by a
heterotetrameric cre recombinase complex. Bioorg. Med. Chem. 14(9): 3081-9.
2283. Sastry M, Brown C, Wagner G, Clark TD. (2006) Cyclic peptide helices: A hybrid
beta-hairpin/beta-helical supersecondary structure. J. Am. Chem. Soc. 128(33): 10650-
1.
2284. Sawa M, Hsu TL, Itoh T, Sugiyama M, Hanson SR, Vogt PK, Wong CH. (2006)
Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo. Proc.
Natl. Acad. Sci. U. S. A. 103(33): 12371-6.
2285. Sawkar AR, D'Haeze W, Kelly JW. (2006) Therapeutic strategies to ameliorate

lysosomal storage disorders - a focus on gaucher disease. Cell. Mol. Life Sci. 63(10):
1179-92.
2286. Sawkar AR, Schmitz M, Zimmer KP, Reczek D, Edmunds T, Balch WE, Kelly JW.
(2006) Chemical chaperones and permissive temperatures atter the cellular locatization
of gaucher disease associated glucocerebrosidase variants. ACS Chem. Biol. 1(4): 235-
51.
2287. Schmidt KH, Pennaneach V, Putnam CD, Kolodner RD. (2006) Analysis of grosschromosomal
rearrangements in saccharomyces cerevisiae. Methods Enzymol. 409:
462-76.
2288. Schnermann MJ, Romero FA, Hwang I, Nakamaru-Ogiso E, Yagi T, Boger DL.
(2006) Total synthesis of piericidin a1 and b1 and key analogues. J. Am. Chem. Soc.
128(36): 11799-807.
2289. Schultz KC, Supekova L, Ryu YH, Xie JM, Perera R, Schultz PG. (2006) A
genetically encoded infrared probe. J. Am. Chem. Soc. 128(43): 13984-5.
2290. Schultz KR, Miklos DB, Fowler D, Cooke K, Shizuru J, Zorn E, Holler E, Ferrara
Y, Shulman H, Lee SY, Martin P, Filipovich AH, Flowers MED, Weisdorf D, Couriel D,
Lachenbruch PA, Mittleman B, Vogelsang GB, Pavletic SZ. (2006) Toward biomarkers
for chronic graft-versus-host disease: National institutes of health consensus
development project on criteria for clinical trials in chronic graft-versus-host disease: Iii.
Biomarker working group report. Biol. Blood Marrow Transplant. 12(2): 126-37.
2291. Seburn KL, Nangle LA, Cox GA, Schimmel P, Burgess RW. (2006) An active
dominant mutation of glycyl-trna synthetase causes neuropathy in a charcot-marie-tooth
2d mouse model. Neuron. 51(6): 715-26.
2292. Seike H, Ghosh I, Kishi Y. (2006) Attempts to assemble a universal nmr
database without synthesis of nmr database compounds. Org. Lett. 8(17): 3861-4.
2293. Seike H, Ghosh I, Kishi Y. (2006) Stereochemistry of sagittamide a: Prediction
and confirmation. Org. Lett. 8(17): 3865-8.
2294. Sekijima Y, Dendle MT, Wiseman RL, White JT, D'Haeze W, Kelly JW. (2006)
R104h may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but
not by the kinetic mechanism characterizing t119 interallelic trans-suppression.
Amyloid-J. Protein Fold. Disord. 13(2): 57-66.
2295. Sevecka M, MacBeath G. (2006) State-based discovery: A multidimensional
screen for small-molecule modulators of egf signaling. Nat. Methods. 3(10): 825-31.
2296. Sherman DH, Li SY, Yermalitskaya LV, Kim YC, Smith JA, Waterman MR,
Podust LM. (2006) The structural basis for substrate anchoring, active site selectivity,
and product formation by p450 pikc from streptomyces venezuelae. J. Biol. Chem.
281(36): 26289-97.
2297. Shibuya T, Tange TO, Stroupe ME, Moore MJ. (2006) Mutational analysis of
human eif4aiii identifies regions necessary for exon junction complex formation and
nonsense-mediated mrna decay. RNA-Publ. RNA Soc. 12(3): 360-74.
2298. Shigenaga A, Moss JA, Ashley FT, Kaufmann GF, Janda KD. (2006) Solid-phase
synthesis and cyclative cleavage of quorum sensing depsipeptide analogues by
acylphenyldiazene activation. Synlett. (4): 551-4.
2299. Shimogawa MM, Graczyk B, Gardner MK, Francis SE, White EA, Ess M, Molk

JN, Ruse C, Niessen S, Yates JR, Muller EGD, Bloom K, Odde DJ, Davis TN. (2006)
Mps1 phosphorylation of dam1 couples kinetochores to microtubule plus ends at
metaphase. Curr. Biol. 16(15): 1489-501.
2300. Shipe WD, Yang F, Zhao ZJ, Wolkenberg SE, Nolt MB, Lindsley CW. (2006)
Convenient and general microwave-assisted protocols for the expedient synthesis of
heterocycles. Heterocycles. 70: 655-+.
2301. Sieber SA, Cravatt BF. (2006) Analytical platforms for activity-based protein
profiling - exploiting the versatility of chemistry for functional proteomics. Chem.
Commun. (22): 2311-9.
2302. Sieber SA, Niessen S, Hoover HS, Cravatt BF. (2006) Proteomic profiling of
metalloprotease activities with cocktails of active-site probes. Nat. Chem. Biol. 2(5):
274-81.
2303. Siegmund SV, Seki E, Osawa Y, Uchinami H, Cravatt BF, Schwabe RF. (2006)
Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. J.
Biol. Chem. 281(15): 10431-8.
2304. Simon GM, Cravatt BF. (2006) Endocannabinoid biosynthesis proceeding
through glycerophospho-n-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in
this pathway. J. Biol. Chem. 281(36): 26465-72.
2305. Smith APL, Henze M, Lee JA, Osborn KG, Keck JM, Tedesco D, Bortner DM,
Rosenberg MP, Reed SI. (2006) Deregulated cyclin e promotes p53 loss of
heterozygosity and tumorigenesis in the mouse mammary gland. Oncogene. 25(55):
7245-59.
2306. Snyder SA. (2006) From abyssomicin to zaragozic acid: Chemical synthesis and
drug innovation. Angew. Chem.-Int. Edit. 45(29): 4714-.
2307. Snyder SA, Corey EJ. (2006) Concise total syntheses of palominol,
dolabellatrienone, beta-araneosene, and isoedunol via an enantioselective diels-alder
macrobicyclization. J. Am. Chem. Soc. 128(3): 740-2.
2308. Snyder SA, Corey EJ. (2006) Regioselective aldol condensations of a
cholestanone-derived dialdehyde: New twists on a classic reaction. Tetrahedron Lett.
47(13): 2083-6.
2309. Song E, Gao SJ, Tian R, Ma S, Huang HM, Guo JY, Li YN, Zhang L, Gao YH.
(2006) A high efficiency strategy for binding property characterization of peptide-binding
domains. Mol. Cell. Proteomics. 5(8): 1368-81.
2310. Stagg SM, Gurkan C, Fowler DM, LaPointe P, Foss TR, Potter CS, Carragher B,
Balch WE. (2006) Structure of the sec13/31 copii coat cage. Nature. 439(7073): 234-8.
2311. Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA. (2006) Crystal structure
of the il-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor. Proc. Natl.
Acad. Sci. U. S. A. 103(8): 2788-93.
2312. Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G. (2006) Uncovering
quantitative protein interaction networks for mouse pdz domains using protein
microarrays. J. Am. Chem. Soc. 128(17): 5913-22.
2313. Stroupe ME, Tange TO, Thomas DR, Moore MJ, Grigorieff N. (2006) The threedimensional
architecture of the ejc core. J. Mol. Biol. 360(4): 743-9.
2314. Sud D, Mehta G, Mehta K, Linderman J, Takayama S, Mycek MA. (2006) Optical

imaging in microfluidic bioreactors enables oxygen monitoring for continuous cell
culture. J. Biomed. Opt. 11(5): 3.
2315. Sudhamsu J, Crane BR. (2006) Structure and reactivity of a thermostable
prokaryotic nitric-oxide synthase that forms a long-lived oxy-heme complex. J. Biol.
Chem. 281(14): 9623-32.
2316. Suh RS, Zhu XY, Phadke N, Ohl DA, Takayama S, Smith GD. (2006) Ivf within
microfluidic channels requires lower total numbers and lower concentrations of sperm.
Hum. Reprod. 21(2): 477-83.
2317. Takagi Y, Calero G, Komori H, Brown JA, Ehrensberger AH, Hudmon A, Asturias
F, Kornberg RD. (2006) Head module control of mediator interactions. Mol. Cell. 23(3):
355-64.
2318. Takeuchi C, Galve R, Nieva J, Witter DP, Wentworth AD, Troseth RP, Lerner RA,
Wentworth P. (2006) Proatherogenic effects of the cholesterol ozonolysis products,
atheronal-a and atheronal-b. Biochemistry. 45(23): 7162-70.
2319. Tanaka KA, Fernandez JA, Marzec UM, Kelly AB, Mohri M, Griffin JH, Hanson
SR, Gruber A. (2006) Soluble thrombomodulin is antithrombotic in the presence of
neutralising antibodies to protein c and reduces circulating activated protein c levels in
primates. Br. J. Haematol. 132(2): 197-203.
2320. Tarby CM, Kaltenbach RF, Huynh T, Pudzianowski A, Shen H, Ortega-Nanos M,
Sheriff S, Newitt JA, McDonnell PA, Burford N, Fairchild CR, Vaccaro W, Chen Z,
Borzilleri RM, Naglich J, Lombardo LJ, Gottardis M, Trainor GL, Roussell DL. (2006)
Inhibitors of human mitotic kinesin eg5: Characterization of the 4-phenyltetrahydrolsoquinoline
lead series. Bioorg. Med. Chem. Lett. 16(8): 2095-100.
2321. Thayer DA, Wong CH. (2006) Vancomycin analogues containing
monosaccharides exhibit improved antibiotic activity: A combined one-pot enzymatic
glycosylation and chemical diversification strategy. Chem.-Asian J. 1(3): 445-52.
2322. Thompson MJ, Sievers SA, Karanicolas J, Ivanova MI, Baker D, Eisenberg D.
(2006) The 3d profile method for identifying fibril-forming segments of proteins. Proc.
Natl. Acad. Sci. U. S. A. 103(11): 4074-8.
2323. Tian T, Debler EW, Millar DP, Deniz AA, Wilson IA, Schultz PG. (2006) The
effects of antibodies on stilbene excited-state energetics. Angew. Chem.-Int. Edit.
45(46): 7763-5.
2324. Tian Z, Liu YM, Chen SB, Yang JS, Xiao PG, Wang L, Wu E. (2006) Cytotoxicity
of two triterpenoids from nigella glandulifera. Molecules. 11(9): 693-9.
2325. Tichenor MS, Trzupek JD, Kastrinsky DB, Shiga F, Hwang I, Boger DL. (2006)
Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin sa:
Evaluation of yatakemycin key partial structures and its unnatural enantiomer. J. Am.
Chem. Soc. 128(49): 15683-96.
2326. Trzupek JD, Gottesfeld JM, Boger DL. (2006) Alkylation of duplex DNA in
nucleosome core particles by duocarmycin sa and yatakemycin. Nat. Chem. Biol. 2(2):
79-82.
2327. Tully DC, Liu H, Alper PB, Chatterjee AK, Epple R, Roberts MJ, Williams JA,
Nguyen KT, Woodmansee DH, Tumanut C, Li J, Spraggon G, Chang J, Tuntland T,
Harris JL, Karanewsky DS. (2006) Synthesis and evaluation of arylaminoethyl amides

as noncovalent inhibitors of cathepsin s. Part 3: Heterocyclic p3. Bioorg. Med. Chem.
Lett. 16(7): 1975-80.
2328. Tully DC, Liu H, Chatterjee AK, Alper PB, Epple R, Williams JA, Roberts MJ,
Woodmansee DH, Masick BT, Tumanut C, Li J, Spraggon G, Hornsby M, Chang J,
Tuntland T, Hollenbeck T, Gordon P, Harris JL, Karanewsky DS. (2006) Synthesis and
sar of arylaminoethyl amides as noncovalent inhibitors of cathepsin s: P3 cyclic ethers.
Bioorg. Med. Chem. Lett. 16(19): 5112-7.
2329. Tully DC, Liu H, Chatterjee AK, Alper PB, Williams JA, Roberts MJ, Mutnick D,
Woodmansee DH, Hollenbeck T, Gordon P, Chang J, Tuntland T, Tumanut C, Li J,
Harris JL, Karanewsky DS. (2006) Arylaminoethyl carbamates as a novel series of
potent and selective cathepsin s inhibitors. Bioorg. Med. Chem. Lett. 16(19): 5107-11.
2330. Turner JM, Graziano J, Spraggon G, Schultz PG. (2006) Structural plasticity of an
aminoacyl-trna synthetase active site. Proc. Natl. Acad. Sci. U. S. A. 103(17): 6483-8.
2331. Ueki M, Galonic DP, Vaillancourt FH, Garneau-Tsodikova S, Yeh E, Vosburg DA,
Schroeder FC, Osada H, Walsh CT. (2006) Enzymatic generation of the antimetabolite
gamma,gamma-dichloroaminobutyrate by nrps and mononuclear iron halogenase action
in a streptomycete. Chem. Biol. 13(11): 1183-91.
2332. Urbina HD, Debaene F, Jost B, Bole-Feysot C, Mason DE, Kuzmic P, Harris JL,
Winssinger N. (2006) Self-assembled small-molecule microarrays for protease
screening and profiling. Chembiochem. 7(11): 1790-7.
2333. Va P, Roush WR. (2006) Total synthesis of amphidinolide e. J. Am. Chem. Soc.
128(50): 15960-1.
2334. Vaillancourt FH, Vosburg DA, Walsh CT. (2006) Dichlorination and bromination
of a threonyl-s-carrier protein by the non-heme fe-ii halogenase syrb2. Chembiochem.
7(5): 748-52.
2335. Vaillancourt FH, Yeh E, Vosburg DA, Garneau-Tsodikova S, Walsh CT. (2006)
Nature's inventory of halogenation catalysts: Oxidative strategies predominate. Chem.
Rev. 106(8): 3364-78.
2336. Varvel SA, Cravatt BF, Engram AE, Lichtman AH. (2006) Fatty acid amide
hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of
anandamide or oleamide in a working memory water maze task. J. Pharmacol. Exp.
Ther. 317(1): 251-7.
2337. Vieth M, Sutherland JJ. (2006) Dependence of molecular properties on proteomic
family for marketed oral drugs. J. Med. Chem. 49(12): 3451-3.
2338. Vilarino N, Nicolaou KC, Frederick MO, Cagide E, Ares IR, Louzao MC, Vieytes
MR, Botana LM. (2006) Cell growth inhibition and actin cytoskeleton disorganization
induced by azaspiracid-1 structure-activity studies. Chem. Res. Toxicol. 19(11): 1459-
66.
2339. Vos TJ, Balani S, Blackburn C, Chau RW, Danca MD, Drabic SV, Farrer CA,
Patane MA, Stroud SG, Yowe DL, Claiborne CF. (2006) Identification and structureactivity
relationships of a new series of melanocortin-4 receptor antagonists. Bioorg.
Med. Chem. Lett. 16(8): 2302-5.
2340. Wang H, Xie H, Guo Y, Zhang H, Takahashi T, Kingsley PJ, Marnett LJ, Das SK,
Cravatt BF, Dey SK. (2006) Fatty acid amide hydrolase deficiency limits early

pregnancy events. J. Clin. Invest. 116(8): 2122-31.
2341. Wang JY, Xie JM, Schultz PG. (2006) A genetically encoded fluorescent amino
acid. J. Am. Chem. Soc. 128(27): 8738-9.
2342. Wang L, Li YZ, Huang HM, Fang WS. (2006) Catalytic enantioselective ring
opening of epoxides. Chin. J. Org. Chem. 26(9): 1208-16.
2343. Wang TY, Chuang TH, Ronni T, Gu S, Du YC, Cai H, Sun HQ, Yin HL, Chen X.
(2006) Flightless i homology negatively modulates the tlr pathway. J. Immunol. 176(3):
1355-62.
2344. Warashina M, Min KH, Kuwabara T, Huynh A, Gage FH, Schultz PG, Ding S.
(2006) A synthetic small molecule that induces neuronal differentiation of adult
hippocampal neural progenitor cells. Angew. Chem.-Int. Edit. 45(4): 591-3.
2345. Watanabe K, Hotta K, Praseuth AP, Koketsu K, Migita A, Boddy CN, Wang CCC,
Oguri H, Oikawa H. (2006) Total biosynthesis of antitumor nonribosomal peptides in
escherichia coli. Nat. Chem. Biol. 2(8): 423-8.
2346. Wei BQQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF. (2006) A second
fatty acid amide hydrolase with variable distribution among placental mammals. J. Biol.
Chem. 281(48): 36569-78.
2347. Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC. (2006)
Structure of a central component of the yeast kinetochore: The spc24p/spc25p globular
domain. Structure. 14(6): 1003-9.
2348. Wei YX, He YL, Zhang DH, Xu L, Meng SH, Liu ZM, Su BL. (2006) Study of mn
incorporation into sapo framework: Synthesis, characterization and catalysis in
chloromethane conversion to light olefins. Microporous Mesoporous Mat. 90(1-3): 188-
97.
2349. Weller HN, Nirschl DS, Petrillo EW, Poss MA, Andres CJ, Cavallaro CL, Echols
MM, Grant-Young KA, Houston JG, Miller AV, Swann RT. (2006) Application of lean
manufacturing concepts to drug discovery: Rapid analogue library synthesis. J. Comb.
Chem. 8(5): 664-9.
2350. Widlund PO, Lyssand JS, Anderson S, Niessen S, Yates JR, Davis TN. (2006)
Phosphorylation of the chromosomal passenger protein bir1 is required for localization
of ndc10 to the spindle during anaphase and full spindle elongation. Mol. Biol. Cell.
17(3): 1065-74.
2351. Wikoff WR, Conway JF, Tang JH, Lee KK, Gan L, Cheng NQ, Duda RL, Hendrix
RW, Steven AC, Johnson JE. (2006) Time-resolved molecular dynamics of
bacteriophage hk97 capsid maturation interpreted by electron cryo-microscopy and xray
crystallography. J. Struct. Biol. 153(3): 300-6.
2352. Wolkenberg SE, Zhao ZJ, Kapitskaya A, Webber AL, Petrukhin K, Tang YS,
Dean DC, Hartman GD, Lindsley CW. (2006) Identification of potent agonists of
photoreceptor-specific nuclear receptor (nr2e3) and preparation of a radioligand. Bioorg.
Med. Chem. Lett. 16(19): 5001-4.
2353. Worthington AS, Burkart MD. (2006) One-pot chemo-enzymatic synthesis of
reporter-modified proteins. Org. Biomol. Chem. 4(1): 44-6.
2354. Worthington AS, Rivera H, Torpey JW, Alexander MD, Burkart MD. (2006)
Mechanism-based protein cross-linking probes to investigate carrier protein-mediated

iosynthesis. ACS Chem. Biol. 1(11): 687-91.
2355. Wu D, Zajonc DM, Fujio M, Sullivan BA, Kinjo Y, Kronenberg M, Wilson IA, Wong
CH. (2006) Design of natural killer t cell activators: Structure and function of a microbial
glycosphingolipid bound to mouse cd1d. Proc. Natl. Acad. Sci. U. S. A. 103(11): 3972-7.
2356. Wu JM, Chung YK, Belford KJ, Smith GD, Takayama S, Lahann J. (2006) A
surface-modified sperm sorting device with long-term stability. Biomed. Microdevices.
8(2): 99-107.
2357. Wu P, Hilgraf R, Fokin VV. (2006) Osmium-catalyzed olefin dihydroxylation and
aminohydroxylation in the second catalytic cycle. Adv. Synth. Catal. 348(9): 1079-85.
2358. Wunberg T, Hendrix M, Hillisch A, Lobell M, Meier H, Schmeck C, Wild H, Hinzen
B. (2006) Improving the hit-to-lead process: Data-driven assessment of drug-like and
lead-like screening hits. Drug Discov. Today. 11(3-4): 175-80.
2359. Xia CH, Cheung D, DeRosa AM, Chang B, Lo WK, White TW, Gong XH. (2006)
Knock-in of alpha 3 connexin prevents severe cataracts caused by an alpha 8 point
mutation. J. Cell Sci. 119(10): 2138-44.
2360. Xia CH, Liu H, Cheung D, Cheng C, Wang E, Du X, Beutler B, Lo WK, Gong XH.
(2006) Diverse gap junctions modulate distinct mechanisms for fiber cell formation
during lens development and cataractogenesis. Development. 133(10): 2033-40.
2361. Xia CH, Liu H, Wang M, Cheung D, Park A, Yang Y, Du X, Chang B, Beutler B,
Gong X. (2006) Characterization of mouse mutants with abnormal rpe cells. Adv. Exp.
Med. Biol. 572: 95-100.
2362. Xia CH, Liu HQ, Chang B, Cheng C, Cheung D, Wang M, Huang QL, Horwitz J,
Gong XH. (2006) Arginine 54 and tyrosine 118 residues of alpha a-crystallin are crucial
for lens formation and transparency. Invest. Ophthalmol. Vis. Sci. 47(7): 3004-10.
2363. Xie JM, Schultz PG. (2006) Innovation: A chemical toolkit for proteins - an
expanded genetic code. Nat. Rev. Mol. Cell Biol. 7(10): 775-82.
2364. Xu Y, Lu H, Kennedy JP, Yan XX, McAllister LA, Yamamoto N, Moss JA, Boldt
GE, Jiang SB, Janda KD. (2006) Evaluation of "Credit card" Libraries for inhibition of
hiv-1 gp41 fusogenic core formation. J. Comb. Chem. 8(4): 531-9.
2365. Xu Y, Shi J, Yamamoto N, Mossa JA, Vogt PK, Janda KD. (2006) A credit-card
library approach for disrupting protein-protein interactions. Bioorg. Med. Chem. 14(8):
2660-73.
2366. Xue XH, Lai KTA, Huang JF, Gu Y, Karlsson L, Fourie A. (2006) Antiinflammatory
activity in vitro and in vivo of the protein farnesyltransferase inhibitor
tipifarnib. J. Pharmacol. Exp. Ther. 317(1): 53-60.
2367. Yachi PP, Ampudia J, Zal T, Gascoigne NRJ. (2006) Altered peptide ligands
induce delayed cd8-t cell receptor interaction - a role for cd8 in distinguishing antigen
quality. Immunity. 25(2): 203-11.
2368. Yadav MK, Leman LJ, Price DJ, Brooks CL, Stout CD, Ghadiri MR. (2006) Coiled
coils at the edge of configurational heterogeneity. Structural analyses of parallel and
antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single
solvent-exposed amino acid substitution. Biochemistry. 45(14): 4463-73.
2369. Yamamoto N, Takayanagi A, Sakakibara T, Dawson PE, Kajihara Y. (2006)
Highly efficient synthesis of sialylglycopeptides overcoming unexpected aspartimide

formation during activation of fmoc-asn(undecadisialyloligosaccharide)-oh. Tetrahedron
Lett. 47(8): 1341-6.
2370. Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S. (2006) Long-term
self-renewal and directed differentiation of human embryonic stem cells in chemically
defined conditions. Proc. Natl. Acad. Sci. U. S. A. 103(18): 6907-12.
2371. Yao Y, Martinez-Yamout MA, Dickerson TJ, Brogan AP, Wright PE, Dyson HJ.
(2006) Structure of the escherichia coli quorum sensing protein sdia: Activation of the
folding switch by acyl homoserine lactones. J. Mol. Biol. 355(2): 262-73.
2372. Yue EW, Wayland B, Douty B, Crawley ML, McLaughlin E, Takvorian A,
Wasserman Z, Bower MJ, Wei M, Li YL, Ala PJ, Gonneville L, Wynn R, Burn TC, Liu
PCC, Combs AP. (2006) Isothiazolidinone heterocycles as inhibitors of protein tyrosine
phosphatases: Synthesis and structure-activity relationships of a peptide scaffold.
Bioorg. Med. Chem. 14(17): 5833-49.
2373. Zambricki E, Zal T, Yachi P, Shigeoka A, Sprent J, Gascoigne N, McKay D.
(2006) In vivo anergized t cells form altered immunological synapses in vitro. Am. J.
Transplant. 6(11): 2572-9.
2374. Zhang LG, Long H, Boldt GE, Janda KD, Schatz GC, Lewis FD. (2006) Alpha-
and beta-stilbenosides as base-pair surrogates in DNA hairpins. Org. Biomol. Chem.
4(2): 314-22.
2375. Zhang Y, Ki Y, Genoud N, Gao JM, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel
JP. (2006) Determinants for dephosphorylation of the rna polymerase ii c-terminal
domain by scp1. Mol. Cell. 24(5): 759-70.
2376. Zhao ZJ, O'Brien JA, Lemaire W, Williams DL, Jacobson MA, Sur C, Pettibone
DJ, Tiller PR, Smith S, Hartman GD, Wolkenberg SE, Lindsley CW. (2006) Synthesis
and sar of glyt1 inhibitors derived from a series of n-((4-(morpholine-4-carbonyl)-1-
(propylsulfonyl)piperidin-4-yl)- methyl)benzamides. Bioorg. Med. Chem. Lett. 16(23):
5968-72.
2377. Zhong BY, Al-Awar RS, Shih C, Grimes JH, Vieth M, Hamdouchi C. (2006) Novel
route to the synthesis of 4-quinolyl isothiocyanates. Tetrahedron Lett. 47(13): 2161-4.
2378. Zhu XY, Dickerson TJ, Rogers CJ, Kaufmann GF, Mee JM, McKenzie KM, Janda
KD, Wilson IA. (2006) Complete reaction cycle of a cocaine catalytic antibody at atomic
resolution. Structure. 14(2): 205-16.
2379. Zimmermann J, Oakman EL, Thorpe IF, Shi XH, Abbyad P, Brooks CL, Boxer
SG, Romesberg FE. (2006) Antibody evolution constrains conformational heterogeneity
by tailoring protein dynamics. Proc. Natl. Acad. Sci. U. S. A. 103(37): 13722-7.
2380. Zorrilla EP, Iwasaki S, Moss JA, Chang J, Otsuji J, Inoue K, Meijler MM, Janda
KD. (2006) Vaccination against weight gain. Proc. Natl. Acad. Sci. U. S. A. 103(35):
13226-31.
2381. Adam GC, Meng JC, Athanasopoulos J, Zhang XP, Chapman KT. (2007) Affinitybased
ranking of ligands for dpp-4 from mixtures. Bioorg. Med. Chem. Lett. 17(9): 2404-
7.
2382. Agiostratidou G, Hulit J, Phillips GR, Hazan RB. (2007) Differential cadherin
expression: Potential markers for epithelial to mesenchymal transformation during tumor
progression. J. Mammary Gland Biol. Neoplasia. 12(2-3): 127-33.

2383. Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund
ET, Nugent RA, Nomanbhoy TK, Alexander JP, Cravatt BF. (2007) Novel mechanistic
class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry.
46(45): 13019-30.
2384. Al-Bassam J, Larsen NA, Hyman AA, Harrison SC. (2007) Crystal structure of a
tog domain: Conserved features of xmap215/dis1-family tog domains and implications
for tubulin binding. Structure. 15(3): 355-62.
2385. Al-Bassam J, Roger B, Halpain S, Milligan RA. (2007) Analysis of the weak
interactions of adp-unc104 and adp-kinesin with microtubules and their inhibition by
map2c. Cell Motil. Cytoskeleton. 64(5): 377-89.
2386. Ambasudhan R, Ding S. (2007) An "Orphan" Finds a home in nsc regulation.
Chem. Biol. 14(9): 974-5.
2387. Anderson JC, Voigt CA, Arkin AP. (2007) Environmental signal integration by a
modular and gate. Mol. Syst. Biol. 3: 8.
2388. Arnold LA, Kosinski A, Estebanez-Perpina E, Fletterick RJ, Guy RK. (2007)
Inhibitors of the interaction of a thyroid hormone receptor and coactivators: Preliminary
structure-activity relationships. J. Med. Chem. 50(22): 5269-80.
2389. Balicki D. (2007) Moving forward in human mammary stem cell biology and
breast cancer prognostication using aldh1. Cell Stem Cell. 1(5): 485-7.
2390. Bandell M, Macpherson LJ, Patapoutian A. (2007) From chills to chilis:
Mechanisms for thermosensation and chemesthesis via thermotrps. Curr. Opin.
Neurobiol. 17(4): 490-7.
2391. Baran PS, Maimone TJ. (2007) Organic chemistry - a tuxedo for iodine atoms.
Nature. 445(7130): 826-7.
2392. Baran PS, Maimone TJ, Richter JM. (2007) Total synthesis of marine natural
products without using protecting groups. Nature. 446(7134): 404-8.
2393. Barglow KT, Cravatt BF. (2007) Activity-based protein profiling for the functional
annotation of enzymes. Nat. Methods. 4(10): 822-7.
2394. Bark SJ, Hook V. (2007) Differential recovery of peptides from sample tubes and
the reproducibility of quantitative proteomic data. J. Proteome Res. 6(11): 4511-6.
2395. Bark SJ, Hook V. (2007) The future of proteomic analysis in biological systems
and molecular medicine. Mol. Biosyst. 3(1): 14-7.
2396. Barrett ES, Dale TJ, Rebek J. (2007) Synthesis and assembly of
monofunctionalized pyrogallolarene capsules monitored by fluorescence resonance
energy transfer. Chem. Commun. (41): 4224-6.
2397. Barrett ES, Dale TJ, Rebek J. (2007) Self-assembly dynamics of a cylindrical
capsule monitored by fluorescence resonance energy transfer. J. Am. Chem. Soc.
129(28): 8818-24.
2398. Barrett ES, Dale TJ, Rebek J. (2007) Assembly and exchange of resorcinarene
capsules monitored by fluorescence resonance energy transfer. J. Am. Chem. Soc.
129(13): 3818-+.
2399. Batkai S, Rajesh M, Mukhopadhyay P, Haska G, Liaudet L, Cravatt BF, Csiszar
A, Ungvari Z, Pacher P. (2007) Decreased age-related cardiac dysfunction, myocardial
nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid

amide hydrolase. Am. J. Physiol.-Heart Circul. Physiol. 293(2): H909-H18.
2400. Baxter I, Ouzzani M, Orcun S, Kennedy B, Jandhyala SS, Salt DE. (2007) Purdue
ionomics information management system. An integrated functional genomics platform.
Plant Physiol. 143(2): 600-11.
2401. Beck ZQ, Burr DA, Sherman DH. (2007) Characterization of the betamethylaspartate-alpha-decarboxylase
(crpg) from the cryptophycin biosynthetic
pathway. Chembiochem. 8(12): 1373-5.
2402. Beohar N, Flaherty JD, Davidson CJ, Vidovich M, Singhal S, Rapp JA, Erdogan
A, Lee DC, Rammohan C, Brodsky A, Wu E, Chundra S, Klaus H, Davidson L, Pieper K,
Virmani R, Bonow RO, Mehta J. (2007) Granulocyte-colony stimulating factor
administration after myocardial infarction in a porcine ischemia-reperfusion model:
Functional and pathological effects of dose timing. Catheter. Cardiovasc. Interv. 69(2):
257-65.
2403. Berlin M, Boyce CW. (2007) Recent advances in the development of histamine h-
3 antagonists. Expert Opin. Ther. Patents. 17(6): 675-87.
2404. Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL. (2007)
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. J. Am.
Chem. Soc. 129(9): 2456-+.
2405. Bhatnagar J, Freed JH, Crane BR. (2007) Rigid body refinement of protein
complexes with long-range distance restraints from pulsed dipolar esr. Methods
Enzymol. 423: 117-+.
2406. Biros SM, Bergman RG, Raymond KN. (2007) The hydrophobic effect drives the
recognition of hydrocarbons by an anionic metal-ligand cluster. J. Am. Chem. Soc.
129(40): 12094-+.
2407. Biros SM, Moisan L, Mann E, Carella A, Zhai D, Reed JC, Rebek J. (2007)
Heterocyclic alpha-helix mimetics for targeting protein-protein interactions. Bioorg. Med.
Chem. Lett. 17(16): 4641-5.
2408. Biros SM, Rebek J. (2007) Structure and binding properties of water-soluble
cavitands and capsules. Chem. Soc. Rev. 36(1): 93-104.
2409. Blankenship JW, Dawson PE. (2007) Threading a peptide through a peptide:
Protein loops, rotaxanes, and knots. Protein Sci. 16(7): 1249-56.
2410. Blankman JL, Simon GM, Cravatt BF. (2007) A comprehensive profile of brain
enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem. Biol.
14(12): 1347-56.
2411. Blednov YA, Cravatt BF, Boehm SL, Walker D, Harris RA. (2007) Role of
endocannabinoids in alcohol consumption and intoxication: Studies of mice lacking fatty
acid amide hydrolase. Neuropsychopharmacology. 32(7): 1570-82.
2412. Boess FG, De Vry J, Erb C, Flessner T, Hendrix M, Luithle J, Methfessel C, Riedl
B, Schnizler K, van der Staay FJ, van Kampen M, Wiese WB, Koenig G. (2007) The
novel alpha 7 nicotinic acetylcholine receptor agonist n-[(3r)-1-azabicyclo[2.2.2]oct-3-yl]-
7-[2-(methoxy)phenyl]-1-benzofuran- 2-carboxamide improves working and recognition
memory in rodents. J. Pharmacol. Exp. Ther. 321(2): 716-25.
2413. Bogyo M, Cravatt BF. (2007) From genes to function: Advances in applications of
chemical and systems biology. Curr. Opin. Chem. Biol. 11(1): 1-3.

2414. Borevitz JO, Hazen SP, Michael TP, Morris GP, Baxter IR, Hu TT, Chen H,
Werner JD, Nordborg M, Salf DE, Kay SA, Chory J, Weigel D, Jones JDG, Ecker JR.
(2007) Genome-wide patterns of single-feature polymorphism in arabidopsis thaliana.
Proc. Natl. Acad. Sci. U. S. A. 104(29): 12057-62.
2415. Bornes S, Prado-Lourenco L, Bastide A, Zanibellato C, Iacovoni JS, Lacazette E,
Prats AC, Touriol C, Prats H. (2007) Translational induction of vegf internal ribosome
entry site elements during the early response to ischemic stress. Circ.Res. 100(3): 305-
8.
2416. Bowley DR, Labrijn AF, Zwick MB, Burton DR. (2007) Antigen selection from an
hiv-1 immune antibody library displayed on yeast yields many novel antibodies
compared to selection from the same library displayed on phage. Protein Eng. Des. Sel.
20(2): 81-90.
2417. Bratton LD, Auerbach B, Choi C, Dillon L, Hanselman JC, Larsen SD, Lu G,
Olsen K, Pfefferkorn JA, Robertson A, Sekerke C, Trivedi BK, Unangst PC. (2007)
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of hmg-coa
reductase. Bioorg. Med. Chem. 15(16): 5576-89.
2418. Brnardic EJ, Garbaccio RM, Fraley ME, Tasber ES, Steen JT, Arrington KL,
Dudkin VY, Hartman GD, Stirdivant SM, Drakas BA, Rickert K, Walsh ES, Hamilton K,
Buser CA, Hardwick J, Tao WK, Beek SC, Mao XZ, Lobell RB, Sepp-Lorenzino L, Yan
YW, Ikuta M, Munshi SK, Kuo LC, Kreatsoulas C. (2007) Optimization of a
pyrazoloquinolinone class of chk1 kinase inhibitors. Bioorg. Med. Chem. Lett. 17(21):
5989-94.
2419. Brogan AP, Dickerson TJ, Janda KD. (2007) Noirnicotine-organocatalyzed
aqueous reduction of alpha,beta-unsaturated aldehydes. Chem. Commun. (46): 4952-4.
2420. Brogan AP, Eubanks LM, Koob GF, Dickerson TJ, Janda KD. (2007) Antibodycatalyzed
oxidation of delta(9)-tetrahydrocannabinol. J. Am. Chem. Soc. 129(12): 3698-
702.
2421. Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G,
Vanderwal CD, Day BW, Sorensen EJ, Lopez JA, Andreu JM, Hamel E, Diaz JF. (2007)
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.
Nat. Chem. Biol. 3(2): 117-25.
2422. Capkova K, Yoneda Y, Dickerson TJ, Janda KD. (2007) Synthesis and structureactivity
relationships of second-generation hydroxamate botulinum neurotoxin a
protease inhibitors. Bioorg. Med. Chem. Lett. 17(23): 6463-6.
2423. Cardoso RMF, Brunel FM, Ferguson S, Zwick M, Burton DR, Dawson PE, Wilson
IA. (2007) Structural basis of enhanced binding of extended and helically constrained
peptide epitopes of the broadly neutralizing hiv-1 antibody 4e10. J. Mol. Biol. 365(5):
1533-44.
2424. Carlson EE, Cravatt BF. (2007) Enrichment tags for enhanced-resolution profiling
of the polar metabolome. J. Am. Chem. Soc. 129(51): 15780-+.
2425. Carlson EE, Cravatt BF. (2007) Chemoselective probes for metabolite
enrichment and profiling. Nat. Methods. 4(5): 429-35.
2426. Cass CL, Johnson JR, Califf LL, Xu T, Hernandez HJ, Stadecker MJ, Yates JR,
Williams DL. (2007) Proteomic analysis of schistosoma mansoni egg secretions. Mol.

Biochem. Parasitol. 155(2): 84-93.
2427. Chamero P, Marton TF, Logan DW, Flanagan K, Cruz JR, Saghatelian A, Cravatt
BF, Stowers L. (2007) Identification of protein pheromones that promote aggressive
behaviour. Nature. 450(7171): 899-U23.
2428. Chan TR, Fokin VV. (2007) Polymer-supported copper(i) catalysts for the
experimentally simplified azide-alkyne cycloaddition. QSAR Comb. Sci. 26(11-12):
1274-9.
2429. Chang BS, Chen Y, Zhao YM, Bruick RK. (2007) Jmjd6 is a histone arginine
demethylase. Science. 318(5849): 444-7.
2430. Chang YJ, Huang JR, Tsai YC, Hung JT, Wu D, Fujio M, Wong CH, Yu AL.
(2007) Potent immune-modulating and anticancer effects of nkt cell stimulatory
glycolipids. Proc. Natl. Acad. Sci. U. S. A. 104(25): 10299-304.
2431. Chen SB, Takanashi SC, Zhang QS, Xiong W, Zhu ST, Peters EC, Ding S,
Schultz PG. (2007) Reversine increases the plasticity of lineage-committed mammalian
cells. Proc. Natl. Acad. Sci. U. S. A. 104(25): 10482-7.
2432. Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SGF, Thian FS, Kobilka
TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC. (2007) High-resolution crystal
structure of an engineered human beta(2)-adrenergic g protein-coupled receptor.
Science. 318(5854): 1258-65.
2433. Chi YG, English EP, Pomerantz WC, Horne WS, Joyce LA, Alexander LR,
Fleming WS, Hopkins EA, Gellman SH. (2007) Practical synthesis of enantiomerically
pure beta(2)-amino acids via proline-catalyzed diastereoselective aminomethylation of
aldehydes. J. Am. Chem. Soc. 129(18): 6050-5.
2434. Chiu G, Li SJ, Cai H, Connolly PJ, Peng S, Stauber K, Pulito V, Liu JC, Middleton
SA. (2007) Aminocyclohexylsulfonamides: Discovery of metabolically stable
alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of benign
prostatic hyperplasia/lower urinary tract symptoms (bph/luts). Bioorg. Med. Chem. Lett.
17(22): 6123-8.
2435. Chromy BA, Arroyo E, Blanchette CD, Bench G, Benner H, Cappuccio JA,
Coleman MA, Henderson PT, Hinz AK, Kuhn EA, Pesavento JB, Segelke BW, Sulchek
TA, Tarasow T, Walsworth VL, Hoeprich PD. (2007) Different apolipoproteins impact
nanolipoprotein particle formation. J. Am. Chem. Soc. 129(46): 14348-54.
2436. Chueh BH, Huh D, Kyrtsos CR, Houssin T, Futai N, Takayama S. (2007)
Leakage-free bonding of porous membranes into layered microfluidic array systems.
Anal. Chem. 79(9): 3504-8.
2437. Cirz RT, Jones MB, Gingles NA, Minogue TD, Jarrahi B, Peterson SN,
Romesberg FE. (2007) Complete and sos-mediated response of staphylococcus aureus
to the antibiotic ciprofloxacin. J. Bacteriol. 189(2): 531-9.
2438. Cirz RT, Romesberg FE. (2007) Controlling mutation: Intervening in evolution as
a therapeutic strategy. Crit. Rev. Biochem. Mol. Biol. 42(5): 341-54.
2439. Clapp AR, Pons T, Medintz IL, Delehanty JB, Melinger JS, Tiefenbrunn T,
Dawson PE, Fisher BR, O'Rourke B, Mattoussi H. (2007) Two-photon excitation of
quantum-dot-based fluorescence resonance energy transfer and its applications. Adv.
Mater. 19(15): 1921-+.

2440. Coleman PJ, Schreler JD, Cox CD, Fraley ME, Garbaccio RM, Buser CA, Walsh
ES, Hamilton K, Lobell RB, Rickert K, Tao WK, Diehl RE, South VJ, Davide JP, Kohl
NE, Yan YW, Kuo L, Prueksaritanont T, Li CZ, Mahan EA, Fernandez-Metzler C, Salata
JJ, Hartman GD. (2007) Kinesin spindle protein (ksp) inhibitors. Part 6: Design and
synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic
kinesin ksp. Bioorg. Med. Chem. Lett. 17(19): 5390-5.
2441. Coureux PD, Genick UK. (2007) Triggering and monitoring light-sensing
reactions in protein crystals. Methods Enzymol. 422: 305-37.
2442. Cox CD, Breslin MJ, Whitman DB, Coleman PJ, Garbaccio RM, Fraley ME,
Zrada MM, Buser CA, Walsh ES, Hamilton K, Lobell RB, Tao WK, Abrams MT, South
VJ, Huber HE, Kohl NE, Hartman GD. (2007) Kinesin spindle protein (ksp) inhibitors.
Part v: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, watersoluble
ksp inhibitors, and modulation of their basicity by beta-fluorination to overcome
cellular efflux by p-glycoprotein. Bioorg. Med. Chem. Lett. 17(10): 2697-702.
2443. Cravatt BF, Simon GM, Yates JR. (2007) The biological impact of massspectrometry-based
proteomics. Nature. 450(7172): 991-1000.
2444. Dakas PY, Barluenga S, Totzke F, Zirrgiebel U, Winssinger N. (2007) Modular
synthesis of radicicol a and related resorcylic acid lactones, potent kinase inhibitors.
Angew. Chem.-Int. Edit. 46(36): 6899-902.
2445. Daniels DS, Petersson EJ, Qiu JX, Schepartz A. (2007) High-resolution structure
of a beta-peptide bundle. J. Am. Chem. Soc. 129(6): 1532-+.
2446. Daniels DS, Schepartz A. (2007) Intrinsically cell-permeable miniature proteins
based on a minimal cationic ppii motif. J. Am. Chem. Soc. 129(47): 14578-+.
2447. Danilova O, Li B, Szardenings AK, Huber BT, Rosenblum JS. (2007) Synthesis
and activity of a potent, specific azabicyclo[3.3.0]-octane-based dpp ii inhibitor. Bioorg.
Med. Chem. Lett. 17(2): 507-10.
2448. Dann FJ, Gottlieb AB, Deepe GS, Flynn JL, Wallis RS, Thompson EHZ, Louie
JS. (2007) Structural-functional relationships of tnf-alpha antagonists: Next steps. J.
Invest. Dermatol. Symp. Proc. 12(1): 46-7.
2449. Debler EW, Kaufmann GF, Kirchdoerfer RN, Mee JM, Janda KD, Wilson IA.
(2007) Crystal structures of a quorum-quenching antibody. J. Mol. Biol. 368(5): 1392-
402.
2450. Denby L, Work LM, Von Seggern DJ, Wu E, McVey JH, Nicklin SA, Baker AH.
(2007) Development of renal-targeted vectors through combined in vivo phage display
and capsid engineering of adenoviral fibers from serotype 19p. Mol. Ther. 15(9): 1647-
54.
2451. Dhar TGM, Wrobleski ST, Lin S, Furch JA, Nirschl DS, Fan Y, Todderud G, Pitt
S, Doweyko AM, Sack JS, Mathur A, McKinnon M, Barrish JC, Dodd JH, Schieven GL,
Leftheris K. (2007) Synthesis and sar of p38 alpha map kinase inhibitors based on
heterobicyclic scaffolds. Bioorg. Med. Chem. Lett. 17(18): 5019-24.
2452. Dhillon AK, Donners H, Pantophlet R, Johnson WE, Decker JM, Shaw GM, Lee
FH, Richman DD, Doms RW, Vanham G, Burton DR. (2007) Dissecting the neutralizing
antibody-specificities of broadly neutralizing sera from human immunodeficiency virus
type 1-infected donors. J. Virol. 81(12): 6548-62.

2453. Dias DP, Marenco RA. (2007) Photosynthesis and photoinhibition in mahogany
and acariquara as a function of irradiance and leaf temperature. Pesqui. Agropecu.
Bras. 42(3): 305-11.
2454. Dias DP, Marenco RA. (2007) Fluorescence characteristics and photoinhibition in
saplings of manwood on clear days and under overcast conditions. Sci. Agric. 64(6):
595-600.
2455. Dickerson TJ, McKenzie KM, Hoyt AS, Wood MR, Janda KD, Brenner SB, Lerner
RA. (2007) Phage escape libraries for checkmate analysis. Proc. Natl. Acad. Sci. U. S.
A. 104(31): 12703-8.
2456. Dierks C, Grbic J, Zirlik K, Beigi R, Englund NP, Guo GR, Veelken H, Engelhardt
M, Mertelsmann R, Kelleher JF, Schultz P, Warmuth M. (2007) Essential role of
stromally induced hedgehog signaling in b-cell malignancies. Nat. Med. 13(8): 944-51.
2457. Dong H, Hartgerink JD. (2007) Role of hydrophobic clusters in the stability of
alpha-helical coiled coils and their conversion to amyloid-like beta-sheets.
Biomacromolecules. 8(2): 617-23.
2458. Dong H, Paramonov SE, Aulisa L, Bakota EL, Hartgerink JD. (2007) Selfassembly
of multidomain peptides: Balancing molecular frustration controls
conformation and nanostructure. J. Am. Chem. Soc. 129(41): 12468-72.
2459. Dong MQ, Venable JD, Au N, Xu T, Park SK, Cociorva D, Johnson JR, Dillin A,
Yates JR. (2007) Quantitative mass spectrometry identifies insulin signaling targets in celegans.
Science. 317(5838): 660-3.
2460. Dorrell M, Uusitalo-Jarvinen H, Aguilar E, Friedlander M. (2007) Ocular
neovascularization: Basic mechanisms and therapeutic advances. Surv. Ophthalmol.
52: S3-S19.
2461. Dorrell MI, Aguilar E, Scheppke L, Barnett FH, Friedlander M. (2007)
Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis.
Proc. Natl. Acad. Sci. U. S. A. 104(3): 967-72.
2462. Emre N, Coleman R, Ding S. (2007) A chemical approach to stem cell biology.
Curr. Opin. Chem. Biol. 11(3): 252-8.
2463. Estebanez-Perpina E, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R,
Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. (2007) A surface on
the androgen receptor that allosterically regulates coactivator binding. Proc. Natl. Acad.
Sci. U. S. A. 104(41): 16074-9.
2464. Estebanez-Perpina E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E,
Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. (2007) Structural
insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid
hormone receptor. Mol. Endocrinol. 21(12): 2919-28.
2465. Eubanks LM, Dickerson TJ. (2007) Investigating novel therapeutic targets and
molecular mechanisms to treat botulinum neurotoxin a intoxication. Future Microbiol.
2(6): 677-87.
2466. Eubanks LM, Dickerson TJ, Janda KD. (2007) Technological advancements for
the detection of and protection against biological and chemical warfare agents. Chem.
Soc. Rev. 36(3): 458-70.
2467. Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, Baldwin MR,

Malizio CJ, Goodnough MC, Barbieri JT, Johnson EA, Boger DL, Dickerson TJ, Janda
KD. (2007) An in vitro and in vivo disconnect uncovered through high-throughput
identification of botulinum neurotoxin a antagonists. Proc. Natl. Acad. Sci. U. S. A.
104(8): 2602-7.
2468. Evans MJ, Morris GM, Wu J, Olson AJ, Sorensen EJ, Cravatt BF. (2007)
Mechanistic and structural requirements for active site labeling of phosphoglycerate
mutase by spiroepoxides. Mol. Biosyst. 3(7): 495-506.
2469. Everley PA, Gartner CA, Haas W, Saghatelian A, Elias JE, Cravatt BF, Zetter
BR, Gygi SP. (2007) Assessing enzyme activities using stable isotope labeling and
mass spectrometry. Mol. Cell. Proteomics. 6(10): 1771-7.
2470. Favor DA, Johnson DS, Powers JJ, Li TS, Madabattula R. (2007) Synthesis of
chromanyl and dihydrobenzofuranyl piperazines. Tetrahedron Lett. 48(17): 3039-41.
2471. Fischer N, Tarasow TM, Tok JBH. (2007) Aptasensors for biosecurity
applications. Curr. Opin. Chem. Biol. 11(3): 316-28.
2472. Fischer NO, Tarasow TM, Tok JBH. (2007) Heightened sense for sensing:
Recent advances in pathogen immunoassay sensing platforms. Analyst. 132(3): 187-
91.
2473. Foley TL, Burkart MD. (2007) Site-specific protein modification: Advances and
applications. Curr. Opin. Chem. Biol. 11(1): 12-9.
2474. Fowler DM, Koulov AV, Balch WE, Kelly JW. (2007) Functional amyloid - from
bacteria to humans. Trends Biochem.Sci. 32(5): 217-24.
2475. Fu J, Astarita G, Gaetani S, Kim J, Cravatt BF, Mackie K, Piomelli D. (2007)
Food intake regulates oleoylethanolamide formation and degradation in the proximal
small intestine. J. Biol. Chem. 282(2): 1518-28.
2476. Fujii N, Haresco JJ, Novak KAP, Gage RM, Pedemonte N, Stokoe D, Kuntz ID,
Guy RK. (2007) Rational design of a nonpeptide general chemical scaffold for reversible
inhibition of pdz domain interactions. Bioorg. Med. Chem. Lett. 17(2): 549-52.
2477. Fujii N, Shelat A, Hall RA, Guy RK. (2007) Design of a selective chemical probe
for class ipdz domains. Bioorg. Med. Chem. Lett. 17(2): 546-8.
2478. Fujii N, You L, Xu ZD, Uematsu K, Shan JF, He B, Mikami I, Edmondson LR,
Neale G, Zheng J, Guy RK, Jablons DM. (2007) An antagonist of dishevelled proteinprotein
interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Res.
67(2): 573-9.
2479. Galkin AV, Mellnick JS, Kim S, Hood TL, Li NX, Li LT, Xia G, Steensma R,
Chopiuk G, Jiang JQ, Wan YQ, Ding P, Liu Y, Sun FX, Schultz PG, Gray NS, Warmuth
M. (2007) Identification of nvp-tae684, a potent, selective, and efficacious inhibitor of
npm-alk. Proc. Natl. Acad. Sci. U. S. A. 104(1): 270-5.
2480. Garbaccio RM, Huang S, Tasber ES, Fraley ME, Yan YW, Munshi S, Ikuta M,
Kuo L, Kreatsoulas C, Stirdivant S, Drakas B, Rickert K, Walsh ES, Hamilton KA, Buser
CA, Hardwick J, Mao XZ, Beck SC, Abrams MT, Tao WK, Lobell R, Sepp-Lorenzino L,
Hartman GD. (2007) Synthesis and evaluation of substituted benzoisoquinolinones as
potent inhibitors of chk1 kinase. Bioorg. Med. Chem. Lett. 17(22): 6280-5.
2481. Garbaccio RM, Tasbera ES, Neilson LA, Coleman PJ, Fraley ME, Olson C,
Bergman J, Torrent M, Buser CA, Rickert K, Walsh ES, Hamilton K, Lobell RB, Tao WK,

South VJ, Diehl RE, Davide JP, Yan YW, Kuo LC, Li CZ, Prueksaritanont T, Fernandez-
Metzler C, Mahan EA, Slaughter DE, Salata JJ, Kohl NE, Huber HE, Hartman GD.
(2007) Kinesin spindle protein (ksp) inhibitors. Part 7: Design and synthesis of 3,3disubstituted
dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin
ksp. Bioorg. Med. Chem. Lett. 17(20): 5671-6.
2482. Gauba V, Hartgerink JD. (2007) Surprisingly high stability of collagen abc
heterotrimer: Evaluation of side chain charge pairs. J. Am. Chem. Soc. 129(48): 15034-
41.
2483. Gauba V, Hartgerink JD. (2007) Self-assembled heterotrimeric collagen triple
helices directed through electrostatic interactions. J. Am. Chem. Soc. 129(9): 2683-90.
2484. Genick UK. (2007) Structure-factor extrapolation using the scalar approximation:
Theory, applications and limitations. Acta Crystallogr. Sect. D-Biol. Crystallogr. 63:
1029-41.
2485. Gong X, Cheng C, Xia CH. (2007) Connexins in lens development and
cataractogenesis. J. Membr. Biol. 218(1-3): 9-12.
2486. Goodman JL, Petersson EJ, Daniels DS, Qiu JX, Schepartz A. (2007)
Biophysical and structural characterization of a robust octameric beta-peptide bundle. J.
Am. Chem. Soc. 129(47): 14746-51.
2487. Grube A, Immel S, Baran PS, Kock M. (2007) Massadine chloride: A biosynthetic
precursor of massadine and stylissadine. Angew. Chem.-Int. Edit. 46(35): 6721-4.
2488. Gu W, Chen H, Tung YC, Meiners JC, Takayama S. (2007) Multiplexed hydraulic
valve actuation using ionic liquid filled soft channels and braille displays. Appl. Phys.
Lett. 90(3): 3.
2489. Gupton SL, Eisenmann K, Alberts AS, Waterman-Storer CM. (2007) Mdia2
regulates actin and focal adhesion dynamics and organization in the lamella for efficient
epithelial cell migration. J. Cell Sci. 120(19): 3475-87.
2490. Guvench O, Qu CK, MacKerell AD. (2007) Tyr66 acts as a conformational switch
in the closed-to-open transition of the shp-2n-sh2-domain phosphotyrosine-peptide
binding cleft. BMC Struct. Biol. 7: 18.
2491. Guy RK. (2007) Cures for neglected diseases: Alternative strategies for finding
drugs. Curr. Opin. Chem. Biol. 11(4): 410-1.
2492. Hanna ML, Tarasow TM, Perkins J. (2007) Mechanistic differences between in
vitro assays for hydrazone-based small molecule inhibitors of anthrax lethal factor.
Bioorg. Chem. 35(1): 50-8.
2493. Hanson MA, Brooun A, Baker KA, Jaakola VP, Roth C, Chien EYT, Alexandrov
A, Velasquez J, Davis L, Griffith M, Moy K, Ganser-Pornillos BK, Hua Y, Kuhn P, Ellis S,
Yeager M, Stevens RC. (2007) Profiling of membrane protein variants in a baculovirus
system by coupling cell-surface detection with small-scale parallel expression. Protein
Expr. Purif. 56(1): 85-92.
2494. Hanson SR, Greenberg WA, Wong CH. (2007) Probing glycans with the
copper(i)-catalyzed [3+2] azide-alkyne cycloaddition. QSAR Comb. Sci. 26(11-12):
1243-52.
2495. Hanson SR, Hsu TL, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong
CH. (2007) Tailored glycoproteomics and glycan site mapping using saccharide-

selective bioorthogonal probes. J. Am. Chem. Soc. 129(23): 7266-+.
2496. Hardouin C, Kelso MJ, Romero FA, Rayl TJ, Leung D, Hwang I, Cravatt BF,
Boger DL. (2007) Structure-activity relationships of alpha-ketooxazole inhibitors of fatty
acid amide hydrolase. J. Med. Chem. 50(14): 3359-68.
2497. Heaslet H, Rosenfeld R, Giffin M, Lin YC, Tam K, Torbett BE, Elder JH, McRee
DE, Stout CD. (2007) Conformational flexibility in the flap domains of ligand-free hiv
protease. Acta Crystallogr. Sect. D-Biol. Crystallogr. 63: 866-75.
2498. Hecht D, Fogel GB. (2007) High-throughput ligand screening via preclustering
and evolved neural networks. IEEE-ACM Trans. Comput. Biol. Bioinform. 4(3): 476-84.
2499. Heideker J, Lis ET, Romesberg FE. (2007) Phosphatases, DNA damage
checkpoints and checkpoint deactivation. Cell Cycle. 6(24): 3058-64.
2500. Heo YS, Cabrera LM, Song JW, Futai N, Tung YC, Smith GD, Takayama S.
(2007) Characterization and resolution of evaporation-mediated osmolality shifts that
constrain microfluidic cell culture in poly(dimethylsiloxane) devices. Anal. Chem. 79(3):
1126-34.
2501. Hicks JD, Huh CW, Legg AD, Roush WR. (2007) Concerning the selective
protection of (z)-1,5-syn-ene-diols and (e)-1,5-anti-ene-diols as allylic triethylsilyl ethers.
Org. Lett. 9(26): 5621-4.
2502. Hills RD, Brooks CL. (2007) Hydrophobic cooperativity as a mechanism for
amyloid nucleation. J. Mol. Biol. 368(3): 894-901.
2503. Hong JY, Lee J, Min KH, Walker JR, Peters EC, Gray NS, Cho CY, Schultz PG.
(2007) Identification and characterization of small-molecule inducers of epidermal
keratinocyte differentiation. ACS Chem. Biol. 2(3): 171-5.
2504. Horne WS, Price JL, Keck JL, Gellman SH. (2007) Helix bundle quaternary
structure from alpha/beta-peptide foldamers. J. Am. Chem. Soc. 129(14): 4178-+.
2505. Horwich AL, Fenton WA, Chapman E, Farr GW. (2007) Two families of
chaperonin: Physiology and mechanism. Annu. Rev. Cell Dev. Biol. 23: 115-45.
2506. Hsu TL, Hanson SR, Kishikawa K, Wang SK, Sawa M, Wong CH. (2007) Alkynyl
sugar analogs for the labeling and visualization of glycoconjugates in cells. Proc. Natl.
Acad. Sci. U. S. A. 104(8): 2614-9.
2507. Huang KT, Winssinger N. (2007) Ipy2bf4-mediated glycosylation and glycosyl
fluoride formation. Eur. J. Org. Chem. (12): 1887-90.
2508. Huh D, Bahng JH, Ling YB, Wei HH, Kripfgans OD, Fowlkes JB, Grotberg JB,
Takayama S. (2007) Gravity-driven microfluidic particle sorting device with
hydrodynamic separation amplification. Anal. Chem. 79(4): 1369-76.
2509. Huh D, Fujioka H, Tung YC, Futai N, Paine R, Grotberg JB, Takayama S. (2007)
Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in
microfluidic airway systems. Proc. Natl. Acad. Sci. U. S. A. 104(48): 18886-91.
2510. Huh D, Mills KL, Zhu XY, Burns MA, Thouless MD, Takayama S. (2007)
Tuneable elastomeric nanochannels for nanofluidic manipulation. Nat. Mater. 6(6): 424-
8.
2511. Hwang SR, O'Neill A, Bark S, Foulon T, Hook V. (2007) Secretory vesicle
aminopeptidase b related to neuropeptide processing: Molecular identification and
subcellular localization to enkephalin- and npy-containing chromaffin granules. J.

Neurochem. 100(5): 1340-50.
2512. Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR,
Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM. (2007) Planarity and
constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition
of human carboxylesterase 1. J. Med. Chem. 50(23): 5727-34.
2513. Inamdar MV, Kim T, Chung YK, Was AM, Xiang X, Wang CW, Takayama S,
Lastoskie CM, Thomas FIM, Sastry AM. (2007) Assessment of sperm chemokinesis
with exposure to jelly coats of sea urchin eggs and resact: A microfluidic experiment and
numerical study. J. Exp. Biol. 210(21): 3805-20.
2514. Inglese J, Shamu CE, Guy RK. (2007) Reporting data from high-throughput
screening of small-molecule libraries. Nat. Chem. Biol. 3(8): 438-41.
2515. Ino A, Dickerson TJ, Janda KD. (2007) Positional linker effects in haptens for
cocaine immunopharmacotherapy. Bioorg. Med. Chem. Lett. 17(15): 4280-3.
2516. Jaqaman K, Dorn JF, Marco E, Sorger PK, Danuser G. (2007) Phenotypic
clustering of yeast mutants based on kinetochore microtubule dynamics. Bioinformatics.
23(13): 1666-73.
2517. Jin W, Trzupek JD, Rayl TJ, Broward MA, Vielhauer GA, Weir SJ, Hwang I,
Boger DL. (2007) A unique class of duocarmycin and cc-1065 analogues subject to
reductive activation. J. Am. Chem. Soc. 129(49): 15391-7.
2518. Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ. (2007) Interaction
between the androgen receptor and a segment of its corepressor shp. Acta Crystallogr.
Sect. D-Biol. Crystallogr. 63: 1198-200.
2519. Kaltgrad E, Sen Gupta S, Punna S, Huang CY, Chang A, Wong CH, Finn MG,
Blixt O. (2007) Anti-carbohydrate antibodies elicited by polyvalent display on a viral
scaffold. Chembiochem. 8(12): 1455-62.
2520. Kazmierczak P, Sakaguchi H, Tokita J, Wilson-Kubalek EM, Milligan RA, Muller
U, Kachar B. (2007) Cadherin 23 and protocadherin 15 interact to form tip-link filaments
in sensory hair cells. Nature. 449(7158): 87-U59.
2521. Keck JM, Summers MK, Tedesco D, Ekholm-Reed S, Chuang LC, Jackson PK,
Reed SI. (2007) Cyclin e overexpression impairs progression through mitosis by
inhibiting apc(cdh1). J. Cell Biol. 178(3): 371-85.
2522. Kelker MS, Dancheck B, Ju TT, Kessler RP, Hudak J, Nairn AC, Peti W. (2007)
Structural basis for spinophilin-neurabin receptor interaction. Biochemistry. 46(9): 2333-
44.
2523. Kelly WL, Boyne MT, Yeh E, Vosburg DA, Galonic DP, Kelleher NL, Walsh CT.
(2007) Characterization of the aminocarboxycyclopropane-forming enzyme cmac.
Biochemistry. 46(2): 359-68.
2524. Khidekel N, Ficarro SB, Clark PM, Bryan MC, Swaney DL, Rexach JE, Sun YE,
Coon JJ, Peters EC, Hsieh-Wilson LC. (2007) Probing the dynamics of o-glcnac
glycosylation in the brain using quantitative proteomics. Nat. Chem. Biol. 3(6): 339-48.
2525. Kim HS, Wooten CM, Park Y, Hong JY. (2007) Stereoselective synthesis of
tetrahydrofuran lignans via bf3 center dot oet2-promoted reductive
deoxygenation/epimerization of cyclic hemiketal: Synthesis of (-)-odoratisol c, (-)futokadsurin
a, (-)-veraguensin, (+)-fragransin a(2), (+)-galbelgin, and (+)-talaumidin.

Org. Lett. 9(20): 3965-8.
2526. Kim YS, Yoon CH, Kim KJ, Lee YH. (2007) Surface modification of porous
nanocrystalline tio2 films for dye-sensitized solar cell application by various gas
plasmas. J. Vac. Sci. Technol. A. 25(4): 1219-25.
2527. Kindt KS, Viswanath V, Macpherson L, Quast K, Hu HZ, Patapoutian A, Schafer
WR. (2007) Caenorhabditis elegans trpa-1 functions in mechanosensation. Nat.
Neurosci. 10(5): 568-77.
2528. Knickerbocker T, Chen JR, Thadhani R, MacBeath G. (2007) An integrated
approach to prognosis using protein microarrays and nonparametric methods. Mol.
Syst. Biol. 3: 8.
2529. Kock M, Grube A, Seiple IB, Baran PS. (2007) The pursuit of palau'amine.
Angew. Chem.-Int. Edit. 46(35): 6586-94.
2530. Kolodner RD, Mendillo ML, Putnam CD. (2007) Coupling distant sites in DNA
during DNA mismatch repair. Proc. Natl. Acad. Sci. U. S. A. 104(32): 12953-4.
2531. Kozlov SV, Bogenpohl JW, Howell MP, Wevrick R, Panda S, Hogenesch JB,
Muglia LJ, Van Gelder RN, Herzog ED, Stewart CL. (2007) The imprinted gene magel2
regulates normal circadian output. Nature Genet. 39(10): 1266-72.
2532. Kresge N. (2007) One hundred years of the american society for biochemistry
and molecular biology. IUBMB Life. 59(4-5): 221-3.
2533. Larsen NA, Al-Bassam J, Wei RR, Harrison SC. (2007) Structural analysis of
bub3 interactions in the mitotic spindle checkpoint. Proc. Natl. Acad. Sci. U. S. A.
104(4): 1201-6.
2534. Larsen SD, Poel TJ, Filipski KJ, Kohrt JT, Pfefferkorn JA, Sorenson RJ, Tait BD,
Askew V, Dillon L, Hanselman JC, Lu GH, Robertson A, Sekerke C, Kowala MC,
Auerbach BJ. (2007) Pyrazole inhibitors of hmg-coa reductase: An attempt to
dramatically reduce synthetic complexity through minimal analog re-design. Bioorg.
Med. Chem. Lett. 17(20): 5567-72.
2535. Le-Niculescu H, Balaraman Y, Patel S, Tan J, Sidhu K, Jerome RE, Edenberg
HJ, Kuczenski R, Geyer MA, Nurnberger JI, Faraone SV, Tsuang MT, Niculescu AB.
(2007) Towards understanding the schizophrenia code: An expanded convergent
functional genomics approach. Am. J. Med. Genet. B. 144B(2): 129-58.
2536. Le-Niculescu H, McFarland MJ, Mamidipalli S, Ogden CA, Kuczenski R, Kurian
SM, Salomon DR, Tsuang MT, Nurnberger JI, Niculescu AB. (2007) Convergent
functional genomics of bipolar disorder: From animal model pharmacogenomics to
human genetics and biomarkers. Neurosci. Biobehav. Rev. 31(6): 897-903.
2537. Lee J, Wu X, di Magliano MP, Peters EC, Wang Y, Hong J, Hebrok M, Din S,
Cho CY, Schultz PG. (2007) A small-molecule antagonist of the hedgehog signaling
pathway. Chembiochem. 8(16): 1916-9.
2538. Lee SY, Clark RC, Boger DL. (2007) Total synthesis, stereochemical
reassignment, and absolute configuration of chlorofusin. J. Am. Chem. Soc. 129(32):
9860-+.
2539. Leman LJ, Weinberger DA, Huang ZZ, Wilcoxen KM, Ghadiri MR. (2007)
Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de
novo designed coiled coil peptides via rational active site engineering. J. Am. Chem.

Soc. 129(10): 2959-66.
2540. Li F, Castle SL. (2007) Synthesis of the acutumine spirocycle via a radical-polar
crossover reaction. Org. Lett. 9(20): 4033-6.
2541. Li WW, Blankman JL, Cravatt BF. (2007) A functional proteomic strategy to
discover inhibitors for uncharacterized hydrolases. J. Am. Chem. Soc. 129(31): 9594-+.
2542. Li YY, Zhu FQ, Vaidehi N, Goddard WA, Sheinerman F, Reiling S, Morize I, Mu
L, Harris K, Ardati A, Laoui A. (2007) Prediction of the 3d structure and dynamics of
human dp g-protein coupled receptor bound to an agonist and an antagonist. J. Am.
Chem. Soc. 129(35): 10720-31.
2543. Liang PH, Wang SK, Wong CH. (2007) Quantitative analysis of carbohydrateprotein
interactions using glycan microarrays: Determination of surface and solution
dissociation constants. J. Am. Chem. Soc. 129(36): 11177-84.
2544. Lira R, Roush WR. (2007) Enantio- and diastereoselective synthesis of syn-betahydroxyallylsilanes
via a chiral (z)-gamma-silylailylboronate. Org. Lett. 9(21): 4315-8.
2545. Lira R, Roush WR. (2007) Stereoselective synthesis of the c(1)-c(19) fragment of
tetrafibricin. Org. Lett. 9(3): 533-6.
2546. List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF,
Segre J, Bugge TH. (2007) Autosomal ichthyosis with hypotrichosis syndrome displays
low matriptase proteolytic activity and is phenocopied in st14 hypomorphic mice. J. Biol.
Chem. 282(50): 36714-23.
2547. Littke A, Soumeillant M, Kaltenbach RF, Cherney RJ, Tarby CM, Kiau S. (2007)
Mild and general methods for the palladium-catalyzed cyanation of aryl and heteroaryl
chlorides. Org. Lett. 9(9): 1711-4.
2548. Liu AC, Lewis WG, Kay SA. (2007) Mammalian circadian signaling networks and
therapeutic targets. Nat. Chem. Biol. 3(10): 630-9.
2549. Liu WS, Brock A, Chen S, Chen SB, Schultz PG. (2007) Genetic incorporation of
unnatural amino acids into proteins in mammalian cells. Nat. Methods. 4(3): 239-44.
2550. Liu Y, Steiniger SCJ, Kim Y, Kaufmann GF, Felding-Habermann B, Janda KD.
(2007) Mechanistic studies of a peptidic grp78 ligand for cancer cell-specific drug
delivery. Mol. Pharm. 4(3): 435-47.
2551. Liu YS, Jiang N, Wu JY, Dai W, Rosenblum JS. (2007) Polo-like kinases inhibited
by wortmannin - labeling site and downstream effects. J. Biol. Chem. 282(4): 2505-11.
2552. Liverton NJ, Bednar RA, Bednar B, Butcher JW, Claiborne CF, Claremon DA,
Cunningham M, DiLella AG, Gaul SL, Libby BE, Lyle EA, Lynch JJ, McCauley JA,
Mosser SD, Nguyen KT, Stump GL, Sun H, Wang H, Yergey J, Koblan KS. (2007)
Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2ylamino)methyl]piperidine-1-carboxylate,
an orally bioavailable, brain penetrant nr2b
selective n-methyl-d-aspartate receptor antagonist. J. Med. Chem. 50(4): 807-19.
2553. Lundgren BR, Boddy CN. (2007) Sialic acid and n-acyl sialic acid analog
production by fermentation of metabolically and genetically engineered escherichia coli.
Org. Biomol. Chem. 5(12): 1903-9.
2554. Lyssiotis CA, Walker J, Wu CL, Kondo T, Schultz PG, Wu X. (2007) Inhibition of
histone deacetylase activity induces developmental plasticity in oligodendrocyte
precursor cells. Proc. Natl. Acad. Sci. U. S. A. 104(38): 14982-7.

2555. Ma B, Parkinson JL, Castle SL. (2007) Novel cinchona alkaloid derived
ammonium salts as catalysts for the asymmetric synthesis of beta-hydroxy alpha-amino
acids via aldol reactions. Tetrahedron Lett. 48(12): 2083-6.
2556. Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF,
Patapoutian A. (2007) Noxious compounds activate trpa1 ion channels through covalent
modification of cysteines. Nature. 445(7127): 541-5.
2557. Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B,
Corey DP, Patapoutian A. (2007) An ion channel essential for sensing chemical
damage. J. Neurosci. 27(42): 11412-5.
2558. Mahnke DJ, McDonald R, Hof F. (2007) A shape-dependent hydrophobic effect
for tetrazoles. Chem. Commun. (36): 3738-40.
2559. Maimone TJ, Baran PS. (2007) Modern synthetic efforts toward biologically
active terpenes. Nat. Chem. Biol. 3(7): 396-407.
2560. Mandel AL, Jones BD, La Clair JJ, Burkart MD. (2007) A synthetic entry to
pladienolide b and fd-895. Bioorg. Med. Chem. Lett. 17(18): 5159-64.
2561. Manfredi MG, Ecsedy JA, Meetze KA, Balani SK, Burenkova O, Chen W, Galvin
KM, Hoar KM, Huck JJ, LeRoy PJ, Ray ET, Sells TB, Stringer B, Stroud SG, Vos TJ,
Weatherhead GS, Wysong DR, Zhang MK, Bolen JB, Claiborne CF. (2007) Antitumor
activity of mln8054, an orally active small-molecule inhibitor of aurora a kinase. Proc.
Natl. Acad. Sci. U. S. A. 104(10): 4106-11.
2562. Manuell AL, Beligni MV, Elder JH, Siefker DT, Tran M, Weber A, McDonald TL,
Mayfield SP. (2007) Robust expression of a bioactive mammalian protein in
chlamydomonas chloroplast. Plant Biotechnol. J. 5(3): 402-12.
2563. Manuell AL, Quispe J, Mayfield SP. (2007) Structure of the chloroplast ribosome:
Novel domains for translation regulation. PLoS. Biol. 5(8): 1785-97.
2564. Marin SD, Xu Y, Meijler MM, Janda KD. (2007) Antibody catalyzed hydrolysis of
a quorum sensing signal found in gram-negative bacteria. Bioorg. Med. Chem. Lett.
17(6): 1549-52.
2565. Marin-Navarro J, Manuell AL, Wu J, Mayfield SP. (2007) Chloroplast translation
regulation. Photosynth. Res. 94(2-3): 359-74.
2566. Matsuda S, Fillo JD, Henry AA, Rai P, Wilkens SJ, Dwyer TJ, Geierstanger BH,
Wemmer DE, Schultz PG, Spraggon G, Romesberg FE. (2007) Efforts toward
expansion of the genetic alphabet: Structure and replication of unnatural base pairs. J.
Am. Chem. Soc. 129(34): 10466-73.
2567. Mayfield SP, Manuell AL, Chen S, Wu J, Tran M, Siefker D, Muto M, Marin-
Navarro J. (2007) Chlamydomonas reinhardtii chloroplasts as protein factories. Curr.
Opin. Biotechnol. 18(2): 126-33.
2568. McClurg P, Janes J, Wu CL, Delano DL, Walker JR, Batalov S, Takahashi JS,
Shimomura K, Kohsaka A, Bass J, Wiltshire T, Su AI. (2007) Genomewide association
analysis in diverse inbred mice: Power and population structure. Genetics. 176(1): 675-
83.
2569. McConnell KW, Muenzer JT, Chang KC, Davis CG, McDunn JE, Coopersmith
CM, Hilliard CA, Hotchkiss RS, Grigsby PW, Hunt CR. (2007) Anti-apoptotic peptides
protect against radiation-induced cell death. Biochem. Biophys. Res. Commun. 355(2):

501-7.
2570. McDunn JE, Townsend RR, Cobb JP. (2007) The murine plasma protein
response to polymicrobial intra-abdominal sepsis. Proteom. Clin. Appl. 1(4): 373-86.
2571. McGinness KE, Bolon DN, Kaganovich M, Baker TA, Sauer RT. (2007) Altered
tethering of the sspb adaptor to the clpxp protease causes changes in substrate
delivery. J. Biol. Chem. 282(15): 11465-73.
2572. McKenzie KM, Mee JM, Rogers CJ, Hixon MS, Kaufmann GF, Janda KD. (2007)
Identification and characterization of single chain anti-cocaine catalytic antibodies. J.
Mol. Biol. 365(3): 722-31.
2573. McQuinn K, Hof F, McIndoe JS. (2007) Direct observation of ion evaporation
from a triply charged nanodroplet. Chem. Commun. (40): 4099-101.
2574. Mehta G, Kiel MJ, Lee JW, Kotov N, Linderman JJ, Takayama S. (2007)
Polyelectrolyte-clay-protein layer films on microfluidic pdms bioreactor surfaces for
primary murine bone marrow culture. Adv. Funct. Mater. 17(15): 2701-9.
2575. Mehta G, Mehta K, Sud D, Song JW, Bersano-Begey T, Futai N, Heo YS, Mycek
MA, Linderman JJ, Takayama S. (2007) Quantitative measurement and control of
oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture.
Biomed. Microdevices. 9(2): 123-34.
2576. Mei G, Di Venere A, Gasperi V, Nicolai E, Masuda KR, Finazzi-Agro A, Cravatt
BF, Maccarrone M. (2007) Closing the gate to the active site - effect of the inhibitor
methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of
fatty acid amide hydrolase. J. Biol. Chem. 282(6): 3829-36.
2577. Mendillo ML, Putnam CD, Kolodner RD. (2007) Escherichia coli muts
tetramerization domain structure reveals that stable dimers but not tetramers are
essential for DNA mismatch repair in vivo. J. Biol. Chem. 282(22): 16345-54.
2578. Mercer AC, Burkart MD. (2007) The ubiquitous carrier protein - a window to
metabolite biosynthesis. Nat. Prod. Rep. 24(4): 750-73.
2579. Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB,
Terry A, Salamov A, Fritz-Laylin LK, Marechal-Drouard L, Marshall WF, Qu LH, Nelson
DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren QH, Ferris P, Lindquist E,
Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen
CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernandez E, Fukuzawa H, Gonzalez-Balle
D, Gonzalez-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K,
Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meir I,
Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi
K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riano-Pachon DM, Riekhof
W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer
J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long
JC, Minagawa J, Page MD, Pan JM, Pootakham W, Roje S, Rose A, Stahlberg E,
Terauchi AM, Yang PF, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P,
Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P,
Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo YG, Martinez D, Ngau
WCA, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou KM, Grigoriev IV,
Rokhsar DS, Grossman AR, Chlamydomonas Annotation JGIAT. (2007) The

chlamydomonas genome reveals the evolution of key animal and plant functions.
Science. 318(5848): 245-51.
2580. Miller BH, McDearmon EL, Panda S, Hayes KR, Zhang J, Andrews JL, Antoch
MP, Walker JR, Esser KA, Hogenesch JB, Takahashi JS. (2007) Circadian and clockcontrolled
regulation of the mouse transcriptome and cell proliferation. Proc. Natl. Acad.
Sci. U. S. A. 104(9): 3342-7.
2581. Mills NL, Shelat AA, Guy RK. (2007) Assay optimization and screening of rnaprotein
interactions by alphascreen. J. Biomol. Screen. 12(7): 946-55.
2582. Min J, Kim YK, Cipriani PG, Kang M, Khersonsky SM, Walsh DP, Lee JY,
Niessen S, Yates JR, Gunsalus K, Piano F, Chang YT. (2007) Forward chemical
genetic approach identifies new role for gapdh in insulin signaling. Nat. Chem. Biol. 3(1):
55-9.
2583. Moisan L, Dale TJ, Gombosuren N, Biros SM, Mann E, Hou JL, Crisostomo FP,
Rebek J. (2007) Facile synthesis of pyridazine-based alpha-helix mimetics.
Heterocycles. 73(1): 661-+.
2584. Muller R, Debler EW, Steinmann M, Seebeck FP, Wilson IA, Hilvert D. (2007)
Bifunctional catalysis of proton transfer at an antibody active site. J. Am. Chem. Soc.
129(3): 460-1.
2585. Munch J, Rucker E, Standker L, Adermann K, Goffinet C, Schindler M, Wildum S,
Chinnadurai R, Rajan D, Specht A, Gimenez-Gallego G, Sanchez PC, Fowler DM,
Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG,
Kirchhoff F. (2007) Semen-derived amyloid fibrils drastically enhance hiv infection. Cell.
131(6): 1059-71.
2586. Murphy MB, Hartgerink JD, Goepferich A, Mikos AG. (2007) Synthesis and in
vitro hydroxyapatite binding of peptides conjugated to calcium-binding moieties.
Biomacromolecules. 8(7): 2237-43.
2587. Naidu PS, Varvel SA, Ahn K, Cravatt BF, Martin BR, Lichtman AH. (2007)
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality.
Psychopharmacology. 192(1): 61-70.
2588. Najmabadi P, La Clair JJ, Burkart MD. (2007) A systems perspective to digital
structures in molecular analysis. Org. Biomol. Chem. 5(2): 214-22.
2589. Nangle LA, Zhang W, Xie W, Yang XL, Schimmel P. (2007) Charcot-marie-tooth
disease-associated mutant trna synthetases linked to altered dimer interface and neurite
distribution defect. Proc. Natl. Acad. Sci. U. S. A. 104(27): 11239-44.
2590. Navasardyan T, Adams GS, Ahmidouch A, Angelescu T, Arrington J, Asaturyan
R, Baker OK, Benmouna N, Bertoncini C, Blok HP, Boeglin WU, Bosted PE, Breuer H,
Christy ME, Connell SH, Cui Y, Dalton MM, Danagoulian S, Day D, Dodario T, Dunne
JA, Dutta D, El Khayari N, Ent R, Fenker HC, Frolov VV, Gan L, Gaskell D, Hafidi K,
Hinton W, Holt RJ, Horn T, Huber GM, Hungerford E, Jiang X, Jones M, Joo K,
Kalantarians N, Kelly JJ, Keppel CE, Kubarovski V, Li Y, Liang Y, Malace S, Markowitz
P, McGrath E, McKee P, Meekins DG, Mkrtchyan H, Moziak B, Niculescu G, Niculescu
I, Opper AK, Ostapenko T, Reimer P, Reinhold J, Roche J, Rock SE, Schulte E,
Segbefia E, Smith C, Smith GR, Stoler P, Tadevosyan V, Tang L, Ungaro M, Uzzle A,
Vidakovic S, Villano A, Vulcan WF, Wang M, Warren G, Wesselmann F, Wojtsekhowski

B, Wood SA, Xu C, Yuan L, Zheng X, Zhu H. (2007) Onset of quark-hadron duality in
pion electroproduction. Phys. Rev. Lett. 98(2): 5.
2591. Nayak SK, Jegla T, Panda S. (2007) Role of a novel photopigment, melanopsin,
in behavioral adaptation to light. Cell. Mol. Life Sci. 64(2): 144-54.
2592. Nelson JD, Brunel FM, Jensen R, Crooks ET, Cardoso RMF, Wang M, Hessell A,
Wilson IA, Binley JM, Dawson PE, Burton DR, Zwick MB. (2007) An affinity-enhanced
neutralizing antibody against the membrane-proximal external region of human
immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2f5 and
4e10. J. Virol. 81(8): 4033-43.
2593. Nguyen AD, McDonald JG, Bruick RK, DeBose-Boyd RA. (2007) Hypoxia
stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme a reductase through
accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs. J.
Biol. Chem. 282(37): 27436-46.
2594. Nguyen KT, Claiborne CF, McCauley JA, Libby BE, Claremon DA, Bednar RA,
Mosser SD, Gaul SL, Connolly TM, Condra CL, Bednar B, Stump GL, Lynch JJ, Koblan
KS, Liverton NJ. (2007) Cyclic benzamidines as orally efficacious nr2b-selective nmda
receptor antagonists. Bioorg. Med. Chem. Lett. 17(14): 3997-4000.
2595. Nicolaou KC, Cole KP, Frederick MO, Aversa RJ, Denton RM. (2007) Chemical
synthesis of the ghijk ring system and further experimental support for the originally
assigned structure of maitotoxin. Angew. Chem.-Int. Edit. 46(46): 8875-9.
2596. Nicolaou KC, Frederick MO. (2007) On the structure of maitotoxin. Angew.
Chem.-Int. Edit. 46(28): 5278-82.
2597. Nicolaou KC, Harrison ST. (2007) Total synthesis of abyssomicin c, atropabyssomicin
c, and abyssomicin d: Implications for natural origins of atrop-abyssomicin
c. J. Am. Chem. Soc. 129(2): 429-40.
2598. Nomura Y, Yokobayashi Y. (2007) Dual selection of a genetic switch by a single
selection marker. Biosystems. 90(1): 115-20.
2599. Nomura Y, Yokobayashi Y. (2007) Reengineering a natural riboswitch by dual
genetic selection. J. Am. Chem. Soc. 129(45): 13814-+.
2600. O'Malley DP, Li K, Maue M, Zografos AL, Baran PS. (2007) Total synthesis of
dimeric pyrrole-imidazole alkaloids: Sceptrin, ageliferin, nagelamide e, oxysceptrin,
nakamuric acid, and the axinellamine carbon skeleton. J. Am. Chem. Soc. 129(15):
4762-75.
2601. O'Neill BM, Szyjka SJ, Lis ET, Bailey AO, Yates JR, Aparicio OM, Romesberg
FE. (2007) Pph3-psy2 is a phosphatase complex required for rad53 dephosphorylation
and replication fork restart during recovery from DNA damage. Proc. Natl. Acad. Sci. U.
S. A. 104(22): 9290-5.
2602. Ostash B, Saghatelian A, Walker S. (2007) A streamlined metabolic pathway for
the biosynthesis of moenomycin a. Chem. Biol. 14(3): 257-67.
2603. Ozer A, Bruick RK. (2007) Non-heme dioxygenases: Cellular sensors and
regulators jelly rolled into one? Nat. Chem. Biol. 3(3): 144-53.
2604. Palenik B, Grimwood J, Aerts A, Rouze P, Salamov A, Putnam N, Dupont C,
Jorgensen R, Derelle E, Rombauts S, Zhou KM, Otillar R, Merchant SS, Podell S,
Gaasterland T, Napoli C, Gendler K, Manuell A, Tai V, Vallon O, Piganeau G, Jancek S,

Heijde M, Jabbari K, Bowler C, Lohr M, Robbens S, Werner G, Dubchak I, Pazour GJ,
Ren QH, Paulsen I, Delwiche C, Schmutz J, Rokhsar D, Van de Peer Y, Moreau H,
Grigoriev IV. (2007) The tiny eukaryote ostreococcus provides genomic insights into the
paradox of plankton speciation. Proc. Natl. Acad. Sci. U. S. A. 104(18): 7705-10.
2605. Palmer LC, Velichko YS, de la Cruz MO, Stupp SI. (2007) Supramolecular selfassembly
codes for functional structures. Philos. Trans. R. Soc. A-Math. Phys. Eng. Sci.
365(1855): 1417-33.
2606. Panda S. (2007) Multiple photopigments entrain the mammalian circadian
oscillator. Neuron. 53(5): 619-21.
2607. Park J, Jagasia R, Kaufmann GF, Mathison JC, Ruiz DI, Moss JA, Meijler MM,
Ulevitch RJ, Janda KD. (2007) Infection control by antibody disruption of bacterial
quorum sensing signaling. Chem. Biol. 14(10): 1119-27.
2608. Patricelli MP, Szardenings AK, Liyanage M, Nomanbhoy TK, Wu M, Weissig H,
Aban A, Chun D, Tanner S, Kozarich JW. (2007) Functional interrogation of the kinome
using nucleotide acyl phosphates. Biochemistry. 46(2): 350-8.
2609. Payne RJ, Ficht S, Tang S, Brik A, Yang YY, Case DA, Wong CH. (2007)
Extended sugar-assisted glycopeptide ligations: Development, scope, and applications.
J. Am. Chem. Soc. 129(44): 13527-36.
2610. Pedrini B, Placzek WJ, Koculi E, Alimenti C, LaTerza A, Luporini P, Wuethrich K.
(2007) Cold-adaptation in sea-water-borne signal proteins: Sequence and nmr structure
of the pheromone en-6 from the antarctic ciliate euplotes nobilii. J. Mol. Biol. 372(2):
277-86.
2611. Petersson EJ, Craig CJ, Daniels DS, Qiu JX, Schepartz A. (2007) Biophysical
characterization of a beta-peptide bundle: Comparison to natural proteins. J. Am. Chem.
Soc. 129(17): 5344-+.
2612. Pfefferkorn JA, Bowles DM, Kissel W, Boyles DC, Choi CL, Larsen SD, Song YT,
Sun KL, Miller SR, Trivedi BK. (2007) Development of a practical synthesis of novel,
pyrrole-based hmg-coa reductase inhibitors. Tetrahedron. 63(34): 8124-34.
2613. Pfefferkorn JA, Choi C, Song Y, Trivedi BK, Larsen SD, Askew V, Dillon L,
Hanselman JC, Lin Z, Lu G, Robertson A, Sekerke C, Auerbach B, Pavlovsky A, Harris
MS, Bainbridge G, Caspers N. (2007) Design and synthesis of novel, conformationally
restricted hmg-coa reductase inhibitors. Bioorg. Med. Chem. Lett. 17(16): 4531-7.
2614. Pfefferkorn JA, Song Y, Sun KL, Miller SR, Trivedi BK, Choi C, Sorenson RJ,
Bratton LD, Unangst PC, Larsen SD, Poel TJ, Cheng XM, Lee C, Erasga N, Auerbach
B, Askew V, Dillon L, Hanselman JC, Lin Z, Lu G, Robertson A, Olsen K, Mertz T,
Sekerke C, Pavlovsky A, Harris MS, Bainbridge G, Caspers N, Chen H, Eberstadt M.
(2007) Design and synthesis of hepatoselective, pyrrole-based hmg-coa reductase
inhibitors. Bioorg. Med. Chem. Lett. 17(16): 4538-44.
2615. Pianowski ZL, Winssinger N. (2007) Fluorescence-based detection of single
nucleotide permutation in DNA via catalytically templated reaction. Chem. Commun.
(37): 3820-2.
2616. Placzek WJ, Almeida MS, Wuthrich K. (2007) Nmr structure and functional
characterization of a human cancer-related nucleoside triphosphatase. J. Mol. Biol.
367(3): 788-801.

2617. Placzek WJ, Etezady-Esfarjani T, Herrmann T, Pedrini B, Peti W, Alimenti C,
Luporini P, Wuthrich K. (2007) Cold-adapted signal proteins: Nmr structures of
pheromones from the antarctic ciliate euplotes nobilii. IUBMB Life. 59(8-9): 578-85.
2618. Pockros PJ, Schiff ER, Shiffman ML, McHutchison JG, Gish RG, Afdhal NH,
Makhviladze M, Huyghe M, Hecht D, Oltersdorf T, Shapiro DA. (2007) Oral idn-6556, an
antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with
chronic hepatitis c. Hepatology. 46(2): 324-9.
2619. Portney NG, Tseng RJ, Destito G, Strable E, Yang Y, Manchester M, Finn MG,
Ozkan M. (2007) Microscale memory characteristics of virus-quantum dot hybrids. Appl.
Phys. Lett. 90(21): 3.
2620. Pothukanuri S, Winssinger N. (2007) A highly efficient azide-based protecting
group for amines and alcohols. Org. Lett. 9(11): 2223-5.
2621. Prasuhn DE, Yeh RM, Obenaus A, Manchester M, Finn MG. (2007) Viral mri
contrast agents: Coordination of gd by native virions and attachment of gd complexes
by azide-alkyne cycloaddition. Chem. Commun. (12): 1269-71.
2622. Price JL, Horne WS, Gellman SH. (2007) Discrete heterogeneous quaternary
structure formed by alpha/beta-peptide foldamers and alpha-peptides. J. Am. Chem.
Soc. 129(20): 6376-+.
2623. Pulivarthy SR, Tanaka N, Welsh DK, De Haro L, Verma IM, Panda S. (2007)
Reciprocity between phase shifts and amplitude changes in the mammalian circadian
clock. Proc. Natl. Acad. Sci. U. S. A. 104(51): 20356-61.
2624. Putnam CD, Hammel M, Hura GL, Tainer JA. (2007) X-ray solution scattering
(saxs) combined with crystallography and computation: Defining accurate
macromolecular structures, conformations and assemblies in solution. Q. Rev. Biophys.
40(3): 191-285.
2625. Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L,
Granger A, Caron L, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans
SM, Ding S, Chien KR. (2007) The renewal and differentiation of isl1(+) cardiovascular
progenitors are controlled by a wnt/beta-catenin pathway. Cell Stem Cell. 1(2): 165-79.
2626. Ramachandran R, Surka M, Chappie JS, Fowler DM, Foss TR, Song BD, Schmid
SL. (2007) The dynamin middle domain is critical for tetramerization and higher-order
self-assembly. Embo J. 26(2): 559-66.
2627. Redmond WL, Gough MJ, Charbonneau B, Ratliff TL, Weinberg AD. (2007)
Defects in the acquisition of cd8 t cell effector function after priming with tumor or
soluble antigen can be overcome by the addition of an ox40 agonist. J. Immunol.
179(11): 7244-53.
2628. Redmond WL, Weinberg AD. (2007) Targeting ox40 and ox40l for the treatment
of autoimmunity and cancer. Crit. Rev. Immunol. 27(5): 415-36.
2629. Ren F, Feldman AK, Carnes M, Steigerwald M, Nuckolls C. (2007) Polymer
growth by functionalized ruthenium nanoparticles. Macromolecules. 40(23): 8151-5.
2630. Repine JT, Johnson DS, Stuk T, White AD, Stier MA, Li T, Yang Z, Maiti SN.
(2007) Synthesis of fluorinated 1,8-naphthyridinone derivatives. Tetrahedron Lett.
48(46): 8189-91.
2631. Repine JT, Johnson DS, White AD, Favor DA, Stier MA, Yip J, Rankin T, Ding

QZ, Maiti SN. (2007) Synthesis of monofluorinated 1-(naphthalen-1-yl)piperazines.
Tetrahedron Lett. 48(31): 5539-41.
2632. Richter JM, Whitefield BW, Maimone TJ, Lin DW, Castroviejo MP, Baran PS.
(2007) Scope and mechanism of direct indole and pyrrole couplings adjacent to
carbonyl compounds: Total synthesis of acremoauxin a and oxazinin 3. J. Am. Chem.
Soc. 129(42): 12857-69.
2633. Roberts TC, Smith PA, Cirz RT, Romesberg FE. (2007) Structural and initial
biological analysis of synthetic arylomycin a(2). J. Am. Chem. Soc. 129(51): 15830-8.
2634. Rodd ZA, Bertsch BA, Strother WN, Le-Niculescu H, Balaraman Y, Hayden E,
Jerome RE, Lumeng L, Nurnberger JI, Edenberg HJ, McBride WJ, Niculescu AB. (2007)
Candidate genes, pathways and mechanisms for alcoholism: An expanded convergent
functional genomics approach. Pharmacogenomics J. 7(4): 222-56.
2635. Rodionov VO, Presolski SI, Diaz DD, Fokin VV, Finn MG. (2007) Ligandaccelerated
cu-catalyzed azide-alkyne cycloaddition: A mechanistic report. J. Am.
Chem. Soc. 129(42): 12705-12.
2636. Rodionov VO, Presolski SI, Gardinier S, Lim YH, Finn MG. (2007) Benzimidazole
and related ligands for cu-catalyzed azide-alkyne cycloaddition. J. Am. Chem. Soc.
129(42): 12696-704.
2637. Rodriguez KH, Roth CR, Rees CJ, Belafsky PC. (2007) Reliability of the
pharyngeal squeeze maneuver. Annals of Otology Rhinology and Laryngology. 116(6):
399-401.
2638. Roecker AJ, Coleman PJ, Mercer SP, Schreier JD, Buser CA, Walsh ES,
Hamilton K, Lobell RB, Tao WK, Diehl RE, South VJ, Davide JP, Kohl NE, Yan YW, Kuo
LC, Li CZ, Fernandez-Metzler C, Mahan EA, Prueksaritanont T, Hartman GD. (2007)
Kinesin spindle protein (ksp) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5dihydropyrazoles
as potent inhibitors of the mitotic kinesin ksp. Bioorg. Med. Chem.
Lett. 17(20): 5677-82.
2639. Romero FA, Du W, Hwang I, Rayl TJ, Kimball FS, Leung D, Hoover HS, Apodaca
RL, Breitenbucher JG, Cravatt BF, Boger DL. (2007) Potent and selective alphaketoheterocycle-based
inhibitors of the anandamide and oleamide catabolizing enzyme,
fatty acid amide hydrolase. J. Med. Chem. 50(5): 1058-68.
2640. Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SGF, Thian FS, Kobilka
TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK. (2007) Gpcr engineering yields
high-resolution structural insights into beta(2)-adrenergic receptor function. Science.
318(5854): 1266-73.
2641. Ruby CE, Redmond WL, Haley D, Weinberg AD. (2007) Anti-ox40 stimulation in
vivo enhances cd8(+) memory t cell survival and significantly increases recall
responses. Eur. J. Immunol. 37(1): 157-66.
2642. Rutten K, Prickaerts J, Hendrix M, van der Staay FJ, Sik A, Blokland A. (2007)
Time-dependent involvement of camp and cgmp in consolidation of object memory:
Studies using selective phosphodiesterase type 2, 4 and 5 inhibitors. Eur. J. Pharmacol.
558(1-3): 107-12.
2643. Sachse C, Chen JZ, Coureux PD, Stroupe ME, Fandrich M, Grigorieff N. (2007)
High-resolution electron microscopy of helical specimens: A fresh look at tobacco

mosaic virus. J. Mol. Biol. 371(3): 812-35.
2644. Salisbury CM, Cravatt BF. (2007) Activity-based probes for proteomic profiling of
histone deacetylase complexes. Proc. Natl. Acad. Sci. U. S. A. 104(4): 1171-6.
2645. Salisbury CM, Cravatt BF. (2007) Click chemistry-led advances in high content
functional proteomics. QSAR Comb. Sci. 26(11-12): 1229-38.
2646. Saphire EM, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R,
Zwick MB, Parren P, Burton DR, Scott JK, Wilson IA. (2007) Structure of a high-affinity
"Mimotope" Peptide bound to hiv-1-neutralizing antibody b12 explains its inability to
elicit gp120 cross-reactive antibodies. J. Mol. Biol. 369(3): 696-709.
2647. Sapsford KE, Pons T, Medintz IL, Higashiya S, Brunel FM, Dawson PE,
Mattoussi H. (2007) Kinetics of metal-affinity driven self-assembly between proteins or
peptides and cdse-zns quantum dots. J. Phys. Chem. C. 111(31): 11528-38.
2648. Saunders AA, Ting JPC, Meisner J, Neuman BW, Perez M, de la Torre JC,
Buchmeier MJ. (2007) Mapping the landscape of the lymphocytic choriomeningitis virus
stable signal peptide reveals novel functional domains. J. Virol. 81(11): 5649-57.
2649. Scheuermann TH, Yang JS, Zhang L, Gardner KH, Bruick RK. (2007) Hypoxiainducible
factors p-er/arnt/s-im domains: Structure and function. Methods Enzymol. 435:
3-+.
2650. Seufert W, Beck ZQ, Sherman DH. (2007) Enzymatic release and
macrolactonization of cryptophycins from a safety-catch solid support. Angew. Chem.-
Int. Edit. 46(48): 9298-300.
2651. Shao YM, Yang WB, Peng HP, Hsu MF, Tsa KC, Kuo TH, Wang AHJ, Liang PH,
Lin CH, Yang AS, Wong CH. (2007) Structure-based design and synthesis of highly
potent sars-cov 3cl protease inhibitors. Chembiochem. 8(14): 1654-7.
2652. Sharma KK, Boddy CN. (2007) The thioesterase domain from the pimaricin and
erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester
substrates. Bioorg. Med. Chem. Lett. 17(11): 3034-7.
2653. Shelat AA, Guy RK. (2007) The interdependence between screening methods
and screening libraries. Curr. Opin. Chem. Biol. 11(3): 244-51.
2654. Shelat AA, Guy RK. (2007) Scaffold composition and biological relevance of
screening libraries. Nat. Chem. Biol. 3(8): 442-6.
2655. Shell SS, Putnam CD, Kolodner RD. (2007) The n terminus of saccharomyces
cerevisiale msh6 is an unstructured tether to pcna. Mol. Cell. 26(4): 565-78.
2656. Shell SS, Putnam CD, Kolodner RD. (2007) Chimeric saccharomyces cerevisiae
msh6 protein with an msh3 mispair-binding domain combines properties of both
proteins. Proc. Natl. Acad. Sci. U. S. A. 104(26): 10956-61.
2657. Silvaggi NR, Boldt GE, Hixon MS, Kennedy JP, Tzipori S, Janda KD, Allen KN.
(2007) Structures of clostridium botulinum neurotoxin serotype a light chain complexed
with small-molecule inhibitors highlight active-site flexibility. Chem. Biol. 14(5): 533-42.
2658. Singh P, Prasuhn D, Yeh RM, Destito G, Rae CS, Osborn K, Finn MG,
Manchester M. (2007) Bio-distribution, toxicity and pathology of cowpea mosaic virus
nanoparticles in vivo. J. Controlled Release. 120(1-2): 41-50.
2659. Smith JA, Vanoye CG, George AL, Meiler J, Sanders CR. (2007) Structural
models for the kcnq1 voltage-gated potassium channel. Biochemistry. 46(49): 14141-52.

2660. Snyder SA, Zografos AL, Lin Y. (2007) Total synthesis of resveratrol-based
natural products: A chemoselective solution. Angew. Chem.-Int. Edit. 46(43): 8186-91.
2661. Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G,
Misteli T. (2007) Positional stability of single double-strand breaks in mammalian cells.
Nat. Cell Biol. 9(6): 675-U121.
2662. Speers AE, Blackler AR, Wu CC. (2007) Shotgun analysis of integral membrane
proteins facilitated by elevated temperature. Anal. Chem. 79(12): 4613-20.
2663. Speers AE, Wu CC. (2007) Proteomics of integral membrane proteins-theory and
application. Chem. Rev. 107(8): 3687-714.
2664. Stiffler MA, Chen JR, Grantcharova VP, Lei Y, Fuchs D, Allen JE, Zaslavskaia
LA, MacBeath G. (2007) Pdz domain binding selectivity is optimized across the mouse
proteome. Science. 317(5836): 364-9.
2665. Stoll R, Lee BM, Debler EW, Laity JH, Wilson IA, Dyson HJ, Wright PE. (2007)
Structure of the wilms tumor suppressor protein zinc finger domain bound to DNA. J.
Mol. Biol. 372(5): 1227-45.
2666. Su AI, Hogenesch JB. (2007) Power-law-like distributions in biomedical
publications and research funding. Genome Biol. 8(4): 2.
2667. Sun Y, Dominy BN, Latour RA. (2007) Comparison of solvation-effect methods
for the simulation of peptide interactions with a hydrophobic surface. J. Comput. Chem.
28(11): 1883-92.
2668. Sutherland JJ, Nandigam RK, Erickson JA, Vieth M. (2007) Lessons in molecular
recognition. 2. Assessing and improving cross-docking accuracy. J. Chem Inf. Model.
47(6): 2293-302.
2669. Suzuki S, Wilson-Kubalek EM, Wert D, Tsao TS, Lee DH. (2007) The oligomeric
structure of high molecular weight adiponectin. FEBS Lett. 581(5): 809-14.
2670. Taga ME, Larsen NA, Howard-Jones AR, Walsh CT, Walker GC. (2007) Blub
cannibalizes flavin to form the lower ligand of vitamin b-12. Nature. 446(7134): 449-53.
2671. Tang C, Ang BT, Pervaiz S. (2007) Cancer stem cell: Target for anti-cancer
therapy. Faseb J. 21(14): 3777-85.
2672. Tang C, Chua CLM, Ang BT. (2007) Insights into the cancer stem cell model of
glioma tumorigenesis. Ann. Acad. Med. Singap. 36(5): 352-7.
2673. Tao J, Burkart MD. (2007) New enzymes for chemical synthesis exploring natural
product biosynthesis. Chim. Oggi-Chem. Today. 25(2): 3-7.
2674. Tellinghuisen TL, Evans MJ, von Hahn T, You S, Rice CM. (2007) Studying
hepatitis c virus: Making the best of a bad virus. J. Virol. 81(17): 8853-67.
2675. Thayer DA, Wong CH. (2007) Enzymatic synthesis of glycopeptides and
glycoproteins. Top. Curr. Chem. 267: 37-63.
2676. Thorpe IF, Brooks CL. (2007) Molecular evolution of affinity and flexibility in the
immune system. Proc. Natl. Acad. Sci. U. S. A. 104(21): 8821-6.
2677. Tichenor MS, MacMillan KS, Stover JS, Wolkenberg SE, Pavani MG, Zanella L,
Zaid AN, Spalluto G, Rayl TJ, Hwang I, Baraldi PG, Boger DL. (2007) Rational design,
synthesis, and evaluation of key analogues of cc-1065 and the duocarmycins. J. Am.
Chem. Soc. 129(45): 14092-9.
2678. Tichenor MS, MacMillan KS, Trzupek JD, Rayl TJ, Hwang I, Boger DL. (2007)

Systematic exploration of the structural features of yatakemycin impacting DNA
alkylation and biological activity. J. Am. Chem. Soc. 129(35): 10858-69.
2679. Torisawa YS, Chueh BH, Huh D, Ramamurthy P, Roth TM, Barald KF,
Takayama S. (2007) Efficient formation of uniform-sized embryoid bodies using a
compartmentalized microchannel device. Lab Chip. 7(6): 770-6.
2680. Treweek J, Wee S, Koob GF, Dickerson TJ, Janda KD. (2007) Self-vaccination
by methamphetamine glycation products chemically links chronic drug abuse and
cardiovascular disease. Proc. Natl. Acad. Sci. U. S. A. 104(28): 11580-4.
2681. Trujillo JI, Huang HC, Neumann WL, Mahoney MW, Long S, Huang W, Garland
DJ, Kusturin C, Abbas Z, South MS, Reitz DB. (2007) Design, synthesis, and biological
evaluation of pyrazinones containing novel p1 needles as inhibitors of tf/viia. Bioorg.
Med. Chem. Lett. 17(16): 4568-74.
2682. Trujillo JI, Meyers MJ, Anderson DR, Hegde S, Mahoney MW, Vernier WF,
Buchler IP, Wu KK, Yang SL, Hartmann SJ, Reitz DB. (2007) Novel tetrahydro-betacarboline-1-carboxylic
acids as inhibitors of mitogen activated protein kinase-activated
protein kinase 2 (mk-2). Bioorg. Med. Chem. Lett. 17(16): 4657-63.
2683. Tubbs JL, Pegg AE, Tainer JA. (2007) DNA binding, nucleotide flipping, and the
helix-turn-helix motif in base repair by o-6-alkylguanine-DNA alkyltransferase and its
implications for cancer chemotherapy. DNA Repair. 6(8): 1100-15.
2684. Tung YC, Torisawa YS, Futai N, Takayama S. (2007) Small volume low
mechanical stress cytometry using computer-controlled braille display microfluidics. Lab
Chip. 7(11): 1497-503.
2685. Va P, Roush WR. (2007) Synthesis of 2-epi-amphidinolide e: An unexpected and
highly selective c(2) inversion during an esterification reaction. Org. Lett. 9(2): 307-10.
2686. Vale C, Gomez-Limia B, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM.
(2007) The c-jun-n-terminal kinase is involved in the neurotoxic effect of azaspiracid-1.
Cell. Physiol. Biochem. 20(6): 957-66.
2687. Vale C, Nicolaou KC, Frederick MO, Gomez-Limia B, Alfonso A, Vieytes MR,
Botana LM. (2007) Effects of azaspiracid-1, a potent cytotoxic agent, on primary
neuronal cultures. A structure-activity relationship study. J. Med. Chem. 50(2): 356-63.
2688. Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg
P, Zobel K, Dynek JN, Elliott LO, Wallweber HJA, Flygare JA, Fairbrother WJ,
Deshayes K, Dixit VM, Vucic D. (2007) Iap antagonists induce autoubiquitination of ciaps,
nf-kappa b activation, and tnf alpha-dependent apoptosis. Cell. 131(4): 669-81.
2689. Varvel SA, Wise LE, Niyuhire F, Cravatt BF, Lichtman AH. (2007) Inhibition of
fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial
memory task. Neuropsychopharmacology. 32(5): 1032-41.
2690. Verkoczy L, Duong B, Skog P, Ait-Azzouzene D, Puri K, Vela JL, Nemazee D.
(2007) Basal b cell receptor-directed phosphatidylinositol 3-kinase signaling turns off
rags and promotes b cell-positive selection. J. Immunol. 178(10): 6332-41.
2691. Vestberg R, Malkoch M, Kade M, Wu P, Fokin VV, Sharpless KB, Drockenmuller
E, Hawker CJ. (2007) Role of architecture and molecular weight in the formation of
tailor-made ultrathin multilayers using dendritic macromolecules and click chemistry. J.
Polym. Sci. Pol. Chem. 45(14): 2835-46.

2692. Viana CE, Dias DP, Paranhos RPD. (2007) Recycling of welding flux slag for the
fabrication of multiple use mortar for the civil construction. Soldagem Insp. 12(1): 38-45.
2693. Vijayakumar S, Chapados BR, Schmidt KH, Kolodner RD, Tainer JA, Tomkinson
AE. (2007) The c-terminal domain of yeast pcna is required for physical and functional
interactions with cdc9 DNA ligase. Nucleic Acids Res. 35(5): 1624-37.
2694. Vilarino N, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. (2007)
Irreversible cytoskeletal disarrangement is independent of caspase activation during in
vitro azaspiracid toxicity in human neuroblastoma cells. Biochem. Pharmacol. 74(2):
327-35.
2695. Wan YH, Saghatelian A, Chong LW, Zhang CL, Cravatt BF, Evans RM. (2007)
Maternal ppar gamma protects nursing neonates by suppressing the production of
inflammatory milk. Genes Dev. 21(15): 1895-908.
2696. Wang HB, Xie HR, Sun XF, Kingsley PJ, Marnett LJ, Cravatt BF, Dey SK. (2007)
Differential regulation of endocannabinoid synthesis and degradation in the uterus
during embryo implantation. Prostaglandins Other Lipid Mediat. 83(1-2): 62-74.
2697. Wang J, Wilcoxen KM, Nomoto K, Wu S. (2007) Recent advances of mek
inhibitors and their clinical progress. Curr. Top. Med. Chem. 7(14): 1364-78.
2698. Wang K, Cheng C, Li L, Liu H, Huang Q, Xia CH, Yao K, Sun P, Horwitz J, Gong
XH. (2007) Gamma d-crystallin - associated protein aggregation and lens fiber cell
denucleation. Invest. Ophthalmol. Vis. Sci. 48(8): 3719-28.
2699. Wang L, Zheng QC, Song ZG, Fang WS, Li YZ, Huang HM. (2007) Association of
(s)-isoserine derivatives and 2,2,4-trimethyl-3-hydroxy-4-cyclohexenecarboxylate.
Chem. Res. Chin. Univ. 23(1): 18-21.
2700. Wang ZQ, Lawson RJ, Buddha MR, Wei CC, Crane BR, Munro AW, Stuehr DJ.
(2007) Bacterial flavodoxins support nitric oxide production by bacillus subtilis nitricoxide
synthase. J. Biol. Chem. 282(4): 2196-202.
2701. Ward A, Reyes CL, Yu J, Roth CB, Chang G. (2007) Flexibility in the abc
transporter msba: Alternating access with a twist. Proc. Natl. Acad. Sci. U. S. A.
104(48): 19005-10.
2702. Weerapana E, Speers AE, Cravatt BF. (2007) Tandem orthogonal proteolysisactivity-based
protein profiling (top-abpp) - a general method for mapping sites of probe
modification in proteomes. Nat. Protoc. 2(6): 1414-25.
2703. Wei J, Pio BA, Cai H, Meduna SP, Sun S, Gu Y, Jiang W, Thurmond RL,
Karlsson L, Edwards JP. (2007) Pyrazole-based cathepsin s inhibitors with improved
cellular potency. Bioorg. Med. Chem. Lett. 17(20): 5525-8.
2704. Wei RR, Al-Bassam J, Harrison SC. (2007) The ndc80/hec1 complex is a contact
point for kinetochore-microtubule attachment. Nat. Struct. Mol. Biol. 14(1): 54-9.
2705. Wei YX, Zhang DZ, He YL, Xu L, Yang Y, Su BL, Liu ZM. (2007) Catalytic
performance of chloromethane transformation for light olefins production over sapo-34
with different si content. Catal. Lett. 114(1-2): 30-5.
2706. Weinstein DS, Liu W, Ngu K, Langevine C, Combs DW, Zhuang S, Chen C,
Madsen CS, Harper TW, Robl JA. (2007) Discovery of selective imidazole-based
inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a
cellular environment. Bioorg. Med. Chem. Lett. 17(18): 5115-20.

2707. Wilcoxen KM, Leman LJ, Weinberger DA, Huang ZZ, Ghadiri MR. (2007)
Biomimetic catalysis of intermodular aminoacyl transfer. J. Am. Chem. Soc. 129(4): 748-
9.
2708. Williams R, Sengerowa B, Osborne S, Syson K, Ault S, Kilgour A, Chapados BR,
Tainer JA, Sayers JR, Grasby JA. (2007) Comparison of the catalytic parameters and
reaction specificities of a phage and an archaeal flap endonuclease. J. Mol. Biol. 371(1):
34-48.
2709. Winssinger N, Barluenga S. (2007) Chemistry and biology of resorcylic acid
lactones. Chem. Commun. (1): 22-36.
2710. Winssinger N, Pianowski Z, Debaene F. (2007) Probing biology with small
molecule microarrays (smm). Top. Curr. Chem. 278: 311-42.
2711. Wise LE, Shelton CC, Cravatt BF, Martin BR, Lichtman AH. (2007) Assessment
of anandamide's pharmacological effects in mice deficient of both fatty acid amide
hydrolase and cannabinoid cb1 receptors. Eur. J. Pharmacol. 557(1): 44-8.
2712. Wiseman RL, Koulov A, Powers E, Kelly JW, Balch WE. (2007) Protein
energetics in maturation of the early secretory pathway. Curr. Opin. Cell Biol. 19(4):
359-67.
2713. Wiseman RL, Powers ET, Buxbaum JN, Kelly JW, Balch WE. (2007) An
adaptable standard for protein export from the endoplasmic reticulum. Cell. 131(4): 809-
21.
2714. Witus LS, Rocha JDR, Yuwono VM, Paramonov SE, Weisman RB, Hartgerink
JD. (2007) Peptides that non-covalently functionalize single-walled carbon nanotubes to
give controlled solubility characteristics. J. Mater. Chem. 17(19): 1909-15.
2715. Worthington AS, Burkart MD. (2007) The old is new again: Asparagine oxidation
in calcium-dependent antibiotic biosynthesis. ACS Chem. Biol. 2(3): 152-4.
2716. Wright AT, Cravatt BF. (2007) Chemical proteomic probes for profiling
cytochrome p450 activities and drug interactions in vivo. Chem. Biol. 14(9): 1043-51.
2717. Wu P, Fokin VV. (2007) Catalytic azide-alkyne cycloaddition: Reactivity and
applications. Aldrichimica Acta. 40(1): 7-17.
2718. Xie JM, Liu WS, Schultz PG. (2007) A genetically encoded bidentate, metalbinding
amino acid. Angew. Chem.-Int. Edit. 46(48): 9239-42.
2719. Xie JM, Supekova L, Schultz PG. (2007) A genetically encoded metabolically
stable analogue of phosphotyrosine in escherichia coli. ACS Chem. Biol. 2(7): 474-8.
2720. Xie W, Nangle LA, Zhang W, Schimmel P, Yang XL. (2007) Long-range structural
effects of a charcot-marie-tooth disease-causing mutation in human glycyl-trna
synthetase. Proc. Natl. Acad. Sci. U. S. A. 104(24): 9976-81.
2721. Xu Y, Hixon MS, Dawson PE, Janda KD. (2007) Development of a fret assay for
monitoring of hiv gp41 core disruption. J. Org. Chem. 72(18): 6700-7.
2722. Xu Y, Hixon MS, Yamamoto N, McAllister LA, Wentworth AD, Wentworth P,
Janda KD. (2007) Antibody-catalyzed anaerobic destruction of methamphetamine. Proc.
Natl. Acad. Sci. U. S. A. 104(10): 3681-6.
2723. Yachi PP, Lotz C, Ampudia J, Gascoigne NRJ. (2007) T cell activation
enhancement by endogenous pmhc acts for both weak and strong agonists but varies
with differentiation state. J. Exp. Med. 204(11): 2747-57.

2724. Yang JZ, Alemany LB, Driver J, Hartgerink JD, Barron AR. (2007) Fullerenederivatized
amino acids: Synthesis, characterization, antioxidant properties, and solidphase
peptide synthesis. Chem.-Eur. J. 13(9): 2530-45.
2725. Yang YY, Ficht S, Brik A, Wong CH. (2007) Sugar-assisted ligation in
glycoprotein synthesis. J. Am. Chem. Soc. 129(24): 7690-701.
2726. Yao Y, Dickerson TJ, Hixon MS, Dyson HJ. (2007) Nmr detection of adventitious
xylose binding to the quorum-sensing protein sdia of escherichia coli. Bioorg. Med.
Chem. Lett. 17(22): 6202-5.
2727. Yegneswaran S, Tiefenbrunn TK, Fernandez JA, Dawson PE. (2007)
Manipulation of thrombin exosite i, by ligand-directed covalent modification. J. Thromb.
Haemost. 5(10): 2062-9.
2728. Ying Y, Hong J. (2007) Synthesis of brasilibactin a and confirmation of absolute
configuration of beta-hydroxy acid fragment. Tetrahedron Lett. 48(46): 8104-7.
2729. Yoshida W, Yokobayashi Y. (2007) Photonic boolean logic gates based on DNA
aptamers. Chem. Commun. (2): 195-7.
2730. Yu ZQ, Sawkar AR, Kelly JW. (2007) Pharmacologic chaperoning as a strategy
to treat gaucher disease. Febs J. 274(19): 4944-50.
2731. Yu ZQ, Sawkar AR, Whalen LJ, Wong CH, Kelly JW. (2007) Isofagomine- and
2,5-anhydro-2,5-imino-d-glucitol-based glucocerebrosidase pharmacological
chaperones for gaucher disease intervention. J. Med. Chem. 50(1): 94-100.
2732. Yuwono VM, Hartgerink JD. (2007) Peptide amphiphile nanofibers template and
catalyze silica nanotube formation. Langmuir. 23(9): 5033-8.
2733. Zhang MZ, Tamiya J, Nguyen L, Rowbottom MW, Dyck B, Vickers TD, Grey J,
Schwarz DA, Heise CE, Haelewyn J, Mistry MS, Goodfellow VS. (2007)
Thienopyrimidinone bis-aminopyrrolidine ureas as potent melaninconcentrating
hormone receptor-1 (mch-r1) antagonists. Bioorg. Med. Chem. Lett. 17(9): 2535-9.
2734. Zhang QH, Ma XQ, Ward A, Hong WX, Jaakola VP, Stevens RC, Finn MG,
Chang G. (2007) Designing facial amphiphiles for the stabilization of integral membrane
proteins. Angew. Chem.-Int. Edit. 46(37): 7023-5.
2735. Zhang QS, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg
MH, Schultz PG, Moon RT, Ding S. (2007) Small-molecule synergist of the wnt/betacatenin
signaling pathway. Proc. Natl. Acad. Sci. U. S. A. 104(18): 7444-8.
2736. Zhang WJ, Wilke BI, Zhan JX, Watanabe K, Boddy CN, Tang Y. (2007) A new
mechanism for benzopyrone formation in aromatic polyketide biosynthesis. J. Am.
Chem. Soc. 129(30): 9304-+.
2737. Zhang Y, Daum S, Wildemann D, Zhou XZ, Verdecia MA, Bowman ME, Lucke C,
Hunter T, Lu KP, Fischer G, Noel JP. (2007) Structural basis for high-affinity peptide
inhibition of human pin1. ACS Chem. Biol. 2(5): 320-8.
2738. Zhang Y, Kang SA, Mukherjee T, Bale S, Crane BR, Begley TP, Ealick SE.
(2007) Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme
enzyme involved in tryptophan catabolism and in quinolinate biosynthesis(,).
Biochemistry. 46(1): 145-55.
2739. Zhao YX, Ding S. (2007) A high-throughput sirna library screen identifies
osteogenic suppressors in human mesenchyrnal stem cells. Proc. Natl. Acad. Sci. U. S.

A. 104(23): 9673-8.
2740. Zhou DH, Hatzenbuhler NT, Gross JL, Harrison BL, Evrard DA, Chlenov M,
Golembieski J, Hornby G, Schechter LE, Smith DL, Andree TH, Stack GP. (2007) Novel
pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and
5-ht1a receptor. Bioorg. Med. Chem. Lett. 17(11): 3117-21.
2741. Zhou J, Thorpe IF, Izvekov S, Voth GA. (2007) Coarse-grained peptide modeling
using a systematic multiscale approach. Biophys. J. 92(12): 4289-303.
2742. Zoltowski BD, Schwerdtfeger C, Widom J, Loros JJ, Bilwes AM, Dunlap JC,
Crane BR. (2007) Conformational switching in the fungal light sensor vivid. Science.
316(5827): 1054-7.
2743. Aguilar E, Dorrell MI, Friedlander D, Jacobson RA, Johnson A, Marchetti V,
Moreno SK, Ritter MR, Friedlander M. (2008) Ocular models of angiogenesis. Methods
Enzymol. 444: 115-58.
2744. Ahn K, McKinney MK, Cravatt BF. (2008) Enzymatic pathways that regulate
endocannabinoid signaling in the nervous system. Chem. Rev. 108(5): 1687-707.
2745. Alexandrov AI, Mileni M, Chien EYT, Hanson MA, Stevens RC. (2008)
Microscale fluorescent thermal stability assay for membrane proteins. Structure. 16(3):
351-9.
2746. Alfaro JF, Gillies LA, Sun HG, Dai SJ, Zang TZ, Klaene JJ, Kim BJ, Lowenson
JD, Clarke SG, Karger BL, Zhou ZS. (2008) Chemo-enzymatic detection of protein
isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping. Anal.
Chem. 80(10): 3882-9.
2747. Aliahmad P, Kaye J. (2008) Development of all cd4 t lineages requires nuclear
factor tox. J. Exp. Med. 205(1): 245-56.
2748. Alper PB, Marsilje TH, Mutnick D, Lu WS, Chatterjee A, Roberts MJ, He Y,
Karanewsky DS, Chow D, Lao JM, Gerken A, Tuntland T, Liu B, Chang J, Gordon P,
Seidel HM, Tian SS. (2008) Discovery and biological evaluation of benzo[a] carbazolebased
small molecule agonists of the thrombopoietin (tpo) receptor. Bioorg. Med. Chem.
Lett. 18(19): 5255-8.
2749. Arnold LA, Ranaivo P, Guy RK. (2008) Synthesis and characterization of bodipylabeled
colchicine. Bioorg. Med. Chem. Lett. 18(22): 5867-70.
2750. Asmar-Rovira GA, Asseo-Garcia AM, Quesada O, Hanson MA, Cheng A,
Nogueras C, Lasalde-Dominicci JA, Stevens RC. (2008) Biophysical and ion channel
functional characterization of the torpedo californica nicotinic acetylcholine receptor in
varying detergent-lipid environments. J. Membr. Biol. 223(1): 13-26.
2751. Astronomo RD, Lee HK, Scanlan CN, Pantophlet R, Huang CY, Wilson IA, Blixt
O, Dwek RA, Wong CH, Burton DR. (2008) A glycoconjugate antigen based on the
recognition motif of a broadly neutralizing human immunodeficiency virus antibody,
2g12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.
J. Virol. 82(13): 6359-68.
2752. Bai R, Vanderwal CD, Diaz JF, Hamel E. (2008) Interaction of a cyclostreptin
analogue with the microtubule taxoid site: The covalent reaction rapidly follows binding.
J. Nat. Prod. 71(3): 370-4.
2753. Banerjee B, Capps SG, Kang J, Robinson JW, Castle SL. (2008) Second-

generation dbfox ligands for the synthesis of beta-substituted alpha-amino acids via
enantioselective radical conjugate additions. J. Org. Chem. 73(22): 8973-8.
2754. Barglow KT, Saikatendu KS, Bracey MH, Huey R, Morris GM, Olson AJ, Stevens
RC, Cravatt BF. (2008) Functional proteomic and structural insights into molecular
recognition in the nitrilase family enzymes. Biochemistry. 47(51): 13514-23.
2755. Barluenga S, Dakas PY, Boulifa M, Moulin E, Winssinger N. (2008) Resorcylic
acid lactones: A pluripotent scaffold with therapeutic potential. C. R. Chim. 11(11-12):
1306-17.
2756. Barluenga S, Wang CH, Fontaine JG, Aouadi K, Beebe K, Tsutsumi S, Neckers
L, Winssinger N. (2008) Divergent synthesis of a pochonin library targeting hsp90 and in
vivo efficacy of an identified inhibitor. Angew. Chem.-Int. Edit. 47(23): 4432-5.
2757. Barnes D, Kunitomi M, Vignuzzi M, Saksela K, Andino R. (2008) Harnessing
endogenous mirnas to control virus tissue tropism as a strategy for developing
attenuated virus vaccines. Cell Host Microbe. 4(3): 239-48.
2758. Barrett ES, Dale TJ, Rebek J. (2008) Stability, dynamics, and selectivity in the
assembly of hydrogen-bonded hexameric capsules. J. Am. Chem. Soc. 130(7): 2344-
50.
2759. Baxter I, Muthukumar B, Park HC, Buchner P, Lahner B, Danku J, Zhao K, Lee J,
Hawkesford MJ, Guerinot ML, Salt DE. (2008) Variation in molybdenum content across
broadly distributed populations of arabidopsis thaliana is controlled by a mitochondrial
molybdenum transporter (mot1). PLoS Genet. 4(2): 12.
2760. Baxter IR, Vitek O, Lahner B, Muthukumar B, Borghi M, Morrissey J, Guerinot
ML, Salt DE. (2008) The leaf ionome as a multivariable system to detect a plant's
physiological status. Proc. Natl. Acad. Sci. U. S. A. 105(33): 12081-6.
2761. Bergman JM, Roecker AJ, Mercer SP, Bednar RA, Reiss DR, Ransom RW,
Harrell CM, Pettibone DJ, Lemaire W, Murphy KL, Li C, Prueksaritanont T, Winrow CJ,
Renger JJ, Koblan KS, Hartman GD, Coleman PJ. (2008) Proline bis-amides as potent
dual orexin receptor antagonists. Bioorg. Med. Chem. Lett. 18(4): 1425-30.
2762. Bernal F, Raman JD. (2008) Exploration of treatment options for the
management of stage i testicular seminoma. Expert Rev. Anticancer Ther. 8(7): 1081-
90.
2763. Bird GH, Bernal F, Pitter K, Walensky LD. (2008) Synthesis and biophysical
characterization of stabilized alpha-helices of bcl-2 domains. Methods Enzymol. 446:
369-86.
2764. Biros SM, Yeh RM, Raymond KN. (2008) Design and formation of a large
tetrahedral cluster using 1,1 '-binaphthyl ligands. Angew. Chem.-Int. Edit. 47(32): 6062-
4.
2765. Blackler AR, Speers AE, Ladinsky MS, Wu CC. (2008) A shotgun proteomic
method for the identification of membrane-embedded proteins and peptides. J.
Proteome Res. 7(7): 3028-34.
2766. Blackler AR, Speers AE, Wu CC. (2008) Chromatographic benefits of elevated
temperature for the proteomic analysis of membrane proteins. Proteomics. 8(19): 3956-
64.
2767. Blanco-Canosa JB, Dawson PE. (2008) An efficient fmoc-spps approach for the

generation of thioester peptide precursors for use in native chemical ligation. Angew.
Chem.-Int. Edit. 47(36): 6851-5.
2768. Breitling R, Li Y, Tesson BM, Fu JY, Wu CL, Wiltshire T, Gerrits A, Bystrykh LV,
de Haan G, Su AI, Jansen RC. (2008) Genetical genomics: Spotlight on qtl hotspots.
PLoS Genet. 4(10): 4.
2769. Brouhard GJ, Stear JH, Noetzel TL, Al-Bassam J, Kinoshita K, Harrison SC,
Howard J, Hyman AA. (2008) Xmap215 is a processive microtubule polymerase. Cell.
132(1): 79-88.
2770. Bull SR, Palmer LC, Fry NJ, Greenfield MA, Messmore BW, Meade TJ, Stupp SI.
(2008) A templating approach for monodisperse self-assembled organic nanostructures.
J. Am. Chem. Soc. 130(9): 2742-+.
2771. Burkart MD, Greenberg WA. (2008) In honor of professor chi-huey wong on the
occasion of his 60(th) birthday. Adv. Synth. Catal. 350(11-12): 1659-60.
2772. Burlina F, Dixson DD, Doyle RP, Chassaing G, Boddy CN, Dawson P, Offer J.
(2008) Orthogonal ligation: A three piece assembly of a pna-peptide-pna conjugate.
Chem. Commun. (24): 2785-7.
2773. Burns NZ, Baran PS. (2008) On the origin of the haouamine alkaloids. Angew.
Chem.-Int. Edit. 47(1): 205-8.
2774. Byun JH, Kim H, Kim Y, Mook-Jung I, Kim DJ, Lee WK, Yoo KH. (2008)
Aminostyrylbenzofuran derivatives as potent inhibitors for a beta fibril formation. Bioorg.
Med. Chem. Lett. 18(20): 5591-3.
2775. Carter AP, Garbarino JE, Wilson-Kubalek EM, Shipley WE, Cho C, Milligan RA,
Vale RD, Gibbons IR. (2008) Structure and functional role of dynein's microtubulebinding
domain. Science. 322(5908): 1691-5.
2776. Chao JA, Patskovsky Y, Almo SC, Singer RH. (2008) Structural basis for the
coevolution of a viral rna-protein complex. Nat. Struct. Mol. Biol. 15(1): 103-5.
2777. Chen C, Dyck B, Fleck BA, Foster AC, Grey J, Jovic F, Mesleh M, Phan K,
Tamiya J, Vickers T, Zhang MZ. (2008) Studies on the sar and pharmacophore of
milnacipran derivatives as monoamine transporter inhibitors. Bioorg. Med. Chem. Lett.
18(4): 1346-9.
2778. Chen H, Gu W, Cellar N, Kennedy R, Takayama S, Meiners JC. (2008)
Electromechanical properties of pressure-actuated poly(dimethylsiloxane) microfluidic
push-down valves. Anal. Chem. 80(15): 6110-3.
2779. Chen JR, Chang BH, Allen JE, Stiffler MA, MacBeath G. (2008) Predicting pdz
domain-peptide interactions from primary sequences. Nat. Biotechnol. 26(9): 1041-5.
2780. Chen K, Richter JM, Baran PS. (2008) 1,3-diol synthesis via controlled, radicalmediated
c-h functionalization. J. Am. Chem. Soc. 130(23): 7247-+.
2781. Chen ML, Adak AK, Yeh NC, Yang WB, Chuang YJ, Wong CH, Hwang KC, Hwu
JRR, Hsieh SL, Lin CC. (2008) Fabrication of an oriented fc-fused lectin microarray
through boronate formation. Angew. Chem.-Int. Edit. 47(45): 8627-30.
2782. Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR. (2008) Synthesis of
macrocyclic trypanosomal cysteine protease inhibitors. Bioorg. Med. Chem. Lett. 18(22):
5860-3.
2783. Cherezov V, Liu J, Griffith M, Hanson MA, Stevens RC. (2008) Lcp-frap assay for

pre-screening membrane proteins for in meso crystallization. Cryst. Growth Des. 8(12):
4307-15.
2784. Chua C, Zaiden N, Chong KH, See SJ, Wong MC, Ang BT, Tang C. (2008)
Characterization of a side population of astrocytoma cells in response to temozolomide.
J. Neurosurg. 109(5): 856-66.
2785. Clark DA, Lahm GP, Smith BK, Barry JD, Clagg DG. (2008) Synthesis of
insecticidal fluorinated anthranilic diamides. Bioorg. Med. Chem. 16(6): 3163-70.
2786. Clark RC, Lee SY, Boger DL. (2008) Total synthesis of chlorofusin, its seven
chromophore diastereomers, and key partial structures. J. Am. Chem. Soc. 130(37):
12355-69.
2787. Conn EM, Madsen MA, Cravatt BF, Ruf W, Deryugina EI, Quigley JP. (2008) Cell
surface proteomics identifies molecules functionally linked to tumor cell intravasation. J.
Biol. Chem. 283(39): 26518-27.
2788. Coureux PD, Fan ZP, Stojanoff V, Genick UK. (2008) Picometer-scale
conformational heterogeneity separates functional from nonfunctional states of a
photoreceptor protein. Structure. 16(6): 863-72.
2789. Cox CD, Coleman PJ, Breslin MJ, Whitman DB, Garbaccio RM, Fraley ME,
Buser CA, Walsh ES, Hamilton K, Schaber MD, Lobell RB, Tao W, Davide JP, Diehl RE,
Abrams MT, South VJ, Huber HE, Torrent M, Prueksaritanont T, Li C, Slaughter DE,
Mahan E, Fernandez-Metzler C, Yan Y, Kuo LC, Kohl NE, Hartman GD. (2008) Kinesin
spindle protein (ksp) inhibitors. 9. Discovery of (2s)-4-(2,5-difluorophenyl)-n-[(3r,4s)-3fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-n-methyl-2-phenyl-2,5-dihydro-1hpyrrole-1-carboxamide
(mk-0731) for the treatment of taxane-refractory cancer. J. Med.
Chem. 51(14): 4239-52.
2790. Cravatt BF. (2008) Tetrahedron young investigator award 2008 introduction.
Bioorg. Med. Chem. Lett. 18(22): 5837-.
2791. Cravatt BF, Wright AT, Kozarich JW. (2008) Activity-based protein profiling: From
enzyme chemistry. Annu. Rev. Biochem. 77: 383-414.
2792. Davis N, Biddlecom N, Hecht D, Fogel GB. (2008) On the relationship between
gc content and the number of predicted microrna binding sites by microinspector.
Comput. Biol. Chem. 32(3): 222-6.
2793. Debler EW, Kaufmann GF, Meijler MM, Heine A, Mee JM, Pljevaljcic G, Di Bilio
AJ, Schultz PG, Millar DP, Janda KD, Wilson IA, Gray HB, Lerner RA. (2008) Deeply
inverted electron-hole recombination in a luminescent antibody-stilbene complex.
Science. 319(5867): 1232-5.
2794. Debler EW, Muller R, Hilvert D, Wilson IA. (2008) Conformational isomerism can
limit antibody catalysis. J. Biol. Chem. 283(24): 16554-60.
2795. DeMartino JK, Garfunkle J, Hochstatter DG, Cravatt BF, Boger DL. (2008)
Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme
inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase. Bioorg. Med.
Chem. Lett. 18(22): 5842-6.
2796. DeMartino JK, Hwang I, Connelly S, Wilson IA, Boger DL. (2008) Asymmetric
synthesis of inhibitors of glycinamide ribonucleotide transformylase. J. Med. Chem.
51(17): 5441-8.

2797. DeMartino MP, Chen K, Baran PS. (2008) Intermolecular enolate heterocoupling:
Scope, mechanism, and application. J. Am. Chem. Soc. 130(34): 11546-60.
2798. Dhillon AK, Stanfield RL, Gorny MK, Williams C, Zolla-Pazner S, Wilson IA.
(2008) Structure determination of an anti-hiv-1 fab 447-52d-peptide complex from an
epitaxially twinned data set. Acta Crystallogr. Sect. D-Biol. Crystallogr. 64: 792-802.
2799. Dillon TM, Ricci MS, Vezina C, Flynn GC, Liu YD, Rehder DS, Plant M, Henkle B,
Li Y, Deechongkit S, Varnum B, Wypych J, Balland A, Bondarenko PV. (2008)
Structural and functional characterization of disulfide isoforms of the human igg2
subclass. J. Biol. Chem. 283(23): 16206-15.
2800. Ding Y, Seufert WH, Beck ZQ, Sherman DH. (2008) Analysis of the cryptophycin
p450 epoxidase reveals substrate tolerance and cooperativity. J. Am. Chem. Soc.
130(16): 5492-8.
2801. Dix MM, Simon GM, Cravatt BF. (2008) Global mapping of the topography and
magnitude of proteolytic events in apoptosis. Cell. 134(4): 679-91.
2802. Do T, Ho F, Heidecker B, Witte K, Chang L, Lerner L. (2008) A rapid method for
determining dynamic binding capacity of resins for the purification of proteins. Protein
Expr. Purif. 60(2): 147-50.
2803. Dominy BN. (2008) Molecular recognition and binding free energy calculations in
drug development. Curr. Pharm. Biotechnol. 9(2): 87-95.
2804. Dong H, Paramonov SE, Hartgerink JD. (2008) Self-assembly of alpha-helical
coiled coil nanofibers. J. Am. Chem. Soc. 130(41): 13691-5.
2805. Dorn JF, Danuser G, Yang G. (2008) Computational processing and analysis of
dynamic fluorescence image data. Methods Cell Biol. 85: 497-+.
2806. Dorn JF, Maddox PS. (2008) Chromosome segregation: Centromeres get bent.
Curr. Biol. 18(4): R159-R61.
2807. Douty B, Wayland B, Ala PJ, Bower MJ, Pruitt J, Bostrom L, Wei M, Klabe R,
Gonneville L, Wynn R, Burn TC, Liu PCC, Combs AP, Yue EW. (2008) Isothiazolidinone
inhibitors of ptp1b containing imidazoles and imidazolines. Bioorg. Med. Chem. Lett.
18(1): 66-71.
2808. Douville N, Huh D, Takayama S. (2008) DNA linearization through confinement in
nanofluidic channels. Anal. Bioanal. Chem. 391(7): 2395-409.
2809. Dyck B, Tamiya J, Jovic F, Pick RR, Bradbury MJ, O'Brien J, Wen J, Johns M,
Madan A, Fleck BA, Foster AC, Li B, Zhang M, Tran JA, Vickers T, Grey J, Saunders J,
Chen C. (2008) Characterization of thien-2-yl 1s,2r-milnacipran analogues as potent
norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain. J.
Med. Chem. 51(22): 7265-72.
2810. Egertova M, Simon GM, Cravatt BF, Elphick MR. (2008) Localization of n-acyl
phosphatidylethanolamine phospholipase d (nape-pld) expression in mouse brain: A
new perspective on n-acylethanolamines as neural signaling molecules. J. Comp.
Neurol. 506(4): 604-15.
2811. Elworthy TR, Dunn JP, Hogg JH, Lam G, Saito YD, Silva T, Stefanidis D,
Woroniecki W, Zhornisky E, Zhou AS, Klumpp K. (2008) Orally bioavailable prodrugs of
a bcs class 2 molecule, an inhibitor of hiv-1 reverse transcriptase. Bioorg. Med. Chem.
Lett. 18(24): 6344-7.

2812. Emond MR, Jontes JD. (2008) Inhibition of protocadherin-alpha function results
in neuronal death in the developing zebrafish. Dev. Biol. 321(1): 175-87.
2813. Fan CY, Tung YC, Takayama S, Meyhofer E, Kurabayashi K. (2008) Electrically
programmable surfaces for configurable patterning of cells. Adv. Mater. 20(8): 1418-+.
2814. Fang QM, Noronha AM, Murphy SP, Wilds CJ, Tubbs JL, Tainer JA, Chowdhury
G, Guengerich FP, Pegg AE. (2008) Repair of o-6-g-alkyl-o-6-g interstrand cross-links
by human o-6-alkylguanine-DNA alkyltransferase. Biochemistry. 47(41): 10892-903.
2815. Fei ZB, Wu QB, Zhang F, Cao YD, Liu CQ, Shieh WC, Xue S, McKenna J,
Prasad K, Prashad M, Baeschlin D, Namoto K. (2008) A scalable synthesis of an
azabicyclooctanyl derivative, a novel dpp-4 inhibitor. J. Org. Chem. 73(22): 9016-21.
2816. Fischer NO, Tarasow TM, Tok JBH. (2008) Protein detection via direct enzymatic
amplification of short DNA aptamers. Anal. Biochem. 373(1): 121-8.
2817. Fish PV, Barta NS, Gray DLF, Ryckmans T, Stobie A, Wakenhut F, Whitlock GA.
(2008) Derivatives of (3s)-n-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective
noradrenaline reuptake inhibitors: Reducing p-gp mediated efflux by modulation of hbond
acceptor capacity. Bioorg. Med. Chem. Lett. 18(15): 4355-9.
2818. Fogel GB, Cheung M, Pittman E, Hecht D. (2008) Modeling the inhibition of
quadruple mutant plasmodium falciparum dihydrofolate reductase by pyrimethamine
derivatives. J. Comput.-Aided Mol. Des. 22(1): 29-38.
2819. Fogel GB, Cheung M, Pittman E, Hecht D. (2008) In silico screening against wildtype
and mutant plasmodium falciparum dihydrofolate reductase. J. Mol. Graph. 26(7):
1145-52.
2820. Fox DT, Hotta K, Kim CY, Koppisch AT. (2008) The missing link in petrobactin
biosynthesis: Asbf encodes a (-)-3-dehydroshikimate dehydratase. Biochemistry.
47(47): 12251-3.
2821. Frueh DP, Arthanari H, Koglin A, Vosburg DA, Bennett AE, Walsh CT, Wagner
G. (2008) Dynamic thiolation-thioesterase structure of a non-ribosomal peptide
synthetase. Nature. 454(7206): 903-U62.
2822. Fucini RV, Hanan EJ, Romanowski MJ, Elling RA, Lew W, Barr KJ, Zhu J,
Yoburn JC, Liu Y, Fahr BT, Fan JF, Lu Y, Pham P, Choong IC, VanderPorten EC, Bui
M, Purkey HE, Evanchik MJ, Yang WJ. (2008) Design and synthesis of 2-aminopyrazolopyridines
as polo-like kinase 1 inhibitors. Bioorg. Med. Chem. Lett. 18(20):
5648-52.
2823. Fujioka H, Takayama S, Grotberg JB. (2008) Unsteady propagation of a liquid
plug in a liquid-lined straight tube. Phys. Fluids. 20(6): 13.
2824. Galler KM, Cavender A, Yuwono V, Dong H, Shi ST, Schmalz G, Hartgerink JD,
D'Souza RN. (2008) Self-assembling peptide amphiphile nanofibers as a scaffold for
dental stem cells. Tissue Eng. Part A. 14(12): 2051-8.
2825. Gan L, Chen SY, Jensen GJ. (2008) Molecular organization of gram-negative
peptidoglycan. Proc. Natl. Acad. Sci. U. S. A. 105(48): 18953-7.
2826. Gan L, Johnson JE. (2008) An optimal exposure strategy for cryoprotected virus
crystals with lattice constants greater than 1000 angstrom. J. Synchrot. Radiat. 15: 223-
6.
2827. Garcia-Cuadrado D, Barluenga S, Winssinger N. (2008) Diversity-oriented

synthesis of novel polycyclic scaffolds using polymer-bound reagents. Chem. Commun.
(38): 4619-21.
2828. Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G,
Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC,
Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV,
Tainer JA, Getzoff ED. (2008) Anchored plasticity opens doors for selective inhibitor
design in nitric oxide synthase. Nat. Chem. Biol. 4(11): 700-7.
2829. Garcin ED, Hosfield DJ, Desai SA, Haas BJ, Bjoras M, Cunningham RP, Tainer
JA. (2008) DNA apurinic-apyrimidinic site binding and excision by endonuclease iv. Nat.
Struct. Mol. Biol. 15(5): 515-22.
2830. Gaskill PJ, Zandonatti M, Gilmartin T, Head SR, Fox HS. (2008) Macrophagederived
simian immunodeficiency virus exhibits enhanced infectivity by comparison with
t-cell-derived virus. J. Virol. 82(3): 1615-21.
2831. Gauba V, Hartgerink JD. (2008) Synthetic collagen heterotrimers: Structural
mimics of wild-type and mutant collagen type i. J. Am. Chem. Soc. 130(23): 7509-15.
2832. Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S,
Campana WM, Cravatt BF, Gonias SL. (2008) Regulation of tumor necrosis factor
receptor-1 and the ikk-nf-kappa b pathway by ldl receptor-related protein explains the
antiinflammatory activity of this receptor. Blood. 111(11): 5316-25.
2833. Gillet LCJ, Namoto K, Ruchti A, Hoving S, Boesch D, Inverardi B, Mueller D,
Coulot M, Schindler P, Schweigler P, Bernardi A, Gil-Parrado S. (2008) In-cell selectivity
profiling of serine protease inhibitors by activity-based proteomics. Mol. Cell.
Proteomics. 7(7): 1241-53.
2834. Gong Y, Ma M, Luo Y, Bong D. (2008) Functional determinants of a synthetic
vesicle fusion system. J. Am. Chem. Soc. 130(19): 6196-205.
2835. Gough MJ, Ruby CE, Redmond WL, Dhungel B, Brown A, Weinberg AD. (2008)
Ox40 agonist therapy enhances cd8 infiltration and decreases immune suppression in
the tumor. Cancer Res. 68(13): 5206-15.
2836. Graziano JJ, Liu WS, Perera R, Geierstanger BH, Lesley SA, Schultz PG. (2008)
Selecting folded proteins from a library of secondary structural elements. J. Am. Chem.
Soc. 130(1): 176-85.
2837. Guo JT, Wang JY, Anderson JC, Schultz PG. (2008) Addition of an alphahydroxy
acid to the genetic code of bacteria. Angew. Chem.-Int. Edit. 47(4): 722-5.
2838. Guo X, Bandyopadhyay P, Schilling B, Young MM, Fujii N, Aynechi T, Guy RK,
Kuntz ID, Gibson BW. (2008) Partial acetylation of lysine residues improves intraprotein
cross-linking. Anal. Chem. 80(4): 951-60.
2839. Guvench O, Greene SN, Kamath G, Brady JW, Venable RM, Pastor RW,
Mackerell AD. (2008) Additive empirical force field for hexopyranose monosaccharides.
J. Comput. Chem. 29(15): 2543-64.
2840. Guvench O, MacKerell AD. (2008) Automated conformational energy fitting for
force-field development. J. Mol. Model. 14(8): 667-79.
2841. Hadnagy A, Beaulieu R, Balicki D. (2008) Histone tail modifications and
noncanonical functions of histones: Perspectives in cancer epigenetics. Mol. Cancer
Ther. 7(4): 740-8.

2842. Halpern D, Fujioka H, Takayama S, Grotberg JB. (2008) Liquid and surfactant
delivery into pulmonary airways. Respir. Physiol. Neuro. 163(1-3): 222-31.
2843. Hanan EJ, Fucini RV, Romanowski MJ, Elling RA, Lew W, Purkey HE,
VanderPorten EC, Yang WJ. (2008) Design and synthesis of 2-aminoisoxazolopyridines
as polo-like kinase inhibitors. Bioorg. Med. Chem. Lett. 18(19): 5186-
9.
2844. Hanson MA, Cherezov V, Griffith MT, Roth CB, Jaakola VP, Chien EYT,
Velasquez J, Kuhn P, Stevens RC. (2008) A specific cholesterol binding site is
established by the 2.8 angstrom structure of the human beta(2)-adrenergic receptor.
Structure. 16(6): 897-905.
2845. Harikrishnan LS, Kamau MG, Herpin TF, Morton GC, Liu Y, Cooper CB, Salvati
ME, Qiao JX, Wang TC, Adam LP, Taylor DS, Chen AYA, Yin X, Seethala R, Peterson
TL, Nirschl DS, Miller AV, Weigelt CA, Appiah KK, O'Connell JC, Lawrence RM. (2008)
2-arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: Optimization
via array synthesis. Bioorg. Med. Chem. Lett. 18(8): 2640-4.
2846. Hastings CJ, Pluth MD, Biros SM, Bergman RG, Raymond KN. (2008)
Simultaneously bound guests and chiral recognition: A chiral self-assembled
supramolecular host encapsulates hydrophobic guests. Tetrahedron. 64(36): 8362-7.
2847. Hecht D, Cheung M, Fogel GB. (2008) Qsar using evolved neural networks for
the inhibition of mutant pfdhfr by pyrimethamine derivatives. Biosystems. 92(1): 10-5.
2848. Hegde VL, Hegde S, Cravatt BF, Hofseth LJ, Nagarkatti M, Nagarkatti PS. (2008)
Attenuation of experimental autoimmune hepatitis by exogenous and endogenous
cannabinoids: Involvement of regulatory t cells. Mol. Pharmacol. 74(1): 20-33.
2849. Hills RD, Brooks CL. (2008) Coevolution of function and the folding landscape:
Correlation with density of native contacts. Biophys. J. 95(9): L57-L9.
2850. Hills RD, Brooks CL. (2008) Subdomain competition, cooperativity, and
topological frustration in the folding of chey. J. Mol. Biol. 382(2): 485-95.
2851. Hogenesch JB, Su AI. (2008) Clock gene wikis available: Join the "'long tail". J.
Biol. Rhythms. 23(5): 456-7.
2852. Hook V, Funkelstein L, Lu D, Bark S, Wegrzyn J, Hwang SR. (2008) Proteases
for processing proneuropeptides into peptide neurotransmitters and hormones. Annu.
Rev. Pharmacol. Toxicol. 48: 393-423.
2853. Hoover HS, Blankman JL, Niessen S, Cravatt BF. (2008) Selectivity of inhibitors
of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorg.
Med. Chem. Lett. 18(22): 5838-41.
2854. Horne WS, Boersma MD, Windsor MA, Gellman SH. (2008) Sequence-based
design of alpha/beta-peptide foldamers that mimic bh3 domains. Angew. Chem.-Int.
Edit. 47(15): 2853-6.
2855. Horne WS, Gellman SH. (2008) Foldamers with heterogeneous backbones.
Accounts Chem. Res. 41(10): 1399-408.
2856. Horne WS, Price JL, Gellman SH. (2008) Interplay among side chain sequence,
backbone composition, and residue rigidification in polypeptide folding and assembly.
Proc. Natl. Acad. Sci. U. S. A. 105(27): 9151-6.
2857. Huang HM, Li L, Wu CG, Schibli D, Colwill K, Ma SC, Li CJ, Roy P, Ho K, Zhou

SY, Pawson T, Gao YH, Li SSC. (2008) Defining the specificity space of the human src
homology 2 domain. Mol. Cell. Proteomics. 7(4): 768-84.
2858. Huang JF, Thurmond RL. (2008) The new biology of histamine receptors. Curr.
Allergy Asthma Rep. 8(1): 21-7.
2859. Huang ZZ, Leman LJ, Ghadiri MR. (2008) Biomimetic catalysis of
diketopiperazine and dipeptide syntheses. Angew. Chem.-Int. Edit. 47(9): 1758-61.
2860. Huh CW, Roush WR. (2008) Highly stereoselective and modular syntheses of
10-hydroxytrilobacin and three diastereomers via stereodivergent [3+2]-annulation
reactions. Org. Lett. 10(15): 3371-4.
2861. Huss JW, Orozco C, Goodale J, Wu CL, Batalov S, Vickers TJ, Valafar F, Su AI.
(2008) A gene wiki for community annotation of gene function. PLoS. Biol. 6(7): 1398-
402.
2862. Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EYT, Lane JR, Ijzerman
AP, Stevens RC. (2008) The 2.6 angstrom crystal structure of a human a(2a) adenosine
receptor bound to an antagonist. Science. 322(5905): 1211-7.
2863. Jackson D, Gooya J, Mao SL, Kinneer K, Xu LD, Camara M, Fazenbaker C,
Fleming R, Swamynathan S, Meyer D, Senter PD, Gao C, Wu HR, Kinch M, Coats S,
Kiener PA, Tice DA. (2008) A human antibody-drug conjugate targeting epha2 inhibits
tumor growth in vivo. Cancer Res. 68(22): 9367-74.
2864. Jager M, Deechongkit S, Koepf EK, Nguyen H, Gao JM, Powers ET, Gruebele M,
Kelly JW. (2008) Understanding the mechanism of beta-sheet folding from a chemical
and biological perspective. Biopolymers. 90(6): 751-8.
2865. Johansson M, Purse BW, Terasaki O, Backvall JE. (2008) Aerobic oxidations
catalyzed by zeolite-encapsulated cobalt salophen. Adv. Synth. Catal. 350(11-12):
1807-15.
2866. Johnson EG, Sparks JP, Dzikovski B, Crane BR, Gibson DM, Loria R. (2008)
Plant-pathogenic streptomyces species produce nitric oxide synthase-derived nitric
oxide in response to host signals. Chem. Biol. 15(1): 43-50.
2867. Johnson SM, Connelly S, Wilson IA, Kelly JW. (2008) Toward optimization of the
linker substructure common to transthyretin amyloidogenesis inhibitors using
biochemical and structural studies. J. Med. Chem. 51(20): 6348-58.
2868. Johnson SM, Connelly S, Wilson IA, Kelly JW. (2008) Biochemical and structural
evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis
inhibitors. J. Med. Chem. 51(2): 260-70.
2869. Jun HW, Paramonov SE, Dong H, Forraz N, McGuckin C, Hartgerink JD. (2008)
Tuning the mechanical and bioresponsive properties of peptide-amphiphile nanofiber
networks. J. Biomater. Sci.-Polym. Ed. 19(5): 665-76.
2870. Kabir M, Sudhamsu J, Crane BR, Yeh SR, Rousseau DL. (2008) Substrateligand
interactions in geobacillus stearothermophilus nitric oxide synthase.
Biochemistry. 47(47): 12389-97.
2871. Kagan M, Chlenov M, Melnikov S, Greenfield A, Gross J, Bernotas RC. (2008)
Optimization of normal-phase chromatographic separation of compounds with primary,
secondary and tertiary amino groups. J. Chromatogr. A. 1194(1): 80-9.
2872. Kairouz-Wahbe R, Biliran H, Luo X, Khor I, Wankell M, Besch-Williford C,

Pascual J, Oshima R, Ruoslahti E. (2008) Anoikis effector bit1 negatively regulates erk
activity. Proc. Natl. Acad. Sci. U. S. A. 105(5): 1528-32.
2873. Kaltgrad E, O'Reilly MK, Liao LA, Han SF, Paulson JC, Finn MG. (2008) On-virus
construction of polyvalent glycan ligands for cell-surface receptors. J. Am. Chem. Soc.
130(14): 4578-+.
2874. Kamath G, Guvench O, MacKerell AD. (2008) Charmm additive all-atom force
field for acyclic carbohydrates and inositol. J. Chem. Theory Comput. 4(5): 765-78.
2875. Kamotani Y, Bersano-Begey T, Kato N, Tung YC, Huh D, Song JW, Takayama
S. (2008) Individually programmable cell stretching microwell arrays actuated by a
braille display. Biomaterials. 29(17): 2646-55.
2876. Kang CB, Tian CL, Sonnichsen FD, Smith JA, Meiler J, George AL, Vanoye CG,
Kim HJ, Sanders CR. (2008) Structure of kcne1 and implications for how it modulates
the kcnq1 potassium channel. Biochemistry. 47(31): 7999-8006.
2877. Kaufmann GF, Park J, Janda KD. (2008) Bacterial quorum sensing: A new target
for anti-infective immunotherapy. Expert Opin. Biol. Ther. 8(6): 719-24.
2878. Kaufmann GF, Park J, Mee JM, Ulevitch RJ, Janda KD. (2008) The quorum
quenching antibody rs2-1g9 protects macrophages from the cytotoxic effects of the
pseudomonas aeruginosa quorum sensing signalling molecule n-3-oxo-dodecanoylhomoserine
lactone. Mol. Immunol. 45(9): 2710-4.
2879. Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G. (2008)
System-wide investigation of erbb4 reveals 19 sites of tyr phosphorylation that are
unusually selective in their recruitment properties. Chem. Biol. 15(8): 808-17.
2880. Kaushansky A, Gordus A, Chang B, Rush J, MacBeath G. (2008) A quantitative
study of the recruitment potential of all intracellular tyrosine residues on egfr, fgfr1 and
igf1r. Mol. Biosyst. 4(6): 643-53.
2881. Kinjo Y, Pei B, Bufali S, Raju R, Richardson SK, Imamura M, Fujio M, Wu D,
Khurana A, Kawahara K, Wong CH, Howell AR, Seeberger PH, Kronenberg M. (2008)
Natural sphingomonas glycolipids vary greatly in their ability to activate natural killer t
cells. Chem. Biol. 15(7): 654-64.
2882. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M,
Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi XN,
Biard-Piechaczyk M, Blum JS, Breclesen DE, Brodsky JL, Brumell JH, Brunk UT,
Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen YY, Chin LS, Choi A, Chu CT,
Chung JK, Clarke PGH, Clark RSB, Clarke SG, Clave C, Cleveland JL, Codogno P,
Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis
PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, DiFiglia M, Dinesh-Kumar
S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Droge W, Dron M, Dunn WA,
Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fesues L, Finley KD,
Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A,
Goldberg AL, Gonzalez R, Gonzalez-Estevez C, Gorski S, Gottlieb RA, Haussinger D,
He YW, Heidenreich K, Hill JA, Hoyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jaattela
M, Jackson WT, Jiang X, Jin SK, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar
A, Kessel DH, Kiel J, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E,
Komatsu M, Kominami E, Konclo S, Kovacs AL, Kroemer G, Kuan CY, Kumar R, Kundu

M, Landry J, Laporte M, Le WD, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL,
Lin FC, Liou W, Liu LF, Lopez-Berestein G, Lopez-Otin C, Lu B, Macleod KF, Malorni
W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Melendez A, Michels P, Miotto G,
Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu
Y, Motyl T, Munz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T,
Nurnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE,
Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R,
Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein
DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M,
Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A,
Silva-Zacarin ECM, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K,
Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer
D, Suzuki T, Swanson MS, Takeshita F, Talbot NJ, Talloczy Z, Tanaka K, Tanida I,
Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky
AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcategui NL, van der
Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi ZJ, Xiao G,
Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue ZY, Yuzaki M, Zabirnyk
O, Zheng XX, Zhu X, Deter RL, Tabas I. (2008) Guidelines for the use and interpretation
of assays for monitoring autophagy in higher eukaryotes. Autophagy. 4(2): 151-75.
2883. Ko KS, Najmabadi P, La Clair JJ, Burkart MD. (2008) Affinity analyses on
moldable optical polycarbonate. Chembiochem. 9(2): 201-5.
2884. Koppisch AT, Hotta K, Fox DT, Ruggiero CE, Kim CY, Sanchez T, Iyer S,
Browder CC, Unkefer PJ, Unkefer CJ. (2008) Biosynthesis of the 3,4-dihydroxybenzoate
moieties of petrobactin by bacillus anthracis. J. Org. Chem. 73(15): 5759-65.
2885. Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Grauer DC,
Lehmann M, Meijler MM, Janda KD, Ulevitch RJ. (2008) Modulation of gene expression
via disruption of nf-kappa b signaling by a bacterial small molecule. Science. 321(5886):
259-63.
2886. Lam MT, Clem WC, Takayama S. (2008) Reversible on-demand cell alignment
using reconfigurable microtopography. Biomaterials. 29(11): 1705-12.
2887. Lamb JS, Zoltowski BD, Pabit SA, Crane BR, Pollack L. (2008) Time-resolved
dimerization of a pas-lov protein measured with photocoupled small angle x-ray
scattering. J. Am. Chem. Soc. 130(37): 12226-+.
2888. Le Huerou Y, Gunawardana I, Thomas AA, Boyd SA, de Meese J, Dewolf W,
Gonzales SS, Han M, Hayter L, Kaplan T, Lemieux C, Lee P, Pheneger J, Poch G,
Romoff TT, Sullivan F, Weiler S, Wright SK, Lin J. (2008) Prodrug thiamine analogs as
inhibitors of the enzyme transketolase. Bioorg. Med. Chem. Lett. 18(2): 505-8.
2889. Le Roch KG, Johnson JR, Ahiboh H, Chung DWD, Prudhomme J, Plouffe D,
Henson K, Zhou YY, Witola W, Yates JR, Ben Mamoun C, Winzeler EA, Vial H. (2008)
A systematic approach to understand the mechanism of action of the bisthiazolium
compound t4 on the human malaria parasite, plasmodium falciparum. BMC Genomics.
9: 15.
2890. Le-Niculescu H, McFarland MJ, Ogden CA, Balaraman Y, Patel S, Tan J, Rodd
ZA, Paulus M, Geyer MA, Edenberg HJ, Glatt SJ, Faraone SV, Nurnberger JI,

Kuczenski R, Tsuang MT, Niculescu AB. (2008) Rapid publication: Phenomic,
convergent functional genomic, and biomarker studies in a stress-reactive genetic
animal model of bipolar disorder and co-morbid alcoholism. Am. J. Med. Genet. B.
147B(2): 134-66.
2891. Lee H, Kim KW, Park J, Kim H, Kim S, Kim D, Hu XQ, Yang WT, Hong JY.
(2008) A general strategy for construction of both 2,6-cis- and 2,6-trans-disubstituted
tetrahydropyrans: Substrate-controlled asymmetric total synthesis of (+)-scanlonenyne.
Angew. Chem.-Int. Edit. 47(22): 4200-3.
2892. Lee JE, Fusco ML, Hessell AJ, Oswald WB, Burton DR, Saphire EO. (2008)
Structure of the ebola virus glycoprotein bound to an antibody from a human survivor.
Nature. 454(7201): 177-U27.
2893. Lee JE, Kuehne A, Abelson DM, Fusco ML, Hart MK, Saphire EM. (2008)
Complex of a protective antibody with its ebola virus gp peptide epitope: Unusual
features of a v lambda(x) light chain. J. Mol. Biol. 375(1): 202-16.
2894. Lee JH, Byeon SR, Kim Y, Lim SJ, Oh SJ, Moon DH, Yoo KH, Chung BY, Kim
DJ. (2008) [f-18]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential
pet imaging agents for detection of beta-amyloid fibrils. Bioorg. Med. Chem. Lett.
18(20): 5701-4.
2895. Lee KK, Gan L, Tsuruta H, Moyer C, Conway JF, Duda RL, Hendrix RW, Steven
AC, Johnson JE. (2008) Virus capsid expansion driven by the capture of mobile surface
loops. Structure. 16(10): 1491-502.
2896. Li L, Chang B, Cheng C, Chang D, Hawes NL, Xia CH, Gong XH. (2008) Dense
nuclear cataract caused by the gamma b-crystallin s11r point mutation. Invest.
Ophthalmol. Vis. Sci. 49(1): 304-9.
2897. Liang PH, Imamura M, Li XM, Wu D, Fujio M, Guy RT, Wu BC, Tsuji M, Wong
CH. (2008) Quantitative microarray analysis of intact glycolipid - cd1d interaction and
correlation with cell-based cytokine production. J. Am. Chem. Soc. 130(37): 12348-54.
2898. Lin B, Koizumi A, Tanaka N, Panda S, Masland RH. (2008) Restoration of visual
function in retinal degeneration mice by ectopic expression of melanopsin. Proc. Natl.
Acad. Sci. U. S. A. 105(41): 16009-14.
2899. Lis ET, O'Neill BM, Gil-Lamaignere C, Chin JK, Romesberg FE. (2008)
Identification of pathways controlling DNA damage induced mutation in saccharomyces
cerevisiae. DNA Repair. 7(5): 801-10.
2900. Littlefield KP, Ward AB, Chappie JS, Reedy MK, Bernstein SI, Milligan RA,
Reedy MC. (2008) Similarities and differences between frozen-hydrated, rigor acto-s1
complexes of insect flight and chicken skeletal muscles. J. Mol. Biol. 381(3): 519-28.
2901. Liu LX, Foroud T, Xuei XL, Berrettini W, Byerley W, Coryell W, El-Mallakh R,
Gershon ES, Kelsoe JR, Lawson WB, MacKinnon DF, McInnis M, McMahon FJ, Murphy
DL, Rice J, Scheftner W, Zandi PP, Lohoff FW, Niculescu AB, Meyer ET, Edenberg HJ,
Nurnberger JI. (2008) Evidence of association between brain-derived neurotrophic
factor gene and bipolar disorder. Psychiatr. Genet. 18(6): 267-74.
2902. Liu Y, Wu J, Weissig H, Betancort JM, Gai WZ, Leventhal PS, Patricelli MP,
Samii B, Szardenings AK, Shreder KR, Kozarich JW. (2008) Design and synthesis of
ax4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase c alpha and

eta. Bioorg. Med. Chem. Lett. 18(22): 5955-8.
2903. Liu YH, Ding Q, Wu X. (2008) Rearrangement of n,n-di-tertbutoxycarbonylpyridin-4-amines
and formation of polyfunctional pyridines. J. Org.
Chem. 73(15): 6025-8.
2904. Lowery CA, Dickerson TJ, Janda KD. (2008) Interspecies and interkingdom
communication mediated by bacterial quorum sensing. Chem. Soc. Rev. 37(7): 1337-
46.
2905. Lowery CA, Park J, Kaufmann GF, Janda KD. (2008) An unexpected switch in
the modulation of ai-2-based quorum sensing discovered through synthetic 4,5dihydroxy-2,3-pentanedione
analogues. J. Am. Chem. Soc. 130(29): 9200-+.
2906. Lu M, Zhu D, Lu YP, Hou YX, Tan B, Zhong GF. (2008) Organocatalytic
asymmetric alpha-aminoxylation/aza-michael reactions for the synthesis of
functionalized tetrahydro-1,2-oxazines. Angew. Chem.-Int. Edit. 47(52): 10187-91.
2907. Ma MM, Paredes A, Bong D. (2008) Intra- and intermembrane pairwise molecular
recognition between synthetic hydrogen-bonding phospholipids. J. Am. Chem. Soc.
130(44): 14456-+.
2908. Maccarrone M, Rossi S, Bari M, De Chiara V, Fezza F, Musella A, Gasperi V,
Prosperetti C, Bernardi G, Finazzi-Agro A, Cravatt BF, Centonze D. (2008) Anandamide
inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum.
Nat. Neurosci. 11(2): 152-9.
2909. Maimone TJ, Voica AF, Baran PS. (2008) A concise approach to vinigrol. Angew.
Chem.-Int. Edit. 47(16): 3054-6.
2910. Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu FY, McKerrow JH,
Guy RK. (2008) Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain
and tbcatb. Bioorg. Med. Chem. Lett. 18(9): 2883-5.
2911. Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M,
Greenbaum D, McKerrow JH, Guy RK. (2008) Development of potent purine-derived
nitrile inhibitors of the trypanosomal protease tbcatb. J. Med. Chem. 51(3): 545-52.
2912. Mallaun M, Naeher D, Daniels MA, Yachi PP, Hausmann B, Luescher IF,
Gascoigne NRJ, Palmer E. (2008) The t cell receptor's alpha-chain connecting peptide
motif promotes close approximation of the cd8 coreceptor allowing efficient signal
initiation. J. Immunol. 180(12): 8211-21.
2913. Marcucci KT, Martina Y, Harrison F, Wilson CA, Salomon DR. (2008) Functional
hierarchy of two l domains in porcine endogenous retrovirus (perv) that influence
release and infectivity. Virology. 375(2): 637-45.
2914. Marsilje TH, Alper PB, Lu WS, Mutnick D, Michellys PY, He Y, Karanewsky DS,
Chow D, Gerken A, Lao JM, Kim MJ, Seidel HM, Tian SS. (2008) Optimization of small
molecule agonists of the thrombopoietin (tpo) receptor derived from a benzo[a]
carbazole hit scaffold. Bioorg. Med. Chem. Lett. 18(19): 5259-62.
2915. Martin CL, Overman LE, Rohde JM. (2008) Total synthesis of (+/-)-actinophyllic
acid. J. Am. Chem. Soc. 130(24): 7568-+.
2916. Maupin CM, Saunders MG, Thorpe IF, McKenna R, Silverman DN, Voth GA.
(2008) Origins of enhanced proton transport in the y7f mutant of human carbonic
anhydrase ii. J. Am. Chem. Soc. 130(34): 11399-408.

2917. Mayorov AV, Amara N, Chang JY, Moss JA, Hixon MS, Ruiz DI, Meijler MM,
Zorrilla EP, Janda KD. (2008) Catalytic antibody degradation of ghrelin increases wholebody
metabolic rate and reduces refeeding in fasting mice. Proc. Natl. Acad. Sci. U. S.
A. 105(45): 17487-92.
2918. McDunn JE, Muenzer JT, Rachdi L, Chang KC, Davis CG, Dunne WM, Piwnica-
Worms D, Bernal-Mizrachi E, Hotchkiss RS. (2008) Peptide-mediated activation of akt
and extracellular regulated kinase signaling prevents lymphocyte apoptosis. Faseb J.
22(2): 561-8.
2919. McKie AH, Friedland S, Hof F. (2008) Tetrazoles are potent anion recognition
elements that emulate the disfavored anti conformations of carboxylic acids. Org. Lett.
10(20): 4653-5.
2920. McQuinn K, McIndoe LS, Hof F. (2008) Insights into the post-translational
methylation of arginine from studies of guanidinium-water nanodroplets. Chem.-Eur. J.
14(21): 6483-9.
2921. Medintz IL, Pons T, Delehanty JB, Susumu K, Brunel FM, Dawson PE, Mattoussi
H. (2008) Intracellular delivery of quantum dot-protein cargos mediated by cell
penetrating peptides. Bioconjugate Chem. 19(9): 1785-95.
2922. Meier JL, Barrows-Yano T, Foley TL, Wike CL, Burkart MD. (2008) The unusual
macrocycle forming thioesterase of mycolactone. Mol. Biosyst. 4(6): 663-71.
2923. Meier JL, Mercer AC, Burkart MD. (2008) Fluorescent profiling of modular
biosynthetic enzymes by complementary metabolic and activity based probes. J. Am.
Chem. Soc. 130(16): 5443-+.
2924. Menendez A, Calarese DA, Stanfield RL, Chow KC, Scanlan CN, Kunert R,
Katinger H, Burton DR, Wilson IA, Scott JK. (2008) A peptide inhibitor of hiv-1
neutralizing antibody 2g12 is not a structural mimic of the natural carbohydrate epitope
on gp120. Faseb J. 22(5): 1380-92.
2925. Mercer AC, Meier JL, Hur GH, Smith AR, Burkart MD. (2008) Antibiotic
evaluation and in vivo analysis of alkynyl coenzyme a antimetabolites in escherichia
coli. Bioorg. Med. Chem. Lett. 18(22): 5991-4.
2926. Michels TD, Rhee JU, Vanderwal CD. (2008) Synthesis of delta-tributylstannylalpha,beta,gamma,delta-unsaturated
aldehydes from pyridines. Org. Lett. 10(21): 4787-
90.
2927. Miermont A, Barnhill H, Strable E, Lu XW, Wall KA, Wang Q, Finn MG, Huang
XF. (2008) Cowpea mosaic virus capsid: A promising carrier for the development of
carbohydrate based antitumor vaccines. Chem.-Eur. J. 14(16): 4939-47.
2928. Mileni M, Johnson DS, Wang ZG, Everdeen DS, Liimatta M, Pabst B,
Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, Stevens RC. (2008)
Structure-guided inhibitor design for human faah by interspecies active site conversion.
Proc. Natl. Acad. Sci. U. S. A. 105(35): 12820-4.
2929. Mills KL, Zhu XY, Takayama SC, Thouless MD. (2008) The mechanical
properties of a surface-modified layer on polydimethylsiloxane. J. Mater. Res. 23(1): 37-
48.
2930. Mkrtchyan H, Bosted PE, Adams GS, Ahmidouch A, Angelescu I, Arrington J,
Asaturyan R, Baker OK, Benmouna N, Bertoncini C, Blok HP, Boeglin WU, Breuer H,

Christy ME, Connell SH, Cui Y, Dalton MM, Danagoulian S, Day D, Dodario T, Dunne
JA, Dutta D, El Khayari N, Ent R, Fenker HC, Frolov VV, Gan L, Gaskell D, Hafidi K,
Hinton W, Holt RJ, Horn T, Huber GM, Hungerford E, Jiang X, Jones M, Joo K,
Kalantarians N, Kelly JJ, Keppel CE, Kubarovsky V, Li Y, Liang Y, Malace S, Markowitz
P, McGrath E, McKee P, Meekins DG, Moziak B, Navasardyan T, Niculescu G,
Niculescu I, Opper AK, Ostapenko T, Reimer PE, Reinhold J, Roche J, Rock SE,
Schulte E, Segbefia E, Smith C, Smith GR, Stoler P, Tadevosyan V, Tang L, Ungaro M,
Uzzle A, Vidakovic S, Villano A, Vulcan WF, Wang M, Warren G, Wesselmann F,
Wojtsekhowski B, Wood SA, Xu C, Yuan L, Zheng X, Zhu H. (2008) Transverse
momentum dependence of semi-inclusive pion production. Phys. Lett. B. 665(1): 20-5.
2931. Moreau M, Lee GI, Wang Y, Crane BR, Klessig DF. (2008) Atnos/atnoa1 is a
functional arabidopsis thaliana cgtpase and not a nitric-oxide synthase. J. Biol. Chem.
283(47): 32957-67.
2932. Moree WJ, Kataoka KI, Ramirez-Weinhouse MM, Shiota T, Imai M, Tsutsumi T,
Sudo M, Endo N, Muroga Y, Hada T, Fanning D, Saunders J, Kato Y, Myers PL, Tarby
CM. (2008) Potent antagonists of the ccr2b receptor. Part 3: Sar of the (r)-3aminopyrrolidine
series. Bioorg. Med. Chem. Lett. 18(6): 1869-73.
2933. Mu TW, Fowler DM, Kelly JW. (2008) Partial restoration of mutant enzyme
homeostasis in three distinct lysosomal storage disease cell lines by altering calcium
homeostasis. PLoS. Biol. 6(2): 253-65.
2934. Nelson JD, Kinkead H, Brunel FM, Leaman D, Jensen R, Louis JM, Maruyama T,
Bewley CA, Bowdish K, Clore GM, Dawson PE, Frederickson S, Mage RG, Richman
DD, Burton DR, Zwick MB. (2008) Antibody elicited against the gp41 n-heptad repeat
(nhr) coiled-coil can neutralize hiv-1 with modest potency but non-neutralizing
antibodies also bind to nhr mimetics. Virology. 377(1): 170-83.
2935. Newhouse T, Baran PS. (2008) Total synthesis of (+/-)-psychotrimine. J. Am.
Chem. Soc. 130(33): 10886-+.
2936. Nicolaou KC, Frederick MO, Aversa RJ. (2008) The continuing saga of the
marine polyether biotoxins. Angew. Chem.-Int. Edit. 47(38): 7182-225.
2937. Nicolaou KC, Frederick MO, Burtoloso ACB, Denton RM, Rivas F, Cole KP,
Aversa RJ, Gibe R, Umezawa T, Suzuki T. (2008) Chemical synthesis of the ghijklmno
ring system of maitotoxin. J. Am. Chem. Soc. 130(23): 7466-76.
2938. Nicolaou KC, Zhang H, Ortiz A, Dagneau P. (2008) Total synthesis of the
originally assigned structure of vannusal b. Angew. Chem.-Int. Edit. 47(45): 8605-10.
2939. Nilsson BL, Overman LE, de Alaniz JR, Rohde JM. (2008) Enantioselective total
syntheses of nankakurines a and b: Confirmation of structure and establishment of
absolute configuration. J. Am. Chem. Soc. 130(34): 11297-+.
2940. Nolt MB, Zhao ZJ, Wolkenberg SE. (2008) Controlled derivatization of
polyhalogenated quinolines utilizing selective cross-coupling reactions. Tetrahedron
Lett. 49(19): 3137-41.
2941. Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF,
Casida JE. (2008) Activation of the endocannabinoid system by organophosphorus
nerve agents. Nat. Chem. Biol. 4(6): 373-8.
2942. Nomura DK, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. (2008) Dual

oles of brain serine hydrolase kiaal1363 in ether lipid metabolism and organophosphate
detoxification. Toxicol. Appl. Pharmacol. 228(1): 42-8.
2943. Nyilas R, Dudok B, Urban GM, Mackie K, Watanabe M, Cravatt BF, Freund TF,
Katona I. (2008) Enzymatic machinery for endocannabinoid biosynthesis associated
with calcium stores in glutamatergic axon terminals. J. Neurosci. 28(5): 1058-63.
2944. O'Malley DP, Yamaguchi J, Young IS, Seiple IB, Baran PS. (2008) Total
synthesis of (+/-)-axinellamines a and b. Angew. Chem.-Int. Edit. 47(19): 3581-3.
2945. Oganesyan V, Gao C, Shirinian L, Wu H, Dall'Acqua WF. (2008) Structural
characterization of a human fc fragment engineered for lack of effector functions. Acta
Crystallogr. Sect. D-Biol. Crystallogr. 64: 700-4.
2946. Palmer LC, Newcomb CJ, Kaltz SR, Spoerke ED, Stupp SI. (2008) Biomimetic
systems for hydroxyapatite mineralization inspired by bone and enamel. Chem. Rev.
108(11): 4754-83.
2947. Palmer LC, Stupp SI. (2008) Molecular self-assembly into one-dimensional
nanostructures. Accounts Chem. Res. 41(12): 1674-84.
2948. Park J, Dickerson TJ, Janda KD. (2008) Major sperm protein as a diagnostic
antigen for onchocerciasis. Bioorg. Med. Chem. 16(15): 7206-9.
2949. Park J, Kaufmann GF, Bowen JP, Arbiser JL, Janda KD. (2008) Solenopsin a, a
venom alkaloid from the fire ant solenopsis invicta, inhibits quorum-sensing signaling in
pseudomonas aeruginosa. J. Infect. Dis. 198(8): 1198-201.
2950. Patel SD, Habeski WM, Min H, Zhang JS, Roof R, Snyder B, Bora G, Campbell
B, Li C, Hidayetoglu D, Johnson DS, Chaudhry A, Charlton ME, Kablaoui NM. (2008)
Identification and sar around n-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-
[1,4]diazepan-1-yl]-et hyl}-2-phenoxy-nicotinamide, a selective alpha(2c) adrenergic
receptor antagonist. Bioorg. Med. Chem. Lett. 18(20): 5689-93.
2951. Patra KP, Johnson JR, Cantin GT, Yates JR, Vinetz JM. (2008) Proteomic
analysis of zygote and ookinete stages of the avian malaria parasite plasmodium
gallinaceum delineates the homologous proteomes of the lethal human malaria parasite
plasmodium falciparum. Proteomics. 8(12): 2492-9.
2952. Peck-Palmer OM, Unsinger J, Chang KC, Davis CG, McDunn JE, Hotchkiss RS.
(2008) Deletion of myd88 markedly attenuates sepsis-induced t and b lymphocyte
apoptosis but worsens survival. J. Leukoc. Biol. 83(4): 1009-18.
2953. Pessanha MCR, Dias DP, Filgueira M, Paranhos RRR, de Farias OL. (2008)
Characterization of pipes and adhesives of glassfiber reinforced plastics used in
offshore platforms. Polimeros. 18(1): 70-5.
2954. Pfefferkorn JA, Choi C. (2008) Convenient synthesis of 1,1 '-h-spiro[indoline-3,3
'-piperidine]. Tetrahedron Lett. 49(28): 4372-3.
2955. Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V,
Dillon L, Hanselman JC, Lin ZW, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky
A, Bainbridge G, Caspers N, Kowala M, Tait BD. (2008) Substituted pyrazoles as
hepatoselective hmg-coa reductase inhibitors: Discovery of (3r,5r)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2h-pyrazol-3-yl]-3,5dihydroxyheptanoic
acid (pf-3052334) as a candidate for the treatment of
hypercholesterolemia. J. Med. Chem. 51(1): 31-45.

2956. Pfefferkorn JA, Choi C, Winters T, Kennedy R, Chi LG, Perrin LA, Lu G, Ping
YW, McClanahan T, Schroeder R, Leininger MT, Geyer A, Schefzick S, Atherton J.
(2008) P2y(1) receptor antagonists as novel antithrombotic agents. Bioorg. Med. Chem.
Lett. 18(11): 3338-43.
2957. Pfefferkorn JA, Larsen SD, Van Huis C, Sorenson R, Barton T, Winters T,
Auerbach B, Wu C, Wolfram TJ, Cai H, Welch K, Esmaiel N, Davis J, Bousley R, Olsen
K, Mueller SB, Mertz T. (2008) Substituted oxazolidinones as novel npc1l1 ligands for
the inhibition of cholesterol absorption. Bioorg. Med. Chem. Lett. 18(2): 546-53.
2958. Phakhodee W, Sahakitpichan P, Deechongkit S, Ruchirawat S. (2008)
Investigation of the acid-mediated cyclisation of amide acetal for the synthesis of
benzazepinone. Heterocycles. 75(8): 1963-70.
2959. Pianowski ZL, Winssinger N. (2008) Nucleic acid encoding to program selfassembly
in chemical biology. Chem. Soc. Rev. 37(7): 1330-6.
2960. Pitter K, Bernal F, LaBelle J, Walensky LD. (2008) Dissection of the bcl-2 family
signaling network with stabilized alpha-helices of bcl-2 domains. Methods Enzymol.
446: 387-408.
2961. Pizzey CL, Pomerantz WC, Sung BJ, Yuwono VM, Gellman SH, Hartgerink JD,
Yethiraj A, Abbott NL. (2008) Characterization of nanofibers formed by self-assembly of
beta-peptide oligomers using small angle x-ray scattering. J. Chem. Phys. 129(9): 8.
2962. Pomerantz WC, Yuwono VM, Pizzey CL, Hartgerink JD, Abbott NL, Gellman SH.
(2008) Nanofibers and lyotropic liquid crystals from a class of self-assembling betapeptides.
Angew. Chem.-Int. Edit. 47(7): 1241-4.
2963. Pothukanuri S, Pianowski Z, Winssinger N. (2008) Expanding the scope and
orthogonality of pna synthesis. Eur. J. Org. Chem. (18): 3141-8.
2964. Pragani R, Roush WR. (2008) Studies on the synthesis of durhamycin a:
Stereoselective synthesis of a model aglycone. Org. Lett. 10(20): 4613-6.
2965. Prasuhn DE, Kuzelka J, Strable E, Udit AK, Cho SH, Lander GC, Quispe JD,
Diers JR, Bocian DF, Potter C, Carragher B, Finn MG. (2008) Polyvalent display of
heme on hepatitis b virus capsid protein through coordination to hexahistidine tags.
Chem. Biol. 15(5): 513-9.
2966. Prasuhn DE, Singh P, Strable E, Brown S, Manchester M, Finn MG. (2008)
Plasma clearance of bacteriophage q beta particles as a function of surface charge. J.
Am. Chem. Soc. 130(4): 1328-34.
2967. Purse BW, Butterfield SM, Ballester P, Shivanyuk A, Rebek J. (2008) Interaction
energies and dynamics of acid-base pairs isolated in cavitands. J. Org. Chem. 73(17):
6480-8.
2968. Purse BW, Tran LH, Piera J, Akermark B, Backvall JE. (2008) Synthesis of new
hybrid hydroquinone/cobalt schiff base catalysts: Efficient electron-transfer mediators in
aerobic oxidation. Chem.-Eur. J. 14(25): 7500-3.
2969. Qiu J, Gyorokos A, Tarasow TM, Guiles J. (2008) Grignard cross-coupling
amenable to large scale production of alpha-fluorostyryl and alphafluorovinylthiophenes.
J. Org. Chem. 73(24): 9775-7.
2970. Rajasekaran MR, Jiang YF, Bhargava V, Littlefield R, Lee A, Lieber RL, Mittal
RK. (2008) Length-tension relationship of the external anal sphincter muscle:

Implications for the anal canal function. Am. J. Physiol.-Gastroint. Liver Physiol. 295(2):
G367-G73.
2971. Raushel J, Pitram SM, Fokin VV. (2008) Efficient synthesis of sulfonyl azides
from sulfonamides. Org. Lett. 10(16): 3385-8.
2972. Redmond WL, Wei CH, Kreuwel HTC, Sherman LA. (2008) The apoptotic
pathway contributing to the deletion of naive cd8 t cells during the induction of
peripheral tolerance to a cross-presented self-antigen. J. Immunol. 180(8): 5275-82.
2973. Reixach N, Foss TR, Santelli E, Pascual J, Kelly JW, Buxbaum JN. (2008)
Human-murine transthyretin heterotetramers are kinetically stable and nonamyloidogenic
- a lesson in the generation of transgenic models of diseases involving
oligomeric proteins. J. Biol. Chem. 283(4): 2098-107.
2974. Rickert KW, Schaber M, Torrent M, Neilson LA, Tasber ES, Garbaccio R,
Coleman PJ, Harvey D, Zhang Y, Yang Y, Marshall G, Lee L, Walsh ES, Hamilton K,
Buser CA. (2008) Discovery and biochemical characterization of selective atp
competitive inhibitors of the human mitotic kinesin ksp. Arch. Biochem. Biophys. 469(2):
220-31.
2975. Rimmerman N, Bradshaw HB, Hughes HV, Chen JSC, Hu SSJ, McHugh D,
Vefring E, Jahnsen JA, Thompson EL, Masuda K, Cravatt BF, Burstein S, Vasko MR,
Prieto AL, O'Dell DK, Walker JM. (2008) N-palmitoyl glycine, a novel endogenous lipid
that acts as a modulator of calcium influx and nitric oxide production in sensory neurons.
Mol. Pharmacol. 74(1): 213-24.
2976. Roecker AJ, Coleman PJ. (2008) Orexin receptor antagonists: Medicinal
chemistry and therapeutic potential. Curr. Top. Med. Chem. 8(11): 977-87.
2977. Roth CB, Hanson MA, Stevens RC. (2008) Stabilization of the human beta(2)adrenergic
receptor tm4-tm3-tm5 helix interface by mutagenesis of glu122(3.41), a
critical residue in gpcr structure. J. Mol. Biol. 376(5): 1305-19.
2978. Salisbury CM, Cravatt BF. (2008) Optimization of activity-based probes for
proteomic profiling of histone deacetylase complexes. J. Am. Chem. Soc. 130(7): 2184-
94.
2979. Salt DE, Baxter I, Lahner B. (2008) Ionomics and the study of the plant ionome.
Annu. Rev. Plant Biol. 59: 709-33.
2980. Sarver RW, Bills E, Bolton G, Bratton LD, Caspers NL, Dunbar JB, Harris MS,
Hutchings RH, Kennedy RM, Larsen SD, Pavlovsky A, Pfefferkorn JA, Bainbridge G.
(2008) Thermodynamic and structure guided design of statin based inhibitors of 3hydroxy-3-methylglutaryl
coenzyme a reductase. J. Med. Chem. 51(13): 3804-13.
2981. Savaldi-Goldstein S, Baiga TJ, Pojer F, Dabi T, Butterfield C, Parry G, Santner A,
Dharmasiri N, Tao Y, Estelle M, Noel JP, Chory J. (2008) New auxin analogs with
growth-promoting effects in intact plants reveal a chemical strategy to improve hormone
delivery. Proc. Natl. Acad. Sci. U. S. A. 105(39): 15190-5.
2982. Schaiberger AM, Moss JA. (2008) Optimized sample preparation for maldi mass
spectrometry analysis of protected synthetic peptides. J. Am. Soc. Mass. Spectrom.
19(4): 614-9.
2983. Scheinost JC, Wang H, Boldt GE, Offer J, Wentworth P. (2008) Cholesterol secosterol-induced
aggregation of methylated amyloid-beta peptides - insights into aldehyde-

initiated fibrillization of amyloid-beta. Angew. Chem.-Int. Edit. 47(21): 3919-22.
2984. Schnell JR, Chou JJ. (2008) Structure and mechanism of the m2 proton channel
of influenza a virus. Nature. 451(7178): 591-U12.
2985. Schroeder GM, Chen XT, Williams DK, Nirschl DS, Cai ZW, Wei D, Tokarski JS,
An YM, Sack J, Chen Z, Huynh T, Vaccaro WN, Poss M, Wautlet B, Gullo-Brown J,
Kellar K, Manne V, Hunt JT, Wong TW, Lombardo LJ, Fargnoli J, Borzilleri RM. (2008)
Identification of pyrrolo[2,1-f][1,2,4] triazine-based inhibitors of met kinase. Bioorg. Med.
Chem. Lett. 18(6): 1945-51.
2986. Schwulst SJ, Muenzer JT, Peck-Palmer OM, Chang KC, Davis CG, McDonough
JS, Osborne DF, Walton AH, Unsinger J, McDunn JE, Hotchkiss RS. (2008) Bim sirna
decreases lymphocyte apoptosis and improves survival in sepsis. Shock. 30(2): 127-34.
2987. Seike H, Sorensen EJ. (2008) A synthesis of the tricyclic core structure of
fr901483 featuring an ugi four-component coupling and a remarkably selective
elimination reaction. Synlett. (5): 695-701.
2988. Shao YM, Yang WB, Kuo TH, Tsai KC, Lin CH, Yang AS, Liang PH, Wong CH.
(2008) Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of sarscov
3cl protease. Bioorg. Med. Chem. 16(8): 4652-60.
2989. Shenvi RA, Guerrero CA, Shi J, Li CC, Baran PS. (2008) Synthesis of (+)cortistatin
a. J. Am. Chem. Soc. 130(23): 7241-+.
2990. Shi CS, Shi GY, Hsiao SM, Kao YC, Kuo KL, Ma CY, Kuo CH, Chang BI, Chang
CF, Lin CH, Wong CH, Wu HL. (2008) Lectin-like domain of thrombomodulin binds to its
specific ligand lewis y antigen and neutralizes lipopolysaccharide-induced inflammatory
response. Blood. 112(9): 3661-70.
2991. Shi Y, Desponts C, Do JT, Hahm HS, Scholer HR, Ding S. (2008) Induction of
pluripotent stem cells from mouse embryonic fibroblasts by oct4 and klf4 with smallmolecule
compounds. Cell Stem Cell. 3(5): 568-74.
2992. Shi Y, Do JT, Desponts C, Hahm HS, Scholer HR, Ding S. (2008) A combined
chemical and genetic approach for the generation of induced pluripotent stem cells. Cell
Stem Cell. 2(6): 525-8.
2993. Shibuya GM, Kanady JS, Vanderwal CD. (2008) Stereoselective dichlorination of
allylic alcohol derivatives to access key stereochemical arrays of the chlorosulfolipids. J.
Am. Chem. Soc. 130(37): 12514-8.
2994. Shih C, Museth AK, Abrahamsson M, Blanco-Rodriguez AM, Di Bilio AJ,
Sudhamsu J, Crane BR, Ronayne KL, Towrie M, Vlcek A, Richards JH, Winkler JR,
Gray HB. (2008) Tryptophan-accelerated electron flow through proteins. Science.
320(5884): 1760-2.
2995. Shipe WD, Barrow JC, Yang ZQ, Lindsley CW, Yang FV, Schlegel KAS, Shu Y,
Rittle KE, Bock MG, Hartman GD, Tang C, Ballard JE, Kuo Y, Adarayan ED,
Prueksaritanont T, Zrada MM, Uebele VN, Nuss CE, Connolly TM, Doran SM, Fox SV,
Kraus RL, Marino MJ, Gratifelds VK, Vargas HM, Bunting PB, Hasbun-Manning M,
Evans RM, Koblan KS, Renger JJ. (2008) Design, synthesis, and evaluation of a novel
4-aminomethyl-4-fluoropiperidine as a t-type ca2+ channel antagonist. J. Med. Chem.
51(13): 3692-5.
2996. Shue YK, Sears PS, Shangle S, Walsh RB, Lee C, Gorbach SL, Okumu F,

Preston RA. (2008) Safety, tolerance, and pharmacokinetic studies of opt-80 in healthy
volunteers following single and multiple oral doses. Antimicrob. Agents Chemother.
52(4): 1391-5.
2997. Simon GM, Cravatt BF. (2008) Anandamide biosynthesis catalyzed by the
phosphodiesterase gde1 and detection of glycerophospho-n-acyl ethanolamine
precursors in mouse brain. J. Biol. Chem. 283(14): 9341-9.
2998. Simon GM, Cravatt BF. (2008) Challenges for the 'chemical-systems' biologist.
Nat. Chem. Biol. 4(11): 639-42.
2999. Siu T, Li YW, Nagasawa J, Liang J, Tehrani L, Chua P, Jones RE, Defeo-Jones
D, Barnett SF, Robinson RG. (2008) The design and synthesis of potent and cell-active
allosteric dual akt 1 and 2 inhibitors devoid of herg activity. Bioorg. Med. Chem. Lett.
18(14): 4191-4.
3000. Siu T, Liang J, Arruda J, Li YW, Jones RE, Defeo-Jones D, Barnett SF, Robinson
RG. (2008) Discovery of potent and cell-active allosteric dual akt 1 and 2 inhibitors.
Bioorg. Med. Chem. Lett. 18(14): 4186-90.
3001. Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, Stevens
RC. (2008) Correlation of inhibitor effects on enzyme activity and thermal stability for the
integral membrane protein fatty acid amide hydrolase. Bioorg. Med. Chem. Lett. 18(22):
5847-50.
3002. Smith BA, Daniels DS, Coplin AE, Jordan GE, McGregor LM, Schepartz A.
(2008) Minimally cationic cell-permeable miniature proteins via alpha-helical arginine
display. J. Am. Chem. Soc. 130(10): 2948-9.
3003. Spencer MT, Furutani H, Oldenburg SJ, Darlington TK, Prather KA. (2008) Gold
nanoparticles as a matrix for visible-wavelength single-particle matrix-assisted laser
desorption/ionization mass spectrometry of small biomolecules. J. Phys. Chem. C.
112(11): 4083-90.
3004. Steinhardt SE, Silverston JS, Vanderwal CD. (2008) Stereocontrolled synthesis
of z-dienes via an unexpected pericyclic cascade rearrangement of 5-amino-2,4pentadienals.
J. Am. Chem. Soc. 130(24): 7560-+.
3005. Strable E, Prasuhn DE, Udit AK, Brown S, Link AJ, Ngo JT, Lander G, Quispe J,
Potter CS, Carragher B, Tirrell DA, Finn MG. (2008) Unnatural amino acid incorporation
into virus-like particles. Bioconjugate Chem. 19(4): 866-75.
3006. Suarez J, Bermudez-Silva FJ, Mackie K, Ledent C, Zimmer A, Cravatt BF, de
Fonseca FR. (2008) Immunohistochemical description of the endogenous cannabinoid
system in the rat cerebellum and functionally related nuclei. J. Comp. Neurol. 509(4):
400-21.
3007. Sudhamsu J, Lee GI, Klessig DF, Crane BR. (2008) The structure of yqeh an
atnos1/atnoa1 ortholog that couples gtp hydrolysis to molecular recognition. J. Biol.
Chem. 283(47): 32968-76.
3008. Sutherland JJ, Higgs RE, Watson I, Vieth M. (2008) Chemical fragments as
foundations for understanding target space and activity prediction. J. Med. Chem. 51(9):
2689-700.
3009. Sweeney ZK, Dunn JP, Li Y, Heilek G, Dunten P, Elworthy TR, Han X, Harris SF,
Hirschfeld DR, Hogg JH, Huber W, Kaiser AC, Kertesz DJ, Kim W, Mirzadegan T,

Roepel MG, Saito YD, Silva T, Swallow S, Tracy JL, Villasenor A, Vora H, Zhou AS,
Klumpp K. (2008) Discovery and optimization of pyridazinone non-nucleoside inhibitors
of hiv-1 reverse transcriptase. Bioorg. Med. Chem. Lett. 18(15): 4352-4.
3010. Syson K, Tomlinson C, Chapados BR, Sayers JR, Tainer JA, Williams NH,
Grasby JA. (2008) Three metal ions participate in the reaction catalyzed by t5 flap
endonuclease. J. Biol. Chem. 283(42): 28741-6.
3011. Tagore R, Thomas HR, Homan EA, Munawar A, Saghatelian A. (2008) A global
metabolite profiling approach to identify protein-metabolite interactions. J. Am. Chem.
Soc. 130(43): 14111-+.
3012. Tamiya J, Dyck B, Zhang MZ, Phan K, Fleck BA, Aparicio A, Jovic F, Tran JA,
Vickers T, Grey J, Foster AC, Chen C. (2008) Identification of 1s, 2r-milnacipran
analogs as potent norepinephrine and serotonin transporter inhibitors. Bioorg. Med.
Chem. Lett. 18(11): 3328-32.
3013. Tan B, Chua PJ, Li YX, Zhong GF. (2008) Organocatalytic asymmetric tandem
michael-henry reactions: A highly stereoselective synthesis of multifunctionalized
cyclohexanes with two quaternary stereocenters. Org. Lett. 10(12): 2437-40.
3014. Tan B, Chua PJ, Zeng XF, Lu M, Zhong GF. (2008) A highly diastereo- and
enantioselective synthesis of multisubstituted cyclopentanes with four chiral carbons by
the organocatalytic domino michael-henry reaction. Org. Lett. 10(16): 3489-92.
3015. Tan B, Shi ZG, Chua PJ, Zhong GF. (2008) Control of four stereocenters in an
organocatalytic domino double michael reaction: Efficient synthesis of multisubstituted
cyclopentanes. Org. Lett. 10(16): 3425-8.
3016. Tao Y, Ferrer JL, Ljung K, Pojer F, Hong FX, Long JA, Li L, Moreno JE, Bowman
ME, Ivans LJ, Cheng YF, Lim J, Zhao YD, Ballare CL, Sandberg G, Noel JP, Chory J.
(2008) Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for
shade avoidance in plants. Cell. 133(1): 164-76.
3017. Thomas AA, De Meese J, Le Huerou Y, Boyd SA, Romoff TT, Gonzales SS,
Gunawardana I, Kaplan T, Sullivan F, Condroski K, Lyssikatos JP, Aicher TD, Ballard J,
Bernat B, DeWolf W, Han M, Lemieux C, Smith D, Weiler S, Wright SK, Vigers G,
Brandhuber B. (2008) Non-charged thiamine analogs as inhibitors of enzyme
transketolase. Bioorg. Med. Chem. Lett. 18(2): 509-12.
3018. Thomas AA, Le Huerou Y, De Meese J, Gunawardana I, Kaplan T, Romoff TT,
Gonzales SS, Condroski K, Boyd SA, Ballard J, Bernat B, DeWolf W, Han M, Lee P,
Lemieux C, Pedersen R, Pheneger J, Poch G, Smith D, Sullivan F, Weiler S, Wright SK,
Lin J, Brandhuber B, Vigers G. (2008) Synthesis, in vitro and in vivo activity of thiamine
antagonist transketolase inhibitors. Bioorg. Med. Chem. Lett. 18(6): 2206-10.
3019. Thorpe IF, Zhou J, Voth GA. (2008) Peptide folding using multiscale coarsegrained
models. J. Phys. Chem. B. 112(41): 13079-90.
3020. Tichenor MS, Boger DL. (2008) Yatakemycin: Total synthesis, DNA alkylation,
and biological properties. Nat. Prod. Rep. 25(2): 220-6.
3021. Topping RJ, Nuiry I, Mastriona J, Moss JA. (2008) Optimized 'inverse activation'
methodology for esterification of hydroxyl-functionalized resins. Tetrahedron Lett.
49(18): 2907-10.
3022. Torres O, Yuksel D, Bernardina M, Kumar K, Bong D. (2008) Peptide tertiary

structure nucleation by side-chain crosslinking with metal complexation and double
"Click" Cycloaddition. Chembiochem. 9(11): 1701-5.
3023. Treweek JB, Sun C, Mayorov AV, Qi L, Levy CL, Roberts AJ, Dickerson TJ,
Janda KD. (2008) Prevention of drug-induced memory impairment by
immunopharmacotherapy. J. Med. Chem. 51(21): 6866-75.
3024. Tuleuova N, An CI, Ramanculov E, Revzin A, Yokobayashi Y. (2008) Modulating
endogenous gene expression of mammalian cells via rna-small molecule interaction.
Biochem. Biophys. Res. Commun. 376(1): 169-73.
3025. Tully DC, Vidal A, Chatterjee AK, Williams JA, Roberts MJ, Petrassi HM,
Spraggon G, Bursulaya B, Pacoma R, Shipway A, Schumacher AM, Danahay H, Harris
JL. (2008) Discovery of inhibitors of the channel-activating protease prostasin
(cap1/prss8) utilizing structure-based design. Bioorg. Med. Chem. Lett. 18(22): 5895-9.
3026. Turman MV, Kingsley PJ, Rouzer CA, Cravatt BF, Marnett LJ. (2008) Oxidative
metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.
Biochemistry. 47(12): 3917-25.
3027. Vale C, Wandscheer C, Nicolaou KC, Frederick MO, Alfonso C, Vieytes MR,
Botana LM. (2008) Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in
cultured neurons: Involvement of the c-jun n-terminal kinase. J. Neurosci. Res. 86(13):
2952-62.
3028. van der Staay FJ, Rutten K, Barfacker L, Devry J, Erb C, Heckroth H, Karthaus
D, Tersteegen A, van Kampen M, Blokland A, Prickaerts J, Reymann KG, Schroder UH,
Hendrix M. (2008) The novel selective pde9 inhibitor bay 73-6691 improves learning
and memory in rodents. Neuropharmacology. 55(5): 908-18.
3029. Vela JL, Aft-Azzouzene D, Duong BH, Ota T, Nernazee D. (2008)
Rearrangement of mouse immunoglobulin kappa deleting element recombining
sequence promotes immune tolerance and lambda b cell production. Immunity. 28(2):
161-70.
3030. Vickers T, Dyck B, Tamiya J, Zhang MZ, Jovic F, Grey J, Fleck BA, Aparicio A,
Johns M, Jin LP, Tang H, Foster AC, Chen C. (2008) Studies on a series of milnacipran
analogs containing a heteroaromatic group as potent norepinephrine and serotonin
transporter inhibitors. Bioorg. Med. Chem. Lett. 18(11): 3230-5.
3031. Vilarino N, Nicolaou KC, Frederick MO, Cagide E, Alfonso C, Alonso E, Vieytes
MR, Botana LM. (2008) Azaspiracid substituent at c1 is relevant to in vitro toxicity.
Chem. Res. Toxicol. 21(9): 1823-31.
3032. Voelcker NH, Guckian KM, Saghatelian A, Ghadiri MR. (2008) Sequenceaddressable
DNA logic. Small. 4(4): 427-31.
3033. Vosburg DA. (2008) Teaching organic synthesis: A comparative case study
approach. J. Chem. Educ. 85(11): 1519-23.
3034. Wang HX, Ruan ZM, Li JJ, Simpkins LM, Smirk RA, Wu SC, Hutchins RD,
Nirschl DS, Van Kirk K, Cooper CB, Sutton JC, Ma ZP, Golla R, Seethala R, Salyan
MEK, Nayeem A, Krystek SR, Sheriff S, Camac DM, Morin PE, Carpenter B, Robl JA,
Zahler R, Gordon DA, Hamann LG. (2008) Pyridine amides as potent and selective
inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1. Bioorg. Med. Chem. Lett.
18(11): 3168-72.

3035. Wang M, Boddy CN. (2008) Examining the role of hydrogen bonding interactions
in the substrate specificity for the loading step of polyketide synthase thioesterase
domains. Biochemistry. 47(45): 11793-803.
3036. Wang SK, Liang PH, Astronomo RD, Hsu TL, Hsieh SL, Burton DR, Wong CH.
(2008) Targeting the carbohydrates on hiv-1: Interaction of oligomannose dendrons with
human monoclonal antibody 2g12 and dc-sign. Proc. Natl. Acad. Sci. U. S. A. 105(10):
3690-5.
3037. Weerapana E, Simon GM, Cravatt BF. (2008) Disparate proteome reactivity
profiles of carbon electrophiles. Nat. Chem. Biol. 4(7): 405-7.
3038. Wei F, Zhang DM, Halas NJ, Hartgerink JD. (2008) Aromatic amino acids
providing characteristic motifs in the raman and sers spectroscopy of peptides. J. Phys.
Chem. B. 112(30): 9158-64.
3039. White JT, Martell LA, Prince WS, Boyer R, Crockett L, Cox C, Van Tuyl A,
Aguilera A, Foehr E. (2008) Comparison of neutralizing antibody assays for receptor
binding and enzyme activity of the enzyme replacement therapeutic naglazyme
(galsulfase). Aaps Journal. 10(3): 439-49.
3040. White JT, Martell LA, Van Tuyl A, Boyer R, Warness L, Taniguchi GT, Foehr E.
(2008) Development, validation, and clinical implementation of an assay to measure
total antibody response to naglazyme (r) (galsulfase). Aaps Journal. 10(2): 363-72.
3041. Willis B, Eubanks LM, Dickerson TJ, Janda KD. (2008) The strange case of the
botulinum neurotoxin: Using chemistry and bilogy to modulate the most deadly poison.
Angew. Chem.-Int. Edit. 47(44): 8360-79.
3042. Willis B, Eubanks LM, Wood MR, Janda KD, Dickerson TJ, Lerner RA. (2008)
Biologically templated organic polymers with nanoscale order. Proc. Natl. Acad. Sci. U.
S. A. 105(5): 1416-9.
3043. Wilson-Kubalek EM, Cheeseman IM, Yoshioka C, Desai A, Milligan RA. (2008)
Orientation and structure of the ndc80 complex on the microtubule lattice. J. Cell Biol.
182(6): 1055-61.
3044. Wise LE, Cannavacciulo R, Cravatt BF, Martin BF, Lichtman AH. (2008)
Evaluation of fatty acid amides in the carrageenan-induced paw edema model.
Neuropharmacology. 54(1): 181-8.
3045. Wolkenberg SE, Thut CJ. (2008) Recent progress in the discovery of selective,
non-peptide ligands of somatostatin receptors. Curr. Opin. Drug Discov. Dev. 11(4):
446-57.
3046. Worthington AS, Hur GH, Meier JL, Cheng Q, Moore BS, Burkart MD. (2008)
Probing the compatibility of type ii ketosynthase-carrier protein partners. Chembiochem.
9(13): 2096-103.
3047. Wu CL, Delano DL, Mitro N, Su SV, Janes J, McClurg P, Batalov S, Welch GL,
Zhang J, Orth AP, Walker JR, Glynne RJ, Cooke MP, Takahashi JS, Shimomura K,
Kohsaka A, Bass J, Saez E, Wiltshire T, Su AI. (2008) Gene set enrichment in eqtl data
identifies novel annotations and pathway regulators. PLoS Genet. 4(5): 11.
3048. Wu D, Fujio M, Wong CH. (2008) Glycolipids as immunostimulating agents.
Bioorg. Med. Chem. 16(3): 1073-83.
3049. Wu P, Chen X, Hu N, Tam UC, Blixt O, Zettl A, Bertozzi CR. (2008)

Biocompatible carbon nanotubes generated by functionalization with glycodendrimers.
Angew. Chem.-Int. Edit. 47(27): 5022-5.
3050. Xia CH, Liu HQ, Cheung D, Wang M, Cheng C, Du X, Chang B, Beutler B, Gong
XH. (2008) A model for familial exudative vitreoretinopathy caused by lpr5 mutations.
Hum. Mol. Genet. 17(11): 1605-12.
3051. Xu CQ, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ,
Wucherpfennig KW. (2008) Regulation of t cell receptor activation by dynamic
membrane binding of the cd3 epsilon cytoplasmic tyrosine-based motif. Cell. 135(4):
702-13.
3052. Xu Y, Shi Y, Ding S. (2008) A chemical approach to stem-cell biology and
regenerative medicine. Nature. 453(7193): 338-44.
3053. Yamaguchi J, Seiple IB, Young IS, O'Malley DP, Maue M, Baran PS. (2008)
Synthesis of 1,9-dideoxy-pre-axinellamine. Angew. Chem.-Int. Edit. 47(19): 3578-80.
3054. Yamamoto N, Tanabe Y, Okamoto R, Dawson PE, Kajihara Y. (2008) Chemical
synthesis of a glycoprotein having an intact human complex-type sialyloligosaccharide
under the boc and fmoc synthetic strategies. J. Am. Chem. Soc. 130(2): 501-10.
3055. Yang ZQ, Barrow JC, Shipe WD, Schlegel KAS, Shu YS, Yang FV, Lindsley CW,
Rittle KE, Bock MG, Hartman GD, Uebele VN, Nuss CE, Fox SV, Kraus RL, Doran SM,
Connolly TM, Tang CY, Ballard JE, Kuo YS, Adarayan ED, Prueksaritanont T, Zrada
MM, Marino MJ, Graufelds VK, DiLella AG, Reynolds IJ, Vargas HM, Bunting PB,
Woltmann RF, Magee MM, Koblan KS, Renger JJ. (2008) Discovery of 1,4-substituted
piperidines as potent and selective inhibitors of t-type calcium channels. J. Med. Chem.
51(20): 6471-7.
3056. Yegneswaran S, Hackeng TM, Dawson PE, Griffin JH. (2008) The thrombinsensitive
region of protein s mediates phospholipid-dependent interaction with factor xa.
J. Biol. Chem. 283(48): 33046-52.
3057. Ying YC, Liu YX, Byeon SR, Kim H, Luesch H, Hong JY. (2008) Synthesis and
activity of largazole analogues with linker and macrocycle modification. Org. Lett.
10(18): 4021-4.
3058. Ying YC, Taori K, Kim H, Hong JY, Luesch H. (2008) Total synthesis and
molecular target of largazole, a histone deacetylase inhibitor. J. Am. Chem. Soc.
130(26): 8455-9.
3059. Yoneda Y, Steiniger SCJ, Capkova K, Mee JM, Liu Y, Kaufmann GF, Janda KD.
(2008) A cell-penetrating peptidic grp78 ligand for tumor cell-specific prodrug therapy.
Bioorg. Med. Chem. Lett. 18(5): 1632-6.
3060. Young JA, Johnson JR, Benner C, Yan SF, Chen K, Le Roch KG, Zhou YY,
Winzeler EA. (2008) In silico discovery of transcription regulatory elements in
plasmodium falciparum. BMC Genomics. 9: 21.
3061. Yu WM, Guvench O, MacKerell AD, Qu CK. (2008) Identification of small
molecular weight inhibitors of src homology 2 domain-containing tyrosine phosphatase 2
(shp-2) via in silico database screening combined with experimental assay. J. Med.
Chem. 51(23): 7396-404.
3062. Yu XF, Li L, Guo M, Chory J, Yin YH. (2008) Modulation of brassinosteroidregulated
gene expression by jumonji domain-containing proteins elf6 and ref6 in

arabidopsis. Proc. Natl. Acad. Sci. U. S. A. 105(21): 7618-23.
3063. Zhang F, Klebansky B, Fine RM, Xu H, Pronin A, Liu HT, Tachdjian C, Li XD.
(2008) Molecular mechanism for the umami taste synergism. Proc. Natl. Acad. Sci. U.
S. A. 105(52): 20930-4.
3064. Zhang Y, Narayan S, Geiman E, Lanuza GM, Velasquez T, Shanks B, Akay T,
Dyck J, Pearson K, Gosgnach S, Fan CM, Goulding M. (2008) V3 spinal neurons
establish a robust and balanced locomotor rhythm during walking. Neuron. 60(1): 84-96.
3065. Zhao ZJ, Wolkenberg SE, Lu MQ, Munshi V, Moyer G, Feng MZ, Carella AV,
Ecto LT, Gabryelski LJ, Lai MT, Prasad SG, Yan Y, McGaughey GB, Miller MD, Lindsley
CW, Hartman GD, Vacca JP, Williams TM. (2008) Novel indole-3-sulfonamides as
potent hiv non-nucleoside reverse transcriptase inhibitors (nnrtis). Bioorg. Med. Chem.
Lett. 18(2): 554-9.
3066. Zhou JC, Bhattacharjee A, Chen SL, Chen Y, Duffy E, Farmer J, Goldberg J,
Hanselmann R, Ippolito JA, Lou RL, Orbin A, Oyelere A, Salvino J, Springer D, Tran J,
Wang DP, Wu YS, Johnson G. (2008) Design at the atomic level: Design of
biaryloxazolidinones as potent orally active antibiotics. Bioorg. Med. Chem. Lett. 18(23):
6175-8.
3067. Zhou JC, Bhattacharjee A, Chen SL, Chen Y, Duffy E, Farmer J, Goldberg J,
Hanselmann R, Ippolito JA, Lou RL, Orbin A, Oyelere A, Salvino J, Springer D, Tran J,
Wang DP, Wu YS, Johnson G. (2008) Design at the atomic level: Generation of novel
hybrid biaryloxazolidinones as promising new antibiotics. Bioorg. Med. Chem. Lett.
18(23): 6179-83.
3068. Zhu D, Lu M, Chua J, Tan B, Wang F, Yang XH, Zhong GF. (2008) A highly
stereoselective organocatalytic tandem aminoxylation/aza-michael reaction for the
synthesis of tetrahydro-1,2-oxazines. Org. Lett. 10(20): 4585-8.
3069. Zoltowski BD, Crane BR. (2008) Light activation of the lov protein vivid generates
a rapidly exchanging dimer. Biochemistry. 47(27): 7012-9.
3070. Antonysamy S, Hirst G, Park F, Sprengeler P, Stappenbeck F, Steensma R,
Wilson M, Wong M. (2009) Fragment-based discovery of jak-2 inhibitors. Bioorg. Med.
Chem. Lett. 19(1): 279-82.
3071. Darlington TK, Neigh AM, Spencer MT, Nguyen OT, Oldenburg SJ. (2009)
Nanoparticle charateristics affecting environmental fate and transport through soil.
Environ. Toxicol. Chem. in press.
3072. Karaa ZS, Iacovoni JS, Bastide A, Lacazette E, Touriol C, Prats H. (2009) The
vegf ireses are differentially susceptible to translation inhibition by mir-16. RNA-Publ.
RNA Soc. 15(2): 249-54.
3073. Kim H, Kasper AC, Moon EJ, Park Y, Wooten CM, Dewhirst MW, Hong JY.
(2009) Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers:
Stereoselective synthesis of manassantins a and b. Org. Lett. 11(1): 89-92.
3074. Kim Y, Lee JH, Ryu JY, Kim DJ. (2009) Multivalent and multifunctional ligands to
beta-amyloid. Curr. Pharm. Design. 15(6): 637-58.
3075. Lee J, Hong J, Nam TG, Peters EC, Orth AP, Geierstanger BH, Goldfinger LE,
Ginsberg MH, Cho CY, Schultz PG. (2009) A small molecule inhibitor of α4 integrindependent
cell migration. Bioorg. Med. Chem. 17(3): 977-80.

3076. Strable E, Finn MG. (2009) Chemical modification of viruses and virus-like
particles. Curr. Top. Microbiol. Immunol. 327: 1-21.
3077. Tagore DM, Nolte WM, Neveu JM, Rangel R, Guzman-Rojas L, Pasqualini R,
Arap W, Lane WS, Saghatelian A. (2009) Peptidase substrates via global peptide
profiling. Nat. Chem. Biol. 5(1): 23-5.
3078. Xu H, Woll MG, Zuend SJ, Tao Y, Jacobsen EN. (2009) Asymmetric catalysis of
superacid-catalyzed reactions. Science. submitted.