CURRICULUM VITAE Jean-Louis CARPENTIER ... - Etat de Genève

Jean-Louis CARPENTIER
Né le 31 octobre 1947, Namur (Belgique)
Nationalité : Belge
Marié, 3 enfants
CURRICULUM VITAE
Adresse professionnelle :
Décanat
Faculté de Médecine de l’Université de Genève
CMU
1, Rue Michel Servet
CH- 1211 Genève 4, Suisse
Tel.: 41-22-379 50 01
Fax: 41-22-379 50 02
E-mail:Jean-Louis.Carpentier@medecine.unige.ch
Adresse privée :
31, Chemin du Hameau
CH-1255 Veyrier, Suisse
Tel.: 41-22-7521088
Position actuelle
Doyen de la Faculté de médecine de l’Université de Genève
Doyen délégué au rectorat, membre du rectorat de l’Université de Genève
Professeur ordinaire au Département de Physiologie cellulaire et métabolisme de
l’Université de Genève
Pourcentage de temps dévolu aux activités:
enseignement: 0%
recherche: 10%
administration: 90%
Formation
1965 : Maturité (Section Latin-Mathématiques), Athénée Royal de Namur,
Namur, Belgique.
1968 : Candidat en sciences naturelles et médicales; Facultés Universitaires
Notre-Dame de la Paix, Namur, Belgique.
1972 : Docteur en Médecine, Chirurgie et Accouchements : Université de Liège,
Liège, Belgique.
1975 : Candidat Spécialiste en Médecine Interne, Université de Liège, Liège,
Belgique
Activités professionnelles

2006-présent : Doyen délégué. Membre du rectorat, Université de Genève, Genève,
Suisse
2
2003-présent : Doyen, Faculté de médecine de l’Université de Genève, Genève, Suisse.
1999-2003 : Vice-doyen, Faculté de médecine de l’Université de Genève, Genève,
Suisse.
1996-présent : Professeur ordinaire, Département Morpholgie puis Département de
Physiologie cellulaire et Métabolisme, Faculté de médecine de
l’Université de Genève, Genève, Suisse.
1989-1996 : Professeur adjoint, Département de Morphologie, Faculté de médecine
de l’Université de Genève, Genève, Suisse.
1982-1989 : Maître d’Enseignement et de Recherche, Département de Morphologie,
Faculté de médecine de l’Université de Genève, Genève, Suisse.
1979 (1/6-1/9) : Visiting Scientist, Diabetes Branch, NIDDKD, National Institutes of
Health, Bethesda, Maryland, USA.
1977-1982 : Chargé de Recherche, Département de Morphologie, Faculté de
médecine de l’Université de Genève, Genève, Suisse.
1974-1977 : Assistant, Département de Morphologie, Faculté de médecine de
l’Université de Genève, Genève, Suisse.
1972-1974 : Assistant, Département de Médecine Interne (A), Université de Liège,
Liège, Belgique.
1969-1972 : Elève-Assistant, Département de Pathologie, Université de Liège, Liège,
Belgique.
Enseignement
Depuis 2004, plus d’activité d’enseignement.
Pour le bilan des activités précédemment exercées se référer au renouvellement précédent
Distinctions
1972 : Prix Specia, Liège, Belgique.
1974 : Concours de Bourses de Voyages, Bruxelles, Belgique.
1980 : Pfizer Lecture, Institut de Recherches Cliniques, Montréal, Canada.
1987 : Oskar Minkowski Award de “l’Association Européenne pour l’Etude du
Diabète”, Leipzig, Allemagne.
1988 : Privat Docent, Université de Genève.
1993 : Robert Feulgen Prize de la “Society for Histochemistry”,
Gargelen/Montafon, Autriche.
Sociétés
Membre de : European Association for the Study of Diabetes.
American Diabetes Association.
American Society for Cell Biology.
Union des Sociétés Suisses de Biologie Expérimentale.
Society for Histochemistry.

Fondations
Fonctions scientifiques
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� Fondation Louis-Jeantet : Vice-Président, Membre du Conseil de
Fondation et du Bureau du Conseil de Fondation
� Fondation Carlos et Elsie De Reuter : Président, Membre du Conseil
de Fondation et du Conseil Scientifique.
� Fondation Arditi : Membre du Conseil de Fondation
� Fondation IST : Vice-Président , Membre du Conseil de Fondation
� Fondation AETAS : Membre du Conseil de Fondation
� Fondation ARTERE : Membre du Conseil de Fondation
� Fondation Gertrude Von Meissner : Membre du comité scientifique
genevois
� Fondation pour la Recherche Médicale : Membre du Conseil de
Fondation et du Bureau du Conseil de Fondation
Membre de : Scientific Committee of the International Symposium on Insulin
Receptors and Insulin Action.
Représentant suisse auprès de l’Action COST BM0602 – « Adipose
Tissue . A Key Target for Preventtion of the Metabolic Syndrome » ESF-
OFES
Membre étranger de la Commission « Biologie cellulaire et Biologie du
développement (normales et pathologiques) du FNRS – Bruxelles –
Belgique.
Subsides
1974-2005 : Fonds National Suisse de la Recherche Scientifique [subsides N os :
3.120.77 (subside institutionnel); 3.668.80 (subside institutionnel);
3.460.83 (subside institutionnel); 3.404.86 (subside institutionnel); 31-
266.25.89 (subside institutionnel); 31-34093.92 (requérant principal); 31-
043409.95 (requérant principal); 31-053686.98 (requérant principal); 31-
056830.99 (co-requérant); 31-65392.01 (requérant principal)].
2003-2005 : Action COST B17 (OFES) projet C02.0097.
1992-2003 : Programme National de Recherche sur le Sida [subsides N os : 31-
36063.92 (co-requérant principal); 31-3607248.95 (co-requérant
principal); 3139-055170.98 (requérant principal)].
1998 : Fondation Medic, Genève
1995-1998 : National Institutes of Health (NIH) Bethesda-MD, USA (Fondation
Fogarty): “Collaboration Grant” attribué aux Drs D. Trono et J.-L.
Carpentier pour le projet: “Nef, T-Cells and HIV replication”.
1996-1997 : Roche Research Foundation, Bâle: “Molecular dissection and
physiological relevance of insulin receptor internalization”
1993-1995 : Helmut Horten Stiftung, Madonna del Piano: "Direct morphological
tracking of insulin receptor signal transduction".
1994 : Fondation Centre de Recherches Médicales Carlos et Elsie De
Reuter, Genève:"Endocytose du récepteur CD4 et infection par le virus
HIV".
1993 : Fondation Sandoz pour l'avancement des sciences médicobiologiques,
Bâle: "Direct morphological tracking of insulin receptor
signal transduction".
1993 : The Sir Jules Thorn Charitable Overseas Trust Reg., Schaan: "Cellular
and molecular mechanisms of insulin-induced internalization of its
receptor"

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1993 : Fondation de l'Association Suisse du Diabète, Zürich: "Direct
morphological tracking of insulin receptor signal transduction".
1992 : "SIDA grant": "Recepteurs CD4 à la surface des cellules immunes et
leur régulation par des signaux intracellulaires".
1991-1993 : Juvenile Diabetes Foundation, New York: "Morphological study of the
mechanisms responsible for triggering and regulation of insulin-receptor
internalization in normal and pathological conditions".
1991-1993 : Fondation Centre de Recherches Médicales Carlos et Elsie De
Reuter, Genève: "Etude des mécanismes d'induction et de régulation de
l'internalisation des récepteurs à l'insuline".
1990 : Fondation E. et L. Schmidheiny, Vesenaz: "Le diabète s'accompagne-til
d'une anomalie du facteur de croissance épidermique ?".1985 :
Société d'étude et de recherche pour la pharmacie et l'agriculture,
Suresnes, France: "Etude de l'influence de la Metformine sur
l'internalisation de l'insuline".
1989 : Comité d’aide à la recherche sur le cancer, Genève: "Etude de
l'internalisation de l'EGF dans des cellules tumorales".
1987 : Fondation Sandoz pour l'avancement des sciences médicobiologiques,
Bâle: "Intracellular pathway followed by the phosphorylated
insulin receptor".
1986 : Société Académique de Genève: contribution à l'achat d'un rotor
d'ultracentrifugeuse.
Direction de thèses
Ph.D.
Robert, A. : Aspects morphologiques de l'internalisation de l'insuline marquée à
l'iode 125
dans des conditions normales et pathologiques (1990).
Foti, M. : Régulation de l’internalisation de CD4 dans les cellules myéloïdes et
lymphocytaires. Modulation par la proteine Nef (1996).
Piguet, V. : Nef et downrégulation des récepteurs CD4 et MHC I (2000).
Pagano, A. : COPII Sec24 proteins and protein transport from the endoplasmic
reticulum to the Golgi compartment (2001).
Dudognon, P. : Transport between endoplasmic reticulum and Golgi apparatus : Function
and regulation of the COPII complex (2003).
Iff J. : En cours
M.D.
Barazzone, P. : Binding, internalization and lysosomal association of 125I-human growth
hormone in cultured human lymphocytes: a quantitative morphological
and biochemical study (1981).
Geiger, D. : Relation entre down-regulation des récepteurs insuliniques et
Krischer, J. :
internalisation de l'insuline (1989).
Endocytosis is inhibited in hepatocytes from diabetic rats (1993).
Piguet, V. : Nef et downrégulation des récepteurs CD4 et MHC I (2000).
Diplôme de Biologie
Deschenaux, D. : Essai d'identification de récepteurs aux prohormones polypeptidiques
sur les membranes Golgiennes de cellules de pancréas endocrine (1989)
Balz, J. : Study of the factors controlling endocytosis using a cell-free system
(1995).
Zunwald, N. : Endocytose du récepteur à l’insuline : implication de trois motifs de type
dileucine (1999).

Publications
A. ARTICLES PARUS DANS DES JOURNAUX A POLITIQUE EDITORIALE
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1. BONIVER J., CARPENTIER J.-L., et L.J. SIMAR: Ultrastructure de la population
lymphoïde du thymus chez la souris nouveau-née. Bull. Assoc. Anat. 58, 485-490
(1974).
2. CARPENTIER J.-L., BONIVER J., BETZ E.H., et L.J. SIMAR: Ultrastructural
demonstration of peculiar lymphoid cells in the thymus during the perinatal period in
mice. Correlation with radio-leukemogenesis. Eur. J. Cancer 11, 65-69 (1975).
3. SIMAR L.J., BONIVER J., CARPENTIER J.-L., BETZ E.H., et J. HAOT: Cytological
and ultrastructural study of the lymphoid-like and x cell population in mouse bone
marrow during the neonatal period. Exp. Hematol. 3, 101-108 (1975).
4. CARPENTIER J.-L., LUYCKX A.S., et P.J. LEFEBVRE: Influence of metformin on
arginine-induced glucagon secretion in human diabetes. Diabète Metabol. 1, 23-28
(1975).
5. CARPENTIER J.-L., PERRELET A., et L. ORCI: Influence of insulin, glucagon and
epinephrine on white adipose cell membranes: a freeze-fracture study. J. Lipid Res. 17,
335-342 (1976).
6. CARPENTIER J.-L., PERRELET A., et L. ORCI: Modifications ultrastructurales de
l'organisation des membranes plasmiques des adipocytes chez les souris obèses
(ob/ob). C.R. Acad. Sci. 283, 1417-1419 (1976).
7. CARPENTIER J.-L., BURY J., LUYCKX A.S., et P.J. LEFEBVRE: Vit. B12 et folic acid
serum levels in diabetics under various therapeutic regimens. Diabète Metabol. 2, 187-
190 (1976).
8. CARPENTIER J.-L., PERRELET A., et L. ORCI: Morphological changes of the adipose
cell plasma membrane during lipolysis. J. Cell Biol. 72, 104-117 (1977).
9. MALAISSE-LAGAE F., CARPENTIER J.-L., PATEL Y.C., MALAISSE W.J., et L. ORCI:
Pancreatic polypeptide: a possible role in the regulation of food intake in the mouse.
Hypothesis. Experientia 33, 915-916 (1977).
10. CARPENTIER J.-L., PERRELET A., et L. ORCI: Perturbation of the adipose cell
plasma membrane in obese (ob/ob) mice. Lab. Invest. 37, 260-264 (1977).
11. CARPENTIER J.-L., MALAISSE-LAGAE F., MULLER W., et L. ORCI: Glucagon
release from rat pancreatic islets: A combined morphological and functional approach.
J. Clin. Invest. 60, 1174-1182 (1977).
12. PASSA P., LUYCKX A.S., CARPENTIER J.-L., LEFEBVRE P.J., et J. CANIVET:
Glucagon secretion in diabetic patients with idiopathic haemochromatosis. Diabetologia
13, 509-513 (1977).
13. CARPENTIER J.-L., GORDEN P., AMHERDT M., VAN OBBERGHEN E., KAHN C.R.,
et L. ORCI: 125
I-insulin binding to cultured human lymphocytes. Initial localization and
fate of hormone determined by quantitative electron microscopic autoradiography. J.
Clin. Invest. 61, 1057-1070 (1978).

6
14. ORCI L., CARPENTIER J.-L., PERRELET A., ANDERSON R.G.W., GOLDSTEIN J.L.,
et M.S. BROWN: Occurrence of low density lipoprotein receptors within large pits on
the surface of human fibroblasts as demonstrated by freeze-etching. Exp. Cell Res.
113, 1-13 (1978).
15. GORDEN P., CARPENTIER J.-L., FREYCHET P., LE CAM A., et L. ORCI: Intracellular
tanslocation of iodine-125-labeled insulin: direct demonstration in isolated hepatocytes.
Science 200, 782-785 (1978) 1
16. GORDEN P., CARPENTIER J.-L., COHEN S., et L. ORCI: Interaction du facteur de
croissance épidermique avec des fibroblastes humains en culture: Une étude
autoradiographique à l'échelon ultrastructural. C.R. Acad. Sci. 286, 1471-1474 (1978).
17. FUKUMA M., CARPENTIER J.-L., ORCI L., GREENE D.A., et A.I. WINEGRAD: An
alteration in internodal myelin membrane structure in large sciatic nerve fibres in rats
with acute streptozotocin diabetes and impaired nerve conduction velocity.
Diabetologia 15, 65-72 (1978).
18. GORDEN P., CARPENTIER J.-L., COHEN S., et L. ORCI: Epidermal growth factor:
morphological demonstration of binding, internalization and lysosomal association in
human fibroblasts. Proc. Natl. Acad. Sci. (USA) 75, 5025-5029 (1978).
19. CARPENTIER J.-L., GORDEN P., FREYCHET P., LE CAM A., et L. ORCI: Lysosomal
association of 125
I-insulin in isolated rat hepatocytes. Direct demonstration by
quantitative electron microscopic autoradiography. J. Clin. Invest. 63, 1249-1261
(1979).
20. CARPENTIER J.-L., GORDEN P., GOLDSTEIN J.L., ANDERSON R.G.W., et L. ORCI:
Binding and internalization of 125
I-LDL in normal and mutant human fibroblasts: A
quantitative autoradiographic study. Exp. Cell Res. 121, 135-142 (1979).
21. CARPENTIER J.-L., GORDEN P., BARAZZONE P., FREYCHET P., LE CAM A., et L.
ORCI: Intracellular localization of 125
I-insulin in hepatocytes from intact rat liver. Proc.
Natl. Acad. Sci. 76, 2803-2807 (1979).
22. CARPENTIER J.-L., GORDEN P., FREYCHET P., LE CAM A., et L. ORCI: 125
I-insulin
is preferentially internalized in regions of the hepatocytes rich in lysosomal and Golgi
structures. Experientia 35, 904-905 (1979).
23. GREENE D.A., WINEGRAD A.I., CARPENTIER J.-L., BROWN M.J., FUKUMA M., et
L. ORCI: Rabbit sciatic nerve fascicle and "endoneurial" preparations for in vitro studies
of peripheral nerve glucose metabolism. J. Neurochem. 33, 1007-1018 (1979).
24. GORDEN P., CARPENTIER J.-L., VAN OBBERGHEN E., BARAZZONE P., ROTH J.,
et L. ORCI: Insulin-induced receptor loss in the cultured human lymphocyte:
Quantitative morphological perturbations in the cell and plasma membrane. J. Cell Sci.
39, 77-88 (1979).
25. CARPENTIER J.-L., GORDEN P., FREYCHET P., LE CAM A., et L. ORCI:
Relationship of binding to internalization of 125
I-insulin in isolated rat hepatocytes.
Diabetologia 17, 379-384 (1979).
26. SCHNEIDER-PICARD G., CARPENTIER J.-L., et L. ORCI: Quantitative evaluation of
gap junctions during development of the brown adipose tissue. J. Lipid Res. 21, 600-
607 (1980).
1
Parmi les 100 articles scientifiques publiés en 1978 qui furent les plus cités en 1979 (Current Contents ISI
1980)

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27. BARAZZONE P., CARPENTIER J.-L., GORDEN P., VAN OBBERGHEN E., et L.
ORCI: Polar redistribution of 125-iodine labeled insulin on the plasma membrane of
cultured human lymphocytes. Nature 286, 401-403 (1980).
28. GORDEN P., CARPENTIER J.-L., FREYCHET P., et L. ORCI: internalization of
polypeptide hormones: mechanism, intracellular localization and significance.
Diabetologia 18, 263-274 (1980).
29. GORDEN P., CARPENTIER J.-L., FREYCHET P., et L. ORCI: Morphologic probes of
polypeptide hormone receptor interactions. J. Histochem. Cytochem. 28, 811-817
(1980).
30. BARAZZONE P., GORDEN P., CARPENTIER J.-L., ORCI L., FREYCHET P., et B.
CANIVET: Binding, internalization, and lysosomal association of 125
I-glucagon in
isolated rat hepatocytes. A quantitative electron microscopic autoradiographic study. J.
Clin. Invest. 66, 1081-1093 (1980).
31. BARAZZONE P., LESNIAK M.A., GORDEN P., VAN OBBERGHEN E., CARPENTIER
J.-L., et L. ORCI: Binding, internalization, and lysosomal association of 125
I-human
growth hormone in cultured human lymphocytes: a quantitative morphological and
biochemical study. J. Cell Biol. 87, 360-369 (1980).
32. CARPENTIER J.-L., HALBAN P.A., RENOLD A.E., et L. ORCI: Internalization of 125
Iinsulin
by IM-9 cultured human lymphocytes: A comparison between A 14 monoiodo
pork and biosynthetic human insulin. Diabetes Care 4, 220-222 (1981).
33. CARPENTIER J.-L., GORDEN P., FREYCHET P., CANIVET B., et L. ORCI: The fate
of ( 125
I)-iodo epidermal growth factor in isolated hepatocytes: a quantitative electron
microscopic autoradiographic study. Endocrinology 109, 768-775 (1981)
34. CARPENTIER J.-L., VAN OBBERGHEN E., GORDEN P., et L. ORCI: Binding,
membrane redistribution, internalization and lysosomal association of 125
I-anti-insulin
receptor antibody in IM-9 cultured human lymphocytes: a comparison with 125
I-insulin.
Exp. Cell Res. 134, 81-92 (1981).
35. HIZUKA N., GORDEN P., LESNIAK M.A., VAN OBBERGHEN E., CARPENTIER J.-L.,
et L. ORCI: Polypeptide hormone degradation and receptor regulation are coupled to
ligand internalization: a direct biochemical and morphologic demonstration. J. Biol.
Chem. 256, 4591-4597 (1981).
36. CARPENTIER J.-L., VAN OBBERGHEN E., GORDEN P., et L. ORCI: Surface
redistribution of 125
I-insulin in cultured human lymphocytes. J. Cell Biol. 91, 17-25
(1981).
37. CANIVET B., GORDEN P., CARPENTIER J.-L., ORCI L., et P. FREYCHET: Glucagon
degradation in isolated rat hepatocytes: effect of ammonium chloride and chloroquine.
Mol. Cell. Endocrinol. 23, 311-320 (1981).
38. FEHLMANN M., CARPENTIER J.-L., LE CAM A., THAMM P., SAUNDERS D.,
BRANDENBURG D., ORCI L., et P. FREYCHET: Biochemical and morphological
evidence that the insulin receptor is internalized with insulin in hepatocytes. J. Cell Biol.
93, 82-87 (1982).
39. GORDEN P., CARPENTIER J.-L., FAN J.Y., et L. ORCI: Receptor mediated
endocytosis of polypeptide hormones: Mechanism and significance. Metabolism 31,
664-669 (1982).

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40. GORDEN P., CARPENTIER J.-L., MOULE M.L., YIP C.C., et L. ORCI: Direct
demonstration of insulin receptor internalization: a quantitative electron microscopic
125
study of covalently bound I-photoreactive insulin incubated with isolated
hepatocytes. Diabetes 31, 659-662 (1982).
41. FEHLMANN M., CARPENTIER J.-L., VAN OBBERGHEN E., FREYCHET P., THAMM
P., SAUNDERS D., BRANDENBURG D., et L. ORCI: Internalized insulin receptors are
recycled to the cell surface in rat hepatocytes. Proc. Natl. Acad. Sci. (USA) 79, 5921-
5925 (1982).
42. HIZUKA N., GORDEN P., LESNIAK M.A., CARPENTIER J.-L., et L. ORCI: Effect of pH
and lysosomotropic agents on membrane associated and internalized 125
I-iodinated
Human Growth Hormone in cultured human lymphocytes: a quantitative biochemical
and electron microscopic study. Endocrinology 111, 1576-1580 (1982).
43. CARPENTIER J.-L., GORDEN P., ANDERSON R.G.W., GOLDSTEIN J.L., BROWN
M.S., COHEN S., et L. ORCI: Colocalization of 125
I-Epidermal Growth Factor and
ferritin low density lipoprotein in coated pits: a quantitative electron microscopic study
in normal and mutant human fibroblasts. J. Cell Biol. 95, 73-77 (1982).
44. CARPENTIER J.-L., FEHLMANN M., FREYCHET P., et L. ORCI: Receptor binding
and internalization of biosynthetic human insulin in isolated rat hepatocytes. Mol. Cell.
Endocrinol. 28, 543-550 (1982).
45. GORDEN P., FREYCHET P., CARPENTIER J.-L., CANIVET B., et L. ORCI: Receptorlinked
degradation of 125
I-insulin is mediated by internalization in isolated rat
hepatocytes. Yale J. Biol. Med. 55, 101-112 (1982).
46. FAN J.Y., CARPENTIER J.-L., GORDEN P., VAN OBBERGHEN E., BLACKETT N.M.,
GRUNFELD C., et L. ORCI: Receptor-mediated endocytosis of insulin. The role of
microvilli, coated pits and coated vesicles. Proc. Natl. Acad. Sci. (USA) 79, 7788-7791
(1982).
47. FAN J.Y., CARPENTIER J.-L., VAN OBBERGHEN E., BLACKETT N.M., GRUNFELD
C., GORDEN P., et L. ORCI: The interaction of 125
I-insulin with cultured 3T3-L1
adipocytes, quantitative analysis by the hypothetical grain method. J. Histochem.
Cytochem. 31, 850-870 (1983).
48. FAN J.Y., CARPENTIER J.-L., VAN OBBERGHEN E., GRUNFELD C., GORDEN P.,
et L. ORCI: Morphological changes of the 3T3-L1 fibroblast plasma membrane upon
differentiation to the adipocyte form. J. Cell Sci. 61, 219-230 (1983).
49. KASUGA M., CARPENTIER J.-L., VAN OBBERGHEN E., ORCI L., et P. GORDEN:
125
I-anti-insulin receptor Fab is internalized by cultured human lymphocytes. Biochem.
Biophys. Res. Commun. 114, 230-233 (1983).
50. FAN J.Y., CARPENTIER J.-L., VAN OBBERGHEN E., GRUNFELD C., GORDEN P.,
et L. ORCI: Surface interaction and intracellular localizations of cationic ferritin:
similarity to 125
I-insulin in 3T3-L1 adipocytes. Eur. J. Cell Biol. 31, 125-131 (1983).
51. ROBERT A., GRUNBERGER G., CARPENTIER J.-L., DAYER J.M., ORCI L., et P.
GORDEN: The insulin receptor of a human monocyte-like cell line; characterization and
function. Endocrinology 114, 247-253 (1984).
52. SCHNEIDER-PICARD G., CARPENTIER J.-L., et L. GIRARDIER: Quantitative
evaluation of Golgi junctions in rat brown adipose tissue after cold acclimatation. J.
Membrane Biol. 78, 85-89 (1984).

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53. CARPENTIER J.-L., DAYER J.M., LANG U., SILVERMANN R., ORCI L., et P.
GORDEN: Down-regulation and recycling of insulin receptors; effects of monensin in
IM-9 lymphocytes and U-937 monocyte-like cells. J. Biol. Chem. 259, 14190-14195
(1984).
54. CARPENTIER J.-L.: Receptor-mediated endocytosis of polypeptide hormones:
mechanism and significance. Mol. Immunol. 21, 1157-1159 (1984).
55. PODSKALNY J.M., TAKEDA S., SILVERMANN R.E., TRAN D., CARPENTIER J.-L.,
ORCI L., et P. GORDEN: Insulin receptors and bioresponses in a human liver cell line
(Hep G.2). Eur. J. Biochem. 150, 401-407 (1985).
56. CARPENTIER J.-L., FEHLMANN M, VAN OBBERGHEN E., GORDEN P., et L. ORCI:
Redistribution of 125
I-insulin in the surface of rat hepatocytes as a function of
dissociation time. Diabetes 24, 1002, 1007 (1985).
57. ROBERT A., CARPENTIER J.-L., VAN OBBERGHEN E., CANIVET B., GORDEN P.,
et L. ORCI: The endosomal compartment of rat hepatocytes: its characterization in the
course of 125
I-insulin internalization. Exp. Cell Res. 159, 113-126 (1985).
58. GRUNBERGER G., ROBERT A., CARPENTIER J.-L., DAYER J.M., ROTH A.,
STEVENSON M.C., ORCI L., et P. GORDEN: Human circulating monocytes internalize
125
I-insulin in a similar fashion to rat hepatocytes: relevance to receptor rgulation in
target and non-target tissues. J. Lab. Clin. Med. 106, 211-217 (1985).
59. CARPENTIER J.-L., BROWN D., IACOPETTA B., et L. ORCI: Detection of surface
bound ligands by freeze-fracture autoradiography. J. Cell Biol. 101, 887-890 (1985).
60. CARPENTIER J.-L., FEHLMANN M., VAN OBBERGHEN E., GORDEN P., et L. ORCI:
Insulin receptors internalization and recycling: mechanism and significance. Biochimie
67, 1143-1145 (1985).
61. CARPENTIER J.-L., GORDEN P., ROBERT A., et L. ORCI: Internalization of
polypeptide hormones and receptor recycling. Experientia 42, 734-744 (1986).
62. CARPENTIER J.-L., GAZZANO H., VAN OBBERGHEN E., FEHLMANN M.,
FREYCHET P., et L. ORCI: Intracellular pathway followed by the insulin receptor
covalently coupled to 125
I-photoreactive insuline during internalization and recycling. J.
Cell Biol. 102, 989-996 (1986).
63. CARPENTIER J.-L., SAWANO F., RAVAZZOLA M., et W.J. MALAISSE: Internalization
of 3
H-glibenclamide in pancreatic islet cells. Diabetologia 29, 259-261 (1986).
64. CARPENTIER J.-L., ROBERT A., GRUNBERGER G., VAN OBBERGHEN E.,
FREYCHET P., ORCI L., et P. GORDEN: Receptor-mediated endocytosis of
polypeptide hormones is a regulated process: inhibition of 125
I-insulin internalization in
hypoinsulinemic diabetes of the rat and man. J. Clin. Endocrinol. and Metab. 63, 151-
155 (1986).
65. CARPENTIER J.-L., REES A.R., GREGORIOU M., KRIS R., SCHLESSINGER J., et L.
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66. IACOPETTA B., CARPENTIER J.-L., POZZAN T., LEW D.P., GORDEN P., et L.
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free calcium and protein kinase C. J. Cell Biol. 103, 851-856 (1986).

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67. VERDIN E., MARATOS-FLIER E., CARPENTIER J.-L., et C.R. KAHN: Persistent
infection with a non-transforming RNA virus leads to impaired growth factor receptors
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68. ILONDO M., COURTOY P.J., GEIGER D., CARPENTIER J.-L., ROUSSEAU G.G., et
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slowly dissociating component of human growth hormone binding and the downregulation
of its receptors, but does not affect insulin receptors. Proc. Natl. Acad. Sci.
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69. CARPENTIER J.-L., GAZZANO H., VAN OBBERGHEN E., FEHLMANN M.,
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70. BANSKOTA N.M., CARPENTIER J.-L., et G.L. KING: Processing and release of
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71. HACHIYA H., CARPENTIER J.-L., et G.L. KING: Differential pathways for insulin and
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72. GRUNBERGER G., IACOPETTA B., CARPENTIER J.-L., et P. GORDEN:
Diacylglycerol modulation of the insulin receptor from cultured human mononuclear
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73. TRAN D., CARPENTIER J.-L., SAWANO F., GORDEN P., et L. ORCI: Ligands
internalized through coated or non-coated invaginations follow a common intracellular
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74. CARPENTIER J.-L., WHITE M.F., ORCI L., et C.R. KAHN: Direct visualization of the
phosphorylated EGF receptor during its internalization in A-431 cells. J. Cell Biol. 105,
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75. GRUNBERGER G., COMI R.J., CARPENTIER J.-L., PODSKALNY J.M., McELDUFF
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76. PACCAUD J.-P., CARPENTIER J.-L., et J.A. SCHIFFERLI: Direct evidence for the
clustered nature of complement receptors type I on the erythrocyte membrane. J.
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77. DALLANEGRA A., SHAFFAR L., BREITTMAYER J.-P., CARPENTIER J.-L., et M.
FEHLMANN: effect of hypertonicity and monensin on CD3/TRC surface expression in
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78. CARPENTIER J.-L., SAWANO F., GEIGER D., GORDEN P., PERRELET A., et L.
ORCI: Potassium depletion and hypertonic medium reduce "non-coated" and clathrincoated
pit formation, as well as endocytosis through these two gates. J. Cell Physiol.
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79. GEIGER D., CARPENTIER J.-L., GORDEN P., et L. ORCI: Down-regulation of insulin
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80. GORDEN P., ARAKAKI R., COLLIER E., et J.-L: CARPENTIER: Biosynthesis and
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81. GRUNBERGER G., GEIGER D., CARPENTIER J.-L., ROBERT A., et P. GORDEN:
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82. CARPENTIER J.-L.: The cell biology of the insulin receptor, Diabetologia, 32, 627-635,
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83. GORDEN D.L., ROBERT A., MONCADA V.Y., TAYLOR S.I., MULHAUSER J., et J.-L.
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84. PACCAUD J.-P., CARPENTIER J.-L., et J.A. SCHIFFERLI: Difference in the clustering
of complement receptor type one (CR1) on polymorphonuclear leukocytes and
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85. JACONI M.E.E., LEW D.P., CARPENTIER J.-L., MAGNUSSON K.E., SJOGEN M., et
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86. ESTREICHER A., MULHAUSER J., CARPENTIER J.-L., ORCI, L. et J.-D. VASSALLI:
The receptor for urokinase-type plasminogen activator polarizes expression of the
protease to the leading edge of migrating cells and promotes degradation of enzymeinhibitors
complexes. J. Cell Biol. 111, 783-792 (1990).
87. PACCAUD J.-P., CARPENTIER J.-L., et SCHIFFERLI J.A.: Exudation induces
clustering of CR1 receptors at the surface of human polymorphonuclear leukocytes.
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88. CARPENTIER J.-L., LEW P.D., GIL R., IACOPETTA B., KAZATCHKINE M.,
STENDAHL O., et T. POZZAN: Internalization pathway of C3b receptors in human
neutrophils and its transmodulation by chemoattractant receptors stimulation. Cell
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89. DE DIEGO J.G., GORDEN P., et J.-L. CARPENTIER: The relationship of ligand
receptor mobility with the internalization of polypeptide hormones and growth factors.
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90. CARPENTIER J.-L., PACCAUD J.-P., GORDEN P., RUTTER W.J., et L. ORCI:
Insulin-induced surface redistribution regulates internalization of the insulin receptor
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91. CARPENTIER J.-L., GORDEN P., et D.P. LEW: Calcium is required for the
intracellular routing of insulin and its receptor. Exp. Cell Res. 198, 144-149 (1992)
92. DE DIEGO J.-L., ROUILLER D., GORDEN P., et J.-L. CARPENTIER: Epidermal
growth factor receptor internalization and biosynthesis in the diabetic rat. Exp. Cell
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93. PACCAUD J.-P., SIDDLE K., et J.-L. CARPENTIER: Internalization of the human
insulin receptor: the insulin-independent pathway. J. Biol. Chem. 267, 13101-13106
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94. PARAVICINI G., COOPER M., FRIEDLI L., SMITH D.J., CARPENTIER J.-L., et M.A.
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95. KRISCHER J., GILBERT A., GORDEN P., et J.-L. CARPENTIER: Endocytosis is
inhibited in hepatocytes from diabetic rats. Diabetes., 42, 1303-1309 (1993).

12
96. CARPENTIER J.-L., PACCAUD J.-P., BACKER J., GILBERT A., ORCI L., et C.R.
KAHN: Two steps of insulin receptor internalization depend on different domains of the
B-subunit. J. Cell Biol., 122, 1243-1252 (1993).
97. NGUYEN T.T., SCIMECA J.-C., FILLOUX C., PERALDI P., CARPENTIER J.-L. et E.
VAN OBBERGHEN: Co-regulation of the mitogen-activated protein kinase,
extracellular signal regulated kinase 1, and the 90 kDa ribosomal S6 kinase in PC12
cells: distinct effects of the neurotropic factor, nerve growth factor, and the mitogenic
factor, epidermal growth factor. J. Biol. Chem., 268, 9803-9810 (1993).
98. COLLIER E., CARPENTIER J.-L., et P. GORDEN: Specific glycosylation of the insulin
receptor is necessary for correct intracellular transport. Biochemistry, 32, 7818-7823
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99. PACCAUD J.-P., REITH W., JOHANSSON B., MAGNUSSON K.-E., MACH B., et J.-L.
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internalization signals and receptor mobility. J. Biol. Chem., 268, 23191-23196 (1993).
100. MARETTE A., KRISCHER J., LAVOIE L., ACKERLEY C., CARPENTIER J.-L., et A.
KLIP: Localization of a1 -and a2-subunits of Na+/K+-ATPase in rat skeletal muscle by
immunoelectron microscopy. Selective recruitment of a2-subunits to the plasma
membrane by insulin. Am. J. Physiol., 265, C1716-C1722 (1993).
101. CARPENTIER J.-L.: The journey of the insulin receptor into the cell: from cellular
biology to pathophysiology. Histochemistry, 100, 169-184 (1993).
102. DE DIEGO J.G., et J.-L. CARPENTIER: Epidermal growth factor content and secretion
by mice submandibular glands is not affected by streptozotocin-diabetes.
Histochemistry, 101, 295-302 (1994).
103. PASCUAL M., STEIGER G., SADALLAH S., PACCAUD J.-P., CARPENTIER J.-L.,
JAMES R., et J.-A. SCHIFFERLI: Identification of membrane-bound CR1 (CD35) in
human urine. Evidence for its release by glomerular podocytes. J. Exp. Med., 179, 889-
899 (1994).
104. LECONTE I., CARPENTIER J.-L., et E. CLAUSER: The functions of the human insulin
receptor are affected in different ways by mutation of each of the four N-glycosylation
sites in the -subunit. J. Biol. Chem., 269, 18062-18071 (1994).
105. STENDAHL O., KRAUSE K.-H., KRISCHER J., JERSTRÖM P., CLARK R.A.,
CARPENTIER J.-L., et D. LEW: Redistribution of intracellular Ca 2+
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106. CARPENTIER J.-L.: Internalization of the insulin receptor: molecular mechanisms and
physiopathological implications. Diabetologia, 37 [Suppl 2], S117-S124 (1994).
107. YAMADA K., GONCALVES E., CARPENTIER J.-L., KAHN C.R., et S. SHOELSON:
Transmembrane domain inversion blocks ER release and insulin receptor signaling.
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108. CARPENTIER J.-L. et D. Mc CLAIN: Insulin receptor kinase activation releases a
constraint immobilizing the receptor on microvilli. J. Biol. Chem., 270, 5001-5006
(1995).

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109. YAMADA K., CARPENTIER J.-L., CHEATHAM B., GONCALVES E., S. SHOELSON et
C.R. KAHN: Role of the transmembrane domain and flanking amino acids in
internalization and down-regulation of the insulin receptor. J. Biol. Chem., 270, 3115-
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110. LAVOIE L., ROY D., RAMLAL T., DOMBROWSKI L., MARTIN-VASALLO P.,
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of α2 and β1 subunits of the Na + -K + -ATPase of the plasma membrane induced by
insulin. Am. J. Physiol. 270, C1421-C1429 (1996).
111. RASMUSSON B. J., CARPENTIER J.-L., PACCAUD J.-P., et K.-E. MAGNUSSON:
The N-Formyl methionyl peptide, formyl-methionyl-leucyl phenylalanine (fMLP)
increases the lateral diffusion of complement receptor 1 (CR1, CD 35) in human
neutrophils; a causative role for oxydative metabolites?. Bioscience Reports, 16, 391-
404 (1996).
112. PACCAUD J.-P., REITH W., CARPENTIER J.-L., RAVAZZOLLA M., AMHERDT M.,
SCHEKMAN R., et L. ORCI: Cloning and functionnal characterization of human
homologues of COPII component Sec23. Mol. Biol. Cell., 7, 1535-1546 (1996).
113. FOTI M., CARPENTIER J.-L., AIKEN C., TRONO D., LEW D.P., et K.H. KRAUSE:
Second-messenger-mediated exclusion from clathrin-coated pits: a novel and selective
mechanism in the control of CD4 endocytosis. Mol. Biol. Cell, 8, 1377-1389 (1997).
114. MANGASARIAN A., FOTI M., AIKEN C., CHIN D., CARPENTIER J.-L.., et D. TRONO:
The HIV-1 nef protein acts as a connector with sorting pathways in the Golgi and at the
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115. FOTI M., MANGASARIAN A., PIGUET V., LEW D.P., KRAUSE K.H., TRONO D., et J.-
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116. GILBERT A., PACCAUD J.-P. et J.-L. CARPENTIER: Direct measure of clathrincoated
vesicle formation by a cell-free assay. J. Cell Sci., 110, 3105-3115 (1997).
117. HAMER I., RENFREW HAFT C., PACCAUD J.-P., MAEDER C., TAYLOR S., et J.-L.
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118. HAMER I., PACCAUD J.-P., BELIN D., MAEDER C., et J.-L. CARPENTIER: The
soluble form of the complement C3b/C4b receptor (CR1) results from a proteolytic
cleavage in the C-terminal region of the CR1 transmembrane domain. Biochem. J.,
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119. MAGGI D., ANDRAGHETTI G., CARPENTIER J.-L., et R. CORDERA: Cysteine 860 in
the insulin receptor is required for internalization and signal transduction.
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120. RENFREW HAFT C., deLA LUZ SIERRA M., HAMER I., CARPENTIER J.-L., et S.I.
TAYLOR: Analysis of the juxtamembrane dileucine motif in the insulin receptor.
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121. PIGUET V., CHEN Y.-L., MANGASARIAN A., CARPENTIER J.-L., et D. TRONO: Nef
downregulates MHCI and CD4 by connecting these receptors with the μ chain of
adaptor complexes. EMBO J., 17, 2472-2481 (1998)

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122. POUSSIN C., FOTI M., CARPENTIER J.-L., et J. PUGIN: CD14-dependent endotoxin
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123. GILBERT A., PACCAUD J.-P. et J.-L. CARPENTIER: Direct evidence of the
endocytotic function of caveolae by a cell-free assay. J. Cell Sci., 112, 1101-1110
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and D. TRONO: Nef-induced CD4 degradation: a diacidic-based motif in Nef functions
as a lysosomal targeting signal through the binding of -COP in endosomes. Cell, 97,
63-73 (1999).
125. PAGANO A., LETOURNEUR F., GARCIA-ESTEFANIA D., CARPENTIER J.-L., ORCI
L. and J.-P. PACCAUD: A family of Sec24-related proteins is implicated in protein
sorting at the endoplasmic reticulum. J. Biol. Chem., 274, 7833-7840 (1999).
126. FOTI M., CARTIER L., PIGUET V., LEW D.P., CARPENTIER J.-L., TRONO D., and
K.H. KRAUSE: The HIV Nef protein alters Ca 2+ signaling in myelomonocytic cells
through SH3-mediated protein-protein interactions. J. Biol. Chem., 274, 34765-34772
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127. GONIN S., DESCHENE G., ROGER F., BENS M., MARTIN P.-Y., CARPENTIER J.-L.,
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128. HAMER I., FOTI M., EMKEY R., PHILIPPE J., MAEDER C., KAHN C.R., and J.-L.
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with severe insulin resistance inhibits receptor internalization but preserves signaling
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129. FOTI M., PHELOUZAT M.-A., RASMUSSON B., MAGNUSSON K.-E., and J.-L.
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130. SHACKLETON S., HAMER I., FOTI M., ZUMWALD N., MAEDER C. and J.-L.
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131. IKOMOV OC, SBRISSA D, FOTI M, CARPENTIER JL, and A. SHISHEVA: PIKfyve
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132. DUDOGNON P., MAEDER-GARAVAGLIA C., CARPENTIER J.-L., and J.-P.
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133. HEZAREH M., MOUKIL M.A., SZANTO I., PONDARZEWSKI, MOUCHE S., M.,
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135. FOTI M., PORCHERON G., FOURNIER M. and J.-L. CARPENTIER The necks of
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glucagon release in vitro: an unsettled controversy. In: Current views on hypoglycemia
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140. CARPENTIER J.-L., GORDEN P., FREYCHET P., et L. ORCI: Aspects
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147. FEHLMANN M., CARPENTIER J.-L., VAN OBBERGHEN E., BRANDENBURG D.,
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148. HIZUKA N., GORDEN P., CARPENTIER J.-L., LESNIAK M.A., ORCI L., et K.
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160. CARPENTIER J.-L et J.-P. PACCAUD: Molecular and cellular biology of insulin
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