LUIS C. AFONSO. MD. FACC. Assistant Professor, Clinician ...

LUIS C. AFONSO. MD. FACC.
Assistant Professor, Clinician- Educator Track,
Internal Medicine, Division of Cardiology,
Wayne State University, Detroit, MI
Professional Address: Harper University Hospital, 8 Brush, Division of Cardiology 3990 John R. Detroit, MI,
48201
Work: 313-745-2620
Fax: 313-993-8627
Pager: 313-745-3064
E-mail: lafonso@med.wayne.edu
EDUCATION
1980 - 1984 MBBS Degree, Goa Medical College, University of Bombay, India
PROFESSIONAL TRAINING
1997-2000 Fellowship in Cardiology, Wayne State University Affiliated Hospitals,
Detroit, MI
1996 - 1997 Fellowship in Geriatrics, Wayne State University Affiliated Hospitals,
Detroit, MI.
1993 - 1996 Residency Internal Medicine, Wayne State University Affiliated Hospitals, Detroit, MI
1989 -1993 Senior Residency Internal Medicine, Goa Medical College Affiliated Hospitals, University of
Bombay, India
1986 - 1989 Junior Residency Internal Medicine, Goa Medical College Affiliated Hospitals, University of
Bombay, India
1984 - 1986 Rotating Internship, Goa Medical College Affiliated Hospitals, University of Bombay, India
FACULTY APPOINTMENTS
2002 - Present Program Director, Cardiology Fellowship Training Program, Wayne State University
2001 - Present Assistant Professor, Internal Medicine-Cardiology, Wayne State
University, Detroit Medical Center
HOSPITAL APPOINTMENTS
2004-present Director, Echocardiography Laboratory, Harper University Hospital
2002- Present Consultant Cardiologist, Renal and Pancreatic Transplant Service,
Detroit Medical Center
2001- 2004 Director Echocardiography Laboratory, John D Dingell VA Medical
Center, Detroit, MI
PROFESSIONAL MEMBERSHIPS
Member, American Heart Association
Member, American College of Cardiology
Member, American Society of Echocardiography
Associate, American College of Physicians
Member, American Medical Association
LICENSURE AND BOARD CERTIFICATION

MEDICAL LICENSURE
DEA License 2002 (Active)
State of Michigan: Permanent Physician License # 4301062290 (Active)
Controlled Substance License # 4301062290 (Active)
CERTIFICATION
2007 Level II Cardiac Computerized Tomographic Angiography (CCTA)
2003 Testamur, Board Certification, American Society of Echocardiography
2002 Radiation Physics Course (200 hrs), requirement by Nuclear Regulatory
Commission for NRC licensure
2000 Certified American Board of Internal Medicine, Cardiovascular Diseases
1998 Certified American Board of Internal Medicine, Special Qualification
Geriatric Medicine
1996 Certified American Board of Internal Medicine
1993 Foreign Medical Graduate Exams in the Medical Sciences
FMGEMS I (Basic Sciences)
1993 Federal Licensing Examination (FLEX Components I & II)
1992 FMGEMS II (Clinical Sciences)
1989 Postgraduate MD Degree Internal Medicine, University of Bombay, India
1984 MB.BS Degree, University of Bombay, India
HONORS AND AWARDS
2006 “School of Medicine Teaching Award”, Wayne State University, School of Medicine, MI
2005 “Academic Teacher of the Year” award 2004-05. Division of Cardiology, Wayne State
University
2000 Abstract selected for the “Young Investigator Award” Competition of the American Society of
Nuclear Medicine Annual Meeting, June 2000
1999 “ Best Teaching Fellow Award” selected by Residents in the Internal Medicine Residency
Program, Wayne State University Affiliated Hospitals, Detroit, MI 1999 – 2000. Chief Fellow,
Division of Cardiology, Wayne State University Affiliated Hospitals, Detroit, MI
1998 Award Winner, American College of Cardiology, Michigan Chapter, Clinical Vignette,
Competition, fall 1998
1997 ”Outstanding Fellow of the Year” award, Division of Cardiology, Wayne State University,
Detroit Medical Center, Detroit, MI
1989 Ranked First in Class of 1989, M.D. Degree Exam. Goa Medical College, University
of Bombay.
1984 Ranked First in MBBS Class of 1984 and Second in Internal Medicine, University
of Bombay.
PUBLICATIONS
1. Afonso L, Mahajan N. Single Photon Emission Computed Tomography (SPECT)
Myocardial Perfusion Imaging (MPI) in the Diagnosis of Left Main Disease Accepted for publication
Aug 25, 2008 Clinical Cardiology.CLC-08-0312. 2008.
2. Afonso L, Bernal J, Bax J, Abraham TP. The Echocardiographic Assessment of Hypertrophic
Cardiomyopathy: Emphasis on Novel imaging Modalities. J Am Coll Cardiol Img, 2008; 1:787-800.
3. Mahajan N, Khetarpal V, and Afonso L. Stroke secondary to calcific bicuspid aortic valve: Case
report and literature review. Accepted to Journal of Cardiology. JJCC-D-08-00094R1, Nov 2008

4. Mahajan N, Afonso L. Right Ventricular Extension of Inferior Wall Myocardial Infarction: Role
of Right Sided Electrocardiogram. South Med J. 2008 Nov 11. Ahead of print.
5. Bachour K , Zmily H, Kizilbash M , Awad K, Hourani R, Hammad H, Sobel JD, Ghali JK, Levine
D, Afonso L. Significance of Valvular Perforation in Left-Sided Infective Endocarditis.MS # CLC-
08-0246.R1. Accepted Jun 11, 2008. Clin Cardiology 2008
6. Kondur A K, Li T, Vaitkevicius P, Afonso L. Quantification of Myocardial Iron Overload by
Cardiovascular Magnetic Resonance Imaging and Review of the Literature. Clinical Cardiology
2008 April 15, Ahead of print.
7. Nelson K, Li T, Afonso L. Diagnostic Approach and Role of MRI in the Assessment of Myocarditis.
Accepted for publication. Cardiology In Review. MS #CIR-04-206R1
8. Mohamad T, Kondur A, Vaitkevicius P , Bachour K, Thatai D, Afonso L. Cocaine Induced Chest
Pain and Beta Blockade: An inner city experience. Accepted for publication American J
Therapeutics . Manuscript Number: AJT-20082343
9. Afonso L, Khaled B, Khaled A. Tako-tsubo Cardiomyopathy: Pathogenetic Insights and Myocardial
Perfusion Kinetics Using Myocardial Contrast Echocardiography Eur J Echocardiogr. 2008
Nov;9(6):849-54. Epub 2008 Jun 20
10. Pradhan J, Vankayala H, Niraj A,, Kumaravelu P, Trivedi, M, Thatai D, Afonso L .QT Dispersion at
Rest and During Adenosine Stress Myocardial Perfusion Imaging Correlation with Myocardial
Jeopardy Score. Clin Cardiol. 2008 May;31(5):205-10.( Contributed to concept, design and
discussion in manuscript)
11. Pradhan J, Schreiber T, Niraj A, Veeranna V, Ramesh K, Saigh L, Afonso L
Comparison of Five-Year Outcome in African Americans versus Caucasians Following
Percutaneous Coronary intervention. Catheter Cardiovasc Interv. 2008 Jul 1;72(1):36-44
12. Afonso L, Kottam A, Khetarpal V. "Myocardial Cleft, Crypt, Diverticulum or Aneurysm ? Does it
really matter?" Clinical Cardiology. Accepted for publication ID CLC-08-0096 (first description of
congenital cleft with echocardiography in the literature)
13. Kondur A K, Afonso L, Berenbom LD, Lakkireddy DR Implantable cardioverter defibrillators save
lives from lightning-related electrocution too! Pacing Clin Electrophysiology. 2008 Feb;31(2):256-7
14. Pitta SR, Kondur AK, Afonso L. Quadricuspid Aortic Valve associated with Unruptured Sinus of
Valsalva Aneurysm Eur J Echocardiogr. 2008 Jul;9(4):575-6. Epub 2008 Feb 19
15. Kondur A, Pitta SR, Afonso L. Incremental Utility of Real-time Three Dimensional
Echocardiography in the Diagnosis and Preoperative Assessment of Cleft Mitral Valve in Adults.
Eur J Echocardiogr. 2008 Jul;9(4):586-8. Epub 2008 Mar 5
16. Afonso L, Niraj A, Pradhan J, Veeranna V, Fakhry H , Pradhan J. Ethnic and Gender
Differences in Disease Burden in Patients Undergoing Coronary Angiography: The Confounding
Influence of Obesity. Ethn Dis. 2008 Winter;18(1):53-8
17. Afonso L, Mohamad T, Thatai D. Crack Whips the Heart: A Comprehensive Review of the
Cardiovascular Toxicity of Cocaine. Am J Cardiol. 2007 Sep 15;100(6):1040-3.
18. Terefe YG, Niraj A, Pradhan J, Kondur A, Afonso L. Myocardial Infarction with Angiographically
Normal Coronary Arteries in The Contemporary Era. Coron Artery Dis. 2007 Dec;18 (8):621-6.
19. Niraj A, Pradhan J, Veeranna V, Fakhry H, Afonso L. Severity of coronary artery disease in
obese patients undergoing coronary angiography: "Obesity Paradox" revisited. Clin Cardiol. 2007
Aug;30(8):391-6
20. Pradhan J, Niraj A, Afonso L. Determinants of Amount of Contrast Utilized In Patients Undergoing
Percutaneous Coronary Procedures. Coron Artery Dis. 2007 Jun;18(4):275-82.
21. Pitta SR, Kondur A, Afonso L. Metastatic Extracavitary Cardiac Melanoma: The Role of
Contemporary Imaging Techniques in Diagnosis and Surgical Planning. Circulation. 2007 Apr

24;115(16):e415-7. (novel application of perfusion imaging during transesophageal
echocardiography)
22. Pitta S, Thatai D, Afonso L Thromboembolic Complications of Left Ventricular Noncompaction –
Case Report and Brief Review of the Literature. J Clin Ultrasound. 2007 May 7;35(8):465-468
23. Dandapantula HK, Afonso L, Katkuri H, Chandu L, Spears JR . Unexplained pulmonary
hypertension in elderly patients: role of heart failure with normal ejection fraction, Bernheim effect,
and reverse Bernheim effect. Chest. 2007 Jun;131(6):1987-8;
24. Dandapantula HK, Spears JR, Chandu L, Katkuri H, Afonso L Cigarette smoking and
myocardial infarction in young men and women - "Let us not forget coronary vasospasm" Int J
Cardiol. 2007 Jun 25 PMID: 17594910
25. Jin H, Afonso L, Singh A, Migdal S, Spears JR. Recurrent heart failure with preserved ejection
fraction but markedly elevated BNP in a 51-year-old female on hemodialysis with oversized AV
fistula. International J Cardiol. 2006 Jun 28;110(3):429-30.
26. Reddy M, Thatai D, Bernal J, Afonso L. Apical Hypertrophic Cardiomyopathy: Potential Utility of
strain Imaging in Diagnosis. Eur J Echocardiogr. 2007 Mar 27 ( novel application of 2 D strain or
speckle tracking imaging)
27. Penugonda N, Afonso L, Complex Endocarditis in an Immunocompromised Host: The Role of 3-
Dimensional Echocardiography J Am Soc Echocardiogr. 2007 Nov;20(11):1314.e9-11.
28. Modi S, Koul D, Afonso L. Unusual Pulmonary Venous Flow Profile in a Patient with Mitral Valve
Perforation secondary to Bacterial Endocarditis. Echocardiography. 2006 Feb;23(2):137-9.
29. Bernal J, Pradhan J, Tchokonte R, Li T, Afonso L . Acute Pulmonary Edema Following
Pericardiocentesis For Cardiac Tamponade, Can J Cardiol. 2007 Dec;23(14):1155-6.
30. Lakireddy DR, Li T, Afonso L, Kondur AK. Is Acute Back Pain a Warning Sign for Penetrating
Atherosclerotic Ulcer? (in press) , American Journal Medicine, 2007
31. Di Carli M, Afonso L, Campisi R, Ramappa P, Bianco- Battles D, Grunberger G, Schelbert H.
Coronary vascular dysfunction in premenopausal women with diabetes mellitus. American Heart
Journal 2002;144:711- 718 (actively involved in conceptualizing, designing and data collection)
32. Afonso LC, Edelson GW, Sowers JR. Metabolic abnormalities in Hypertension. Current Opinion
in Nephrology and Hypertension.1997; 6:219-223.
33. Sowers JR, Raman BB, Afonso LC, Bedford-Rice K, Standley PR. Effects of Antihypertensive
Therapy on Platelet Cytosolic Calcium Responses to Low density Lipoprotein Cholesterol. Journal
of Human Hypertension 1996; 10:177-180.(contributed to key elements in study relating to platelet
calcium assays)
34. Afonso L, J Dihenkar, GJ Alangaden. Leptospirosis: Unusual cause of Fever, Jaundice and Renal
Failure. Infectious Diseases in Clinical Practice.1997;6(3):203-205.
35. Afonso L, Sowers JR. Effect of advancing age on cardiovascular baroreflex function Proceedings
of the 3rd International Congress of Hypertension in the Elderly, Feb.1995:95-107.
ABSTRACTS /POSTERS AND PRESENTATIONS
1. Kondur A, Jacob S, Niraj A, Pradhan J, Sandidge G, Afonso L. Pattern and Extent of Systolic
Intraventricular Dyssynchrony in Patients with Hypertrophic Cardiomyopathy: Comparison with
Hypertensive and Athlete Hearts Using Tissue Doppler Imaging. Selected Oral e-presentation
American Heart Association. Scientific Sessions. Abst#1061 .Nov 2008. New Orleans
2. Mahajan N, Mahavan R, Chaturvedi S, Afonso L .Predictors of Stroke in Patients with Low
ejection fraction and Sinus Rhythm: Left Ventricular Non Compaction is a risk factor. American
Heart Association's International Stroke Conference 2009 to be held on Feb 18-20 at San

Diego, CA.
3. Afonso L, Mahajan N, Prigent F. Spectrum of Gated SPECT Myocardial Perfusion Imaging (MPI)
Abnormalities in Patients with Left Main Coronary Artery Disease: A Tertiary Medical Center
Experience.” Journal of Nuclear Cardiology; Volume 15, Number 4;S25-31July/August 2008.
Annual American Society of Nuclear Cardiology Scientific Session ASNC Sep 2008
4. Mathew A, Bhandare D, Kizibash M, Afonso L Tei Index and Spectrum of Diastolic Abnormalities
in Takotsubo Cardiomyopathy 14th World Congress on Heart Disease.The International Congress
on Heart Disease Annual Scientific Sessionsm, Toronto, July 2008
5. Kondur AK, Niraj A, Afonso L. Systolic Intraventricular Dyssynchrony in Hypertrophic
Cardiomyopathy: Differentiation from Athlete Heart 14th World Congress on Heart Disease.The
International Congress on Heart Disease Annual Scientific Sessionsm, Toronto, July 2008
6. Veeranna V, Niraj A, Pradhan J, Afonso L. Do Traditional Cardiovascular Risk Factors Predict
Extent of Angiographic Stenosis in Elderly Patients 14th World Congress on Heart Disease.The
International Congress on Heart Disease Annual Scientific Sessions Toronto, July 2008
7. Niraj A, Pradhan J, Veeranna V, Afonso L. Racial Disparities in Coronary Angiographyand
Noninvasive Testing: Myth or Reality. 14th World Congress on Heart Disease.The International
Congress on Heart Disease Annual Scientific Sessions 2008
8. Bandaru H, Mohammed K, Jareer F, Afonso L. Predictors of Cardiac Troponin-I Release in
Patients with Hypertensive Emergency. XIVth Scientific Sessions of the Inter-American Society
fore Hypertension (IASH) and the Consortium for Southeastern Hypertension Control, May 2007
9. Hanson ID, Venkalaya H, Mohamad T, Afonso L. Comparison of Two-Dimensional versus Three-
Dimensional Echocardiography Techniques to Measure Left Atrial Volume: Correlation with Left
Ventricular Filling Pressure. Journal American Society Echocardiography Vol 20(5):567, May, 2007
10. Hourani R, I Hanson ID , Afonso L. Do Mitral Annular and Inflow Velocities Correlate with Indices
of Left Atrial Mechanical Function Derived Volumetrically by 3-Dimensional Echo? Journal
American Society Echocardiography Vol 20(5): 611, May 2007
11. Terefe Y, J Pradhan J, Afonso L. Myocardial Infarction with Angiographically Normal Coronary
Arteries. Catheter Cardiovasc Interv Vol 2007 May 1;69(6):S69.
12. Pradhan J, Veerana V, Niraj A, Ramesh K, Afonso L, Schreiber TL. Racial Differences in
Outcome After Percutaneous Intervention: A Five-Year Follow up. Catheter Cardiovasc Interv.
2007 May 1;69(6):S75-76.
13. Rodrigues D, Pitta SR, Afonso L. Submassive Pulmonary Embolism : To Lyse or not to Lyse ?
Shortlisted for oral presentation 30th Annual Society for General Internal Medicine Scientific
Sessions , April 2007, Toronto, Canada
14. Niraj A, Pradhan J, Veeranna V, Fakhry H , Afonso L. Severity of Coronary Artery Disease in
Obese Patients Undergoing Coronary Angiography and Intervention: “Obesity Paradox” Revisited J
Am Coll Cardiol. 2007 March 6 Supplement 1;49(9):A212-13.
15. Bandaru H, Mohammed K, Jareer F, Afonso L. Clinical Predictors of Myonecrosis in Patients
Presenting with Hypertensive Emergencies Selected by the Abstract Review Board for
presentation as a poster finalist for the ACP Research Poster Competition ,Internal Medicine 2007
Scientific Sessions in San Diego, April 19, 2007 San Diego .
16. Cardozo L, Afonso L Steinberg J, Vaitkevicius P, Brown G, Checcobelli The Value of Case
Managed Tele Homecare(CMTH)in Recently Discharged Elderly Patients Journal of the American
Geriatrics Society, Volume 55, Issue s1, Page S1-S218,D-129, Apr 2007.Shortlisted for the
Presidential poster session(top 25 % abstracts)
17. Kondur AK, Afonso L, Vaka S, Stauffer N, Parker D, Kreighbaum K BerenbomLD, Pimentel R ,
Emert E, Lakkireddy DR. Implantable Cardioverter Defibrillators Save Lives from Lightening

Related Electrocution too..! 28th Annual Scientific sessions of the Heart Rhythm Society, May
2007, Denver CO.
18. Bachour K, Awad K, Afonso L . Predictors of Valve Perforation and Mortality in Infective
Endocarditis. Valvular Heart Disease : New Strategies, Mayo Clinic, Las Vegas May 2006
19. Pradhan J, Hui Jin, Afonso L Global and Regional Contractile Abnormalities in Patients with Wolff-
Parkinson- White Syndrome Using Speckle Tracking Imaging. ACC Michigan Chapter Annual
Scientific Sessions Oct 2006
20. Pradhan J, Niraj A, Afonso L. Determinants of Amount of Contrast Utilized In Patients Undergoing
Percutaneous Coronary Procedures Catheter Cardiovasc Interv 2006;67(5):812-813.
21. Mohamad T, Vaitkevicius P, Bachour K, Ibrahim M, Higassy H, Agha SD, Afonso L. Cocaine-
Related Chest Pain- Utility of TIMI-Risk Stratification and Effects of Beta Blockers on Outcome.
Supplement Journal American Coll Card, JACC 47 (4): 288A. Feb 2006
22. Modi S, Kronenberg M, Afonso L, Chaturvedi S. Gender, Carotid Stenosis And Risk Factor
Treatment In African American Patients with CAD. Second International Conference on Women,
Heart Disease and Stroke. American Heart Association. 2005
23. Walsh MF, Xu R, Afonso L, Skafar D, Ram J, Sowers JR. Insulin and IGF-1 mediated vascular
involves both endothelial and vascular smooth muscle nitric oxide. 79th Annual Meeting of the
Endocrine Society.
24. Afonso L, Ramappa P, Blanco-Battles B, Di Carli M. Loss of Cardioprotection in Premenopausal
Women with Diabetes Mellitus. Oral presentation at the Annual Meeting of American Society of
Nuclear Medicine, St Louis, Missouri, June 2000.
25. Veerapan B, Ramappa P, Gowda S, Afonso L, Otto M, Di Carli MF. Are Cardiac symptoms
Predictive of Clinical Outcomes in patients with Cardiomyopathy Undergoing Revascularization.
Presented at Annual Meeting of the American Society of Nuclear Medicine Meeting, Missouri,
June 2000.
26. Di Carli MF, Afonso L, Roxanna Campisi, Ramappa P, Bianco Battles D, Grunberger G,
Schelbert H. Coronary Vascular Dysfunction in Premenopausal Women: A mechanism for loss of
gender differential ? Circulation 2000; 102(18) II-544.
27. Pitta SR, Kumaravelu P, Afonso L - Unusual Physical Examination and Unusual Diagnosis: Rare
case of Aortic arch and Left Brachiocephalic Vein fistula. - Case Study Published in Cardiosource,
American College of Cardiology, November 22, 2006.
28. Bachour K, Awad K , Afonso L. Midventricular Ballooning Cardiomyopathy: Epicardial spasm vs.
Microvascular Dysfunction; Can Echo Identify the Culprit ?” Second annual Cases Competition at
the 18th Annual Scientific Sessions of the American Society of Echocardiography (ASE). Seattle,
WA ,June 16-20, 2007.
29. Kondur A, Afonso L " Implantable Cardioverter Defibrillators Save Lives from Lightening Related
Electrocution too..! " PACE MS # PACE-07-0190"
30. Kondur A, Pitta SR , Afonso L. Cleft Mitral valve in Adults; The role of 3D Echo in diagnosis and
surgical planning. Valves in the Heart of the Big Apple V, April 12-14, 2007, NYC.
31. Pitta SR , Penugonda, Afonso L , Thatai D. A combination of pulmonary valve and pulmonary
artery stenosis in an adult with corrected Tetralogy of Fallot . Valves in the Heart of the Big Apple
V, April 12-14, 2007, NYC.
32. Rudraiah L, Dhabuwala J, Awad K, Afonso L Dobutamine Induced Coronary Artery Spasm
Presenting AS ST Elevation During Stress Echo with Normal Coronaries on Angiogram. MD.
Annual Scientific Sessions Michigan ACC Chapter 2006
33. Pitta SR, Vaitkevicius P, Afonso L. Extensive Circumferential Aortic Intramural Hematoma Treated
with Endovascular Stenting Case of the week, Nov 20, 2006 TCTMD-The comprehensive

Cardiology and Interventional Resource, 2006
34. Penugonda N, Afonso L. Complex Endocarditis in an Immunocompromised Host . Second Annual
American Medical Association Resident, Fellow and Student (AMA-RFS) Research Poster
Symposium Dallas, Texas, November 2005
35. Pitta SR, Afonso L, Noncompaction with the Left Ventricular Myocardium with Mitral Valve
prolapse and AV Block. ACC Michigan Chapter, Feb 2005.
36. Pitta S, Elder M, Afonso L. Quadricuspid Aortic Valve associated with Unruptured Sinus of
Valsalva Aneurysm. Valves in the Heart of the Big Apple IV: Evaluation and Management of
Valvular Heart Diseases 2005.
37. Povalaram SR, Guglin M, Afonso L. Hiatal Hernia Presenting as Recurrent Syncope. Oral
presentation , Society of General Internal Medicine, 2005 Midwest Regional Meeting 2005,
Chicago, Illinois.
38. Pitta S R, Kalra N, Meri A, Afonso L. Misdiagnosis of Critical mitral Stenosis- Poster presentation
ACP-ASIM Michigan Scientific Chapter, MI -2003.
39. Extensive Circumferential Aortic Intramura Hematoma Treated with Endovascular Stenting
Afonso L, Pitta S, Vaitkevicius P www.tctmd.com Nov 2006
40. Pitta SR, Afonso L. Left-ventricular Noncompaction .Oral presentation ACC Michigan Chapter, MI-
2004
41. Luis Afonso, G .Ayer, L. Cardozo. Immediate Pressure Urticaria as a Complication of Sensory
Pin-Prick Testing. Dept of Internal Medicine Wayne State University Detroit,MI, presented at the
ACP, Michigan Chapter Meeting, and Sept 1994.
42. Afonso L, Arabi Y, Brown P Vertebral Osteomyelitis due to Aspergillus Fumigatus. Wayne State
University, Detroit, MI. May 1995 ACP Michigan Chapter.
43. Billakanty S, Afonso L An Unusual Complication Following Cocaine Use. Clinical Vignette
Competition, Regional Michigan Chapter ACC sessions, 2002
44. Afonso L. A rare form of left to right shunt: Acquired Gerbodie Ventricular Septal Defect. Award
Winner, American College of Cardiology, Michigan , Chapter, Clinical Vignette, Competition, Fall
1998.
ONLINE PUBLICATIONS AND BOOK CHAPTERS
1. Afonso L. Mohamad T, Badheka A. Cardiotoxicity associated with drugs of abuse in
Cardiovascular Toxicology,” 2nd Edition . Volume 6 of the Comprehensive Toxicology series .
Elsevier. 2008.
2. Afonso L and Bachour: Chapter "Assessment of LV Size and Mass" Springer. Handbook of
Echocardiography. *The Experts Pocket Guide to Echocardiography: The Experts Handbook of
Echocardiography**A case based approach to bedside echocardiography*The Echo Pocket Guide
3. Afonso L, Mengistu S. Approach to Pericardial Diseases Springer. Handbook of
Echocardiography. *The Experts Pocket Guide to Echocardiography: The Experts Handbook of
Echocardiography**A case based approach to bedside echocardiography*The Echo Pocket Guide
4. Afonso L, Bernal J. Echocardiography in Hypertrophic Cardiomyopathy Springer. Handbook of
Echocardiography. *The Experts Pocket Guide to Echocardiography: The Experts Handbook of
Echocardiography**A case based approach to bedside echocardiography*The Echo Pocket Guide
5. Mitral Regurgitation. Hanson I, Afonso L .E-medicine 2008. www.emedicine.com
6. Arrhythmic and Mechanical complications of Acute Myocardial Infarction. A review. A. Kondur AK,
Daram D, Afonso L . E-medicine 2006. www.emedicine.com
7. Primary and Secondary Prevention of Coronary Artery Disease. Mohammed T, Ramappa P,
Afonso L. E-medicine 2006. www.emedicine.com

8. Pitta S, Kumaravelu P, Afonso L. 44-Year-Old Male With Heart Failure and Continuous Murmur.
Online Case studies. Cardiosource issue 11/22/2006 @
http://www.cardiosource.com/casestudies/casestudy. (American College of Cardiology). CME Term
of Approval: 11/22/2009 The American College of Cardiology Foundation designates this
educational activity for a maximum of 0.25 AMA PRA Category 1 Credit(s)TM
9. Afonso L and Di Carli MF. Coronary Flow Regulation in Diabetes. Lanzer P and Topol
E J. Theory and Practice of Vascular Medicine;1st ed. Springer Verlag 2002.
10. Kleerekoper K, Hisham Alrefai, Afonso L, Raman BB” Metabolic bone disease” in
Challenging Cases in Endocrinology. Humana Press 2002
INVITED LECTURES
1. Strain Imaging: Principles to Practice. Michigan Society of Echocardiography, Annual scientific
sessions , Crystal Mountain, MI , Feb 8th 2009
2. Current Status of 3D-Echocardiography: Overview with Illustrative Examples Michigan Society of
Echocardiography, Annual scientific sessions , Crystal Mountain, MI , Feb 8th 2009
3. Peripartum Cardiomyopathy: Focus on Etiopathogenesis and Diagnosis. Perinatology Research
Branch, National Instititute of Health, Harper University Hospital, Michigan, Aug 2008
4. “Giant Lambl’s Excrescences” as a cause of Cryptogenic Stroke ; Invited Expert Discussant CPC
February 2008 Wayne State University
5. Cardiac Resynchronization Therapy. Pathophysiologic insights and Identification of responders.
Congestive Heart Failure. New Frontiers in Cardiology. 2nd Annual Conference organized by
Providence Hospital, Westin Hotel, Southfield Michigan Sept 21st 2006.
6. Recent Advances in Echocardiography. Medical Grand Rounds, Nov 15, 2006. Scott Hall, Wayne
State University.
7. Update on ECG Interpretation, (Clinical Skills Development Session). Michigan Chapter, American
College of Physicians, Scientific Meeting, Sep 2005. Also served as judge for Poster Competition,
Michigan Chapter, and American College of Physicians, Scientific Meeting, and Sep 2005.
8. Diastolic Heart Failure: Feeling or Filling out of Sorts. Michigan Chapter. American College of
Cardiology. Scientific Meeting, Oct 2005, Traverse City, Michigan
9. Tissue Doppler Imaging : Contemporary Applications, Invited lecture to Echo Section of the
Perinatology Research Branch, NIH, WSU. 2005
10. Invited Expert: Michigan Society of Echo, Stump the Stars Regional Chapter Meeting, Aug 2005
JOURNAL REVIEWER/ REFEREEING RESPONSIBILITIES
2007: Circulation (1 manuscript)
2007: American Journal Cardiology (8 manuscripts)
2006 - present- Clinical Cardiology (15 manuscripts)
2005 - present: Chest ( 2 manuscripts)
2005 Annual Meeting .Abstract Reviewer. Michigan Chapter, American College
of Physicians, Scientific Meeting, Sep 2005
2005 Annual scientific Sessions: Abstract Reviewer. American College of Cardiology,
Michigan Chapter. Oct 2005
ONGOING RESEARCH : DATA BASE STUDIES (IRB APPOVED)
Submitted abstracts ACC 2009 (Manuscripts in preparation)
1. Predictors Of Cardiovascular Events Following Myocardial Infarction: Role Of Non HDL cholesterol
In Patients With Average Cholesterol; A Cholesterol And Recurrent Events (CARE) trial Subgroup

Analyses. Nitin Mahajan, Luis Afonso, Judith Dunn, Frank Sacks, the CARE trial investigators,
Wayne State University, Detroit, MI, Harvard University, Boston, MA
2. Mortality and Predictors Of Cerebrovascular Events In Patients With Severe Systolic Dysfunction In
Sinus Rhythm: Is Left Ventricular Non Compaction An Underecognized Risk Factor? Nitin
Mahajan, Preeti Ramappa, Mengistu Simegn, Prateek Bhattacharya, Lakshmi Shankar, Ramesh
Madhavan, Luis Afonso, Wayne State University, Detroit, MI
3. Correlation of Lipid Profile and Angiographic Coronary Artery Disease Burden Among Elderly
Patients Undergoing Coronary Angiography Vikas Veeranna, Ashutosh Niraj, Hesham Fakhry,
Jyotiranjan Pradhan, Luis Afonso, Wayne State University, Detroit, MI
4. Correlation of Lipid Profile and Angiographic Coronary Artery Disease Burden Among Elderly
Patients Undergoing Coronary Angiography Vikas Veeranna, Ashutosh Niraj, Hesham Fakhry,
Jyotiranjan Pradhan, Luis Afonso, Wayne State University, Detroit, MI
5. Implantable Cardiac Defibrillator Shocks Do Not Predict Death in a Secondary Prevention Apurva
Badheka, Ankit Rathod,Mohammad A.Kizilbash, Zongshan Lai, Neha Garg,Samrat Bhat, Luis
Afonso, Sony Jacob, Wayne State University, Detroit,MI
6. Incident Diabetes Mellitus in Patients with Stable Coronary Artery Disease: Apurva Badheka, Neha
Garg, Mohammad A.Kizilbash, Samrat Bhat, Ankit Rathod, Sony Jacob, Luis Afonso, Wayne
State University, Detroit,MI
7. Predicting Critical Peripheral Arterial Disease in Patients with Stable Coronary Arterial Disease: A
Simple Risk Prediction Score :Apurva Badheka, Samrat Bhat, Mohammad A.Kizilbash, Neha Garg,
Ankit Rathod, Sony Jacob, Luis Afonso, Wayne State University, Detroit,MI
8. Strain Dispersion Index and Global Longitudinal Strain in Differentiating Hypertrophic
Cardiomyopathy From Other Forms of Left Ventricular Hypertrophy Mengistu Alemayehu Simegn,
Ashok Kondur, Pretty Ramappa, Tamam Mohammed, Luis Afonso
9. Survivors of sudden unexplained death in epilepsy are at significantly greater risk of recurrent
arrhythmias and death :Apurva Badheka, Ankit Rathod, Mohammad Kizilbash, Zongshan Lai, Neha
Garg, Samrat Bhat, Tamam Mohamad, Luis Afonso, Sony Jacob, Wayne State University, Detroit,
MI
10. Cardiac Troponin-I, In-Hospital Mortality and the Need for Emergency Valve Replacement Surgery
in Infective Endocarditis Mengistu Alemayehu Simegn, Fires Zahwe, Khaled Bachour, Tamam
Mohamad, Kidmealem Zekarias, Preeti Ramappa, Luis Afonso, Deepak Thatai
PRINCIPAL INVESTIGATOR : ORIGINAL ONGOING INVESTIGATIONS (IRB APPOVED)
1. Cardiac Magnetic Resonance Imaging in Peripartum Cardiomyopathy American College of
Cardiology (ACC Grant Submission, response awaited) Afonso L, Mohamad T, Badheka A,
Kondur A, Sorokin Y, Drennan K,Tao Li .
2. Risk of Thromboembolic Events in Patients with Severe Left Ventricular Dysfunction in Sinus
Rhythm. Afonso L, Mohammad T, Mittal P, Romero R. Li T
3. Speckle Tracking vs. Tissue Doppler Strain in Differentiating Hypertrophic Cardiomyopathy From
Other Forms of Left Ventricular Hypertrophy Afonso L, Simegn M, Kondur A, Ramappa P,
Mohammed T
4. Prevalence, Determinants and Clinical Significance of Cardiac Troponin Release in Patients with
Hypertensive Emergency Afonso L, Himabindu Bandaru H, Badheka A, Jacobsen G, Weaver D
Chattahi J (Study completed in collaboration with Henry Ford Hospital)
5. Role of Preload Status in the Assessment of Patent Foramen Ovale: Can Saline Loading Release
the Door Jam? Afonso L, Kottam A. ( Trainee Supervision)

6. Significance of Troponin Release in Intensive Care Patients : An assessment of short and long
term mortality. Afonso L ,Fakhry H, Bhat S, ( Trainee Supervision)
TRIAL RESEARCH (Multicenter Trials) Co-PI
2007
Cardiology -PI A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety
and Efficacy of SCH530348 in Addition to Standard of Care in Subjects With a History of Atherosclerotic
Disease: Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events
(TRA 2’P-TIMI-50)
2002
Co-investigator .Irbesartan in Heart Failure with Preserved Systolic function
(I-PRESERVE) Sponsored by Bristol-Myers Squibb.(VA Medical Center)
Effects of Angiotensin receptor blocker Irbesartan on left ventricular systolic and diastolic function
2002-03
Sub PI for A-HEFT( African-American Heart failure Trial) VA Medical Center
The assessment of Hydrallazine-Nitrates combination on the morbidity and mortality of Congestive Heart
Failure in African-Americans.
2001
Coinvestigator STICH Trial. The Surgical Treatment for Ischemic Heart
Failure assessing the benefits of aneurysmectomy in improving LV geometry and systolic function.
1999
Co investigator and Collaborating investigator in successful grant proposal for intramural funding for
research titled “ Effects of Adenosine on Microvascular Function in Patients with Acute Myocardial
infarction”. JR Spears, Luis Afonso, Eric Racine, James Janisse, Marcelo Di Carli.