Dr. Peter Durie - The Hospital for Sick Children

DIVISION HEAD 

Dr. Stanley Zlotkin 

FULL-TIME 

Dr. Peter Durie 

Dr. Nicola Jones 

Dr. Anne Griffi ths 

Dr. Simon Ling 

Dr. Vicky Ng 

Dr. Paul Pencharz 

Dr. Philip Sherman 

Dr. Mary Zachos 

PART-TIME 

Dr. Glenn Berall 

Dr. Carol Durno 

Dr. Paul Kortan 

Dr. Margaret Marcon 

Dr. Gary May 

CROSS-APPOINTEES 

Dr. Mary Corey 

CLINICAL FELLOWS 

Dr. Fatma Al-Madhaki 

Dr. Tanja Gonska 

Dr. Keith Ooi 

Dr. Juan Ossa 

RESEARCH FELLOWS 

Dr. Eric Benchimol 

Dr. Juan Gana 

Dr. Orlee Guttman 

Dr. Seamus Hussey 

Dr. Aleixo Muise 

Dr. Mary Sherlock 

Dr. Peter Durie 

Dr. Dan Turner 

Dr. Catharine Walsh 

Dr. Thomas Walters 

Dr. Eytan Wine 

Dr. Jason Yap

Division of Gastroenterology, Hepatology and Nutrition 

OVERVIEW 

The Division of Gastroenterology, Hepatology and 

Nutrition is one of the only programs in Canada with a 

fully integrated specialty program in clinical paediatric 

GI, hepatology, transplantation (liver and small bowel) 

and nutrition, and vertical programs in education and 

research which span the clinical spectrum. The 

program offers one year of clinical training and two 

research years. The clinical component includes a wide 

array of experiences including: procedures (endoscopy, 

manometry and calorimetry), inpatient management of 

complex patients, including those awaiting and 

undergoing transplantation, those with infl ammatory 

bowel disease and more; ambulatory clinics (including 

home TPN, dysphasia, general GI, IBD, hepatology, 

transplantation and nutrition); and evidence-based 

educational rounds and training in ethics and 

communication. Our research spans the spectrum from 

basic and translational to patient-based in such areas 

as infl ammatory bowel disease, pancreatic diseases, 

ulcer disease, liver diseases, GI microbiology and 

immunology, nutritional metabolism and nutrient 

requirements. Many of our trainees in the research 

program (two years) combine a formal degree-granting 

program at the University of Toronto (M.Sc. or PhD) 

within their research fellowship years. The majority of 

our fellows have gone on to very successful careers in 

academic paediatric gastroenterology. 

SUBSPECIALTY RESIDENTS 

Dr. Kesete Bezu 

ADMINISTRATIVE STAFF 

Chona Callejo 

Roxanne Francis 

Margaret Johnson 

Sherry Joy 

Nnenna Ngoka 

Lilatool Shakur 

Suzanne Shek 

This year, staff and fellows in the division have 

been honoured with awards, fellowships and named 

lectureships, including Canadian Association of 

Gastroenterology Visiting Professorship, Fellow of 

the American Society of Nutrition, the Joseph M. West 

Family Memorial Award, the Levy/Thomson Award for 

Outstanding Oral Presentation, the Miriam Neveren 

Memorial Award, the Canadian Child Health Clinician 

Scientist Program (CCHCSP) Career Enhancement 

Program Award, and many more. The staff members 

of the division have published over 60 peer-reviewed 

publications, nine books or book chapters and have 

received well over $10 million of grant funding for 

projects spanning the next fi ve years. 

HONOURS AND AWARDS 

Benchimol E: Canadian Child Health Clinician-Scientist 

Program Doctoral Award, 2008. 

Benchimol E: The Hospital for Sick Children Clinician- 

Scientist Training Program Research Fellowship, 2007. 

Benchimol E: Joseph M. West Family Memorial Fund, 

Department of Post-Graduate Medical Education, 

University of Toronto, 2007. 

Benchimol E: American College of Gastroenterology 

Clinical Research Award, 2007. 

Benchimol E: Trainee Scholarship, 

Gastroenterology Research Group and The American 

Gastroenterological Association Institute, 2007. 

Gana J: Canadian Child Health Clinician Scientist 

Program Career Enhancement Program Award, 2008. 

Gana J: Levy/Thomson Award for Outstanding Oral 

Presentation. Gana JC, Roberts EA, Ng VL, Ling SC. 

Non-invasive diagnosis of esophageal varices in 

children. Gastroenterology residents-in-training (GRIT) 

as part of the Canadian Digestive Diseases Week 

(CDDW), Montreal, 2008. 

Guttman O: CASL/Schering-Plough Canada 

Hepatology Fellowship, 2007. 

Hussey S: The CAG/CIHR/CCFC Fellowship, 2008-2010. 

Hussey S: The Chisholm Memorial Fellowship, 2008. 

Hussey S: The Elizabeth Arbuthnot Dyson 

Fellowship, 2008. 

Hussey S: The Miriam Neveren Memorial Award, 2008. 

Hussey S: The Edward Christie Stevens Fellowship, 2008. 

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 63

Ling SC: Paediatric Transplant Bursary Award, 

Canadian Transplant Society. Paediatric liver 

transplantation: 20-year experience at The Hospital 

for Sick Children. Canadian Society of Transplantation 

Annual Meeting, Mont-Tremblant, Quebec, 2008. 

Pencharz P: Fellow of the American Society 

for Nutrition, 2008. 

Sherman P: Canada Research Chair, Tier 1 

(renewal), 2008. 

Sherman P: Canadian Association of Gastroenterology 

Visiting Professor Award, 2008. 

Wine E: Canadian Child Health Clinician Scientist 

Program (CCHCSP) Career Enhancement Program 

Award, 2007. 

Wine E: The Hospital for Sick Children Clinician 

Scientist Training Program (CSTP), 2007. 

Wine E: The University of Toronto Faculty of Medicine, 

Postgraduate Award (Javenthey Soobiah, Charles 

Fell Charitable Trust, Chisholm Memorial Fellowship 

Joseph M. West Family Memorial Fund), 2007. 

64 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 

Wine E: Canadian Institute of Health Research/ 

Canadian Association of Gastroenterology/Industry 

(Astra Zeneca) Research Initiative Award, 2007. 

PUBLICATIONS 

Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, 

Briend A, Dewey KG: Randomized comparison of 

three types of micronutrient supplements for home 

fortifi cation of complementary foods in Ghana: 

effects on growth and motor development. American 

Journal of Clinical Nutrition 2007: 86: pp 412-420. 

Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, 

Briend A, Dewey KG: Home fortifi cation of 

complementary foods with micronutrient supplements 

is well accepted and has positive effects on infant 

iron status in Ghana. American Journal of Clinical 

Nutrition 2008: 87: pp 929-938. 

Ball RO, Urschel KL, Pencharz PB: Nutritional 

consequences of interspecies differences in arginine 

and lysine metabolism. Journal of Nutrition 2007: 137: 

pp 1626S-1641S. 

Barr R, Atkinson S, Pencharz P, Arguelles GR: Nutrition 

and cancer in children. Pediatric Blood and Cancer 

2008: 50(S2): p 437. 

Barron MA, Pencharz PB: Nutritional issues in infants 

with cancer. Pediatric Blood and Cancer 2007: 

49(S7): pp 1093-1096. 

Beck P, Shaffer E, Gall D, Sherman PM: The natural 

history and signifi cance of ultrasonographically 

defi ned polypoid lesions of the gallbladder in children. 

Journal of Pediatric Surgery 2007: 42: pp 1907-1912. 

Bellissimo N, Desantadina V, Pencharz PB, Berall GB, 

Thomas SG, Anderson GH: A comparison of short-term 

appetite and energy intakes in weight and obese boys 

following glucose and protein drinks. International 

Journal of Obesity 2008: 32: pp 362-336. 

Bellissimo N, Pencharz PB, Berall GB, Goode RC, 

Thomas SG, Anderson GH: Effect of television viewing 

at mealtime on food intake after a glucose preload 

in boys. Pediatric Research 2007: 61: pp 745-749.

Bellissimo N, Pencharz PB, Berall GB, Goode RC, 

Thomas SG, Anderson GH: Reproducibility of short- 

term food intake and subjective appetite scores after 

a glucose preload, ventilation threshold and body 

composition in boys. Applied Physiolology and 

Nutrition Metabolism 2008: 33: pp 326-337. 

Benchimol E, Kirsch R, Viero S, Griffi ths AM: 

Collagenous colitis and eosinophilic gastritis in a 

four-year old girl: a case report and review of the 

literature. Acta Paediatrica 2007: 96: pp 1365-1367. 

Benchimol EI, Seow CH, Steinhart AH, Griffi ths AM: 

Traditional corticosteroids for induction of remission 

in Crohn’s disease. Cochrane Database System 

Review 2008: 2: CD006792. 

Benchimol EI, Turner D, Mann EH, Thomas KE, 

Gomes T, McLernon RA, Griffi ths AM: Toxic megacolon 

in children with infl ammatory bowel disease: clinical 

and radiographic characteristics. American Journal of 

Gastroenterology 2008: May 26 [Epub ahead of print]. 

Castellani C, Cuppens H, Macek Jr M, Cassiman JJ, 

Kerem E, Durie P, Tullis E, Assael BM, Bombieri C, 

Brown A, Casals T, Claustress M, Cutting GR, 

Dequeker E, Dodge J, Doull I, Farrell P, Ferec C, 

Girodon E, Johannesson M, Kerem B, Knowles M, 

Munck A, Pignatti PF, Radojkovic D, Rizzotti P, Schwarz 

M, Stuhrmann M, Tzetis M, Zielenski J, Elborn JS: 

Consensus on the use and interpretation of cystic 

fi brosis mutation analysis in clinical practice. Journal 

of Cystic Fibrosis 2008: 7: pp 179-196. 

Dassopoulos T, Nguyen GC, Sitton A, Bromfi led GP, 

Schumm LP, Wu Y, Riguiero M, Siemanowski B, 

Griffi ths AM, Brant S, Rious JD, Yang H, Duerr RH, 

Silverberg M, Cho JH, Steinhart H: Assessment of 

reliability and validity of IBD phenotyping within the 

NIDDK IBD genetics consortium (IBDGC). 

Infl ammatory Bowel Diseases 2007: 13: pp 975-983. 

Dorfman R, Sandford A, Taylor C, Huang B, 

Frangolias D, Wang Y, Sang R, Pereira L, Sun L, 

Berthiaume Y, Tsui L-C, Paré PD, Durie P, Corey M, 

Zielenski J: Complex two-gene modulation of lung 

disease severity in children with cystic fi brosis. Journal 

of Clinical Investigation 2008: 118: pp 1040-1049. 

Draper H, Diamond IR, Temple M, John P, Ng VL, 

Fecteau A: Multimodal management of endangering 

hepatic hemangioma impact on transplant avoidance. 

Journal of Pediatric Surgery 2008: 43: pp 120-126. 

Elango R, Ball RO, Pencharz PB: Indicator amino 

acid oxidation: concept and application. Journal 

of Nutrition 2008: 138: pp 243-246. 

Elango R, Ball RO, Pencharz PB: Individual amino acid 

requirements in humans: an update. Current Opinion 

in Nutrition and Metabolic Care 2008: 11: pp 34-39. 

Elango R, Humayun MA, Ball RO, Pencharz PB: Lysine 

requirement of healthy school-age children determined 

by indicator amino acid oxidation method. American 


Gao Y, Sherman PM, Sun Y, Li D: Multiplexed 

high-throughput electrokinetically-controlled 

immunoassay for the detection of specifi c bacterial 

antibodies in human serum. Analytica Chimica Acta 

2008: 606: pp 98-107. 


Gareau M, Jury J, MacQueen G, Sherman PM, 

Perdue M: Probiotic treatment of rat pups normalizes 

corticosterone release and ameliorates colonic 

dysfunction induced by maternal separation. Gut 

2007: 56: pp1522-1528. 

Green GJ, Weitzman SS, Pencharz PB: Resting energy 

expenditure in children with stage IV neuroblastoma. 

Pediatric Research 2008: 63: pp 332-336. 

Heuschkel R, Salvestrini C, Beatties RM, Hildebrand H, 

Walters T, Griffi ths AM: Guidelines for the 

management of growth failure in childhood 

infl ammatory bowel disease. Infl ammatory Bowel 

Diseases 2008: 14: 839-849. 

Humayun MA, Elango R, Ball RO, Pencharz PB: A 

re-evaluation of protein requirement in young men using 

the indicator amino acid oxidation technique. American 



Humayun MA, Elango R, Moehn S, Ball RO, 

Pencharz PB: Application of the indicator amino acid 

oxidation technique for the determination of metabolic 

availability of sulphur amino acids from casein versus 

soy protein isolate in adult men. Journal of Nutrition 

2007: 137: pp 1874-1879. 

Hussey S, Terebiznik MR, Jones NL: Autophagy: healthy 

eating and self digestion for gastroenterologists. 

Journal of Pediatric Gastroenterology, Hepatology, 

Nutrition 2008: 46: pp 496-506. 

Ip H, Hyder Z, Haseen F, Rahman M, Zlotkin S: 

Improved adherence and anemia cure rates with 

fl exible administration of micronutrient Sprinkles: 

a new public health approach to anaemia control. 

European Journal of Clinical Nutrition 2007: 

September 26 [Epub ahead of print]. 

Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, 

Rioux RD, Brant SR, Silverberg MS, Taylor KD, 

Barmada MM, Bitton A, Dassopoulos T, Datta LW, 

Green T, Griffi ths AM, Kistner EO, Murtha MT, 

Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, 

Targan SR, Xavier R, the NIDDK IBD Genetics 

Consortium, Libioulle C, Sandor C, Lathrop M, 

Belaiche J, Dewit O, Gut I, Heath S, Laukens D, 

Mni M, Rutgeerts P, Van Gossum A, Zelenika D, 

Franchimont D, Hugot JP, de Vos M, Vermeire S, 

Louis E, the Wellcome Trust Case Control Consortium, 

Cardon LR, Anderson CA, Drummond H, Nimmo E, 

Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Ghori J, 

Bumpstead S, Gwillam R, Tremelling M, Deloukas P, 

Mansfi eld J, Jewell D, Satsangi J, Mathew CG, 

Parkes M, Georges M, Daly MJ. Genome-wide 

association defi nes more than 30 distinct 

susceptibility loci for Crohn’s disease. Nature 

Genetics 2008: June 29 [online publication].

Johnson-Henry K, Donato K, Gordanpour M, 

Sherman PM: Lactobacillus rhamnosus strain GG 

prevents enterohemorrhagic Escherichia coli-induced 

changes in epithelial barrier function. Infection and 

Immunity 2008: 76: pp 1340-1348. 

Kappelman M, Bousvaros A, Hyams J, Markowitz J, 

Griffi ths AM and the Pediatric IBD Registry Group: 

Variation in the initial management of children with 

Crohn’s disease. Infl ammatory Bowel Diseases 2007: 

13: pp 890-895. 

Kugathasan S, Nebel J, Skelton J, Markowitz J, Keljo D, 

Griffi ths AM, Bousvaros A, Hyams J: Body mass index 

in children with newly diagnosed infl ammatory bowel 

disease: observations from two multicentre North 

American inception cohorts. Journal of Pediatrics 

2007: 151: pp 523-527. 

Leach ST, Mitchell HM, Geczy CL, Sherman PM, Day AS: 

S100 calgranulin proteins S100A8, S100A9 and 

S100A12 are expressed in the infl amed gastric mucosa 

of helicobacter pylori-infected children. Canadian 

Journal of Gastroenterology 2008: 22: pp 461-464. 

Lenoir-Wijnkoop I, Sanders M, Cabana M, Caglar E, 

Corthier G, Rayes N, Sherman PM, Timmerman H, 

Vaneechoutte M, Van Loo J, Wolvers D: Probiotic 

and prebiotic infl uence beyond the intestinal tract. 

Nutrition Reviews 2007: 65: pp 469-489. 

Lewis K, Caldwell J, Phan V, Prescott D, Nazli A, 

Wang A, Soderholm J, Perdue M, Sherman PM, 

McKay D: Decreased epithelial barrier function evoked 

by exposure to metabolic stress and non-pathogenic E. 

coli is enhanced by TNFα. American Journal of 

Physiology 2008: 294: pp G669-G678. 

Ling SC: Congenital cholestasis syndromes: what 

happens when children grow up? Canadian Journal 

of Gastroenterology 2007: 21: pp 743-751. 

Madore A-M, Prevost C, Dorfman R, Taylor C, Durie P, 

Zielenski J, Laprise C: Distribution of CFTR mutations 

in Saguenay-Lac-Saint-Jean: proposal of a panel of 

mutations for population screening. Genetics in 

Medicine 2008: 10: pp 201-206. 

Mager D, Marcon M, Wales P, Pencharz PB: Use 

of N-acetyl cysteine for the treatment of parenteral 

nutrition (PN) induced liver disease in children on 

home PN. Journal of Pediatric Gastroenterology 

and Nutrition 2008: 46: pp 220-223. 

Moehn S, Bertolo RFP, Martinazzo-Dallagnol E, 

Pencharz PB, Ball RO: Metabolic availability of lysine 

in feedstuffs determined using oral isotope delivery. 

Livestock Science 2007: 109: pp 24-26. 

Muise AM, Walters TD, Wine E, Griffi ths AM, Turner D, 

Duerr RH, Regueiro MD, Ngan BY, Xu W, Sherman PM, 

Silverberg MS, Rotin D: Protein tyrosine phosphatase 

sigma is associated with ulcerative colitis. Current 

Biology 2007: 17: 1212-1218. 

Nasr A, Avitzur Y, Ng VL, De Silva N, Wales PW: The 

use of conjugated hyperbilirubinemia greater than 100 

lmol/L as an indicator of irreversible liver disease in 

infants with short bowel syndrome. Journal of 

Pediatric Surgery 2007: 42: pp 359-362. 

Ng VL, Anand R, Martz K, Fecteau A: Liver 

retransplantation in children: SPLIT database analysis 

of outcome and predictive factors for survival. American 

Journal of Transplantation 2008: 8: pp 386-395. 


Ng VL, Otley AR: Understanding quality of life for 

children after liver transplantation: a work in progress. 

Liver Transplantation 2008: 14: pp 415-417. 

O’Shea A-M, Wilson G, Ling SC. Minassian B, Cutz E: 

Lafora-like ground glass inclusions in hepatocytes of 

paediatric patients–report of two cases. Pediatric and 

Developmental Pathology 2007: 10: pp 351-357. 

Panaccione R, Fedorak R, Aumais G, Bernard E-J, 

Bernstein CN, Bitton A, Croitoru K, Dieleman LA, 

Enns R, Feagan BG, Franchimont D, Greenberg GR, 

Griffi ths AM, Marshall J, Pare P, Patel S, Penner R, 

Render C, Seidman E, Steinhart AH: Review and 

clinical perspectives for the use of infl iximab in 

ulcerative colitis. Canadian Journal of 

Gastroenterology 2008: 22: 261-272. 

Pencharz P: Energy balance and body composition. 

Pediatric Blood and Cancer 2008: 50: p 468. 

Pencharz PB, Hsu JW, Ball RO: Aromatic amino acid 

requirements in healthy human subjects. Journal of 

Nutrition 2007: 137: pp 1576S-1578S. 


Pencharz PB: Assessment of protein nutritional status. 

Pediatric Blood and Cancer 2008: 50(S2): pp 445-446. 

Puntai J, Markowitz J, Lerer T, Hyams J, Kugathasan S, 

Griffi ths AM, Otley A, Crandall W, the Pediatric IBD 

Collaborative Research Group: The effect of early 

immunomodulator use in moderate to severe pediatric 

Crohn disease. Infl ammatory Bowel Diseases 2008: 

February 17 [Epub ahead of print]. 

Rafi i M, Elango R, Courtney-Martin G, House J, Fisher L, 

Pencharz PB: High-throughput and simultaneous 

measurement of homocysteine and cysteine in 

human plasma and urine by liquid chromatography- 

electrospray tandem mass spectrometry. Analytical 

Biochemistry 2007: 371: pp 71-81. 

Rafi i M, McKenzie JM, Roberts SA, Steiner G, Ball RO, 

Pencharz PB: The in vivo regulation of phenylalanine 

hydroxylation using enrichment in Apo-B 100. American 

Journal of Physiology 2008: 294: pp E475-E479. 

Rosh JR, Gross T, Mamula P, Griffi ths AM, Hyams J: 

Hepatosplenic T-cell lymphoma in adolescents and 

young adults with Crohn’s disease: a cautionary tale. 

Infl ammatory Bowel Diseases 2007: 13: pp 1024-1030. 

Samonte V, Sherman PM, Taylor G, Carricato M, 

Fecteau A, Ling S, Ng V: Scurvy diagnosed in a 

pediatric liver transplant patient awaiting combined 

kidney and liver retransplantation. Pediatric 

Transplantation 2008: 12: pp 363-367. 

Shakur YA, Richards H, Pencharz PB: Is it necessary 

to measure resting energy expenditure in clinical 

practice in children. Journal of Pediatrics 2008:152: 

pp 437-439. 

Sharieff W, Dofonsou J, Zlotkin S. Is cooking food in 

iron pots an appropriate solution for the control of 

anaemia in developing countries? A randomized clinical 

trial in Benin. Public Health Nutrition 2007: 15: pp 1-7.

Shugart YY, Silverberg MS, Duerr RH, Taylor KD, 

Wang MH, Zarfas K, Schumm LP, Bromfi elf G, 

Steinhart AH, Griffi ths AM, Kane SV, Barmada MM, 

Rotter JI, Mei L, Bernstein CN, Bayless TM, Langelier D, 

Cohen A, Bitton A, Rioux JD, Cho JH, Brant SR: 

An SNP linkage scan identifi es signifi cant Crohn’s 

disease loci on chromosomes 13q13.3 and, in Jewish 

families, on 1p35.2 and 3q29. Genes and Immunity 

2008: 9: pp 161-167. 

Toiviainen-Salo S, Raade M, Durie PR, Ip W, Marttinen E, 

Savilahti E, Makitie O: MRI fi ndings of the pancreas in 

patients with Shwachman-Diamond syndrome and 

mutations in the SBDS gene. Journal of Pediatrics 

2008: 152: pp 434-436. 

Turner D, Griffi ths AM: Esophageal, gastric and 

duodenal manifestations of IBD, and the role of upper 

endoscopy in IBD diagnosis. Current Gastroenterology 

Reports 2007: 9: pp 475-478. 

Turner D, Grossman A, Rosh J, Gilman AR, 

Kugathasan S, Baladassano R, Griffi ths AM: 

Methotrexate following unsuccessful thiopurine 

therapy in pediatric Crohn’s disease. American Journal 

of Gastroenterology 2007: 102: pp 2804-2812. 

Turner D, Otley AR, Mack D, Hyams J, de Bruijne J, 

Uusoue K, Walters TD, Zachos M, Mamula P, 

Beaton DE, Steinhart AH, Griffi ths AM: Development, 

validation, and evaluation of pediatric ulcerative 

colitis activity index: a prospective multicentre study. 

Gastroenterology 2007: 133(2): pp 423-432. 

Turner D, Steinhart AH, Griffi ths AM: Omega-3 fatty 

acids (fi sh oil) for maintenance of remission in 

ulcerative colitis. Cochrane Database System 

Review 2007: CD006443. 

Turner D, Walsh CM, Benchimol EI, Mann EH, 

Thomas KE, Chow C, McLernon RA, Walters TD, 

Steinhart AH, Griffi ths AM: Severe paediatric ulcerative 

colitis: incidence, outcomes, and optimal timing for 

second line therapy. Gut 2008: 57: pp 331-338. 

Urschel KL, Rafi i M, Pencharz PB, Ball RO: A multitracer 

stable isotope quantifi cation of the effects of 

arginine intake on whole-body arginine metabolism in 

neonatal piglets. American Journal of Physiology 

2007: 293: pp E811-E818. 

Wallon C, Yang PC, Keita A, Ericson AC, McKay DM, 

Sherman PM, Perdue MH, Soderholm JD: Corticotropinreleasing 

hormone (CRH) regulates macromolecular 

permeability via mast cells in normal human colonic 

biopsies in vitro. Gut 2008: 57: pp 50-58. 

Ward LM, Gaboury I, Ladhani M, Zlotkin S: Vitamin 

D-defi ciency rickets among children in Canada. Canadian 

Medical Association Journal 2007: 177: pp 161-166. 

Wilschanski M, Durie PR: Patterns of GI disease in 

adulthood associated with mutations in the CFTR 

gene. Gut 2007: 56: pp 1153-1163. 

Zlotkin S: Editorial - ‘Control of Anemia: the time to act 

is now’. Indian Pediatrics 2007: 44: pp 84-86. 


BOOKS AND BOOK CHAPTERS 

Anemia Review Panel: anaemia Guidelines for Family 

Medicine, 2nd Edition. MUMS Guideline Clearinghouse, 

Toronto, 2008. 

Durie PR: Schwachman-Diamond Syndrome. In: 

Pediatric Gastrointestinal Disease, 5th Edition, 

Volume 2 (Kleinman RE, Sanderson IR, Goulet O, 

Sherman PM, Mieli-Vergani G, Shneider BL, eds.). 

BC Decker Inc., Hamilton, 2008. 

Griffi ths AM, Carricato M: Enteral nutrition 

in infl ammatory bowel disease. In: Pediatric 

Nutrition in Practice (Berthold K, ed.) Karger, 

Basel, Switzerland, 2008. 

Griffi ths AM, Hugot J-P: Crohn’s disease. In: Paediatric 

Gastrointestinal Disease, 5th Edition, Volume 1 

(Kleinman R, Goulet O, Mieli-Vergnani G, Sherman P, 

Schneider B, eds.). BC Decker Inc., Hamilton, 2008. 


Wallace J, Sherman PM: Resolution of mucosal 

infl ammation. In: Progress in Infl ammation Research 

Series: Resolution of Infl ammation (Rossi A, 

Sawatsky D, eds.) Berkhauser Verlag AG, Basel, 2007. 

Walters TR, Griffi ths AM: Growth impairment in IBD. 

In: Pediatric Infl ammatory Bowel Disease (Baldassano 

R, Mamula P, Markowitz J, eds.). Springer, USA, 2008. 

Wine E, Terebiznik M, Jones NL: Microbial interactions 

with gut epithelium. In: Paediatric Gastrointestinal 

Disease, 5th Edition, Volume 1 (Kleinman R, Goulet O, 

Mieli-Vergnani G, Sherman P, Schneider B, eds.). 

BC Decker Inc., Hamilton, 2008. 

FUNDING 

A multicentre study of the safety and effi cacy of 

N-acetylcysteine in the treatment of acute liver failure 

in paediatric patients not caused by acetaminophen. 

Ng VL, Fecteau A. National Institutes of Health/ 

National Institute of Diabetes and Digestive and 

Kidney Diseases (US$69,000 2005-2010) 

A multi-disciplinary human study on the genetic, 

environmental and microbial interactions that cause 

IBD. Croitoru K, Griffi ths AM, Ropelski M, Moyeddi P. 

Crohn’s and Colitis Foundation of Canada 

($5,600,000 2007-2012) 

A novel candidate susceptibility gene at the IBD6 

locus. Griffi ths AM, Rotin D. Crohn’s and Colitis 

Foundation of Canada New Innovations Grant 

($50,000 2007) 

A prospective study of linear growth in paediatric 

IBD. Denson LA, Griffi ths AM. Crohn’s and Colitis 

Foundation of America ($150,000 per year 2007- 

2010) 

Adalimumab in pediatric Crohn’s disease: a multicentre 

study. Griffi ths AM. Abbott Laboratories (per patient 

remuneration; anticipated $90,000 2007-2009)

Arginine and CF. Grasemann H, Ratjen F, 

Pencharz P. Canadian Cystic Fibrosis Foundation 

($140,000 2007-2010) 

Assessment of activity and prediction of outcome in 

paediatric ulcerative colitis. Turner D, Steinhart H, 

Griffi ths AM. Canadian Association of 

Gastroenterology/Canadian Institutes of Health 

Research ($65,000 per year 2006-2008) 

Cell signals: cell signalling in mucosal infl ammation 

and pain. Ellen R, Jones NL. Canadian Institutes 

of Health Research ($300,000 2002-2008) 

Clinical Research Facilitation Award. Durie PR. Cystic 

Fibrosis Foundation Therapeutics, Inc. 

(US$108,280 2007-2008) 

Clinician scientist training program in clinical nutrition 

research. Pencharz P. Canadian Institutes of Health 

Research ($265,000 2002-2008) 

Determining the threshold of CFTR function that 

causes CF disease. Durie PR. Canadian Cystic 

Fibrosis Foundation ($110,000 per year 2005-2008) 

Development and validation of a disease-specifi c 

health-related quality of life questionnaire for children 

after liver transplantation. Otley AR, Ng VL, Nicholas 

DB, Thompson J, Gilmour S, Watters C. Canadian 

Institutes of Health Research ($280,576 2005-2009) 

Development and validation of an objective skill 

assessment for colonoscopy. Ling SC, Walsh C. 

The Hospital for Sick Children Paediatric 

Consultants Partnership ($4,968 2007) 

Development of a new sweat test using sweat 

potential measurements. Durie PR. Cystic Fibrosis 

Foundation Therapeutics, Inc. ($70,818 US 2008) 

Development of a piglet short gut model. Turner J, 

Ball R, Pencharz P, Wales P. Stollery Children’s 

Hospital Foundation ($29,223 2007) 

Diagnosing cystic fi brosis in neonates and adults: 

where do we draw the line? Durie PR, Tullis E, 

Ratjen F. Canadian Cystic Fibrosis Foundation 

($120,000 per year 2008-2011) 

Epidemiology of eosinophilic esophagitis in children 

and adolescents in Canada. Marcon MA, Dourin E. 

Directing study which involves all 16 paediatric 

centres in Canada. J. Campbell Fund ($62,966 

2006-2008) 

Evaluation of a novel parenteral lipid source in the 

prevention of PN associated cholestasis. Wales P, 

Pencharz P. Fresenius-Kabi ($159,850 2008) 

Evaluation of CFTR function ex-vivo in sweat glands 

of perfused skin as a translational tool for future drug 

trials in CF. Durie PR, Pang C, Bear CE, Gonska T. 

(SickKids) Research Institute, New Ideas Grant 

($50,000 2008-2009) 

Food intake control in children. Anderson GH, 

Berall GB, Goode RC, Pencharz PB. Canadian 


Functional outcomes after paediatric liver 

transplantation. Ng VL, Fecteau A. National Institutes 

of Health/National Institute of Diabetes and 

Digestive and Kidney Diseases (US$6,000 2007-2008) 


Genetic predictors of time to recurrence following ileal 

resection in early onset Crohn’s disease. McLeod R, 

Griffi ths AM. Crohn’s and Colitis Foundation 

of Canada ($150,000 per year 2007-2010) 

Host responses to Helicobacter pylori infection: 

role of STAT3 during H. pylori infection. Jones NL. 

Canadian Institutes of Health Research 

($100,000 2007-2008) 

Immune regulation and biomarker development in 

paediatric and adult onset human autoimmune 

diseases. Bar-Or A, Banwell B, Piccirillo CA, 

Polychronakos C, Sherman PM. Canadian Institutes of 

Health Research Team Grant ($2,018,445 2007-2112) 

Induction of autophagy by H. pylori. Jones NL. 

Canadian Association of Gastroenterology/ 

Canadian Institutes of Health Research/Abbott 

($45,000 2007-2009) 

Infl iximab in paediatric ulcerative colitis: a multicentre 

study. Griffi ths AM. Centocor (per patient 

remuneration; anticipated $100,000 2007-2009) 


Innovative strategies for optimizing management 

of infants with biliary atresia. Guttman O 

(co-supervisors: Ng VL, Roberts EA.) Canadian 

Association for the Study of Liver Disease/ 


Fellowship Award ($55,000 2007-2008) 

International Collaboration Project. Zlotkin S. 


($25,000 2007-2008) 

Investigation of Helicobater pylori survival in host cells. 

Jones NL. Early Researcher Award, Ontario Ministry 

of Research and Innovation ($150,000 2006-2011) 

Knowledge translation award. Zlotkin S. Canadian 


Molecular genetics, SBDS function and defi ciency in 

SDS. Rommens JM, Durie PR. National Institutes of 

Health ($1,250,000 2004-2009) 

Neonatal protein and energy metabolism. Pencharz P. 

Medical Research Council/Canadian Institutes of 

Health Research ($136,817 2006-2011) 

North American IBD Genetics Consortium. Cho J, 

Duerr R, Silverberg M, Griffi ths AM, Rotter J, 

Brandt S, Rioux J. National Institutes of Health 

($3,000,000 2007-2011) 

Opportunity fund: funding for infrastructure associated 

with a Canada Research Chair. Sherman PM. Canada 

Foundation for Innovation, Leaders ($427,348 total 

[$170,939 direct from CFI] 2008) 

Outcomes in severe paediatric ulcerative colitis: 

a multicentre study. Griffi ths AM. Schering Canada 

($350,000 2007-2009) 

Pico-salax versus poly-ethylene glycol for bowel 

cleanout before colonoscopy in children: a single 

blinded randomized controlled trial. Ling SC, Griffi ths AM, 

Turner D. Ferring Inc. ($24,000 2006-2008) 

Protocol AI463-08: evaluation of the 

pharmacokinetics, safety, tolerability and effi cacy 

of entecavir (ETV) in paediatric subjects with chronic 

hepatitis B virus (HBV) infection who are HBeAgpositive. 

Ling SC. Bristol-Myers Squibb 

($25,000 per patient, 2007-2013)

Role of autophagy in Helicobacter pylori infection 

and disease. Jones NL. Canadian Institutes of Health 

Research ($103,959 per year 2008-2013) 

Role of probiotics in the management of experimental 

infl ammatory bowel disease. Sherman PM. Crohn’s 

and Colitis Foundation of Canada Fay Shapiro Cutler 

Grant-In-Aid of Research ($375,000 2007-2010) 

Salary award: Tier 1 (renewal). Sherman PM. 

Canada Research Chair ($1,400,000 2008-2015) 

SBDS protein expression in peripheral blood 

leukocytes. Durie PR, Rommens JM, Shimamura A. 

Shwachman Diamond Syndrome Foundation 

(US$30,000 per year 2006-2008) 

Short bowel syndrome, neonatal piglet model. Turner J, 

Ball R, Pencharz P, Wales P. SickKids Foundation 

($62,690 2008-2009) 

Sprinkles project support. Zlotkin S. HJ Heinz 

Company Foundation ($600,000 2006-2007) 

Studies of paediatric liver transplantation (SPLIT). 

Ng V, Fecteau A. National Institutes of Health/ 

National Institute of Diabetes and Digestive and 

Kidney Diseases (US$75,000 2005-2010) 

Studies of primary sclerosing cholangitis (STOPSC). 

Ling SC, Durie P, Griffi ths AM. Musette and Allen 

Morgan Jr. Foundation (annual and patient-based 

stipends, $10,000 per year plus $200 per patient 

2006-2009) 

Targeted small molecule therapies for cystic 

fi brosis. Bear CE, Deber CM, Durie PR, Lingwood C, 

Rotin D, Ratjen F, Yeger H. Canadian Cystic 

Fibrosis Foundation - BREATHE Program 

($480,000 per year 2004-2009) 

Team in childhood obesity research. McCrindle B, 

Anderson GH, Hamilton J, Parkin P, Pencharz P. 


($506,842 2008; $464,474 2008-2011) 

The contribution of genetic modulators of disease 

severity in cystic fi brosis to other diseases with 

similarities of clinical phenotype. Durie PR, Zielenski J. 

Genome Canada ($5,787,662 2005-2009) 

The use of indicator amino acid oxidation to determine 

amino acid requirement. Pencharz P, Ball R. Medical 

Research Council/Canadian Institutes of Health 

Research ($152,967 2005-2010) 

Training grant: cell signalling in mucosal infl ammation 

and pain. Ellen R, Sherman PM. Canadian Institutes 

for Health Research ($300,000 per year 2002-2008) 

Upper limits of leucine requirements. Pencharz P. 

International Council for Amino Acid Science 

($155,850 2008) 

VX06-770-101: a Phase 2a, randomized, double-blind, 

placebo controlled study of VX770 in patients with 

cystic fi brosis having G551D mutations to evaluate 

safety, phamacokinetics and biomarkers of CFTR 

activity. Durie PR (Toronto site). Vertex Pharmaceuticals, 

Inc. (US$30,000 per year 2007-2008)

Dr. Peter Durie - The Hospital for Sick Children

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