Annual Report 2001 - The Hospital for Sick Children

department of
paediatrics
The Hospital
for Sick Children
University of Toronto
2001–2002 annual report

Contents
Chair’s report 2
Divisional overviews
Adolescent Medicine 5
Cardiology 7
Clinical and Metabolic Genetics 11
Clinical Pharmacology 15
Emergency Services 18
Endocrinology 20
GI/Nutrition 22
Haematology/Oncology 26
Immunology/Allergy 32
Infectious Diseases 33
Neonatology 36
Nephrology 40
Neurology 42
Paediatric Medicine 45
Respiratory Medicine 49
Rheumatology 52
Inter-Divisional Colleagues 56
Paediatric Housestaff 57
Awards 58
Promotions 60
iii

department of
paediatrics
The Hospital
for Sick Children
University of Toronto

The 2001-2 academic year was a success
from many perspectives and the
following highlight but a few of the
many achievements of our academic
paediatricians. The broad scope of our faculty’s
contributions to clinical care, education,
research and administration are outlined on
our own (www.utoronto.ca/paedadm/index.html
and www.sickkids.ca/ ) and related web sites.
We are a research intensive Department. Our
excellent research productivity is evidenced by
the peer reviewed publications and grants
listed within this annual report and the many
presentations made by our faculty at local,
regional and international meetings. This year,
I draw special attention to our young clinicianscientists
who are presently within or have
recently emerged from the Scientist – track
career pathway. I am extremely proud of their
outstanding achievements which, in part,
reflect the strong and effective collaboration
between our Department and the Research
Institute of The Hospital for Sick Children
(http://www.sickkids.on.ca/research/ ) These
young clinician researchers ensure that our
Department will continue to develop new
strategies to maintain the health of children
and new cures for childhood disease. The
Department’s focus on training the next
generation of Canadian paediatric researchers
is perhaps best illustrated by our annual
Paediatric Resident and Fellows Research Day.
This year our faculty were witness to oral and
poster presentations from 31 of our trainees.
This annual celebration of our residents’ and
fellows’ research achievements has been
enhanced by the move to an off-site location
and the timely and extremely generous
endowment fund provided by the Lint Family
to fund these annual activities in perpetuity.
Our Department’s Annual Awards day once
2002 Annual Report CHAIR’S REPORT
again provided us the opportunity to recognize
our faculty’s continued outstanding
contributions to academic paediatrics and
specifically to acknowledge our colleagues
who were promoted to the more senior
academic ranks. In the past academic
promotion typically focused on research but
more recently achievements in education has
become an equally respected and well
“benchmarked” platform for promotion.
However, this year I draw special attention to
the individuals who were promoted on the
basis of their creative professional activities.
Such achievements have in the past been
inadequately recognized despite the fact that
such activities clearly differentiate our
academic paediatricians from those physicians
who make important contributions to our
society at large by providing front line care to
children outside of the academic world.
Several events have served as a testimony to
our Department’s excellent contributions in
education. Two of our paediatricans have
recently taken major leadership roles in
undergraduate medical education within the
decanal office. Also, our Associate Chair of
Education led the Faculty wide Internal Review
Committee that assessed all of our Faculty’s
training programmes prior to the Royal College
of Physician and Surgeon of Canada’s
laudatory accreditation review. These
appointments combined with the numerous
major contributions in undergraduate, postgraduate
and continuing education arenas
leave no doubt of our accomplishments in
training the future physicians who will care for
children and provide leadership at Canadian
and international universities.
During the early part of my chairmanship we
established the Richard Rowe Award for
Clinical Excellence; this was an important step

in the recognition of those individuals who
provided outstanding scholarly care for
children at The HSC. This award is now
complemented by a comparable award
recognizing the excellence in clinical care by a
paediatrician within their first 10 years of
appointment at an academic health science
centre. These highly visible awards together
with clearly outlined career pathways for
clinician specialists emphasize the value that
we place on providing scholarly state of the
art care to our children
One of my major priorities has been to
promote the career development of our
paediatricians. An initial important step
occurred in 1997 when we developed clearly
defined Job Activity profiles (JAP,
Clinician–Scientist, Clinician -Specialist,
Clinician–Investigator, Clinician–Educator,
Clinician–Teacher, and Clinician –
Administrator) for each paediatrician. This
recognized the critical role that each JAP plays
in maintaining and enhancing a paediatric
academic health science centre and our
respected colleagues developed a “road-map”
of achievements which characterized the
successful career development in the clinical
care, medical education and research arenas.
These steps, combined with the formal
implementation of mentorship programmes for
all JAPs, are part of The HSC’s Department of
Paediatrics / Paediatric Consultants
Partnership’s Career Development and
Compensation Programme (CDCP). The CDCP is
not only a critical factor in the career
development of our paediatricians but is also
the instrument by which peer review is carried
out and personal remuneration is determined.
During 2001, the CDCP underwent a “selfexamination”
where our HSC based full time
paediatricians evaluated its merits and
outlined its deficiencies (O’Brodovich et al,
Pediatrics, Volume III, No. 1 January 2003). This
process concluded that the CDCP had, from an
overall point of view, been successful in
addressing its original goals, was an improvement
over previous approaches, and did not require
a major redesign. There were areas needing
improvement which are now being addressed.
The successful re-negotiation of The HSC’s
Department of Paediatrics / Paediatric
Consultants Partnership Alternative Funding
Plan (AFP, 2001-6) is remarkable for several
reasons. First, it allows me to financially
better recognize our outstanding
paediatricians. Second we are hiring new
academic paediatricians, many from other
regions of Canada and from different
continents throughout the world. However, of
greatest importance, is the new partnership
established with the HSC Foundation who will
now recognize the time spent by our clinician
researchers who develop new cures for the
children of Ontario and the world.
In closing, I would like to take this
opportunity to once again thank the members
of my Department and its trainees for their
contributions to the immediate and future
well-being of infants and children and ask you
to share in their accomplishments described
within the 2001 – 2002 annual report.
Hugh O’Brodovich MD, FRCP(C)
Paediatrician-in-Chief, Hospital for Sick Children
Professor of Paediatrics and Physiology
Chair of Paediatrics University of Toronto
Senior Scientist, Hospital for Sick Children Research Institute
R.S. McLaughlin Foundation Chair in Paediatrics
at The Hospital for Sick Children
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2002 Annual Report CHAIR’S STATEMENT
divisional
overviews

Division of ADOLESCENT MEDICINE
teaching faculty Eudice awards Goldberg MD - Chief, Debra Katzman MD, research Miriam Kaufman awards substance use, HIV educational interventions with
Harry MD, Karen Bain Leslie Award MD, Stephen to a Rivers full-time PhD, C Psych part-time Frederick Afsoon FitzGerald incarcerated Tisdall Awards youth, and health values in adolescents
Fathollahzadeh, member of the Christina Department Grant MD, Elyea of Noriega MD, for Miriam excellence Rossi MD, in resident with chronic research. illnesses.
clinical fellows April Elliott MD
Paediatrics who demonstrates
General Paediatric Section
excellence iun teaching as
1st Place:
The Division of Adolescent Medicine continues to focus
nominated by core paediatric
Dr. Sue Stock, PGY3
its clinical activities in four program areas – eating
residents.
disorders, substance abuse, young families, 2nd and Place complex tie:
publications
Geist R, Heinmaa M, Stephens D, Davis R, Katzman DK: Comparison
of family therapy and family group psychoeducation in adolescents
with anorexia nervosa. Canadian Journal of Psychiatry: 2000: 45:
173-178.
Dr. adolescent Michelle Shouldice, problems. Paediatric Having Medicine received special Dr. Marilyn funding Abraham, PGY2 Katzman and DK: In opposition of HRT. Journal of Paediatric Adolescent
from the Ministry of Health, a Day Hospital Dr. was Valerie launched Waters, PGY2
Gynecology: February 2001: 14: 39-41.
Marvin this April Gerstein in the Eating Award Disorders to a part- Program, allowing for Katzman DK, Christensen B, Young AR, Zipursky RB: Starving the
brain: structural abnormalities and cognitive impairment in
time the full member continuum of the of Department care to children of and adolescents adolescents with anorexia nervosa. Seminars in Clinical
Paediatrics with eating who disorders. demonstrates In addition to outpatient Paediatric and Subspecialty Neuropsychiatry: Section 2001: 6: 146-152
excellence inpatient tertiary in teaching care facilities, as nominated the Day 1st Hospital Place:
Leslie K: Substance Abuse and The Adolescent with Diabetes Mellitus.
Pro-Teen Canadian Association for Adolescent Health: 2000: 9: 18by
Program core paediatric has addressed residents. an important gap Dr. in Ian treatment Thornley, Haematology-Oncology
19.
options, allowing for adolescents to receive
Dr. Michael Peer
2nd
intensive
Place:
Rivers SM, Greenbaum RL, Goldberg E: Hospital-based adolescent
treatment for their eating disorders without
Dr. Silviu
removing substance abuse treatment: comorbidity, outcomes, and gender.
Grisaru, Nephrology Journal of Nervous and Mental Disease: April 2001: 189: 229-237.
them from their families and home communities.
Ondaatje Award to a senior resident Poster Prize:
books and chapters in books
for Over excellence the last in few clinical years, teaching the Adolescent as Substance Dr. Jacqueline Abuse Curtis, Endocrinology Katzman D, and Leonard K, Goldberg E: Challenges in adolescent health.
nominated Outreach Program by core paediatric has taken a lead role in Dr. an Christopher initiative Tomlinson, Paediatric Neonatal-Perinatal Evidence Based Medicine (Feldman W, ed). BC Decker Inc,
residents. that was launched to address a glue sniffing Medicine problem
that had been identified among several groups of
Dr. Sharon Carson, PGY4, Chief Resident
Toronto youth. The project evolved into the Glue
Toronto, Ontario: 2000
Kaufman M: Helping Your Teen Overcome Depression Key Porter
Books 2000
Pitman T, Kaufman M: Your Overweight Child Firefly Books, Toronto,
Sniffing Project 2000, and resulted in the completion of
PeRLS Awards (Paediatric
an “anti-glue sniffing” video produced by youth for
Educational Resident Lecture Series
youth. Plans were also initiated for a new web site
Award) to faculty members who
specifically designed to inform the public about glue
have demonstrated commitment to
sniffing. The committee overseeing this project continues
excellence in teaching at the
to be chaired by one of our Divisional substance abuse
Paediatric academic sessions.
treatment counsellors, and their work was recently
Dr. formally Adelle Atkinson, recognized Immunology-Allergy
by Health Canada. In their document
entitled “Preventing Substance Abuse Among Young
Dr. David Malkin, Haematology-Oncology
People: A Compendium of Best Practices,” the project
was praised as being “an exemplary Canadian program.”
Ontario: 2000
Skinner H, Maley O, Morrison M, Goldberg E: TeenNet: Using the
Internet for e-Health. Promoting Health through Organizational
Change (Skinner H, ed). Benjamin Cummings: 2001
research and investigations
A Tri-Council Workshop/Networking Program. Frappier J-Y (Project
Leader), Katzman DK, Davis C, Pierce DW, Forget J, Wilkins J, Salvy SJ: The
Canadian Institutes of Health Research, Networking
Program of the ICRS ($24,000 2000 – 2002).
Adolescent Heroin Users-Bridging the Gap to Treatment. Brands,
Bruna Leslie, Karen, Catz-Biro, Laura: Research in Psychiatry
Grants Program, The Centre for Addiction and Mental
This past year one of our Divisional physicians, Dr.
Health ($5,000 2000 – 2001).
Miriam Rossi, was promoted to the rank of full
An HIV Risk Reduction Intervention for Incarcerated Youth in
professor. In addition to her years of work within the Ontario. Goldberg E, Millson M, Read S, Rivers S, Leslie K, Wormith JS, Meen
Division, Dr. Rossi has also been the Associate Dean of
R: Ontario HIV Treatment Network (OHTN) ($584,000 1999
Student Affairs in the Faculty of Medicine at the
– 2002).
University of Toronto.
Brain Structure and Function in Adolescents with Anorexia
Nervosa. Katzman DK, Zipursky RB, Christensen BK, Young AR, Mikulis DJ:
The Divisional research activities are focused in the Ontario Mental Health Foundation ($115,745 2000 – 2002).
areas of medical complications of eating disorders, the
A Tri-Council Workshop/Networking Program. Frappier J-Y (Project
evaluation of the use of information technology for Leader), Katzman DK, Davis C, Pierce DW, Forget J, Wilkins J, Salvy SJ: The
health promotion with youth, treatment outcome and Canadian Institutes of Health Research, Networking
specific substance use studies in the area of adolescent Program of the ICRS ($24,000 2000 – 2002).
5

Adolescent Heroin Users-Bridging the Gap to Treatment. Brands,
Bruna Leslie, Karen, Catz-Biro, Laura: Research in Psychiatry
Grants Program, The Centre for Addiction and Mental
Health ($5,000 2000 – 2001).
Brain Structure and Function in Adolescents with Anorexia
Nervosa. Katzman DK, Zipursky RB, Christensen BK, Young AR, Mikulis DJ:
Ontario Mental Health Foundation ($115,745 2000 – 2002).
6

faculty Andrew Redington - Chief, Ian Adatia-(Primary appointment CCU;
secondary to Cardiology), Lee Benson, Anne Dipchand, Gil Gross,
Robert Hamilton, Lisa Hornberger, Joel Kirsh, Kyong-Jin Lee, Brian McCrindle,
Marlene Rabinovitch, Jennifer Russell, Jeffrey Smallhorn, Lori West,
Shi-Joon Yoo (Primary appointment DI; secondary to Cardiology),
part-time Robert Freedom, Paul Kantor, Anil Menon, Norman Musewe,
Lynne Nield, fellows Hayam Aboremsh, Abdulrahman Al-Moukirish, Rima Bader,
Catherine Barrea, Vishwanath Bhat, Michael Cheung, Rachel Dayan-Wald,
Gideon duMarchie-Sarvaas, Yael Garty, Fraser Golding, Mi-Jin Jung, Lillian
Lai, Suzie Lee, Stephanie Levasseur, Alejandro Peirone, Abdul Redhyan,
Farahnaz Sadegh-Beygi, Hisashi Sugiyama, Mio Taketazu, Kay Tyerman,
Emanuela Valsangiacomo, Gruschen Veldtman, Roxanne Walker
The Division of Cardiology was formally established
after World War II, and is now one of the largest and
most successful in the world. Now undergoing a period
of modest expansion of staff, the clinical portfolio of
the division is complete. Its philosophy has remained
unchanged since its inception over sixty years ago; to
provide the highest quality care in an evidence-based
environment of clinical innovation and scientific discovery.
Over the past decade, the Divisional activities, in close
collaboration with surgical and intensive care
colleagues, have contributed to our markedly improved
preoperative assessment and postoperative outcomes for
children undergoing cardiac surgery, led the field in
development of therapeutic catheter techniques, made
important contributions to our understanding of fetal
cardiac medicine, established one of the largest
paediatric cardiac transplantation centers world wide,
and has won international recognition for its
contribution in the field of epidemiology of acquired
and congenital heart disease and surgical outcomes.
Each of these areas has provided the substrate for the
large clinical research output of the Division which is
underpinned by a world class laboratory science
program. One of the most exciting clinical
developments on the horizon is the commissioning, to
open in 2003, of an integrated suite of catheter
laboratories and magnetic resonance scanning facilities.
This unique fusion will allow ‘simultaneous’ multi mode
investigation and treatment, setting the scene for MRIguided
interventional procedures in children.
Headed by Dr. Marlene Rabinovitch, the cardiovascular
research focus within the Research Institute, has made
fundamental contributions to our understanding of the
Division of CARDIOLOGY
cellular biology and molecular genetics of pulmonary
vascular bed, with recent diversification to include the
study of the fetal Myocyte, electrophysiology of the
developing heart and immunology of cardiac
transplantation. While soon to undergo a change in
leadership, it is expected that high quality basic and
translational research, with an emphasis on direct
clinical applicability, will continue in the years to come.
Finally, the Royal College accredited Paediatric
Cardiology Training Program, is the largest in Canada
and one of the largest and most sought after in North
America. As such, its fellows have populated cardiology
groups throughout the world, many going on to become
leaders of our specialty.
PUBLICATIONS
Abrams D, Derrick G, Penny DJ, Shinebourne EA, Redington AN:
Cardiac complications in children following infection with Varicella
Zoster virus. Cardiology in the Young 2001: 11: pp 647-652. SRI
Al-Shaikh AM, Abdullah MH, Barclay A, McCrindle BW: Impact of the
characteristics of patients and their clinical management in children
with homozygous familial hypercholesterolemia. Cardiology in the
Young: 2002: 12:105-112.
Azakie A, Merklinger S, McCrindle B, Van Artsdell G, Lee KJ, Benson LN,
Coles JG, Williams WG: Evolving strategies and improving outcomes
of the modified Norwood procedure: a 10-year single-institution
experience. Annals of Thoracic Surgery: 2001: 72:1349-1353.
Barolet AW, Nili N, Cheema A, Robinson R, Natarajan MK, O'Blenes S,
Li J, Eskandarian MR, Sparkes J, Rabinovitch M, Strauss BH: Arterial
elastase activity after balloon angioplasty and effects of elafin, an
elastase inhibitor. Arteriosclerosis, Thrombosis, and Vascular Biology:
2001:1269-1274.
Bennhagen RG, McLaughlin P, Benson L: Contemporary management
of children with atrial septal defects. American Journal of
Cardiovascular Drugs: 2001: 1: 409-503.
Bohn D, Benson LN: Management and treatment of pediatric
myocarditis. Pediatric Cardiovascular Drugs: 2002: 4: 171-181.
Borenstein SH, Tao K, West LJ, Chamberlain JW: Extrathymic deletion
of CD8+ alloreactive T cells in a transgenic T cell receptor model of
neonatal tolerance. Transplantation 2001: 72:1807-1816.
Cullen S, Vogel M, Deanfield JE, Redington AN: Rupture of aneurysm
of the right sinus of Valsalva into the right ventricular outflow tract:
treatment with Amplatzer atrial septal occluder. Circulation, Jan 1
2002: 105(1): pp E1-2. SRI
de Divitis M, Pilla C, Kattenhorn M, Zadinello M, Donald A, Leeson P,
Wallace S, Redington AN, Deanfield JE: Vascular dysfunction after
repair of coarctation of the aorta: impact of early surgery.
Circulation, Sep 2001: 104: pp II165-70. C
Dellgren G, Koirala B, Sakopoulus A, Botta A, Joseph J, Benson LN,
McCrindle B, Dipchand AI, Cardella CJ, Lee KJ, West LJ, VanArsdell
G, Williams WG, Coles JG: Pediatric Heart Transplantation:
improving results in high-risk patients. Journal of Thoracic and
Cardiovascular Surgery 2001:121:782-791.
Derrick GP, Josen M, Vogel M, Henein MY, Shinebourne EA,
Redington AN: Abnormalities of right ventricular long axis function
7

after atrial repair of transposition of the
great arteries. Heart, Aug 2001: 86(2): pp
203-206. SRI
Dhillon R, Josen M, Henein M, Redington
AN: Transcatheter closure of atrial septal
defect preserves right ventricular function.
Heart 2002: 87(5): pp 461-465. SRI
Dillenburg RF, Hamilton RM: Implantable
loop monitor in children. American Heart
Journal: 2002:89: 233-236.
Dipchand AI, Pietra B, McCrindle BW,
Rosebrook-Bicknell HL, Boucek MM:
Mycophenolate acid levels in pediatric
heart transplant recipients receiving
mycophenolate mofetil. Journal of Heart
and Lung Transplantation: 2001: 20: 1035-
1043.
Dipchand AI, Williams WG, Hornberger LK:
Double aortic arch with interruption
proximal to the right carotid artery,
bilateral patent ductus arteriosi, and
complex congenital heart disease. Pediatric
Cardiology: 2002: 23: 246-247.
Elias CL, Lukas A, Shurraw S, Scott J,
Omelchenko A, Gross GJ, Hnatowich M,
and Hryshko LV: Inhibition of Na+/Ca2+
exchange by KB-R7943: transport mode
selectivity and antiarrhythmic consequences.
American Journal of Physiology: 2001: 281:
H1334-1345.
Azakie A, McCrindle BW, VanArsdell G,
Benson LN, Coles J, Hamilton R, Freedom
RM, Williams RG: Extracardiac conduit
versus lateral tunnel cavopulmonary
connections at a single institution: Impact
on outcomes. Journal of Thoracic and
Cardiovascular Surgery: 2001: 122: 1219-
1228.
Golomb MR, MacGregor DL, Domi T,
Armstrong DC, McCrindle BW, Mayank S,
DeVeber GA: Early Childhood arterial
ischemic stroke with delayed diagnosis: risk
factors and outcomes. Annals of Neurology:
2001: 50:163-168.
Gou C, Ju H, Leung D, Massael H, Shi M,
Rabinovitch M: A novel vascular smooth
muscle chymase is unregulated in
spontaneously hypersensitive rats. Journal
of Clinical Investigation: 2001: 107: 703-715.
Greve G, Lab MJ, Chen R, Barron D, White
PA, Redington AN, Penny DJ: Right
ventricular distension alters monophasic
action potential duration during pulmonary
arterial occlusion in anaesthetised lambs:
evidence for arrhythmogenic right
ventricular mechanoelectrical feedback.
Experimental Physiology, Sep 2001: 86
(Pt 5): pp 651-657. C
Gupta AA, Leaker M, Andrew M, Massicotte
P, Liu L, Benson LN, McCrindle B: Safety
and outcomes of thrombolysis with tissue
plasminogen activator for treatment of
intravascular thrombosis in children.
8
Journal of Pediatrics: 2001: 139: 682-688.
Hechter SJ, Fredrikson PM, Liu P, Benson LN,
Merchant N, Veldtman G, Freeman M, Warsi
MA, Siu S, Webb G: Cardiopulmonary
exercise performance in adult survivors
with the Mustard procedure. Cardioloy in
the Young: 2001: 11: 407-414.
Hornberger LK: Congenital ductus arteriosus
aneurysm, editorial comment. Journal of
the American College of Cardiology: 2002:
39: 348-350.
Jaeggi ET, Hamilton RM, Silverman ED,
Zamora SA, Hornberger LK: Outcome of
children with fetal, neonatal or childhood
diagnosis of isolated congenital
atrioventricular block. A single institution's
experience of 30 years. Journal of the
American College of Cardiology: 2002: 39:
130-137.
Ju H, Gros R, You X, Tsang S, Husain M,
Rabinovitch M: Conditional and targeted
over expression of vascular chymase causes
hypertension in transgenic mice. Proceedings
of the National Academy of Science: 2001:
98: 7469-7474.
Justino H, Lee N, Benson LN, Nykanen DG:
Transcatheter creation of an artial septal
defect using radiofrequency perforation.
Catheterization and Cardiovascular
Intervention: 2001: 54: 83-87.
Koirala B, Van Ardsell GS, Merklinger S,
McCrindle BW, Borger MA, Caldarone C,
Coles JG, Williams WG: Extending the
usable size range of homografts in the
pulmonary circulation: Outcome of
“bicuspid homografts”. Annals of Thoracic
Surgery: 2002: 73: 866-869.
LeBlanc JG, Russell JL, Potts JE, Deagle ML,
Sett SS: Surgical closure of secundum atrial
septal defects-the cutting edge? Asian
Cardiovascular and Thoracic Annals: 2001:
9: 192-195.
Lee KJ, Humpl T, Hashmi A, Nykanen DG,
Benson LN: Restored patency of aortopulmonary
shunts after stent implantation.
American Journal of Cardiology: 2001: 88:
325-328.
Maeno YV, Kamenir SA, Sinclair B, van der
Velde ME, Smallhorn JF, Hornberger LK:
Prenatal features of ductus arteriosus
constriction and restrictive foramen ovale
in d-transposition of the great artries.
Circulation: 2002: 99: 1209-1214.
McCrindle BW: Considerations in the
appraisal of mortality associated with
congenital cardiac lesions. Seminars in
Thoracic and Cardiovascular Surgery,
Pediatric Cardiac Surgical Annual: 2001: 4:
244-255.
McCrindle BW: Myocardial bridging o f the
left anterior descending coronary artery in
children with hypertrophic
cardiomyopathy. Journal of the American
College of Cardiology: 2001: 38: 921-922.
McCrindle BW, Blackstone EH, Williams WG,
Sittiwangkul R, Spray TL, Azakie A, Jonas
RA: Are outcomes of surgical versus
transcatheter balloon valvotomy equivalent
in neonatal critical aortic stenosis?
Circulation: 2001: 104 I: I-152-I-15.
Morgan H, Khan I, Hashmi A, Herbert D,
McCrindle BW, Balfe JW: Ambulatory blood
pressure monitoring and cardiac
hypertrophy after pediatric renal
transplantation. Pediatric Nephrology:
2001: 16: 843-847.
Nield LE, Silverman ED, Taylor GP,
Smallhorn JF, Mullen BBM, Silverman NH,
Finley JP, Law YM, Human DG, Seaward
PG, Hamilton RM, Hornberger LK:
Maternal anti-Ro and anti-La antibody
induced primary endocardial fibroelastosis.
Circulation 2002: 105: 843-848.
O'Blenes CA, Kinnear C, Rabinovitch M:
TNF-alpha induces fibronectin synthesis in
coronary artery smooth muscle cells by a
NO-dependent post-transcriptional
mechanism. Circulation Research: 2001:
89: 26-32.
O'Blenes SB, Fischer S, McIntyre B, Keshavjee
S, Rabinovitch M: Hemodynamic
unloading leads to regression of pulmonary
vascular disease in rats. Journal of Thoracic
and Cardiovascular Surgery: 2001: 121:
279-289.
Okubo M, Benson LN: Intracardiac stents in
congenital heart disease. Current Opinion
in Cardiology Vol 16: 2001: 84-91.
Rabinovitch M: Linking a serotonin
transporter polymorphism to vascular
smooth muscle proliferation in patients
with primary pulmonary hypertension.
Journal of Clinical Investigation: 2001: 108:
1109-1111.
Rastegari M, Redington AN, Sullivan ID:
Influence of the introduction of Amplatzer
device on the interventional closure of
defects within the oval fossa in children.
Cardiology in the Young, Sep 2001: 11(5):
pp 521-525. C
Sanatani S, Peirone A, Chiu C, Human DG,
Gross GJ, Hamilton RM: Use of implantable
loop recorder in the evaluation of children
with congenital heart disease. American
Heart Journal 2002: 143: 366-372.
Sanatani S, Saul JP, Walsh EP, Gross GJ:
Spontaneously terminating apparent
ventricular fibrillation during
transesophageal electrophysiologic testing
in infants with Wolff-Parkinson-White
Syndrome. PACE: 2001: 24: 1816-1818.
Sittiwangkul R, Ma RY, McCrindle BW, Coles
JG, Smallhorn JF: The echocardiographic
assessment of obstructive lesions in
atrioventricular septal defect. Journal of the
American College of Cardiology: 2001: 38:

253-261.
Siu SC, Colman JM, Sorensen S, Smallhorn
JF, Farine D, Amankwah KS, Spears JC,
Sermer M: Adverse neonatal and cardiac
outcomes are more common in pregnant
women with cardiac disease. Circulation:
2002: 105: 2179.
Sokol J, Bohn D, Lacro RV, Ryan G,
Stephens D, Rabinovitch M, Smallhorn JF,
Hornberger LK: Fetal pulmonary artery
diameters and their association with lung
hypoplasia and postnatal outcome in
congenital diaphragmatic hernia. American
Journal of Obstetrics and Gynaecology:
2002: 186: 1085-1090.
Suto F, Cahill SA, Wilson GJ, Hamilton RM,
Greenwald I, Gross GJ: A novel rabbit
model of variably compensated complete
heart block. Journal of Applied
Physiology: 2002: 92: 1199-1204.
Tse SML, Silverman ED, McCrindle BW,
Yeung RSM: Early treatment with
intravenous immunoglobulin in patients
with Kawasaki disease. Journal of
Pediatrics: 2002: 140: 450-455.
Valsangiacomo ER, Smallhorn JF: Prenatal
diagnosis of aortopulmonary window by
fetal echocardiography. Circulation: 2002:
105: e192.
Vogel M, Schmidt MR, Kristiansen SB,
Cheung M, White PA, Sorensen K,
Redington AN: Validation of myocardial
acceleration during isovolumic contraction
as a novel non-invasive index of right
ventricular contractility: comparison with
ventricular pressure-volume relations in
an animal model. Circulation, Apr 9
2002: 105(14): pp 1693-1699. SRI
West LJ, Pollock-Barziv SM, Dipchand AI,
Lee KJ, Cardella CJ, Rebeyka IM, Benson
LN, Coles JG: ABO-imcompatible heart
transplantation in infants – article
accompanied by editorial. New England
Journal of Medicine 2001:344:793-800.
Williams WG, McCrindle BW: Practical
experience with databases for congenital
heart disease: A registry versus an
academic database. Semin Thorac
Cardiovasc Surg Pediatr Card Surg Annul:
2002: 5: 132-142.
Zaidi SHE, You X-M, Ciura S, Husain M,
Rabinovitch M: Overexpression of the serine
elastase inhibitor elafin protects transgenic
mice from hypoxic pulmonary hypertension.
Circulation: 2001: 105: 516-521.
books & book chapters
Hornberger LK, Barrea C: Diagnosis,
Natural History, and Outcome of Fetal
Heart Disease. In: Seminars in Thoracic
and Cardiovascular Surgery: Pediatric
Cardiac Surgery Annual 2001 (Coles JG,
Williams WG, eds). WB Saunders,
Philadelphia, PA: 2001: 229-243.
Rabinovitch M: Diseases of the pulmonary
vasculature. In: Textbook of Cardiovascular
Medicine (Topol EJ, ed). Lippincott-
Williams and Wilkins, Philadelphia: 2001.
Rabinovitch M: Pathology of Pulmonary
Hypertension. Progress in Pediatric
Cardiology. Elsevier Science Ltd. Ireland,
2001, 223-247.
Rabinovitch M: Tissue remodeling and
extracellular matrix proteins. In: Transplant-
Associated Coronary Artery Vasculopathy.
(Dr. Marlene I Rose, eds) RG Landes
Publisher, Georgetown, TX. 2001.
Rabinovitch M: Pathophysiology of
pulmonary hypertension: Chapter in
Moss and Adams Heart Disease in Infants,
Children, and Adolescents.
(Emmanouilides GC, Riemenschneidier
TA, Allen HD, Gutgesell HP eds) Williams
and Wilkins, Baltimore. (6th edition)
vol. II, 2001.
Rabinovitch M: Monocrotaline-induced
pulmonary hypertension in rats. In:
Vascular Disease and Injury (Dr. C. Rogers
and Dr. D. Simon, eds) Humana Press,
Totawa, NJ. 2001.
Rabinovitch M: Pathobiology of pulmonary
hypertension: Extracellular Matrix in
Clinics in Chest Medicine, Pulmonary
Hypertension. (Dr. S. Rich and Dr. V.
McLaughlin, eds) WB Saunders Company,
St. Louis, MO. 2001.
Rabinovitch M: Pathology of pulmonary
hypertension. In: Progress in Pediatric
Cardiology Elsevier Science Ltd., Ireland:
2001: 223-247.
research and investigations
A study of the safety, tolerance
and efficacy of palivizumab (MEDI-
493, “Synagis”) for prophylaxis of
respiratory syncytial virus in
children with congenital heart
disease: PROTOCOL MI-CP048. Lee
KJ (Principal Site Investigator): MedImmune
($61,800 2000 - 2002).
Allograft tolerance induction during
immaturity. West, L.J: The Physicians'
Services Incorporated Foundation (per
year) ($81,000 2001 - 2003).
AML1, Mts 1, progression and
regression of pulmonary vascular
disease. Rabinovitch M: Heart and Stroke
Foundation of Canada ($179,327 2001 -
2006).
Anticoagulation Post-Fontan/
Closure of ASD's - The Pediatric
Heart Disease Clinical Research
Network. McCrindle BW, Williams WG,
Benson L, Smallhorn J, Shi-Joon Yoo, Hamilton
R, Massicotte P, West L, Rabinovitch M, Bohn D,
Holtby H: The National Institutes of
Health ($2,199,976 2001 - 2006).
Application of fetal
electrocardiography to fetal
cariology. Hamilton R: Heart and Stroke
Foundation of Ontario ($91,401 2001).
B1 integrins and the IGF2-IGF1
receptor system in fetal cardiac
myocyte proliferation: Regulatory
role for the nuclear transcription
factor Sp1. Hornberger LK, None: Grant-
In-Aid, Heart and Stroke Foundation of
Ontario ($116,168 2000 - 2002).
B1 integrins and the IGF2-IGF1
receptor system in fetal cardiac
myocyte proliferation: regulatory
role for the nuclear transcription
factor Sp1. Hornberger LK, None: Heart
and Stroke Foundation of Canada, Research
Scholarship ($250,000 2001 - 2006).
Dobutamine/atropine stress
echocardiography in paediatric
heart transplant recipients for the
assessment of post-transplant
coronary artery disease. Dipchand, AI,
McCrindle, B, West, LJ: The Hospital for Sick
Children Seed Grant Competition (2 year
pilot grant) ($32,000 2002 - 2004).
Elastase myocardial remodelling
and progenitor cells. Rabinovitch M:
Medical Research Council of Canada
($105,000 2000 - 2005).
Etiology of the hemodynamic and
placental changes observed in
twin-to-twin transfusion syndrome -
from the clinical manifestations to
the cellular mechanisms. Hornberger
LK, Barrea C, Kingdom J, Ryan G: The
Physicians' Services Incorporated
Foundation Grant ($103,000 2001 - 2003).
Fetal electrocardiography,
patient-based research. Coates A,
Hamilton RM: The Hospital for Sick
Children ($35,605 2001).
Fetal response to maternal
9

exercise in pregnant women with
placental insufficiency. Hornberger LK,
Simchen M, Allen V, Kingdom J, Smallhorn J,
Coates A: The Physicians' Services
Incorporated Foundation Fellow Grant
($120,660 2001 - 2003).
Functional and humoral correlates
during the first 24 hours after
cardiopulmonary bypass
procedures in children. Dr. Andrew N.
Redington: British Heart Foundation
(£154,000 2000 - 2002).
Haemodynamic predictors of poor
functional outcome after Fontan
procedures. Dr. Andrew N. Redington, Prof.
M. deLeval, Prof. J. Deanfield: British Heart
Foundation (£167,000 2000 - 2002).
Interdisciplinary program in
cardiovascular development and
disease. Rabinovitch M: Canadian
Institute of Health Research ($268,931
2001 - 2006).
LC-3, apolipoprotein D and
mechanisms of neointimal
formation. Rabinovitch M: Canadian
Institute of Health Research ($169,352
2001 - 2006).
Mechanisms of cardiac allograft
tolerance induced during
immaturity. West LJ: The Heart and
Stroke Foundation of Ontario (per year)
($65,000 2001 - 2003).
Mortality and outcomes of
tetralogy of fallot in an adult
cohort. McCrindle BW, Gatzoulis M, Webb G,
To T: Heart and Stroke Foundation of
Canada ($290,718 1999 - 2002).
Ms Natalia Lobach. West LJ: Samuel
Lunenfeld Summer Student Program
($9,999 2001).
Neurodevelopmental outcome
after neonatal cardiac surgery.
Sananes R, McCrindle BW, Kelly E, Hornberger L:
Heart and Stroke Foundation of Ontario
($230,090 1998 - 2001).
Operating funds. West LJ: The
Hospital for Sick Children Research
Institute ($9,999 1998 - 2001).
Pharmacokinetic analysis of
basiliximab as induction
10
immunotherapy in paediatric
heart transplant patients (Research
grant - $22,000 prepatory grant). West,
LJ: Novartis Canada Inc. ($22,000 2002).
Predictors of neurodevelopmental
outcomes after neonatal
cardiopulmonary bypass. Senenas R,
Hornberger L, McCrindle B, Kelly E, Bohn D,
Williams WG: Grant in Aid (Renewal)
Heart and Stroke Foundation of Ontario
($124,822 2001 - 2003).
Project Director Ontario consortium for
cardiac imaging-combined industry and
government grant for 5 years $4000,000.
Three dimensional echocardiography:
The change in left A-V valve
morphology following AVSD repair.
Contrast echocardiography in
Paediatrics-role in the evaluation of
bidirectional cavopulmonary shunts
and other defects (2001-2005).
Smallhorn JF: Ontario consortium for
cardiac imaging-combined industry and
government grant. ($400,000 2001 - 2005).
Renewal - Maternal autoantibodies
and congenital atrioventricular
block (US Funds). Hornberger LK,
Silverman E, Hamilton R, Wyatt P, Feldman B,
Ryan G, Windrim R: March of Dimes
Research Grant ($261,429 2000 - 2003).
Right ventricular function in heart
transplantation. Dr. Andrew N.
Redington, Mr. S. Large: British Heart
Foundation (£135,927 2000 - 2002).
Salary support for post-doctoral fellow,
Dr Frank Fan - Restracomp funding.
West, LJ: Hospital for Sick Children
Research Institute ($9,999 2002 - 2003).
Ventriculo-vascular interaction in
children after heart
transplantation. Dr. Andrew N.
Redington: Garfield-Weston Foundation
(£86,000 2000 - 2001).

faculty Rosanna Weksberg– Chief, Melanie Bedford, David Chitayat, Joe T.R.
Clarke, Annette Feigenbaum, Stephen Meyn, Marjan Nezarati, Ahmad S. Teebi,
Sheila Unger, part time staff Alan Berzen, Karen Chong, Leona Fishman,
clinical fellows Pranesh Chakraborty, Aneal Khan, Komudi Siriwardena
The Division of Clinical and Metabolic Genetics is
recognized nationally and internationally for its
contributions to clinical and basic genetics. Recent
clinical initiatives have included the development of
clinics such as the Skeletal Dysplasia Clinic and the
Metabolic Bone Disease Clinic, operating in conjunction
with the Department of Orthopaedics and Division of
Endocrinology respectively, as well as a Metabolic
Transition Clinic to prepare adolescent geneticmetabolic
patients for the changeover from a paediatric
to an adult health care facility.
Research endeavours in the Division are actively
expanding in several areas including appraisal of
population screening for familial dysautonomia and
Canavan disease, trials of enzyme replacement therapies
for selected metabolic disorders and studies of the role
of genomic imprinting in overgrowth syndromes. A
database has been established to track genetic diseases
and mutations in the Arab population. The third
Annual Starbucks Clinical Genetics Research
Studentship Award was won by Susan Hiraki who is
studying patient perceptions regarding the consent form
for DNA Testing/Banking.
The Division has also participated in numerous
educational activities for physicians and other health
care practitioners. The Annual Prenatal and Medical
Genetics Update organized by Dr. Chitayat took place in
May 2002. The Division’s participation in Paediatric
Update was organized by Dr. A. Teebi. The Division also
held a Divisional Retreat in May 2002.
The MSc Program in Genetic Counselling graduated its
third class of students. All graduates of this Program
have been successful in gaining employment in their
chosen profession. This program is a collaborative
venture involving the Division of Clinical and
Metabolic Genetics at HSC and the Department of
Molecular and Medical Genetics, University of Toronto.
Division 2001-2002 of CLINICAL AWARDS GENETICS
publications
Akoury HA, Windrim R, Hannah ME, Seaward G, Chitayat D, Thomas
M: Patients' acceptance of second-trimester pregnancy termination
methods. Obstetrics and Gynecology: 2002: 99: S84.
Al-Sannaa N, Forrest CR, Teebi AS: Trigonomicrocephaly, severe
micrognathia, large ears, atrioventricular septal defects, symmetrical
cutaneous syndactyly of hands and feet, and multiple cafe-au-lait
spots: anew acrocraniofacial dysostosis syndrome? American Journal
of Medical Genetics: 2001: 101: 279 - 282.
Barr CL, Best L, Weksberg R: Linkage study in families with posterior
helical ear pits and Wiedemann-Beckwith syndrome. American
Journal of Medical Genetics: 2001: 104: 120-126.
Boerkoel CF, Takashima H, Garcia CA, Olney RK, Johnson J, Berry K,
Russo P, Kennedy S, Teebi AS, Scavina M, Williams LL, Mancias P,
Butler IJ, Krajewski K, Shy M, Lupski JR: Charcot-Marie-Tooth disease
and related neuropathies: mutation distribution and genotypephenotype
correlation. Annals of Neurology: 2002: 51: 190-201.
Boerkoel CF, Takashima H, John J, Yan J, Stankiewicz P, Rosenbarker L,
Andre JL, Bogdanovic R, Burguet A, Cockfield S, Cordeiro I, Frund S,
Illies F, Joseph M, Kaitila I, Lama G, Loriat C, McLeod DR, Milford D,
Petty EM, Rodrigo F, Saraiva JM, Schmidt B, Smith GC, Spranger J,
Stein A, Thiele H, Weksberg R, Lupski JR, Stockton DW: Mutant
chromatin remodeling protein SMARCAL1 causes Schimke
immunosseous dysplasia. Nature Genetics: 2002: 30: 215-220.
Brown NF, Mullur RS, Subramanian I, Esser V, Bennett MJ, Saudubray
JM, Feigenbaum AS, Kobari JA, Macleod PM, McGarry JD, Cohen JC:
Molecular characterization of L-CPT I deficiency in six patients:
insights into function of the native enzyme. Journal of Lipid
Research: 2001: 42: 1134-1142.
Cao JP, Hamm U, Meyn MS, Eckardt-Schupp F, Fritz E: TEL1 from S.
cerevisiae suppresses ionizing radiation-induced chromosome
aberrations in ataxia-telangiectasia cells without affecting cell cycle
checkpoints. Radiation and Environmental Biophysics: 2001: 40:
309-315.
Choong K, Clarke JT, Cutz E, Pollit RJ, Olpin SE: Lethal cardiac
tachyarrhythmia in a patient with neonatal carnitine-acylcarnitine
translocase deficiency. Pediatric Developmental Pathology: 2001: 4:
573-579.
Chow GC, Clarke JT, Banwell BL: Late-onset GM2 gangliosidosis
presenting as burning dysesthesias. Pediatric Neurology: 2001: 25:
59-61.
Chun K, Teebi AS, Jung JH, Laframboise R, Nakabayashi K, Scherer SW,
Ray PN, Teshima I: Genetic analysis of patients with the Saethre-
Chotzen phenotype. American Journal of Medical Genetics: 2002:
110: 136-143.
Clarke JTR, Amato D, Deber R: Managing public payment for highcost,
high-benefit treatment: Enzyme replacement therapy for
Gaucher's disease in Ontario. Canadian Medical Association Journal:
2001: 165: 595-596.
Clarkson B, Pavenski K, Dupuis L, Kennedy S, Meyn S, Nezarati MM,
Nie G, Weksberg R, Withers s, Quercia N, Teebi AS, Teshima I:
Detecting rearrangements in children using subtelomeric FISH and
SKY. American Journal of Medical Genetics: 2002: 107: 267-274.
Dupuis L, Nezarati MM: Neurofibromatosis Type I as a model of
autosomal dominant inheritance. Pediatric Dermatology: 2001: 18:
445-447.
Kennedy SJ, Adatia I, Teshima I, Teebi AS: An inherited duplication,
Dup (8) (p23.1) pat, in a father and daughter with congenital heart
defects. American Journal of Medical Genetics: 2001: 104: 79 -80.
Koren G, Cohn T, Chitayat D, Kapur B, Remington G, Reid DM,
Zipursky RB: Use of atypical antipsychotics during pregnancy and
11

the risk for neural tube defects in infants.
The American Journal of Psychiatry: 2002:
159: 136-137.
Lazier K, Chow EW, Abdel-Malik P, Scutt L,
Weksberg R, Bassett AS: Low platelet count
in 22q11 deletion syndrome subtype of
schizophrenia. Schizophrenia Research:
2001: 50: 177-180.
Li M, Shuman C, Fei Y-L, Cutiongco E,
Bender HA, Stevens C, Wilkins-Haug L,
Day-Salvatore D, Yong SL, Geraghty MT,
Squire J, Weksberg R: GPC3 mutation
analysis in a spectrum of patients with
overgrowth expands the phenotype of
Simpson-Golabi-Behmel syndrome.
American Journal of Medical Genetics:
2001: 102: 161-168.
Nakabayashi K, Fernandez BA, Teshima I,
Shuman C, Proud V, Curry CJR, Chitayat D,
Grebe T, Ming J, Oshimura M, Meguro M,
Mitsuya K, Deb-Rinker P, Herbrick JA,
Weksberg R, Scherer SW: Molecular genetic
studies of human chromosome 7 in Russell-
Silver syndrome. Genomics: 2002: 79:
186-196.
Nezarati MM, Loeffler J, Yoon G, MacLaren L,
Fung E, Snyder F, Ultermann G, Graham
GE: A novel mutation in the D7-sterol
reductase gene associated with a variable
phenotype in three Lebanese siblings with
Smith-Lemli-Opitz syndrome. American
Journal of Medical Genetics: 2002: 110:
103-108.
Osborne LR, Li M, Pober B, Chitayat D,
Bodurtha J, Mandel A, Costa T, Grebe T,
Cox S, Tsui L, Scherer S: 1.5 million-base
pair inversion polymorphism in families
with Williams-Beuren syndrome. Nature
Genetics: 2001: 29: 321-325.
Pace JM, Chitayat D, Atkinson M, Wilcox
WR, Schwarze U, Byers PH: A single amino
acid substitution (D1441Y) in the carboxylterminal
propetide of the proalpha 1 (I)
chain of type I collagen results in a lethal
variant of osteogenesis imprefecta with
features of dense bone diseases. Journal of
Medical Genetics: 2002: 39: 23-29.
Quercia N, Teebi AS: Craniosynostosis,
ectopia lentis, and congenital heart defects:
Farther delineation of an autosomal
dominant syndrome with incomplete
penetrance. American Journal of Medical
Genetics: 2002: 107: 38-42.
Scutt LE, Chow EWC, Weksberg R, Honer
WG, Bassett AS: Patterns of dysmorphic
features in schizophrenia. American Journal
of Medical Genetics: 2001: 105: 713-723.
Sgro MD, Barozzino T, Mirghani HM, Sermer
M, Moscato L, Akoury H, Koren G,
Chitayat D: Pregnancy outcome post renal
transplantation. Teratology: 2002: 65: 5-9.
Shah V, Friedman S, Moore AM, Platt BA,
Feigenbaum AS: Selective screening for
12
neonatal galactosemia: an alternative
approach. Acta Paediatrica: 2001: 90:
948-949.
Siegel-Bartlet J, Levin A, Kennedy SJ, Teebi
AS: Craniofacial anomalies, cataracts,
congenital heart disease, sacral neural tube
defects, growth and developmental
retardation in two sisters: A new MCA/MR
syndrome. Journal of Medical Genetics:
2002: 39: 145-8.
Smith AC, Squire JA, Thorner P, Zielenska M,
Shuman C, Grant R, Chitayat D, Nishikawa
JL, Weksberg R: Association of alveolar
rhabdomyosarcoma with the Beckwith-
Wiedemann syndrome. Pediatric and
Development Pathology: 2001: 4: 550-558.
Sobacchi C, Frattini A, Orchard P, Porras O,
Tezcan I, Andolina M, Babul-Hirji R, Baric I,
Canham N, Chitayat D, Dupuis-Girod S,
Ellis I, Etzioni A, Fasth A, Fisher A,
Gerritsen B, Gulino V, Horwitz E, Klamroth
V, Lanino E, Mirolo M, Musio A, Matthijs
G, Nonomaya S, Notarangelo LD, Ochs HD,
Superti-Furga A, Valiaho J, van Hove JL,
Vihinen M, Vujic D, Vezzoni P, Villa A: The
mutational spectrum of human malignant
autosomal recessive osteopetrosis. Human
Molecular Genetics: 2001: 10: 1767-1773.
Teebi AS, Kennedy S, Chun K, Ray PN: Severe
and mild phenotypes in Pfeiffer Syndrome
with splice acceptor: Report of two novel
mutations in exon IIIc of FGFR2. American
Journal of Medical Genetics: 2002: 107:
43 -47.
Teebi AS, Porter C, Cuticchia J: Arab Genetic
Diseases Data Base (AGDDB): A population
specific clinical and mutation database.
Human Mutation: 2002: 19: 615-621.
Unger S, Hecht Jacqueline T:
Pseudoachondroplasia and multiple
epiphyseal dysplasia: New etiological
developments. American Journal of
Medical Genetics: 2001: 106: 244-250.
Unger S, Korkko J, Krakow D, Lachman RS,
Rimoin DL, Cohn DH: Double
heterozygosity for pseudoachondroplasia
and spondyloepiphyseal dysplasia
congenita. American Journal of Medical
Genetics: 2001: 102: 140-146.
Unger S, Le Merrer M, Meinecke P, Chitayat
D, Rossi A, Superti-Furga A: New dysplasia
or achondrogenesis type 1B? The
importance of histology and molecular
biology in delineating skeletal dysplasias.
Pediatric Radiology: 2001: 31: 893-894.
van Bokhoven H, Hamel BC, Bamshad M,
Sangiorgi E, Gurrieri F, Duiijf PH,
Vanmolkot KR, van Beusekokm E, van
Beersum SE, Celli J, Merkx GF, Tenconi R,
Fryns JP, Verloes A, Newbury-Ecob RA,
Raas-Rotschild A, Majewski F, Beemer FA,
Janecke A, Chitayat D, Crisponi G, Kayserili
H, Yates JR, Neri G, Brunner HS: p63 Gene
mutations in eec syndrome, limb-mammary
syndrome, and isolated split hand-split foot
malformation suggest a genotypephenotype
correlation. American Journal of
Human Genetics: 2001: 69: 481-492.
Weksberg R, Nishikawa J, Caluseriu O, Fei YL,
Shuman C, Wei C, Steele L, Cameron J,
Smith A, Ambus I, Li M, Ray PN, Sadowski
P, Squire J: Tumor development in the
Beckwith-Wiedemann syndrome is
associated with a variety of constitutional
molecular 11p15 alterations including
imprinting defects of KCNQ1OT1. Human
Molecular Genetics: 2001:10: 2989-3000.
Weksberg R, Shuman C, Caluseriu O, Smith
AC, Fei YL, Nishikawa J, Stockley TL, Best
L, Chitayat D, Olney A, Ives E, Schneider A,
Bestor TH, Li M, Sadowski P, Squire J:
Discordant KCNQ1OT1 imprinting in sets
of monozygotic twins discordant for
Beckwith-Wiedemann syndrome. Human
Molecular Genetics: 2002:11: 1-9.
Winsor S, Concacher S, Myles-Reid D,
Chitayat D, Johnson J: Long-term outcome
of fetuses with increased nuchal
translucency and normal karyotype.
American Journal of Obstetrics and
Gynecology Supplement: 2001: 185: S249.
Yoon G, Graham G, Weksberg R, Gaul HP,
DeBaun MR, Coppes MJ: Neuroblastoma in
a patient with the Beckwith-Wiedemann
syndrome. Medical and Pediatric Oncology:
2002: 38: 193-199.
books and book chapters
Chitayat D, Hodgkinson K: Prenatal
diagnosis in clinical practice. In: Maternal-
Fetal Toxicology (Koren G, ed). Marcel
Dekker Inc, New York: 2001: 653-672.
Cohen MM Jr, Neri G, Weksberg R:
Overgrowth Syndromes (Cohen MM Jr,
Neri G, Weksberg R, eds). Oxford
University Press, New York: 2002.
Nulman I, Bar-Oz B, Laslo D, Fried S,
Chitayat D, Koren G: Fetal malformations
associated with drugs and chemicals.
Maternal-Fetal Toxicology (Koren G, ed).
Marcel Dekker, Inc., New York: 2001:
673-696.
Rimoin DL, Lachman RS, Unger S:
Chondrodysplasias. In: Emery & Rimoin's
Principles and Practice of Medical Genetics
- 4th Edition (Rimoin DL, Connor JM,
Pyeritz RE, Korf B, eds). Churchill
Livingstone. An Imprint of Harcourt
Publishers Limited, London: 2002: 4071-
4116.

esearch investigations
A screening strategy for a genetic
subtype of schizophrenia. Bassett AS,
Weksberg R, Chow EWC, Brzustowicz L, Siu S,
Zipursky R, Husted J: Medical Research
Council of Canada ($338,496 2000 - 2003).
ALID-06-01:A multicenter,
multinational open-label extension
study of the safety and efficacy of
recombinant human alpha-Liduronidase
in patients with
mucopolysaccharidosis I (MPS I).
Clarke JTR, Mahuran JJ: Biomarin/Genzyme
LLC ($207,578 2001 - 2002).
Canadian centre for applied cancer genetics.
Malkin D, Weksberg R: Canadian
Foundation for Innovation ($1,720,000
2002 - 2006).
Development of Fabry-specific
disease-severity questionnaire for
patients. Clarke J: Transkaryotic
Therapies Inc. ($76,344 2002 - 2004).
DSB repair, telomeres and the
chromosome instability syndromes.
Meyn MS: National Cancer Institute of
Canada ($136,000 2001 - 2004)
Elucidation of the pathways
involved in degradation of mutant
lysosomal enzymes. Mahuran D, Clarke
JTR, Brown E, Callahan J, Withers S: PENCE
Protein Science Research Funding
($480,000 2002 - 2005).
Genomic imprinting in a tumor
predisposing region of
chromosome band 11p15. Weksberg
R, Squire J: National Cancer Institute of
Canada ($58,879 2001 - 2002).
Mechanisms for the degradation
and rescue of mutant lysosomal
enzymes. Clarke JTR, Mahuran D, Callahan
JW, Lukacs G: Sanfilippo Children's Research
Foundation ($123,400 2001 - 2003).
Physical and psychiatric phenotype
of adults with congenital heart
defects and schizophrenia. Bassett
AS, Weksberg R: Ontario Mental Health
Foundation ($60,000 1999 - 2001).
Potential predictor of
Schizophrenia in a genetic high
risk sample: Ontario project. Chow
E, Bassett A, Weksberg R, Zipursky R, Mikulis D:
Ontario Mental Health Foundation (Bill
Jefferies Schizophrenia Endowment
Fund) ($80,000 2002 - 2003).
TKT010:A Phase III randomized,
double-blind, placebo-controlled,
multi-center clinical trial of alphagalactosidase.
A replacement
therapy in patients with Fabry
disease. Clarke JTR, Iwanochko M, Wherrett J:
Transkaryotic Therapies Inc. ($165,568
2001 - 2002).
13

faculty Shinya Ito – Chief, Patricia Harper, Gideon Koren, Margaret Thompson,
Sylvain Baruchel (cross-appointee), Denis Scolnik (cross-appointee), Anna Taddio
(cross-appointee) part time Lidia Derewlany, Tom Einarson, Neil Shear,
Sheila Jacobson, Rocco Gerace, Bonnie Stevens, Sunita Vohra
clinical fellows Zinaida Levichek, Radinka Boskovic, Irena Nulman,
Eran Kozer, Ran Goldman, Raanan Cohen-Kerem, Tommy Ho, Yelena Potylitsina
research fellows Adriana Costei, Wen Gao, Yaron Yagev
residents Savithiri Ratnapalan, Maria Valois
The Division of Clinical Pharmacology and Toxicology
focuses on a wide range of drug-related issues in
pediatrics. The division is one of the largest and the
most active pediatric pharmacology programs
internationally. Our major clinical activities include a
consultation service, the Motherisk program (the
counseling and information center for drug and other
exposures during pregnancy and lactation), and the
Ontario Regional Poison Information Center. The
division is one of the two major training sites of the
Royal College-accredited Clinical Pharmacology
Residency program of the University of Toronto. Our
research programs focus on drug metabolizing enzymes
and its regulation, drug transporters, placental and
mammary gland drug transport and metabolism, and
reproductive toxicology and teratology.
publications
Addis A, Moretti ME, Ahmed Syed F, Einarson TR, Koren G: Fetal
effects of cocaine: An updated meta-analysis. Reproductive
Toxicology: 2001: 15: 341-369.
Aleksa K, Ito S, Koren G: Developmental renal tubular toxicity: A
hypothetical and experimental approaches. Current Therapeutic
Research: 2001: 62: 930-941.
Aleksa K, Woodland C, Koren G: Young age and the risk for
ifosfamide-induced nephrotoxicity: A critical review of two opposing
studies. Pediatric Nephrology: 2001: 16: 1153-1158.
Anand KS, Abu-Saad HH, Aynsley Green A, Bancalari E, Benini F,
Champion GD, Craig KD, Dangel T, Fournier-Charrier E, Franck LS,
Eckstein Grunau R, Hertel SA, Jacq Z, Aigrain E, Jorch G, Kopelman
BI, Koren G, Larrson B, Marlow N, McIntosh N, Ohlsson A, Olsson
G, Porter F, Richter R, Stevens B, Taddio A: Treating pain in the
newborn. Archives of Pediatrics and Adolescent Medicine: 2001:
155: 173-180.
Atanackovic G, Navioz Y, Moretti ME, Koren G: The safety of higher
than standard dose of doxylamine-pyridoxine (Diclectin) for nausea
and vomiting of pregnancy. Journal of Clinical Pharmacology: 2001:
41: 842-845.
Atanackovic G, Wolpin J, Koren G: Determinants of the need for
hospital care among women with nausea and vomiting of
pregnancy. Clinical and Investigative Medicine: 2001: 24: 90-93.
Bailey B, Lalkin A, Kapur BM, Koren G: Is chronic poisoning with
acetaminophen in children a frequent occurrence in Toronto?
Canadian Journal of Clinical Pharmacology: 2001: 8: 96-101.
Division of CLINICAL PHARMACOLOGY
Bar-Oz B, Berkovitch M, Ford-Jones L, Koren G: Congenital
cytomegalovirus infection. Is there a breakthrough? Canadian
Family Physician: 2001: 47: 1179-1181.
Bar-Oz B, Hackman R, Einarson T, Koren G: Pregnancy outcome after
cyclosporine therapy during pregnancy: a meta-analysis.
Transplantation: 2001: 71: 1051-1055.
Boskovic R, Klein J, Woodland C, Karaskov T, Koren G: The role of the
placenta in variability of fetal exposure to cocaine and
cannabinoids: a twin study. Canadian Journal of Physiology and
Pharmacology: 2001: 79: 942-945.
Brunner M, Guo W, Mitchell GF, Buckett PD, Nerbonne JM, Koren G:
Characterization of mice with a combined suppression of 1 (to) and
1(K, slow). American Journal of Physiology. Heart and Circulatory
Physiology: 2001: 281: H1201-1209.
Carver V, Coyle B, Koren G, Lavigne S, Martinez L, Robertson J, Polifka
J, Stepanuk K: A call for action prevention of fetal exposure to
isotretoin. A position paper by the organization of teratology
information services public affairs committee. Reproductive
Toxicology: 2001: 15: 729.
Costei AM, King SM, Koren G: Update on perinatal HIV. Canadian
Family Physician: 2001: 47: 2221-2222.
Einarson A, Fatoye B, Sarkar M, Lavigne SV, Brochu J, Chambers C,
Mastoiacovo P, Addis A, Matsui D, Schuler L, Einarson TR, Koren G:
Pregnancy outcome following gestational exposure to venlafaxine; a
muliticenter prospective controlled study. American Journal of
Psychiatry: 2001: 158: 1728-1730.
Einarson A, Selby P, Koren G: Abrupt discontinuation of psychotropic
drugs during pregnancy: fear of teratogenic risk and impact of
counselling. Journal of Psychiatry Neurosciences: 2001: 26: 44-48.
Einarson A, Selby P, Koren G: Discontinuing antidepressants and
benzodiazepines upon becoming pregnant: Beware of the risks of
abrupt discontinuation. Canadian Family Physician: 2001: 47:
489-490.
Einarson A, Shuhaiber S, Koren G: Effects of antibacterials on the
unborn child; what is known and how should this influence
prescribing. Paediatric Drugs: 2001: 3: pp 803-816.
Fouladi M, Stempak D, Gammon J, Klein J, Grant R, Greenberg ML,
Koren G, Baruchel S: Phase 1 trial of twice daily regiment of
amifostine with ifosfamide, carboplatin, and etoposide
chemotherapy in children with refractory carcinoma. Cancer: 2001:
92: 914-923.
Gallo M, Koren G: Can herbal products be used safely during
pregnancy ? Focus on echinacea. Canadian Family Physician: 2001:
47: 1727-1728.
Geshundheit B, Cividalli G, Freeman A, Yatziv S, Koren G, Baruchel S:
Cyclosporin A in the treatment of refractory immune
thrombocytopenia purpura in children. European Journal of
Haematology: 2001: 66: 347-351.
Hard ML, Einarson TR, Koren G: The role of acetaldehyde in
pregnancy outcome after prenatal alcohol exposure. Therapeutic
Drug Monitoring: 2001: 23: 427-434.
Hard ML, Raha S, Spino M, Robinson BH, Koren G: Impairment of
pyruvate dehydrogenase activity by acetaldehyde. Alcohol: 2001:
25: 1-8.
Ho E, Collantes A, Kapur BM, Moretti ME, Koren G: Alcohol and
breastfeeding; calculation of time to zero level in milk. Biol Neonate:
2001: 80: 219-222.
Ho E, Tabesh L, Koren G: Characteristics of pregnant women who use
Ecstasy. Neurotoxicology and Teratology: 2001: 23: 561-567.
Ito S: Transplacental treatment of fetal tachycardia: implications of drug
transporting proteins in placenta. Sem Perinatol 2001: 25: 196-201
15

Jasper JD, Goel R, Einarson A, Gallo M,
Koren G: Effects of framing on
teratogenic risk perception in pregnant
women. Lancet: 2001: 358: 1237-1238.
Kapur B, Hackman R, Selby P, Klein J,
Koren G: Randomized, double blind
placebo controlled trial of nicotine
replacement therapy in pregnancy.
Current Ther Resp: 2001: 62: 274-280.
Kapur B, Koren G: Motherisk alert: Folic
acid fortification of flour - three years
later. Canadian Journal of Clinical
Pharmacology: 2001: 8: 91-92.
Klinger G, Morad Y, Westall CA, Laskin C,
Spitzer KA, Koren G, Ito S, Buncic RJ:
Antenatal exposure to chloroquine or
hydroxycloroquine for rheumatic diseases
- Is there evidence of ocular toxicity?
Lancet: 2001: 358: 813-814.
Kopecky EA, Jacobson S, Bch MB, Hubley P,
Palozzi L, Clarke HM, Koren G: Safety
and pharmacokinetics of EMLA in the
treatment of postburn pruritus pediatric
patients: a pilot study. Journal of Burn
Care and Rehabilitation: 2001: 22: 235-242.
Koren G: Drinking alcohol while breastfeeding.
Will it harm my baby? Canadian Family
Physician: 2001: 48: 39-41.
Koren G: Glyberide and fetal safety;
Transplacental pharmacokinetic
considerations. Reproductive Toxicology:
2001: 15: 227-229.
Koren G: Is there a risk of antidepressants
in pregnancy? Canadian Family
Physician: 2001.
Koren G: Maternal obesity and risk of
neural tube defects. Canadian Family
Physician: 2001: 47: 1385-1387.
Koren G: Nicotine replacement therapy
during pregnancy. Canadian Family
Physician: 2001: 47: 1-2.
Koren G: SSRI's in pregnancy. Are they safe?
Pediatric Research: 2001: 51: 424-425.
Koren G, Chan D, Klein J, Karaskov T:
Estimation of fetal exposure to drugs of
abuse, environmental tobacco smoke,
and ethanol. Therapeutic Drug
Monitoring: 2001: 24: 23-25.
Koren G, Cohn T, Chitayat D, Kapur B,
Remington G, Reid DM, Zipursksy RB:
Use of atypical antipsychotics during
pregnancy and the risk of neural tube
defects in infants. American Journal of
Psychiatry: 2001: 159: 136-137.
Koren G, Money D, Boucher M, Aoki F,
Petric M, Innocencion G, Wolosk M,
Remple V, Pelland F, Geist R, Ho T, Bar-Oz
B, Loebstein R: Serum concentrations,
efficacy, and safety of a new
intravenously administered varicella
zoster immune globulin in pregnant
women. Journal of Clinical
Pharmacology: 2001: 42: 267-274.
16
Koren G, Schuler L: Taking drugs during
pregnancy. How safe are the unsafe.
Canadian Family Physician: 2001: 47:
951-953.
Koren G: The use of glyberide ingestational
diabetes-an ideal example of “bench to
bedside”. Pediatric Research: 2001: 49: 734.
Kozer E, Koren G: Effects of prenatal
exposure to marijuana. Canadian Family
Physician: 2001: 47: 263-264.
Kozer E, Koren G: Management of
paracetamol overdose: current controversies.
Drug Safety: 2001: 24: 503-512.
Kozer E, Moretti ME, Koren G:
Leflunomide: new anti-rheumatic drug.
Effect on pregnancy outcomes. Canadian
Family Physician: 2001: 47: 721-722.
Kramer MS, Goulet L, Lydon J, Seguin L,
McNamara H, Dassa C, Platt RW, Chen
MF, Gauthier H, Genest J, Kahn S,
Libman M, Rozen R, Masse A, Milner L,
Asselin G, Benjamin A, Klein J, Koren G:
Socio-economic disaparities in preterm
birth: causal pathways and mechanisms.
Paediatric Perinatal Epidemiology: 2001:
15: 104-123.
Levichek Z, Atanackovic G, Oepkes D,
Maltepe C, Einarson A, Magee L, Koren
G: Nausea and vomiting of pregnancy.
Evidence based treatment algorithm.
Canadian Family Physician: 2001: 48:
267-8,277.
Lobuagh NJ, Karaskov V, Rombough V,
Rovet J, Bryson S, Greenbaum R, Haslam
RH, Koren G: Piracetam therapy does not
enhance cognitive functioning in
children with down's syndrome. Archives
of Pediatrics and Adolescent Medicine:
2001: 155: 442-448.
Loebstein R, Koren G: Clinical relevance of
therapeutic drug monitoring during
pregnancy. Therapeutic Drug Monitoring:
2001: 24: 15-22.
Lyszkiewicz DA, Gerichhausen S,
Bjornsdottir I, Einarson TR, Koren
G,Einarson A: Evidence based information
on drug use during pregnancy: a survey
of community pharmacists in three
countries. Pharmacology World Science:
2001: 23: 76-81.
Magee LA, Bull SB, Koren G, Logan A: The
generalizability of trial data: A
comparison of beta-blocker trial
participants with a prospective cohort of
women taking beta-blockers in
pregnancy. European Journal of
Obstetrics Gynecological Reproductive
Biology: 2001: 94: 205-210.
Mazzota P, Stewart DE, Koren G, Magee LA:
Factors associated with elective
termination of pregnancy among
Canadian and American women with
nausea and vomiting of pregnancy.
Journal of Psychosomatic Obstetrical
Gynaecology: 2001: 22: 7-12.
McMartin KI, Klein J, Hackman R, Platt MS,
Koren G: Measurements of lung tissue
concentrations of nicotine and cotinine
in SIDS. Journal of Pediatrics: 2001: 140:
205-209.
Mungan N, Wilson TW, Nischalk K,
Khattak S, Ho T, Koren G, Levin A: Lifethreatening
complications of Alphagan in
infants. American Journal of
Ophthalmology: 2001.
Nevin AC, Parshuram C, Nulman I, Koren
G, Einarson A: A survey of physicians
knowledge regarding awareness of
maternal alcohol use and the diagnosis of
FAS. BMC Family Practice: 2001: 3: 2.
Nikfar S, Koren G: Managing
heypthyroidism during pregnancy.
Canadian Family Physician: 2001: 47:
1555-1556.
Nulman I, Laslo D, Fried S, Uleryk E,
Lishner M, Koren G: Neurodevelopment
of children exposed in utero to treatment
of maternal malignancy. British Journal
of Cancer: 2001: 85: 1611-1618.
Nulman I, Rovet J, Greenbaum R, Loebstein
M, Wolpin J, Pace-Asciak P, Koren G:
Neurodevelopment of adopted children
exposed in utero to cocaine. The Toronto
adoption study. Clinical and Investigative
Medicine: 2001: 24: 129-137.
Nulman I, Wolpin J, Thies I, Stewart D,
Koren G: Perinatal gestational exposure
to antidepressants; separating the effects
of depression, pharmacotherapy and
other confounders. American Journal of
Psychiatry: 2001.
Pole M, Koren G: Finasteride. Does it affect
spermatogenesis and pregnancy?
Canadian Family Physician: 2001: 47:
2469-2470.
Roberts W, Weaver L, Brian J, Bryson S,
Emelianova S, Griffiths AM, MacKinnon
B, Yim C, Wolpin J, Koren G: Repeated
doses of porcine secretin in the treatment
of autism: a randomized, placebocontrolled
trial. Pediatrics: 2001: 107: E71.
Scmid R, Koren G, Klein J, Katz J: The
stability of a ketamine-morphine solution.
Anesth Analog: 2001: 94: 898-900.
Selby P, Hackman R, Kapur B, Klein J,
Koren G: Heavily smoking women who
cannot quit in pregnancy: Evidence of
pharmacokinetic predisposition.
Therapeutic Drug Monitoring: 2001: 23:
189-191.
Sgro MD, Barozzino T, Mirghanai HM,
Sermer M, Moscato L, Akoury H, Koren
G, Chitayat D: Pregnancy outcome post
renal transplantation. Teratology: 2001:
65: 5-9.

Stempak D, Dallas S, Klein J, Bendayan R,
Koren G, Baruchel S: Glutathione stability
in whole blood: Effects of various
deproteinizing acids. Therapeutic Drug
Monitoring: 2001: 23: 542-549.
Taddio A, Gurguis MG, Koren G: Lidocaine-
Prilocaine cream versus tetracaine gel for
procedural pain in children. Annals of
Pharmacotherapy: 2001: 36: 687-692.
Till C, Koren G, Rovet JF: Prenatal exposure
to organic solvents and child
neurobehavioral performance.
Neurotoxicology Teratology: 2001: 23:
235-245.
Till C, Westall CA, Rovet JF, Koren G:
Effects of maternal occupational exposure
to organic solvents on offspring visual
functioning: A prospective controlled
study. Teratology: 2001: 64: 134-141.
Ursitti F, Klein J, Koren G: Confirmation of
cocaine use during pregnancy: a critical
review. Therapeutic Drug Monitoring:
2001: 23: 347-353.
Ursitti F, Klein J, Sellers E, Koren G: Use of
hair analysis for confirmation of selfreported
cocaine use in users with
negative urine tests. Journal of
Toxicology, Clinical Toxicology: 2001: 39:
361-366.
Vohra S, Koren G: Hypothetical framework
for a relationship between maternal
thyroid function nausea and vomiting of
pregnancy, and congenital heart disease.
Medical Hypotheses: 2001: 56: 392-394.
Wong M, Koren G: Bias in maternal reports
of smoking during pregnancy associated
with fetal distress. Canadian Journal of
Public Health: 2001: 92: 109-112.
books and book chapters
Taddio A, Ito S: Drug use during lactation-a
review. In: G. Koren, ed. Maternal Fetal
Toxicology: a clinician’s guide. Marcel
Dekker, NY, 3rd ed. p177-232, 2001
Ito S: Drug use during pregnancy and
lactation. In: Pediatric drug therapy
handbook. I. Yoshida ed. Chuugai
Publishing (Tokyo). First ed. 2001: 32-36
Ito S, A Massicotte. Compendium of
Pharmaceuticals and Specialties, 36th ed.
2001: L41-L43 (Drug Exposure during
Pregnancy)
Ito S, D Matsui. Compendium of
Pharmaceuticals and Specialties, 36th ed.
2001: L44-L46 (Drug Exposure during
lactation)
Koren G: Special aspects of perinatal and
pediatric pharmacology. In: Katzung BG,
ed: Basic & Clinical Pharmacology. Lange
Medical Books/McGraw-Hill. 8th Edition,
2001, NY.
Shilalukey K, Koren G: Special
considerations in pregnant women. In:
Clinical Toxicology, (Ford, Delaney, Ling,
Erikson, ed) pp. 101-110, 2001. WB
Saunders. Philadlphia.
Koren G: Maternal-Fetal Toxicology; A
Clinician’s Guide. Third Edition, Marcel
Dekker, new York, 2001.
research and investigations
Antioxidants in Fetal Alcohol
Syndrome. Brien J, Koren G, Rovet J and
Other: New Emerging Team Grant, CIHR
($1,250,000 2002 - 2007)
Breaking the Cycle Program.
Koren G: Health Canada ($3,740,000
1994 - 2005).
Depression during breastfeeding:
the health of the mother and
infant. Ito S: Physicians Services
Incorporated ($123,600 2002 - 2004).
Determinants of renal handling of
drugs during development. Koren G:
CIHR Grant MA 8544 ($1,600,000 1984 -
2004).
Determinants of women's decisionmaking
of antidepressants during
pregnancy. Koren G: Ontario Women's
Health Council ($138,900 2001 - 2003).
Errors in drug dosing in children.
Parshuram C, Koren G, Bohn D: Critical Care
Foundation ($50,000 2002 - 2003).
Evaluating safety and risk of
antiretroviral drug exposure
during pregnancy for infants born
to HIV positive women in Ontario.
King SM, Koren G: Ontario HIV Treatment
Network (NHTV) ($175,000 1999 -
2002).
Maternal occupational exposure
to organic solvents during
pregnancy and infant visual
processing. Koren G, Rovet J, Estall C:
Workplace Safety and Insurance Board's
Research Advisory Council ($252,000
2001 - 2004).
Mechanisms of drug transfer into
human milk [MT-13747: Renewed
in 1999]. Ito S: CIHR ($219,852 1999 -
2002).
Organic cation uptake in the
human mammary gland:- Validity
of MCF12A cell model. Ito S (Principle
investigator): Food and Drug
Administration (USA) ($37,500 2001-
2002)
Propylthiouracil use during
breastfeeding: The cost of
misinformation. Ito S (Principle
investigator): Canadian Foundation for
Women’s Health (The Duchensney Fund
for better use of drugs during
pregnancy and lactation) ($16,000
2002-2003)
The role of the placenta in the
fetal toxicology [MT-1797:
Renewed in 1999]. Koren G, Derewlany
L, Ito S (Co-Investigators): CIHR ($252,720
1999 - 2002).
The safety of ondansetron in
pregnancy. Koren G, Einarson A: Glaxo
SKB ($60,000 2001 - 2002).
The teratogenicity of aspirin in
humans. Meta analysis. Koren, G:
Pfizer ($120,000 2001 - 2002).
Treatment of morning sickness.
Koren G: Duchesnay, Laval Quebec
($240,000 1994 - 2002).
Use of biotechnological products
during pregnancy and lactation.
Koren G: Health Canada ($56,000 2001 -
2002).
17

faculty William Mounstephen – head, Kathy Boutis, Carolyn Calpin, Anh Do,
Cara Gilman, Leah Harrington, Anna Jarvis, Kelly Keogh, Tanuja Kodeeswaran,
Luba Komar, Andrew Mason, Bruce Minnes, Trent Mizzi, Jonathan Pirie,
Jennifer Riley, Maryanne Robb, Susan Schneeweiss, Suzanne Schuh, Dennis
Scolnik part-time Sherry Baine, Stephen Baker, Alan Berzen, Susanna
Benseler, Mijin Brown, Umberto Cellupica, Gail Churchill, Dave Clarke, Carlos
Contreras, Sheila David, Paul Dick, Martha Dirks, Katy Driver, Carol Durno,
Janine Flanagan, John Freedman, Claudio Fregonas, Michael Fox, Beth
Gamulka, Sabine George, Peter Glazer, Donna Goldenberg, Shawna
Granovsky, Massoud Grouhi, Astrid Guttmann, Suja Hafiz, Mark Handley-
Derry, Eleonora Hansch, Jim Hilton, Annie Huang, Anthony Hui, Nicole Inch,
Jaya Islur, Andrew James, Fatima Kamalia, Shahida Khan, Sohail Khattak,
Eddy Lau, Yen Le, Peter Lewin, Patricia Linders, Karen Mandel, John Mendes,
Annette Miller, Diana Mills-Tettey, Steven Moss, Paul Nathan, Patricia
Neelands, Eric Nisbet-Brown, Carole O’Beirne, Evangelina Papdouris, Jocelyn
Parent, Linda Pedder, Pratap Rastogi, Lillian Rojnica, Antonina Saksznajder,
Domenick Shelton, Raymond Shu, Janet Star, Heshy Sturm, Catherine Taylor,
Jonathan Tolkin, Sunita Vohra, Jeffrey Weisbrot, Hilary Whyte, Sheldon Wise,
Hirotaka Yamashiro, Albert Yeung, Conrad Yim Clinical Fellows Fahad Al-
Mukhaizeem, Jane Edwards, Ran Goldman, Eran Kozer, Benjamin Stanhope
Research Fellows Amina Lalani, Ahmed Mater, Sanjay Mehta
The Emergency Department at the Hospital for Sick
Children provides acute care to children who are ill or
who have been injured. We are both the primary care
centre for children in Toronto, plus the tertiary referral
centre for the GTA, in addition to being the designated
Paediatric Trauma Centre for the GTA. Over the last
year, we have worked with EMS, CCU, and NICU to
begin the development of a paediatric transport system
for the GTA, which is a vital component to the
provision of care to acutely ill or injured children.
The Division has an active 3 year Academic Fellowship
program. The Royal College of Physicians and Surgeons
has recently accredited our fellowship program. In
addition, we have a number of clinical departmental
fellows from around the world spending a year with us,
further developing their paediatric emergency medicine
skills. The division has run approximately 12 Paediatric
Life Support Courses (PALS or APLS) over the last year.
We also have a well developed half-day for educational
activities for trainees and all Health care providers in
the Emergency Department.
Research in the Division remains clinically focused,
covering a wide range of topics from respiratory disease
acute care management, orthopaedic ankle injuries,
pain and sedation, to drug errors. Two additional
18
Division of EMERGENCY
clinician investigators have joined the division, Dr.
Kathy Boutis and Dr. Dennis Scolnik. An increase in
clinical research activities has resulted. Research done
within the division continues to be presented nationally
and internationally, with publication in peer reviewed
journals.
publications
Boutis K, Komar L, Jaramillo D, Babyn P, Alman B, Snyder B, Mandl
KD, Schuh S: Sensitivity of a clinical examination to predict need for
radiography in children with ankle injuries: a prospective study. The
Lancet: 2001: 358: 2118-2121.
Ford Jones EL, Komar L: Statement of National Advisory Committee
on Recommended Use of Meningococcal Vaccine. The Pediatric
Infection Report: 2002: 6: 2-3.
Freedman S, Marrocco A, Pirie J, Dick P: Predictors of bacterial
meningitis in the era after Haemophilus influenzae. Archives of
Pediatric Adolescent Medicine: 2001: 155: 1301-1306.
Keogh KA, Parkin PC, Macarthur C, Stephens D, Arseneault R, Tennis
O, Bacal L, Schuh S: Predictors of hospitalization in children with
acute asthma. The Journal of Pediatrics: 2001: 139: 273-277.
Petric M, Komar L: Myositis during recovery from influenza. The
Pediatric Infection Report: 2002: 6:4.
Schuh S, Coates AL, Binnie R, Allin T, Goia C, Corey M, Dick PT:
Efficacy of oral dexamethasone in outpatients with acute
bronchiolitis. Journal of Pediatrics: 2002: 140: 27-32.
Yaffe B, Komar L: Red Measles (Rubeola) Diagnosis. Pediatric Infection
Report: 2001: 5-9: 3.
books & books chapters
Jarvis A et al: Drug Therapy for Emergency Physicans. (Lexchin, J,
eds). Canadian Association of Emergency Physicians: 2002.
Jarvis A: Drowning, Electrical Injuries. In: Oxford Textbook of Primary
Care. 2002.
Jarvis A, LeBlanc L, Warren D: Canadian Paediatric Triage and Acuity
Scale: Implementation Guidelines for Emergency Departments.
Canadian Journal of Emergency Medicine (CJEM) (Endorsed by the
Canadian Association of Emergency Physicians, the Canadian
Paediatric Society, the National Emergency Nurses Affilitation, and
l'Association des medecins d'urgence du Quebec (AMUQ), eds).
Canadian Association of Emergency Physicians, Ottawa, ON: 2001.
Research and investigations
Care of children with Asthma discharged from the ED:
Is an asthma home care program beneficial? Cicutto L,
Spalding K, Mounstephen W: HSC Foundation ($125,000 1999 - 2002).
Do children with acute bronchiolitis need chest
radiographs? Dick PT, Schuh S (Co-Principal Investigators), Manson D,
Babyn P, Lalani A, Stephens D: PSI ($108,000 2001 - 2004).
Efficacy of humidity in children with acute croup. Scolnik
D, Schuh S (Co-Primary Investigators), Stephens D, Lavine E, Coates A,: PSI
($170,000 2001 - 2003).

Efficacy of inhaled fluticasone
propionate versus oral prednisolone
in outpatients with mild to
moderate acute asthma. Schuh S,
Reisman J, Alshehri M, Dupuis A, Corey M,
Arseneault R, Alothman G, Tennis O, Canny G:
Glaxo Smith Kline ($220,000 2001 - 2003).
Efficacy of oral dexamethasone in
the emergency therapy of acute
bronchiolitis. Schuh S, Coates A, Binnie R,
Allin T, Goia C, Corey M, Dick PT: Medical
Research Council - PMAC Grant
($21,485 1998 - 2001).
Indications for CAT Scan Head
Studies in children who have
experienced minor head injuries.
Paediatric Emergency Research Committee -
Klassen T, Jarvis DA (CPA): Paediatric Emergency
Research Committee. A collaborative trans-
Canada study - 1997 - present ($12,024
1997 - 2002).
Interleukin 6 levels in febrile
children with bacteremia.
Kodeeswaran T, Allen U, Samson L, Shemie S,
Schuh S: PSI Grant ($15,000 1998 -
2001).
Reducing prescription errors in a
pediatric emergency department -
a randomized controlled trial.
Kozer E, Scolnik D: Trainee's Start-up Fund
($2,000 2001 - 2002).
Telephone Triage Concordance
Study. McGuigan M, Wood C, Gaudet J,
Mounstephen W: iMcKesson ($675,000
2000 - 2001).
Tetracaine (AMETOP) versus EMLA
for intravenous cannulation of
children in the emergency
department - a randomized,
double blind trial. Scolnik D,
Rauchwerger D, Abdolell M, Schuh S: Smith &
Nephew Inc. ($5,000 2002).
The Pediatric Acute Asthma
Management Protocol (PAMP)
Project - development,
implementation and outcomes
project. To T, Dell S, Fleming-Carroll B,
MacLusky I, Parkin P, Scolnik D, Ungar W:
GlaxoSmithKline, Merck, Byk ($210,000
2002 - 2004).
Validation of temporal arterial
heat thermometry by its comparison
with esophageal temperature in
children. Al-Mukhaizeem F, Schuh S (Co-
Senior Investigators), Roy L, Naser B, Komar L,
Stephens D, Allen U: Exergen-Phillips Grant
($42,000 2001 - 2002).
19

faculty Denis Daneman – Chief, Kusiel Perlman, Jill Hamilton, Amira Klip,
Joanne Rovet, Etienne Sochett, Diane Wherrett part-time Susan Kirsch, Section
of Gynaecology – Victoria Davis – Head, Lisa Allen, Nicolette Caccia, Melanie
Ornstein, Nancy Van Eyk, Georgina Wilcock, Brenda Woods clinical fellows
Gherta Brill research fellows Jacqueline Curtis, Carol Huang, Daniel Konrad,
Outi Makitie residents Fayza Al-Jenaidi, Robert Stein, Stacey Urbach
2001-2002 was an extremely active and productive year
for the Endocrine Division. The major accomplishments
include: (i) completion of the ambulatory Centre for
Endocrinology and Diabetes incorporating the Endocrine
Testing as well as Diabetes Day Care facilities; (ii) further
development of specialty clinics, including Intersex,
Calcium and Osteoporosis and the Girls and Young
Women’s Reproductive Health Clinic. These multidisciplinary
clinics bring together endocrinology and other health
professionals integral to the complex medical and
surgical needs of these patients; (iii) enhancement of
the Diabetes Team include an increased pump program,
outreach and educational opportunities; (iv) successful
competition for research funding and ongoing studies in
the areas of diabetes prevention, eating disorders in girls
with type 1 diabetes, mechanisms of early diabetic
nephropathy, cell biology of glucose uptake and insulin
signalling, neurocognitive outcomes in congenital
hypothyroidism. The number and excellence of
residents and fellows entering the program from many
parts of the world highlight the success of the Pediatric
Endocrinology Training Program.
publications
Bohn D, Daneman D. Diabetic ketoacidosis and cerebral edema.
Current Opinion in Pediatrics 14: 287-291, 2002.
Curtis J, Bohn D, Daneman D. Hypertonic saline in the treatment of
cerebral edema associated with diabetic ketoacidosis. Pediatric
Diabetes 2:191-194, 2001.
Curtis J, To T, Cummings E, Muirhead S, Daneman D. Recent Trends
in Hospitalization for Diabetic Ketoacidosis (DKA) in Ontario
Children. Diabetes Care 25: 1591-1596, 2002.
Daneman D. Islet cell transplantation and other new technologies for
treating type 1 diabetes: A pediatric view. Horm Res 57 Suppl 1:54-9,
2002.
Daneman D, Rodin G, Jones J, Colton P, Rydall A, Maharaj S,
Olmstead M. eating disorders in girls with type 1 diabetes. Diabetes
Spectrum (monograph) 15(2):83-105, 2002.
Daneman D. Between the devil and the deep blue sea! (Editorial)
Canadian J Diabetes Care 26:97-98, 2002.
Danne T, Mortensen HB, Hougaard P, Lynggaard H, Aanstoot H-J,
Chiarelli F, Daneman D, et al: Persistent center differences over 3
years in glycemic control and hypoglycemia in a study of 3,805
children and adolescents with type 1 diabetes from the Hvidore
Study Group. Diabetes Care: 2001: 24: 1342-1347.
Davis VJ, Mykitiuk R: The rights of the adolescent – the mature minor.
(reprinted) Canadian Association for Adolescent Health: 2001: 10: 32.
20
Division of ENDOCRINOLOGY
DCCT Research Group: Influence of intensive diabetes treatment on
body weight and composition of adults with Type 1 diabetes in the
Diabetes Control and Complications Trial. Diabetes Care: 2001: 24:
1711-1721.
Diabetes Prevention Trial Type-1 Study Group. Results of trial of
prevention of type 1 diabetes in high-risk relatives. NEJM 346: 1685-
1691, 2002.
Foster, L. J., Li, D., Randhawa, V., Klip, A. (2001) Insulin accelerates
inter-endosomal GLUT4 traffic via phosphatidylinositol 3-kinase and
protein kinase B. J. Biol. Chem. 276: 44212-44221.
Hamilton J, Daneman D: Deteriorating diabetes control during
adolescence: Physiological or psychosocial. Journal of Pediatric
Endocrinology and Metabolism: 2002: 15: 115-126.
Hepworth S, Rovet J. (2001)Visuospatial integration difficulties in a
female with Turner Syndrome. Impact on Verbal abilities. Child
Neuropsychology, 6:262-273.
Hoey H, Aanstot H-J, Chiarelli F, Daneman D, et al. Good metabolic
control is associated with better quality of life in type 1 diabetes.
Hvidore study on 2101 children and adolescents. Diabetes Care
24(11):1923-1928; 2001
Holcombe John H, Zalani S, Arora Vipin K, Mast Casey J. for the
Lispro in Adolescents Study Group (includes Perlman K.):
Comparison of insulin Lispro with regular human insulin for the
treatment of Type 1 Diabetes in adolescents. Clinical Therapeutics:
2002: 24 : 629-638.
Maharaj S, Rodin G, Connolly, J, Olmsted M, Daneman D. Eating
problems and the observed quality of mother-daughter interactions
among girls with type 1 diabetes. J Consult Clin Psychol 69:950-8,
2001.
Nulman I, Rovet J, Greenbaum R, Loebstein M, Wolpin J, Pace-Asciak
P, Koren G. (2001) Neurodevelopment of adopted children exposed
in utero to cocaine: the Toronto Adoption Study. Clinical and
Investigative Medicine, 34:129-137.
Olmsted M, Daneman D, Rydall A, Lawson M, Rodin G. The effects of
psychoeducation on disturbed eating attitudes and behavior in
young women with type 1 diabetes. International Journal of Eating
Disorders 32:230-239, 2002
Rovet J, Hepworth S. (2001) Attention problems in adolescents with
congenital hypothyroidism: A multicomponential analysis. Journal
of the International Neuropsychological Society, 7, 734-744.
Rovet J, Hepworth S. Dissociating attention deficits in children with
ADHD and congenital hypothyroidism using multiple CPTs. Journal
of Child Psychology & Psychiatry, 42:1049-1056, 2001
Somwar, R., Kim, D. Y., Sweeney, G., Niu, W., Lador, C., Ramlal, T. and
Klip, A. (2001) GLUT4 translocation precedes the stimulation of
glucose uptake in muscle cells: potential activation of GLUT4 via
p38 MAPK. Biochem J. 359: 639-649.
Somwar, R., Niu, W., Kim, D. Y., Sweeney, G., Randhawa, V. K., Huang,
C., Ramlal, T. and Klip, A. (2001) Differential effects of
phosphatidylinositol 3-kinase inhibition on intracellular signals
regulating GLUT4 translocation and glucose transport. J. Biol. Chem
276: 46079-46087
Song S-I, Daneman D, Rovet J: The influence of etiology and
treatment factors on intellectual outcome in congenital
hypothyroidism. Journal of Developmental and Behavioural
Pediatrics: 2001: 22: 376-384.
Sweeney, G., Niu, W., Canfield, V. A., Levenson, R. and Klip, A. (2001)
Insulin increases the plasma membrane content and reduces the
phosphorylation of Na,K-pump a1 subunit in human embryonic
kidney cells. Am. J. Physiol. (Cell Physiol.) 281: C1797--C1803.
Sweeney, G., Keen, J., Somwar, R., Konrad, D. and Klip, A. (2001) High
leptin levels acutely inhibit insulin-stimulated glucose uptake
without affecting GLUT4 translocation in L6 rat skeletal muscle
cells. Endocrinology 142: 4806-4812.

Till C, Koren, G, J, Westall C, Rovet, J (2001).
Prenatal exposure to organic solvents and
child neurobehavioral performance.
Neurotoxicology and Teratology, 23, 235-
245.
Till C, Westall C, Rovet JF, Koren G. (2001).
Prenatal exposure to organic solvents and
color vision impairment. Teratology
64:134-141.
books and book chapters
Curtis J, Hamilton J, Beck C, Frank M,
Daneman D. Pediatric Diabetes. In: Evidence-
Based Diabetes Care, eds. Gerstein H, Haynes
B. BC Decker 2001, pages 107-123.
Daneman D, Frank M, Perlman K. When a
Child has Diabetes. Key Porter Books,
Toronto 2002 (2nd Edition).
Koren, G., Nulman, I., Rovet, J., Greenbaum,
R., Loebstein, M., Einarson, T.R. (2001) Longterm
neurodevelopmental risks in children
exposed in utero to cocoain. In. G. Koren
(Ed). Maternal-Fetal Toxicology, Third Edition.
New York: Marcel Dekker, pp. 447-456.
Rovet J (2002). Long term follow-up of
children born with sporadic congenital
hypothyroidism. A Deacde of Advances in
Thyroidology, 66-70.
Till, C, Rovet, J. F., Koren, G, Westall, C. A.
Assessment of visual functions following
prenatal exposure to organic solvents.
National Institute for Occupational Safety
and Prevention (ISPESL). 2002
research and investigations
A 24-week randomized, doubleblind,
active-controlled multicentre
study to evaluate the safety
and efficacy of rosiglitazone when
administered to pediatric patients
with type 2 diabetes mellitus.
Hamilton J: GlaxoSmithKline ($20,000 2001
- 2002).
A comparison of two family-based
interventions for girls with type 1
diabetes and problematic eating
attitudes and behaviours. Daneman D:
Canadian Diabetes Association ($75,000
2001 - 2003).
Efficacy and safety of somatropin
treatment in paediatric patients
with SHOX-Disorder and SHOX-
Deficient Turner Syndrome. Wherrett
DK: Eli Lilly Canada Inc. ($41,420 2001 -
2002).
Fetal Alcohol Syndrome: Oxidative
Stress and Innovative Therapies. Brien,
J, Rovet J: Canadian Institutes of Health
Research New Emerging Team Grant
($1,250,000 2002 – 2007)
Genentech National Cooperative
Growth Study (NCGS) post marketing
surveillance program for protropin
and nutropin. Hamilton J: Hospital for Sick
Children ($7,500 2001 - 2002).
GLUT4 activation in insulin action
and insulin resistance. Klip A: Canadian
Diabetes Association Grant-In-Aid
($150,000 2002-2004)
GLUT4 transgenic mice: a tool for
the development of unique antidiabetic
drug Strategies. Klip A.
Canadian Institutes for Health Research
Proof-of-Principle Grant ($93,000 2002-
2003)
Hormonal regulation of p38 MAPK
and its implications for glucose
transport. Klip A: Canadian Institutes of
Health Research Operating Grant
($663,610 2002-2007)
Hypoglycemia and brain function in
children with diabetes. Rovet J. -
Psychology Research, Hospital for Sick Children,
Co Investigator Perlman K: Banting and Best
Diabetes Centre ($19,500 2000 - 2001).
Hypothyroxinemia of Prematurity.
Rovet, J: March of Dimes ($129,150 (USD)
2001- 2004)
Is poor glycemic control in
adolescents with type 1 diabetes
amenable to pharmacotherapy? A
pilot study of the insulinsensitizing
agent, metformin.
Daneman D, Hamilton J, Cummings B, Sochett E:
Hospital for Sick Children - Research
Institute Seed Grant ($29,820 1998 -
2001).
Maternal occupational exposure to
organic solvents during pregnancy
and infant visual processing. Rovet J:
Workman’s Safety Insurance Board
($258,000 2001- 2003)
Psychosocial adjustment and
gender identity in genetic males
born with ambiguous genitalia.
Wherrett DK, Zucker K, Neilson B, Bradley S: The
Hospital for Sick Children, Research
Institute ($31,180 2001 - 2003).
School attendance in children with
type 1 diabetes. Daneman D: Eli Lilly
Canada (unrestricted grant) ($26,000
2001).
Spatial-temporal resolution of the
intracellular traffic of glucose
Transporter. Klip A: Canadian Institutes
for Health Research, Operating Grant
($663,610 2000-2005)
The Canadian/European trial of
nicotinamide to prevent insulin
dependent diabetes mellitus.
Wherrett D: Medical Research Council of
Canada ($36,000 1998 - 2002).
The genetics and
neuroendocrinology of short
stature. Hamilton J: Lilly International
Growth Study (GeNeSIS) ($50,000 2001 -
2002).
Thyroid hormone and infant visual
development. Rovet J: Canadian
Institutes of Health Research ($328,000
2001 – 2005)
TrialNet - Preservation of beta cells
by glutamate decarboxylase. Wherrett
DK, Mahon J, Daneman D: National Institute
of Health ($1,187,072 2001 - 2008).
Type 1 Diabetes TrialNet - The
Impact of GAD on Preservation of β
Cell Function. Wherrett DK, Mahon J,
Daneman D: National Institutes of Health
($1,960,000 2001-2008)
21

full time Stanley Zlotkin, Mary Corey, Peter Durie, Katryn Furuya, Nicola
Jones, Anne Griffiths, Margaret Marcon, Vicky Ng, Paul Pencharz, Eve Roberts,
Philip Sherman, Mary Zachos part time Glenn Berall, Carol Durno clinical
fellows Najma Ahmed, David Mitchell, Elyanne Ratcliffe, Susanne Schibli,
research fellows Jeff Critch, Martha Dirks, Hien Huynh, Reuben Jackson,
Sylvie Lebel, Latifa Yeung
The Division of GI/Nutrition has a fully integrated
program in paediatric clinical nutrition, luminal
gastroenterology, hepatology and transplantation
making it one of few in North America with total
paediatric ‘GI-coverage’.
The Division continues its proud heritage as the preeminent
Canadian academic GI/Nutrition Fellowship
Program. The program offers one year of clinical
training and two research years. The clinical component
includes a wide array of experiences including
procedures (endoscopy, manometry, liver biopsies and
calorimetry); in-patient management (transplant, GI
and nutrition), ambulatory clinics (including
hepatology, home-TPN, dysphasia, general GI,
hepatology and nutrition), evidence-based rounds and
training in ethics and communication. Many of our
trainees in the research program (two years) combine a
formal degree-granting program (MSc or PhD) with their
research fellowship years.
The Division hosts eleven full-time staff, two part-time
and two-cross-appointed members. Our research spans
the spectrum from basic and translational to patientbased
in such areas as cystic fibrosis, inflammatory
bowel diseases, nutrition and hepatology. Funding
support (over two million dollars annually) includes
grants from the CIHR, NIH, CF Foundation, Crohn’s and
Colitis Foundation, the HJ Heinz Co. Foundation,
Canadian Digestive Disease Foundation, the CDC,
Health Canada and more.
publications
Bourke B, Jones NL: Pathogenesis of Helicobacter pylori infection.
Current Opinions in Gastroenterology: July 2001: 17: 24-29.
Buchholz A, Rafii M, Pencharz PB: Resting metabolic rate adjusted for
lean body mass does not differ between adult men and women.
British Journal of Nutrition: 2001: 86: 641-646.
Corey, M: Modelling Survival in cystic fibrosis (editorial). Thorax:
2001: 56: 743.
Day A, Jones N, Policova Z, Jennings H, Yau E, Shannon P, Neumann
A, Sherman P: Characterization of virulence factors of mouseadapted
Helicobacter pylori strain SS-1 and effects on gastric
hydrophobicity. Digestive Diseases and Sciences: 2001: 46: 1943-1951.
22
Division of GI/NUTRITION
Di Buono M, Wykes LJ, Ball RO, Pencharz PB: Total sulphur amino
acid requirements in young men determined by indicator amino
acid oxidation with L- {1-13C} phenylalanine. The American Journal
of Clinical Nutrition: 2001: 74: 756-760.
DiBuono M, Wykes LJ, Ball RO, Pencharz PB: Dietary cysteine (CYS)
reduces methionine (MET) requirement in adult males. American
Journal of Clinical Nutrition: 2001: 74: 761-766.
Fitzpatrick K, Sherman P, Ipp M, Saunders N, Macarthur C: Screening
for celiac disease in children with recurrent abdominal pain. Journal
of Pediatric Gastroenterology and Nutrition: 2001: 33: 250-252.
Gold B, vanDoorn L, Guarnre J, Owens M, Pierce-Smith D, Song Q,
Hutwanger L, Sherman P, deMola O, Czinn S: Genotypic, clinical
and demographic characteristics of children infected with
Helicobacter pylori . Journal of Clinical Microbiology: 2001: 39:
1348-1352.
Griffiths AM, Zachos M: Antineutrophil Cytoplasmic Antibodies and
Anti-Saccharomyces cerevisiae antibody: Clinical tools or clues for
research. Journal of Pediatric Gastroenterology and Nutrition: 2001:
30: 1-2.
Hoglund P, Holmberg C, Sherman P, Kere J: Distinct outcomes of
chloride diarrhea in two siblings with identical genetic background
of the disease: Implications for early diagnosis and treatment. GUT:
2001: 48: 724-727.
Hunt R, Fallone C, Van Zanten, Sherman P, Smaill F, Thomson A: Risks
and benefits of Helicobacter pylori eradication: Current status.
Canadian Journal of Gastroenterology: 2002: 16: 57-62.
Jin S, Joe A, Lynett J, Hani E, Sherman P, Chan V: JlpA, a novel
surface-exposed lipoprotein specific to Campylobacter jejuni.
Molecular Microbiology: 2001: 39: 1225-1236.
Johnson-Henry K, Wallace J, Basappa N, Soni R, Wu G, Sherman P:
Inhibition of attaching-effacing lesion formation following
enteropathogenic Escherichia coli and Shiga toxin-producing E. coli.
Infection and Immunity: 2001: 69: 7152-7158.
Jones N, Day A, Jennings H, Shannon P, Galindo-Mata E, Sherman P:
Enhanced disease severity in Helicobacter pylori-infected mice deficient
in Fas signalling. Infection and Immunity: 2002: 70: 2591-2597.
Jones N, Sherman P: Approaching Helicobacter pylori infection in
children: Level one evidence at last and a word of caution. Journal
of Pediatrics: 2001: 139: 622-623.
Jones NL, Perdue M, Sherman P, McKay D: Epithelial microbial
interactions. In: Methods in Biochemistry: 2002: 383-400.
Katz SL, McGee P, Geist R, Durie P: Factitious diarrhea: A case of
watery deception. Journal of Pediatric Gastroenterology and
Nutrition: 2001: 33: 607-609.
King S, Corey M, Major C, Poon A: Safety of the Canadian blood
supply in 1980-85: Using a pediatric cohort for risk assessment of
HIV infection. Paediatric Perinatal Epidemiology: 2001: 15: 58-73.
Kundhal P, Zachos M, Holmes JL, Griffiths AM: Controlled Ileal release
budesonide in pediatric Crohn’s Disease: Efficacy and effect on
growth. Journal of Pediatric Gastroenterology and Nutrition: 2001:
33: 167-170.
Leblac C, Pencharz P, Bar-Or O, Issenman RM, Nieman P, Pavilanis A,
Siemens R, Smith T, Westwood M: Healthy active living for children
and youth. Advisory Committee on Healthy Active Living of the
Canadian Paediatric Society. Paeditric Child Health: 2002.
McCloskey P, Tottle R, Selden C, Larsen F, Roberts EA, Hodgson HJF:
Modulation of hepatocyte function in an immortalized human
hepatocyte line following exposure to liver failure plasma. Artificial
Organs: 2002: 4: 340-348.
Ng VL, Sabla GE, Melin-Aldana H, Kelley-Loughnane N, Degen JL,
Bezerra JA: Plasminogen deficiency results in poor clearance of nonfibrin
matrix and persistent activation of hepatic stellate cells after
an acute injury. Journal of Hepatology: 2001: 35: 781-789.

Jones NL, Day, Galindo-Mata E, Jennings H, Shannon P, Sherman P:
Enhanced disease severity in Helicobacter pylori-infected mice deficient
in Fas signalling. Infection and Immunity: 2002: 70: 2591-2597.
Pencharz PB, Jackson R: There is no evidence of a primary defect in
energy metabolism in subjects with cystic fibrosis. Journal of
Pediatrics: 2002: 140: 498-499.
Hunt RH, Fallone C, van Zanten SV, Sherman P, and the Canadian
Helicobacter Study Group: Risks and benefits of Helicobacter pylori
eradication: current status. Canadian Journal of Gastroenterology:
2002: 16: 57-62.
Sajjan U, Corey M, Humar A, Tullis E, Cutz E, Ackerley C, Forstner J:
Immunolocalization of B. cepacia in the lungs of cystic fibrosis
patients. Journal of Medical Microbiology: 2001: 50: 535-546.
Sakac D, Zachos M, Lingwood CA: Purification of the testicular
galactolipid: 3'-Phosphoadenosine 5'-Phosphosulfate Sulfotransferase.
Journal of Biological Chemistry: 2001: 267: 1165-1169.
Sherman P, Macarthur C: Current controversies associated with
Helicobacter pylori. Helicobacter pylori: Bacterial Pathogenesis and
Host Immune Response. Frontiers of Bioscience: 2001: 6: e187-e192.
Sy SKB, Tang BK, Pastrakujiic A, Roberts EA, Kalow W: Detailed
chacterization of mathematically dervied hepatic CYP1A1 activity
and expression using differential inhibition of ethoxyresorufin )deethylation
bvy fluvoxamine. European of Journal Clinical
Pharmacology: 2001: 57: 377-386.
Wagener JS, Farrell PM, Corey M: A debate on why my state (province)
should or should not conduct newborn screening for cystic fibrosis
(14th Annual North American Cystic Fibrosis Conference). Pediatric
Pulmonology: 2001: 32: 385-396.
Weinstein M, Babyn P, Zlotkin SH: An orange a day keeps the doctor
away: Scurvy in the Year 2000. Pediatrics: 2001: 108: 1-5.
Wilson DC, Rashid M, Durie PR, Tsang A, Kalnins D, Andrew M,
Corey M, Shin J, Tullis E, Pencharz PB: Treatment of vitamin K
deficiency in cystic fibrosis: effectiveness of a daily fab-soluable
vitamin combination. Journal of Pediatrics: 2001: 138: 851-855.
Yeung GS, Schauer CS, Zlotkin SH: Fractional zinc absorption using a
single isotope tracer. European Journal of Clinical Nutrition: 2001:
55: 1098-1103.
Yeung LTF, Roberts EA: Hepatitis B in Childhood - An update for the
pediatrician. Paediatric Child Health: 2001: 6: 655-660.
Zachos M, Griffiths AM: Enteral feeding and Crohn’s disease.
Academic Medicine: 2001: 17: 167-170.
Zachos M, Tondeur M, Griffiths AM: Enteral nutritional therapy for
inducing remission of Crohn's Disease. Cochrane Review: 2001: 3:
1-24.
Zachos M, Parkin P, Chait P, Babyn P: Neurofibromatosis type I
vasculopathy associated with lower limb hypoplasia. Pediatrics:
2001: 100: 395-398.
Zareie M, Singh P, Irvine E, Sherman P, McKay D, Perdue M: Monocyte
/ macrophage activation by normal bacteria and bacterial products:
implications for epithelial function in Crohn's disease. American
Journal of Pathology: 2001: 158: 1101-1109.
Ziadeh BI, Michaud AL, Saad NMR, Lewis BA, Rafii M, Pencharz PB,
Brenna JT: Enzymatic decarboxylation of tyrosine and phenylalanine
to enhance volatility for high precision isotope analysis. Anal of
Chemistry: 2002: 74: 479-483.
Zlotkin SH: Current issues for the prevention and treatment of iron
deficiency anaemia for the Indian. Indian Pediatrics: 2002: 39:
125-129.
Zlotkin SH, Arthur P, Antwi KY, Yeung G: Randomized controlled trial
of single versus three-times daily ferrous sulfate drops for treatment
of anaemia. Pediatrics: 2001: 108: 613-616.
Zlotkin SH: Adolescent Vegetarians: How well do their dietary patterns
meet the Healthy People 2010. Archives of Pediatrics and Adolescent
Medicine: 2002: 156: 426-427.
books and book chapters
Johnson-Henry K, Tompkins T, Sherman P: Lactobacillus species
inhibit adherence of diarrheagenic Escherichia coli to host epithelial
cells. Probiotics and Health, The Intestinal Flora (Roy D, eds).
Gouvenours Press: 2001: 86.
research and investigations
“Does physical activity make a difference to lung
health in Cystic Fibrosis?”. Coates A, Corey M: CCFF ($149,743
2000 - 2003).
“Evaluation of the ambulatory and Home Care Record
(AHCR)”. Guerriere D, Corey M, Coyte P, Tullis E, Ungar W: Medical
Research Canada ($134,492 2000 - 2002).
“Genetic Epidemiology of Cystic Fibrosis”. Corey M:
Canadian Cystic Fibrosis Foundation ($183,276 2000 - 2003).
“Patient/Biostatistics Core”. Core Project of NIH Center
Grant: “Molecular Basis of the Cystic Fibrosis
Phenotype”. Corey M: National Institute of Health (NIDDK)
($223,320 1999 - 2004).
An open-label, fixed dose study to assess the efficacy,
safety, and tolerability of the combination of intron a
plus Ribavirin in pediatric subjects with chronic
Hepatitis C (Study #SCH 18908). Roberts EA, Principal
Investigator in Toronto: Schering-Plough ($16,524 2000 - 2002).
Bioavailability of iron and zinc. Zlotkin SH: Canadian
Institute of Health Research ($270,291 2001 - 2004).
Bioavailability of NCAC in the neonatal piglet on TPN.
Ball RO, Pencharz PB: Canadian Institute of Health Research /
Industry ($97,770 2001 - 2005).
Bone mineral density after pediatric liver transplantation.
Ng VL: HSC Seed Grant ($16,320 2001 - 2002).
Cell signals: cell signalling in mucosal inflammation
and pain. Ellen R, Jones N, Shaman P: Canadian Institute of Health
Research ($300,000 2002 - 2005).
Characterization of a novel ATP binding cassette gene,
PRP, that is over expressed during hepatocarcinogenesis.
Furuya KN, Harper P: National Cancer Institute of Canada ($276,982
2001 - 2002).
Comparison Vaminolact and Neoven for the human
neonatal piglet model. Ball RO, Pencharz PB: Canadian Institute
of Health Research/Industry ($50,000 2002 - 2004).
Complete CFTR mutation characterization for Cystic
Fibrosis patients: A multi-center Canada Wide Study. Zielenski J, Coinvestigators:
PR Durie, L-C Tsui, M Corey: Canadian Cystic Fibrosis
Foundation ($64,000 2000 - 2003).
23

Correlation of non-invasive breath
test indices with intraluminal
measurements of lipid and starch
digestion in cystic fibrosis patients
with pancreatic insufficiency. Durie
PR, Tullis E, St. Michael's Hospital: Solvay
Pharmaceuticals ($152,108 1999 - 2001).
Critical factors in the initiation of
chronic intestinal inflammation.
Project 2: Role of the microbe. Sherman
P, Perdue M: Crohn's and Colitis Foundation
of Canada ($225,000 2001 - 2004).
Development of a blood collection
cassette. SH ZLOTKIN: Dept. of Health and
Human Services, Centre for Disease
Control ($300,074 2000 - 2003).
DHA in Cystic Fibrosis Mouse
Model. Peter Durie: Genzyme Corporation
(US $20,000 2001 - 2002).
Factors that influence disease
severity in cystic fibrosis - links
with the exocrine pancreas. Durie PR:
Canadian Cystic Fibrosis Foundation
($320,712 1999 - 2002).
GC- Combustion IRMS Maintenance.
Paul B. Pencharz, Steven Cunnane: CIHR
($143,968 2001 - 2005).
Genetics and Positional Cloning of
Shwachman Syndrome Defect.
Rommens J, Co-PI: CIHR ($101,905 2001 - 2003).
Hepatocellular copper disposition
and toxicity in a novel murine
model of Wilson Disease. Sarkar B,
Roberts E: Canadian Liver Foundation
($170,325 2001 - 2003).
Histidine treatment of hepatic
copper toxicosis in the toxic milk
mouse, a model for Wilson disease.
Roberts EA, Sarkar B (co-principal investigators):
HSC Research Institute, Seed Grant
Competition ($17,216 2000 - 2001).
Host epithelial cell responses to
attaching-effacing gastrointestinal
pathogens. Sherman P: Canadian
Institutes of Health Research ($679,517
2002 - 2007).
Host immune response to
Helicobacter pylori infection. Jones
NL: Canadian Institute of Health Research
($102,265 2001 - 2004).
24
Identification, prevention &
treatment of anaemia. Zlotkin SH:
Health Canada - First Nations Branch
($297,493 2001 - 2002).
Mechanisms of adhesion of
attaching and effacing
gastrointestinal bacterial
pathogens. Sherman P: Medical Research
Council of Canada ($72,000 1997 - 2002).
Mechanisms underlying
Helicobacter pylori disrupted
phagocytosis. Jones NL: Canadian
Association of Gastroenterology / CIHR /
Abbott ($60,000 2001 - 2002).
MITACS: Statistical Modeling and
Analysis of Complex Human Traits.
Bull S, Andrews D, Corey M, Darlington G, Escobar
M, Field C, Hooper, Morgan K, Tritcher D:
Networks of Centres of Excellence
($450,000 1999 - 2002).
MRC/Health Canada Fellowship
(Hepatitis C). Yeung L, Roberts EA
(supervisor): MRC/Health Canada Fellowship
(Hepatitis C) ($48,500 2000 - 2002).
Neuropsychological and
developmental outcome in children
with extrahepatic biliary atresia:
Pre and Post Transplantation.
Balthazor M, Co-Investigators - Ng VL, Roberts E:
Canadian Liver Foundation ($54,000 2001
- 2002).
Pathogenesis and prevention of H.
pylori infection. Jones NL: American
Digestive Health Foundation Research
Scholar Award. (US $150,000 2000 -
2003).
Pathogenesis of H. pylori. Jones NL:
University of Toronto Connaught New Staff
Matching Grant ($45,000 2000 - 2002).
Project 1 of NIH Center Grant:
“Molecular Phenotypes of Cystic
Fibrosis”. Durie P, Tsui L-C, Corey M, Sweezey
N, Zielenski J, Tullis E, Jarvi K: NIH (NIDDK)
($675,000 1999 - 2004).
Project 1: Molecular basis of the
cystic fibrosis phenotype (2P50
DK49096-06), (US Funds). Durie PR, Tsui
L-C (Co-Director): National Institutes of
Health SCOR Grant (NIDDK) ($675,000
1999 - 2004).
Project I: Disease Variability in Patients
with CFTR Gene Mutations. Durie PR
(Project I), Director (US$686,058/annum for
the whole project entitled: Molecular
Basis of the Cystic Fibrosis Phenotype
(2P50 DK49096): National Institutes of
Health ($135,000 2000 - 2004).
Studies in protein and energy
metabolism of neonates (1980-
1994) / Neonatal protein and
energy metabolism (1995-2000).
Pencharz P: Medical Research Council
($452,350 2000 - 2005).
Studies with Micronutrient
Supplements. Zlotkin SH: H.J. HEINZ
Company ($1,000,000 2001 - 2004).
The CF Phenotype: Establishing
diagnosis criteria for CF and related
disorders. Durie P, Tullis E: Canadian Cystic
Fibrosis Foundation ($110,000 2002 - 2004).
The effect of cystic fibrosis related
diabetes mellitus on protein
metabolism. Pencharz P, Tullis E: Canadian
Cystic Fibrosis Foundation ($123,000
2000 - 2003).
The effect of spinal cord injury on
energy expenditure. Pencharz, P:
Ontario Neurotrauma Foundation
($32,900 2000 - 2002).
The fate of ingested pancreatic
enzyme in patients with cystic
fibrosis and pancreatic
insufficiency. Durie PR: Organon Inc.
($107,530 1999 - 2001).
The role of T cells during H. pylori.
Jones NL: Hospital for Sick Children Seed
Grant ($28,750 2000 - 2002).
The use of indicator amino acid
oxidation to determine amino acid
requirements. Pencharz P, Ball R: Medical
Research Council ($554,560 2000 - 2005).
Training program in Clinical
Nutrition. Pencharz P B, Archer M, Anderson
H, Coates A, Darling P, O’Connor D, Wolever T:
Canadian Institute Health Research /
Operating / Training Program ($1,590,000
2002 - 2008).

faculty Oussama Abla, Maureen Andrew, Sylvain Baruchel, Victor Blanchette,
Eric Bouffet, Manuel Carcao, Helen Chan, David Dix, John Doyle, Yigal Dror,
Melvin Freedman, Ron Grant, Mark Greenberg, Hans Hitzler, Meredith Irwin,
Melanie Kirby, David Malkin, Patricia Massicotte, Ahmed Naqvi, Alberto Pappo,
Nancy Olivieri, Fred Saunders, Sheila Weitzman part-time Ibrahim Al-Hashmi,
Anthony Chan, Robert Lau, Aubrey Maze fellows Ibraheem Abosoudah,
Mohammed Al-Bakrah, Ebsebtesam Al-Oniezi, Khulood Al-Saad, Michael Capra,
Pimlak Charoenkwan, Lionel Chow, Manuel Diezi, Adam Gassas, Darren Hargrave,
Annie Huang, Anthony Juwah, Stefan Kuhle, Loretta Lau, Elaine Leung,
Alexander Liaschko, Aru Narendran, Paul Nathan, Shoshanna Revel-Vilk,
Marcus Schmugge, Anjali Sharathkumar, MacGregor Steele, Lillian Sung
The hematology/oncology/bone marrow transplantation
(BMT) cluster provides care for children with cancer and
non-malignant disorders of the blood, and children who
require stem-cell transplantation. Approximately 300
children (< 18 years of age) with newly diagnosed
cancer are registered in the pediatric oncology program
each year, representing 25% of all cases of pediatric
cancer seen in Canada annually. The BMT program is
the designated centre for pediatric stem-cell
transplantation in Ontario and have performed a total
of 70 transplants in the past year. Other very large
programs exist in bleeding and clotting disorders and in
the hemoglobinopathies e.g. sickle cell syndromes and
the thalassemias. The Division is one of the largest
institutional members of the Children's Oncology
Group (COG), and registered a total of 72 children on
COG initiated cooperative clinical trials in 2001,
representing a doubling of patient enrollment over
previous years and signalling a deliberate strategy to
enter, wherever possible, children with cancer on welldesigned
clinical trials.
Highlights of the past year include reorganization of the
cluster into five clinical sections under the leadership of
Dr. Victor Blanchette (hematology), Dr. John Doyle
(BMT), Dr. Eric Bouffet (neuroOncology), Dr. Alberto
Pappo (solid tumors) and Dr. Sheila Weitzman
(lymphoma/ leukemia). Dr. Alberto Pappo, a senior
pediatric oncologist with a career interest in pediatric
sarcomas, was recruited to the Division from St. Jude
Children's Research Hospital during the past year. Other
new physician recruits include Dr. Ahmed Naqvi
(clinician specialist) and three clinician
scientists/scientist-track physicians: Dr Eyal Grunebaum
(BMT) and Drs. Meredith Irwin and Annie Huang
26
Division of HAEMATOLOGY/ONCOLOGY
(pediatric oncology). Dr. Annie Huang, a member of the
NeuroOncology Section is one of the first two recipients
of awards in translational cancer research from the
Charles H. Hollenberg Translational Research Fund, a
partnership of Cancer Care Ontario, the CIHR and Eli
Lilly Canada.
The Division boasts an active international
clinical/research pediatric hematology/ oncology
fellowship program with 23 fellows in 2001. Research in
the Division is active and expanding. Highlights
included Canada Foundation for Innovation Awards to
Drs. David Malkin (Cancer Genetics) and Sylvain
Baruchel (New Agents and Innovative Therapies
Program), and a CIHR Award to Dr. Yigal Dror for basic
science studies in children with myelodysplasias and
rare pediatric bone marrow failure syndromes.
publications
Al-Kasim FA, Thornley I, Rolland M, Lau W, Tsang R, Freedman MH,
Saunders EF, Calderwood S, Doyle JJ: Single-centre experience with
allongeneic bone marrow transplantation for acute lymphoblastic
leukaemia in childhood: similar survival after matched-related and
matched-unrelated donor transplants. British Journal of
Haematology: 2002: 116: 483-490.
Allen U, Hebert D, Moore D, Dror Y, Wasfy S: Epstein-Barr virusrelated
post-transplant lymphoproliferative disease in solid organ
transplant recipients, 1988-97 a Canadian multicentre experience.
Pediatric Transplant: 2001: 5: 198-203.
Allen UD, Tellier R, Doyle J, Petric M, Wasfy S, Kumar P, Calderwood
S, Freedman M, Saunders F: The utility of plasma polymerase chain
reaction for human herpes virus-6 among pediatric bone marrow
transplant recipients: results of a pilot study. Bone Marrow
Transplantation: 2001: 28: 473-477.
Anton N, Massicotte P: Venous Thromboembolism in Pediatrics.
Seminars in Vascular Medicine: 2001: 1: 111-122.
Athale UH, Shurtleff S, Jenkins JJ, Poquette CA, Tan M, Downing JR,
Pappo AS: Use of reverse transcriptase polymerase chain reaction for
diagnosis and staging of alveolar rhabdomyosarcoma, Ewing's
sarcoma family of tumors, and desmoplastic small round cell tumor.
Journal of Pediatric Hematology Oncology: 2001: 23: 99-104.
Barash J, Pirogovski A, Livneh A, Brezniak N, Dror Y, Hahn T:
Colchicine treatment in familial Mediterranean fever: an indirect
effect on in vitro serum amyloid A secretion via leukocyte derived
factors. Clin Exp Rheumatol: 2001: 19: S76.
Bouffet E: Embryonal tumours of the central nervous system.
European Journal of Cancer: 2002: 38: 112-1120.
Carcao MD, Blanchette VS, Stephens D, He L, Wakefield CD, Butchart
S, Christie DJ, Rand ML: Assessment of thrombocytopenic disorders
using the platelet function analyzer (PFA-100). British Journal of
Haematology: 2002: 117: 947-951.
Carlotti CG, Salhia B, Weitzman S, Greenberg M, Dirks PB, Mason W,
Becker LE, Rutka JT: Evaluation of proliferative index and cell cycle
protein expression in choroid plexus tumors in children. Acta
Neuropathologica: 2002: 103: 1-10.

Chastagner P, Bouffet E, Grill J, Kalifa C:
What have we learnt from previous phase
II trials to help in the management of
childhood brain tumours. European Journal
of Cancer: 2001: 37: 1981-93.
Choi M, Massicotte P, Marzinotto V, Chan
AKC, Holmes J, Andrew M: the use of
alteplase to restore patency of central venous
lines in pediatric patients: a cohort study.
Journal of Pediatrics: 2001: 139: 152-156.
Cines D, Blanchette VS: Immune
thrombocytopenic purpura. New England
Journal of Medicine: 2001: 346: 995.
Dror Y, Durie P, Ginzberg H, Herman R,
Banerjee A, Champagne M, Shannon K,
Malkin D, Freedman MH: Clonal evolution
in marrows of patients with Schwachman-
Diamond syndrome: a prospective 5-year
follow-up study. Experimental Hematology:
2002: 30: 659-669.
Dror Y, Durie P, Ginzberg H, Herman R,
Banerjee A, Champagne M, Shannon K,
Malkin D, Freedman, MH: Clonal evolution
in marros of patients with Shwachman-
Diamond syndrome: A prospective 5-year
follow-up study. Experimental Hematology:
2002: 30: 659-669.
Dror Y, Freedman MH: Marrow cells from
Shwachman-Diamond syndrome patients
are characterized by abnormally increased
apoptosis mediated through the Fas
pathway. Blood: 2001: 97: 3011-3016.
Dror Y, Ginzberg H, Dalal I, Cherepanov V,
Downey G, Durie P, Roifman CM,
Freedman MH: Immune function in
patients with Shwachman-Diamond
syndrome. British Journal of Haematology:
2001: 114: 712-717.
Dupuis LL, Lau R, Greenberg ML: Delayed
nausea and vomiting in children receiving
antineoplastics. Medical and Pediatric
Oncology: 2001:37:115-21.
Fadoo Z, Naqvi SMA: Acute Myeloid
Leukemia in a Patient with
Thrombocytopenia with Absent Radii
Syndrome. Journal of Pediatric
Hematology/Oncology: 2002: 24: 134-135.
Fouladi M, Stempak D, Gammon J, Klein J,
Grant R, Greenberg ML, Koren G, Baruchel
S: Phase I trial of a twice-daily regimen of
amifostine with ifosfamide, carboplatin,
and etoposide chemotherapy in children
with refractory carcinoma. Cancer: 2001:
92: 914-923.
Fouladi M, Stempak D, Gammon J, Klein J,
Ping L, Grant RM, Greenberg M, Koren G,
Baruchel S: Phase I trial of a multiple-daily
dose regimen of amifostine with ICE
chemotherapy in children with refractory
cancer. Cancer: 2001: 92:4: 914-923.
Fouladi M, Stempak D, Gammon J, KleinJ,
Grant R, Greenberg ML, Koren G, Baruchel
S: Phase I Trial of a twice-daily regimen of
amifostine with ifosfamide, carboplatin,
and etoposide chemotherapy in children
with refractory carcinoma. Cancer: 2001:
92: 914-23.
Frappaz D, Marec-Berard P, Schell M, Bouffet
E, Rougier D, Blanchard P, Roussin G, Liger
A, Bergeron C, Philip T, Zucchinelli V:
School reinsertion of children treated for
tumors of the brain: experience of the
Leon-Berard Center. Bulletin Cancer: 2001:
88: 1222-1227.
Freedman J, Mody M, Lazarus AH, Dewar L,
Song S, Blanchette VS, Garvey MB, Ofosu FA:
Platelet activation and hypercoagulability
following treatment with porcine Factor
VIII (Hyate: C). American Journal of
Hematology: 2001: 69: 192.
Furman WL, Stewart CF, Kirstein M, Kepner
JL, Bernstein ML, King F, Vietti TJ, Steuber
P, Becton DL, Baruchel S, Pratt C: A
protracted intermittent schedule of
topotecan in children with refractory acute
leukemia: a Pediatric Oncology Group
study. Journal of Clinical Oncology: 2002:
20: 1617-1624.
Gesundheit B, Kirby M-A, Lau W,
Adbelhaleem M: Thrombocytopenia and
Megakaryocyte Dysplasia: A Side Effect of
Valproic Acid Treatment. Journal of
Pediatric Hematology/Oncology: July 2001.
Grant RM, Weitzman SS, Sherman CG, Sirkin
WL, Petric M, Tellier R: Fulminant
disseminated varicella zoster virus infection
without skin involvement. Journal of
Clinical Virology: January 2002: 24: 7-12.
Greenberg, Mark L: Childhood cancers and
the environment: Is there anything to
worry about? Paediatrics and Child Health:
2001: 6 : 728-729.
Hawkins DS, Anderson JR, Paidas CN,
Wharam MD, Qualman SJ, Pappo AS, Baker
S, Crist WM: Improved outcome for
patients with middle ear
rhabdomyosarcoma: A Children's Oncology
Group Study. Journal of Clinical Oncology:
2001: 19: 3073-3079.
Hill DA, Dehner LO, Gow KW, Pappo AS,
Crawford D, Pflaumer SM, Furman WL,
Hayes-Jordan AA, McDermott MB: Perianal
rhabdomyosarcoma presenting as a perirectal
abscess: A report of 11 cases. Journal of
Pediatric Surgery: 2002: 37: 576-581.
Irwin M, Seelan RS, van der Stoop P, Qian C,
Kaelin WG, Liu W: The Human p73
promoter: Characterization and
identification of functional E2F binding
sites. Neoplasia: 2002: 4: 195-203.
Irwin MS and Kaelin WG: p53 Family, p63
abd p73 Develop Their Own Identities.
Cell Growth and Differentiation: 2001: 12:
337-349.
Irwin MS and Kaelin WG: p63. In:
Encyclopedia of Molecular Medicine John
Wiley and Sons, New York: 2001.
Kadan-Lottick NS, Robison LL, Gurney JG,
Neglia JP, Yasui Y, Hayashi R, Hudson M,
Greenberg ML, Mertens AC: What do
childhood cancer survivors know about
their past diagnosis and treatment? The
childhood cancer survivor study. JAMA:
December 2001.
Klaassen RJ, Doyle JJ, Krahn MD, Blanchette
VS, Naglie G: Initial bone marrow
aspiration in childhood idiopathic
thrombocytopenia: Decision analysis.
Journal of Pediatric Hematology Oncology:
2001: 23: 511.
Kuhne T, Imbach P, Boton-Maggs PHB,
Berchtold W, Blanchette V, Buchanan GRe:
Newly diagnosed idiopathic
thrombocytopenic purpura in childhood:
an observational study. Lancet: 2001: 358:
2122-2125.
Laver JH, Mahmoud H, Pick TE, Hutchison
RE, Weinstein HJ, Schwenn M, Weitzman S,
Murphy SB, Ochoa S, Shuster JJ: Results of
a randomized phase III trial in children and
adolescents with advanced stage diffuse
large cell non-hodgkin's lymphoma: a
pediatric oncology group study. Leukemia
and Lymphoma: 2002: 43: 105-109.
Ma Z, Morris SW, Valentine V, Li M, Herbrick
JA, Cui X, Bouman D, Li Y, Mehta PK,
Nizetic D, Kaneko Y, Chan GC, Chan LC,
Squire J, Scherer, Hitzler JK: Fusion of two
novel genes, RBM15 and MKL1, in the t(1;22)
(p13;q13) of acute megakaryoblastic leukemia.
Nature Genetics: 2001: 28: 220-221.
Malkin D: Simian virus 40 and non-Hodkin
lymphoma. The Lancet: 2002: 359: 812-813.
Malkin D, Sexsmith E, Chilton-MacNeill S,
Diller L, Meister LA, Garcea RL: Tissuespecific
expression of SV40 in tumors
associated with the Li-Fraumeni syndrome.
Oncogene: 2001: 20: 4441-4449.
Mandel K, Dror Y, Poon A, Freedman MH:
Practical classification of pediatric
myelodysplasia (CCC system). Journal
Pediatric Hematology/Oncology, In Press:
2002: 24: 343-352.
Maru Barrera, Joanna Y.Y. Chung, Mark
Greenberg, Carly Fleming: Preliminary
Investigation of a Group Intervention for
Siblings of Pediatric Cancer Patients.
Children's Health Care: 2002: 31: 131-142.
McCarville MB, Spunt SL, Pappo AS:
Rhabdomyosarcoma in pediatric patients.
The good, the bad and the unusual.
American Journal of Roentgenology: 2001:
176: 1563-1569.
McCarville MB, Spunt SL, Skapek SX, Pappo
AS: Pictorial Essay: Synovial sarcoma in
pediatric patients. American Journal of
Roentgenology: 2002.
McDermid JM, Lalonde RG, Gray-Donald K,
Baruchel S, Kubow S: Associations between
dietary antioxidant intake and oxidative
stress in HIV-seropositive and HIV-
27

seronegative men and women. Journal of
Acquired Immune Deficiency Syndromes:
2002: 29: 158-164.
Meyer WH, Pratt CB, Poquette CA, Rao BN,
Parham DM, Marina NM, Pappo AS,
Mahmoud HH, Jenkins JJ, Harper J, Neel M,
Fletcher BD: Carboplatin/Ifosfamide
window therapy for osteosarcoma: Results
of the St. Jude Children's Research Hospital
OS-91 trial. Journal of Clinical Oncology:
2001: 19: 171-182.
Miller SL, Hoffer FA, Reddick WE, Wu S,
Glass JO, Gronemeyer SA, Haliloglu M,
Nikanorov A, Xiong X, Pappo AS: Tumor
volume or dynamic contrast-enhanced MRI
for prediction of clinical outcome of Ewing
sarcoma family of tumors. Pediatr Radiol:
2001: 31: 518-523.
Nathan PC, Chun K, Abdelhaleem M, Malkin
D: i(17)(q10) and t(4;12)(q12;p13) in a child
with acute myelogenous leukemia. Cancer
Genetics Cytogenetics: 2001: 131: 82-85.
Packer RJ, Boyett JM, Janss AJ, Stavrou T, Kun
L, Wisoff J, Russo C, Phillips P, Kieran M,
Greenberg M, Goldman S, Hyder D,
Heideman R, Jones-Wallace D, August GP,
Smith SH, Moshang T: Growth hormone
replacement therapy in children with
medulloboastoma: Use and effect on tumor
control. Journal of Clinical Oncology:
2001: 19: 480-487.
Pandya J, Valverde K, Heon E, Blaser S, Gallie
BL, Chan HSL: Predilection of
retinoblastoma metastasis for the
mandible. Medical Pediatric Oncology
2002: 38: 271-273.
Pappo AS, Grier HE: A tribute to Dr. Charles
Pratt. Journal of Pediatric
Hematology/Oncology: 2002: 24: 242-243.
Pappo AS, Lyden E, Brenneman J, Wiener E,
Teot L, Meza J, Crist W, Vietti T: Up-front
window trial of topotecan in previously
untreated children and adolescents with
metastatic rhabdomyosarcoma: An
Intergroup Rhabdomyosarcoma study
(IRSG). Journal of Clinical Oncology: 2001:
19: pp 213-219.
Pratt CB, Pappo AS: Management of
infrequent cancers of childhood. In:
Priniciples and Practice of Pediatric
Oncology (Pizzo PA, Poplack DG, eds).
Lippincott Williams and Wilkins,
Philadelphia, PA: 2002: 1149-1175.
Raney BR, Anderson JR, Barr FG, Donaldson
SS, Pappo AS, Qualman SJ, Wiener ES,
Maurer HM, Crist WM: Rhabdomyosarcoma
and undifferentiated sarcoma in the first
two decades of life: a selective review of
Intergroup Rhabdomyosarcoma Study
Group (IRSG) experience and rationale for
Intergroup Rhabdomyosarcoma Study V.
Journal of Pediatric Hematology Oncology:
2001: 23: 215-220.
28
Revel-Vilk S, Blanchette VS, Sparling C, Stain
AM, Carcao MD: DDAVP challenge tests in
boys with mild/moderate hemophilia A.
British Journal of Haematology: 2002: 117:
947-951.
Rodriguez-Galindo C, Billups CA, Kun LE,
Rao BN, Pratt CB, Merchant TE, Santana
VM, Pappo AS: Survival after recurrence of
Ewing's tumors. The St. Jude Children's
Research Hospital experience. Cancer:
2002: 94: 561-569.
Rodriguez-Galindo C, Daw NC, Kaste SC,
Meyer WH, Dome JS, Pappo AS, Rao BN,
Patt CB: Treatment of refractory osteosarcoma
with fractionated cyclosphosphamide and
etoposide. Journal of Pediatric
Hematology/Oncology: 2002: 24: 250-255.
Rodriguez-Galindo C, Hill DA, Onyekere O,
Pin N, Rao BN, Hoffer FA, Kun LE, Pappo
AS, Santana VM: Neonatal alveolar
rhabdomyosarcoma with skin and brain
metastases. Cancer: 2001: 92: 1613-1620.
Semple JW, Allen D, Rutherford M, Woloski
M, David M, Wakefield C, Butchart S,
Freedman J, Blanchette V: Anti-D (WinRho
SD '99) treatment of children with chronic
autoimmune thrombocytopenic purpura
stimulates transient cytokine/chemokine
production. American Journal of
Hematology: 2001: 69: 225.
Sharathkumar A, Thornley I, Saunders EF,
Calderwood S, Freedman MH, Doyle J:
Allogeneic bone marrow transplantation in
children with chronic myelogenous
leukemia. Journal of Pediatric
Hematology/Oncology: 2002: 24: 215-219.
Smith LM, Anderson JR, Qualman SJ, Crist
WM, Paidas CN, Teot LA, Pappo AS, Link
MP, Grier HE, Wiener ES, Brenneman JC,
Raney BR, Maurer HM, Donaldson SS:
Which patients with microscopic disease
and rhabdomyosarcoma experience relapse
after therapy? A report from the soft tissue
sarcoma committee of the Children's
Oncology Group. Journal of Clinical
Oncology: 2001: 19: 4058-4064.
Smithey BE, Pappo AS, Hill DA: C-kit
overexpression in pediatric solid tumors: A
comparative immunohistochemical study.
Journal of Surgical Pathology: 2002: 26:
486-492.
Spunt S, Thompson SJ, Pappo AS: Brain
metastases in pediatric solid tumors.
Forum: 2001: 11: 75-83.
Spunt SL, Anderson JR, Teot LA, Brenneman
JC, Meyer WH, Pappo AS: Routine brain
imaging is unwarranted in asymptomatic
patients with rhabdomyosarcoma arising
outside the head and neck region that is
metastatic at diagnosis. A report from the
Intergroup Rhabdomyosarcoma Study
Group. Cancer: 2001: 92: 121-125.
Stempak D, Dallas S, Klein J, Bendayan R,
Koren G, Baruchel S: Glutathione stability
in whole blood: effects of various
deproteinizing acids. Therapeutic Drug
Monitoring: 2001: 23: 542-549.
Sung L, Heurter H, Zokvic KM, Ford-Jones EL,
Weitzman SS, Freeman R, Dupuis LL,
Scheifele DW: Practical vaccination
guidelines for children with cancer. Paediatric
and Child Health: 2001: 6: 379-383.
Sung L, Weitzman S, Petric M, King SM: The
role of infections in primary hemophagocytic
lymphohistiocytosis: a case series and
review of the literature. Clinical Infectious
Disease: 2001: 33: 1644-1648.
Szymanski M, Petric M, Saunders EF, Tellier
R: Mycoplasma pneumoniae pericarditis
demonstrated by polymerase chain reaction
and electron microscopy. Clinical
Infectious Diseases: 2002: 34: e16-17.
Thornley I, Dror Y, Sung L, Wynn RF,
Freedman MH: Abnormal telomere
shortening in leucocytes of children with
Shwachman-Diamond syndrome. British
Journal Haematology: 2002: 117: 189-192.
Thornley I, Sutherland R, Wynn R, Nayar R,
Sung L, Corpus G, Kiss T, Lipton J, Doyle J,
Saunders F, Kamel-Reid S, Freedman M,
Messner H: Early hematopoietic
reconstitution after clinical stem cell
transplantation: evidence for stochastic
stem cell behaviour and limited
acceleration in telomere loss. Blood: 2002:
99: 2387-2396.
Valverde K, Pandya J, Heon E, Goh TS, Gallie
BL, Chan HSL: Retinoblastoma with central
retinal artery thrombosis that mimics
extraocular disease. Medical Pediatric
Oncology 2002: 38:277-279.
Valverde K, Senger C, Ngan B, Chan HSL:
Eccrine porocarcinoma in a child that evolved
rapidly from an eccrine poroma. Case
report and review of the Literature. Medical
Pediatric Oncology 2001: 37: 412-414.
Venkateswaran L, Rodriguez-Galindo C,
Merchant TE, Poquette CA, Rao BN, Pappo
AS: Primary Ewing tumor of the vertebrae:
Clinical characteristics, prognostic factors
and outcome. Medical and Pediatric
Oncology: 2001: 37: 30-35.
Wagner L, Neel MD, Pappo AS, Merchant TE,
Poquette CA, Rao BN, Rodriguez-Galindo
C: Fractures in pediatric Ewing sarcoma.
Journal of Pediatric Hematology Oncology:
2001: 23: pp 568-571.
Walterhouse D, Pappo A, Baker S, Parham D,
Anderson J, Donaldson S, Paidas C, Womer
R, Crist W: Rhabdomyosarcoma of the
parotoid region occuring in childhood and
adolescence: A report of the Intergroup
Rhabdomyosarcoma Study Group. Cancer:
2001: 92: pp 3135-3146.
Waye JS, Eng B, Patterson M, Carcao MD,
Chang L, Olivieri NF, Chui DH:
Identification of two new alphathalassemia
mutations in exon 2 of the
alpha 1-globin gene. Hemoglobin: 2001:
25: 391-396.

Waye JS, Eng B, Patterson M, Walker L,
Carcao MD, Olivieri NF, Chui DHK:
Hemoglobin H (Hb H) disease in Canada:
Molecular Diagnosis and Review of 100
Cases. American Journal of Hematology:
2001: 68: 11-16.
Weitzman S: Childhood malignancies. Your
Family Magazine: 2001: 31-34.
Weitzman S, Suryanarayan K, Weinstein, HJ:
Pediatric non-hodgkins lymphoma: clinical
and biologic prognostic factors and risk
allocation. Current Oncology Reports -
Pediatric Oncology: 2002: 4: 107-113.
Woods WG, Gao R-N, Shuster JJ, Robinson
LL, Bernstein M, Weitzman S, Bunin G,
Levy I, Brossard J, Dougherty G, Tuchman
M, Lemieux B: Screening of infants and
mortality due to neuroblastoma. New
England Journal of Medicine: 2002: 346:
1041-1046.
Wyatt-Ashmead J, Kleinschmidt-DeMasters B,
Mierau GW, Malkin D, Orsini E, Foreman
NK, McGavran L: Choroid plexus
carcinomas and rhabdoid tumors:
phenotypic and genotypic overlap.
Pediatric and Developmental Pathology:
2001: 4: 545-549.
Zaika A, Irwin M, Sansome C, Moll U:
Oncogenes Induce and Activate
endogenous p73 Protein. JBC: 2001: 276:
1310-11316.
ielenska M, Zhang SM, Ng K, Marrano P,
Bayani J, Ramirez OC, Sor Thorner P,
Greenberg M, Squire JA: Application of
comparative genomic hybridization,
spectral karyotyping, and microarray
analysis in the identification of subtypespecific
patterns of genomic changes in
rhabdomyos. Neoplasia: 2001: 1: 262-275.
BOOKS & BOOK CHAPTERS
Weitzman S: Complementary therapy and
paediatric cancer. In: Integrated Cancer
Care - holistic, complementary and creative
approaches (Barraclough J, ed). Oxford
University Press. 2001: 244-257.
RESEARCH AND INVESTIGATIONS
A Molecular Epidemiologic Case-
Control Study of Paediatric Brain
Tumours in Ontario. McLaughlin J, Jain M,
Malkin D, Rutka J, Wells, Greenberg M: NCIC
Canada ($492,427 2001 - 2004).
A Pharmacokinetic Study of
Prophylactic Doses of FRAGMIN in
Children who are at Increased Risk
for Thromboembolic Events. Maureen
Andrew, MD, Patricia Massicotte, MD., The
Hospital for Sick Children: Pharmacia Canada
Inc. ($335,637 2000 - 2002).
A Phase I study of carboplatin and
irinotecan in patients 1 to 21 years
of age with refractory solid tumors.
Baruchel S: Bristol-Myers Squibb ($59,625
2002 - 2003).
A prospective, randomized trial to
compare two regimens of prophylaxis
in older boys with severe
haemophilia A. Carcao MD, Blanchette V
(Co-Investigator), Feldman BM, Babyn P, Oh P,
Hedden D: Canadian Haemophilia Society
Research Program ($98,834 2001 - 2003).
Adenovirus-mediated p53 gene
transfer in aggressive sarcomas of
childhood. Malkin D: The Hospital for
Sick Children Research Institute Seed
Grant ($31,326 1999 - 2001).
Analysis of E2F-1 activation of p73.
Dr. Meredith Irwin, Dr. William Kaelin: National
Cancer Institute ($122,995 2001 - 2002).
Angiogenesis (bFGF, VEGF) and Ras
activation in neurofibromatosis
type 1 associated plexiform
neurofibroma. Baruchel S, Parkin P,
Gesundheit B, Becker L, Guha A: The Hospital
for Sick Children Seed Grant Competition
($37,500 2000 - 2002).
Apoptosis in IMFS. Yigal Dror: HSC
Research Institute Start-up Money from
Donor Directed Research Funds to
Division of Hematology/Oncology through
HSC Foundation. ($86,000 2000 - 2002).
Augmentation of fetal hemoglobin
in beta thalassemia. Olivieri NF:
National Institutes of Health - HL-97-013
(US Funds) ($1,457,100 1998 - 2003).
Brain Tumour Database Development.
E. Bouffet, S. Baruchel, N. Tariq, D. Hargrave:
B.R.A.I.N. Child ($35,000 2001).
Canadian Centre for Applied Cancer
Genetics. Malkin D, Weksberg R, Meyn S, Ray
P, Becker L, Rutka J, Yeger H, Zielenska M, Alman
B: Canada Foundation for Innovation
40%, OIT 40%, and Ballard Foundation
20% of total ($1,811,000 2002 - 2007).
Canadian Inherited Marrow Failure
Registry. Yigal Dror, 14 of 16 Heads of
Canadian Pediatic Hematology/Oncology
Program: HSC Foundation ($26,000 2002 -
2004).
Cancer Genetics Laboratory. Malkin D,
Weksberg R, Ellis J, Meyn S, Ray P, Zielenska M:
Ballard Foundation (non-competitive)
($550,000 2000 - 2004).
Cardiac iron loading and gene
expression. Olivieri NF: Heart and Stroke
Foundation of Canada T3157 ($147,000
1999 - 2002).
Cost-effectiveness of escalating
frequency factor VIII prophylaxis in
severe haemophilia A. Feldman BM,
Blanchette V (Co-Principal Investigator), Einerson
T, Rivard G, Israels S et al: CIHR (MRC/PMAC)
Health Program ($125,000 1999 - 2002).
Deferiprone therapy in sickle cell
disease. Olivieri NF: National Institutes of
Health - HL-96-001B (US Funds) ($525,000
1999 - 2002).
Dose escalation prophylaxis in boys
with severe haemophilia B. This
study is under consideration of funding
by Wyeth Ayerst/Genetics Institute.
Feldman B, Blanchette V (Co-Principal
Investigator), Rivard G, for the International factor
IX prophylaxis study group: Genetics Institute
($450,000 2001 - 2006).
Drug resistance genes in
retinoblastoma that failed therapy.
Chan HSL, DeBoer G, Gallie BL, Grogan TM, Cole
S, Deeley R, Ling V. Medical Research Council
($148,275 1998 – 2001).
E/beta Thalassemia: Study of the
natural history and response to
chemotherapy. Vichincky E, Olivieri NF:
National Institutes of Health - HL-96-001B
(US Funds) ($1,996,255 1998 - 2003).
Enhanced diagnosis of von
Willebrand disease (vWD) by
testing platelet activation and
function under varying shear rate
conditions. Leytin V, Freedman J, Blanchette V
(Co-Investigator): Aventis Behring Canada
Research Fund ($29,994 2001 - 2002).
Equipment and maintenance (flow
cytometry). Malkin D, Guidos C, Buchwald M,
Chamberlain J, Cohen A, Danska J, Dick J, Dosch
HM, Grinstein S, Letarte M, Rutka J: Medical
Research Council of Canada ($150,000
1998 - 2001).
29

Home chemotherapy for children
with cancer. Stevens B, Greenberg M (coinvestigators):
HSC Foundation ,
HealthCanada ($280,771 1998 - 2001).
hSNF5/INI1 in childhood leukemia.
Malkin D, Teshima I: Leukemia Research Fund
of Canada ($96,000 2000 - 2002).
Impact of Chelation on iron
transport and regulations. Templeton
D, Olivieri NF: Medical Research Council of
Canada MT-11270 ($240,000 1999 - 2004).
In vitro activity of squalene as a
chemopotentiating agent in
neuroblastoma cell lines and as a
cytoprotective agent in bone
marrow progenitors. Baruchel S, Das B:
Issho Genki International Limited
($88,050 2000 - 2002).
Incidence of Heparin Induced
Thrombocytopenia (HIT) in Pediatric
Patients: A Prospective Cohort
Study. Carcao M, Blanchette V, Rand M, Cox P,
Parshuram C, Leaker M: Hospital for Sick
Children Seed Grant ($8,670 2000 - 2002).
Induction of Anti-Leukemic Cellular
Immunity. Saunders EF, Narendran A:
Research Institute, The Hospital for Sick
Children ($31,580 2001 - 2003).
Interdisciplinary Health Research
Team (IHRT) in Musculoskeletal
Neoplasia. Bell RL, Andrulis I, Wunder J,
Alman B, Malkin D, Davies A, Greenberg ML, Bull
S, O'Sullivan B, Kandel R, Bramwell V, Hill R:
Canadian Institutes for Health Research
($7,140,000 2001 - 2006).
Investigations of recipient immunity
against allogenic leukoreduced
platelet transfusions. Semple JW,
Freedman J, Blanchette V (Co-Investigator): Canadian
Blood Services Research and Development
Program ($242,779 1999 - 2002).
Magnetic resonance imaging studies
of severe haemophilia A patients on
a randomized trial comparing two
regimens of recombinant factor VIII
prophylaxis. Carcao, MD, Blanchette V (Co-
Principal Investigator), Feldman BM, Babyn P:
Bayer Canada ($140,183 2001 - 2003).
Minimal residual disease in the
stem cell collections (pre and post
CD34 selection) of patients with
30
neuroblastoma that have
undergone high-dose therapy with
peripheral blood stem cell rescue.
Doyle J, Zielenska M, Thorner P, Sharathkumar A:
AMGEN ($5,000 2001 - 2002).
Molecular determinants of tumor
formation in Li-Fraumeni syndrome.
Malkin D: National Cancer Institute of
Canada ($336,000 2001 - 2004).
Multidrug resistance P170 and MRP
proteins in failure of pediatric
cancer therapy. Chan HSL, Ling V, Cole S,
Deeley R, Grogan TM, Sehested M, DeBoer G,
Scheper RJ, Ikegaki N, Gallie BL: NCIC Research
Grant ($295,224 1999 – 2002).
National Pediatric Cancer Pilot
Study. Ross J, Buckley JD, Robison LL, Pollock B,
Deapen D, Bhatia S, Malkin D, Hudson M, Krailo
M, Khayat A: National Institutes of Health
($417,964 2000 - 2002).
Neuro-Oncology Education
materials for Families. P. McGee, S.
Awery, S. Baruchel, E. Bouffet, D. Brownstone, P.
Dirks, N. Laperriere, T. Popov, B. Spiegler, C. Van
Halderen: Centre for Health Information
and Promotion, Hospital for Sick
Children, Toronto ($30,000 2001).
Non-transferring-bound plasma
iron and deferoxamine therapy.
Porter J, Olivieri NF: National Institutes of
Health - HL-97-013 (US Funds)
($1,305,480 1998 - 2003).
Pain in child health: An innovative,
transdisciplinary, cross-Canada
research training consortium.
McGrath PJ, Barr R, Baruchel S, Brown S, Camfield
C, Chambers C, Connolly J, Craig K, Dube L,
Feldman B, Finley G, Frager G, Gibbins S, Grunau
R, Harman K, Hetherington C, Howlett A, Johnston
C, Kenny N, Koren G, Langer J, Murray M,
Oberlander T, Ohlsson A, Otley A, Rathwell T, Salter
M, Schellinck H, Stevens B, Taddio A, Unruh A, Von
Baeyer C, Walker C: Canadian Institutes of
Health Research ($1,800,000 2002 - 2008).
Pharmacokinetics of Kogenate(R).
Carcao MD, Blanchette V (Co-Principal Investigator),
Lillicrap D: Bayer Canada ($85,505 2001).
Phase I trial of Temodal using an
extended continuous oral schedule
in recurrent pediatric brain tumors.
Baruchel S: Schering-Plough Canada
($90,000 1999 - 2002).
Pilot Study of Combination Therapy
of Temozolomide and Radiation
Therapy in brainstem glioma. S.
Baruchel, E. Bouffet, N. Tariq, D. Hargrave:
B.R.A.I.N. Child ($44,980 2001).
Pilot study of low dose
chemotherapy and cyclo-oxygenase-
2 inhibitor as anti-angiogenic
therapy in children with
progressive or recurrent solid
tumors. Baruchel S: Pharmacia
Corporation ($358,215 2001 - 2004).
Pilot study of low dose
Temozolomide and radiation in
brain stem glioma. Baruchel S:
BrainChild and Schering-Plough Canada
($32,000 2002 - 2004).
Prevention of platelet
alloimmunization in a human-PBL-
SCID mouse model. Lazarus A, Freedman J,
Blanchette (Co-Investigator): Canadian Blood
Services Research and Development
Program ($286,912 1999 - 2002).
Psychological Outcomes and Quality
of Life after Pediatric Bone Marrow
Transplantation. Saunders EF, Barrera M:
National Cancer Institute of Canada
($240,000 2000 - 2003).
Studies to determine the presence
of SV40 viral sequences and anti-
SV40 antibodies in patients with
osteosarcoma. Malkin D: Pediatric Oncology
Group of Ontario ($41,300 2000 - 2001).
The relationship between
parvovirus B19 infectionn and
prolonged febrile neutropenia in
children undergoing cancer
chemotherapy. Grant R., Sung L., Tellier R.,
Petric, M., Allen U., A, Matlow A, Feldman B:
Paediatric Consultants Research Grants ,
Hospital for Sick Children ($4,968 2002).
Validity of a modified standard
gamble technique to measure
quality of life in children with
significant medical conditions.
Feldman BM, Sung L, Ingber S, Young NL,
Blanchette V, Greenberg ML, Doyle JJ: Pediatric
Consultants ($4,988 2001 - 2002).
Various apoptosis pathways in SDS.
Yigal Dror: Shwachman-Diamond Canada
($79,000 2001 - 2003).

faculty Chaim Roifman, Adelle Atkinson, Amos Cohen, Eyal Grunebaum,
Sergio Grinstein part-time Gordon Donsky, David Hummel, Milton Gold,
Sasson Lavi, Howard Langer research associates Nigel Sharfe, Andrew
Freywald, Tom Grunberger, Peter Demin, Olga Rounova clinical & fellows
Siobhan Burns, Charlotte Miller, Maria Triassi, Suleiman Eisa, Yehuda Nofech-
Mozes, Amos Simon summer students Nicole Palumbo, Phil Sammut,
Daniel Hesse, Linda Quintal
The Division of Immunology/Allergy has recently
received recognition for it’s excellent national and
international contribution to the diagnosis of primary
immunodeficiency (PID) from the Jeffrey Modell
Foundation. This American foundation chose our
program as one of five sites world-wide and will provide
annual funding in perpetuity for the diagnosis of PID.
Teaching in our division has been assessed recently by
surveyors of the Royal College who gave full approval
and found no weaknesses in our training program.
Research in the division continues to flourish, by means
of funding and publications. Of special note, are the
discoveries concerning novel types of primary
immunodeficiency, the role of Eph receptor in the
immune system and the establishment of a PNP
deficiency knockout mouse model for gene therapy.
research and investigations
A randomized, double-blind, multicenter, parallel
group trial comparing the safety and efficacy of IGIV-
Chromatography. Roifman CM: Bayer Corporation ($320,071
1999 - 2001).
32
Division of IMMUNOLOGY/ALLERGY
Canadian Center for Primary Immunodeficiency. Roifman
CM: Jeffrey Modell Foundation ($37,000 in perpetuity 2001).
Chronic Lung disease in patients with
hypogammaglobulinemia treated with high dose IVIG.
Roifman CM: Aventis Behring Canada ($30,000 2000 - 2001).
Development of protein tyrosine kinase inhibitors for
treatment of leukemia. Roifman CM: HSC Translational
Research Grant ($100,000 1999 - 2001).
Development of Tyrphostins for treating leukemia and
lymphoma. Roifman CM: Lymphosign Inc. ($850,000 2001 -
2002).
Growth related tyrosine kinases in normal and
malignant lymphoid cells. Roifman CM: National Cancer
Institute of Canada (4th renewal) ($352,350 2000 - 2003).
Models of hematopoietic gene therapy. Roifman CM: CIHR
/Canadian Centres of Excellence for Genetic Disease - Genetics
Program ($350,000 1998 - 2005).
Molecular mechanisms of inborn immune-deficiencies
in T-cell development and signal transduction. Cohen A,
Roifman CM: CIHR (4th Renewal) ($450,126 1998 - 2004).
Risk of cancer in A-T families. Haile R, Roifman CM: National
Institute of Health (US Funds) ($141,448 1999 - 2003).
Role of Eph receptors in the immune system. Roifman CM:
Canadian Institute of Health Research (CIHR) ($300,084 2001 -
2004).
Subcutaneous immunoglobulin therapy for
hypogammaglobulinemia. A multicenter, international
study. Roifman CM: Aventis Behring ($75,000 2001 - 2002).

faculty Stanley E. Read - Chief, Upton D. Allen,
E. Lee Ford-Jones, Susan M. King, Anne G. Matlow,
Anne Opavsky part-time Ian Kitai cross
appointments William D. Biggar, Marvin Gans,
Susan Richardson, Sharon Walmsley, Lionel
Weinstein clinical fellows Maryanne Robb,
Fahad Al-Jobair, Marcela Hernandez
The Division of Infectious Diseases
plays a clinical and research
leadership role, locally, nationally
and internationally. We are a resource
for issues related to infectious disease
outbreaks, infection control and the
specialized areas of HIV, congenital
infections, management of infectious
complications of transplants, and the
ever-increasing problem of multidrug
resistant tuberculosis. Our TB
clinic, designed for appropriate
biocontainment, continues to expand.
In the area of education, our
Division continues to play a
leadership role in the Infectious
Diseases section of the Royal College
and in many areas of Continuing
Medical Education.
Infection Control studies include
the clinical and molecular
epidemiology of pediatric nosocomial
infections. Other continuing
research initiatives include
multicentered Pediatric HIV studies
related to maternal-to-child
transmission, and studies on new
antiretrovirals, vaccine studies and
studies on host susceptibility to
viral infections. Multicentered trials
on the diagnosis and prevention
of infections in transplant patients
are ongoing.
publications
Allen U, Alfieri C, Preiksaitis J, et al: Epstein-
Barr Virus infection in transplant recipients:
summary of a Canadian Workshop on
surveillance, prevention and treatment.
Canadian Journal of Infectious Diseases:
Division of INFECTIOUS DISEASES
2002: 13: 89-99.
Allen U, Conway B, Cassol S, Lapointe N,
Forbes J, King S, Gilmore J, Moore D, Read
S, Bortolussi R, Marshall C, Tobin J, Wells
G: High prevalence of mutations conferring
ZDV resistance and associated factors
among HIV-infected Canadian children.
Acta Paediatrica: 2001: 90: 823-824.
Allen UD, Hebert D, Tran D, Petric M, Tellier
R, Taylor G, Stephens D, West L, Superina
R, Dosch H, Wasfy S, Nelson S: Utility of
semiquantitative polymerase chain reaction
for Epstein-Barr virus among pediatric solid
organ transplant recipients with and
without post-transplant lymphoproliferative
disease. Clinical Infectious Diseases: 2001:
33: 145-150.
Allen UD, Tellier R, Calderwoord S, Wasfy S,
Petric M, Kumar P, Doyle J, Freedman M,
Saunders F: The utility of plasma polymerase
chain reaction for human herpes virus-6
among bone marrow transplant recipients;
results of a pilot study. Bone Marrow
Transplantation: 2001: 28: 473-477.
Birdi N, Duffy CM, Hosking M, Clulow MK,
Allen U, Petty RE: Rheumatic fever and
post-streptococcal reactive arthritis: a
Canadian survey of antibiotic prophylaxis.
Journal of Rheumatology: 2001: 28: 1681-
1688.
Bitnun A, King SM, Arneson C, Read SE:
Failure of prevention of perinatal HIV
Infectious Diseases. Canadian Medical
Association Journal: 2002: 166: 904-905.
Blanchette N, Smith ML, Fernandes-Penney
A, King S, Read S: Cognitive and motor
development in children with vertically
transmitted HIV infection. Brain and
Cognition: 2001: 1/2: 50-53.
DeMatteo D, Wells LM, Salter Goldie R, King
SM, Read SE: The 'family' context of HIV: a
need for comprhensive health and social
policies. AIDS Care: 2002: 14: 261-78.
Ford-Jones EL, Gold R: Pediatric Immunization
Update. Patient Care: 2002: 13: 54-74.
Embree J for the Infectious Diseases and
Immunization Committee, Canadian
Pediatric Society (U. Allen, member and
collaborator): It's time for a national
immunization strategy. Paediatric Child
Health: 2001: 6: 316-318.
Ford-Jones EL, Fearon M, Leber C, Dwight P,
Mysiak M, Cole B, Greene P, Artes S,
McGeer A, D'Cunha C, Naus M: Human
surveillance for West Nile Virus Infection,
Ontario, Summer-Fall, 2000 - Implications
for 2001. Canadian Medical Association
Journal: 2002: 166: 29-35.
Infectious Diseases and Immunization
Committee, Canadian Paediatric Society,
King SM: Bugs in our meal: food for
thought. Paediatrics & Child Health: 2001:
6: 214-222.
Infectious Diseases and Immunization
Committee, Canadian Paediatric Society,
King SM (liaison): Measles-mumps-rubella
vaccine and autistic spectrum disorder: a
hypothesis only. Paediatrics & Child
Health: 2001: 6: 387-397.
Infectious Diseases and Immunization
Committee, Canadian Paediatric Society (S.
King principal Author; U. Allen, member
and collaborator): Testing for human
immunodeficiency virus type 1 (HIV-1)
infection in pregnancy. Paediatric Child
Health: 2001: 6: 685-691.
Langley JM, Halperin S for the Infectious
Diseases and Immunization Committee,
Canadian Pediatric Society (U. Allen,
member and collaborator): Allergy to
antibiotics in children: perception versus
reality. Paediatric Child Health: 2002: 7:
233-237.
MA Opavsky, T Martino, M Rabinovitch, J
Peninger, C Richardson, M Petric, C
Trinidad, L Butcher, J Chan, PP Liu:
Enhanced ERK-1/2 activation in mice
susceptible to coxsackievirus-induced
myocarditis. Journal of Clinical
Investigation: 2002: 109: 1561-1569.
Marchessault V for the Canadian Infectious
Diseases and Immunization Committee (U.
Allen, member and collaborator): Historical
review of croup. Paediatric Child Health:
2001: 6: 721-723.
Matlow AG: Disinfection and Sterilization:
What, When and How. Sanitation Canada:
2002.
Panesar J, Higgins K, Forte V, Allen U:
Revisiting Mycobacterium bovis. J
Otolaryngology: 2002: 31: 58-99.
Read, S: Babies still being born with HIV in
Ontario. The Pediatric Infection Report:
2001: 5: 4.
Read, S: Needles in the park. The Pediatric
Infection Report: 2001: 5: 2.
Read, S: Prevention of maternal-to-child
transmission of HIV: A missed opportunity.
Catalyst: 2001: 6: 1.
Scheifele D, Halperin S, Vaudry W, Jadavji T,
Tan B, Law B, Le Saux N, Ford-Jones L Lebel
M, Moore D, Dery P, Morris R, Waters J,
Embree J, Walop W: Historic Low
Haemophilus Influenzae. Canada
Communicable Disease Report: 2001: 27:
149-150.
Stegenga J, Bell E, Matlow A: The role of
nurse understaffing in nosocomial viral
gastrointestinal infections on a general
pediatrics ward. Infection Control and
Hospital Epidemiology: 2002: 23: 133-136.
Sung L, Heurter H, Zokvic KM, Ford-Jones EL,
Weitzman SS, Freeman R, Dupuis LL,
Scheifele DW: Practical vaccination
guidelines for children with cancer. Pediatrics
and Child Health: 2001: 6: 379-383.
33

Sung L, Weitzman S, Petric M, King SM: The
role of infections of primary
hemophagocytic lymphohistiocytosis: Case
series and review of the literature. Clinical
Infectious Diseases: 2001: 33: 1644-1648.
Yeung LTF, King SM, Roberts EA: Mother-toinfant
transmission of hepatitis C virus.
Hepatology: 2001: 34: 223-229.
Books & Book Chapters
Blaser S, Jay V, Becker LE, Ford-Jones EL:
Neonatal Brain Infections (Chapter 10). In:
MRI of the Neonatal Brain (Rutherford, ed).
WB Saunders (Harcourt), London, U.K:
2002: 201-224.
Lynk AD, Kernested DL, Ford-Jones EL: Care
of high-risk children - young infants. In:
Infection Control in the Child Care center
and Pre-school (5th edition) (Donowitz L,
ed). Lippincott Williams & Wilkins,
Philadelphia: 2001: 23-30.
RESEARCH AND INVESTIGATIONS
A cost analysis of paediatric HIV
care in Canada: A pilot study. Allen U,
King SM, Read SE, Ungar W, Stephens D: Hospital
for Sick Children ($15,000 2000 - 2001).
A phase III randomized, controlled,
primary vaccination study to assess
the consistency of 3 production lots
of Smithkline Beecham Biologicals
combined Measles Mumps Rubella-
Varicella Vaccine 208136 (MeMuRu-
Oka). Ford-Jones EL, Corporate, multicenter:
Glaxo Smith Kline ($10,125 2001 - 2002).
A phase III randomized, controlled,
primary vaccination study to assess
the consistency of 3 production lots
of Smithkline Beecham Biologicals
combined Measles Mumps Rubella-
Varicella Vaccine 208136 (MeMuRu-
Oka). Smithkline Beecham Biologicals, Ford-
Jones EL (Toronto Vaccine Investigator):
Smithkline Beecham Biologicals
($143,000 2000 - 2001).
A randomized controlled trial of
once daily versus three times daily
tobramycin in combination with
piperacillin in febrile neutropenic
children undergoing bone marrow
transplantation. Doyle J, Sung L, Dupuis L,
Taddio A, Bliss B, Addollell M, Allen UD:
Research Institute, The Hospital for Sick
Children ($25,044 2000 - 2001).
34
A randomized, double-blind,
controlled study of an increased
caloric density infant formula and
its effect on growth and nutritional
status in HIV-infected infants. Gomez
MP, Read SE, McNeil P (Co-PI's, Nassau site): NIH
(US funds) ($120,000 2001 - 2002).
An HIV risk reduction intervention
for incarcerated youth in Canada.
Goldberg E, Millson P, Leslie K, Read S, Rivers SE,
Wormith D, Meen: OHTN ($600,000 1999 -
2003).
An open-label phase I/II study of
ABT-378/ritonavir in combination
with reverse transcriptase inhibitors
in HIV-infected children. Gomez, Read
SE, McNeil (co-PI's, Nassau site): Abbott (US
Funds) ($60,000 1999 - 2001).
Canada AIDS Russia Project. Flannagan
W, Read S, Salit I, Major C, Calzavara L:
Canadian International Development
Agency ($3,200,000 2001 - 2004).
Collection of RSV Isolates - please
note scientific review complete only -
also possible additional $3000 for
phase II. Ford-Jones EL and Petric M: Aventis
Pasteur ($6,500 2002 - 2003).
Do children with acute bronchiolitis
need chest radiographs? Schuh S, Dick
P, Lalani A, Allen U, Manson D, Babyn P, Stephens
D: Physician's Services Incorporated
($108,346 2001 - 2002).
Evaluating safety and risk of
antiretroviral drug exposure during
pregnancy for infants born to HIV
positive women in Ontario. King SM,
Koren G: Ontario HIV Treatment Network
(OHTN) ($175,000 1999 - 2002).
Evaluating safety and risk of
antiretroviral drug exposure during
pregnancy for infants born to HIV
positive women in Ontario. King SM,
Koren G: Glaxo-wellcome & Biochem-
Pharma ($100,000 1999 - 2003).
Evaluation of rapid HIV testing in
the delivery room. King SM, Guenter D,
Remis R, Read SE, Swantee C, Rachlis A, Walmsley
S, Gough K, Lefebvre J, Cohen H, Akhoury A,
Zlotnick Shaul R: Ontario HIV Treatment
Network ($200,000 2002 - 2004).
IMPACT (Immunizing monitoring
program active). Scheifele D, Halpern D,
Ford-Jones EL (local investigator for HSC): Health
Canada (administered through Canadian
Paediatric Society) ($39,974 2001 - 2002).
Implementation and evaluation of
RSV prophylaxis in Canada. Upton
Allen, HSC RSV Task Force: Abbott Canada
($39,429 2001 - 2002).
Low Birth Weight Infants: Epidemiology
of colonization with antimicrobial
resistant flora at hospital discharge
and on follow-up. Matlow A, O'Brien K:
The Hospital for Sick Children Seed Grant
($32,640 2001 - 2003).
Meningococcal surveillance. Scheifele
D, LeSaux N, IMPACT (Ford-Jones EL, member):
Canadian Paediatric Society ($3,316 2001
- 2002).
New Directions in EBV/PTLD
Collaborative Research in
Transplant Patients. Allen U, EBV and
Associated Viruses Collaborative Research Group:
Research Institute, Hospital for Sick
Children ($25,000 2002 - 2003).
Pneumococcal Disease Surveillance.
Scheifele D, IMPACT members (Toronto - Ford-
Jones: IMPACT/Canadian Paediatric Society
($2,959 2001 - 2002).
Pneumococcal Disease Surveillance.
Scheifele D, Halpern S, EL Ford-Jones (local
investgator): Health Canada through Canadian
Paediatric Society ($3,202 2002 - 2003).
Point Prevalence Surveillance
Project for Nosocomial Infections
within Selected Canadian Health
Care Institutions. Matlow A, Gravel D:
Health Canada: Canadian Nosocomial
Infections Surveillance Program ($3,000
2002 - 2003).
Polaris HIV Seroconversion Study.
Calzavara (PI), Major C, Myers T, Rachlis A, Read S,
Cassol S, Millson P, Logue K, Wallace E, Remis R,
McGee F, Corey C, Gough K, Graydon M, Tharao E,
Trow R, Crossman C: NHRDP, AIDS Prevention
and Community Action Program, Health
Canada, Glaxo Wellcome Positive Action
Fund ($1,486,456 1998 - 2001).

Polaris HIV Seroconversion Study.
Calzavara, Liviana, Major C, Myers T, Rachlis A,
Read S, Millson P, Logue K, Wallace E, Remis R,
McGee F, Corey P, Gough K, Graydon M, Tharao E,
Crossman, C: CIHR ($1,800,000 2001 - 2005).
Post-transplant lymphoproliferative
disease: a randomized trial of
ganciclovir prophylaxis among solid
organ transplant recipient. Humar A,
Allen UD, Hebert D: The Hospital for Sick
Children ($129,174 2000 - 2002).
Post-transplant lymphoproliferative
disease: clinical trials of ganciclovir
prophylaxis among solid organ
transplant recipients (parallel track
component). Allen U, Humar A, Hebert D and
the EBV/PTLD Collaboratrive Research Group:
Medimmune & Genesis Biopharmaceuticals
($56,000 2001 - 2002).
RCT of conventional amphotericin B
versus lipid amphotericin B (AmBisome).
Upton A, Bohn D, Parshuram C, Doyle J, Richardson
S, Grant R, Harvey E, Gilday D: Fujisawa Canada,
Inc. ($521,720 2002 - 2004).
Retrospective study to charcaterize
the effects of anti-retroviral therapy
on infants born to HIV infected
mothers. King SM, Arnold S, Degani N: The
Physicians' Services Incorporated
Foundation ($12,300 1999 - 2001).
Risk of hospitalization for RSV
lower respiratory infection among
infants born between 33-35 weeks'
gestation. Allen U, O'Brien K, Simmons B,
Newman C: Abbott Canada ($57,044 2001 -
2002).
Safety, tolerability and
immunogenicity of 3 different
formulations of a liquid hexavalent
combination vaccine (HR5I) Hib
conjugate, recombinant HBsAg,
diphtheria toxoid, tetanus toxoid,
5-component acellular perutssis
vaccine, and inactivated poliovirus
1, 2, 3) when administered to healthy
hepatitis B vaccine naive infants at
2, 4, 6 and 12-14 months. (Protocol
003-01). Merck & Co. Inc., Ford-Jones EL (HSC
Vaccine Investigator): Merck Frosst Canada &
Co. ($217,420 2001 - 2003).
Safety, tolerability and
immunogenicity of live attenuated
Oka/Merck Varicella vaccine in
patients undergoing solid organ
transplantation. Allen UD, Ward B,
Robinson J, Reymond D, Law B, Moore D, and
Canadian site investigators: Merck Frosst
Canada ($105,000 1999 - 2002).
35

faculty Keith Tanswell - Chief, Jaques Belik, Jonathan Hellmann, Andrew
James, Jae Kim, Aideen Moore, Christine Newman, Boriana Parvez, Hilary
Whyte scientific faculty Martin Post adjunct professor Xiaoping Lu
part-time Rosemary Moodie, Mount Sinai Hospital, Ann Jefferies, Edmond
Kelly, Karel O’Brien, Arne Ohlsson, Vibhuti Shah, Sharon Unger, Kin Fan Young
Tai, Sunnybrook and Women’s College, Elizabeth Asztalos, Shaheen Doctor,
Michael Dunn, Eugene Ng, Andrew Shennan, Brian Simmons, Martin Skidmore
fellows Bernard Barzilay, Maggie Shu, Michelle Gordon, Abhay Lodha,
Manoj Malviya, Steven Powell, Doug Campbell, Wadah Khriesat, Sachin Shah,
Anwar Asady, Catherine Taylor, Ethel Ying, Jelena Popovic, Yenge Diambomba,
Frank Bloomfield, Irfan Cheema, Sohail Cheema, Patrick McNamara, Robert
Jankov, Guy Millman, Prakash Satodia, Karthik Kulasekaran, Nilesh Senthe
The Division of Neonatology was pleased to welcome
Drs. Jaques Belik and Jae Kim to the full-time faculty at
the Hospital for Sick Children, and Drs. Shaheen Doctor
and Eugene Ng to the part-time faculty at the Sunnybrook
and Women’s College Health Sciences Centre.
The three level III NICUs at the Hospital for Sick
Children, Mt. Sinai Hospital and the Sunnybrook &
Women’s College Health Sciences Centre continue to
experience severe staffing difficulties, in parallel with
the increased demand for tertiary beds in the region and
a general increase in patient acuity within the units. All
three units have been further compromised over the last
year due to closures relating to outbreaks of infection.
Despite the best efforts of the three NICUs to minimize
patient transfers out of region during these outbreaks,
an increase in patient deferrals out of region and out of
country did occur. It was fortunate that the number of
Neonatal Transport teams, based at the Hospital for Sick
Children, had been recently increased, and were thus
able to cope with the increased demand for their services.
Active staff recruitment continues at all three centres.
The Division continues to train the largest number of
subspeciality trainees in Neonatology of any centre in
Canada. The recently observed and welcome increase in
the number of Canadian trainees continues. Various
members of the Division have obtained new or
continuing peer-reviewed research support for clinical
and laboratory research in the last year.
36
Division of NEONATOLOGY
publications
Aghajafari F, Murphy K, Matthews S, Ohlsson A, Amankwah K,
Hannah M: Repeated doses of antenatal corticosteroids in animals: a
systematic review. American Journal of Obstetrics and Gynecology:
2002: 186: 843-849.
Aghajafari F, Murphy K, Ohlsson A, Amankwah K, Matthews S, Hannah
ME: Multiple vs. single courses of antenatal corticosteroids for
preterm birth: a pilot study. Journal of the SOGC: 2002: 24: 321-329.
Aghajafari F, Murphy K, Willan A, Ohlsson A, Amankwah K, Matthews
S, Hannah M: Multiple courses of antenatal corticosteroids: a
systematic review and meta-analysis. American Journal of Obstetrics
and Gynecology: 2001: 185: 1073-1080.
Antunes, M, Belik, J: Critical analysis of the use of corticosteroids in
the neonatal period. Journal of Pediatrics (Rio J.): 2001: 77: S25-S31.
Asztalos E: Neuromotor development in your premature baby's first
year. Finding our way. Edited by Suzanne Lyons. Triplets, Quads &
Quints Association. 2001.
Asztalos E, Barrett JFR, Lacy M, Luther M: Evaluating 2 year outcomes
in twins

Kawasaki syndrome in association with
Epstein-Barr virus. Pediatrics and Child
Health 2001: 6(9): pp 627-630. C
Jacobs SE, Sokol J, Ohlsson A: Newborn
individualized developmental care and
assessment program: a systematic review
and meta-analyses. Journal of Pediatrics:
2002: 40: 699-706.
Jakobson L, Frisk V, Knight RM, Downie A,
Whyte H: The relationship between
preventricular brain injury and deficits in
visuomotor ability in extremly-low-birthweight
(

Pediatrics: 2002: 109: 399-403.
Van Aerde J, Shah V, Stark A, Ohlsson A,:
Postnatal corticosteroids to treat or prevent
chronic lung disease in preterm infants.
Pediatric and Child Health: 2002: 7: 20-28.
Yuan S, Hannam V, Belcastro R, Cartel N,
Cabacungan J, Wang J, Diambomba Y,
Johnstone L, Post M, Tanswell AK: A role
for platelet-derived growth factor-BB in rat
post-pneumonectomy compensatory lung
growth. Paediatric Research: 2002: 52: 25-33.
Yudin M, Asztalos E, Jefferies A, Barrett JFR:
The management and outcome of higher
order multifetal pregnancies - obstetric,
neonatal and follow-up data. Twins
Research: 2001: 4: 4-11.
research and investigations
“Teaching first year residents to
intubate does a structured instructional
program improve performance?”
AL Jefferies: Pediatric Consultants Research
Grant ($4,000 2000 - 2001).
“Teaching first year residents to
intubate does a structured
instructional program improve
performance?” AL Jefferies: American
Acadamy of Pediatrics/American Heart
Association ($3,940 2001 - 2002).
A dose-ranging study to assess the
effect of inhaled corticosteroids in
ventilator-dependent preterm
neonates. Dunn M, Shah V: 3M Canada
($46,650 2001 - 2002).
A multicentre randomized
controlled trial of amnioinfusion.
Fraser, W., Marcoux S, Goulet C, Ohlsson A,
Contandriopoulos A-P, Hofmeyr J, Petrou S,
Prendiville W: CIHR ($299,973 2002 - 2004).
An RCT: Two hemoglobin thresholds
for transfusion in newborns

preterm birth. Murphy KE, Hannah ME,
Ohlsson A, Saigal S, Kelly EN, Amankwah KS,
Matthews SG, Aghajafari F, Willan A, Dhindsa BL,
Gafni A, Hewson S: Medical Research Council
of Canada ($4,799,770 2000 - 2006).
Myosin light chain phosphatase and
the control of pulmonary and
systemic vascular resistance from
fetal to adult life. BELIK, J: Canadian
Institutes of Health Research Grant
($79,649 2001 - 2004).
NEC Steps Trial. Langer, J, Moore AM (Site
co-investigator): National Institutes of
Health ($750 US per patient 2002ongoing)
Neonatal renal venous thrombosis:
investigation of causation and
prognosis. Shah V, Shah P, Rosenblum N,
Andrew M, Perlman M: The Physicians'
Services Incorporated Foundation
($31,000 2001).
Pain in infants with neurologic
impairment: A program of research.
Stevens B, McGrath PJ, Camfield CS, Finley GA,
Howlet AA, Johnston CC, McKeeve PD, O'Brien K,
Ohlsson A: Medical Research Council of
Canada ($387,262 2000 - 2002).
Pain in infants with neurological
impairment: A program of research.
Stevens B, McGrath P, Johnston C, Franck L,
McKeever P, Ohlsson A, Finley A, Howlett A,
O'Brien K, Camfield C, Beyene J, Gibbins S, Breau
L: Bloorview Children's Hospital Foundation
for 2001-2002 ($9,105 2001 - 2002).
Pediatric Asthma Seminar Series.
Post M (Project Director): AstraZeneca, Merck,
GlaxoSmithKline ($18,000 2000-2002).
Predictors of neurodevelopmental
outcomes after neonatal
cardiopulmonary bypass. Sananes, R,
McCrindle B, Hornberger L, Kelly EN, Bohn D,
Williams W: Heart and Stroke Foundation
($124,882 2001 - 2003).
Randomized controlled trial of two
different lancet devices on pain
responses in term neonates
following a routine heel lance. Shah
V, Kulasekaran K, Taddio A, Perkins E, Kelly E:
Becton Dickinson ($5,000 2001).
Regulation of normal and oxygenmediated
aberrant postnatal lung
growth. Tanswell AK, Hu J: Grant #MOP-
37981 ($666,405 2000 - 2005).
Risk of Hospitalization for RSV
Lower Respiratory Infection Among
Infants Born Between 33 and 35
Completed Weeks Gestation. O’Brien
K (Co-investigator). Abbott Laboratories,
Limited. ($33,630 2001 - 2002).
Role of epithelial-mesenchymal
interactions in lung development.
Post M (PI): Canadian Institutes of Health
Research Operating Grant ($150,796/yr.
1999-2004).
Role of mechanical forces on lung
growth and differentiation. Post M
(PI): Canadian Institutes of Health
Research Operating Grant ($104,012/yr
1999-2004).
Salary Support. Jankov R: Canadian
Institute of Health Research Fellowship
($38,500 2001 - 2004).
Short bowel syndrome in surgical
neonates. De Silva N, Wales P., Lecce L, Moore
AM: The Hospital for Sick Children Seed
Grant ($8000 2002).
Strategic training initiative in
research in reproductive health
sciences. Fraser WD, Campbell M, Collet J,
Davidge S, De Koninck M, Dodds L, Dodin S, Fisher
W, Gagnon R, Grant A, Hatem-Asmar M, Heaman
M, Joseph K, Klein M, Labrecque M, Lambert R,
Lee S, Letourneau L, Leung P, Lye S, McCoshen J,
Moutquin J, Nisker J, Ohlsson A, Pierson R, Sauve
R, Smith G, Von Dadelszen P, Walker M, Wood S:
CIHR ($1,800,000 2002 - 2008).
Surveillance for severe neonatal
hyperbilirubinemia and screening
implications. Sgro M, Shah V: The Striving
for Excellence Fund ($10,000 2001 - 2002).
Surveillance for severe neonatal
hyperbilirubinemia and screening
implications. Sgro M, Shah, V: The
Physicians' Services Incorporated
Foundation ($41,500 2002 - 2004).
The Canadian preterm labour
nitroglycerin trial. Smith GN, Walker M,
O'Brien K, Ohlsson A, Windrim R: CIHR
($1,286,457 2000 - 2005).
The Pain Alleviation in Neonates
(PAIN) Trial. O’Brien K (Co-investigator): The
National Institute of Nursing Research,
NIH, USA ($147,443 2000 - 2003).
Thyroid hormone and infant visual
processing development. Rovet J,
Westall C, Asztalos E: Canadian Institute of
Health Research ($616,540 2001 - 2006).
Toronto Centre for Comparative
Models of Human Disease. Post M
(Project Group Leader) Canadian Institutes of
Health Research Awards ($51,928,502
2001 - 2002).
Two-year outcomes of infants and
mother enrolled in the Term Breech
Trial. Whyte HE, Hannah M, Saigal S, Hodnett
ED, Roger A, Hannah WJ, et al: Medical
Research Council of Canada ($305,858
1999 - 2004).
Workshop on Health Care Quality
Improvement. Lee SK, Moehr J, Baker R,
Ohlsson A: Canadian Institute of Health
Research (IHDCYH) ($10,000 2002).
39

The continued heavy clinical load and recent departure
of Drs Balfe and Arbus, contributed to a very busy year.
Nonetheless academic activities within the Nephrology
Division continued to thrive.
Dr Tino Piscione joined the division as a clinician
scientist, and will continue to study renal
morphogenesis – joining Dr Susan Quaggin’s laboratory.
Dr Norman Rosenblum successfully renewed his grant
with Kidney Foundation of Canada for study of renal
morphogenesis, and also developed a new model for
study of renal cystic dysplasia. In addition, he
spearheaded a successful application by a multicenter
group to obtain funding for clinician scientist training
from the Canadian Institute for Health Research. This
grant will be matched by funds from the Hospital for
Sick Children Foundation and the British Columbia
Research Institute for Children’s and Women’s Health.
New clinical activities included integration of the
Therapeutic Apheresis program under the Nephrology
divisional administration. Also, a plan has been devised
for initiation of the first Paediatric Home Nocturnal
Haemodialysis program in North America.
Dr Denis Geary was reappointed for a second 5-year
term as divisional leader.
publications
Allen U, Hebert D, Petric M, Tellier R, Tran D, Superina R, Stephens D,
West L, Wasfy S, Nelson S: Utility of semiquantitative polymerase
chain reaction for epstein-barr virus to measure virus load in
pediatric organ transplant recipients with and without
posttransplant lymphoproliferative disease. Clinical Infectious
Disease: 2001: 33: 145-150.
Goldman M, Hebert D, Geary DF: Management of steroid sensitive
nephrotic syndrome in children with type-1 diabetes. Pediatric
Nephrology: 2002: 17: 351-354.
Goldman M, Smith A, Shuman C, Caluseiu O, Wei CH, Steel L, Ray P,
Sadowski P, Squire J, Weksberg R, Rosenblum ND. Renal
abnormalities in Beckwith-Wiedemann Syndrome are associated
with 11p.15.5 uniparental disomy. J Am Soc Neph 13:2077-2084,
2002
Herz D, McLorie GA, Hafez AT, Rodgers-Herz C, El-Ghoneimi A,
Shuckett B, Merguerian P, Hebert D, Khoury AE: High resolution
ultrasound characterization of early allograft hemodynamics in
pediatric living related renal transplantation. The Journal of
Urology: 2001: 166: 1853-1858.
Karihaloo A, Karumanchi SA, Barasch J, Jha V, Nickel CH, Yang J,
Grisaru S, Bush KT, Nigam S, Rosenblum ND, Sukhatme VP, Cantley
LG. Endostatin regulates branching morphogenesis of renal
epithelial cells and ureteric bud. Proc Natl Acad Sci USA 98:12509-
12514, 2001.
40
Division of NEPHROLOGY
McLorie G, Farhat W, Khoury A, Geary D, Ryan G: Outcome analysis
of vesicoamniotic shunting in a comprehensive population. Journal
of Urology: 2001: 166: 1036-1040.
Morgan H, Khan I, Hashmi A, Hebert D, McCrindle B, Balfe JW:
Ambulatory blood pressure monitoring after renal transplantation.
Pediatric Nephrology: 2001: 16: 843-847.
Piscione TD, Phan T, and Rosenblum ND: BMP7 controls collecting
tubule cell proliferation and apoptosis via Smad1-dependent and -
independent pathways. Am J Physiol 280:F19-F33, 2001.
Piscione TD and Rosenblum ND. The molecular control of renal
branching morphogenesis: current knowledge and emerging
insights. Differentiation 70:227-246, 2002
books & book chapters
Geary DF, Harvey EA: Anticoagulation in Pediatric Hemodialysis. In:
Dialysis Therapy 3rd edition (Nissensen AR, Fine RN, eds). Hanley &
Belfus Inc, Philadelphia: 2002: 466-468.
research and investigations
A feasibility study of regional citrate anticoagulation
in pediatric hemodialysis. Harvey E, Morgan H, Geary D, Gajaria M:
Baxter Healthcare Corporation ($8,000 2000 - 2002).
Canadian Child Health Clinician-Scientist Program.
Rosenblum, ND: Canadian Institutes of Health Research ($300,000
2002 - 2008).
Canadian Child Health Clinician-Scientist Program.
Rosenblum, ND: British Columbia Research Institute for Children's
and Women's Health ($150,000 2002 - 2008).
Canadian Child Health Clinician-Scientist Program.
Rosenblum, ND: The Hospital for Sick Children Foundation
($300,000 2002 - 2008).
Control of renal branching morphogenesis: cellular
events and molecular mechanisms. Rosenblum ND: Canadian
Institutes of Health Research ($281,910 2000 - 2003).
Organ donation practise, retrospective analysis and
prospective evaluation of an organ donation consent
team approach to improve donation rates. Shemie S, Hebert
D, Cox P: The Kidney Foundation of Canada ($161,900 1998 - 2001).
Post-transplant lymphoproliferative disease: a
randomized trial of gancyclovir prophylaxis among
solid organ transplant recipients. Humar A, Allen U, Hebert D:
The Hospital for Sick Children Foundation ($129,174 2000 - 2002).
Safety, tolerability and immunogenicity of live
attenuated Oka/Merck varicella vaccine in patients
undergoing solid organ transplantation. Allen U, Hebert D,
Ward B, Robinson J, Raymond D, Law B, Moore D: Merck Frosst Canada
($105,000 1999 - 2002).

faculty O. Carter Snead III-Head, Brenda Banwell, Gabrielle deVeber, Robert
Haslam, William Logan, Daune MacGregor, Berge Minassian, Hiroshi Otsubo,
Wendy Roberts, Jay Rosenfield, Ingrid Tein, Jiri Vajsar, Shelly Weiss part-time
David Berbrayer, Joseph Bruni, Pam Cooper, Rosalind Curtis, Darcy Fehlings,
Cynthia Goldfarb, Karen Harman, Tammy Kagan-Kushnir, SML Kirkpatrick,
Jeffrey Kobayashi, John Lovering, Douglas McGreal, Gilbert Miller, Golda
Milo-Manson, Gordon Murphy, Peter Rumney, Diann Superina, Jentein Vermaat,
Fred Weinberg clinical fellows Abdullaziz Al Saman, Abdullaziz Al Ruwaishid,
Mubeen Fatima Rafay, Shahnaz Ibrahim, Adel Mahmoud, Evangeline Wassmer
epilepsy fellows Dave Clarke, Shahid Parvez stroke fellow Meredith
Golomb developmental fellows Cara Dosman, Carolyn Hunt, Nicola
Jones-Stokreef, Anne Kawamura, Tara Kennedy, Lana Weaver clinical research
fellow Michael Salman research fellow Shiro Chitoku residents Suad
Al-Otaibi, Rand Askalan, Asif Doja, Cecil Hahn, Jonathan Ponesse
The major foci of the clinical activities of the Neurology
Division are epilepsy, stroke, headache, neurometabolic
disease, neuromuscular disease, sleep disorders,
movement disorders, multiple sclerosis, autism,
developmental disorders and functional neuroimaging.
The Neurology Division has a Royal College accredited
training program in Child Neurology as well as
postdoctoral training programs in epilepsy, stroke, and
developmental pediatrics. The latter is in conjunction
with the Bloorview MacMillan Center. In addition, there
are a number of graduate students and postdoctoral
fellows in clinical neurophysiology and molecular and
cellular neurobiology. The research foci of the
Neurology Division is epilepsy (both clinical and basic
research), magnetoencephalography, stroke, dyslexia,
autism, burden of disease and quality of life, attention
deficit disorder/hyperactivity, muscular dystrophy,
multiple sclerosis, fatty acid oxidation disorders, and
molecular and cellular neurobiology.
publications
Akai T, Otsubo H, Pang EW, Rutka JT, Chitoku S, Weiss SK, Snead OC:
Complex central cortex in pediatric patients with malformations of
cortical development. Journal of Child Neurology: 2002.
Al-Rasheed A, Blaser S, Minassian B, Benson L, Weiss S: Cyclosporine A
neurotoxicity in a patient with idiopathic renal magnesium wasting.
Pediatric Neurology: 2001: 23: 353-356.
Banwell B. Clinicopathologic Conference: Loss of milestones and
failure to thrive in a 28 month old male. J Peds 2002; 140(6); 759-
765.
Chitoku S. Otsubo H, Harada Y, Jay V, Rutka, JT, Weiss S, Abdoll M,
Snead OC: Extraoperative cortical stimulation of motor function in
children. Pediatric Neurology: 2001: 24: 344-350.
Chow G, Banwell B, Clarke J. Late-onset GM2 gangliosidosis
presenting as burning dysesthesias. Pediatr Neurol 2001; 25:59-62.
Chuang NA, Otsubo H, Chuang SH: Magnetic resonance imaging in
pediatric epilspy. Top Magnetic Resonance Imaging: 2002: 13: 39-60.
Cortez MA, Cunnane SC, Snead OC: Brain sterols in the AY-9944 rat
model of atypical absence seizures. Epilepsia: 2002: 43: 3-8.
42
Division of NEUROLOGY
deVeber G: Editorial comment: Vascular occlusion in Moyamoya: a
multitude of etiologies? Stroke: 2001: 32: 1792.
deVeber G: Stroke and the child's brain: Syndromes, risk factors and
epidemiology. Current Opinions in Neurology. 2002; 15: 133-8.
Current Opinions in Neurology: 2002: 15: 133-8.
deVeber G, Andrew M, Adams C, Canadian Ischemic Stroke Registry
(DL MacGregor): Cerebral sinovenous thrombosis in children. New
England Journal of Medicine: 2001: 345: 417-423.
Donner EJ, Smith C, Snead OC: Sudden unexpected death in pediatric
epilepsy. Neurology: 2001: 57: 430-434.
Fehlings D, Weiss S, Stephens D: Frequent night awakenings in
preschool children referred to a sleep disorders clinic: The role of nonadaptive
sleep associates. Children's Health Care: 2001: 30: 43-55.
Fernandes MA, McAndrews MP, Logan W, Smith ML, Crawley A,
Mikulis D: Determining language lateralization in children:
Comparison of fMRI and dochotic listening. Brain and Cognition:
2001: 47: 200-203.
Golomb M, MacGregor D, Domi T, Armstrong D, McCrindle B,
Mayank S, deVeber G: Presumed pre- or perinatal arterial ischemic
stroke: Risk factors and outcome. Annals of Neurology: 2001: 50:
163-168.
Golomb MR, Weiss SK, Ibrahim SH, deVeber GA: A 15-year-old boy
with central nervous system vasculopathy presenting with the
dysarthria-clumsy hand syndrome. Journal of Child Neurology:
2002: 7: 241.
Hogema BM, Taylor M, Jakobs C, Schutgens RBH, Froestl W, Snead
OC, Grompe M, Gibson KM: Pharmacologic rescue of lethal seizures
in mice deficient for succinate semialdehyde dehydrogenase. Nature
Genetics: 2001:29:212-216.
Jaaskelainen SK, Juel VC, Udd B, Villanova M, Liguori R, Minassian
BA, Falck B, Niemi P, Kalimo H: Electrophysiological findings in Xlinked
kk myopathy with excessive autophagy. Annals of Neurology:
2002: 51: 648-652.
Kolski H, Otsubo H: The Landau-Kleffner syndrome. Advance
Experience Medical Biology: 2002: 497: 195-208.
Kozer E: How high can we go with phenytoin? Therapeutic Drug
Monitoring: 2002:24: 386-9.
MacGregor D: Vertigo. In: Pediatrics in Review: 2002: 10-16.
Mackay M, Weiss S, Snead OC: What is (are) the rational basis(es),
other than trial-and-error experience for current medical treatments?
International Review of Neurobiology Series Academic Press: 2002:
49: 157-184.
McAdam L, Blaser S, Banwell B. Pediatric tumefactive demyelination:
Case series and review of the literature. Pediatr Neurol 2002; 26(1);
18-25.
Ochi A, Otsubo H: Clinical application of EEG dipole analysis.
Pediatric Medicine (Japanese): 2002: 5: 101-106.
Ochi A, Otsubo H, Honda Y, Hara Y, Sharma R, Rutka JT, Chuang SH,
Kamijo K, Kiyuna T, Yamazaki T, Snead OC III:
Electroencephalographic dipoles of spikes with and without
myoclonic jerks caused by epilepsia partialis continua. Journal of
Child Neurology: 2002: 17: 127-131.
Ochi A, Otsubo H, Sharma R, Hunjan A, Rutka JT, Chuang SH, Kamijo
K, Yamazaki T, Quint P, Kurelowech L, Sobel DF, Aung MH, Snead
OC: Comparison of electroencephalographic dipoles on interictal
spikes from prolonged scalp video-electroencephalographic and
magnetoencephalographic dipoles from short-term recording in
children with extraptemporal lobe epilepsy. Journal of Child
Neurology: 2001: 16: 661-667.
Otsubo H, Chitoku S, Ochi A, Jay V, Rutka JT, Smith ML, Elliott IM,
Snead OC: Malignant rolandic-sylvian epilepsy in children:
Diagnosis, treatment and ouctomes. Neurology: 2001: 57: 590-596.
Otsubo H, Ochi A, Elliott I, Chuang SH, Rutka JT, Jay V, Aung M,
Sobel DF, Snead OC III: MEG predicts epileptic zone in lesional

extrahippocampal epilepsy: 12 pediatric
epilepsy surgery cases. Epilepsia: 2001: 42:
1523-1530.
Persad V, Cortez MA, Snead OC: A chronic
model of atypical absence seizures: Studies
of developmental and gender sensitivity.
Epilepsy Research: 2002: 48: 111-119.
Roberts W, Weaver L, Brian J, et al: Repeated
doses of porcine secretin did not improve
symptoms, language or cognitive
functioning in children with autism or
autism spectrum disorder. Evidence-Based
Mental Health, 2002: 2002: 5: 22.
Salman M, Kirkham F, MacGregor D: Idiopathic
“benign” intracranial hypertension: A case
series and a review. Journal of Child
Neurology: 2001: 16: 465-470.
Salman M, MacGregor D: Should children
with Bell's palsy be treated with steroids? A
systematic review. Journal of Child
Neurology: 2001: 16: 565-568.
Shinar Y, Ben-Zeev B, Brand N. Lahat H,
Gross-Zur V, MacGregor D, Bahan T,
Kastner DL, Pras E: A common ancestral
haplotype in carrier chromosomes from
different ethnic backgrounds in vacuoliting
megalencephalic leukoencephalopathy
with subcortical cysts. Journal of Medical
Genetics: 2002: 39: 54-57.
Williams S, Basualdo-Hammond C, Curtis R,
Schuller R: Growth retardation in children
with epilepsy on the ketogenic diet: A
retrospective chart review. Journal of the
American Dietetic Association: 2002: 102:
405-407.
Wong CG, Snead OC: The GABAA receptor:
Subunit-dependent functions and absence
seizures. Epilepsy Currents: 2001: 1: 1-5.
Woo CLF, Chuang SH, Becker LE, Jay V,
Otsubo H, Rutka JT, Snead OC: Radiologicpatholgic
correlation in focal cortical
dysplasia and hemimegalencephaly in 18
children. Pediatric Neurology: 2001: 25:
295-303.
Xiang J, Chuang SH, Wilson D,, Otsubo H,
Pang E, Holoka S, Sharma R, Ochi A,
Chitoku S: Sound motion evoked magnetic
fields. Clinical Neurophysiology: 2002: 113:
1-9.
Xiang J, Wilson D, Chuang SH, Otsubo H,
Ishii R: Neuromagnetic spectral distribution
of implicit processing of words.
Neuroreport: 2001: 18: 3923-3927.
books & book chapters
Mackay M, Weiss S, Snead OC: Treatment of
infantile spasms: An evidence based
approach. In: Epilepsy, Infantile Spasms
and Developmental Encephalopthy
(Schwartzkroin P, Roh J, eds). Review of
Neurobiology Series, Academic Press, New
York: 2002: 157-184.
Martein K, Snead OC: Adrenocorticotropin
and Steriods. In: The Treatment of Epilepsy:
Principles and Practice (Wyllie E, ed).
Williams and Wilkins, New York: 2001:
969-978.
Vajsar J: Disorders of neuromuscular
transmission. In: Current Management in
Child Neurology, 2nd Edition (Boiago Lea,
ed). B C Decker Inc Publisher, Hamilton,
ON: 2001.
research and investigations
A population based cohort study of
incidence, health care, utilizations
and outcomes in children with
stroke. deVeber GA, Teresa To: Canadian
Institute of Health Research ($199,152
2002).
“Outcome evaluation of pediatric
acquired brain injury: An
examination of 900 client database
including five-year follow-up
study.” Johnson P, deVeber G, Anderson P,
Curtis R: Bloorview MacMillan Foundation
($97,954 2002 - 2003).
A double blind placebo controlled
randomized clinical trial of
fluroxamine and sertraline in
childhood autism. Sunita V, Roberts W,
Balthazor M: Ontario Mental Health
Foundation ($114,688 2000 - 2003).
A multi-centre, double-blind,
placebo-controlled, randomized
trial and an open-label long-term
tolerability trial of zolmitriptan
(ZOMIGTM). MacGregor DL: Astra-Zeneca
Pharmaceuticals Inc. ($15,500 1999 - 2002).
A randomized double-blind trial of
creatine monohydrate in patients
with muscular dystrophy
(DMD/BMD and DM). Tarnopolsky M,
Vajsar J, Biggar D: Muscular Dystrophy
Association USA ($138,000 2000 - 2002).
Atypical Absence Epilepsy: GABAB.
Snead OC, Cortez M, Francis E: Canadian Institute
of Health Research ($330,000 2000 - 2003).
Canadian Stroke Network: Theme
II, optimizing acute stroke care in
Canada (7 year grant) (no funds
committed to Gabrielle deVeber).
Hakim A, deVeber G: Networks of Centres of
Excellence, Canadian Government
($4,700,000 2000 - 2007).
Carnitine-responsive
cardiomyopathy and the highaffinity
carnitine transporter
defect. Tein I: Heart and Stroke
Foundation of Canada Grant ($25,000
2001 - 2002).
Central nervous system recovery
following paediatric ischemic
stroke evaluated by functional MRI.
Logan W, deVeber G: Hospital for Sick
Children Paediatric Consultants Grant
($10,000 1999 - 2001).
Cerebral palsy research. Logan WJ:
Grotto Cerebral Palsy Foundation
($90,000 1996 - 2001).
Characterization of patients with
childhood autosomal recessive
muscular dystrophy. Vajsar J: The
Hospital for Sick Children Foundation
($37,900 2000 - 2003).
Commercial applications of gene
discovery in the progressive
myoclonus epilepsies. Minassian B:
Canadian International Development
Agency ($30,000 2002 - 2003).
Early development of Williams
syndrome. Anderson P, Balthazor M, Roberts
W, Weksberg R, Cytrynbaum C: The Hospital
for Sick Children Research Institute
($25,800 2000 - 2001).
Examination of auditory function in
children using MEG. Pang, E., Otsubo,
Hiroshi, Sharma, R., Chuang, S: Seed Grant at
the Hospital for Sick Children ($19,210
2002 - 2003).
Exploring the gap between
knowledge and behaviour: A
qualitative study of clinician action
following an educational
intervention. Kennedy T, Lingard L.,
Rosenfield J, Roberts W: CIHR-ACMC ($19,492
2001 - 2002).
Generation of carnitine transporter
OCTN1 knock-out mouse. I Tein:
Hospital for Sick Children Foundation
Grant ($60,000 2002 - 2003).
Genetics of ADHD. Barr C, Schachar R,
Roberts W, Malone M, Tannock R, Kennedy J:
Psychiatry Endowment Fund, The Hospital
for Sick Children ($12,680 1997 - 2002).
Genotype and phenotype of
brainstem injury in autism. Rodier PM,
Figlewicz DA, Hyman S, Bryson S, Miller M,
Stanton M, Gudas L. (Roberts W, Buncic R -
consultants): National Institute for Health
(NIH) ($5,527,893 1997 - 2002).
Hydrocephalus: MRI morphometric
and cognitive correlations. Dennis M,
MacGregor D: NIH ($1,131,141 1998 - 2003).
Identifying early markers of risk in
43

infant siblings of children with
P.D.D. Zwaigenbaum L, Szatmari P, Bryson S,
Roberts W: Hospital for Sick Children
Foundation ($129,958 2000 - 2002).
Identifying early signs of autism: A
study of infant siblings. Zwaigenbaum
L, Szatmari P, Bryson S, Roberts W: National
Alliance Autism Research ($250,000 2001
- 2004).
Impact of intracranial bleeds on the
health and quality of life of boys
with hemophilia. Feldman B, Blanchette V,
Barnes M, Logan W: Aventis Pharm Inc
($29,788 2001).
Investigation of genetic factors in
attention deficit hyperactivity
disorder. Barr C, Schachar R, Roberts W,
Malone M, Tannock R, Kennedy J: Medical
Research Council ($592,095 1997 - 2002).
Localization brain language in a
normal pediatric population: A
comparison of functional magnetic
resonance imaging (fMRI) and
magnetoencephalography/magnetic
source imaging (MEG/MSI)
techniques. Logan W, Pang E, Otsubo H:
Pediatric Consultants, Research Proposal
at the Hospital for Sick Children ($5,000
2002 - 2003).
Localizing brain language areas in
a normal paediatric population: A
comparison of functional magnetic
resonance imaging (fMRI) and
magnetoencephalography/magnetic
source imaging (MEG/MSI)
techniques. Logan WJ, Pang E: Paediatric
Consultants ($5,000 2001 - 2002).
MEG normal data of children:
functional mapping somatosensory
cortex. Xiang J, Otsubo H, Wilson D, Holowka S,
Sharma R: Seed Grant - The Hospital for
Sick Children ($19,210 2002 - 2003).
mGluR4-mediated mechanisms of
absence seizures. Snead OC, Hampson D:
Medical Research Council of Canada
($249,390 1999 - 2002).
Mitochondrial Encephalomyopathies -
MELAS Dichloroacetate Trial. De Vivo
DC, Tein I (External Medical Review and Advisory
Committee): National Institutes of Health
Grant (NICHD) ($1,144,125 1999 - 2004).
Molecular Genetics and Functional
Studies in Lafora's Progressive
44
Myoclonus Epilepsy. Minassian B:
Canadian Institute of Health Research
($866,680 2000 - 2005).
Murine knockout of 4-hydroxybutyrate
aid. Snead OC, Gibson M: National Institute
Health ($504,000 2000 - 2004).
Neurobehavioural outcome of head
injury in children. (subcontract).
Dennis M, MacGregor DL: NINDS ($5,186,891
1998 - 2004).
Neuroimaging. Snead, OC: Ontario
Research Development Challenge Fund
($800,000 2001 - 2006).
Neurometabolic Research. Tein I:
Neurometabolic Research Fund ($5,000
1991 - 2002).
Neuropsychological and MRI
characteristics of pediatric multiple
sclerosis. Banwell B, Anderson P, Huber J,
Blaser S. Pilot Project Grant, Canadian
Multiple Sclerosis Society. ($25,720 2000-
2001)
New Defects in Polyamine
Metabolism. Hyland K, Baylor University,
Dallas, Texas, Tein I (Consultant): National
Institutes of Health Grant (NINDS)
($869,535 2001 - 2004).
Optimizing primary stroke
prevention in children with sickle
cell anemia (STOP II). Olivieri N,
MacGregor DL: National Institute of Health
($195,951 2000 - 2005).
Quality of Life for Children with
Long-Term Disabilities: Instrument
Development and Validation. Renwick
R., Friefeld S, Rosenfield J, Raphael D, Brown I:
The Hospital for Sick Children Foundation
($84,934 2000 - 2001).
Raising Serum Free Polyunsaturates
in Humans and Breath Acetone.
Cunnane S, Curtis R: Natural Sciences and
Engineering Research Council ($317,000
2001 - 2003).
Research Fellowship Award (Dr. M.
Frantseva). Snead, OC: Canadian Institute
of Health Research - Fellowship Award
($38,500 2001 - 2004).
Serotinergic Mechanisms in Atypical
Absence Seizures. Snead OC: Hospital
For Sick Children, Paediatric Consultants
($5,000 2001 - 2002).
Stroke Investigator Award “Research
Scholar” deVeber GA: Heart and Stroke
Foundation ($59,500/yr 2001 - 2006).
Stroke Investigator Award : Phase II,
Junior Faculty ($48,973/year). deVeber G:
Heart and Stroke Foundation ($59,973
1998 - 2001).
The Children's Stroke Project.
deVeber GA: Anonymous Children's
Foundation ($1,625,000 2001 - 2006).
The role of defective carnitine
transport in male infertility. I Tein:
Physicians' Services Incorporated
Foundation of Ontario Grant, ($164,000
2001 - 2003).
Use of creatine monohydrate in the
treatment of Duchenne Muscular
Dystrophy. Vajsar J: Research Institute,
Hospital for Sick Children, Seed Grant
2000 ($26,475 2000 - 2002).
Using event-related potentials
(ERP) to characterize auditory
processing deficits in Autism
Spectrum Disorders and Landau-
Kleffner Syndrome. Pang, Elizabeth W.,
Logan, WJ, Roberts, W: Cure Autism Now
Foundation ($80,000 2002 - 2004).
Virological studies in pediatric
multiple sclerosis. Banwell B, Al-Otaibi S,
Hewter H, Tellier R. Funded by a directed
donation to the HSC Foundation.
($8,000 2002)
Visual function in infants and
children treated with vigabatrin.
Westall C, Buncic R, Snead C, Logan W: Aventis
Pharm Inc ($100,000 2000 - 2001).
Visual function in infants and
children treated with vigabatrin.
Snead, OC (Co-PI), Westall C, Logan W: CIHR
($300,000 2001 - 2004).

faculty Patricia Parkin - Chief, Tara T. Baron, Stacey E. Bernstein, Paul T.
Dick, Jeremy Friedman, Beth D. Gamulka, Robert I. Hilliard, Dirk Huyer,
Bernice R. Krafchik, Colin Macarthur, Sanjay Mahant, Marcellina Mian, Elena
Pope, Michelle K. M. Shouldice, Susan E. Tallett, Michael Weinstein, Nancy
Young major part time Mark Feldman, Marvin Gans, Saul Greenberg,
Nhung T. C. Ho, Moshe M. Ipp, Sheila Jacobson, Christine Kalbfleisch, Michael
Peer, Norman Saunders, Darryl Wolski part time Anthony Barozzino, Glenn
B. Berall, Alan Berzen, Bonnie Cameron, Carlos E. Contreras, Susan J. Coombs,
William Davidson, Till A. Davy, Gordon J. Donsky, James M. Dorey, Katy Driver,
Anthony Duke, Robert Farber, Michelle Farine, Hyder H. Fazal, William
Feldman, Leona Fishman, John S. Freedman, Lee Ann Gallant, Hartley
Garfield, Colin Geft, Rose Geist, Sabine R.George, Morton Goldbach, Alan L.
Goldbloom, Stuart Gordner, Manuel S. Greenberg, Richard Hamat, James D.
Hilton, Anthony Y. T. Hui, Nicole G. Inch, Walter James, Anna D. Jarvis, Shahida
R. Khan, Ian C. Kitai, Beverley Kupfert, Howard M. Langer, Cinda B. S. Lee,
Eun S. Lee-Hong, Michael Lester, Leo Levin, Peter K. Lewin, Patricia M.
Linders, John S. Lovering, David C. Maresky, Aubrey H. Maze, Janette A. Milne,
Golda Milo-Manson, Paul Munk, Jack Newman, Raymond C. W. Ng, Eleazar
Noriega, Riccardo S. Olivares, Larry B. Pancer, Evangelia Papadouris, Jocelyne
Parent, Joseph S. Porepa, Percy Rajchgot, Colin A. Ramsay, Helene A. Richards,
Wendy Roberts, Jay D. Rosenfield, Antonina Saksznajder, Suzanne Schuh,
Clive J. Schwartz, Michael Sgro, David H. Shawn, Pryma N. Skowron, Janet A.
Star, Heshy Sturm, Robert E. Sutton, Joseph Telch, Lionel Weinstein, Jeffrey J.
Weisbrot, Sheldon A. Wise, Martin G. Wolfish honorary faculty Crawford
S. Anglin, Lionel B. H. Boxall, Michael Braudo, Andrew Chlebus, Andrew D.
Duic, Thomas J. Egan, Adelaide L. Fleming, Raphael Folman, Arthur I. Fremes,
Katerina Haka-Ikse, William B. Hanley, Jaya Islur, C.C. Ross Johnson, Martin H.
Kosoy, Bernard Laski, Mary R. A. MacDonald, Gilbert Miller, John D.M. Murray,
Chandrakant Shah, Donald A. Stewart, Peter G. Strachan, Martin G. Wolfish
fellows Susan Bannister, Catherine Birken, Louise Capra, Astrid Guttmann,
Patricia Lenane, Alison MacPherson, Amy Ornstein
The clinical programs of the Division of Paediatric
Medicine provide care to children admitted to the
Paediatric Medicine In-patient Unit and children
attending Ambulatory Clinics in Dermatology, Paediatrics,
and Suspected Child Abuse and Neglect (SCAN). The
Division underwent a successful 5-Year Review.
Faculty participate in education of trainees at all levels,
including medical students, paediatric residents and
fellows. Academic fellows have pursued post-graduate
training in Clinical Epidemiology and Medical
Education. This year’s Awards Day Celebration
recognized Dr. Beverly Kupfert, runner-up for the RHA
Haslam Pre-clerkship Teaching award, Dr. Marvin Gans
as a runner-up for the Clerkship Teaching Award, Dr.
Tara Baron as the winner of the Clerkship Teaching
Award, Dr. Jeremy Friedman, winner of the Harry Bain
Division of P AEDIATRIC MEDICINE
Teaching Award, Dr. Sheila Jacobson, runner up for the
Marvin Gerstein Teaching Award, Dr. Michael Peer,
winner of the Marvin Gerstein Teaching Award and
Dr. Michelle Shouldice, runner up for the Subspecialty
Teaching Award. Dr. Marcellina Mian was promoted to
full Professor.
Divisional research activities are broad and range from
studies of the management of common paediatric
problems, assessment of quality of life in developmentally
delayed children, evaluation of the hospitalist model,
and injury prevention. Members of the division have
supervised residents, fellows, and graduate students,
presented work at national and international meetings
(63 presentations), 39 published abstracts at national
and international scientific meetings, secured peerreviewed
funding for $2,342,920.00 and published 58
manuscripts in high-impact peer-reviewed clinical
journals. Dr. Moshe Ipp and Dr. Colin Macarthur
supervised Dr. Eyal Cohen who won the Core Pediatrics
Research Award at the Department of Paediatrics Annual
Awards Day. Dr. Astrid Guttmann was awarded a CIHR
Clinical Research Fellowship under the supervision of
Dr. Teresa To and Dr. Paul Dick. She was also the first
place winner of Subspecialty Paediatrics Clinical
Research at the Department of Paediatrics Annual
Awards Day. Dr. Alison Macpherson was awarded the
Best Oral Presentation at the 6th World Conference,
Injury Prevention and Control in Montreal.
publications
Bernstein S, Connolly B, Temple M, Weinstein M: Case Report:
Subcutaneous Emphysema following radiologically placed
percutaneous gastrostomy in an infant. American Journal of
Radiology: 2001: 177: 693-694.
Brunner HI, Silverman ED, To T, Bombardier C, Feldman BM: Risk
factors for damage in childhood-onset systemic lupus erythematosus:
Cumulative disease activity and medication use predict disease
damage. Arthritis and Rheumatism: 2002: 46: 436-444.
Coyte PC, Croxford R, Asche CV, To T, Feldman W, Friedberg J:
Physician and population determinants of rates of middle-ear
surgery in Ontario. Journal of the American Medical Association:
2001: 286: 2128-2135.
Dell S, To T: Breastfeeding and asthma in young children: Findings
from a population-based study. Archives of Pediatrics and
Adolescent Medicine: 2001: 155: 1261-1265.
Dell SDM, Parkin PC, Macarthur C: Childhood asthma admissions:
Determinants of short stay. Pediatric Allergy and Immunology:
2001: 12: 1-5.
Fitzpatrick KP, Sherman PM, Ipp M, Saunders N, Macarthur C:
Screening for celiac disease in children with recurrent abdominal
pain. Journal of Pediatric Gastroenterology and Nutrition: 2001: 33:
250-252.
45

Freedman SB, Dick PT, Marrocco A, Pirie J:
Predictors of bacterial meningitis in the
after haemophilus influenza era. Archives
of Pediatrics and Adolescent Medicine:
2001:155: 1301-1306.
Friedlander SF, Aly R, Krafchik B et al:
Terbinafine in the treatment of
Trichophyton tinea capitis: A randomized,
double-blind, parallel-group, durationfinding
study. Pediatrics: 2002: 109.
Goggin N, Macarthur C, Parkin PC:
Randomized trial of the addition of
ipratropium bromide to albuterol and
corticosteroid therapy in children hospitalized
because of an acute asthma exacerbation.
Archives of Pediatrics and Adolescent
Medicine: 2001: 155: 1329-1334.
Halman SI, Chipman M, Parkin PC, Wright
JG: Are seat belt restraints as effective in
school age children as in adults? A
prospective crash study. British Medical
Journal: 2002: 324: 1123.
Huertas-Ceballos A, Macarthur C, Logan S:
Pharmacological interventions for recurrent
abdominal pain (RAP) in childhood.
Cochrane Database: 2002: 1: 3017.
Ipp M: Diagnosis of purpura in children.
Patient Care: 2002: 13: 34.
Ipp M: Fifth disease. Patient Care: 2002: 13: 34.
Ipp M: Treating wheezing with Alupent.
Patient Care: 2002: 13: 34.
Ipp M: Vitamins for infants. Patient care:
2002: 13: 14-15.
Ipp M, Carson S, Petric M, Parkin PC: Rapid
painless diagnosis of viral respiratory
infection. Archives of Disease in
Childhood: 2002: 86: 372-373.
Jacka MJ, Cohen MM, To T, Devitt JH, Byrick
R: The use of and preferences for the
transesophageal echocardiogram and
pulmonary artery cathether among
cardiovascular anesthesiologists. Anesthesia
and Analgesia: 2002: 94: 1065-1071.
Macpherson AK, Parkin PC, To T: Mandatory
helmet legislation and children's exposure
to cycling. Injury Prevention: 2001: 7:
228-230.
Mahant S, Friedman J, Macarthur C: Renal
ultrasound findings and vesicoureteral
reflux in children with urinary tract
infection. Archives of Disease in
Childhood: 2002: 86: 419-421.
Mahant S, To T, Friedman J: Timing of voiding
cystourethrogram in the investigation of
urinary tract infections in children. Journal
of Pediatrics: 2001: 139:568-71.
McIsaac WJ, Goel V, To T, Permaul JA, Low
DE: Effect on antibiotic prescribing of
repeated clinical prompts to use a sore
throat score: Lessons from a failed
community intervention study. Journal of
Family Practice: 2002: 51: 339-344.
46
Pope E, Shouldice M: Drugs and Sexual
Assault. A Review. Trauma: 2001: 2: 51-55.
Rhodes AE, Goering PN, To T, Williams JI:
Gender and outpatient mental health
service use. Social Science and Medicine:
2002: 54: 1-10.
Schuh S, Coates AL, Binnie R, Allin T, Goia
C, Corey M, Dick PT: Efficacy of oral
dexamethasone in outpatients with acute
bronchiolitis. Pediatrics: 2002: 140: 27-32.
To T, Guttmann A, Dick P: Inpatient and day
surgery use by children in Ontario. ICES
Atlas Reports #4: Uses of Health Services
ICES, Toronto: 2001.
To T, Ungar W: Outpatient health services
use by children in Ontario. In: ICES Atlas
Reports #5: Uses of Health Services ICES,
Toronto: 2001.
Valverde K, Henderson M, Smith CR, Tallett
SE, Chan HSL: Typical and atypical
Carney's Triad presenting with malignant
hypertension and papilledema. Journal of
Pediatric Hematology/Oncology: 2001:
23:8: 519-524.
Weinstein M, Friedman J: A pale jaundiced
child with dark urine. Pediatrics and Child
Health: 2002: 7: 110-111.
Weinstein M, Friedman J: An Infant with
multiple fractures. Pediatrics and Child
Health: 2002: 7: 109-110.
Weinstein M, Babyn P, Zlotkin S: An orange a
day keeps the doctor away: Scurvy in the
Year 2000. Pediatrics: 2001: 108: 1-5.
Weinstein M, Cohen E, MacLean J: Antiplasmin
therapy for the treatment of
lymphangiectasia. Pediatrics: 2002: 109:
1177-1180.
Weinstein M, Friedman J: Clinician's Corner:
2 Cases. Paediatrics and Child Health:
2002: 7: 109-111.
books & book chapters
Krafchik BR: Atopic dermatitis. In:
Dermatology Textbook Online, Vol 2, No 8.
(Fritsch P, ed). Emedicine - Group
Publishing System - Dermatology Textbook
Online, http://www.emedicine.com: 2001.
Krafchik BR: Subcutaneous fat necrosis of the
newborn. In: Treatment of Skin Disease
(Lebwohl IM, Heymann WR, Berth-Jones J,
Coulson I., eds). Harcourt Health Sciences,
London, UK: 2002: 610-612.
research and investigations
A 6-month open label, multi-national,
effectiveness and safety study of
Elidel (pimecrolimus) cream 1% in
subjects with atopic dermatitis.
Krafchik BR: Novartis Pharmaceuticals
Canada Inc ($21,168 2002).
A multi-centre study, across Canada
- A prospective study on the age of
onset, incidence, geographic
distribution and risk factors
associated with atopic dermatitis
(Additional funding awarded 1998).
Krafchik BR, Pelletier J: Canadian Dermatology
Foundation ($35,000 1996 - 2002).
A multicentre, single arm prospective,
open label study to assess the
safety of Elidel (SDZ ASM 981 -
pimecrolimus) cream 1% in patients
with atopic dermatitis (Rainbow
study). Krafchik BR, Pope E: Novartis
Pharmaceuticals Canada Inc ($7,000 2002).
A population based cohort study of
incidence, health care utilization
and health outcomes in children
with stroke. deVeber G, To T: The Canadian
Institutes of Health Research ($99,576
2002 - 2004).
Accidental and Non-accidental
Paediatric Brain Injury. Multicenter
Study. Linda Ewing-Cobbs, Marsha Barnes,
Derek Armstrong, Suzanne Laughlin, Robin
Humphreys, Marcellina Mian: National Institute
of Health - Grant #2R01NS29462-05
($1,203,021 2000 - 2005).
An open-label study to evaluate
the safety of topically applied
tacrolimus ointment for the
treatment of atopic dermatitis (Pro-
004). BR Krafchik: Fujisawa Canada Inc
($22,000 2001 - 2002).
An open-label, long-term follow-up
study to evaluate the safety of
topically applied tacrolimus
ointment for the treatment of
atopic dermatitis in pediatric
patients (PRO - 002b). BR Krafchik:
Fujisawa Canada Inc ($30,000 2001).
Angiogenesis (bFGF, VEGF) and RAS
activation in neurofibromatosis
type 1 associated plexiform

neurofibroma. Baruchel S, Parkin P,
Gesundheit B, Becker L, Guha A: Hospital for
Sick Children Research Institute Seed
Grant ($35,850 2000 - 2002).
Bone mineral density after pediatric
liver transplantation. Ng V, Macarthur C,
Hawker G: Hospital for Sick Children
Foundation ($32,232 2001 - 2003).
Case verification for paediatric
asthma surveillance. To T, Cicutto L., Dell
S, Dick PT, MacLusky I: Health Canada
($30,000 2002 - 2003).
Characterizing episodes and
utilization of home care in
children. Dick PT, To T, Schachar R: The
Hospital for Sick Children Research
Institute, Seed Grant Competition
($31,500 2000 - 2001).
Child Health Services Research Group
Salary Support. To T, Dick PT: The Hospital
for Sick Children Research Institute and
Institute for Clinical Evaluative Sciences
(ICES) ($65,790 2002 - 2004).
Childhood Asthma Surveillance and
Measurement of Health Outcomes.
To T, Cicutto L: The Ontario Ministry of
Health and endorsed by Health Canada
($270,498 2001 - 2003).
Crash Protection for Children.
Howard A, Wright J, Parkin P, Letts R, Mackay M,
German A: Ontario Neurotrauma
Foundation ($231,639 2000 - 2003).
Creating the Healthcare
Professional: The role of situated
language practices in clinical
education settings. Schryer C, Lingard L,
Boyd M, Mian M: Social Sciences and
Humanities Research Council of Canada
($115,000 2000 - 2003).
Defining the genetic basis of atopic
dermatitis based on a reliable
phenotype. Krafchik BR, Albers S, Siminovitch
K: Pediatric Consultants Grant ($4,000
1997 - 2002).
Describing the health status of
Canadian children: Exploring the
Health Utilities Index Mark III
Measurement. Young N, To T: Institute for
Clinical Evaluative Sciences (ICES)
($14,000 2000 - 2001).
Determinants of regional variation
in Emergency Department utilization
and hospitalizations for asthma in
Ontario. Lougheed D, To T: National Health
Research and Development Program
(NHRDP) ($276,800 2000 - 2001).
Development of a workload
measurement tool for teaching and
educational endeavours of
pediatric faculty. Tallett SE, Hellmann J,
Hilliard RI, Jefferies AL, Leslie K, Lingard L, Pirie J,
Rosenfield J, Schneider R: Dean's Excellence
Fund ($4,105 2002 - 2003).
Do children with acute bronchiolitis
need chest radiographs? Schuh S, Dick
PT: The Physicians' Services Incorporated
Foundation ($66,521 2001 - 2003).
Effect of drug plans status, health
outcomes and health service use in
children with asthma. Ungar W, To T,
Reisman J, Gold M, Bikangaga P: The Medical
Research Council ($339,108 2000 - 2002).
Endowment fund from donor's
estate - Epidermolysis bullosa fund
for research and treatment of
patients with epidermolysis bullosa.
Krafchik BR: The Hospital for Sick Children
Foundation ($25,000 1994 - 2002).
Evaluation of Safe Kids Week 2000:
Scald and Burn Injury Prevention.
Macarthur C: Safe Kids Canada ($40,000
2001 - 2002).
Faculty development for community
pediatric teachers. Leslie K, Hilliard RI,
Schneider R, Tallett SE: Dean's Excellence
Fund for Undergraduate Medical
Education ($16,300 2002 - 2003).
Health, social and environmental
determinants for developmental
attainment in young children in
Canada. To T, Dick PT, Parkin P, Rosenfield J,
Guttmann A, Cadarette S: National Health
Research and Development Program
(NHRDP) ($54,200 2000 - 2001).
Integration of teletriage and
homecare services into a
sustainable service for Toronto
children. Dick PT, Young N: The Richard
Ivey Foundation ($250,000 2000 - 2003).
Investigator Award (Salary &
Benefits). To T: The Canadian Institutes
of Health Research & The Ontario
Ministry of Health and Long Term Care
($375,000 2001 - 2005).
Meta-analysis of community-based
injury prevention programs. Parkin P,
Macarthur C: The Hospital for Sick Children
Research Institute Seed Grant ($15,831
2001 - 2002).
Methylphenidate (Ritalin) use in
Canadian children. Charach A, To T,
Schachar R: Psychiatry Endowment Fun
($16,820 2000 - 2001).
Mortality and outcomes of
tetralogy of fallot in an adult
cohort. McCrindle B, Gatzoulis M, Webb G, To
T: Heart & Stroke Foundation of Canada
($290,718 1999 - 2002).
Ontario Ministry of Health Career
Scientist Award - Salary + Benefits.
Dick PT: Ontario Ministry of Health
($250,000 1999 - 2004).
Rapid detection of RSV from nasal
swabs. Ipp M, Petric M, Parkin PC: Becton &
Dickenson ($38,000 2001 - 2003).
Tacrolimus pharmacokinetics in
pediatric atopic dermatitis patients
after topical administration of
Protopic (tacrolimus) ointment
0.03%. Krafchik BR: Fujisawa Healthcare
Inc ($72,450 2001).
Technical skill in the paediatric
setting: A qualitative study of
acquisition, attitudes, and
assumptions. Lingard L, Bannister S, Regehr
G, Hilliard RI: Physicians' Services
Incorporated ($7,675 2002 - 2003).
The Paediatric Acute Asthma
Management Protocol (PAMP)
Project: Development, Implementation
and Outcomes. To T, Dell S, Fleming-Carroll
B, MacLusky I, Parkin P, Reisman J, Scolnik D,
Ungar W: The Ontario Ministry of Health
Drug Utilization Advisory Committee
($210,740 2002 - 2004).
The progression of parental
bereavement. Barrera M., D'Agostino N,
Nicholas D, Schneiderman G, Tallett S: The
Hospital for Sick Children Research Institute
47

2002 Seed Grant ($25,040 2002 - 2004).
Trainee Start-up Fund. The efficacy
of Zafirlukast in patients with
moderate to severe atopic
dermatitis. Pope, E: Research Institute,
The Hospital for Sick Children, Toronto,
Ontario ($2,000 2001).
Use of Amethocaine cream
(Ametop) for vaccination pain in
infants. Koren G, Taddio A, Ipp M, Goldbach M,
Koren G: Smith and Nephew, Montreal
($52,000 2001 - 2002).
Weston Grant for Pediatric
Dermatology for the study” The
efficacy and safety of intravenous
pulse steroids compared to
standard oral steroids in the
treatment of problematic
hemangiomas in infants: A
randomized controlled trial”. Pope E,
Krafchik B, Weinstein M: Society for Pediatric
Dermatology ($20,000 2002 - 2004).
48

faculty Dr. Allan L. Coates – Head, Dr. Sharon
Dell, Dr. Ian B. MacLusky, Dr. Hugh O’Brodovich,
Dr. Hiran Selvadurai – Scientist, Dr. Melinda
Solomon, Dr. Padmaja Subbarao, Dr. Neil Sweezey
part time Dr. Peter Bikangaga fellows
Dr. Ahmed Abu-Abah, Dr. Sherri Katz, Dr. Piush
Mandhane, Dr. Meir Mei-Zahav, Dr. Theo Moraes,
Dr. Vishwa Narayan, Dr. Mary Noseworthy,
Dr. Daniel Trachsel
The Respiratory Medicine
Programme provides comprehensive
care for the full range of paediatric
pulmonary disease. Overall clinical
responsibility is assumed for
children with complex asthma,
cystic fibrosis, interstitial lung
disease, and chronic respiratory
insufficiency in infancy due to
prematurity and/or congenital
malformations. We also provide
consultation support for the
Hospital in all areas of paediatric
respiratory disease. We maintain an
ongoing follow-up programme for
children with chronic respiratory
insufficiency, and who are
technologically dependent. The
Sleep Laboratory (the only
dedicated paediatric sleep
laboratory in Ontario) provides
ongoing follow-up in care for
children with sleep apnea, sleep
related respiratory insufficiency, as
well as being affiliated with
Divisions of Neurology and General
Paediatrics in caring for children
with complex neuro-behavioural
sleep disorders. The Division is part
of the Toronto Lung
Transplantation Programme,
providing pre- and post
transplantation care for children
with end-stage lung disease. The
Division also provides a flexible
bronchoscopy programme in the
diagnosis of children with
Division of RESPIRATORY MEDICINE
interstitial lung disease, anatomical
abnormalities and infections in the
immunocompromised host.
The training programme has
independent Royal College of
Physicians and Surgeons of Canada
accreditation and provides the full
range of training that is required for
Board Certification in Pediatric
Pulmonology in the United States.
As well as offering training to Royal
College of Physicians and Surgeons
of Canada eligible candidates, it also
trains physicians from abroad.
The major research foci include
clinical and basic science studies in
aerosol therapy and exercise physiology,
asthma, the molecular biology of
electrolyte transport in the lung
epithelium, novel genes in lung
development and the NIH Childhood
Asthma Management Programme
Continuation Study as well as a
number of smaller clinical studies.
publications
Coates AL: What is the cystic fibrosis
clinician supposed to do with human
recombinant dornase alfa? Journal of
Pediatrics: 2001: 139: 768-770.
Coates AL: The special challenges of
aerosolization of medication to
technologically-dependent children.
Pediatric Pulmonology: 2001: 32: 129-131.
Hancock TJ, Subbarao P, Kamada D, Watson
RM, Hargreave FE, Inman MD: Beta2-
Agonist Tolerance and Exercise-Induced
Bronchoconstriction. American Journal of
Respiratory and Critical Care Medicine:
2002: 165: 1068-1070.
Ho SL, Kwong WTJ, O'Drowsky L, Coates AL:
Evaluation of four breath-enhanced
nebulizers for home use. Journal of Aerosol
Medicine: 2001: 14: 467-475.
O'Brodovich H: Career development and
compensation:Strategies for Physicians in
Academic Health Science Centers. Journal
of Pediatrics: 2001:139:171-172.
O'Brodovich H: Pulmonary Edema Fluid
Movement within the Lung. (Editorial).
Am. J. Physiol. (Lung, Cellular and
Molecular Physiology): 2001: 25: L1324 -
L1325.
O'Brodovich, Hugh: Fetal Lung Liquid
Secretion: Insights using the tools of
Inhibitors and Genetic Knock-out
Experiments. American Journal of
Respiratory Cell and Molecular Biology:
2001: 25: 8-10.
Otulakowski G, Freywald T, Wen Y, O'Brodovich
H: Translational activation and repression
by distinct elements within the 5'-UTR of
ENaC Alpha-subunit mRNA. American
Journal of Physiology, Lung Cell Molecular
Physiology: 2001: 281: L1219-1231.
Dell S, Parkin PC, McArthur C: Asthma
hospitalizations: determinants of short stay.
Journal of Pediatric Allergy and
Immunology: 2001:12:327-330.
Schuh S, Coates AL, Binnie R, Allin T, Goia
C, Corey M, Dick PT: Efficacy of oral
dexamethasone in outpatients with acute
bronchiolitis. Journal of Pediatrics: 2002:
1: 27-32.
Selvadurai HC, Van Asperen PP, Mellis CM,
Cooper PC, Blimkie CJ: The relationship
between genotype and fitness in children
with Cystic Fibrosis. American Journal of
Respiratory and Critical Care Medicine:
2002:165:762-765.
Selvadurai HC, van Asperen PP, Mellis CM,
Cooper PJ, Blimkie CJ: A randomised
controlled study of in hospital exercise
training programs in children with Cystic
Fibrosis. Pediatric Pulmonology: 2002:33:
194-200.
Sharon Dell, Teresa To: Breastfeeding and
asthma in young children: Findings from a
population-based study. Archives of
Pediatrics and Adolescent Medicine: 2001:
155: 1261-1265.
Young NL, Foster RN, Parkin PC, Reisman J,
MacLusky IB, Gold M, Feldman W:
Assessing the efficiency of a school based
asthma education program for children: A
pilot study. Canadian Journal of Public
Health: 2001: 92: 30-34.
books & book chapters
O'Brodovich H: Disorders of ion transport.
In: The Basic Mechanisms of Pediatric
Respiratory Disease: 2nd Edition (Haddad
G, Abman S, Chernick V, eds). B.C. Dekker,
Hamilton and London: 2002: 294-311.
research and investigations
Aerosol Laboratory Support. Coates
Al: Research Institute, Hospital for Sick
Children ($35,000 2001 - 2002).
CAMP-CS: The Hospital for Sick
Children Clinical Centre for Study of
a Childhood Asthma Management
Program - Continuation Study.
MacLusk I, John Hopkins University Centre for
49

Clincal Trials: National Institutes of Health National Heart, Lung
and Blood Institute ($2,000,000 1999 - 2003).
Can cardiopulmonary exercise testing with impedance
cardiography identify optimal interventions in children
with congenital heart disease? Coates AL: Research Institute,
HSC - ($35,605 2000 - 2002).
Case Verification For Paediatric Asthma Surveillance.
Teresa To, S. Dell, P. Dick, L. Cicutto, I. MacLusky: Ontario Ministry of
Health and Long-Term Care ($30,000 2001 - 2002).
Case Verification For Paediatric Asthma Surveillance.
Teresa To, S. Dell, P. Dick, L. Cicutto, I. MacLusky: The Hospital for Sick
Children Asthma Seed Grant ($7,000 2001 - 2002).
Does physical activity make a difference to lung health
in cystic fibrosis? Coates AL: Canadian Cystic Fibrosis
Foundation ($149,743 2000 - 2003).
Effect of heparin derivatives on thrombin regulation
by the fetal lung surface. Chan A, O'Brodovich H, Andrew M:
Medical Research Council of Canada ($93,000 1999 - 2002).
Fetal response to maternal exercise in women with
uteroplacental insufficiency. Simchen M, Hornberger L, Kingdom J,
Allen V, Coates A, Smallhorn J: Physician's Services Incorporation
Foundation ($120,660 2001 - 2003).
Functional analyses of two novel developmentally
regulated genes in fetal lung. Kaplan F, Sweezey NB: Canadian
Institutes of Health Research (formerly MRC Canada) ($342,414
2000 - 2003).
Gender hormone modulation of the CF lung
phenotype. Sweezey NB: Canadian Cystic Fibrosis Foundation
($215,700 2000 - 2003).
Glucocorticoid receptor and glucocorticoid-responsive
genes in developing lung. Sweezey NB, Kaplan F, Genetics, McGill
University: Canadian Institutes of Health Research (formerly MRC
Canada) ($273,540 2000 - 2003).
NA4448 Pulmonary edema's effect on epithelial ion
and fluid transport. O'Brodovich H: Canadian Heart Foundation
(Heart and Stroke Foundation of Ontario) ($159,920 2000 - 2002).
Regulation of lung epithelial Na channel expression.
O'Brodovich H, Otulakowski G (Co-P.I.): Medical Research Council of
Canada ($86,295 1999 - 2004).
Sodium channel expression in the developing human
lung. O'Brodovich H, Otulakowski G (Co-P.I.): Canadian Lung
Association (Ontario Thoracic Society) ($34,000 2000 - 2002).
Training Program in Clinical Nutrition. Pencharz PB, Anderson
GH, Coates AL, Cole DEC, Darling P, Jenkins DJA, O'Connor D, Tamsuk VS,
Wolever T, Zlotkin S, Archer MC, Berall G, Cunnane S, Thompson LU, Kidd B,
Goode RC, Goodman JM: Canadian Institute for Health Research
($1,590,000 2002 - 2008).
50

faculty Rayfel Schneider – Chief, Brian Feldman, Ronald Laxer,
Earl Silverman, Rae Yeung part time Bonnie Cameron, Lynn Spiegel
cross appointment Michael Dosch residents Susanne Benseler,
Christina Boros, Claire LeBlanc, Deborah Levy, Athimalaipet Ramanan,
Abdullah Al Sonbul research fellow Shirley Tse
The Division of Rheumatology has had a significant
increase in the number of patients attending clinics.
One half-day new consult clinic was recently added to
accommodate the increased numbers of referrals and
the number of general rheumatology follow-up clinics
were increased by two half-day clinics per month.
Dr. Ron Laxer received the prestigious Council Award of
the College of Physicians and Surgeons of Ontario in
recognition of his qualities that meet society's
expectations of an “ideal physician”.
Ms. Elizabeth Morais, Rheumatology Information
Co-ordinator, received the Dr. Robert Salter
Humanitarian Award for her demonstration of
compassion and humanitarianism with children,
parents and colleagues at HSC.
This year two practitioners graduated from the Division
of Rheumatology PT/OT Practitioner Program at HSC, as
well as an OT Practitioner who will return to work in
the Sudbury Outreach Clinic.
The Division of Rheumatology held it's first Juvenile
Arthritis Education Day for parents and children at The
Hospital for Sick Children. The event was extremely well
attended and included talks and workshops that
provided lively discussion and received positive
feedback from all who attended.
Dr. Brian Feldman was awarded a Tier II, Canada
Research Chair in Childhood Arthritis in February 2002.
At the American College of Rheumatology Meeting in
November 2001, Dr. Deborah Levy, Rheumatology Fellow,
won the Paediatric Rheumatology Research Award for
her abstract entitled “Giant aneurysms in Kawasaki
disease: Is natural history affected by anticoagulation?”.
She also won the American Academy of Pediatrics
Section of Rheumatology, Earl J. Brewer Travel Grant for
her podium presentation on “Thromboembolism in
pediatric systemic lupus erythematosus (SLE) patients
with antiphospholipid antibodies.
52
Division of RHEUMATOLOGY
Dr. Shirley Tse, Rheumatology Research Fellow, received
the Canadian Rheumatology Association Best Basic
Science Presentation Award. She also placed second at
The Hospital for Sick Children and Department of
Paediatrics, University of Toronto Annual Resident
Research Day for her presentation entitled: “Persistence
of chlamydia in reactive arthritis: via host lipid trafficking?”
Dr. Alvin Loh, Paediatric Resident, received second place
in the Core Paediatric Division at The Hospital for Sick
Children and Department of Paediatrics, University of
Toronto Annual Resident Research Day for his presentation
entitled: “Quality of life disability and pain in children
with nonarticular rheumatism compared to children
with other chronic rheumatological pain disorders.”
publications
Ayling-Campos A, Graveline C, Ferguson J, Lundon K, Feldman B,
Schneider R and Laxer R: The Physical Therapy Practitioner (PTP) in
Pediatric Rheumatology: Parents Satisfaction Survey Physiotherapy
Canada: 2002: 54: 32-36.
Ayling-Campos A, Graveline C, Ferguson JM, Lundon K, Schneider R,
Laxer RM: The physical therapy practitioner: An expanded role for
physical therapy in pediatric rheumatology. Physiotherapy Canada:
2001: Fall: 282-287.
Barron, KS, Wallace C, Woolfrey A, Laxer RM, Hirsch R, Horwitz M,
Siegel J, Filipovich L, Wullffraat N, Passo M, Rider LG: Autologous
stem cell transplantation for pediatric rheumatic diseases. Journal of
Rheumatology: 2001: 28: 2337-2358.
Brunner HI, Chan W-S, Ginsberg JS, Feldman BM: Long-term
anticoagulation is preferable for patients with Antiphospholipid
Antibody Syndrome. Result of a decision analysis. Journal of
Rheumatology: 2002: 29: 490-501.
Brunner HI, Silverman ED, To T, Bombardier C, Feldman BM: Risk
Factors for Damage in Childhood-Onset Systemic Lupus Erythematosus:
Cumulative Disease Activity and Medication Use Predicts Disease
Damage. Arthritis and Rheumatism: 2002: 46: 436-444.
Campos AA, Graveline C, Ferguson JM, Lundon K, Feldman BM,
Schneider R, Laxer RM: The Physical Therapy Practitioner (PTP) in
Pediatric Rheumatology: High level of patient and parent
satisfaction with services provided by the PTP. Physiotherapy
Canada: 2002: Winter: 32-36.
Dempster H, Porepa M, Young N, Feldman BM: The clinical meaning
of functional outcome scores in children with juvenile arthritis.
Arthritis and Rheumatism: 2001: 44: 1768-1774.
Gladman G, Silverman ED, Yuk-Law, Luy L, Boutin C, Laskin C,
Smallhorn JF: Fetal Echocardiographic Screening of pregnancies of
Mothers with Anti-Ro and/or Anti-La Antibodies. American Journal
of Perinatology: 2002: 19: 73-80.
Honkanen VEA, Siegel AF, Szalai JP, Berger V, Feldman BM, Siegel JN: A
three-phase clinical trial design for rare disorders. Statistics in
Medicine: 2001: 20: 3009-3021.
Jaeggi ET, Hamilton RM, Silverman ED, Zamora SA, Hornberger LK:
Outcome of children with fetal, neonatal or childhood diagnosis of
isolated congenital atrioventricular block A single institution's
experience of 30 years. Journal of the American College of
Cardiology: 2002: 39: 130-137.
Laxer RM, Harrison C: Bioethical issues in autologous stem cell
transplantation in children and adults with arthritis. Journal of
Rheumatology: 2001:28:2147-2150.

Miller FW, Rider LG, Chung Y-L, Cooper R,
Danko K, Farewell V, Lundberg I, Morrison
C, Oakley L, Oakley I, Pilkington C,
Vencovsky J, Vincent K, Scott DL, Isenberg
DA for the International Myositis Outcome
Assessment Collaborative Study Group:
Proposed preliminary core set measures for
the disease outcome assessment in adult
and juvenile idiopathic inflammatory
myopathies. Rheumatology: 2001: 40:
1262-1273.
Muzaffer M, Dayer JM, Feldman BM,
Pruzanski W, Roux-Lombard P, Schneider R,
Laxer RM, Silverman ED: Differences in the
profiles of circulating levels of soluble
tumour necrosis factor receptors and
interleukin-1 receptor antagonist reflect the
heterogeneity of the subgroups of juvenile
rheumatoid arthritis. Journal of
Rheumatology: 2002: 29: 1071-1078.
Nield, LE, Silverman ED, Taylor GP,
Smallhorn JF, Mullen JBM, Silverman NH,
Finley JP, Law YM, Human DG, Seaward
PG, Hamilton RM, Hornberger LK:
Maternal Anti-Ro and Anti-La Antibody
Induced Endocardial Fibroelastosis.
Circulation: 2002: 105: 843-848.
Tune, C., Martin, A., and Dosch, H.-M.
Sustained expression of the novel EBVinduced
zinc finger gene, ZNFEB, is critical
for the transition of B lymphocyte
activation to oncogenic growth
transformation. Journal of Immunology:
2001: 168:680-688.
Tse SML, Silverman ED, McCrindle BW,
Yeung RSM: Early treatment with
intravenous immunoglobulin in patients
with Kawasaki disease. Journal of Pediatrics:
2002: 140: 450-455.
Winer, S., Astsatourov, I., Cheung, R.K.,
Gunaratnam, L., Kubiak, V., Cortez, M.A.,
Moscarello, M., O’Connor, P.W., McKerlie,
C., Becker, D.J., and Dosch, H.-M. Type 1
Diabetes and Multiple Sclerosis patients
target islet plus nervous system
autoantigens; nonimmunized nonobese
diabetes mice can develop autoimmune
encephalits. Journal of Immunology: 2001:
166:2831-2841.
Winer, S., Astsatourov, A., Cheung, R.K.,
Schrade, K., Gunaratnam, L., Wood, D.D.,
Moscarello, M.A., O'Connor, P., McKerlie,
C., Becker, D.J., and Dosch, H.-M. T Cells of
MS patients target a common
environmental peptide that causes
encephalitis in mice. Journal of
Immunology: 2001: 166:4751-4756.
Winer, S., Astsaturov, I., Cheung, R., Tsui, H.,
Song, A., Gaedigk, R., Winer, D., Sampson,
A., McKerlie, C., Bookman, A., and Dosch,
H.-M. Prevention of Primary Sjøgren's by
ICA69-deficiency. Lancet: 2002: 360:1063-
1069.
Winer, S., Gaedigk, R., Astsaturov, I.,
Hammond-McKibben, D., Pilon, M., Song,
A., Kubiak, V., Karges, W., Arpaia, E.,
McKerlie, C., Zucker, P., Singh, B., and
Dosch, H.-M. ICA69null NOD mice develop
diabetes but resist disease acceleration by
cyclophosphamide. Journal of
Immunology: 2002: 168:475-482.
research and investigations
A proteomics approach to the
staging of autoimmune diabetes
and multiple sclerosis. H.-M. Dosch (PI):
Syn•X Pharma Inc. ($144,162./yr 2000-
2002)
A randomized clinical trial to
compare intermitten therapy to
escalating dose prophylaxis with
recombinant Factor IX (Benefix) in
hemophilia B. Feldman BM: Wyeth/Genetics
Institute ($5,000 2001 - 2002).
A randomized, double-blind trial of
anti-TNF alpha chimeric monoclonal
antibody (Infliximab) in
combination with methotrexate for
the treatment of patients with
polyarticular juvenile rheumatoid
arthritis. Silverman ED (PI), Feldman B, Laxer
R, Spiegel L: Centocor ($10,408 US 2002-
2003)
A safety and efficacy study of
Etanercept in children with
systemic onset juvenile rheumatoid
arthritis. Schneider R (PI), Silverman ED (Co-
PI): Amgen ($67,000 US 2002-2003).
A serial N-of-1 trials comparison of
ondansetron plus metopimazine
versus ondansetron alone in
children with malignant brain
tumours receiving highly
emetogenic therapy. Feldman BM,
Nathan P: Resident's Research Study
Physicians Services Incorporated ($17,750
2001 - 2002).
A serial N-of-1 trials comparison of
ondansetron plus metopimazine
versus ondansetron alone in
children with malignant brain
tumours receiving highly
emetogenic therapy. Feldman BM,
Nathan P: The Hospital for Sick Children
Research Institute Seed Grant ($10,215
2002 - 2003).
Canada Research Chair Tier II.
Feldman BM: Canadian Institutes of Health
Research ($500,000 2002 - 2007).
Career Scientist. Feldman BM: Ontario
Ministry of Health ($250,000 1996 - 2001).
Characterization of GFAPautoimmunity
in human and rodent
Type 1 diabetes. H.-M. Dosch (PI): Syn•X
Pharma Inc.-CIHR/U-I ($111,511/yr 2002-
2004).
Characterization of ICA69, a major
new beta-cell protein with
unknown function. H.-M. Dosch (PI):
Canadian Institutes of Health Research
($56,304/yr 1999-2002)
Comparison of amitriptytline and
placebo for the reduction of pain
in children with polyarticular
juvenile rheumatoid arthritis using
serial n-of-1 trials to estimate
population effect. Feldman BM, Huber A,
Koren G, Szalai JP: Medical Research Council
($32,760 2000 - 2002).
Cost-effectiveness of escalating
frequency factor VIII prophylaxis in
severe hemophilia A. Feldman BM,
Blanchette V, Einarson T, Rivard G, Israels S,
Robinson S, Oh P, Babyn P, Hedden D:
MRC/PMAC Health Program ($375,000
1999 - 2002).
Development of an activity
measure for SoJRA. Feldman BM,
Ramanan AV, Schneider R: Pfizer Inc.
($160,000 2001 - 2002).
Development of NOD mouse
embryonal stem cell: A resource
development program. H.-M. Dosch (PI):
Juvenile Diabetes Foundation Int’l U.S
($140,250/yr US 2001-2003)
Differential proteomics of preclinical
autoimmunity. H.-M. Dosch (PI):
CIHR/University Industry $101,175/yr
2002-2004).
Efficacy and safety of leflunomide
versus methotrexate in the
treatment of pediatric patients
with juvenile rheumatoid arthritis.
Spiegel L (PI), Feldman B, Laxer R: Aventis
($33,970/yr 2002-2003).
Impact of intracranial bleeds on the
health and quality of life of boys
with hemophilia. Feldman BM, Blanchette
V, McNeely M, Barnes M, Logan W: Aventis
Behring Canada Research Fund ($29,788
2001 - 2002).
53

Kawasaki Disease: How a mouse
becomes the vehicle of choice for
studying coronary arthritis. Yeung
RSM, Silverman ED (Co-Investigator): Heart and
Stroke Foundation ($207,088 2000 - 2002).
Kawasaki Disease: On our way to
unraveling the pathogenesis. Yeung R
(PI), Silverman ED (Co-PI): Canadian Institute
for Health Research. ($129,000/yr 2002 -
2005).
Maternal autoantibodies in pregnancy
and congenital atrioventricular
block. Silverman ED, Hornberger L (Co-PI):
March of Dimes Birth Defects Foundation
($295,852 2000 - 2003).
Molecular mechanisms in diabetic
autoimmunity. H.-M. Dosch (PI): CIHR
($168,139/yr 2001-2006).
Multi-disciplinary research program
in cardiovascular disease and
development. Group Leader: Marlene
Rabinovitch, Group Members: Bruneau B, Hinek A,
Hussein M, Keeley F, Silverman E, Wilson G, Yeung
R: Canadian Institutes for Health
Research Group Grant ($230,000/yr 2001-
2005)
Multi-User Equipment Grant.
Shared Flow Cytometry Facility. PI:
Guidos C, Co-investigators: Danska J, Yeung R,
Dick J, Chamberlain J, Hitzler H: Canadian
Institutes for Health Research ($51,000/yr
2001–2006)
54
New Investigator Award. Dr. Rae Yeung:
The Arthritis Society of Canada/Canadian
Institute of Health Research ($50,000/yr
2001-2006).
Nutritional primary prevention of
Type I diabetes in children. H.K.
Åkerblom (PI), H.M. Dosch (Co-PI) (TRIGR – Multinational
Clinical Trial): National Institutes of
Health (U.S.) $1,830,000/yr US 2001-
2006).
Open-label extension treatment
with TNFR:Fc participating patients
in TNFR:Fc clinical trials. Schneider R
(PI), Feldman B, Laxer R, Silverman ED, Spiegel L:
Amgen ($5,000/yr 1998 – 2003).
Pediatric systemic lupus
erythematosus clinic operating
grant. Silverman ED: Arthritis Society of
Canada ($225,000 1987 - 2002).
Phase II, multiple dose treatment
of Type I diabetes with hOKT3
gamma-1 (Ala-Ala). Immune
Tolerance Network (ITN) Clinical
Trial. Dosch: ITN T Cell comparative
WS K. Harold, PI, H.-M. Dosch, Site Investigator:
National Institutes of Health (U.S.)
($765,579/yr US, Dosch: $70,000/yr US)
2002-2005)
The Genetics of Childhood-Onset
SLE. Chaim Jacob (PI), Earl Silverman: National
Institutes of Health ($256,786 1998 -
2003).
The role of superantigens in
autoimmunity. Yeung R (PI): The Arthritis
Society of Canada ($75,000/yr 2001-2003)
Towards a Type 1 diabetes vaccine.
H.-M. Dosch (PI): CIHR-Proof of Principle
($100,000/yr 2002-2003).
Trial to reduce IDDM in Type I
diabetes in the genetically at risk. J.
Dupré (PI), H.-M. Dosch (National Clinical Trial)
(TRIGR), M. Lawson, W. Fraser: CIHR
($1,772,236/yr 2001-2011).
Validity of a modified standard
gamble technique to measure
quality of life in children with
significant medical conditions.
Feldman BM, Sung L, Ingber S, Rubenstein J,
McLimont M, Young N, Blanchette V, Greenberg
M, Doyle JJ: Paediatric Consultants ($4,988
2001 - 2002).

Dr. Lorelei Lingard - Assistant Professor,
Department of Paediatrics and Faculty of Medicine
Centre for Research in Education, University
of Toronto
publications
(PA=Principal Author; SA=Senior Author; CoPA= Co-principal author;
C=Collaborator). Each publication is identified as Research ® or
Education (E).
Espin S, Lingard L (SA). “Nurse-Surgeon Communication in the
Operating Room: ‘Time’ as a Catalyst for Tension.” The Association
of Operating Room Nurses Journal. November 2001 Vol. 74: 5, 672-
82. ®
Ginsburg S, Regehr G, Stern D, Lingard L (SA). “The Anatomy of the
Professional Lapse: Bridging the Gap Between Traditional
Frameworks and Students’ Perceptions.” Academic Medicine. June
2002 Vol. 77: 6: 516-22. ®
Haber R, Lingard L (CoPA). “Learning Oral Presentation Skills: A
Rhetorical Analysis with Pedagogical and Professional Implications.”
The Journal of General Internal Medicine. May 2001 Vol. 16: 5, 308-
314. ®
Lingard L (PA), Garwood K, Szauter K, Stern D. “The Rhetoric of
Rationalization: How Students Grapple with Professional
Dilemmas.” Academic Medicine. October 2001 Vol 76:10
(Supplement): 45 - 47. ®
Lingard L (PA), Haber RJ. “Learning Medical Talk: How the
Apprenticeship Complicates Current Explicit/Tact Debates in Genre
Instruction.” In Coe, Lingard, Teslenko, eds. The Rhetoric and
Ideology of Genre. Cresskill, NJ: Hampton Press, 2002. ®
Lingard L (PA), Reznick R, Espin S, DeVito I, Regehr G. “Team
Communications in the Operating Room: Talk Patterns, Sites of
Tension & Implications for Novices.” Academic Medicine. March
2002 Vol. 77: 3: 37-42. ®
research and investigations
Eva K, Lingard L (CoPI), Walsh A, Neville A. “The Role of Clinical
Relevance in Memory Tasks.” Royal College of Physicians
and Surgeons of Canada ($19,520 2002)
Ginsburg S, Regehr G, Lingard L (SI). “Through Evaluators’ Eyes:
Attending Physicians’ Perceptions of Professionalism in
Medical Students.” Medical Council of Canada ($24,245
2002-2003)
Ginsburg S, Regehr G, Stern D, Lingard L (CoI). “Evaluating
Professionalism through the Examination of
Behaviours.” Medical Council of Canada ($25,000 2000-2001)
Hawryluck L, Lingard L (CoPI). “Team Communication,
Collaboration and Education in the Intensive Care Unit:
A Qualitative Analysis.” University of Toronto Faculty of
Medicine Dean’s Fund ($10,000 2001-2002)
Kennedy TJ, Leslie K, Rosenfield J, Lingard L (SI). “Oh no, not her
again”: Constructions of the ‘difficult’ patient in
paediatric medical education.” CIHR/Association of
Canadian Medical Colleges ($19, 916.80 2002-2003).
56
Inter-Divisional COLLEAGUES
Kennedy T, Lingard L (SI), Rosenfield J, Regehr G, Roberts W. “Exploring
the Gap Between Knowledge and Behaviour: A
Qualitative Study of Clinician Action Following An
Educational Intervention.” Canadian Institutes for Health
Research/Association of Canadian Medical Colleges ($19,492
2001-2002) and Physician Services Incorporated Foundation.
($7,292 2001-2002)
Kushniruk A, Lingard L (CoPI) , Reznick R, Smith C. “Making Medical
Meaning: Cognitive, Social and Educational
Implications of the Computerized Patient Record.”
Social Sciences and Humanities Research Council of Canada
($139,000 2002-2005)
Lingard L, Bohnen J, Regehr G, Baker R, Orser B, Doran D, Reznick R, Grober
E. “Team Talk: An Intervention to Structure Information
Sharing and Promote Patient Safety in the Operating
Room.” Physician Services Incorporated Foundation ($25,000
2002-2003)
Lingard L (PI), Poenaru D. “Team Communications in the
Operating Room: What Role Does Institutional Context
Play?” Physician Services Incorporated Foundation ($42,481
2001-2002)
Lingard L (PI), Regehr G, Baker R, Orser B, Doran D, Reznick R, Bohnen J,
Grober E. “Team Talk: An Intervention to Structure
Information Sharing and Promote Patient Safety in the
Operating Room.” Canadian Institutes of Health
Research.($129,497 2002-2004)
Lingard L (PI), Szauter K, Stern D. “Negotiating Professional
Dilemmas: A Rhetorical Analysis of Reasoning and
Rationalization.” The Lyle Roll Fund for the study of Humane
Medicine at the University of Michigan ($11,630 2000-2001)
Musselman L, MacRae H, Reznick R, Lingard L (SI). “Intimidation and
Harassment and the Surgical Environment: What Is It
and What Does It Do to the Educational Environment?”
Physician Services Incorporated Foundation ($15,000 2002-2003)
and CIHR/Association of Canadian Medical Colleges ($2200
2002-2003)
Schryer C, Lingard L (CoPI), Spafford M, Boyd M “Creating the
Healthcare Professional: The Role of Situated
Language Practices in Clinical Education Settings.”
Social Sciences and Humanities Research Council of Canada
($115,000 2000-2003).
Stern D, Ginsburg S, Regehr G, Lingard L (CoI), Hodges B, McNaughton N,
Hatala R, Gruppen L, Grum C. “Professionalism Research:
Assessing Choices by Trainees in Clinical Education.”
The Gold Foundation for Humanism in Medicine ($10,000 US
2000-2001)

chief residents:
Carolyn Beck MD, Queen’s University
Ben Sivarajan MD, University of Toronto
associate chief residents:
Marilyn Abraham MD, University of Toronto
Brian Hershenfield MD, McGill University
Elizabeth Jimenez MD, University of Toronto
Jill Solomon MD, McGill University
Valerie Waters MD, McGill University
postgraduate year 4
Antonella Morra MD, American University of the
Caribbean, Montserrat
Tommy Ho MD, Queen’s University
postgraduate year 3
Nessa Bayer MD, University of Toronto
Tiscar Cavalle-Garrido MD, University of Valencia, Spain
Adam Cheng MD, University of Toronto
Melanie Henderson MD, McGill University
Lani Lieberman MD, University of Toronto
Aviva Lowe MD, McGill University
Shannon McPhee MD, Dalhousie University
Chelsea Ruth MD, University of Manitoba
Abdullah Shamsah MB,BCh, National University
of Ireland
Trenna Sutcliffe MD, McMaster University
Leah Tattum MD, Northwestern University, Chicago
Carolyn Taylor MD, University of Toronto
Brent Williams MD, Dalhousie University
2001-2002 Paediatric HOUSESTAFF
postgraduate year 2
Alexandra Ahmet MD, McMaster University
Khalid Al-Ansari MB.BS, King Faisal University
Zaid Al-Harbash MB.BS, Kuwait University
Sarah Barker MD, University of Ottawa
Eyal Cohen MD, University of Toronto
Tamar Flanders MD, McGill University
Deborah Fruitman MD, Dalhousie University
Steven Greenway MD, University of Manitoba
Ra Kyung Han MD, University of Toronto
Anita Jethwa MD, University of Toronto
Daphne Korczak MD, Queen’s University
Alvin Loh MD, University of Toronto
Joanna MacLean MD, McMaster University
Saba Merchant MB.BS, Amravati University, India
David Skidmore MD, University of Western Ontario
postgraduate year 1
Hosanna Au MD, University of Toronto
Chantelle Barnard MD, University of Saskatchewan
Matthew Crystal MD, University of Western Ontario
Tara Gelman MD, University of Toronto
Jane Healey MD, University of Toronto
Joanna Holland MD, University of Toronto
Ronik Kanani MD, University of Calgary
Susan Koshy MD, University of British Columbia
Alex Muise MD, University of Toronto
Angela Orsino MD, University of Toronto
Anwar Sallam MB BCh, Royal College of Surgeons, Ireland
Peggy Wong MD, University of Toronto
57

teaching awards
Harry Bain Award to a full-time member of the
Department of Paediatrics who demonstrates excellence
in teaching as nominated by core paediatric residents.
Dr. Jeremy Friedman, Paediatric Medicine
Marvin Gerstein Award to a part-time member of the
Department of Paediatrics who demonstrates excellence
in teaching as nominated by core paediatric residents.
Dr. Michael Peer, Paediatric Medicine
Ondaatje Award to a senior resident for excellence in clinical
teaching as nominated by core paediatric residents.
Dr. Ben Sivarajan, PGY4, Chief Resident
Dr. Adam Cheng, PGY3
PeRLS Awards (Paediatric Educational Resident Lecture
Series Award) to the faculty members who have
demonstrated commitment to excellence in teaching at
the Paediatric academic sessions.
Dr. Bairbre Connolly, Diagnostic Imaging
Subspecialty Teaching Award to the faculty member
who has demonstrated commitment to excellence in
teaching the subspecialty residents and clinical fellows.
Dr. Ian MacLusky, Respiratory Medicine
R.H.A Haslam Preclerkship Teaching Award to the
faculty member who has demonstrated excellence in
preclerkship teaching.
Dr. Denis Geary, Nephrology
Clerkship Teaching Award to the faculty member who
has demonstrated excellence in clerkship teaching.
Dr. Tara Baron, Paediatric Medicine
CME Award to the faculty member who has
demonstrated excellence in course coordination or
teaching in a Department of Paediatrics or University of
Toronto Continuing Education sponsored event.
Dr. Jonathan Hellman, Continuing Medical Education –
For coordination of the Paediatric Update Conference in 2001/2002
58
2001-02 AWARDS
clinical awards
Richard Rowe Award for Clinical Excellence in Paediatric
Medical Care to the physician in the Department of
Paediatrics who has demonstrated excellence in the
delivery of clinical care in its broadest sense over a
significant period of time.
Dr. Denis Geary, Nephrology
Award for Clinical Excellence in Paediatric Medical Care
to a physician within the first 5-10 years of
appointment to an Academic Health Science Centre,
who has demonstrated excellence in the delivery of
clinical care.
Dr. Brenda Banwell, Neurology
The Saunders Prize to a senior resident who has
demonstrated excellence in clinical paediatrics.
Dr. Tiscar Cavalle-Garrido, PGY3
research awards
Paediatric Research Awards for excellence in
resident research.
Core Paediatrics
Dr. Eyal Cohen, First Place
Dr. Alvin Loh, Second Place
Dr. Brent Williams, Poster Prize
Subspecialty Paediatrics
Dr. Hien Huynh, Gastroenterology/Nutrition
First Place - Basic Science
Dr. Shirley Tse, Rheumatology
Second Place – Basic Science
Dr. Astrid Guttmann, Paediatric Medicine
First Place – Clinical Research
Dr. Sherri Katz, Respiratory Medicine
Second Place – Clinical Research
Dr. Cecil Hahn, Neurology
First Place Poster
Dr. Michael Salman, Neurology
Honourable Mention – Poster

divisional

promoted to professor of paediatrics
Dr. Lee Ford-Jones:
Division of Infectious Diseases
Clinician-Teacher
Dr. Anne Marie Griffiths:
Division of GI/Nutrition
Clinician-Teacher
Dr. Brian McCrindle: Division of Cardiology
Clinician Scientist - Associate Scientist HSC-RI
Cross Appointment - Health Policy Management and Evaluation
Dr. Marcellina Mian:
Division of Paediatric Medicine
Clinician-Educator
Cross Appointment - Public Health Sciences
Dr. Suzanne Schuh:
Division of Emergency Medicine
Clinician-Investigator
Associate Scientist HSC-RI
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2001-2002 List of PROMOTIONS
promoted to associate professor of paediatrics
Dr. Gabrielle deVeber:
Division of Neurology
Clinician Scientist - Scientist HSC-RI
Dr. John Doyle:
Division of Haematology/Oncology
Clinician-Teacher
Dr. Elizabeth Harvey:
Division of Nephrology
Clinician-Teacher
Dr. Diane Hébert:
Division of Nephrology
Clinician-Teacher
Dr. Lisa Hornberger:
Division of Cardiology
Clinician-Scientist - Scientist Track HSC-RI
Dr. Aideen Moore:
Division of Neonatology
Clinician-Teacher
Dr. Ikuko Teshima:
Medical Genetics & Microbiology and Laboratory Medicine
and Pathobiology
Department of Paediatric Laboratory Medicine

For more details on 2001–2002, check our Web site:
A health care, teaching and research centre dedicated
exclusively to children; affiliated with the University of Toronto
*
University of Toronto The Hospital for Sick Children
555 University Avenue Toronto Ontario M5G 1X8 Canada tel: 416-813-1500
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