Annual Report 2001 - The Hospital for Sick Children

faculty O. Carter Snead III-Head, Brenda Banwell, Gabrielle deVeber, Robert
Haslam, William Logan, Daune MacGregor, Berge Minassian, Hiroshi Otsubo,
Wendy Roberts, Jay Rosenfield, Ingrid Tein, Jiri Vajsar, Shelly Weiss part-time
David Berbrayer, Joseph Bruni, Pam Cooper, Rosalind Curtis, Darcy Fehlings,
Cynthia Goldfarb, Karen Harman, Tammy Kagan-Kushnir, SML Kirkpatrick,
Jeffrey Kobayashi, John Lovering, Douglas McGreal, Gilbert Miller, Golda
Milo-Manson, Gordon Murphy, Peter Rumney, Diann Superina, Jentein Vermaat,
Fred Weinberg clinical fellows Abdullaziz Al Saman, Abdullaziz Al Ruwaishid,
Mubeen Fatima Rafay, Shahnaz Ibrahim, Adel Mahmoud, Evangeline Wassmer
epilepsy fellows Dave Clarke, Shahid Parvez stroke fellow Meredith
Golomb developmental fellows Cara Dosman, Carolyn Hunt, Nicola
Jones-Stokreef, Anne Kawamura, Tara Kennedy, Lana Weaver clinical research
fellow Michael Salman research fellow Shiro Chitoku residents Suad
Al-Otaibi, Rand Askalan, Asif Doja, Cecil Hahn, Jonathan Ponesse
The major foci of the clinical activities of the Neurology
Division are epilepsy, stroke, headache, neurometabolic
disease, neuromuscular disease, sleep disorders,
movement disorders, multiple sclerosis, autism,
developmental disorders and functional neuroimaging.
The Neurology Division has a Royal College accredited
training program in Child Neurology as well as
postdoctoral training programs in epilepsy, stroke, and
developmental pediatrics. The latter is in conjunction
with the Bloorview MacMillan Center. In addition, there
are a number of graduate students and postdoctoral
fellows in clinical neurophysiology and molecular and
cellular neurobiology. The research foci of the
Neurology Division is epilepsy (both clinical and basic
research), magnetoencephalography, stroke, dyslexia,
autism, burden of disease and quality of life, attention
deficit disorder/hyperactivity, muscular dystrophy,
multiple sclerosis, fatty acid oxidation disorders, and
molecular and cellular neurobiology.
publications
Akai T, Otsubo H, Pang EW, Rutka JT, Chitoku S, Weiss SK, Snead OC:
Complex central cortex in pediatric patients with malformations of
cortical development. Journal of Child Neurology: 2002.
Al-Rasheed A, Blaser S, Minassian B, Benson L, Weiss S: Cyclosporine A
neurotoxicity in a patient with idiopathic renal magnesium wasting.
Pediatric Neurology: 2001: 23: 353-356.
Banwell B. Clinicopathologic Conference: Loss of milestones and
failure to thrive in a 28 month old male. J Peds 2002; 140(6); 759-
765.
Chitoku S. Otsubo H, Harada Y, Jay V, Rutka, JT, Weiss S, Abdoll M,
Snead OC: Extraoperative cortical stimulation of motor function in
children. Pediatric Neurology: 2001: 24: 344-350.
Chow G, Banwell B, Clarke J. Late-onset GM2 gangliosidosis
presenting as burning dysesthesias. Pediatr Neurol 2001; 25:59-62.
Chuang NA, Otsubo H, Chuang SH: Magnetic resonance imaging in
pediatric epilspy. Top Magnetic Resonance Imaging: 2002: 13: 39-60.
Cortez MA, Cunnane SC, Snead OC: Brain sterols in the AY-9944 rat
model of atypical absence seizures. Epilepsia: 2002: 43: 3-8.
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Division of NEUROLOGY
deVeber G: Editorial comment: Vascular occlusion in Moyamoya: a
multitude of etiologies? Stroke: 2001: 32: 1792.
deVeber G: Stroke and the child's brain: Syndromes, risk factors and
epidemiology. Current Opinions in Neurology. 2002; 15: 133-8.
Current Opinions in Neurology: 2002: 15: 133-8.
deVeber G, Andrew M, Adams C, Canadian Ischemic Stroke Registry
(DL MacGregor): Cerebral sinovenous thrombosis in children. New
England Journal of Medicine: 2001: 345: 417-423.
Donner EJ, Smith C, Snead OC: Sudden unexpected death in pediatric
epilepsy. Neurology: 2001: 57: 430-434.
Fehlings D, Weiss S, Stephens D: Frequent night awakenings in
preschool children referred to a sleep disorders clinic: The role of nonadaptive
sleep associates. Children's Health Care: 2001: 30: 43-55.
Fernandes MA, McAndrews MP, Logan W, Smith ML, Crawley A,
Mikulis D: Determining language lateralization in children:
Comparison of fMRI and dochotic listening. Brain and Cognition:
2001: 47: 200-203.
Golomb M, MacGregor D, Domi T, Armstrong D, McCrindle B,
Mayank S, deVeber G: Presumed pre- or perinatal arterial ischemic
stroke: Risk factors and outcome. Annals of Neurology: 2001: 50:
163-168.
Golomb MR, Weiss SK, Ibrahim SH, deVeber GA: A 15-year-old boy
with central nervous system vasculopathy presenting with the
dysarthria-clumsy hand syndrome. Journal of Child Neurology:
2002: 7: 241.
Hogema BM, Taylor M, Jakobs C, Schutgens RBH, Froestl W, Snead
OC, Grompe M, Gibson KM: Pharmacologic rescue of lethal seizures
in mice deficient for succinate semialdehyde dehydrogenase. Nature
Genetics: 2001:29:212-216.
Jaaskelainen SK, Juel VC, Udd B, Villanova M, Liguori R, Minassian
BA, Falck B, Niemi P, Kalimo H: Electrophysiological findings in Xlinked
kk myopathy with excessive autophagy. Annals of Neurology:
2002: 51: 648-652.
Kolski H, Otsubo H: The Landau-Kleffner syndrome. Advance
Experience Medical Biology: 2002: 497: 195-208.
Kozer E: How high can we go with phenytoin? Therapeutic Drug
Monitoring: 2002:24: 386-9.
MacGregor D: Vertigo. In: Pediatrics in Review: 2002: 10-16.
Mackay M, Weiss S, Snead OC: What is (are) the rational basis(es),
other than trial-and-error experience for current medical treatments?
International Review of Neurobiology Series Academic Press: 2002:
49: 157-184.
McAdam L, Blaser S, Banwell B. Pediatric tumefactive demyelination:
Case series and review of the literature. Pediatr Neurol 2002; 26(1);
18-25.
Ochi A, Otsubo H: Clinical application of EEG dipole analysis.
Pediatric Medicine (Japanese): 2002: 5: 101-106.
Ochi A, Otsubo H, Honda Y, Hara Y, Sharma R, Rutka JT, Chuang SH,
Kamijo K, Kiyuna T, Yamazaki T, Snead OC III:
Electroencephalographic dipoles of spikes with and without
myoclonic jerks caused by epilepsia partialis continua. Journal of
Child Neurology: 2002: 17: 127-131.
Ochi A, Otsubo H, Sharma R, Hunjan A, Rutka JT, Chuang SH, Kamijo
K, Yamazaki T, Quint P, Kurelowech L, Sobel DF, Aung MH, Snead
OC: Comparison of electroencephalographic dipoles on interictal
spikes from prolonged scalp video-electroencephalographic and
magnetoencephalographic dipoles from short-term recording in
children with extraptemporal lobe epilepsy. Journal of Child
Neurology: 2001: 16: 661-667.
Otsubo H, Chitoku S, Ochi A, Jay V, Rutka JT, Smith ML, Elliott IM,
Snead OC: Malignant rolandic-sylvian epilepsy in children:
Diagnosis, treatment and ouctomes. Neurology: 2001: 57: 590-596.
Otsubo H, Ochi A, Elliott I, Chuang SH, Rutka JT, Jay V, Aung M,
Sobel DF, Snead OC III: MEG predicts epileptic zone in lesional