Annual Report 2001 - The Hospital for Sick Children

faculty Shinya Ito – Chief, Patricia Harper, Gideon Koren, Margaret Thompson,
Sylvain Baruchel (cross-appointee), Denis Scolnik (cross-appointee), Anna Taddio
(cross-appointee) part time Lidia Derewlany, Tom Einarson, Neil Shear,
Sheila Jacobson, Rocco Gerace, Bonnie Stevens, Sunita Vohra
clinical fellows Zinaida Levichek, Radinka Boskovic, Irena Nulman,
Eran Kozer, Ran Goldman, Raanan Cohen-Kerem, Tommy Ho, Yelena Potylitsina
research fellows Adriana Costei, Wen Gao, Yaron Yagev
residents Savithiri Ratnapalan, Maria Valois
The Division of Clinical Pharmacology and Toxicology
focuses on a wide range of drug-related issues in
pediatrics. The division is one of the largest and the
most active pediatric pharmacology programs
internationally. Our major clinical activities include a
consultation service, the Motherisk program (the
counseling and information center for drug and other
exposures during pregnancy and lactation), and the
Ontario Regional Poison Information Center. The
division is one of the two major training sites of the
Royal College-accredited Clinical Pharmacology
Residency program of the University of Toronto. Our
research programs focus on drug metabolizing enzymes
and its regulation, drug transporters, placental and
mammary gland drug transport and metabolism, and
reproductive toxicology and teratology.
publications
Addis A, Moretti ME, Ahmed Syed F, Einarson TR, Koren G: Fetal
effects of cocaine: An updated meta-analysis. Reproductive
Toxicology: 2001: 15: 341-369.
Aleksa K, Ito S, Koren G: Developmental renal tubular toxicity: A
hypothetical and experimental approaches. Current Therapeutic
Research: 2001: 62: 930-941.
Aleksa K, Woodland C, Koren G: Young age and the risk for
ifosfamide-induced nephrotoxicity: A critical review of two opposing
studies. Pediatric Nephrology: 2001: 16: 1153-1158.
Anand KS, Abu-Saad HH, Aynsley Green A, Bancalari E, Benini F,
Champion GD, Craig KD, Dangel T, Fournier-Charrier E, Franck LS,
Eckstein Grunau R, Hertel SA, Jacq Z, Aigrain E, Jorch G, Kopelman
BI, Koren G, Larrson B, Marlow N, McIntosh N, Ohlsson A, Olsson
G, Porter F, Richter R, Stevens B, Taddio A: Treating pain in the
newborn. Archives of Pediatrics and Adolescent Medicine: 2001:
155: 173-180.
Atanackovic G, Navioz Y, Moretti ME, Koren G: The safety of higher
than standard dose of doxylamine-pyridoxine (Diclectin) for nausea
and vomiting of pregnancy. Journal of Clinical Pharmacology: 2001:
41: 842-845.
Atanackovic G, Wolpin J, Koren G: Determinants of the need for
hospital care among women with nausea and vomiting of
pregnancy. Clinical and Investigative Medicine: 2001: 24: 90-93.
Bailey B, Lalkin A, Kapur BM, Koren G: Is chronic poisoning with
acetaminophen in children a frequent occurrence in Toronto?
Canadian Journal of Clinical Pharmacology: 2001: 8: 96-101.
Division of CLINICAL PHARMACOLOGY
Bar-Oz B, Berkovitch M, Ford-Jones L, Koren G: Congenital
cytomegalovirus infection. Is there a breakthrough? Canadian
Family Physician: 2001: 47: 1179-1181.
Bar-Oz B, Hackman R, Einarson T, Koren G: Pregnancy outcome after
cyclosporine therapy during pregnancy: a meta-analysis.
Transplantation: 2001: 71: 1051-1055.
Boskovic R, Klein J, Woodland C, Karaskov T, Koren G: The role of the
placenta in variability of fetal exposure to cocaine and
cannabinoids: a twin study. Canadian Journal of Physiology and
Pharmacology: 2001: 79: 942-945.
Brunner M, Guo W, Mitchell GF, Buckett PD, Nerbonne JM, Koren G:
Characterization of mice with a combined suppression of 1 (to) and
1(K, slow). American Journal of Physiology. Heart and Circulatory
Physiology: 2001: 281: H1201-1209.
Carver V, Coyle B, Koren G, Lavigne S, Martinez L, Robertson J, Polifka
J, Stepanuk K: A call for action prevention of fetal exposure to
isotretoin. A position paper by the organization of teratology
information services public affairs committee. Reproductive
Toxicology: 2001: 15: 729.
Costei AM, King SM, Koren G: Update on perinatal HIV. Canadian
Family Physician: 2001: 47: 2221-2222.
Einarson A, Fatoye B, Sarkar M, Lavigne SV, Brochu J, Chambers C,
Mastoiacovo P, Addis A, Matsui D, Schuler L, Einarson TR, Koren G:
Pregnancy outcome following gestational exposure to venlafaxine; a
muliticenter prospective controlled study. American Journal of
Psychiatry: 2001: 158: 1728-1730.
Einarson A, Selby P, Koren G: Abrupt discontinuation of psychotropic
drugs during pregnancy: fear of teratogenic risk and impact of
counselling. Journal of Psychiatry Neurosciences: 2001: 26: 44-48.
Einarson A, Selby P, Koren G: Discontinuing antidepressants and
benzodiazepines upon becoming pregnant: Beware of the risks of
abrupt discontinuation. Canadian Family Physician: 2001: 47:
489-490.
Einarson A, Shuhaiber S, Koren G: Effects of antibacterials on the
unborn child; what is known and how should this influence
prescribing. Paediatric Drugs: 2001: 3: pp 803-816.
Fouladi M, Stempak D, Gammon J, Klein J, Grant R, Greenberg ML,
Koren G, Baruchel S: Phase 1 trial of twice daily regiment of
amifostine with ifosfamide, carboplatin, and etoposide
chemotherapy in children with refractory carcinoma. Cancer: 2001:
92: 914-923.
Gallo M, Koren G: Can herbal products be used safely during
pregnancy ? Focus on echinacea. Canadian Family Physician: 2001:
47: 1727-1728.
Geshundheit B, Cividalli G, Freeman A, Yatziv S, Koren G, Baruchel S:
Cyclosporin A in the treatment of refractory immune
thrombocytopenia purpura in children. European Journal of
Haematology: 2001: 66: 347-351.
Hard ML, Einarson TR, Koren G: The role of acetaldehyde in
pregnancy outcome after prenatal alcohol exposure. Therapeutic
Drug Monitoring: 2001: 23: 427-434.
Hard ML, Raha S, Spino M, Robinson BH, Koren G: Impairment of
pyruvate dehydrogenase activity by acetaldehyde. Alcohol: 2001:
25: 1-8.
Ho E, Collantes A, Kapur BM, Moretti ME, Koren G: Alcohol and
breastfeeding; calculation of time to zero level in milk. Biol Neonate:
2001: 80: 219-222.
Ho E, Tabesh L, Koren G: Characteristics of pregnant women who use
Ecstasy. Neurotoxicology and Teratology: 2001: 23: 561-567.
Ito S: Transplacental treatment of fetal tachycardia: implications of drug
transporting proteins in placenta. Sem Perinatol 2001: 25: 196-201
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