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EMCB-ENVIS Node ENVIRONMENTAL BIOTECHNOLOGY

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<strong>EMCB</strong>-<strong>ENVIS</strong> Centre<br />

dimethyltin dichloride and 9 for trimethyltin chloride. The interactive effect of trimethyltin<br />

chloride and cadmium, as well as that of trimethyltin chloride and chromium, was found to be<br />

synergistic. Also found to be synergistic was the interactive effect of trimethyltin chloride with<br />

cadmium and chromium applied together.<br />

S. Hadjispyrou, A. Kungolos, A. Anagnostopoulos. (Laboratory of Inorganic Chemistry,<br />

Department of Chemical Engineering, Aristotle University of Thessaloniki, 540 06,<br />

Thessaloniki, Greece. Department of Planning and Regional Development, University of<br />

Thessaly, 38334, Volos, Greece). Toxicity, Bioaccumulation, and Interactive Effects<br />

of Organotin, Cadmium, and Chromium on Artemia franciscana. Ecotoxicology and<br />

Environmental Safety, 49(2) (2001), 179-186.<br />

The effects of three organotin compounds––trimethyltin chloride, dimethyltin dichloride, and<br />

dibutyltin diacetate––and two heavy metals––cadmium and hexavalent chromium––on Artemia<br />

franciscana mortality are investigated in this study. Of all the compounds tested in this work,<br />

trimethyltin chloride was, by far, the most toxic. The toxicity order for the five compounds was<br />

trimethyltin chloride>potassium dichromate>dimethyltin dichloride>dibutyltin<br />

diacetate>cadmium chloride. The big difference in toxicity between dialkyltin and trialkyltin was<br />

not accompanied by an equally big difference in bioaccumulation. At a Sn concentration in water<br />

of 10 mg/L, the bioconcentration factor was 50 for dimethyltin dichloride and 75 for trimethyltin<br />

chloride. At a Sn concentration in water of 100 mg/L, the bioconcentration factor for 6 for<br />

dimethyltin dichloride and 9 for trimethyltin chloride. The interactive effect of trimethyltin<br />

chloride and cadmium, as well as that of trimethyltin chloride and chromium, was found to be<br />

synergistic. Also found to be synergistic was the interactive effect of trimethyltin chloride with<br />

cadmium and chromium applied together.<br />

S. Teodorova, R. Metcheva, M. Topashka-Ancheva. (Institute for Nuclear Research and<br />

Nuclear Energy, Bulgarian Academy of Sciences, 72 Tzarigradsko chaussee, 1784, Sofia,<br />

Bulgaria. Institute of Zoology, Bulgarian Academy of Sciences, 1 Tzar Osvoboditel boul.<br />

1000, Sofia, Bulgaria). Bioaccumulation and damaging action of polymetal<br />

industrial dust on laboratory mice Mus musculus alba. I. Analysis of Zn, Cu, Pb,<br />

and Cd disposition and mathematical model for Zn and Cd bioaccumulations.<br />

Environmental Research, 91(2) (2003), 85-94.<br />

The concentrations of Zn, Cu, Pb, and Cd in the liver, kidneys, spleen, bones, and carcass of<br />

laboratory mice BALB/cy were observed in toxicological experiments. Polymetal industrial dust<br />

containing these metals was given to experimental animals at 1% concentration mixed with<br />

conventional animal food. Samples for analyses were taken on Days 15, 40, 60, 90, and 120<br />

posttreatment. The experimental data clearly support the established antagonistic interactions<br />

among cadmium, zinc, copper, and lead. A mathematical model was proposed to study the main<br />

tendencies of heavy metal bioaccumulation under conditions of metal interaction and excessive<br />

exposure. The experimental results were assessed on the basis of the model. A rate constant of<br />

renal excretion greater than that of hepatic excretion was obtained, which agrees with the<br />

observed inversion of cadmium kidney/liver ratio in the conditions of very high exposure.<br />

S. Teodorova, R. Metcheva, M. Topashka-Ancheva. (Institute for Nuclear Research and<br />

Nuclear Energy, Bulgarian Academy of Sciences, 72 Tzarigradsko chaussee, 1784, Sofia,<br />

Bulgaria. Institute of Zoology, Bulgarian Academy of Sciences, 1 Tzar Osvoboditel boul.<br />

1000, Sofia, Bulgaria). Bioaccumulation and damaging action of polymetal<br />

industrial dust on laboratory mice Mus musculus albaI. Environmental Research,<br />

91(2) (2003), 85-94.<br />

The concentrations of Zn, Cu, Pb, and Cd in the liver, kidneys, spleen, bones, and carcass of<br />

laboratory mice BALB/cy were observed in toxicological experiments. Polymetal industrial dust<br />

containing these metals was given to experimental animals at 1% concentration mixed with<br />

42<br />

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