Alan E. Hubbard - Alan Hubbard - University of California, Berkeley

Office Address
School of Public Health
Division of Biostatistics
113B Haviland Hall
Mailing Address
101 Haviland Hall, MC 7358
University of California
Berkeley, CA 94720
Office Phone: (510)643-6160
Fax: (510)643-5163
email: hubbard@berkeley.edu
webpage: hubbard.berkeley.edu
Education
Ph.D. in Biostatistics, 1998. U.C. Berkeley, CA.
Alan E. Hubbard
M.S. Geology/Paleontology 1990. Virginia Polytechnic University, Blacksburg, VA.
B.A. in Geology, 1985. U.C. Santa Barbara, CA.
Teaching Experience
Associate Professor of Biostatistics, U.C. BERKELEY (7/06-present). Currently teaching courses in
Longitudinal Data Analysis, Statistics of Epidemiology, Methods in Social Epidemiology, Causal
Inference Workshop, Advise graduate students in Biostatistics, Epidemiology, Integrative Biology,
ESPM , Social Welfare, Education, Statistics.
Adjunct Assistant Professor of Biostatistics, U.C. BERKELEY (7/98-present). Have taught 5 graduate
courses in the School of Public Health including the statistical analysis of epidemiological data,
computational biology (analysis of gene-expression data), longitudinal data analysis, survival analysis,
locally efficient estimation and causal inference. Advise graduate students in Epidemiology, Health
Economics, Biostatistics, Social Welfare, ESPM, Psychology.
Lecturer in Biostatistics, U.C. BERKELEY (1/98-6/98). Co-taught and organized an introductory
course in risk research for students in public health as well as a graduate level data analysis workshop
on survival data.
Instructor, U.C. BERKELEY, (1/97-12/97). Developed and taught course on repeated measures
analysis for biostatistics and epidemiology graduate students and taught the risk analysis data
workshop, which is a graduate level course on the analysis of epidemiological data.
Short Courses/Workshops
• International Center For Diarrheal Disease Research, Bangladesh, Semiparametric
Estimation, Dhaka, Bangladesh, Feb. 2012.
• Makerere University, Statistics for Epidemiology, Kampala, Uganda, June 2011.
• BRFSS conference sponsored by Centers for Disease Control, Atlanta, Multilevel Survey
Analysis , March, 2011.
• Centers for Disease Control, Atlanta, Semi-parametric Models for Causal Inference,
March, 2010.
• International Center For Diarrheal Disease Research, Bangladesh, Statistics for
Epidemiology, Dhaka, Bangladesh, Sept-Dec. 2009.

• Graduate Summer Session in Epidemiology, Introduction to Logistic and Poisson Models,
Analysis of Epidemiologic Data: An Applied Approach, Causal Inference and Causal
Regression Models in Epidemiology, 2005-2010.
• Sichuan Centers for Disease Control and Prevention, Analysis of Infectious Disease
Outbreaks, December 2005, Chengdu, China.
• Universidad San Francisco de Quito, Introduction to Public Health Statistics, June 2005,
Quito, Ecuador.
• Mediterranean School of Epidemiology, Applied Linear Models, June 2003, Siracusa, Italy.
• Palm Oil Research Institute, Introduction to Computational Biology, January 2002, Kuala
Lumpur, Malaysia.
Working Experience
Researcher and Adjunct: BUCK INTSTITUTE OF AGING RESEARCH. (6/05-present), Novato, CA.
Development of new statistical methodologies and data analysis in computational biology.
Research Statistician, U.C. BERKELEY, ENVIRONMENTAL HEALTH SCIENCES, (7/99-present),
Berkeley, CA. Development of new statistical methodologies and data analysis in fields of toxicology
and environmental.
Research Statistician, CALIFORNIA STATE OFFICE OF AIDS. (7/99-7/01), Berkeley, CA. Serve as
consulting statistician and conducting independent research on the impact of new treatments on the
survival after diagnosis of AIDS.
Research Statistician, CALIFORNIA HEALTH DEPT., REPRODUCTIVE EPIDEMIOLOGICAL
SECTION (1/94-1/99), Emeryville, CA. Data analysis, development of statistical methodologies and
study design in projects involving spontaneous abortion, menstrual function and semen quality.
Private Statistical Consultant (1994-present), includes:
• Consultant for Entrix, in collaboration with US Forest Service examining the impacts on insect
density of controlled recreational releases on the Feather River.
• Contracted by California Dept. of Fish and Game to develop Salmon population model in San
Joaquin River System. Testified before California State Water Board.
• Evaluation of clinical trials for veterinarian drugs for Aspen Biosystems.
• Evaluation of Affymetrix chip variability for Ambion.
• Model to detect unique visitors on newspaper internet websites, Belden Associates.
• Designed and taught computational biology short course to research institute in Malaysia for
Amersham Biosciences.
• Legal consulting for Analysis Group, Palo Alto.
• Legal consulting for Levy, Angstreich, Finney
• Examining success of program to reduce teenage pregnancy and STD’s for Center of
Reproductive Health Policy and Research, Institute for Heath Policy Studies, UCSF.
• Designing instrument to predict mortality and tumor growth using remote sensing technology for
Xenogen corporation, Alameda.
• Monitoring the effectiveness of TB control program in California State Prisons for California
Department of Health Services.
• Examining health utilization of recent immigrants for San Francisco City Health Department.
• A longitudinal study of AIDS patients at the VA Hospital in San Francisco.
• A study of absenteeism in postal workers in Sacramento for Ogden Environmental.
• Statistical support for clinical trial testing a new treatment of infant botulism, California
Department of Health Services.
• Examined the association of air quality and rates of respiratory disease in Richmond, CA for the
plaintiffs (Larry Padway) in an environmental tort case.
Geologist, ARCO OIL & GAS COMPANY (1990-1993), Houston, TX. Exploration geology.

Environmental Geologist, PETROLEUM INDUSTRY CONSULTANTS (11/86-11/88), Huntington
Beach, CA. Hazardous waste management and remediation.
Affiliations
Member of the Center for Occupational and Environmental Health
American Statistical Association
Buck Institute of Aging Research
Faculty mentor for Robert Woods Johnson Scholars, Health and Society Scholars Program
Editorial Positions
Associate editor for Statistical Applications in Genetics and Molecular Biology
Associate editor for International Journal of Biostatistics
Associate editor for PlosONE
Publications/Submitted Manuscripts
Crane, J., Ogborn, D., Cupido, C., Melov, S., Hubbard, A., Bourgeois, J., and Tarnopolsky, M. 2012.
Massage Therapy Attenuates Inflammatory Signaling After Exercise-Induced Muscle Dam-
age. Science Translational Medicine, 4(119).
Marston, D., Mesick, C., Hubbard, A., Stanton, D., Fortmann-Roe, S., and Tsao, S. 2011. Delta flow
factors influencing stray rate of escaping adult san joaquin river fall-run chinook salmon
(oncorhynchus tshawytscha). In review at SFEWS.
Padula, A., Mortimer, K., Hubbard, A.E., Lurmann, F. and Tager, I. 2012. Exposure to Traffic
Related Air Pollution During Pregnancy and Term Low Birth Weight: Estimation of Causal
Associations in a Semi-parametric model. In press at American Journal of Epidemiology.
Fleischer, N., Diez Roux, A., and Hubbard, A. 2012. Inequalities in Body Mass Index and Smoking
Behavior in 70 Countries: Evidence for a Social Transition in Chronic Disease Risk. American
Journal of Epidemiology, 175(3):167–176.
Levy, K., Nelson, K., Hubbard, A. and Eisenberg, J. 2011. Rethinking indicators of microbial drinking
water quality for health studies in tropical developing countries: case study in northern coastal
ecuador. Am J Trop Med Hyg, 86(3): 499–507.
Smith, K. McCracken, J. Weber, M. Hubbard, A., Jenny, A., Thompson, L., Balmes, J., Diaz, A.,
Arana, B., and Bruce, N. 2011. Effect of reduction in household air pollution on childhood
pneumonia in guatemala (respire): a randomised controlled trial. Lancet 378(9804): 1717–
1726.
Margerison- Zilko, C., Catalano, R., Hubbard, A., Ahern, J. 2011. Maternal Exposure to Unexpected
Economic Contraction and Birth Weight for Gestational Age. Epidemiology 22(6):855–858.
Jamshidian, F., Hubbard, A. and Jewell, N. 2011. Accounting for perception, placebo and unmasking
effects in estimating treatment effects in randomised clinical trials. Stat Methods Med Res
[Epub ahead of print].
Hubbard, A., Jewell, N. P., and van der Laan, M. J. 2011. Direct Effects and Effect Among the
Treated. Targeted Learning. van der Laan and Rose (eds). Springer, 2011, ch. 8, pp. 133–43.

Lo, R., Hubbard, A., Shaw, L., Trojanowski, J., Petersen, R., Aisen, P., Weiner, M. and Jagust, W.
2012. Longitudinal Change of Biomarkers in Cognitive Decline. Archives of Neurology
68(10):1257–1266.
C. M. McHale, L. Zhang, Q. Lan, R. Vermeulen, G. Li, A. E. Hubbard, K. E. Porter, R. Thomas, C. J.
Portier, M. Shen, S. M. Rappaport, S. Yin, M. T. Smith, and N. Rothman. Global gene
expression profiling of a population exposed to a range of benzene levels. Environ Health
Perspect, 119(5):628–34, May 2011.
Mackey, D. C., Hubbard, A. E., Cawthon, P. M., Cauley, J. A., Cummings, S. R., and Tager, I. B.
2011. Usual Physical Activity and Hip Fracture in Older Men: An Application of
Semiparametric Methods to Observational Data. Am J Epidemiol, 173(5): 578–586.
Sadetsky, N., Greene, K., Cooperberg, M., Hubbard, A., Carroll, P. and Satariano, W. 2011. Impact of
Androgen Deprivation on Physical Well-Being in Patients With Prostate Cancer Analysis From
the CaPSURE (Cancer of the Prostate Strategic Urologic Research Endeavor) Registry. Cancer
117(19):4406–4413.
Balazs, C., Morello-Frosch, R., Hubbard, A. and Ray, I. 2011. Social Disparities in Nitrate-
Contaminated Drinking Water in Califor- nia’s San Joaquin Valley. Environmental Health
Perspectives 119(9):1272–1278.
North, M., Tandon, V., Thomas, R., Loguinov, A., Gerlovina, I., Hubbard, A., Zhang, L., Smith, M.
and Vulpe, C. 2011. Genome-Wide Functional Profiling Reveals Genes Required for
Tolerance to Benzene Metabolites in Yeast. PLOS One, 6(8), 2011.
Rogers, A., Chen, D., McColl, G., Czerwieniec, G., Felkey, K., Gibson, B., Hubbard, A., Melov, S.,
Lithgow, G., and Kapahi, P. 2011. Life Span Extension via eIF4G Inhibition Is Mediated by
Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans. Cell
Metabolism 14(1):55–66.
Greenhouse, B., Ho, B., Hubbard, A., Njama-Meya, D., Narum, D., Lanar, D., Dutta, S., Rosenthal, P.,
Dorsey, G., and John, C. 2011. Antibodies to Plasmodium falciparum Antigens Predict a
Higher Risk of Malaria But Protection From Symptoms Once Parasitemic. Journal of
Infectious Disease 204(1):19–26.
Pressman, A., Avins, A., Hubbard, A. and Satariano, W. 2011. A comparison of two worlds: How
does Bayes hold up to the status quo for the analysis of clinical trials? Contemporary Clinical
Trials 32(4):561– 568.
Arnold, B., Hogan, D., Colford, J. and Hubbard, A. 2011. Simulation methods to estimate design
power: an overview for applied research. BMC Medical Research Methodology 11, Article 11.
Powolny, A., Singh, S., Melov, S., Hubbard, A. and Fisher, A. 2011. The garlic constituent diallyl
trisulfide increases the lifespan of C. elegans via skn-1 activation. Experimental Gerontology
46(6):441–452.
McCulloch, M., Broffman, M., van der Laan, M., Hubbard, A., Kushi, L., Abrams, D., Gao, J. and
Colford, J. 2011. Colon Cancer Survival With Herbal Medicine and Vitamins Combined With
Standard Therapy in a Whole-Systems Approach: Ten-Year Follow-up Data Analyzed With
Marginal Structural Models and Propensity Score Methods. Integrative Cancer Therapies
10(3):240–259.

McCulloch, M., Broffman, M., van der Laan, M., Hubbard, A., Kushi, L., Kramer, A., Gao, J. and
Colford, J. 2011. Lung Cancer Survival With Herbal Medicine and Vitamins in a Whole-
Systems Approach: Ten-Year Follow-up Data Analyzed With Marginal Structural Models and
Propensity Score Methods. Integrative Cancer Therapies 10(3):260–279.
Flynn, J. M., Choi, S. W., Day, N. U., Gerencser, A. A., Hubbard, A., and Melov, S. 2011. Impaired
spare respiratory capacity in cortical synaptosomes from sod2 null mice. Free Radic Biol Med,
50(7): 866–73.
Zhang, L., Lan, Q., Guo, W., Hubbard, A. E., Li, G., Rappaport, S. M., McHale, C. M., Shen, M., Ji,
Z., Vermeulen, R., Yin, S., Rothman, N., and Smith, M. T. Chromosome-wide aneuploidy
study (CWAS) in workers exposed to an established leukemogen, benzene. 2011.
Carcinogenesis 32(4): 605–612.
Quiros-Alcala, L., Bradman, A., Nishioka, M., Harnly, M. E., Hubbard, A., McKone, T. E., Ferber, J.,
and Eskenazi, B. 2011. Pesticides in house dust from urban and farmworker households in
california: an observational measurement study. Environmental Health, 10(19).
McCoy, S. I., Jewell, N. P., Hubbard, A., Gerdts, C. E., Doherty, I. A., Padian, N. S., and Minnis, A.
M. A. 2010. Trajectory analysis of alcohol and marijuana use among Latino adolescents in
San Francisco, California. J Adolesc Health, 47(6): 564–74.
Arnold, B. F., Khush, R. S., Ramaswamy, P., London, A. G., Rajkumar, P., Ramaprabha, P., Durairaj,
N., Hubbard, A. E., Balakrishnan, K., and Colford, Jr, J. M. 2010. Causal inference methods to
study nonrandomized, preexisting development interventions. Proc Natl Acad Sci USA,
107(52): 22605–10.
Hubbard, A.E., Ahern, J., Fleischer, N., van der Laan, M., Lippman, S., Bruckner, T. and Satariano, W.
2010. To gee or not to gee: comparing population average and mixed models for estimating the
associations between neighborhood risk factors and health (with commentary and reply).
Epidemiology, 21(4):467–740.
Goldstein, B., Hubbard, A.E., Cutler, A., and Barcellos, L. 2010. An application of random forests to a
genome-wide association dataset: methodological considerations & new findings. BMC Genet
11:49.
Cheng, Y., Hubbard, A., Caughey, A., and Tager, I. 2010. The association between persistent fetal
occiput posterior position and perinatal outcomes: an example of propensity score and
covariate distance matching. Am J Epidemiol, 171(6):656–63.
Sudat, S., Carlton, E., Seto, E., Spear, R., and Hubbard, A.E. 2010. Using variable importance
measures from causal inference to rank risk factors of schistosomiasis infection in a rural
setting in china. Epidemiol Perspect Innov: 7:3.
Satariano, W., and Ivey, S., Kurtovich, E., Kealey, M., Hubbard, A., Bayles, C., Bryant, L., Hunter,
R., and Prohaska, T. 2010. Lower-body function, neighborhoods, and walking in an older
population. Am J Prev Med, 38(4):419–28.
MacNeil, L., Melov, S., Hubbard, A., Baker, S., and Tarnopolsky, M. 2010. Eccentric exercise
activates novel transcriptional regulation of hypertrophic signaling pathways not affected by
hormone changes. PLoS One, 5(5):e10695.
Carlton, E., Hsiang, M., Zhang, Y., Johnson, S., Hubbard, A., and Spear, R. 2010. The impact of
schistosoma japonicum infection and treatment on ultrasound-detectable morbidity: a five-year
cohort study in southwest china. PLoS Negl Trop Dis, 4(5):e685.

Steinmaus, C., Yuan, Y., Kalman, D., Rey, O., Skibola, C., Dauphine, D., Basu, A., Porter, K.,
Hubbard, A., Bates, M., Smith, M., and Smith, A. 2010. Individual differences in arsenic
metabolism and lung cancer in a case-control study in Cordoba, Argentina. Toxicol Appl
Pharmacol 247(2):138–45.
Kristin E Porter, Anamika Basu, Alan E Hubbard (advisor to student 1 st author), Michael N Bates,
David Kalman, Omar Rey, Allan Smith, Martyn T Smith, Craig Steinmaus, Christine F
Skibola. Association of genetic variation in cystathionine-beta-synthase and arsenic
metabolism. 2010. Environ Res: 110(6):580–7. 2010.
Zhang, L., et al., (with Hubbard, A.). 2010. Systems biology of human benzene exposure. Chem Biol
Interact, 184:86–93.
Weldon, R., Webster, M., Harley, K., Bradman, A., Fenster, L., Davis, M., Hubbard, A., Barr, D.,
Holland, N., Eskenazi, B. 2010. Serum persistent organic pollutants and duration of lactation
among mexican-american women. J Environ Public Health: 861757, 2010.
McHale, C.M., Zhang, L., Hubbard, A.E. and Smith, M.T. 2010. Toxicogenomic profiling of
chemically exposed humans in risk assessment. In press at Mutat Res. 705(3):172-83.
McColl, G., Rodgers, A., Alavez, S., Hubbard, A.E., Link, C.D., Kapahi, P. and Lithgow, G.J. 2010.
Insulin-like Signaling Determines Survival During Stress via Post Transcriptional Mechanisms
in C. elegans. Cell Metab, 12(3):260–72.
Rocca C., Doherty, I., Padian, N., Hubbard, A.E. and Minnis, A. 2010. Pregnancy intentions and
teenage pregnancy among Latinas: a mediation analysis. Perspect Sex Reprod Health:
42(3):186–96.
Krishnan, S., Rocca, C.H., Hubbard, A.E., Subbiah, K., Edmeades, J., Padian, N.S. 2010. Do changes
in spousal employment status lead to domestic violence? Insights from a prospective study in
Bangalore, India. Social Science and Medicine 70: 136-43.
Zhang, Luoping, Tang, Xiaojiang, Rothman, Nathaniel, Vermeulen, Roel, Ji, Zhiying, Shen, Min, Qiu,
Chuangyi, Guo, Weihong, Liu, Songwang, Reiss, Boris, Freeman, Laura Beane, Ge, Yichen,
Hubbard, Alan E., Hua, Ming, Blair, Aaron, Galvan, Noe, Ruan, Xiaolin, Alter, Blanche P.,
Xin, Kerry X., Li, Senhua, Moore, Lee E., Kim, Sungkyoon, Xie, Yuxuan, Hayes, Richard B.,
Azuma, Mariko, Hauptmann, Michael, Xiong, Jun, Stewart, Patricia, Li, Laiyu, Rappaport,
Stephen M., Huang, Hanlin, Fraumeni, Jr., Joseph F., Smith, Martyn T., Lan, Qing. 2010.
Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific
Chromosome Changes in Cultured Myeloid ProgenitorCells. Cancer Epidemiology,
Biomarkers and Prevention 19:80-88.
Gupta, V., Dorsey, G, Hubbard, A. E., Rosenthal, P. J. and Greenhouse, B. 2010. Gel versus capillary
electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in
Uganda. Malaria Journal 9(19) http://www.malariajournal.com/content/9/1/19.
Cheng, Y.W., Hubbard, A.E., Caughey, A.B. and Tager, I.B. 2010. Use of Propensity Scores to
Estimate the Effect of Persistent Occiput Posterior on Perinatal. American Journal of
Epidemiology 171: 656-63.
Fleischer, N.L., Fernald, N., and Hubbard, A.E. (Senior author). 2010. Estimating the potential impacts
of intervention from observational data: methods for estimating causal attributable risk in a
cross-sectional analysis of depressive symptoms in Latin America. Journal of Epi &
Community Health. 64: 16-21.

Abadi, A., Glover, E.I., Isfort, R.J., Raha, S., Safdar, A., Yasuda, N., Kaczor, J.J., Melov, S., Hubbard,
A., Qu, X.Y., Phillips, S.M., Tarnopolsky, M. 2009. Limb Immobilization Induces a
Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and
Women. PLoS ONE 4: e6518.
Spear, R.C. and Hubbard, A.E. 2009. Parameter Estimation and Site-specific Calibration of Disease
Transmission Models. Infectious Disease Transmission Modeling and Management of Parasite
Control, Michael, E. and Spear, R.C. (eds.), Springer Science+Business Media.
Chettier, R., Hubbard, A. (co-first authors), Miller, J., Bell. R., Chen, D., Kapahi, P., Tarnopolsky, M.,
Sahasrabuhde, S., Melov, S. and Hughes, R.E. 2009. A human protein interaction network
providing evidence for general conservation of aging processes in human and invertebrate
species. PLoS Genet. Mar;5(3):e1000414.
Arnold, B., Arana, B., Mausezahl, D., Hubbard, A., Colford, J.M. 2009. Evaluation of a pre-existing,
3-year household water treatment and handwashing intervention in rural Guatemala.
International Journal of Epidemiology 38: 1651-61.
Ahern, J., Hubbard, A.E. and Galea, S. 2009. Estimating the effects of potential public health
interventions on population disease burden: a step-by-step illustration of causal inference
methods. American Journal of Epidemiology 169:1140–7.
Huen, K., Harley, K., Brooks, J., Hubbard, A., Bradman, A., Eskenazi, B. and Holland, N. 2009.
Developmental Changes in PON1 Enzyme Activity in Young Children and Effects of PON1
Polymorphisms. 2009. Environmental Health Perspectives 117: 1632-38.
Samper, E., Morgado, L. Estrada, J.C., Bernad, A., Hubbard, A.E., Cadenas, S. and Melov, S. 2009.
Increase in mitochondrial biogenesis, oxidative stress and glycolysis in murine lymphomas.
Free Radical Biology & Medicine 46(3):387-96.
Levy, K., Hubbard, A. and Eisenberg, J. 2009. Seasonality of Rotavirus Disease in the Tropics: A
Systematic Review and Meta-analysis. International Journal of Epidemiology 38: 1487-96.
Levy, K., Hubbard, A., Nelson, K. and Eisenberg, J. 2009. Drivers of Water Quality Variability in
Northern Coastal Ecuador. Environmental Science & Technology 43(6):1788–97.
Greenhouse, B., Slater, M., Njama-Meya, D., Nzarubara, B., Maiteki-Sebuguzi, C., Clark, T.D.,
Staedke, S.G., Kamya, M.R., Hubbard, A.E., Rosenthal, P.J. and Dorsey, G. 2009. Decreasing
Efficacy of Antimalarial Combination Therapy in Uganda Explained by Decreasing Host
Immunity Rather than Increasing Drug Resistance. Journal of Infectious Disease 199(5):758-
65.
Guendelman S., Pearl M., Graham S., Hubbard A., Hosang N. and Kharrazi M. 2009. Maternity leave
in the ninth month of pregnancy and birth outcomes among working women. Womens Health
Issues 19:30-7.
Golden, T., Hubbard, A. (co-first authors), Dando, C., Herren, M.A. and Melov, S. 2008. Age-related
behaviors have distinct transcriptional profiles in C.elegans. Aging Cell 7: 850–865.
Levy, K., Nelson, K., Hubbard, A. and Eisenberg, J. 2008. Following the Water: A Controlled Study
of Drinking Water Storage in Northern Coastal Ecuador. Environmental Health Perspectives
116: 1533-40.
Machekano, R.N., Dorsey, G., Hubbard, A. 2008. Efficacy Studies of Malaria Treatments in Africa:
Efficient Estimation with Missing Indicators of Failure. Statistical Methods in Medical
Research 17: 191-206.

Ahern J., Galea S., Hubbard A., Syme S.L. 2008. Neighborhood smoking norms modify the relation
between collective efficacy and smoking behavior. Drug and Alcohol Dependence 100: 138-
45.
Johnson, DR; Brodie, EL; Hubbard, AE; Andersen, GL; Zinder, SH; Alvarez-Cohen, L. 2008.
Temporal transcriptomic microarray analysis of "Dehalococcoides ethenogenes" strain 195
during the transition into stationary phase . Applied and Environmental Microbiology 74: 2864-
2872.
Skibola, C.F., Nieters, A., Bracci, P.M., Curry, J.D., Agana, L., Skibola, D.R., Hubbard, A., Becker,
N., Smith, M.T, Holly, E.A. 2008. A functional TNFRSF5 gene variant is associated with risk
of lymphoma. Blood 111: 4348-54.
Ahern J., Galea S., Hubbard, A., Midanik, L., Syme, S.L. 2008. Culture of drinking" and individual
problems with alcohol use. American Journal of Epidemiology 167: 1041-49.
Escobar, P.A., Smith, M.T., Vasishta, A., Hubbard, A.E. and Zhang, L. 2007. Leukaemia-specific
chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH).
Mutagenesis 22:321-7.
Zhang, L., Rothman, N., Li, G., Guo, W., Yang, W., Hubbard, A.E., Hayes, R.B., Yin, S., Lu, W. and
Smith, M.T. 2007. Aberrations in chromosomes associated with lymphoma and therapy-related
leukemia in benzene-exposed workers. Environ Mol Mutagen 48:467-74.
McColl, G., Killilea, D.W., Hubbard, A.E., Vantipalli, M.C., Melov, S. and Lithgow. G.J. 2007.
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. Journal
of Biological Chemistry 283: 350-7.
Ahern J, Galea S, Hubbard A, Karpati A. 2008. Population vulnerabilities and capacities related to
health: a test of a model. Social Science and Medicine 66: 691-703.
Galea, S., Ahern, J., Tracy, M., Hubbard, A., Cerda, M., Goldmann, E. and Vlahov, D. 2008. The
longitudinal determinants of post-traumatic stress in a population-based cohort study.
Epidemiology 19:47-54.
Trostle, J., Hubbard, A., Scott, J., Cevallos, W., Bates, S. and Eisenberg, J. 2008. Raising the level of
analysis of food-borne outbreaks - Food-sharing networks in rural coastal Ecuador.
Epidemiology 19: 384-90.
Hubbard, A.E. and van der Laan, M. 2007. Population Intervention Models. Biometrika 95:35-47
Enanoria, W., Hubbard, A.E., van der Laan, M.J., Chen, M., Ruiz, J. and Colford, J.M. 2007. Early
prediction of median survival among a large AIDS surveillance cohort. BMC Public Health
7:127.
Chen, J., van der Laan, M., Smith M.T. and Hubbard, A.E. (Senior Author). 2007. A Comparison of
Methods to Control Type I Errors in Microarray Studies. Statistical Applications in Genetics
and Molecular Biology Vol. 6 : Iss. 1, Article 28. Available at:
http://www.bepress.com/sagmb/vol6/iss1/art28
van der Laan, M., Polley, E.C., and Hubbard, A.E. 2007. Super Learning. Statistical Applications in
Genetics and Molecular Biology: Vol. 6 : Iss. 1, Article 25. Available at:
http://www.bepress.com/sagmb/vol6/iss1/art25

Yau, C., Fedele, V., Roydasgupta, R., Fridlyand, J., Hubbard, A.E., Gray, J.W., Chew, K., Dairkee,
S.H., Moore, D.H., Tommasi, S., Paradiso, A., Albertson, D.G. and Benz. C.C. 2007. Aging
Impacts Transcriptome but not Genome of Hormone-dependent Breast Cancers. Breast
Cancer Research 9: R59.
Lippman, S.A., Pulerwitz, J., Chinaglia, M., Hubbard, A., Reingold, A. and Diaz, J. 2007. Mobility
and its liminal context: exploring sexual partnering among truck drivers crossing the Southern
Brazilian border. Social Science and Medicine 65:2464-73
Remais, J., Hubbard, A.E., Zisong, W., Spear, R.C. 2007. Weather-driven dynamics of an intermediate
host: mechanistic and statistical population modelling of Oncomelania hupensis. Journal of
Applied Ecology 44: 781–91.
Edwards, R., Hubbard, A., Khalakdina, A., Pennise, D. and Smith, K.R. 2007. Design considerations
for field studies of changes in indoor air pollution due to improved stoves. Energy for
Sustainable Development 11: 71-81.
Birkner, M.D., Kalantri, S.P., Solao, V., Badam, P., Joshi. R., Goel, A., Pai, M. and Hubbard, A.E.
(Senior Author). 2007. Creating diagnostic scores using data-adaptive regression: An
application to prediction of 30-day mortality among stroke victims in a rural hospital in India.
Therapeutics and Clinical Risk Management 3: 475-84.
Melov, S., Tarnopolsky, M.A., Beckman, K., Felkey, K., Hubbard, A. 2007. Resistance Exercise
Reverses Aging in Human Skeletal Muscle. PLoS ONE 2(5).
Melov, S., Adlard, P.A., Morten, K., Johnson, F., Golden, T.R., Hinerfeld, D., Schilling, B., Mavros,
C., Masters, C.L., Volitakis, I., Li, Q., Laughton, K., Hubbard, A.E., Cherny, R.A., Gibson, B.,
Bush, A.E. 2007. Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau. PLoS
ONE 2(6).
Bates, S.J., Trostle, J., Cevallos, W.T., Hubbard, A.E. and Eisenberg, J.N.S. 2007. Relating diarrheal
disease to social networks and the geographic configuration of communities in rural Ecuador.
Accepted in American Journal of Epidemiology 166: 1088-95.
Greenhouse, B., Dokomajilar, C., Hubbard, A.E., Rosenthal, P.J. and Dorsey, G. 2007. Impact of
Transmission Intensity on the Accuracy of Genotyping to Distinguish Recrudescence from
New Infection in Antimalarial Clinical Trials. Antimicrobial Agents and Chemotherapy 51:
3096-103.
Fleischer, N.L., Fernald, L. and Hubbard, A.E. 2007. Correlates of depressive symptoms in a large
sample of low-income women in rural Mexico. Epidemiology 18: 678-85.
Brown, J.M., Wald, A., Hubbard, A.E., Bakka, H., Rungruengthanakit, K., Moncada, J., Chipato, T.,
Rugpao, S., Mmiro, F., Celentano, D.D., Salata, R.S., Morrison, C.S., Richardson, B. and
Padian, N.S. 2007. Incident and Prevalent Herpes Simplex Virus Type 2 Infection Increases
Risk of HIV Acquisition among Women In Uganda and Zimbabwe. AIDS 21:1515-23.
Malamba, S.S., Mermin, J., Reingold, A., Lule, J.R., Downing, R., Ransom, R., Kigozi, A., Hunt,
B.M., Hubbard, A., Rosenthal, P.J. and Dorsey, G. 2006. Effect of cotrimoxazole prophylaxis
taken by human immunodeficiency virus (HIV)-infected persons on the selection of
sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household
members. Am J Trop Med Hyg. 75:375-80.

Olaharski, A.J., Ji, Z., Woo, J.Y., Lim, S., Hubbard, A.E., Zhang, L. and Smith, M.T. 2006. The
histone deacetylase inhibitor trichostatin a has genotoxic effects in human lymphoblasts in
vitro. Toxicol Sci. 93: 341-7.
Golden, T.R., Hubbard, A. and Melov, S. 2006. Microarray analysis of variation in individual aging C.
elegans: approaches and challenges. Exp Gerontol. 41:1040-5.
McHale, C.M., Zhang, L., Hubbard, A.E., Zhao, X., Baccarelli, A., Pesatori, A.C., Smith, M.T. and
Landi, M.T. 2007. Microarray analysis of gene expression in peripheral blood mononuclear
cells from dioxin-exposed human subjects. Toxicology 229:101-13.
Fenster, L., Eskenazi, B., Anderson, M., Bradman, A., Hubbard, A.E. and Barr, D.B. 2007. In utero
exposure to DDT and performance on the Brazelton neonatal behavioral assessment scale.
Neurotoxicology 10.
Holland, N., Harmatz, P., Golden, D., Hubbard, A.E., Wu, Y.Y., Bae, J., Chen, C., Huen, K. and
Heyman, M.B. 2007. Cytogenetic damage in blood lymphocytes and exfoliated epithelial cells
of children with inflammatory bowel disease. Pediatr Res. 2007 61:209-14.
Golden, T.R., Beckman, K.B., Lee, A.H., Dudek, N., Hubbard, A.E., Samper, E. and Melov, S. 2007.
Dramatic age-related changes in nuclear and genome copy number in the nematode
Caenorhabditis elegans. Aging Cell. 6:179-88.
Liang S., Seto E.Y., Remais J.V., Zhong B., Yang C., Hubbard A.E., Davis G.M., Gu X., Qiu D. and
Spear R.C. 2007. Environmental effects on parasitic disease transmission exemplified by
schistosomiasis in western China. Proc. Natl. Acad. Sci. 104:7110-5.
Wilson M.P., Hammond S.K., Nicas M., and Hubbard A.E. 2007. Worker exposure to volatile organic
compounds in the vehicle repair industry. J Occup Environ Hyg. 4:301-10.
Sandhu, S.K., Priest, J.W., Lammie, P.J., Hubbard, A.E., Colford, J.M., and Eisenberg, J.N.S. 2006.
The natural history of antibody responses to Cryptosporidium parasites in men at high risk of
HIV infection. Journal of Infectious Diseases 194: 1428-1437
Eisenberg, J.N.S., Hubbard, A.E., Wade, T.J., Sylvester, M.D., LeChevallier, M.W., Levy, D.A.,
Colford, J.M. 2006. Inferences drawn from a risk assessment compared directly with a
randomized trial of a home drinking water intervention. Environmental Health Perspectives
114: 1199-204.
van der Laan, M., Hubbard, A.E., Jewell, N.P. 2007. Estimation of Treatment Effects in Randomized
Trials with Noncompliance and a Dichotomous Outcome. Journal of the Royal Statistical
Society: Series B (Statistical Methodology) 69: 463–482.
Eisenberg, J., Cevallos. W., Ponce, K., Levy, K., Bates, S.J., Scott, J., Hubbard. A., Vieira, N., Endara,
P., Espinel, M., Trueba, G., Riley, L. and Trostle, J. 2007. Environmental change in the form of
new roads affects the transmission of diarrheal pathogens in rural Ecuador. PNAS 103: 19460-
5.
van der Laan, M. and Hubbard, A.E. 2006. Quantile-Function Based Null Distribution in Resampling
Based Multiple Testing, Statistical Applications in Genetics and Molecular Biology: Vol. 5 :
Iss. 1, Article 14.
Rachowicz, L., Hubbard, A.E., Beissinger, S.R. 2006. Estimating and Comparing Offshore
Distributions of Marbled Murrelets among Different Regions. Ecological Modelling 196: 329-
344

Birkner, M.D., Hubbard, A.E., van der Laan. M.J., Skibola, C., Hegedus, C. and Smith, S. 2006. Issues
of Processing and Multiple Testing of SELDI-TOF MS Proteomic Data. Statistical
Applications in Genetics and Molecular Biology: Vol. 5, Issue 1, Article 11,
http://www.bepress.com/sagmb/vol5/iss1/art11/.
Kim, Y.S., Leventhal, B.L., Koh, Y., Hubbard, A., Boyce, W.T. 2006. School Bullying and Youth
Violence: Causes or Consequences of Psychopathology? Archives of Gen Psychiatry: 63 (9):
1035-1041.
Birkner, M., Hubbard, A., van der Laan, M. 2005. Data Adaptive Pathway Testing. U.C. Berkeley
Division of Biostatistics Working Paper Series. Working Paper 197.
http://www.bepress.com/ucbbiostat/paper197.
Birkner, M.D., Hubbard, A.E., van der Laan. M.J. 2005. Application of a Multiple Testing Procedure
Controlling the Proportion of False Positives to Protein and Bacterial Data Statistical
Applications in Genetics and Molecular Biology: Vol. 4. Article 29.
Liang S, Spear RC, Seto E, Hubbard A, Qiu DC . 2005. A multi-group model of Schistosoma
japonicum transmission dynamics and control: model calibration and control prediction:
Tropical Medicine and international health: 10: 263-278.
Seto, E., Zhong, B., Kouch, J., Hubbard, A., Spear, R.C. 2005. Genetic and Household Risk Factors
for Schistosoma japonicum Infection in the Presence of Larger Scale Environmental
Differences in the Mountainous Transmission Areas of China. Am. J. Trop. Med. Hyg. 73:
1145–1150.
Vevera, J., Hubbard, A.E., Vesley, A., Papezova, H. 2005. Violent Behaviour in Schizophrenia:
Retrospective Study of Four Independent Samples from Prague, 1949 to 2000. The British
Journal of Psychiatry 187: 426-430.
Forrest, M.S. Lan, Q., Hubbard, A.E., Zhang, L., Vermeulen, V., Zhao, X., Li, G-L., Wu, Y-Y., Shen,
M., Yin, S., Chanock, S.J., Rothman, N., Smith, M.T. 2005. Discovery of Novel Biomarkers
by Microarray Analysis of Peripheral Blood Mononuclear Cell Gene Expression in Benzene-
Exposed Workers. Environmental Health Perspectives, Toxicogenomics 113, 6:801-07.
Skibola, D,R,, Smith, M.T., Bracci, P.M., Hubbard, A.E., Agana, L., Chi, S., Holly, E.A. 2005.
Polymorphisms in Ghrelin and Neuropeptide Y Genes are Associated with Non-Hodgkin
Lymphoma. Cancer Epidemiology, Biomarkers and Prevention 14(5):1251-6.
McCulloch, M., Jezierski, T., Broffman, M., Hubbard, A., Turner, K. and Janecki, T. 2005. Diagnostic
Accuracy of Canine Scent Detection in Early- and Late-Stage Lung and Breast Cancers.
Integrative Cancer Therapies 5, 1:30-39.
van der Laan, M., Birkner, M., Hubbard, A. 2005. Empirical Bayes and Resampling Based Multiple
Testing Procedure Controlling Tail Probability of the Proportion of False Positives. Statistical
Applications in Genetics and Molecular Biology 4(1).
http://www.bepress.com/sagmb/vol4/iss1/art29.
Zhang, L., Yang, W., Hubbard, A.E., Smith, M.T. 2005. Nonrandom Aneuploidy of Chromosomes 1,
5, 6, 7, 8, 9, 11, 12, and 21 Induced by the Benzene Metabolites Hydroquinone and
Benzenetriol. Environ Mol Mutagen 45: 388-396.
Zhang, L., Lan, Q., Guo, W., Li, G., Yang, W., Hubbard, A., Vermeulen, R., Rappaport, S., Yin, S.,
Rothman, N., Smith, M. 2005. Use of OctoChrome Fluorescence in situ Hybridization to
Detect Specific Aneuploidy among all 24 Chromosomes in Benzene-Exposed Workers.
Chemical-Biological Interactions 153: 117-122.

Golden. T.R., Hubbard, A.E., Morten, K. Hinerfeld, D., Melov, W. 2005. Pharmacogenomic Profiling
of an Oxidative Stress-Medicated Spongiform Encephalopathy. Free Radical Biology and
Medicine 39:152-163.
Eisenberg, J.N.S., Lei, X., Hubbard, A.E., Brookhart, M.A., Colford, J. 2005. The Role of Disease
Transmission and Conferred Immunity in Outbreaks: Analysis of the 1993 Cryptosporidium
Outbreak in Milwaukee, Wisconsin. American Journal of Epidemiology 161 (1): 62-72.
Qiu, D.-C. Hubbard, A.E., Zhong, B., Zhang, Y., Spear, R.C. 2005. A Matched, Case–Control Study of
the Association Between schistosoma japonicum and Liver and Colon Cancers, in Rural China.
Annals of Tropical Medicine & Parasitology 99: 47-52.
Colford, J.M., Saha, S.R., Wade, T.J., Wright, C.C., Vu, M., Charles, S., Lee, S., Hubbard, A.E.,
Jensen, P., Levy, D.A. and Eisenberg, J.N.S. 2005. A Randomized, Controlled Trial of an In-
Home Drinking Water Intervention Among HIV+ Persons. Journal of Water and Health 3:
173-184.
Zhang, L., Yang, W., Hubbard, A.E., Smith, M.T. 2005. Non-Random Aneuploidy of Chromosomes 1,
5, 6, 7, 8, 9, 11, 12 and 21 Induced by the Benzene Metabolites Hydroquinone and
Benzenetriol. Environmental and Molecular Mutagenesis 45:388-390.
Melov, S., Hubbard, A.E. 2004. Microarrays as a Tool to Investigate the Biology of Aging: A
Retrospective and a Look to the Future. Science of aging knowledge environment (SAGE KE)
– online Science: http://sageke.sciencemag.org/cgi/content/full/2004/42/re7.
Brindis, C.D., Geierstanger, S.P., Wilcox, N., McCarter, V., Hubbard, A.E. 2004. Evaluation of a Peer
Provider Reproductive Health Service Model for Adolescents. Perspectives on Sexual and
Reproductive Health 37,2: 85-91.
Nicas, M., Hubbard, A.E., Jones, R.M., Reingold, A.L. 2004. The Infectious Dose of Variola
(Smallpox) Virus. Applied Biosafety 9: 118-127.
Duramad, P., McMahon, C.W., Hubbard, A. Eskenazi, B., Holland, N. 2004. Flow Cytometric
Detection of Intracellular Th1/Th2 Cytokines Using Whole Blood: Validation of Immunologic
Biomarker for Use in Epidemiologic Studies. Cancer Epidemiology, Biomarkers & Prevention
13: 1452-58.
Spear, R., Zhong, B., Mao, Y., Hubbard, A., Remais, J., Dongchuan, Q. 2004. Spatial and Temporal
variability in schistosome cercarial Density Detected by Mouse Bioassays in Village Irrigation
Ditches in Sichuan, China. American Journal of Tropical Medicine and Hygiene 71 (5): 554-
557.
Dorsey, G., Gasasira, A..F., Machekano, R., Kamya, M.R., Staedke, S.G., Rosenthal, P.J., Hubbard, A.
2004. The Impact of Age, Temperature and Parasite Density on Treatment Outcomes from
Antimalarial Clinical Trials in Kampala, Uganda. American Journal of Tropical Medicine and
Hygiene 71 (5): 531-536.
Skibola, C.F., Forrest, M.S., Coppedé, F., Agana, L., Hubbard, A., Smith, M.T., Bracci, P.M. and
Holly, E.A. 2004. Polymorphisms and Haplotypes in Folate Metabolizing Genes and Risk of
non-Hodgkins Lymphoma. Blood 104 (7): 2155-2162.
Skibola, C.F., Holly E.A., Forrest, M.S., Hubbard, A., Bracci, P.M., Skibola. D.R., Hegedus, C.,
Smith, M.T. 2004. Body Mass Index, Leptin and Leptin Receptor Polymorphisms and Non-
Hodgkins Lymphoma. Cancer Epidemiology, Biomarkers and Prevention 13 (5): 779-786.

Pai, M., Flores, L., Hubbard, A., Riley, L., Colford, J. 2004. Nucleic Acid Amplification Tests in the
Diagnosis of Tuberculous Pleuritis: A Systematic Review and Meta-analysis. BMC Infectious
Diseases 4: Art. No. 6.
Spear, R.C., Seto, E., Liang, S., Birkner, M., Hubbard, A.E., Qui, D., Yang, C. Zhong, B., Xu, F., Gu,
X., Davis, G. 2004. Factors Influencing the Transmission of Schistosoma japonicum in the
Mountains of Sichuan Province of China. American Journal of Tropical Medicine and
Hygiene 70(1):48-56.
Pai, M., Flores, L., Pai, N., Hubbard, A., Riley, L., Colford, J. 2003. Diagnostic Accuracy of Nucleic
Acid Amplification Tests for Tuberculous Meningitis: A Systematic Review and Metaanalysis.
Lancet Infect Dis. 3: 633-43.
Eisenberg, J.N.S., Lewis, B.L., Porco, T.C., Hubbard, A.E., Colford, J.M. 2003. Bias Due to
Secondary Transmission in Estimation of Attributable Risks from Intervention Trials.
Epidemiology 14: 442-450.
Nicas, M., Hubbard, A.E. 2003. A Risk Analysis Approach to Selecting Respiratory Protection against
Airborn Pathogens Used for Bioterrorism. Am. Ind. Hyg. Assoc. J. 64(1): 95-101.
Cattamanchi, A., Kyabayinze, D., Hubbard, A., Rosenthal, P.J., Dorsey, G. 2003. Distinguishing
Recrudescence from Reinfection in a Longitudinal Antimalarial Drug Efficacy Study:
Comparison of Results Based on Genotyping of MSP-1, MSP-2, and GLURP. American
Journal of Tropical Medicine and Hygiene 68(2): 133-9.
Holland, N.T., Duramad, P., Rothman, N., Figgs, L.W., Blair, A., Hubbard, A.E., Smith, M.T. 2002.
Micronucleus Frequency and Proliferation in Human Lymphocytes after Exposure to Herbicide
2,4-dichlorophenoxyacetic Acid in vitro and in vivo. Mutation Research 521: 165-178.
Hubbard, A.E., Liang, S., Maszle, D., Qiu, D., Gu, X., Spear, R.C. 2002. Estimating the Distribution of
Worm Burden and Egg Excretion of Schistosoma japonica by Risk Group in Sichuan Province,
China. Parasitology 125: 221-231.
Goldberg, A.B., Cardenas, B.A., Hubbard, A.E., Darney, M.D. 2002. Post Abortion Depot
Medroxyprogesterone Acetate Continuation Rates: A Randomized Trial of Cyclic Estradiol.
Contraception 66(4): 215-20.
Nicas, M., Hubbard, A.E. 2002. A Risk Analysis for Pathogens with Low Infection Doses:
Application to Respirator Selection against Coccidioides immitis Spores. Risk Research
22(6):1153-63.
Spear, R.C, Hubbard, A.E., Liang, S., Seto, E. 2002. Disease Transmission Models for Public Health
Decision Making: Toward an Approach for Designing Intervention Strategies for
Schistosomiasis japonica. Env. Health Persp. 110(9): 907-915.
van der Laan, M.J., Hubbard, A.E., Robins, J.M. 2002. Locally Efficient Estimation of a Multivariate
Survival Function in Longitudinal Studies. J. Am. Stat. Assoc. 97 (458): 494-507
Skibola, C.F., Smith, M.T., Hubbard, A.E., et al. 2002. Polymorphisms in the Thymidylate Synthase
and Serine Hydrozymethyltransferase Genes and Risk of Adult Acute Lymphocytic Leukemia.
Blood 99 (10): 3786-3791.
Brookhart, M.A., Hubbard, A.E., van der Laan, Colford, J.M., Eisenberg, J.N.S. 2002. Statistical
Estimation of Parameters in a Disease Transmission Model: Analysis of a Cryptosporidium
Outbreak. Statistics in Medicine 21(23): 3627-3638.

Eisenberg, J.N.S., Wade, T.J., Hubbard, A.E., Abrams, D.I., Leiser, R.J., Charles, S., Vu, M., Saha, S.,
Wright, C.C., Levy, D.A., Jensen, P., Colford, J. 2002. Associations between Water-treatment
Methods and Diarrhoea in HIV-Positive Individuals. Epidemiol. Infect. 129 (2): 315-23.
Eisenberg, J.N.S., Wade, T.J., Charles, S., Vu, M., Hubbard, A.E., Wright, C.C., Levy, D., Jensen, P.,
Colford, J. 2002. Risk factors in HIV-Associated Diarrhoeal Disease: The Role of Drinking
Water, Medication and Immune Status. Epidemiol. Infect. 128 (1): 73-81.
Segal, M.R., Cummings, M.P., Hubbard, A.E. 2001. Relating Amino Acid Sequence to Phenotype:
Analysis of Peptide Binding Data. Biometrics 57(2): 632-643.
Smith, M.T., Zhang, L., Jeng, M., Wang, Y., Guo, W., Duramad, P., Hubbard, A.E , Hofstadler, G.,
Holland, N.T. 2000. Hydroquinone, a Benzene Metabolite, Increases the Level of Aneusomy
of Chromosomes 7 and 8 in Human CD34-positive Blood Progenitor Cells. Carcinogenesis 21,
8: 1485-1490.
Hubbard, A.E., van der Laan, M.J., Enanoria, W., Colford, J. 2000. Nonparametric Survival
Estimation when Death is Reported with Delay. Lifetime Data Analysis 6: 237-250.
Fenster, L., Waller, K., Chen, J., Hubbard, A.E., Windham, G.C., Elkin, E., Swan, S. 1999.
Psychological Stress in the Workplace and Menstrual Function. Am. J. Epidemiol. 149:127-
134.
Hubbard, A., van der Laan, M.J., Robins, J.M. 1999. Nonparametric Locally Efficient Estimation of
the Treatment Specific Survival Distributions with Right Censored Data and Covariates in
Observational Studies. In: Statistical Models in Epidemiology: The Environment and Clinical
Trials. Halloran, E. and Berry, D., eds. NY: Springer-Verlag, pp.135-178.
Colford, J.M., Tager, I, Byers, L.F., Ricci, P., Hubbard, A., Horner, R. 1999. Methods for Assessing
the Public Health Impact of Outflows from Combined Sewer Systems. Journal of the Air &
Waste Management Association. 49(4):454-462.
van der Laan, M.J., Hubbard, A.E. 1998. Locally Efficient Estimation of the Quality-Adjusted
Lifetime Distribution with Right-Censored Data and Covariates. Biometrics 55: 530-536.
van der Laan, M., Hubbard, A.E. 1998. Locally Efficient Estimation of the Survival Distribution with
Right Censored Data and Covariates when Collection of Data is Delayed. Biometrika 85, 4:
771-783.
van der Laan, M., Hubbard, A.E., 1997. Estimation with Interval Censored Data and Covariates.
Lifetime Data Analysis 3: 77-91.
Fenster, L., Hubbard, A.E., Swan, S.H., Windham, G.C., Waller, K., Hiatt, R.A., Benowitz, N. 1997.
Caffeinated Beverages, Decaffeinated Coffee and Spontaneous Abortion. Epidemiology 8: 515-
523.
Fenster, L., Hubbard, A.E., Windham, G., Waller, K., Swan, S. 1997. A Prospective Study of Work-
Related Physical Exertion and Spontaneous Abortion. Epidemiology 8: 66-74.
Fenster, L., Schaefer, C., Mathur, A., Hiatt, R., Pieper, C., Hubbard, A.E., Von Behren, J., Swan, S.
1995. Psychological Stress in the Workplace and Spontaneous Abortion. American Journal of
Epidemiology 142: 1176-83.
Hubbard, A.E., Gilinsky, N.L. 1992. Mass Extinction as Statistical Phenomena: An Examination of
the Evidence Using Chi-Square Tests and Bootstrapping. Paleobiology 18:148-160.

Selected Presentations
Hubbard, A.E. 2012. Semiparametric Estimation of Population Interventions. Invited talk to the
Siteman Cancer Center Washington University School of Medicine, St. Louis.
Hubbard, A.E. 2011. Developing Diagnostic Algorithms from Medical Data Prediction and Variable
Importance. Invited talk at Citris, Berkeley, CA.
Hubbard, A.E. 2010. The Curse of Dimensionality: Honestly Facing the Unknown in High
Dimensional Studies. Invited talk to the Center for Disease Control, Atlanta.
Hubbard, A.E. 2010. Semi-parametric models for the attributable risk: Targeted MLE and loss-based
estimation in public health. Invited talk in Neyman Seminar, UC Berkeley Statistics
Department.
Hubbard, A.E. 2009. Environmental Epidemiology: finding the key exposures in a haystack of
potentials. Invited talk in Environmental Health Division, Emory University.
Hubbard, A.E. 2008. Dealing with the curse of dimensionality in observational epidemiological
studies: causal inference methods and their limitations. Invited talk to the Robert Woods
Johnson Scholars, Health and Society Scholars Program. Sept, 2008.
Hubbard, A.E. 2008. Gene Expression Study Reveals Exercise Reverses Aging in Human Skeletal
Muscle. Invited talk at Spring 08 Research Symposium, School of Public Health, University of
California. February 28, 2008.
Hubbard, A.E. 2008. Causal Inference and The Curse of Dimensionality. Invited talk Society of
Epidemiological Research (SER) Annual Meeting, Chicago, June 2008.
Hubbard, A.E. 2008. Population Intervention Models and the Curse of Dimensionality. Invited talk at
Epidemiological Research Seminar Series, School of Public Health, University of Michigan,
Ann Arbor, MI, March 5, 2008.
Hubbard, A.E. 2006. Population Intervention Models. Invited talk at Friday Seminar Series, Division
of Epidemiology and Biostatistics, School of Public Health, UIC, Chicago, December 8, 2006.
Hubbard, A.E. 2006. A New Screening Algorithm for Multiple Risk Factor/Disease Association
Studies: Combining Variable Importance, the Conditional Permutation Distribution and
Multiple Testing Procedures. Invited talk at Biostatistics Seminar Series, Stanford University
Palo Alto, CA, April 27, 2006.
Hubbard, A.E. 2006. A New Screening Algorithm for Multiple Risk Factor/Disease Association
Studies: Combining Variable Importance, the Conditional Permutation Distribution and
Multiple Testing Procedures. Invited talk at Biostatistics Seminar Series, University of
California, San Francisco. March, 2006.
Hubbard, A.E. 2005. Population Intervention Models in Causal Inference. American Public Health
Association 133rd Annual Meeting, Philadelphia, Dec. 2005.
van der Laan, M., Hubbard, A. and Jewell, N. 2005. Estimation of Treatment Effects in Randomized
Trials with Noncompliance and a Binary Outcome. Joint Statistical Meeting, Minneapolis,
August, 2005.
Hubbard, A.E., Eisenberg, J. and Trostle, J. 2005. Applying data reduction methods borrowed from

ioinformatics to social network data from coastal Ecuador. Sunbelt XXV: International
Network for Social Network Analysis, Redondo Beach, CA, February 16-20, 2005.
Hubbard, A.E. 2004. Design and Analytical Issues in Microarray Experiments. Invited talk in premeeting
workshop I: Proteomics, Metabonomics and Genomics of Oxidative Stress. SFRBM'S
11th Annual Meeting, November 17-21, 2004.
Hubbard, A.E., Machekano, R. and Dorsey, G. 2004. Statistical methods to incorporate the inherent
ambiguity of molecular genotyping techniques used to distinguish malarial re-infection from
recrudescence. American Society of Tropical Medicine and Hygiene 53rd Annual Meeting
November 7 - November 11, 2004.
Hubbard, A.E. 2004. Design and Analytical Issues in Microarray Experiments. Invited talk at the Buck
Institute of Aging Research, Sept. 2004.
Pai, M., Flores, L.L., Hubbard, A., Riley, L.W.and Colford, J.M. 2003. Nucleic acid amplification tests
in the diagnosis of tuberculous pleuritis: a meta-analysis. CDHS/CTCA Spring 2003
Conference, April 24 & 25, 2003, Oakland, CA.
Pearl, M., Kharrazi, M., DeLorenze, G., Domdom, D., Caves, J., Marzullo, M. and Hubbard, A.E.
2003. Acertaining time to pregnancy among women obtaining clinical pregnancy confirmation.
SER Meeting, Atlanta, GA.
Heyman, M.B., Harmatz, P., Golden, D.W., Duramed, P., Bae, J., Cooper, J., Momi, R., Chen, C.,
Hubbard, A.E. and Holland, N.T. 2003. A longitudinal prospective study of pediatric patients
with Inflammatory Bowel Disease (IBD) using cytogenetic and immunological markers.
Gastroenterology 124(4) A515, Suppl. S.
M. Pai, Laura Flores, Nitika Pai, Michael McCulloch, A Hubbard, L. Riley & J. M. Colford. 2003.
Quality of studies evaluating the accuracy of nucleic acid amplification tests (NAAT) for
tuberculosis. National Conference on Laboratory Aspects of Tuberculosis.
M. Pai, L. Flores, N. Pai, A. Hubbard, L. W. Riley, J. M. Colford, Jr. 2003. Comparison of Diagnostic
Accuracy of Commercial and In-house Nucleic Acid Amplification Tests for Tuberculous
Meningi tis: a Meta-analysis. American Society for Microbiology 103rd General Meeting,
May 18 - 22, 2003, Washington, D.C.
Holland, N.T., Harmatz, P., Wu, Y., Bae, J., Golden, D.W., Cooper, J., Madden, J., Chen, C., Hubbard,
A.E. and Heyman, M.B. 2002. Chromosomal abnormalities in epithelial and blood cells of
children with two types of Inflammatory Bowel Disease (IBD) American Journal of Human
Genetics 71(4) 721, Suppl. S.
Hubbard, A. 2002. Some Statistical Methods for Microarray Analysis. Invited talk at Tsinghua
University, Beijing.
Henneman, T., van der Laan, M. and Hubbard, A. 2001. Estimating Causal Parameters in Marginal
Structural Models with Unmeasured Confounders Using Instrumental Variables. ASA Joint
Meeting, Atlanta.
Hubbard, A.E., Liang, S., Maszle, D., Qiu, D., Gu, X., Spear, R.C. 2001. Estimating the distribution of
worm burden and egg excretion of Schistosomiasis japonica by risk group in the Sichuan
Province, China. Presented at the International Schistosomiasis Conference in Shanghai, July
2001.
Hubbard, A.E. Statistical uncertainty in global burden of disease (GBD) estimates. WHO workshop
to generate guidelines for estimating burden of disease associated with environmental risk
factors. Buffalo, New York, August, 2000.

Holland, N.T., Schumacher, L., Gunn, L., Hubbard, A.E., Nguyen, L., Golden, D., Duramed, P. and
Smith, M.T. 2000. Non-invasive analysis in children: Micronuclei in exfoliated buccal and
urothelial cells. American J. of Human Genetics, 67(4): 146.
Hubbard, A.E. and Hubbard, S.S 1999. Estimation of Petrophysical Relationships and Measurement
Length Scales using Multi-Scaled Field Data. AGU National Meeting, San Francisco, CA.
Hubbard, A.E. 1999. How to get the most out of observational data. Invited presentation at
International Perinatal Meeting, San Francisco, CA.
Jacobs, D.K. and Hubbard, A.E. 1998. Quantifying the influence of diversity on origination.
Geological Society of America Abstracts 30(7).
Hubbard, A.E. and Jacobs, D.K. 1998. A hierarchical analysis of the influence of diversity on
origination in the fossil record. Geological Society of America Abstracts 30(5).
Fenster, L., Hubbard, A.E., Swan, S.H., Windham, G.C., Waller, K., Hiatt, R.A., and Benowitz, N.
1996. Caffeinated beverages, decaffeinated coffee and spontaneous abortion. Society for
Epidemiological Research (Boston).
Jacobs, D.K. and Hubbard, A.E. 1991. What's different about Arthropods? Intrinsic and extrinsic
constraint on body-plan evolution. Geological Society of America Abstracts (North Central
Section) 23, page 19.
Bambach, R.K. and Hubbard, A.E. 1990. The anatomy of episodes of faunal turnover in the marine
biosphere. Geological Society of America Abstracts 22(2), page 3.
Bambach, R.K., Hubbard, A.E. and Bennington, J.B. 1990, Ecosystem stability at different temporal
scales. International Congress on Systematic and Evolutionary Biology IV. Abstracts page 7.
Gilinsky, N.L. and Hubbard, A.E. 1990. Mass extinction's in relation to characteristic extinction
intensities of families within orders. International Congress on Systematic and Evolutionary
Biology IV. Abstracts page 111.