Bioinformatics Custom Computing

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• bioinformatics – “bioinformatics is the application of computer science and information technology to the field of biology” [Wikipedia] – works on genome information • many applications – understanding of biologic processes, e.g. interaction of genes – protein structure prediction – drug discovery and design • computationally intensive methods – data mining – pattern recognition – machine learning – visualization definition, image: Wikipedia What is <strong>Bioinformatics</strong>?
Revolutionary Progress in Genome Sequencing • 2003: Human Genome Project – 3’000 mega base pairs (Mbp) sequenced – 13 years / 300 Mio US$ • 2007: introduction of next generation sequencers – James Watson (454 Life sciences) – 2 month / 2 Mio US$ • 2011: duration and cost greatly reduced – ~14 days / 30’000 US$ • cost of sequencers also reduced, available at many labs data, images: A. Goesmann Uni Bielefeld, genome.gov, 454 Life Sciences
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