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<strong>DACC</strong> NEWS<br />

Wow how time has flown<br />

by since our Spring Meeting<br />

that was held early in May at<br />

Roche in Nutley New Jersey!<br />

The meeting was very well<br />

attended, and in this economy<br />

that says a lot about the<br />

excellence of the scientific<br />

program. Rosemary Nicklaus<br />

with support from Barbara<br />

Litzenberger did an exceptional<br />

job bringing together complementary<br />

speakers to educate our membership about<br />

emerging research in the pathogenesis, detection<br />

and therapeutic options related to autoimmune<br />

diseases and inflammatory states. The meeting<br />

was launched by Diagen Xu of Roche who provided<br />

an overview the biologic principles underlying<br />

inflammatory dysfunction and described<br />

current and emerging therapeutic approaches,<br />

challenges and opportunities <strong>for</strong><br />

several inflammatory disorders. Provocative<br />

discussions followed, lead by Tom Misko of<br />

Division of Animal <strong>Clinical</strong> Chemistry<br />

Volume 26, Number 2 June <strong>2010</strong><br />

<strong>DACC</strong> Annual Meeting<br />

July 25-29 Anaheim, CA<br />

Message from the Chair<br />

In This Issue:<br />

Pg. 4 <strong>Summer</strong> Meeting Activities<br />

Pg. 5 Annual Symposium Abstract<br />

Pg. 6 Peter Eckersall Recognized <strong>for</strong><br />

Outstanding Contributions to<br />

Animal <strong>Clinical</strong> Chemistry<br />

Pg. 7 <strong>DACC</strong> Relevant Poster Titles<br />

Pg. 9 Photos from the Spring Meeting<br />

Pfizer Global Research & Development, St Louis,<br />

regarding nitrative damage to proteins related to<br />

nitrotyrosine <strong>for</strong>mation and the clinical translatability<br />

of biomarkers in rodent models of rheumatoid<br />

arthritis. Chris Stevenson of Roche also described<br />

relevant animal models <strong>for</strong> asthma and chronic<br />

obstructive pulmonary disease illustrating how in<br />

vivo models continue to be vital <strong>for</strong> furthering the<br />

understanding of disease pathogenesis and <strong>for</strong><br />

developing new therapies. Calvert Louden of<br />

Johnson & Johnson Pharmaceutical Research<br />

and Development propagated the learning<br />

experience with a nice talk broadening our<br />

scope of translatable biomarkers used to assess<br />

systemic inflammatory response syn-


drome. The typical after lunch audience drowsiness,<br />

that befalls some speakers, was not a problem<br />

<strong>for</strong> the entertaining delivery and important in<strong>for</strong>mation<br />

presented by Jon Klover of Covidien<br />

regarding the predictive merits and variable response<br />

of acute phase biomarkers across species<br />

and strains. If the attendees of the Spring Meeting<br />

were not infected with enthusiasm about the science<br />

and value of complement assays by Patsy<br />

Giclas of National Jewish Health, they didn’t have<br />

a pulse. She closed our symposium with pizzazz!<br />

The next opportunity <strong>DACC</strong> members have to get<br />

together is rapidly approaching at the end of July<br />

in Anaheim Cali<strong>for</strong>nia. If you haven’t already done<br />

so, make your travel and registration arrangements<br />

NOW! You don’t want to miss this exciting<br />

week of events in So Cal. On Monday evening<br />

July 26 Siemens Healthcare Diagnostics is continuing<br />

its long running dedication to scientists in<br />

our industry by once again sponsoring the<br />

<strong>DACC</strong>’s Award <strong>for</strong> Outstanding Contributions to<br />

Animal <strong>Clinical</strong> Chemistry, where you and your<br />

partner are invited to the Tortilla Jo’s restaurant at<br />

6:30 pm <strong>for</strong> the <strong>DACC</strong> Mixer and Award Presentation<br />

Reception. On Tuesday morning, July 28, seriously<br />

consider joining us in the <strong>DACC</strong> Executive<br />

Business Meeting at 8:30-10:30am (Hilton Anaheim<br />

Hotel -Capistrano A). Another Tuesday<br />

must-attend-event is our division’s General Business<br />

Meeting and Lunch & Learn session at<br />

12:30-3:30pm (Hilton Anaheim Hotel - Manhattan<br />

Room). After a free lunch we will conduct several<br />

simultaneous in<strong>for</strong>mal round table discussions addressing<br />

our common conundrums, challenges,<br />

approaches, and triumphs. Many relevant and<br />

timely topics will be touched upon and each will be<br />

re-capped <strong>for</strong> the benefit of the greater group.<br />

There will be no charge <strong>for</strong> this novel “LISTSERV<br />

LIVE!” networking event. Whoever said there is no<br />

such thing as a free lunch was wrong, because a<br />

tasty array of delectable victuals will be provided<br />

<strong>for</strong> all who attend the General Business Meeting<br />

and Lunch & Learn session. If you need another<br />

reason to support your request to travel to the Annual<br />

Meeting, this session will provide the type of<br />

in<strong>for</strong>mation that is critical to benchmark and harmonize<br />

operations of preclinical research and<br />

GLP laboratories. On Wednesday July 28, 2:30-<br />

5:30pm, the <strong>DACC</strong> has put together an official<br />

AACC annual meeting symposium in conjunction<br />

with the AACC’s newest <strong>Clinical</strong> Transitional<br />

Science division which specifically caters to interests<br />

in our industry titled “From Bench to Bed-<br />

2<br />

side: <strong>Clinical</strong> Translational Science”. We’d love to<br />

see you in Anaheim!<br />

Recently the <strong>DACC</strong> Secretary, Tracey Boone, resigned<br />

her post to pursue software/middleware<br />

related career opportunities outside the preclinical<br />

industry. We thank her <strong>for</strong> her contribution to the<br />

<strong>DACC</strong> and wish her well. It was heartwarming and<br />

reassuring about the caliber of our membership<br />

that we had several respected scientists, who are<br />

just as busy as the rest of us, step <strong>for</strong>ward to fill<br />

the acute need of our all volunteer division. Compliant<br />

with <strong>DACC</strong> ByLaws, the Executive Committee<br />

appointed a replacement Secretary to serve<br />

out the remainder of the vacated office. The appointment<br />

went to Renée Pearson, MS, DVM, Diplomate,<br />

ACVP (<strong>Clinical</strong> Pathology) of Pearson<br />

Consulting, LLC. The <strong>DACC</strong> is very appreciative<br />

of Renee’s willingness, and those of the other volunteers,<br />

to get involved!<br />

Membership involvement is up this year as evidenced<br />

by the record high attendance at the open<br />

Executive Committee meeting held at the Spring<br />

Meeting. In addition to elected officers and committee<br />

members, several member guests sat in<br />

and contributed to the division’s business and<br />

plans <strong>for</strong> the future. This show of interest and support<br />

was exceptional! Don’t miss the action, the<br />

satisfaction of participation, and the promise of<br />

building strong network bonds. Join us in assuring<br />

the continuing legacy of excellent programs <strong>for</strong><br />

your colleagues and the mission of the <strong>DACC</strong>.<br />

Catch the Multispecies Wave this summer on the<br />

Southern Cali<strong>for</strong>nia coast!<br />

� ~Mike<br />

Division of Animal<br />

<strong>Clinical</strong> Chemistry<br />

And<br />

<strong>Clinical</strong> Transitional Science<br />

Division Symposium<br />

From Bench to Bedside:<br />

<strong>Clinical</strong><br />

Translational Science<br />

Wednesday, July 28, 2:30pm – 5:30pm


A<br />

BIG<br />

<strong>DACC</strong><br />

THANKS!<br />

To:<br />

Roche<br />

For Hosting the <strong>2010</strong> <strong>DACC</strong> Spring<br />

Meeting at Their Facility and <strong>for</strong><br />

Providing Printed Handouts, Breakfast<br />

and Lunch<br />

To:<br />

Siemens Healthcare<br />

Diagnostics<br />

For Organizing and Hosting the<br />

<strong>2010</strong> Spring Multispecies Users<br />

Group Meeting and <strong>for</strong> Providing<br />

Printed Handouts, Breakfast and<br />

Lunch<br />

To:<br />

Sysmex, Ltd.<br />

For Hosting the <strong>DACC</strong> Mixer/Buffet<br />

Dinner and Meet the Speakers<br />

Reception at the <strong>2010</strong> Spring<br />

Meeting<br />

3<br />

<strong>DACC</strong> Supporters<br />

SUSTAINING SPONSORS<br />

Siemens Healthcare Diagnostics<br />

Benefactors<br />

Hoffmann-LaRoche, Inc<br />

Merck & Co., Inc.<br />

Novartis Pharmaceuticals Corporation<br />

Pfizer Global Research and Development<br />

Patrons<br />

Allergan, Inc.<br />

Beckman Coulter<br />

GlaxoSmithKline<br />

Merck Research Laboratories<br />

Sysmex America, Inc.<br />

Contributors<br />

Kay Criswell – Pfizer Global R&D<br />

Friends<br />

John Allinson - ICON Devel Sol’ns<br />

Tracey Boone - Pfizer Global R&D<br />

Bruce D. Car - Bristol-Myers Squibb Co.<br />

Daniela Ennulat - GlaxoSmithKline<br />

Warren Glaab - Merck & Co., Inc.<br />

Elizabeth Hausner, DVM, DABT, DABVT, -<br />

FDA Div Cardiovascular & Renal Drug<br />

Jon Kimball - Potter-Hawkins Group<br />

Jon Klover - Covidien<br />

Calvert Louden, PhD - Johnson &<br />

Johnson Pharm Research & Development<br />

Pankaj Oberoi, PhD - Meso Scale<br />

Discovery<br />

Marielle Odin - Hoffmann-LaRoche<br />

Ralph Parchment, PhD - National Cancer<br />

Institute<br />

Shelli Schomaker - Pfizer Global Research<br />

& Development<br />

Eric Schultz - Lilly Research Laboratories<br />

Frank Sistare, PhD - Merck & Co., Inc<br />

Chris Stevenson, PhD - Hoffmann-LaRoche<br />

Diagen Xu - Hoffmann-LaRoche<br />

David Zelmanovic - LabThroughPut, Inc


�� Division of Animal <strong>Clinical</strong> Chemistry ��<br />

<strong>2010</strong> AACC Annual Meeting Activities<br />

Monday – July 26<br />

<strong>DACC</strong> Reception <strong>for</strong> Outstanding Contributions to Animal <strong>Clinical</strong> Chemistry<br />

Award Presentation and Mixer<br />

Tortilla Jo’s , Downtown Disney - Watch <strong>for</strong> details from the <strong>DACC</strong> Listserver<br />

Hosted again by Siemens Healthcare Diagnostics 6:30pm<br />

Tuesday – July 27<br />

Animal Division Posters Session 01<br />

See Animal Poster Listings (A1 - A19) 10:00am – 12:30pm<br />

<strong>DACC</strong> Executive Committee Meeting<br />

Hilton Anaheim Hotel, Capistrano A Conference Room 8:00am – 10:30am<br />

Open to All Members! Come Join in the Planning of <strong>DACC</strong> Activities!<br />

General Business Meeting and Lunch and Learn<br />

CONUNDRUMS & TRIUMPHS<br />

Hilton Anaheim Hotel, Manhattan Room 12:30pm – 3:30pm<br />

Wednesday – July 28<br />

SYMPOSIA<br />

From Bench to Bedside: <strong>Clinical</strong> Translational Science<br />

2:30pm – 5:30pm<br />

<strong>Clinical</strong> Translational Science Awards(CTSAs), Core Resources in the Age of Translation<br />

Anthony Hayward, MD, PhD, National Center <strong>for</strong> Research Resources, Bethesda, MD<br />

Success Story of <strong>Clinical</strong> Translation from Bench to Bedside: Cystic Fibrosis<br />

Frank Accurso, MD, University of Colorado Denver, Aurora<br />

Translatability of New Biomarkers to <strong>Clinical</strong> Use: Scientific Criteria <strong>for</strong> Success<br />

Lawrence Oliver, PhD, DABCC, NACB, Mayo Clinic, Rochester, MN<br />

Humanized Animal Models: An Emerging Approach <strong>for</strong> Biomarker Development and<br />

Translation<br />

Jirl Aubredecht, PharmD, PhD, Pfizer, Inc., Groton, CT<br />

4


Peter David Eckersall, BSc, MBA, PhD, FRCPath<br />

Named to Receive <strong>2010</strong> <strong>DACC</strong> Award <strong>for</strong><br />

Outstanding Contributions to Animal <strong>Clinical</strong> Chemistry<br />

The <strong>American</strong> <strong>Association</strong> <strong>for</strong> <strong>Clinical</strong> Chemistry<br />

(AACC) Division of Animal <strong>Clinical</strong> Chemistry (<strong>DACC</strong>)<br />

is proud to announce that Peter David Eckersall,<br />

BSc, MBA, PhD, FRCPath has been named the<br />

recipient of the <strong>2010</strong> Award <strong>for</strong> Outstanding Contributions<br />

to Animal <strong>Clinical</strong> Chemistry. This<br />

award, sponsored by Siemens Healthcare Diagnostics,<br />

is awarded to a recipient that has per<strong>for</strong>med<br />

outstanding work in the discipline of animal clinical<br />

laboratory medicine.<br />

Dr. Eckersall has been an innovator in developing<br />

and exploiting a range of clinical biochemistry applications,<br />

particularly acute phase proteins, proteomics<br />

and inflammatory biomarker characterization<br />

of human and animal disease from pathophysiology<br />

to clinical applications. His impact has been<br />

notable in a continuing legacy of education and<br />

teaching in academia, and in numerous workshops<br />

and symposia, in elucidating mechanisms of dis-<br />

5<br />

ease and inflammation in animals/models, as well as<br />

influencing advances in biomarker development;<br />

these contributions include, among many others, Creactive<br />

protein, haptoglobin, serum amyloid A, alkaline<br />

phosphatase isoenzyme methodologies, a1acid<br />

glycoprotein, a2-macroglobulin, tumor necrosis<br />

factor receptor (TNF-R2), and thyroid function and<br />

endocrine assessment in animals.<br />

Dr. Peter David Eckersall is presently Professor of<br />

Veterinary Biochemistry, University of Glasgow Veterinary<br />

School, and Chief Scientific Officer and a Director<br />

of ReactivLab Ltd, a company focused on the<br />

development of acute phase protein tests <strong>for</strong> use in<br />

animal clinical chemistry. In addition, he has initiated<br />

a program to establish a European group <strong>for</strong><br />

the use of proteomics in domestic animal research<br />

and diagnosis, and is also engaged in an international<br />

collaboration setting up a link between Glasgow<br />

Veterinary School and the Veterinary College,<br />

Universiti Putra Malaysia <strong>for</strong> the development<br />

of clinical chemistry and clinical pathology in SE<br />

Asia.<br />

Dr. Eckersall obtained his BS with honors from the<br />

University of Liverpool, an MBA at the University of<br />

Glasgow, and PhD in Biochemistry from the University<br />

of Edinburgh. He became a member of the<br />

Royal College of Pathologists in 1993, and was<br />

elected as a Fellow of the RCPath in 1998. David<br />

Eckersall joined the faculty of the University of Glasgow<br />

Veterinary School in 1980, and has been Professor<br />

of Veterinary Biochemistry since 2002. During<br />

his tenure he has mentored more than eighteen veterinary<br />

postgraduate candidates <strong>for</strong> MVM or PhD<br />

degrees.<br />

Dr. Eckersall has authored or co-authored over 120<br />

peer-reviewed manuscripts, a text book [Animal<br />

<strong>Clinical</strong> Biochemistry, The Future] and 8 book chapters<br />

[most recently in 2008: Eckersall, P.D. (2008)<br />

Proteins, Proteomics and Dysproteinemias, in <strong>Clinical</strong><br />

Biochemistry of Domestic Animals]. He has been a<br />

frequent invited speaker and symposium organizer<br />

<strong>for</strong> over 130 national and international meetings<br />

on topics of proteomics and acute phase protein<br />

biomarkers of inflammation, protein analysis and


Outstanding Contributions to Animal <strong>Clinical</strong> Chemistry, continued...<br />

veterinary diagnosis, and immunogenomics. His research<br />

activities have been highly recognized in the<br />

arenas of proteins, proteomics and dysproteinemias,<br />

cytokines and the acute phase response in posttreatment<br />

reactive encephalopathy following infection,<br />

the use of CRP, haptoglobin, and serum amyloid<br />

A as markers of infection and inflammation, discrimination<br />

between acute and chronic inflammation,<br />

and species differences in the acute phase response<br />

in companion, livestock and laboratory animals.<br />

World-wide interest in the investigation of acute<br />

phase protein in animals has been stimulated by his<br />

research and a University of Glasgow spinout company<br />

ReactivLab Ltd was <strong>for</strong>med (2007) to commercialize<br />

his research.<br />

David Eckersall is also the Leader of a Veterinary<br />

Gene & Protein Group, which is engaged in the application<br />

of molecular genetics and protein analysis<br />

to investigate areas in animal health. The laboratory<br />

has been established as the leading British center<br />

<strong>for</strong> research in animal clinical biochemistry with<br />

funding of £10 million and the group has published<br />

over 300 papers.<br />

Dr. Eckersall has had many honors and distinctions;<br />

he is a Fellow of the Royal College of Pathologists<br />

(FRCPath), serves as an Examiner <strong>for</strong> the MRCPath<br />

in Veterinary <strong>Clinical</strong> Pathology, is a member of the<br />

European Society <strong>for</strong> Veterinary <strong>Clinical</strong> Pathology,<br />

the Animal <strong>Clinical</strong> Chemistry <strong>Association</strong>, the Comparative<br />

<strong>Clinical</strong> Pathology <strong>Association</strong>, and the International<br />

Society <strong>for</strong> Animal <strong>Clinical</strong> Pathology, of<br />

which he was President during1996-1998. He has<br />

cultivated numerous international collaborations with<br />

the Utrecht Veterinary School and seven other laboratories<br />

in an European Union Concerted Action: Ontario<br />

Veterinary College; Atlantic Veterinary College;<br />

School of Veterinary Medicine, Davis Cali<strong>for</strong>nia; International<br />

Laboratory <strong>for</strong> Livestock Research, Nairobi,<br />

Kenya; Institute <strong>for</strong> Animal Health, Compton;<br />

the Moredun Research Institute; and the Faculty of<br />

Veterinary Medicine, University of Perideniya, Sri<br />

Lanka. In 2008, Dr. Eckersall was awarded the distinguished<br />

Heiner Sommer Prize <strong>for</strong> Lifetime Contributions<br />

to Animal <strong>Clinical</strong> Biochemistry by the<br />

International Society <strong>for</strong> Animal <strong>Clinical</strong> Pathology.<br />

6<br />

It is with great pleasure that the Executive and<br />

Awards Committees of the AACC Division of Animal<br />

<strong>Clinical</strong> Chemistry recognize Dr. Peter David Eckersall,<br />

BSc, MBA, PhD, FRCPath as the <strong>2010</strong> recipient<br />

of the <strong>DACC</strong> Award <strong>for</strong> Outstanding Contributions to<br />

Animal <strong>Clinical</strong> Chemistry. The award will be presented<br />

at the <strong>DACC</strong> Reception, sponsored by Siemens<br />

Healthcare Diagnostics, during the <strong>2010</strong> Annual<br />

AACC Meeting in Anaheim, CA.<br />

<strong>DACC</strong> Reception <strong>for</strong> Outstanding<br />

Contributions to Animal <strong>Clinical</strong><br />

Chemistry Award Presentation<br />

The <strong>DACC</strong> Reception and Presentation of our<br />

division’s Award <strong>for</strong> Outstanding Contributions<br />

to Animal <strong>Clinical</strong> Chemistry will be held on<br />

Monday evening July 26 th beginning at 6:30<br />

pm in Downtown Disney at<br />

Tortilla Jo's,<br />

1510 DISNEYLAND DR., ANAHEIM 92802<br />

We gratefully acknowledge that this annual<br />

event is again sponsored by the generous support<br />

of<br />

Siemens Healthcare Diagnostics.


<strong>2010</strong> <strong>DACC</strong>/AACC POSTER SESSION<br />

<strong>2010</strong> <strong>DACC</strong>/AACC POSTER SESSION<br />

Session: 01, Tuesday, July 27, 10:00am – 12:30pm<br />

Please visit the posters at this year's Annual Meeting. The abstracts are the first ones listed in the Annual<br />

Meeting Supplement (A1 – A19), so they are easy to find in the program and will be easy to find on the exhibit<br />

floor. The diversity of these posters will provide valuable in<strong>for</strong>mation on a host of practical issues that<br />

may affect your daily work and provide guidance on potential new directions <strong>for</strong> your laboratory.<br />

<strong>2010</strong> <strong>DACC</strong> Posters<br />

Submitted <strong>for</strong> <strong>DACC</strong> Travel Award Competition<br />

Tuesday, July 27, 10:00 am – 12:30 pm<br />

Session 1 Animal <strong>Clinical</strong> Chemistry<br />

A-01 Toxicity Assessment of the Aqueous Extract of<br />

Calotropis Procera in Rabbits.<br />

J. D. Mbako. University of Yaounde I, Yaounde, Cameroon<br />

A-02 RNase L is involved in hematopoiesis and iron retention.<br />

X. Yi, A. Zhou. Cleveland State University, Cleveland, OH<br />

A-03 The effects of nitric oxide and asymmetric dimethylarginine<br />

in the rat endometriosis model.<br />

T. Cayci, E. O. Akgul, Y. Gulcan Kurt, T. S. Ceyhan, I. Aydin, O.<br />

Onguru, H. Yaman, E. Cakir, C. Bilgi, K. M. Erbil. Gulhane Military<br />

Medical Academy, Ankara, Turkey<br />

A-04 Pentraxin 3 as a Potential Biomarker of Acetaminophen-Induced<br />

Liver Injury.<br />

E. Cakir, E. O. Akgul, I. Aydin, O. Onguru, T. Cayci, Y. Gulcan<br />

Kurt, M. Agilli, F. N. Aydin, M. Gulec, N. Ersoz, T. Turker, H.<br />

Yaman, C. Bilgi, K. M. Erbil. Gulhane Military Medical Academy,<br />

Ankara, Turkey,<br />

A-05 The <strong>Association</strong> between Neopterin and Acetaminophen-Induced<br />

Nephrotoxicity.<br />

E. Cakir, E. O. Akgul, I. Aydin, T. Cayci, Y. Gulcan Kurt, O.<br />

Onguru, F. N. Aydin, M. Agilli, H. Yaman, N. Ersoz, A. Guven, T.<br />

Turker, C. Bilgi, K. M. Erbil. Gulhane Military Medical Academy,<br />

Ankara, Turkey,<br />

A-06 Measurement of TS-131, a New Monopyridinium<br />

Oxime, by High Per<strong>for</strong>mance Liquid Chromatography in Rat<br />

Plasma Samples. Z. I. Kunak 1 , E. O. Akgul 1 , H. Yaren 1 , T. Cayci<br />

1 , Y. Gulcan Kurt 1 , I. Aydin 1 , H. Yaman 1 , L. Kenar 1 , T. Subasi 2 ,<br />

E. Cakir 1 , E. Macit 1 , A. S. Demir 2 , K. M. Erbil 1 , J. Z. Karasova 3 .<br />

1 Gulhane Military Medical Academy, Ankara, Turkey, 2 Middle<br />

East Technical University, Ankara, Turkey, 3 Faculty of Military<br />

Health Sciences, Hradec Kralove, Czech Republic<br />

A-07 Efficacy of Hyperbaric Oxygen Therapy and S-<br />

Methylisothiourea in Experimental Acute Necrotizing Pancreatitis.<br />

O. Altinel, N. Ersoz, B. Uysal, M. Ozturk, T. Cayci, B.<br />

Kurt, I. H. Ozerhan, Y. Gulcan Kurt, H. Yaman, A. Guven, A.<br />

Korkmaz, M. Yasar. Gulhane Military Med Acad, Ankara, Turkey<br />

A-08 Cardioprotective activity of Terminalia arjuna in<br />

Isoproterenol induced Myocardial ischemia in rats. S. K.<br />

Shukla, S. Dwivedi, U. R. Singh, S. B. Sharma. University<br />

college of medical sciences and GTB Hospital, Delhi, India,<br />

7<br />

A-09 Evaluation of Species Specific Calibrations <strong>for</strong><br />

Measuring Albumin in Urine of Dogs and Monkeys using an<br />

Automated Human Immunoturbidometric Assay. D. F. Adams,<br />

K. M. Lynch, T. S. Sellers, D. Ennulat. GlaxoSmithKline,<br />

King of Prussia, PA<br />

A-10 Effect of Vortexing Blood on In Vitro Hemolysis<br />

Assay Results.<br />

D.W. Sprenger, H. L. Jordan. GlaxoSmithKline, Research Triangle<br />

Park, NC<br />

A-11 Effects of phytic acid and exercise on some serum<br />

analytes in rats orally exposed to diets supplemented with<br />

cadmium. T. Daley, S. Omoregie, V. Wright, F. Omoruyi. Northern<br />

Caribbean University, Mandeville, Jamaica<br />

A-12 Effect of sulfite on antioxidant enzymes and lipid<br />

peroxidation in normal and sulfite oxidase-deficient rat<br />

erythrocytes. O. Ozturk 1 , S. Oktar 2 , M. Aydin 3 , V. Kuçukatay 4 ,<br />

N. Yilmaz 1 , Z. Yonden 1 , S. Sogut 1 . 1 Mustafa Kemal University,<br />

Faculty of Medicine, Department of Biochemistry, Hatay, Turkey,<br />

2 Mustafa Kemal University, Faculty of Medicine, Department<br />

of Pharmacology, Hatay, Turkey, 3 Mustafa Kemal University,<br />

Faculty of Medicine, Department of Physiology, Hatay, Turkey,<br />

4 Pamukkale University, Faculty of Medicine, Department of<br />

Physiology, Denizli, Turkey<br />

A-13 Evaluation of an Electrochemiluminescent Immunoassay<br />

<strong>for</strong> Measurement of Insulin in Rat Plasma. R.<br />

McGeary, T. Sellers, D. Ennulat. GlaxoSmithKline, King of Prussia,<br />

PA<br />

A-14 Apoptozis after acute spinal cord injury in rats and<br />

the effect of Erythropoietin(EPO).<br />

Y. E. Doventas 1 , S. Yigit 1 , M. Koldas 1 , B. Ozdemir 2 . 1 Haseki<br />

Edu.and Res.Hospital,<strong>Clinical</strong> Biochemistry, Istanbul, Turkey,<br />

2 Haseki Edu.and Res.Hospital,Neurosurgery, Istanbul, Turkey<br />

A-15 Lateral flow immunochromatographic assay using<br />

europium chelate-loaded silica nanoparticle labels <strong>for</strong><br />

highly sensitive detection of chloramphenicol. W. Yang, X.<br />

Xia, H. Zhang, Y. Xu, Q. LI. XMU, Xiamen, China<br />

A-16 Fructosamine Assay <strong>for</strong> the Veterinary Laboratory.<br />

L. Leon. Catachem Inc., Bridgeport, CT<br />

A-17 The Determination of Enzygnost Thrombin Anti-<br />

Thrombin III Complex in Pig Citrated Plasma to Support<br />

Pre-<strong>Clinical</strong> Toxicology Studies. C. Starks, B. Litzenberger,<br />

M. Genato, J. Dharmadhikari, C. McDonough. Huntingdon Life<br />

Sciences, East Millstone, NJ<br />

A-18 Evaluation of newly developed ELISAs <strong>for</strong> rat,<br />

mouse, dog and pig NGAL.<br />

K. Bangert, J. O. Eriksen, L. O. Uttenthal. BioPorto Diagnostics<br />

A/S, Gentofte, Denmark


A-19 The Effect of Chronic Hypoxia and Carbon Monoxide<br />

on Oxidative Stress in Rat Vascular Tissues. J. Kalra 1 , H.<br />

Neufeld 2 , C. Vandier 3 , R. Wang 4 . 1 Royal University Hospital,<br />

Saskatoon, SK, Canada, 2 University of Saskatchewan, Saskatoon,<br />

SK, Canada, 3 Universite Francois Rabelais de Tours,<br />

Tours, France, 4 Lakehead University, Thunder Bay, ON, Canada<br />

Additional Posters of Interest to <strong>DACC</strong><br />

Submitted <strong>for</strong> <strong>DACC</strong> Travel Award Competition<br />

Tuesday, July 27, 2:00 pm – 4:30 pm<br />

Session 6 Endocrinology/Hormones<br />

B-40 The Measurement of Salivary Testosterone by<br />

Mass Spectrometry and Comparison to Paired Free and<br />

Bio-Available Testosterone Samples. J. Orrock, R. Taylor, S.<br />

Grebe, R. Singh. Mayo Clinic, Rochester, MN<br />

Wednesday, July 28, 10:00 am – 12:30 pm<br />

Session 10 <strong>Clinical</strong> Studies/Outcomes<br />

C-13 Use of clinical biology techniques in clinical practice:<br />

injections of platelet-rich plasma to heal tendon. J.<br />

Kaux1, C. Le Goff2, P. Drion1, F. Pascon1, V. Libertiaux1, A.<br />

Gothot1, S.<br />

Cescotto1, D. Jean-Olivier1, M. Rickert3, J. Crielaard1. 1University<br />

of Liège, Liège, Belgium, 2University Hospital of Liège,<br />

Liège, Belgium, 3University of Heidelberg, Heidelberg, Germany<br />

C-14 New use of VEGF in therapeutics: application in<br />

tendon lesions.<br />

J. Kaux1, L. Caroline2, P. Drion1, V. Libertiaux1, F. Pascon1, A.<br />

Colige1, L. Charles1, B. Nusgens1, S. Cescotto1, J. Defraigne1,<br />

M. Rickert3, J. Crielaard1. University of Liège, Liège, Belgium,<br />

2University Hospital of Liège, Liège, Belgium, 3University of<br />

Heidelberg, Heidelberg, Germany, Chang Gung University,<br />

Taipei, Taiwan<br />

Session 13 Nutrition/Trace Metals/Vitamins<br />

C-130 Nutritional implications and flour functionality of<br />

defatted wheat germ.<br />

M. U. Arshad1, F. M. Anjum2, T. Zahoor3, H. Nawaz2. 1University<br />

of Sargodha, Sargodha, Pakistan, 2University of Agriculture,<br />

Faisalabad, Pakistan, 3Washington State University, Pullman,<br />

WA<br />

C-148 Analysis of serum tryptophan, kynurenine and<br />

kynurenic acid by HPLC.<br />

Y. Z. Xiang, G. A. Tang, P. Y. Ren, X. Q. Zhou, B. X. Luo. Department<br />

of <strong>Clinical</strong> Laboratory, Second Xiangya Hospital,<br />

Central South University, Changsha, P.R., changsha,<br />

China<br />

Thursday, July 29, 9:00 am – 12:00 pm<br />

Session 21 TDM/Toxicology/DAU<br />

E-81 Anti cataract effect of active principle purified<br />

from fruit-pulp of Eugenia jambolana in galactose fed<br />

rats. R. S. Tanwar, S. B. Sharma, V. P. Gupta. University<br />

College of Medical Sciences, University Of Delhi, Delhi,<br />

India<br />

8<br />

A Call To Service<br />

The <strong>DACC</strong> Needs YOU!<br />

Candidates are needed <strong>for</strong>:<br />

� Chair-Elect<br />

� Treasurer<br />

� Nominating Committee<br />

Member<br />

The nominating committee needs to<br />

present candidates, <strong>for</strong> the above roles,<br />

to the Executive Committee at the AACC<br />

Annual Meeting in Anaheim this July.<br />

This is an excellent opportunity <strong>for</strong><br />

members to become more involved in<br />

the division and to <strong>for</strong>m the kind of lasting<br />

professional relationships that are<br />

so valuable <strong>for</strong> professional growth.<br />

If you would like to volunteer <strong>for</strong> one of<br />

these positions, know of someone willing<br />

to serve, or if you’d like additional<br />

in<strong>for</strong>mation about the duties of each position,<br />

please contact Melanie Quinlan or<br />

any member of the Executive Committee.<br />

Don’t pass up this opportunity to<br />

give back to the division and enhance<br />

your career. �<br />

Chair, <strong>DACC</strong> Nominating Committee<br />

Melanie Quinlan


Images from the <strong>2010</strong> <strong>DACC</strong> Spring Meeting: “Autoimmune Diseases and Inflammatory States:<br />

Emerging Research in the Pathogenesis, Detection, and Therapeutic Options ”<br />

Past-Chair Past Chair and Moderator<br />

Rosemary Nicklaus<br />

Rosemary Nicklaus, Thomas Misko, Jon Klover, Calvert Louden, Patricia Giclas,<br />

Barbara Litzenberger, Mike Bieraugel, (not pictured Chris Stevenson, Diagen Xu)<br />

Speaker:<br />

Diagen Xu<br />

9<br />

<strong>DACC</strong> Chair<br />

Mike Bieraugel<br />

Speakers:<br />

Thomas Misko and Jon Klover


A BIG THANKS Goes<br />

Out to Roche <strong>for</strong><br />

Hosting the <strong>DACC</strong><br />

Spring Meeting!!!<br />

<strong>2010</strong> ACVP/ASVCP<br />

CONCURRENT ANNUAL<br />

MEETINGS<br />

October 30– November 3, <strong>2010</strong><br />

Baltimore, MD<br />

http://www.acvp.org/meeting<br />

Awards Presentation<br />

Reception and Mixer<br />

Monday 7/26/<strong>2010</strong><br />

Tortilla Jo’s - Downtown Disney<br />

hosted by<br />

Siemens Healthcare Diagnostics<br />

10<br />

Volunteers are needed <strong>for</strong><br />

<strong>DACC</strong> committees. Join your<br />

colleagues in determining<br />

the future direction of<br />

the division<br />

The <strong>DACC</strong> Election is This Fall !<br />

For Chair-Elect, Treasurer and a Nominating Committee Member<br />

Please Run <strong>for</strong> Office<br />

The Election Process Depends on YOUR Vote !


<strong>DACC</strong> NEWS<br />

Editor Emeritus<br />

Robert E. Emmons<br />

3 Winston Drive<br />

Victor, NY 14564<br />

Phone: 585-924-5019<br />

reemmons@frontiernet.net<br />

Chair-Elect<br />

Barbara Litzenberger<br />

Huntingdon Life Sciences<br />

100 Mettlers Rd.<br />

East Millstone, NJ 08875<br />

Phone: 732-371-0852<br />

LitzenbB@Princeton.Huntingdon.com<br />

Nominating (Year as Chair)<br />

Melanie Quinlan (<strong>2010</strong>)<br />

Roseann Riley (2011)<br />

Karen Lynch (2012)<br />

Kay Criswell (2013)<br />

Mike Bieraugel (Exec Rep)<br />

Awards<br />

Jon Kimball (Chair)<br />

Jiro Kaneko<br />

Bob Emmons<br />

Doug Neptun<br />

<strong>DACC</strong> NEWS<br />

Division of Animal <strong>Clinical</strong> Chemistry<br />

<strong>DACC</strong> NEWS<br />

Editor<br />

Doug Neptun<br />

Antech Diagnostics GLP<br />

507 Airport Blvd, Suite 113<br />

Morrisville, NC 27560<br />

Phone: 919-277-0822<br />

doug.neptun@antechmail.com<br />

<strong>DACC</strong> <strong>2010</strong> Executive Committee<br />

Treasurer<br />

Joseph Sansone<br />

Allergan, Inc.<br />

2525 Dupont Drive, RD2-2C<br />

Irvine, CA 92612<br />

Phone: 714-246-4044<br />

sansone_joseph@allergan.com<br />

Chair<br />

Mike Bieraugel<br />

Allergan, Inc.<br />

2525 Dupont Drive, RD2-2C<br />

Irvine, CA 92612<br />

Phone: 714-246-6051<br />

bieraugel_michael@allergan.com<br />

Membership<br />

Joseph Sansone (Chair)<br />

Rosemary Nicklaus<br />

Ana Maria Roncal-<br />

Lahman<br />

Gail Walter<br />

Spring */<br />

Fall Meeting**<br />

Mike Bieraugel<br />

**Barbara Litzenberger<br />

*Rosemary Nicklaus<br />

Doug Thudium<br />

Kay Criswell<br />

* Principal Organizer<br />

11<br />

<strong>DACC</strong> NEWS<br />

Associate Editor<br />

Mike Bieraugel<br />

Allergan, Inc.<br />

2525 Dupont Drive, RD2-2C<br />

Irvine, CA 92612<br />

Phone: 714-246-6051<br />

bieraugel_michael@allergan.com<br />

Secretary<br />

Renee Pearson<br />

Pearson Consulting, LLC<br />

43332 Sugarbush Court<br />

Leesburg, VA 20176<br />

Phone: 703-663-0768<br />

dr.renee@verizon.com<br />

<strong>DACC</strong> <strong>2010</strong> Committees<br />

Scientific Program &<br />

Long Range Planning<br />

Mike Bieraugel (Chair)<br />

Rosemary Nicklaus<br />

Doug Thudium<br />

Kay Criswell<br />

Annual Meeting<br />

Rosemary Nicklaus (<strong>2010</strong>)<br />

Mike Bieraugel (2011)<br />

Doug Thudium<br />

Kay Criswell<br />

<strong>DACC</strong> NEWS<br />

Associate Editor<br />

Jon P. Kimball<br />

1732 Old Lystra Road<br />

Chapel Hill, NC 27517<br />

Phone: 919-967-4016<br />

jonkimball@msn.com<br />

Past-Chair<br />

Rosemary Nicklaus<br />

Roche<br />

340 Kingsland Street<br />

Nutley, NJ 07110-1150<br />

Phone: 973-235-3654<br />

rosemary.nicklaus@roche.com<br />

Fund Raising<br />

Jon Kimball<br />

Doug Neptun<br />

Chris Perigard<br />

Joe Sansone (Exec Rep)<br />

Regulatory Affairs &<br />

Intersociety Liaison<br />

Jon Kimball:<br />

ISACB<br />

Gail Walter:<br />

ASVCP/SOT/STP

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